MCID: BRN145
MIFTS: 24

Bronchiectasis 3

Categories: Genetic diseases, Respiratory diseases

Aliases & Classifications for Bronchiectasis 3

MalaCards integrated aliases for Bronchiectasis 3:

Name: Bronchiectasis 3 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080528

Summaries for Bronchiectasis 3

Disease Ontology : 12 A bronchiectasis that has material basis in mutation in the gene encoding the gamma subunit of the epithelial sodium channel.

MalaCards based summary : Bronchiectasis 3 is related to premenstrual tension and outlet dysfunction constipation. An important gene associated with Bronchiectasis 3 is SLCO2B1 (Solute Carrier Organic Anion Transporter Family Member 2B1), and among its related pathways/superpathways are Phenytoin Pathway, Pharmacokinetics and Codeine and Morphine Metabolism.

Related Diseases for Bronchiectasis 3

Diseases in the Bronchiectasis family:

Bronchiectasis 1 Bronchiectasis 2
Bronchiectasis 3

Diseases related to Bronchiectasis 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 premenstrual tension 10.1 GNRH1 CYP3A5
2 outlet dysfunction constipation 10.0 LCT CYP3A4
3 steroid inherited metabolic disorder 10.0 GNRH1 CYP17A1
4 mandibular cancer 10.0 KLK3 GNRH1
5 leydig cell tumor 10.0 GNRH1 CYP17A1
6 hepatocellular adenoma 10.0 SLCO1B3 CYP3A4
7 pelvic varices 10.0 KLK3 GNRH1
8 clopidogrel resistance 10.0 CYP3A5 CYP3A4
9 lipoid congenital adrenal hyperplasia 10.0 GNRH1 CYP17A1
10 transsexualism 9.9 CYP17A1 AR
11 gender identity disorder 9.9 CYP17A1 AR
12 prostate adenoid cystic carcinoma 9.9 KLK3 AR
13 prostate leiomyoma 9.9 KLK3 AR
14 prostate calculus 9.9 KLK3 AR
15 nodular prostate 9.9 KLK3 AR
16 prostatic acinar adenocarcinoma 9.9 KLK3 AR
17 prostatic hyperplasia, benign 9.9 KLK3 AR
18 prostate neuroendocrine neoplasm 9.8 KLK3 AR
19 prostate transitional cell carcinoma 9.8 KLK3 AR
20 gilbert syndrome 9.8 SLCO1B3 CYP3A5 CYP3A4
21 male reproductive organ benign neoplasm 9.8 KLK3 AR
22 prostatic adenoma 9.8 KLK3 AR
23 withdrawal disorder 9.8 KLK3 AR
24 androgenic alopecia 9.8 KLK3 AR
25 intrahepatic cholestasis of pregnancy 9.8 SLCO1B3 CYP3A4 CYP17A1
26 prostatic hypertrophy 9.8 KLK3 AR
27 lymph node carcinoma 9.8 KLK3 AR
28 teeth hard tissue disease 9.8 GNRH1 AR
29 proctitis 9.8 KLK3 CYP3A5 CYP3A4
30 female breast cancer 9.7 KLK3 AR
31 impotence 9.7 KLK3 GNRH1 CYP3A4
32 varicocele 9.7 GNRH1 AR
33 bilirubin metabolic disorder 9.7 SLCO2B1 SLCO1B3 CYP3A5 CYP3A4
34 testicular disease 9.7 GNRH1 AR
35 penis agenesis 9.6 GNRH1 CYP17A1 AR
36 oligospermia 9.6 GNRH1 AR
37 sebaceous gland disease 9.6 GNRH1 CYP17A1 AR
38 disorder of sexual development 9.6 GNRH1 CYP17A1 AR
39 aromatase excess syndrome 9.6 GNRH1 CYP17A1 AR
40 hyperandrogenism 9.6 GNRH1 CYP17A1 AR
41 androgen insensitivity syndrome 9.6 CYP17A1 AR
42 46,xy sex reversal 9.6 GNRH1 CYP17A1 AR
43 testicular germ cell cancer 9.6 CYP3A5 CYP3A4 AR
44 polycystic ovary syndrome 9.6 GNRH1 CYP17A1 AR
45 cryptorchidism, unilateral or bilateral 9.6 GNRH1 CYP17A1 AR
46 ovarian disease 9.6 GNRH1 CYP17A1 AR
47 amelogenesis imperfecta 9.5 GNRH1 CYP17A1 AR
48 premature menopause 9.5 GNRH1 CYP17A1 AR
49 testicular cancer 9.5 GNRH1 CYP3A4 AR
50 male infertility 9.5 GNRH1 CYP17A1 AR

Graphical network of the top 20 diseases related to Bronchiectasis 3:



Diseases related to Bronchiectasis 3

Symptoms & Phenotypes for Bronchiectasis 3

Drugs & Therapeutics for Bronchiectasis 3

Search Clinical Trials , NIH Clinical Center for Bronchiectasis 3

Genetic Tests for Bronchiectasis 3

Anatomical Context for Bronchiectasis 3

Publications for Bronchiectasis 3

Articles related to Bronchiectasis 3:

(show all 19)
# Title Authors PMID Year
1
Pulmonary manifestations of immune dysregulation in CTLA-4 haploinsufficiency and LRBA deficiency. 61
33710794 2021
2
Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality: Age Gene/Environment Susceptibility-Reykjavik Study. 61
33748349 2021
3
Long-term outcome of Tunisian children with primary ciliary dyskinesia confirmed by transmission electron microscopy. 61
28479887 2016
4
Imaging of Cystic Fibrosis and Pediatric Bronchiectasis. 61
26901001 2016
5
Experiences and challenges of thorcoscopic lung surgery in the pediatric age group. 61
26475091 2015
6
[Etiology, clinical features, and diagnosis and treatment of recurrent hemoptysis in children]. 61
24661522 2014
7
Major respiratory adverse events after laparascopic gastric banding surgery for morbid obesity. 61
22673900 2012
8
Heterogeneity of bronchitis in airway diseases in tertiary care clinical practice. 61
21766077 2011
9
Tiotropium ameliorates symptoms in patients with chronic airway mucus hypersecretion which is resistant to macrolide therapy. 61
18379141 2008
10
The natural history of asthma in adults: the problem of irreversibility. 61
10199998 1999
11
["Primary" diffuse interstitial fibrosis in coal miners: a new entity? Study Group on Interstitial Pathology of the Society of Thoracic Pathology of the North]. 61
9411611 1997
12
[Outcomes of noninvasive positive-pressure ventilation in patients with acute hypercapnia complicating chronic respiratory failure]. 61
9396253 1997
13
[The selection of patients who are candidates for lung transplantation]. 61
8677046 1996
14
alpha 1-Antitrypsin deficiency in Indian patients with chronic obstructive airways and other pulmonary diseases. 61
7923455 1994
15
[Therapeutic efficacy of ceftibuten in chronic respiratory tract infections]. 61
2391748 1990
16
[Respiratory infections caused by Branhamella catarrhalis in 5 different hospitals]. 61
2120497 1990
17
[Clinical and ultrastructural study on primary ciliary dyskinesia]. 61
2355699 1990
18
Efficacy and pharmacokinetics of Timentin in paediatric infections. 61
3636339 1986
19
[Clinical experiences of lividomycin on respiratory tract infections (author's transl)]. 61
1041282 1975

Variations for Bronchiectasis 3

Expression for Bronchiectasis 3

Search GEO for disease gene expression data for Bronchiectasis 3.

Pathways for Bronchiectasis 3

Pathways related to Bronchiectasis 3 according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.42 CYP3A5 CYP3A4
2
Show member pathways
11.4 SLCO1B3 CYP3A4
3
Show member pathways
11.37 CYP3A5 CYP3A4
4
Show member pathways
11.37 CYP3A5 CYP3A4 CYP17A1
5 11.35 KLK3 AR
6 11.29 CYP3A5 CYP3A4
7 11.27 KLK3 AR
8
Show member pathways
11.23 KLK3 AR
9
Show member pathways
11.23 CYP3A5 CYP3A4 CYP17A1
10 11.21 CYP3A4 AR
11
Show member pathways
11.15 SLCO1B3 CYP3A5 CYP3A4
12
Show member pathways
11.14 CYP3A5 CYP3A4
13
Show member pathways
11.08 CYP3A5 CYP3A4
14 11.03 CYP3A5 CYP3A4
15
Show member pathways
10.98 SLCO2B1 SLCO1B3 CYP3A5 CYP3A4
16 10.91 SLCO1B3 CYP3A5 CYP3A4
17 10.87 CYP3A5 CYP3A4
18 10.77 SLCO2B1 CYP3A4
19 10.73 GNRH1 AR
20
Show member pathways
10.66 SLCO1B3 CYP3A5 CYP3A4
21 10.63 CYP3A5 CYP3A4
22 10.61 CYP3A5 CYP3A4
23 10.4 CYP3A5 CYP3A4

GO Terms for Bronchiectasis 3

Cellular components related to Bronchiectasis 3 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.8 CYP3A5 CYP3A4 CYP17A1

Biological processes related to Bronchiectasis 3 according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 steroid biosynthetic process GO:0006694 9.52 CYP3A4 CYP17A1
2 retinol metabolic process GO:0042572 9.51 CYP3A5 CYP3A4
3 bile acid and bile salt transport GO:0015721 9.49 SLCO2B1 SLCO1B3
4 estrogen metabolic process GO:0008210 9.48 CYP3A5 CYP3A4
5 retinoic acid metabolic process GO:0042573 9.46 CYP3A5 CYP3A4
6 organic anion transport GO:0015711 9.43 SLCO2B1 SLCO1B3
7 steroid metabolic process GO:0008202 9.43 CYP3A5 CYP3A4 CYP17A1
8 sodium-independent organic anion transport GO:0043252 9.4 SLCO2B1 SLCO1B3
9 oxidative demethylation GO:0070989 9.37 CYP3A5 CYP3A4
10 regulation of systemic arterial blood pressure GO:0003073 9.32 KLK3 AR
11 lipid hydroxylation GO:0002933 9.16 CYP3A5 CYP3A4
12 drug catabolic process GO:0042737 8.96 CYP3A5 CYP3A4
13 alkaloid catabolic process GO:0009822 8.62 CYP3A5 CYP3A4

Molecular functions related to Bronchiectasis 3 according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.65 CYP3A5 CYP3A4 CYP17A1
2 iron ion binding GO:0005506 9.61 CYP3A5 CYP3A4 CYP17A1
3 steroid hydroxylase activity GO:0008395 9.55 CYP3A5 CYP3A4
4 steroid binding GO:0005496 9.54 CYP3A4 AR
5 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.52 CYP3A5 CYP3A4
6 aromatase activity GO:0070330 9.51 CYP3A5 CYP3A4
7 sodium-independent organic anion transmembrane transporter activity GO:0015347 9.49 SLCO2B1 SLCO1B3
8 organic anion transmembrane transporter activity GO:0008514 9.46 SLCO2B1 SLCO1B3
9 monooxygenase activity GO:0004497 9.43 CYP3A5 CYP3A4 CYP17A1
10 bile acid transmembrane transporter activity GO:0015125 9.4 SLCO2B1 SLCO1B3
11 retinoic acid 4-hydroxylase activity GO:0008401 9.37 CYP3A5 CYP3A4
12 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.33 CYP3A5 CYP3A4 CYP17A1
13 estrogen 16-alpha-hydroxylase activity GO:0101020 9.32 CYP3A5 CYP3A4
14 testosterone 6-beta-hydroxylase activity GO:0050649 8.96 CYP3A5 CYP3A4
15 oxygen binding GO:0019825 8.8 CYP3A5 CYP3A4 CYP17A1

Sources for Bronchiectasis 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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