MCID: BRN002
MIFTS: 61

Bronchiolitis

Categories: Respiratory diseases, Skin diseases

Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 56 6 3 45 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 45 D001988
NCIt 51 C39658
SNOMED-CT 69 4120002
UMLS 74 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and extrinsic allergic alveolitis, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Racepinephrine and Bromhexine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 77 Bronchiolitis is blockage of the small airways in the lungs due to a viral infection. It usually only... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 570)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 34.3 CXCL8 IFNG IL10 IL17A IL6 TNF
2 extrinsic allergic alveolitis 32.1 CCL2 CCL5 CXCL8 IL10 IL6
3 bronchitis 31.9 CCL11 CRP CXCL8 IL5 RNASE3 TNF
4 respiratory syncytial virus infectious disease 31.5 CCL3 CCL5 IL13 IL5
5 hematopoietic stem cell transplantation 31.2 IFNG IL10 IL6 TNF
6 chronic graft versus host disease 31.0 IFNG IL10 TNF
7 graft-versus-host disease 30.9 IFNG IL10 IL6 TNF
8 acute respiratory distress syndrome 30.5 CXCL8 IL6 TNF
9 pertussis 30.4 IL10 IL6 TLR4 TNF
10 arthritis 30.3 CCL2 CXCL8 IFNG IL10 IL17A IL6
11 chronic eosinophilic pneumonia 30.2 CCL11 CCL5 IL5 RNASE3
12 connective tissue disease 30.2 IFNG IL10 IL6 TNF
13 cytokine deficiency 30.2 IL13 IL5
14 bronchial disease 30.2 CCL11 CCL5 CXCL8 IL10 IL13 IL17A
15 interstitial lung disease 30.1 CCL2 CCL5 CXCL8 IFNG IL10 IL4
16 hyperlucent lung 30.1 IFNG IL10 IL4
17 eosinophilic pneumonia 30.0 CCL11 CCL5 IL13 IL5 RNASE3
18 colitis 30.0 CXCL8 IFNG IL10 IL17A IL4 IL6
19 juvenile rheumatoid arthritis 30.0 CRP IL6 TNF
20 viral pneumonia 29.9 CRP IL17A IL6
21 acute graft versus host disease 29.9 IFNG IL10 IL4 TNF
22 heart disease 29.9 CRP CXCL8 IL10 IL6 TNF
23 plasmodium vivax malaria 29.9 IFNG IL10 IL6 TNF
24 adult respiratory distress syndrome 29.9 CXCL8 IL10 IL6 TNF
25 cellulitis 29.9 IL5 RNASE3 TNF
26 castleman disease 29.9 CRP IFNG IL10 IL6
27 myasthenia gravis 29.9 IFNG IL10 IL4 TNF
28 cold agglutinin disease 29.8 CRP IL6
29 ascaridiasis 29.8 IL10 IL13
30 spondyloarthropathy 1 29.8 CRP IL17A TLR4 TNF
31 ascaris lumbricoides infection 29.8 IL13 IL5 IL6
32 nonspecific interstitial pneumonia 29.8 CCL2 IFNG IL13
33 spondylitis 29.8 CRP IL17A IL6 TNF
34 ulcerative colitis 29.8 CRP CXCL8 IFNG IL10 IL17A IL6
35 pulmonary sarcoidosis 29.7 CCL2 CCL5 IFNG TNF
36 cytomegalovirus infection 29.7 CCL2 CCL3 CCL5 CXCL8 IL6 TNF
37 melioidosis 29.7 IFNG IL10 IL6 TLR4 TNF
38 acute cystitis 29.7 CCL2 CRP CXCL8 IL6
39 pulmonary edema 29.7 CRP CXCL8 IL10 TNF
40 acquired immunodeficiency syndrome 29.7 CCL3 IFNG IL10 IL6 TNF
41 aspergillosis 29.6 IFNG IL10 IL4 IL5 TLR4 TNF
42 rheumatic disease 29.6 CRP IFNG IL10 TNF
43 hypereosinophilic syndrome 29.6 CCL11 IGHE IL13 IL4 IL5 RNASE3
44 sleep apnea 29.6 CRP CXCL8 IL6 TNF
45 common variable immunodeficiency 29.6 IFNG IL10 IL4 IL5 IL6 TNF
46 cholangitis 29.6 CRP IL6 TNF
47 synovitis 29.6 CRP CXCL8 IL6 TNF
48 human immunodeficiency virus infectious disease 29.5 CCL3 CCL5 IFNG IL10 IL6 TNF
49 idiopathic interstitial pneumonia 29.5 CCL2 CXCL8 IFNG IL13 IL4
50 pulmonary tuberculosis 29.5 CCL3 IFNG IL10 IL4 TNF

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

Symptoms:

12
  • fever
  • cough
  • wheezing
  • shortness of breath
  • nasal flaring in infants
  • bluish skin due to lack of oxygen

GenomeRNAi Phenotypes related to Bronchiolitis according to GeneCards Suite gene sharing:

27 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.53 CRP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.53 IL10
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.53 IL10
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.53 CRP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.53 MS4A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.53 TLR4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.53 MS4A2
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.53 IL10
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.53 IL10
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.53 CRP IL10 MS4A2 TLR4
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.53 MS4A2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.53 CRP MS4A2

MGI Mouse Phenotypes related to Bronchiolitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CCL11 CCL5 IFNG IL10 IL13 IL17A
2 immune system MP:0005387 10.13 CCL11 CCL2 CCL5 CRP IFNG IL10
3 digestive/alimentary MP:0005381 10.07 IFNG IL10 IL13 IL17A IL4 IL4R
4 integument MP:0010771 9.76 IFNG IL10 IL13 IL4 IL4R IL6
5 liver/biliary system MP:0005370 9.56 IFNG IL10 IL4 IL4R IL5 IL6
6 respiratory system MP:0005388 9.36 CCL11 IFNG IL10 IL13 IL17A IL4

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 260)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 329-65-7 838
2
Bromhexine Approved Phase 4 3572-43-8
3
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 51-43-4 5816
4
Prednisolone phosphate Approved, Vet_approved Phase 4,Not Applicable 302-25-0
5
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 4,Not Applicable 2921-57-5
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
9
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
10
Montelukast Approved Phase 4,Phase 3,Phase 2,Not Applicable 158966-92-8 5281040
11
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83905-01-5 447043 55185
12
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 22916-47-8 4189
13
Fluticasone Approved, Experimental Phase 4,Phase 2,Not Applicable 90566-53-3 62924
14
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 441411 12560
15
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-75-2 4033
16
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
17
Clarithromycin Approved Phase 4,Phase 3 81103-11-9 84029
18
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 53123-88-9 46835353 5284616 6436030
19
Prednisone Approved, Vet_approved Phase 4,Phase 1,Phase 2 53-03-2 5865
20
Azathioprine Approved Phase 4,Phase 2 446-86-6 2265
21
Everolimus Approved Phase 4,Phase 3,Phase 1,Phase 2 159351-69-6 70789204 6442177
22
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 104987-11-3 6473866 445643 439492
23
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
24
Macitentan Approved Phase 4 441798-33-0
25
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 50-14-6 5280793
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 1406-16-2
27
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 67-97-0 5280795 6221
28
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
29
Prednisolone hemisuccinate Experimental Phase 4,Not Applicable 2920-86-7
30 Epinephryl borate Phase 4,Phase 3,Phase 2,Not Applicable
31 Calamus Phase 4,Phase 3,Not Applicable
32 Sympathomimetics Phase 4,Phase 3,Phase 2,Not Applicable
33 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Adrenergic beta-Agonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
35 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
36 Bronchodilator Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
37 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Mydriatics Phase 4,Phase 3,Phase 2,Not Applicable
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Vasoconstrictor Agents Phase 4,Phase 3,Phase 2,Not Applicable
44 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
45 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Not Applicable
46 Ergocalciferols Phase 4,Phase 3,Phase 2,Not Applicable
47 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Vitamins Phase 4,Phase 3,Phase 2,Not Applicable
49 Nutrients Phase 4,Phase 3,Phase 2,Not Applicable
50 Trace Elements Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 363)
# Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in Bronchiolitis Unknown status NCT01216553 Phase 4
2 High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis Unknown status NCT03015051 Phase 4 Oxygen
3 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
4 Effect of Vitamin D Supplementation in Young South African Children Hospitalized With Acute Lower Respiratory Infection Unknown status NCT02054182 Phase 4 Vitamin D
5 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
6 Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
7 7% Hypertonic Saline for Acute Bronchiolitis Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
8 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
9 Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
10 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
11 Nebulized 3% Hypertonic Saline Solution Treatment of Bronchiolitis in Infants Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
12 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Bronchiolitis. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
13 Hypertonic Saline for Acute Bronchiolitis Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
14 Efficacy and Safety of 3% Hypertonic Saline Inhalation (24h vs 72h) to Treat Acute Bronchiolitis in Hospitalized Infants Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
15 Bronchodilator Responsiveness in Obliterative Bronchiolitis Completed NCT01112241 Phase 4 albuterol plus tiotropium
16 Vitamin D in Bronchiolitis Obliterans Syndrome Completed NCT01212406 Phase 4 Vitamin D
17 Impact of Oximetry on Hospitalization in Acute Bronchiolitis Completed NCT00673946 Phase 4
18 Montelukast in Bronchiolitis Obliterans Syndrome Completed NCT01211509 Phase 4 Montelukast
19 Use of Erythromycin in Mustard-Induced Bronchiolitis Completed NCT00367419 Phase 4 Erythromycin
20 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis Completed NCT00119002 Phase 4 dexamethasone;Placebo
21 Azithromycin in Bronchiolitis Obliterans Syndrome Completed NCT01009619 Phase 4 Azithromycin;Placebo
22 Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
23 Safety Study of Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
24 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
25 Effect of Addition Oral Montelukast to Standard Treatment in Acute Asthma in Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
26 Comparison of Sirolimus and Azathioprine in Lung Transplantation Completed NCT00321906 Phase 4 azathioprine;sirolimus
27 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
28 "Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial" Inpatient Hospital Use: A Randomized Controlled Trial" Not yet recruiting NCT03364218 Phase 4 N acetyl cysteine nebulized
29 Hypertonic Saline Inhalation in Acute Bronchiolitis Not yet recruiting NCT03880903 Phase 4 normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
30 Macitentan in the Treatment of Organ Rejection After Lung Transplantation Not yet recruiting NCT02893176 Phase 4 macitentan;placebo (for macitentan)
31 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
32 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
33 Treatment Of Bronchiolitis With Heated Humidified High Flow Nasal Cannula - Prospective And Retrospective Research Unknown status NCT02366715 Phase 3
34 Comparison Between 2l vs 3l in HFNC During the Initial Management of Severe Bronchiolitis in Infants Unknown status NCT02824744 Phase 3
35 Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis Unknown status NCT03053388 Phase 3 Nitric Oxide
36 The Efficacy of Azithromycin in Treating Children With Non Cystic Fibrosis Bronchiectasis Unknown status NCT02531984 Phase 3 Azithromycin
37 Lactobacillus Reuteri DSM 17938 and Prevention of Respiratory and Gastrointestinal Infections in Mexican Infants Unknown status NCT01249911 Phase 3
38 Heliox-Driven Racemic Epinephrine Nebulization in Treatment of Moderate to Severe Bronchiolitis in Pediatric ED Patients Completed NCT00116584 Phase 3 heliox
39 The SABRE Trial of Hypertonic Saline in Acute Bronchiolitis Completed NCT01469845 Phase 3
40 Nasal Irrigation in Infants With Bronchiolitis. Completed NCT02162745 Phase 3 Isotonic solution (NaCl 0.9%);Hypertonic solution (NaCl 3%)
41 An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272) Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo
42 Nebulized Hypertonic Saline for Bronchiolitis Completed NCT00619918 Phase 2, Phase 3 Nebulized 3% saline;Placebo
43 "Palivizumab Therapy for RSV-bronchiolitis" Completed NCT02442427 Phase 3 Palivizumab
44 Safety Study of Home Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
45 High Flow Therapy vs Hypertonic Saline in Bronchiolitis Completed NCT01873144 Phase 3 Epinephrine 1/1000;HSS 3%;NS (0.9%)
46 Single Dose Versus Multiple Doses of Dexamethasone in Children With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
47 Moderate to Severe Bronchiolitis: Standard Therapy Versus Therapy With NaCl 3% Inhalations Completed NCT01812525 Phase 3 NaCl 3%
48 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
49 Tacrolimus Versus Cyclosporine for Immunosuppression After Lung Transplantation Completed NCT01429844 Phase 3 Tacrolimus;Cyclosporine
50 Effect of Heliox on RSV Bronchiolitis Completed NCT03171142 Phase 3 Heliox;Air

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

42
Lung, Bone, Bone Marrow, Heart, Skin, T Cells, Testes

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 3529)
# Title Authors Year
1
Outcomes of Children With Critical Bronchiolitis Meeting at Risk for Pediatric Acute Respiratory Distress Syndrome Criteria. ( 30461577 )
2019
2
Interleukin-10 gene polymorphism rs1800896 is associated with post-bronchiolitis asthma at 11-13 years of age. ( 31074014 )
2019
3
Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: A multicenter prospective study. ( 30656708 )
2019
4
Anti-interleukin 5 antibody is effective for not only severe asthma and eosinophilic pneumonia but also eosinophilic bronchiolitis. ( 30574332 )
2019
5
Smoke Exposure, Cytokine Levels, and Asthma Visits in Children Hospitalized for Bronchiolitis. ( 30530718 )
2019
6
High-flow Oxygen Therapy for Treating Bronchiolitis in Infants. ( 30632653 )
2019
7
Estimating seasonal onsets and peaks of bronchiolitis with spatially and temporally uncertain data. ( 30637788 )
2019
8
Nebulised hypertonic saline in children with bronchiolitis admitted to the paediatric intensive care unit: A retrospective study. ( 30645038 )
2019
9
Barriers to Minimizing Respiratory Viral Testing in Bronchiolitis: Physician Perceptions on Testing Practices. ( 30647087 )
2019
10
Constrictive Bronchiolitis Obliterans in a Dog. ( 30653359 )
2019
11
Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis. ( 30654045 )
2019
12
High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis. ( 30655267 )
2019
13
Towards Personalized Medicine in Bronchiolitis. ( 30657699 )
2019
14
Inappropriate Antibiotic Prescribing for Acute Bronchiolitis in US Emergency Departments, 2007-2015. ( 30657968 )
2019
15
Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome. ( 30663178 )
2019
16
Association of Fluid Overload With Clinical Outcomes in Critically Ill Children With Bronchiolitis: Bronquiolitis en la Unidad de Cuidados Intensivos Pediátricos (BRUCIP) Study. ( 30664037 )
2019
17
Predicting Appropriate Hospital Admission of Emergency Department Patients with Bronchiolitis: Secondary Analysis. ( 30668518 )
2019
18
Ruxolitinib is an effective steroid sparing agent in children with steroid refractory/dependent bronchiolitis obliterans syndrome after allogenic hematopoietic cell transplantation. ( 30683905 )
2019
19
Association of Diagnostic Criteria With Urinary Tract Infection Prevalence in Bronchiolitis: A Systematic Review and Meta-analysis. ( 30688987 )
2019
20
The role of HIF-1α-VEGF pathway in bronchiolitis obliterans after lung transplantation. ( 30696477 )
2019
21
Continuous positive airway pressure (CPAP) for acute bronchiolitis in children. ( 30701528 )
2019
22
Freire G, Kuppermann N, Zemek R, et al; Pediatric Emergency Research Networks (PERN). Predicting Escalated Care in Infants With Bronchiolitis. Pediatrics. 2018;142(3):e20174253. ( 30705143 )
2019
23
Outcomes of Children With Bronchiolitis Treated With High-Flow Nasal Cannula or Noninvasive Positive Pressure Ventilation. ( 30720646 )
2019
24
Noninvasive High Flow Versus Noninvasive Positive Pressure in Children With Severe Bronchiolitis: The Battle of the PICU Continues. ( 30720651 )
2019
25
Canadian and UK/Ireland practice patterns in lumbar puncture performance in febrile neonates with bronchiolitis. ( 30728189 )
2019
26
Inhibition of B cell-dependent lymphoid follicle formation prevents lymphocytic bronchiolitis after lung transplantation. ( 30728330 )
2019
27
Bronchiolitis obliterans syndrome 'endotypes' in haematopoietic stem cell transplantation. ( 30730090 )
2019
28
Bronchiolitis Obliterans After Cefuroxime-Induced Stevens-Johnson Syndrome. ( 30737366 )
2019
29
Follicular bronchiolitis, a frequently misdiagnosed condition. ( 30745245 )
2019
30
Point-of-care lung ultrasound in infants with bronchiolitis in the pediatric emergency department: a prospective study. ( 30747262 )
2019
31
Monoclonal Antibody Treatment of RSV Bronchiolitis in Young Infants: A Randomized Trial. ( 30760509 )
2019
32
Hospitalization for Respiratory Syncytial Virus Bronchiolitis in the Palivizumab Prophylaxis Era: Need for Reconsideration of Preventive Timing and Eligibility. ( 30772962 )
2019
33
The syndrome we agreed to call bronchiolitis. ( 30783666 )
2019
34
Combination of pleuroparenchymal fibroelastosis with non-specific interstitial pneumonia and bronchiolitis obliterans as a complication of hematopoietic stem cell transplantation - Clues to a potential mechanism. ( 30792952 )
2019
35
Diagnosing and managing bronchiolitis obliterans in children. ( 30798629 )
2019
36
Fluid Overload in Children With Bronchiolitis. ( 30830024 )
2019
37
Lung ultrasound for prediction of respiratory support in infants with acute bronchiolitis: A cohort study. ( 30838805 )
2019
38
Timely Data for Targeted Quality Improvement Interventions: Use of a Visual Analytics Dashboard for Bronchiolitis. ( 30841007 )
2019
39
Preschool respiratory hospital admissions following infant bronchiolitis: a birth cohort study. ( 30842095 )
2019
40
Distinct transcriptional modules in the peripheral blood mononuclear cells response to human respiratory syncytial virus or to human rhinovirus in hospitalized infants with bronchiolitis. ( 30845274 )
2019
41
Prenatal exposure to acid suppressant medications and the risk of recurrent wheeze at 3 years of age in children with a history of severe bronchiolitis. ( 30878709 )
2019
42
A Case of Bilateral Spontaneous Chylothorax with Respiratory Syncytial Virus Bronchiolitis. ( 30881718 )
2019
43
Transient Tachypnea of the Newborn Is Associated With an Increased Risk of Hospitalization Due to Respiratory Syncytial Virus Bronchiolitis. ( 30882737 )
2019
44
Precision medicine: integration of genetics and functional genomics in prediction of bronchiolitis obliterans after lung transplantation. ( 30883449 )
2019
45
A pilot study of heated and humidified low flow oxygen therapy: An assessment in infants with mild and moderate bronchiolitis (HHOT AIR study). ( 30887708 )
2019
46
Comparison of heated humidified high-flow nasal cannula flow rates (1-L·kg·min-1 vs 2-L·kg·min -1 ) in the management of acute bronchiolitis. ( 30887731 )
2019
47
EXERCISE CAPACITY IN CHILDREN AND ADOLESCENTS WITH POST-INFECTIOUS BRONCHIOLITIS OBLITERANS: A SYSTEMATIC REVIEW. ( 30892545 )
2019
48
Sporadic Obliterative Bronchiolitis: Case Series and Systematic Review of the Literature. ( 30899912 )
2019
49
Bronchiolitis Obliterans as long-term sequela of non-drug related Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in children. ( 30908698 )
2019
50
Safety of High-Flow Nasal Cannula Outside Intensive Care Units for Previously Healthy Children With Bronchiolitis. ( 30914486 )
2019

Variations for Bronchiolitis

ClinVar genetic disease variations for Bronchiolitis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;XX;t(2;3)(q34;p23) Translocation Likely pathogenic
2 46;XY;t(16;20)(q23.1;p11.22) Translocation Uncertain significance

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.13 CCL11 CCL2 CCL3 CCL5 CRP CXCL8
2
Show member pathways
13.98 CCL11 CCL2 CCL3 CCL5 CXCL8 IL10
3
Show member pathways
13.81 CCL11 CCL2 CCL3 CCL5 CXCL8 IFNG
4
Show member pathways
13.69 CCL11 CCL2 CCL3 CCL5 CXCL8 IFNG
5
Show member pathways
13.58 CCL11 CCL2 CCL3 CCL5 CXCL8 IL10
6
Show member pathways
13.5 CCL11 CCL2 CCL3 CCL5 CXCL8 IFNG
7
Show member pathways
13.47 CCL11 CCL2 CCL3 CCL5 CXCL8 IL10
8
Show member pathways
13.25 CCL2 CCL3 CCL5 CXCL8 IFNG IL10
9
Show member pathways
13.07 CCL2 CCL3 CCL5 CXCL8 IL6 TLR4
10
Show member pathways
12.99 CCL11 CXCL8 IFNG IL10 IL13 IL17A
11 12.98 CXCL8 IFNG IL13 IL4 IL4R IL5
12
Show member pathways
12.87 CCL5 CXCL8 IFNG IL6 TLR4 TNF
13
Show member pathways
12.81 IFNG IL10 IL13 IL17A IL4 IL4R
14
Show member pathways
12.79 IFNG IGHE IL10 IL4 IL4R MS4A2
15 12.74 CCL2 CCL5 IFNG IL10 IL17A IL4
16
Show member pathways
12.74 IFNG IL10 IL17A IL4 IL5 IL6
17
Show member pathways
12.73 CCL2 IFNG IL10 IL17A IL6 TNF
18
Show member pathways
12.72 IGHE IL13 IL4 IL5 MS4A2 TNF
19
Show member pathways
12.58 IFNG IL10 IL13 IL4 IL4R IL5
20
Show member pathways
12.53 CCL2 CCL5 CRP IFNG IL4 IL6
21
Show member pathways
12.51 CCL11 CCL2 CXCL8 IFNG IL13 IL17A
22
Show member pathways
12.47 CXCL8 IFNG IL10 IL13 IL17A IL4
23
Show member pathways
12.44 CCL11 IGHE IL4 IL4R
24
Show member pathways
12.43 CXCL8 IFNG IL6 TLR4 TNF
25
Show member pathways
12.39 IFNG IL10 IL4 TLR4 TNF
26
Show member pathways
12.39 CCL11 CXCL8 IFNG IL4 IL6 TLR4
27 12.37 IFNG IL10 IL6 TLR4 TNF
28
Show member pathways
12.33 CXCL8 IL6 TLR4 TNF
29
Show member pathways
12.32 CCL11 CCL2 CCL3 CCL5 CXCL8 TLR4
30 12.32 CXCL8 IL10 IL13 IL6 TNF
31 12.27 IFNG IL6 TLR4 TNF
32
Show member pathways
12.25 IFNG IL10 IL17A IL6 TLR4 TNF
33 12.24 CCL2 CXCL8 IFNG IL4 IL6 TLR4
34
Show member pathways
12.23 IFNG IL13 IL4 IL6 TLR4 TNF
35
Show member pathways
12.23 CCL11 CCL2 CCL3 CCL5 CXCL8 IFNG
36 12.19 IFNG IL10 IL4 IL5 IL6 TNF
37
Show member pathways
12.17 CCL11 CCL2 CCL3 CCL5 CXCL8
38 12.12 CCL11 CCL2 CXCL8 IGHE IL10 IL13
39 12.1 CXCL8 IFNG IL10 IL6 TLR4 TNF
40 12.08 CCL2 CCL5 IL6 TNF
41 12.07 IL4 IL4R IL5 IL6 TNF
42 12.06 CCL3 CXCL8 IFNG IL6
43 12.03 CCL2 CXCL8 IL6 TNF
44 12.03 CXCL8 IFNG IL13 IL4 IL5 IL6
45 12.03 CCL3 IFNG IL10 IL13 IL17A IL4
46 12.02 CCL3 CXCL8 IFNG IL6 TLR4
47
Show member pathways
12 CXCL8 IL17A IL6 TLR4
48 11.99 IFNG IL10 IL4R IL6
49
Show member pathways
11.96 CXCL8 IFNG IL4 IL5 TNF
50 11.95 CXCL8 IL10 IL6 TLR4 TNF

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 CCL11 CCL2 CCL3 CCL5 CRP CXCL8
2 external side of plasma membrane GO:0009897 9.63 IGHE IL13 IL17A MS4A2 TLR4 TNF
3 extracellular space GO:0005615 9.53 CCL11 CCL2 CCL3 CCL5 CRP CXCL8

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Name GO ID Score Top Affiliating Genes
1 cellular response to lipopolysaccharide GO:0071222 9.99 CCL2 CXCL8 IL10 IL6 TLR4 TNF
2 positive regulation of DNA-binding transcription factor activity GO:0051091 9.98 IL10 IL5 IL6 TNF
3 response to virus GO:0009615 9.97 CCL11 CCL5 IFNG TNF
4 defense response to Gram-positive bacterium GO:0050830 9.96 CRP IL6 RNASE3 TNF
5 cellular response to interferon-gamma GO:0071346 9.95 CCL11 CCL2 CCL3 CCL5 TLR4
6 cellular response to organic cyclic compound GO:0071407 9.93 CCL2 CCL3 CCL5 TNF
7 neutrophil chemotaxis GO:0030593 9.93 CCL11 CCL2 CCL3 CCL5 CXCL8
8 cell chemotaxis GO:0060326 9.92 CCL2 CCL3 CCL5
9 defense response to Gram-negative bacterium GO:0050829 9.92 IL6 RNASE3 TLR4
10 humoral immune response GO:0006959 9.92 CCL2 IFNG IL6 TNF
11 chemokine-mediated signaling pathway GO:0070098 9.92 CCL11 CCL2 CCL3 CCL5 CXCL8
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.91 CCL5 IL13 IL6 TNF
13 positive regulation of inflammatory response GO:0050729 9.9 CCL3 TLR4 TNF
14 regulation of insulin secretion GO:0050796 9.9 CCL5 IFNG TNF
15 response to glucocorticoid GO:0051384 9.9 IL10 IL6 TNF
16 positive regulation of T cell proliferation GO:0042102 9.89 CCL5 IL4 IL6
17 positive regulation of interleukin-6 production GO:0032755 9.89 IL6 TLR4 TNF
18 positive regulation of B cell proliferation GO:0030890 9.89 IL13 IL4 IL5 TLR4
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 CCL5 IFNG IL13 IL4 IL6
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG TLR4 TNF
21 negative regulation of endothelial cell apoptotic process GO:2000352 9.87 IL10 IL13 IL4
22 protein kinase B signaling GO:0043491 9.87 CCL2 CCL3 CCL5 TNF
23 lymphocyte chemotaxis GO:0048247 9.86 CCL11 CCL2 CCL3 CCL5
24 cellular response to fibroblast growth factor stimulus GO:0044344 9.85 CCL2 CCL5 CXCL8
25 negative regulation of interleukin-6 production GO:0032715 9.85 IL10 TLR4 TNF
26 positive regulation of JAK-STAT cascade GO:0046427 9.84 CCL5 IL5 IL6
27 negative regulation of osteoclast differentiation GO:0045671 9.83 CCL3 IL4 TLR4
28 positive regulation of osteoclast differentiation GO:0045672 9.82 IFNG IL17A TNF
29 positive regulation of chemokine production GO:0032722 9.81 IL6 TLR4 TNF
30 macrophage chemotaxis GO:0048246 9.8 CCL2 CCL3 CCL5
31 eosinophil chemotaxis GO:0048245 9.8 CCL11 CCL2 CCL3 CCL5
32 monocyte chemotaxis GO:0002548 9.8 CCL11 CCL2 CCL3 CCL5 IL6
33 cellular response to interleukin-1 GO:0071347 9.8 CCL11 CCL2 CCL3 CCL5 CXCL8 IL17A
34 inflammatory response GO:0006954 9.8 CCL11 CCL2 CCL3 CCL5 CRP CXCL8
35 negative regulation of lipid storage GO:0010888 9.77 CRP IL6 TNF
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 CCL2 CCL3 CCL5 TLR4 TNF
37 positive regulation of macrophage activation GO:0043032 9.76 IL10 IL13 IL4R TLR4
38 positive regulation of MHC class II biosynthetic process GO:0045348 9.75 IL10 IL4 TLR4
39 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.74 CCL5 CXCL8
40 negative regulation by host of viral transcription GO:0043922 9.74 CCL3 CCL5
41 negative regulation of interleukin-17 production GO:0032700 9.74 IFNG TLR4
42 PERK-mediated unfolded protein response GO:0036499 9.74 CCL2 CXCL8
43 positive regulation of immunoglobulin secretion GO:0051024 9.74 IL5 IL6
44 positive regulation of podosome assembly GO:0071803 9.73 IL5 TNF
45 response to molecule of bacterial origin GO:0002237 9.73 CXCL8 IL10
46 neutrophil activation GO:0042119 9.73 CCL5 CXCL8
47 positive regulation of chemokine secretion GO:0090197 9.73 IL4R TNF
48 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.73 TLR4 TNF
49 positive regulation of mast cell degranulation GO:0043306 9.72 IL13 IL4R
50 endothelial cell apoptotic process GO:0072577 9.72 IL10 TNF

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.62 IL10 IL4 IL5 IL6
2 CCR chemokine receptor binding GO:0048020 9.46 CCL11 CCL2 CCL3 CCL5
3 cytokine activity GO:0005125 9.44 CCL11 CCL2 CCL3 CCL5 CXCL8 IFNG
4 CCR5 chemokine receptor binding GO:0031730 9.4 CCL3 CCL5
5 phospholipase activator activity GO:0016004 9.37 CCL3 CCL5
6 chemokine activity GO:0008009 9.35 CCL11 CCL2 CCL3 CCL5 CXCL8
7 CCR1 chemokine receptor binding GO:0031726 9.26 CCL3 CCL5
8 protein binding GO:0005515 10.36 CCL11 CCL2 CCL3 CCL5 CRP CXCL8

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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