MCID: BRN002
MIFTS: 62

Bronchiolitis

Categories: Respiratory diseases, Skin diseases

Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 55 6 3 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 44 D001988
NCIt 50 C39658
SNOMED-CT 68 4120002
UMLS 73 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and extrinsic allergic alveolitis, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Epinephrine and Bromhexine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and skin, and related phenotypes are Reduced mammosphere formation and hematopoietic system

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 76 Bronchiolitis is blockage of the small airway in the lungs due to a viral infection. It usually only... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 529)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 34.1 CXCL8 IFNG IL10 IL17A IL6 TNF
2 extrinsic allergic alveolitis 32.2 CCL5 CXCL8 IL10 IL6
3 bronchitis 32.0 CCL11 CXCL8 IL5 RNASE3 TNF
4 respiratory syncytial virus infectious disease 31.3 CCL3 CCL5 IL13 IL5
5 hematopoietic stem cell transplantation 30.8 IFNG IL10 IL6 TNF
6 chronic graft versus host disease 30.7 IFNG IL10 TNF
7 graft-versus-host disease 30.7 IFNG IL10 IL6 TNF
8 bronchial disease 30.6 CCL11 CCL5 CXCL8 IL10 IL13 IL17A
9 arthritis 30.5 CXCL8 IFNG IL10 IL17A IL6 TNF
10 acute respiratory distress syndrome 30.4 CXCL8 IL6 TNF
11 interstitial lung disease 30.3 CCL5 CXCL8 IFNG IL10 IL4 IL6
12 pneumonia 30.1 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
13 ulcerative colitis 30.1 CXCL8 IFNG IL10 IL17A IL6 TLR4
14 pertussis 30.0 IL10 IL6 TLR4 TNF
15 cryptococcosis 30.0 IFNG IL4 TLR9
16 castleman disease 30.0 IL10 IL5 IL6
17 chronic eosinophilic pneumonia 30.0 CCL11 CCL5 IL5 RNASE3
18 cytomegalovirus infection 29.9 CCL3 CCL5 CXCL8 IL6 TNF
19 viral pneumonia 29.9 IL17A IL6 TLR9
20 ascaridiasis 29.9 IL10 IL13
21 pulmonary edema 29.9 CXCL8 IL10 TNF
22 pulmonary sarcoidosis 29.9 CCL5 IFNG TNF
23 hyperlucent lung 29.9 IFNG IL10 IL4
24 synovitis 29.8 CXCL8 IL6 TNF
25 spondyloarthropathy 1 29.8 IL17A TLR4 TNF
26 eosinophilic pneumonia 29.8 CCL11 CCL5 IL13 IL5 RNASE3
27 spondylitis 29.8 IL17A IL6 TNF
28 colitis 29.8 CXCL8 IFNG IL10 IL17A IL4 IL6
29 cellulitis 29.8 IL5 RNASE3 TNF
30 arteries, anomalies of 29.7 IL6 TLR9 TNF
31 myasthenia gravis 29.7 IFNG IL10 IL4 TNF
32 adult respiratory distress syndrome 29.7 CXCL8 IL10 IL6 TNF
33 connective tissue disease 29.7 IFNG IL10 IL6 TLR9 TNF
34 plasmodium vivax malaria 29.7 IFNG IL10 IL6 TNF
35 acute graft versus host disease 29.7 IFNG IL10 IL4 TNF
36 rheumatoid arthritis 29.7 CCL3 CCL5 CXCL8 IFNG IL10 IL17A
37 cystitis 29.7 CXCL8 IL6 TLR4 TNF
38 chlamydia 29.6 CXCL8 IFNG IL10 IL4 IL6 TLR4
39 psoriatic arthritis 29.6 IL13 IL17A IL6 TNF
40 systemic lupus erythematosus 29.5 CCL5 CXCL8 IFNG IL10 IL17A IL4
41 viral infectious disease 29.5 CCL3 CCL5 CXCL8 IFNG IL10 IL4
42 ascaris lumbricoides infection 29.5 CXCL8 IFNG IL13 IL5
43 lung disease 29.4 CCL3 CCL5 CXCL8 IL10 IL13 IL17A
44 pulmonary disease, chronic obstructive 29.4 CCL11 CCL5 CXCL8 IL13 IL17A IL6
45 myeloma, multiple 29.4 CCL3 CXCL8 IL6 TLR9 TNF
46 aspergillosis 29.3 IFNG IL10 IL4 IL5 TLR4 TLR9
47 acquired immunodeficiency syndrome 29.3 CCL3 IFNG IL10 IL6 TNF
48 common variable immunodeficiency 29.3 IFNG IL10 IL4 IL5 IL6 TLR9
49 human immunodeficiency virus infectious disease 29.3 CCL3 CCL5 IFNG IL10 IL6 TLR9
50 idiopathic interstitial pneumonia 29.3 CXCL8 IFNG IL13 IL4 MUC5B TLR9

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

Symptoms:

12
  • fever
  • cough
  • wheezing
  • shortness of breath
  • nasal flaring in infants
  • bluish skin due to lack of oxygen

GenomeRNAi Phenotypes related to Bronchiolitis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CCL3 CXCL8 IL17A IL4R IL5 TLR10

MGI Mouse Phenotypes related to Bronchiolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CCL11 CCL5 IFNG IL10 IL13 IL17A
2 digestive/alimentary MP:0005381 10.14 IFNG IL10 IL13 IL17A IL4 IL4R
3 homeostasis/metabolism MP:0005376 10.1 IFNG IL10 IL13 IL17A IL4 IL4R
4 immune system MP:0005387 10.1 CCL11 CCL5 IFNG IL10 IL13 IL17A
5 integument MP:0010771 9.76 IFNG IL10 IL13 IL4 IL4R IL6
6 liver/biliary system MP:0005370 9.56 IFNG IL10 IL4 IL4R IL5 IL6
7 respiratory system MP:0005388 9.4 CCL11 IFNG IL10 IL13 IL17A IL4

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 254)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
2
Bromhexine Approved Phase 4 3572-43-8
3
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
6
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83905-01-5 55185 447043
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
8
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
11
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
12
Montelukast Approved Phase 4,Phase 3,Phase 2,Not Applicable 158966-92-8 5281040
13
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-75-2 4033
14
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
15
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
16
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
17
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
18
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
19
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 104987-11-3 445643 439492
20
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2 159351-69-6 6442177
21
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 53123-88-9 46835353 6436030 5284616
22
Fluticasone Approved, Experimental Phase 4,Phase 2,Not Applicable 90566-53-3 62924
23
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
24
Macitentan Approved Phase 4 441798-33-0
25
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-14-6 5280793
26
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 5280795 6221
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
28
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
29 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
30 Calamus Phase 4,Phase 3,Not Applicable
31 Sympathomimetics Phase 4,Phase 3,Phase 2,Not Applicable
32 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
33 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Mydriatics Phase 4,Phase 3,Phase 2,Not Applicable
37 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
39 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable
46 Micronutrients Phase 4,Phase 3,Phase 2,Not Applicable
47 Calciferol Phase 4,Phase 3,Phase 2,Not Applicable
48 Ergocalciferols Phase 4,Phase 3,Phase 2,Not Applicable
49 Vitamin D2 Phase 4,Phase 3,Phase 2,Not Applicable
50 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 349)
# Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in Bronchiolitis Unknown status NCT01216553 Phase 4
2 High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Unknown status NCT03015051 Phase 4 Oxygen
3 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
4 Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection Unknown status NCT02054182 Phase 4 Vitamin D
5 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
6 Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
7 7% Hypertonic Saline for Acute Bronchiolitis Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
8 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
9 Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
10 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
11 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
12 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Bronchiolitis. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
13 Hypertonic Saline for Acute Bronchiolitis Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
14 Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
15 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
16 Vitamin D in Bronchiolitis Obliterans Syndrome Completed NCT01212406 Phase 4 Vitamin D
17 Impact of Oximetry on Hospitalization in Acute Bronchiolitis Completed NCT00673946 Phase 4
18 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4 Montelukast
19 Use of Erythromycin in Mustard-Induced Bronchiolitis Completed NCT00367419 Phase 4 Erythromycin
20 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis Completed NCT00119002 Phase 4 dexamethasone;Placebo
21 Azithromycin in Bronchiolitis Obliterans Syndrome Completed NCT01009619 Phase 4 Azithromycin;Placebo
22 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
23 Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
24 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
25 Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
26 Comparison of Sirolimus and Azathioprine in Lung Transplantation Completed NCT00321906 Phase 4 azathioprine;sirolimus
27 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
28 "Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial" Inpatient Hospital Use: A Randomized Controlled Trial" Not yet recruiting NCT03364218 Phase 4 N acetyl cysteine nebulized
29 Macitentan in the Treatment of Organ Rejection After Lung Transplantation Not yet recruiting NCT02893176 Phase 4 macitentan;placebo (for macitentan)
30 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
31 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
32 Treatment Of Bronchiolitis With Heated Humidified High Flow Nasal Cannula - Prospective And Retrospective Research Unknown status NCT02366715 Phase 3
33 Comparison Between 2l vs 3l in HFNC During the Initial Management of Severe Bronchiolitis in Infants Unknown status NCT02824744 Phase 3
34 The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis Unknown status NCT02531984 Phase 3 Azithromycin
35 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
36 Heliox-Driven Racemic Epinephrine Nebulization in Treatment of Moderate to Severe Bronchiolitis in Pediatric ED Patients Completed NCT00116584 Phase 3 heliox
37 The SABRE Trial of Hypertonic Saline in Acute Bronchiolitis Completed NCT01469845 Phase 3
38 Nasal Irrigation in Infants With Bronchiolitis. Completed NCT02162745 Phase 3 Isotonic solution (NaCl 0.9%);Hypertonic solution (NaCl 3%)
39 An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272) Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo
40 "Palivizumab Therapy for RSV-bronchiolitis" Completed NCT02442427 Phase 3 Palivizumab
41 Nebulized Hypertonic Saline for Bronchiolitis Completed NCT00619918 Phase 2, Phase 3 Nebulized 3% saline;Placebo
42 Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
43 High Flow Therapy vs Hypertonic Saline in Bronchiolitis Completed NCT01873144 Phase 3 Epinephrine 1/1000;HSS 3%;NS (0.9%)
44 Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
45 Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations Completed NCT01812525 Phase 3 NaCl 3%
46 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
47 Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation Completed NCT01429844 Phase 3 Tacrolimus;Cyclosporine
48 Effect of Heliox on RSV Bronchiolitis Completed NCT03171142 Phase 3 Heliox;Air
49 Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis Completed NCT01777347 Phase 3 3% Saline;0.9% Normal Saline
50 The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants. Completed NCT00151905 Phase 2, Phase 3 3 % hypertonic saline

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

41
Lung, Bone, Skin, Bone Marrow, Heart, Testes, T Cells

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 2587)
# Title Authors Year
1
Bronchiolitis Obliterans and Pulmonary Fibrosis After Sulfur Mustard Inhalation in Rats. ( 29314868 )
2018
2
Bronchiolitis obliterans syndrome susceptibility and the pulmonary microbiome. ( 29929823 )
2018
3
Network Meta-Analysis Comparing the Efficacy of Therapeutic Treatments for Bronchiolitis in Children. ( 29388676 )
2018
4
RSV-hRV co-infection is a risk factor for recurrent bronchial obstruction and early sensitization 3 years after bronchiolitis. ( 29380391 )
2018
5
Bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for lung cancer: A case report. ( 29395853 )
2018
6
Bronchiolitis obliterans organising pneumonia as an initial manifestation in a patient with systemic lupus erythematosus: a rare presentation. ( 29804073 )
2018
7
High-Resolution CT Findings of Obstructive and Restrictive Phenotypes of Chronic Lung Allograft Dysfunction: More Than Just Bronchiolitis Obliterans Syndrome. ( 29792746 )
2018
8
No Cause for Alarm: Decreasing Inappropriate Pulse Oximetry Use in Bronchiolitis. ( 29382688 )
2018
9
NKG2D gene variation and susceptibility to viral bronchiolitis in childhood. ( 29967528 )
2018
10
The emerging spectrum of exposure-related bronchiolitis. ( 29394172 )
2018
11
Machine Learning Algorithms Utilizing Quantitative CT Features May Predict Eventual Onset of Bronchiolitis Obliterans Syndrome After Lung Transplantation. ( 29472146 )
2018
12
High-Flow Oxygen Therapy in Infants with Bronchiolitis. ( 29926713 )
2018
13
IL-17A gene polymorphism rs2275913 is associated with the development of asthma after bronchiolitis in infancy. ( 28647382 )
2018
14
Bronchiolitis obliterans murine model induced by nitric acid aerosol inhalation: An economical and reproducible model. ( 29683731 )
2018
15
Montelukast for bronchiolitis obliterans syndrome after lung transplantation: A randomized controlled trial. ( 29624575 )
2018
16
Efficacy of high-dose steroids for bronchiolitis obliterans syndrome post pediatric hematopoietic stem cell transplantation. ( 29417689 )
2018
17
Comparing of two different epidemic seasons of bronchiolitis. ( 29338779 )
2018
18
Outcomes of Follow-up Visits After Bronchiolitis Hospitalizations. ( 29379947 )
2018
19
High-Flow Oxygen Therapy in Infants with Bronchiolitis. ( 29927185 )
2018
20
A case series on common cold to severe bronchiolitis and pneumonia in children following human metapneumovirus infection in Sri Lanka. ( 29444701 )
2018
21
Radiological Improvement of Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation in a Patient Treated with Ruxolitinib. ( 29803525 )
2018
22
Obliterative bronchiolitis associated with rheumatoid arthritis: analysis of a single-center case series. ( 29929518 )
2018
23
Helmet Versus Nasal-Prong CPAP in Infants With Acute Bronchiolitis. ( 29382794 )
2018
24
High-Flow Oxygen Therapy in Infants with Bronchiolitis. ( 29927181 )
2018
25
Impact of lung function on bronchiolitis obliterans syndrome and outcome after allogeneic hematopoietic cell transplantation with reduced intensity conditioning. ( 29964193 )
2018
26
Post-infectious bronchiolitis obliterans in children: is general quality of life the right measure? ( 29438684 )
2018
27
Trends in hospitalization for acute bronchiolitis in Portugal: 2000-2015. ( 29898876 )
2018
28
Using a high-flow nasal cannula provides superior results to OxyMask delivery in moderate to severe bronchiolitis: a randomized controlled study. ( 29915869 )
2018
29
Transaminase levels reflect disease severity in children ventilated for respiratory syncytial virus (RSV) bronchiolitis. ( 29379110 )
2018
30
Effectiveness of Respiratory Syncytial Virus Immunoprophylaxis on Bronchiolitis Hospitalizations among High-risk Infants. ( 29351636 )
2018
31
Home spirometry in bronchiolitis obliterans post allogeneic haematopoietic cell transplant. ( 29794130 )
2018
32
Bronchodilators in bronchiolitis: Yes or no? ( 29333805 )
2018
33
Postinfectious bronchiolitis obliterans ( 29775038 )
2018
34
Mycobacterium abscessus and massiliense lung infection during macrolide treatment for bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. ( 28988958 )
2018
35
Evaluating for Bronchiolitis Obliterans with Low Attenuation CT 3D Reconstructions. ( 29406777 )
2018
36
Prenatal and postnatal tobacco smoke exposure and risk of severe bronchiolitis during infancy. ( 29957275 )
2018
37
High-Flow Oxygen Therapy in Infants with Bronchiolitis. ( 29927187 )
2018
38
The management of children with bronchiolitis in the Australasian hospital setting: development of a clinical practice guideline. ( 29433429 )
2018
39
High circulating CD4<sup>+</sup>CD25<sup>hi</sup>FOXP3<sup>+</sup> T-cell sub-population early after lung transplantation is associated with development of bronchiolitis obliterans syndrome. ( 29571601 )
2018
40
Mesalazine-induced Bronchiolitis Obliterans with Organizing Pneumonia in a young patient with Ulcerative Colitis. ( 29931114 )
2018
41
Surfactant Dysfunction in ARDS and Bronchiolitis is Repaired with Cyclodextrins. ( 29635617 )
2018
42
Bronchiolitis obliterans syndrome is associated with increased p-glycoprotein expression and loss of glucocorticoid receptor from steroid-resistant proinflammatory CD8<sup>+</sup>T cells. ( 29352737 )
2018
43
Risk factors for bronchiolitis severity: a retrospective review of patients admitted to the University Hospital from Central region of Slovenia. ( 29944781 )
2018
44
Bronchiolitis obliterans in a transplant-waitlisted patient with hepatorenal polycystic disease. ( 29907421 )
2018
45
Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome After Lung Transplantation. ( 29557913 )
2018
46
Obliterating Bronchiolitis: Result of Iron Pill Aspiration. ( 29974026 )
2018
47
Extracorporeal Photopheresis Improves Survival in Hematopoietic Cell Transplant Patients with Bronchiolitis Obliterans Syndrome without Significantly Impacting Measured Pulmonary Functions. ( 29679771 )
2018
48
Implementing evidence-based practices in the care of infants with bronchiolitis in Australasian acute care settings: study protocol for a cluster randomised controlled study. ( 29980177 )
2018
49
New mouse model of pulmonary hypertension induced by respiratory syncytial virus bronchiolitis. ( 29906223 )
2018
50
Change in viral bronchiolitis management in hospitals in the UK after the publication of NICE guideline. ( 29909244 )
2018

Variations for Bronchiolitis

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
2
Show member pathways
13.97 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
3
Show member pathways
13.81 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4
Show member pathways
13.69 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
5
Show member pathways
13.52 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE
6
Show member pathways
13.52 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
7
Show member pathways
13.45 CCL11 CCL3 CCL5 CXCL8 IL10 IL13
8
Show member pathways
13.28 IFNG IL4 IL4R TLR10 TLR4 TLR9
9
Show member pathways
13.18 CCL3 CCL5 CXCL8 IFNG IL10 IL6
10
Show member pathways
13.12 CCL3 CCL5 CXCL8 IL6 TLR4 TNF
11
Show member pathways
13.04 CCL11 CXCL8 IFNG IL10 IL13 IL17A
12
Show member pathways
12.99 CCL5 CXCL8 IFNG IL13 IL4 IL6
13 12.97 CXCL8 IFNG IL13 IL4 IL4R IL5
14
Show member pathways
12.87 CCL5 CXCL8 IFNG IL6 TLR4 TNF
15
Show member pathways
12.81 IFNG IL10 IL13 IL17A IL4 IL4R
16
Show member pathways
12.77 IL6 TLR10 TLR4 TLR9 TNF
17
Show member pathways
12.76 IFNG IGHE IL10 IL4 IL4R TNF
18 12.75 CCL5 IFNG IL10 IL17A IL4 TLR9
19
Show member pathways
12.67 IFNG IL10 IL17A IL6 TNF
20
Show member pathways
12.67 IGHE IL13 IL4 IL5 TNF
21
Show member pathways
12.62 IFNG IL10 IL17A IL4 IL5 IL6
22
Show member pathways
12.58 IFNG IL10 IL13 IL4 IL4R IL5
23
Show member pathways
12.47 CXCL8 IFNG IL10 IL13 IL17A IL4
24
Show member pathways
12.46 CCL5 IFNG IL4 IL6 TNF
25
Show member pathways
12.46 CCL11 CXCL8 IFNG IL13 IL17A IL4
26
Show member pathways
12.45 CXCL8 IL6 TLR10 TLR4 TLR9 TNF
27
Show member pathways
12.44 CCL11 IGHE IL4 IL4R
28
Show member pathways
12.43 CXCL8 IFNG IL6 TLR4 TNF
29 12.42 IFNG IL10 IL6 TLR4 TLR9 TNF
30
Show member pathways
12.42 CCL11 CXCL8 IFNG IL4 IL6 TLR4
31
Show member pathways
12.39 IFNG IL10 IL4 TLR4 TNF
32 12.37 IFNG IL6 TLR10 TLR4 TLR9 TNF
33
Show member pathways
12.36 CCL11 CCL3 CCL5 CXCL8 TLR10 TLR4
34 12.32 CXCL8 IL10 IL13 IL6 TNF
35
Show member pathways
12.3 CXCL8 IL6 MUC5B TNF
36
Show member pathways
12.3 IFNG IL10 IL17A IL6 TLR10 TLR4
37
Show member pathways
12.29 IL10 IL6 TLR9 TNF
38
Show member pathways
12.24 IFNG IL13 IL4 IL6 TLR4 TNF
39 12.22 CXCL8 IFNG IL4 IL6 TLR4 TNF
40
Show member pathways
12.2 IL13 IL5 TLR10 TLR4 TLR9
41 12.2 IFNG IL10 IL4 IL5 IL6 TNF
42
Show member pathways
12.16 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
43 12.11 CXCL8 IFNG IL10 IL6 TLR4 TNF
44
Show member pathways
12.1 CCL11 CCL3 CCL5 CXCL8
45 12.08 IL4 IL4R IL5 IL6 TNF
46 12.07 CCL3 CCL5 CXCL8 IFNG IL17A IL6
47 12.06 CCL3 CXCL8 IFNG IL6
48 12.03 CCL3 CXCL8 IFNG IL6 TLR4
49 12.03 CXCL8 IFNG IL13 IL4 IL5 IL6
50 12.01 CCL11 CXCL8 IGHE IL10 IL13 IL17A

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.83 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
2 external side of plasma membrane GO:0009897 9.55 IGHE IL13 IL17A TLR4 TNF
3 extracellular region GO:0005576 9.55 CCL11 CCL3 CCL5 CXCL8 IFNG IGHE

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.99 CCL11 CCL3 CCL5 CXCL8
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 IL10 IL5 IL6 TNF
3 response to virus GO:0009615 9.97 CCL11 CCL5 IFNG TNF
4 positive regulation of gene expression GO:0010628 9.97 CCL3 IFNG IL13 IL4 IL6 TLR4
5 cellular response to interferon-gamma GO:0071346 9.95 CCL11 CCL3 CCL5 TLR4
6 defense response to Gram-negative bacterium GO:0050829 9.93 IL6 RNASE3 TLR4 TLR9
7 positive regulation of JNK cascade GO:0046330 9.92 TLR4 TLR9 TNF
8 neutrophil chemotaxis GO:0030593 9.92 CCL11 CCL3 CCL5 CXCL8
9 chemokine-mediated signaling pathway GO:0070098 9.92 CCL11 CCL3 CCL5 CXCL8
10 cellular response to organic cyclic compound GO:0071407 9.91 CCL3 CCL5 TNF
11 regulation of insulin secretion GO:0050796 9.91 CCL5 IFNG TNF
12 response to glucocorticoid GO:0051384 9.91 IL10 IL6 TNF
13 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TLR4 TLR9 TNF
14 positive regulation of T cell proliferation GO:0042102 9.9 CCL5 IL4 IL6
15 humoral immune response GO:0006959 9.9 IFNG IL6 TNF
16 positive regulation of interleukin-6 production GO:0032755 9.9 IL6 TLR4 TLR9 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.89 TLR4 TLR9 TNF
18 positive regulation of tumor necrosis factor production GO:0032760 9.89 CCL3 TLR4 TLR9
19 positive regulation of smooth muscle cell proliferation GO:0048661 9.89 CCL5 IL13 IL6 TNF
20 cellular response to interleukin-1 GO:0071347 9.89 CCL11 CCL3 CCL5 CXCL8 IL17A
21 positive regulation of nitric oxide biosynthetic process GO:0045429 9.88 IFNG TLR4 TNF
22 positive regulation of inflammatory response GO:0050729 9.88 CCL3 TLR10 TLR4 TLR9 TNF
23 protein kinase B signaling GO:0043491 9.87 CCL3 CCL5 TNF
24 toll-like receptor signaling pathway GO:0002224 9.87 TLR10 TLR4 TLR9
25 negative regulation of endothelial cell apoptotic process GO:2000352 9.87 IL10 IL13 IL4
26 monocyte chemotaxis GO:0002548 9.87 CCL11 CCL3 CCL5 IL6
27 lymphocyte chemotaxis GO:0048247 9.86 CCL11 CCL3 CCL5
28 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.85 TLR10 TLR4 TLR9
29 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 CCL5 IFNG IL13 IL4 IL6
30 positive regulation of interleukin-8 production GO:0032757 9.84 TLR4 TLR9 TNF
31 positive regulation of JAK-STAT cascade GO:0046427 9.84 CCL5 IL5 IL6
32 positive regulation of interleukin-12 production GO:0032735 9.83 IFNG TLR4 TLR9
33 lipopolysaccharide-mediated signaling pathway GO:0031663 9.83 CCL3 CCL5 TLR4 TNF
34 negative regulation of osteoclast differentiation GO:0045671 9.82 CCL3 IL4 TLR4
35 eosinophil chemotaxis GO:0048245 9.81 CCL11 CCL3 CCL5
36 positive regulation of osteoclast differentiation GO:0045672 9.81 IFNG IL17A TNF
37 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TLR9 TNF
38 regulation of cytokine secretion GO:0050707 9.78 TLR10 TLR4 TLR9
39 cytokine-mediated signaling pathway GO:0019221 9.77 CCL11 CCL3 CCL5 CXCL8 IGHE IL10
40 macrophage chemotaxis GO:0048246 9.76 CCL3 CCL5
41 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.76 CCL5 CXCL8
42 response to molecule of bacterial origin GO:0002237 9.76 CXCL8 IL10 TLR9
43 I-kappaB phosphorylation GO:0007252 9.75 TLR4 TLR9
44 negative regulation by host of viral transcription GO:0043922 9.75 CCL3 CCL5
45 negative regulation of interleukin-17 production GO:0032700 9.75 IFNG TLR4
46 positive regulation of immunoglobulin secretion GO:0051024 9.75 IL5 IL6
47 positive regulation of podosome assembly GO:0071803 9.75 IL5 TNF
48 neutrophil activation GO:0042119 9.75 CCL5 CXCL8
49 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.75 TLR4 TLR9 TNF
50 positive regulation of chemokine secretion GO:0090197 9.74 IL4R TNF

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL10 IL4 IL5 IL6
2 CCR5 chemokine receptor binding GO:0031730 9.4 CCL3 CCL5
3 cytokine activity GO:0005125 9.4 CCL11 CCL3 CCL5 CXCL8 IFNG IL10
4 phospholipase activator activity GO:0016004 9.37 CCL3 CCL5
5 CCR chemokine receptor binding GO:0048020 9.33 CCL11 CCL3 CCL5
6 CCR1 chemokine receptor binding GO:0031726 9.26 CCL3 CCL5
7 chemokine activity GO:0008009 9.26 CCL11 CCL3 CCL5 CXCL8
8 protein binding GO:0005515 10.36 CCL11 CCL3 CCL5 CXCL8 IFNG IL10

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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