MCID: BRN144
MIFTS: 21

Bronchiectasis 2

Categories: Genetic diseases, Respiratory diseases

Aliases & Classifications for Bronchiectasis 2

MalaCards integrated aliases for Bronchiectasis 2:

Name: Bronchiectasis 2 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080527

Summaries for Bronchiectasis 2

Disease Ontology : 12 A bronchiectasis that has material basis in mutation in the gene encoding the alpha subunit of the epithelial sodium channel.

MalaCards based summary : Bronchiectasis 2 is related to bronchiectasis and blood protein disease. An important gene associated with Bronchiectasis 2 is B2M (Beta-2-Microglobulin), and among its related pathways/superpathways are Human cytomegalovirus infection and Allograft rejection. The drugs Serine Proteinase Inhibitors and Alpha 1-Antitrypsin have been mentioned in the context of this disorder. Affiliated tissues include lung and heart.

Related Diseases for Bronchiectasis 2

Graphical network of the top 20 diseases related to Bronchiectasis 2:



Diseases related to Bronchiectasis 2

Symptoms & Phenotypes for Bronchiectasis 2

Drugs & Therapeutics for Bronchiectasis 2

Drugs for Bronchiectasis 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Serine Proteinase Inhibitors
2 Alpha 1-Antitrypsin
3
protease inhibitors
4 Pharmaceutical Solutions
5 HIV Protease Inhibitors
6 Trypsin Inhibitors
7 Protein C Inhibitor
8
Serine Investigational, Nutraceutical 56-45-1 5951

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Exhaled Breath Analysis in Patients With COPD and Bronchiectasis Unknown status NCT01410422
2 Exercise Capacity in Patients With Cystic Fibrosis vs. Non-cystic Fibrosis Bronchiectasis Unknown status NCT03147651
3 Patterns of Physical Activity in a Healthy Population Aged Over 40 Years Old Completed NCT01758003
4 Effects of Inhaled Alpha-1-anti-trypsin on Proteolytic Activity in BAL of Bronchiectasis Patients With Chronic Bronchial Expectoration Completed NCT03383939 Group A;Group B
5 Predictors of Physical Activity Performance and Dynamic Hyperinflation in Patients With Bronchiectasis Completed NCT04234789
6 The BRIDGE Study - Bronchiectasis Research Involving Databases, Genomics and Endotyping. An EMBARC2 Study Recruiting NCT03791086
7 Huai'an First People 's Hospital,Nanjing Medical University Recruiting NCT03021681

Search NIH Clinical Center for Bronchiectasis 2

Genetic Tests for Bronchiectasis 2

Anatomical Context for Bronchiectasis 2

MalaCards organs/tissues related to Bronchiectasis 2:

40
Lung, Heart

Publications for Bronchiectasis 2

Articles related to Bronchiectasis 2:

(show all 24)
# Title Authors PMID Year
1
KMBARC registry: protocol for a multicentre observational cohort study on non-cystic fibrosis bronchiectasis in Korea. 61
31959610 2020
2
Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale. 61
32545998 2020
3
An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13. 61
31073086 2019
4
Single- and Double-Lung Transplantation: Results of an Initial Experience of 39 Cases in Ceará (Northeast Brazil). 61
29661444 2018
5
Long-term outcome of hematopoietic stem cell transplantation for IL2RG/JAK3 SCID: a cohort report. 61
28209722 2017
6
The Incidence and Short-term Outcomes of Acute Respiratory Illness with Cough in Children from a Socioeconomically Disadvantaged Urban Community in Australia: A Community-Based Prospective Cohort Study. 61
29164080 2017
7
Imaging of Cystic Fibrosis and Pediatric Bronchiectasis. 61
26901001 2016
8
The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects. 61
25492164 2014
9
Frequency of acute worsening events in fibrotic pulmonary sarcoidosis patients. 61
24211131 2013
10
Major pulmonary resections by exclusive VTS. a first in Tunisia. 61
24227504 2013
11
Efficacy of extracorporeal membrane oxygenation as a bridge to lung transplantation. 61
23332185 2013
12
[Complete video-assisted thoracoscopic anatomic segmentectomy for pulmonary diseases: the early experiences]. 61
23157959 2012
13
Bronchiectasis and hoarseness of voice in takayasu arteritis: a rare presentation. 61
22905814 2012
14
British Thoracic Society guideline for non-CF bronchiectasis. 61
20627931 2010
15
Effects of a pulmonary rehabilitation programme on physiologic and psychosocial outcomes in patients with chronic respiratory disorders. 61
11242618 2001
16
Bronchopulmonary hygiene physical therapy in bronchiectasis and chronic obstructive pulmonary disease: a systematic review. 61
10739489 2000
17
Home mechanical ventilation: investigation of 34 cases in Taiwan. 61
8935374 1996
18
Bronchial artery embolization to control haemoptysis. 61
7993246 1994
19
Long-term results of combined heart-lung transplantation: the Stanford experience. 61
7865527 1994
20
A bronchofibroscopic analysis of the bronchial mucosa using a dye-scattering method for the detection of bronchial lesions. 61
8420419 1993
21
Isolation and structural characterization of novel neutral oligosaccharide-alditols from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis. 2. Structure of twelve hepta-to-nonasaccharides, six of which possess the GlcNAc beta(1----3)[Gal beta(1----4)GlcNAc beta(1----6)]Gal beta(1----3)GalNAc-ol common structural element. 61
2040278 1991
22
Surgical resection for complications of pulmonary tuberculosis. 61
2764608 1989
23
[Effects of hypopressure on blood gases and spirograms of patients suffering from chronic respiratory failure]. 61
2515332 1989
24
Complexities of establishing an early diagnosis of allergic bronchopulmonary aspergillosis in children. 61
2647584 1989

Variations for Bronchiectasis 2

Expression for Bronchiectasis 2

Search GEO for disease gene expression data for Bronchiectasis 2.

Pathways for Bronchiectasis 2

Pathways related to Bronchiectasis 2 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.75 VEGFA B2M
2
Show member pathways
11.37 VEGFA B2M

GO Terms for Bronchiectasis 2

Cellular components related to Bronchiectasis 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.62 VEGFA B2M

Molecular functions related to Bronchiectasis 2 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 8.62 VEGFA B2M

Sources for Bronchiectasis 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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