MCID: BRN002
MIFTS: 57

Bronchiolitis

Categories: Respiratory diseases, Skin diseases

Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 54 6 3 44 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 44 D001988
NCIt 50 C39658
SNOMED-CT 67 4120002
UMLS 70 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to cryptogenic organizing pneumonia and bronchiolitis obliterans, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and heart, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 73 Bronchiolitis is blockage of the small airways in the lungs due to a viral infection. It usually only... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 938)
# Related Disease Score Top Affiliating Genes
1 cryptogenic organizing pneumonia 33.1 TNF SFTPD CXCL8
2 bronchiolitis obliterans 32.7 TNF TLR4 SFTPD IL6 IL17A IL13
3 idiopathic interstitial pneumonia 31.7 SFTPD IL4 IL13 IFNG CXCL8
4 silo filler's disease 31.7 TLR4 SFTPD IL5 IL17A
5 chronic graft versus host disease 31.5 IL10 IFNG CCL5
6 graft-versus-host disease 31.5 TNF IL6 IL10 IFNG
7 bronchitis 31.2 TNF TLR4 RNASE3 IL6 IL5 IL4
8 cytokine deficiency 31.2 IL5 IL13
9 pemphigus 31.1 TNF IL6 IL4 IL10
10 human cytomegalovirus infection 31.0 IL6 CXCL8 CCL5
11 ige responsiveness, atopic 31.0 RNASE3 IL5 IL4R IL4 IL13 IL10
12 pulmonary fibrosis 30.9 SFTPD IL13 CXCL8 CCL3
13 haemophilus influenzae 30.8 TNF CXCL8
14 acute graft versus host disease 30.8 TNF IL4 IL10 IFNG
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.8 IL17A IL10 IFNG
16 acute asthma 30.8 RNASE3 IL5 IL4
17 adult respiratory distress syndrome 30.8 TNF SFTPD IL6 IL10 CXCL8
18 vascular disease 30.7 TNF TLR4 IL6 IL10 IFNG
19 connective tissue disease 30.7 TNF SFTPD IL6 IL4 IL17A IL10
20 erythema multiforme 30.6 TNF IL6 IL5 IL4 IFNG CXCL8
21 aspiration pneumonia 30.6 TNF IL6 IL17A
22 gastroesophageal reflux 30.6 TNF IL6 IL5 IL4 CXCL8 CCL11
23 respiratory failure 30.6 TNF TLR4 SFTPD RNASE3 IL6 IL5
24 histiocytosis 30.6 TNF IL17A IFNG
25 pulmonary edema 30.6 TNF IL13 IL10 CXCL8
26 acute cystitis 30.6 TNF TLR4 IL6 IL10 CXCL8
27 pulmonary emphysema 30.5 SFTPD IFNG CXCL8
28 bronchial disease 30.5 TNF TLR4 RNASE3 IL6 IL5 IL4R
29 pertussis 30.5 TNF TLR4 IL6 IL10 CXCL8 CCL5
30 castleman disease 30.4 IL6 IL10 IFNG
31 interstitial lung disease 30.4 TNF SFTPD IL6 IL5 IL4 IL17A
32 lymphopenia 30.4 IL6 IL4 IL10 IFNG
33 bacteriuria 30.4 TLR4 IL6 CXCL8
34 nonspecific interstitial pneumonia 30.4 SFTPD IL13 IFNG
35 rheumatoid arthritis interstitial lung disease 30.4 TNF SFTPD
36 ulcerative colitis 30.4 TNF TLR4 IL6 IL4 IL17A IL13
37 measles 30.3 TNF TLR4 TLR3 IL6 IFNG IFNA1
38 lung abscess 30.3 TNF IL6 IFNG
39 bronchopneumonia 30.3 TNF TLR4 IL6 IL17A IL10 CXCL8
40 cardiogenic shock 30.3 TNF IL6
41 extrinsic allergic alveolitis 30.3 SFTPD IL6 IL10 CXCL8 CCL5 CCL3
42 spondyloarthropathy 1 30.3 TNF TLR4 IL6 IL17A
43 exanthem 30.3 TNF IL6 IL10 IFNG IFNA1 CXCL8
44 eosinophilic pneumonia 30.3 SFTPD RNASE3 IL5 IL4 IL13 CXCL8
45 cryptococcosis 30.3 TNF IL4 IL17A IL13 IL10 IFNG
46 common variable immunodeficiency 30.3 TNF IL6 IL5 IL4 IL10 IFNG
47 juvenile rheumatoid arthritis 30.3 TNF IL6 IL10 IFNG CXCL8 CCL5
48 spondylitis 30.3 TNF IL6 IL17A IL10 IFNG
49 mixed connective tissue disease 30.2 TNF IL6 IL10 IFNG
50 chronic asthma 30.2 RNASE3 IL5 IL4 IL13 CCL11

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

Symptoms:

12
  • fever
  • cough
  • wheezing
  • shortness of breath
  • nasal flaring in infants
  • bluish skin due to lack of oxygen

MGI Mouse Phenotypes related to Bronchiolitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.21 CCL11 CCL5 IFNG IL10 IL13 IL17A
2 immune system MP:0005387 10.17 CCL11 CCL5 IFNG IL10 IL13 IL17A
3 digestive/alimentary MP:0005381 10.1 IFNG IL10 IL13 IL17A IL4 IL4R
4 integument MP:0010771 9.91 IFNG IL10 IL13 IL17A IL4 IL4R
5 liver/biliary system MP:0005370 9.76 IFNG IL10 IL4 IL4R IL5 IL6
6 neoplasm MP:0002006 9.5 IFNG IL10 IL5 IL6 TLR3 TLR4
7 respiratory system MP:0005388 9.44 CCL11 IFNG IL10 IL13 IL17A IL4

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 172)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromhexine Approved Phase 4 3572-43-8
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
8
Azithromycin Approved Phase 4 83905-01-5 55185 447043
9
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
10
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
11
Clarithromycin Approved Phase 4 81103-11-9 84029
12
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
13
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
14
Montelukast Approved Phase 4 158966-92-8 5281040
15
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
17
Lysine Approved, Nutraceutical Phase 4 56-87-1 5962
18
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
19
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
20 Vitamin D2 Phase 4
21 Ergocalciferols Phase 4
22 Methylprednisolone Acetate Phase 4
23 Neuroprotective Agents Phase 4
24 Micronutrients Phase 4
25 Trace Elements Phase 4
26 Nutrients Phase 4
27 Vitamins Phase 4
28 Calciferol Phase 4
29 Anticonvulsants Phase 4
30 Dermatologic Agents Phase 4
31 Olive Phase 4
32 Cholinergic Agents Phase 4
33 Parasympatholytics Phase 4
34 Cholinergic Antagonists Phase 4
35 Bromides Phase 4
36 Tiotropium Bromide Phase 4 136310-93-5
37 Anti-Allergic Agents Phase 4
38 Cytochrome P-450 CYP3A Inhibitors Phase 4
39 Cytochrome P-450 Enzyme Inhibitors Phase 4
40 Erythromycin Ethylsuccinate Phase 4
41 Erythromycin Estolate Phase 4
42 Erythromycin stearate Phase 4
43 Pharmaceutical Solutions Phase 4
44 Protective Agents Phase 4
45 Anti-Infective Agents Phase 4
46 Antiviral Agents Phase 4
47 Antioxidants Phase 4
48 Antidotes Phase 4
49 Expectorants Phase 4
50 N-monoacetylcystine Phase 4

Interventional clinical trials:

(show top 50) (show all 320)
# Name Status NCT ID Phase Drugs
1 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
2 Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis Unknown status NCT01216553 Phase 4
3 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
4 Impact of Oximetry on Hospitalization Completed NCT00673946 Phase 4
5 A Randomized Trial of Nebulized 3% Hypertonic Saline With Salbutamol in the Treatment of Acute Bronchiolitis in Pediatric Hospital Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
6 Impact of the Administration of Systemic Glucocorticoids on Inflammatory Response and Clinical Evolution of Patients Diagnosed With Moderate- Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
7 A Randomized Double Blind Placebo Controlled Trial With Vitamin D to Prevent Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01212406 Phase 4 Vitamin D
8 Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
9 Randomized Double-blind Placebo-controlled Prevention Trial of Azithromycin in Lung Transplantation. Completed NCT01009619 Phase 4 Azithromycin;Placebo
10 Acute Bronchodilator Responsiveness in Obliterative Bronchiolitis (OB) Following Hematopoietic Stem Cell Transplantation Completed NCT01112241 Phase 4 albuterol plus tiotropium
11 Nebulized Hypertonic Saline for Acute Bronchiolitis in the Emergency Department Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
12 A Randomized, Double Blind, Placebo Controlled Trial With Montelukast to Treat Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01211509 Phase 4 Montelukast
13 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis: A Multicenter Randomized Controlled Trial Completed NCT00119002 Phase 4 dexamethasone;Placebo
14 Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans Completed NCT00367419 Phase 4 Erythromycin
15 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
16 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
17 Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
18 Effects of Reduction of the Length of Treatment by Nebulized 3% Hypertonic Saline From 72 to 24 Hours on Clinical Remission, in Children Younger Than 12 Month Hospitalized for Acute Bronchiolitis. BRONDUSAL Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
19 7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
20 Pilot Study: Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
21 A Prospective, Open-label Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
22 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
23 Phase 4 Study of Oral Montelukast Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
24 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Completed NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
25 Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial Recruiting NCT03364218 Phase 4 N-Acetyl Cysteine
26 Effectiveness of Montelukast in Children With Recurrent Obstructive Bronchitis Active, not recruiting NCT04613180 Phase 4 Montelukast Sodium;Placebo
27 A Prospective Study on the Use of Hypertonic Saline Inhalation in Acute Bronchiolitis in Children Not yet recruiting NCT03880903 Phase 4 normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
28 Dexamethasone Use for the Treatment of Non-RSV Bronchiolitis Suspended NCT04221087 Phase 4 Placebos;Dexamethasone Oral
29 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
30 Randomized Controlled Trial to Compare the Efficacy of High Flow Nasal Cannula Oxygen Therapy vs Low Flow Oxygen Therapy in Bronchiolitis Terminated NCT03015051 Phase 4 Oxygen
31 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
32 IMLEMENTATION OF High Flow Nasal Cannulae Therapy FOR THE TREATMENT OF BRONCHIOLITIS IN A GENERAL PEDIATRIC WARD - A RETROSPECTIVE AND PROSPECTIVE CLINICAL TRIAL Unknown status NCT02366715 Phase 3
33 Comparison Between 2l/Min/kg vs 3l/Min/kg in High Flow Nasal Cannula (HFNC) During the Initial Management of Severe Bronchiolitis in Infants Unknown status NCT02824744 Phase 3
34 A Randomised Controlled Trial: Home Oxygen Therapy Versus Hospital Oxygen Therapy for Children With Acute Bronchiolitis Completed NCT00677066 Phase 3
35 Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients: a Double-Blind Randomized Study Completed NCT00512811 Phase 3 furosemide
36 Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard Completed NCT00642447 Phase 2, Phase 3 helium:oxygen mixture
37 Nebulized Hypertonic Saline for Treatment of Viral Bronchiolitis Completed NCT00619918 Phase 2, Phase 3 Nebulized 3% saline;Placebo
38 Nebulized Hypertonic Saline in the Treatment of Bronchiolitis in Infants Completed NCT00151905 Phase 2, Phase 3 3 % hypertonic saline
39 Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
40 The Use of Heliox Driven Racemic Epinephrine Nebulization in the Treatment of Moderate to Severe Bronchiolitis in Pediatric Emergency Department Patients Completed NCT00116584 Phase 3 heliox;oxygen
41 A Multi-Center, Randomized, Controlled Study to Demonstrate the Efficacy and Safety of Cyclosporine Inhalation Solution (CIS) in Improving Bronchiolitis Obliterans Syndrome-Free Survival Following Lung Transplantation Completed NCT00755781 Phase 3 Cyclosporine Inhalation Solution (CIS)
42 Randomized, Open-label, Multi-Center Study Comparing Tacrolimus With Cyclosporin, Both Arms in Combination With Mycophenolate Mofetil and Corticosteroids for Prevention of Bronchiolitis Obliterans Syndrome in Lung Transplant Patients Completed NCT01429844 Phase 3 Tacrolimus;Cyclosporine
43 A European Multi-center, Randomised, Double-blind Trial of Pirfenidone in Bronchiolitis-obliterans-syndrome Grade 1-3 in Lung Transplant Recipients Completed NCT02262299 Phase 2, Phase 3 Pirfenidone;Placebo
44 A Randomized, Double Blind, Placebo Controlled Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans Syndrome in Bilateral Lung and Single Lung Transplant Patients Completed NCT00188825 Phase 3 basiliximab
45 High Flow Therapy vs Hypertonic Saline in Bronchiolitis Treatment. Randomized Controlled Trial Completed NCT01873144 Phase 3 Epinephrine 1/1000;HSS 3%;NS (0.9%)
46 Phase III, Randomized, Double Blind Study of Low Dose Long Term Clarithromycin Versus Placebo in Treatment of Chronic Pulmonary Lesions Due to Sulfur Mustard Completed NCT00381147 Phase 3 Clarithromycin
47 3% Hypertonic Saline to Reduce Hospitalization Rate in Acute Viral Bronchiolitis: a Randomized Double Blind Clinical Trial Completed NCT01777347 Phase 3 3% Saline;0.9% Normal Saline
48 Randomized Double-blind Placebo-controlled, Parallel, Multi Centre Clinical Trial of Sublingual Bacterial Vaccine in Children With Recurrent Bronchospasm (Wheezing Attacks) for the Evaluation of Efficacy, Security and Clinical Impact. Completed NCT01734811 Phase 3
49 Treatment of Respiratory Syncytial Virus Bronchiolitis in Young Infants With Humanized Monoclonal Antibody: A Randomized Clinical Trial (Palivizumab Study) Completed NCT02442427 Phase 3 Palivizumab
50 Hypertonic Saline in Acute Bronchiolitis: Randomised Controlled Trial and Economic Evaluation Completed NCT01469845 Phase 3

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

40
Lung, Bone Marrow, Heart, T Cells, Neutrophil, Skin, Bone

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 11333)
# Title Authors PMID Year
1
Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. 54 61
19773677 2009
2
Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. 54 61
19005677 2009
3
[Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. 54 61
19470255 2009
4
[Relationship of levels of CD4(+)CD25(+) regulatory T cells and expression of Foxp3 mRNA in peripheral blood with serum immunoglobulin E level in children with bronchiolitis]. 54 61
19470254 2009
5
[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]. 54 61
19567118 2009
6
[Association of INF-gamma/A+874T gene polymorphisms with respiratory syncytial virus bronchiolitis]. 54 61
19149916 2009
7
[Association between interleukin-8 gene-251 locus polymorphism and respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infants]. 61 54
18282421 2007
8
Immunopathogenesis of respiratory syncytial virus bronchiolitis. 61 54
17436234 2007
9
Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. 54 61
17356094 2007
10
Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. 54 61
17297249 2007
11
[Genetic polymorphisms and infections]. 61 54
16697544 2006
12
Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. 61 54
16503988 2006
13
Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. 61 54
16192901 2005
14
Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis. 61 54
15898980 2005
15
Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. 61 54
15765744 2005
16
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. 54 61
15356575 2004
17
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. 54 61
15085176 2004
18
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. 54 61
15161635 2004
19
Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. 61 54
15144474 2004
20
Haplotype mapping of the bronchiolitis susceptibility locus near IL8. 61 54
14605870 2004
21
Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. 54 61
14722888 2004
22
Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. 61 54
12847481 2003
23
Respiratory syncytial virus and other respiratory viruses. 61 54
12671447 2003
24
Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus. 61 54
14736212 2003
25
Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. 54 61
12508140 2003
26
The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis. 54 61
15366660 2003
27
Steroids fail to down-regulate respiratory syncytial virus-induced IL-8 secretion in infants. 54 61
12193669 2002
28
RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants. 61 54
12027066 2002
29
DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. 61 54
11716180 2001
30
Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. 54 61
11431705 2001
31
Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. 54 61
11389573 2001
32
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. 54 61
10489841 1999
33
Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. 54 61
10351940 1999
34
Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma? 61 54
9920219 1998
35
Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing. 54 61
9261851 1997
36
Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis. 61 54
9220520 1997
37
Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. 54 61
9041319 1997
38
Persistence of respiratory syncytial virus (RSV) infection and development of RSV-specific IgG1 response in a guinea-pig model of acute bronchiolitis. 54 61
9032486 1997
39
Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis. 61 54
9151339 1996
40
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. 54 61
7841728 1994
41
Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease. 61 54
8087190 1994
42
Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus. 54 61
8087188 1994
43
Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. 54 61
1731020 1992
44
Risk assessment of inhaled diacetyl from electronic cigarette use among teens and adults. 61
33770882 2021
45
Native Lung Pulmonary Artery Banding After Single-Lung Transplant for Obliterative Bronchiolitis. 61
32950493 2021
46
Lung function trajectories and bronchial hyperresponsiveness during childhood following severe RSV bronchiolitis in infancy. 61
33098584 2021
47
Hyponatremia in Acute Bronchiolitis. 61
33409953 2021
48
Concurrent Reductions in Spirometry Predict Mortality and Bronchiolitis Obliterans in Chronic Graft-versus-Host Disease. 61
33147422 2021
49
Determinants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: a national cohort study. 61
32827056 2021
50
Enough Is Enough: Quality Improvement to Deimplement High-Flow Nasal Cannula in Bronchiolitis. 61
33753361 2021

Variations for Bronchiolitis

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 TNF TLR4 TLR3 RNASE3 IL6 IL5
2
Show member pathways
13.96 TNF IL6 IL5 IL4R IL4 IL17A
3
Show member pathways
13.78 TNF TLR4 IL6 IL5 IL4R IL4
4
Show member pathways
13.69 TNF IL6 IL5 IL4R IL4 IL17A
5
Show member pathways
13.52 TNF TLR4 TLR3 IL6 IL5 IL4R
6
Show member pathways
13.48 TNF IL6 IL5 IL4R IL4 IL17A
7
Show member pathways
13.38 TNF TLR4 TLR3 SFTPD IL6 IL10
8
Show member pathways
13.35 TNF IL6 IL5 IL4R IL4 IL17A
9
Show member pathways
13.11 TNF TLR4 TLR3 IL6 IL4R IL4
10
Show member pathways
13.1 TNF TLR4 TLR3 IL6 IFNA1 CXCL8
11 13.01 IL6 IL5 IL4R IL4 IL13 IFNG
12
Show member pathways
12.99 TNF TLR4 TLR3 IL6 IFNG IFNA1
13
Show member pathways
12.92 TNF RNASE3 IL6 IL5 IL4 IL17A
14 12.91 TNF TLR3 IL6 IFNG IFNA1 CCL5
15
Show member pathways
12.9 TNF TLR4 TLR3 IL4R IL4 IFNG
16
Show member pathways
12.8 TNF TLR4 IL6 IL5 IL4 IL17A
17
Show member pathways
12.79 TNF TLR4 IL6 IL5 IL4R IL4
18 12.77 TNF TLR3 IL4 IL17A IL10 IFNG
19
Show member pathways
12.71 TNF IL4R IL4 IL10 IFNG
20
Show member pathways
12.67 TNF IL6 IL17A IL10 IFNG
21
Show member pathways
12.64 IL6 IL5 IL4R IL4 IL13 IL11
22
Show member pathways
12.59 TNF TLR4 TLR3 IL6 IFNA1 CXCL8
23
Show member pathways
12.55 TNF IL6 IL5 IL4 IL17A IL13
24
Show member pathways
12.54 TNF IL6 IL10 CXCL8 CCL5 CCL3
25
Show member pathways
12.48 TNF TLR4 TLR3 IL6 IFNG CXCL8
26
Show member pathways
12.46 TNF IL6 IL4 IFNG CCL5
27
Show member pathways
12.46 TNF IL6 IL5 IL4 IL17A IL13
28 12.44 TNF TLR4 CXCL8 CCL5
29 12.43 TNF TLR4 IL6 IFNA1 CXCL8 CCL5
30 12.42 TNF TLR4 IL6 IL10 IFNG IFNA1
31
Show member pathways
12.4 TNF TLR4 TLR3 IL6 CXCL8
32
Show member pathways
12.4 TNF TLR4 IL4 IL10 IFNG
33
Show member pathways
12.38 TNF TLR4 SFTPD IL6 IL4 IL11
34
Show member pathways
12.35 TNF TLR4 TLR3 IFNG IFNA1
35 12.33 TNF TLR4 TLR3 IL6 IFNG
36 12.32 TNF IL6 IL13 IL10 CXCL8
37 12.25 TNF TLR4 IL6 IL10 CXCL8
38 12.24 TNF IL6 IL5 IL4 IL11 IL10
39 12.23 TNF TLR4 IL6 IL4 IFNG CXCL8
40 12.15 TNF TLR4 IL6 IL10 IFNG CXCL8
41
Show member pathways
12.13 TLR4 TLR3 IL5 IL13
42 12.13 TNF IL6 IL5 IL4R IL4 IL11
43
Show member pathways
12.12 TLR4 TLR3 IL6 IL4R IL4 IL17A
44 12.06 IL6 IFNG CXCL8 CCL3
45 12.04 IL6 IL5 IL4 IL13 IFNG CXCL8
46 12.03 TNF IL6 IL4R IL4 IL17A IL13
47
Show member pathways
12.02 TNF TLR4 TLR3 IL6 IL17A IL10
48
Show member pathways
12 TLR4 IL6 IL17A CXCL8
49 11.98 TNF IL5 IL4 IL17A IL13 IL10
50 11.97 TNF TLR4 IL6 IL10 CXCL8

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.89 TNF SFTPD RNASE3 IL6 IL5 IL4R
2 extracellular space GO:0005615 9.58 TNF TLR3 SFTPD RNASE3 IL6 IL5

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR4 TLR3 IL6 IL4 IL17A
2 signal transduction GO:0007165 10.25 TLR4 TLR3 RASSF6 IL6 IL5 IL4R
3 positive regulation of gene expression GO:0010628 10.13 TNF TLR4 TLR3 IL6 IL4 IL13
4 defense response to bacterium GO:0042742 10.11 TNF TLR4 TLR3 SFTPD RNASE3 IL10
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.09 TNF TLR4 CCL5 CCL3 CCL11
6 cellular response to lipopolysaccharide GO:0071222 10.07 TNF TLR4 IL6 IL10 CXCL8
7 defense response to virus GO:0051607 10.06 TLR3 IL6 IFNG IFNA1
8 chemotaxis GO:0006935 10.06 RNASE3 CXCL8 CCL5 CCL3 CCL11
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.04 TNF TLR4 TLR3 IL6
10 defense response GO:0006952 10.03 TNF TLR3 IFNA1 CXCL8
11 cellular response to tumor necrosis factor GO:0071356 10.02 CXCL8 CCL5 CCL3 CCL11
12 response to virus GO:0009615 10.02 TNF TLR3 IFNG CCL5 CCL11
13 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL5 IL10
14 defense response to Gram-positive bacterium GO:0050830 10.01 TNF RNASE3 IL6 IL17A
15 positive regulation of interleukin-6 production GO:0032755 10 TNF TLR4 TLR3 IL6 IL17A IFNG
16 defense response to Gram-negative bacterium GO:0050829 9.99 TLR4 RNASE3 IL6 IL17A
17 neutrophil chemotaxis GO:0030593 9.99 CXCL8 CCL5 CCL3 CCL11
18 B cell differentiation GO:0030183 9.99 IL4 IL11 IL10 IFNA1
19 cellular response to interferon-gamma GO:0071346 9.99 TLR4 TLR3 CCL5 CCL3 CCL11
20 positive regulation of tumor necrosis factor production GO:0032760 9.99 TLR4 TLR3 IL6 IL17A IFNG CCL3
21 regulation of insulin secretion GO:0050796 9.98 TNF IL6 IFNG CCL5
22 chemokine-mediated signaling pathway GO:0070098 9.98 CXCL8 CCL5 CCL3 CCL11
23 positive regulation of inflammatory response GO:0050729 9.98 TNF TLR4 TLR3 IFNG CCL3
24 cellular response to interleukin-1 GO:0071347 9.97 IL17A CXCL8 CCL5 CCL3 CCL11
25 positive regulation of smooth muscle cell proliferation GO:0048661 9.96 TNF IL6 IL13 CCL5
26 positive regulation of interleukin-8 production GO:0032757 9.96 TNF TLR4 TLR3 IL6
27 cellular response to mechanical stimulus GO:0071260 9.95 TLR4 TLR3 IL13
28 humoral immune response GO:0006959 9.95 TNF IL6 IFNG IFNA1
29 positive regulation of cytokine production GO:0001819 9.95 TNF TLR3 IL10 IFNG
30 negative regulation of tumor necrosis factor production GO:0032720 9.94 TLR4 IL4 IL10
31 negative regulation of interleukin-6 production GO:0032715 9.94 TNF TLR4 IL10
32 apoptotic signaling pathway GO:0097190 9.94 TNF TLR4 TLR3
33 cellular response to organic cyclic compound GO:0071407 9.94 TNF CCL5 CCL3
34 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.94 TNF TLR4 TLR3
35 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
36 monocyte chemotaxis GO:0002548 9.94 IL6 CCL5 CCL3 CCL11
37 positive regulation of interferon-gamma production GO:0032729 9.93 TNF TLR4 TLR3
38 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.93 TNF TLR4 TLR3
39 positive regulation of T cell proliferation GO:0042102 9.93 IL6 IL4 CCL5
40 positive regulation of interleukin-12 production GO:0032735 9.93 TLR4 TLR3 IL17A IFNG
41 positive regulation of B cell proliferation GO:0030890 9.92 TLR4 IL5 IL4 IL13
42 positive regulation of phagocytosis GO:0050766 9.91 TNF SFTPD IFNG
43 toll-like receptor signaling pathway GO:0002224 9.91 TLR4 TLR3 SFTPD
44 positive regulation of interleukin-10 production GO:0032733 9.91 TLR4 IL6 IL4 IL13
45 negative regulation of endothelial cell apoptotic process GO:2000352 9.91 IL4 IL13 IL11 IL10
46 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4 IL13 IFNG CCL5
47 extrinsic apoptotic signaling pathway GO:0097191 9.9 TNF TLR3 IFNG
48 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF TLR4 IFNG
49 protein kinase B signaling GO:0043491 9.9 TNF CCL5 CCL3
50 lymphocyte chemotaxis GO:0048247 9.9 CCL5 CCL3 CCL11

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.55 IL6 IL5 IL4 IL11 IL10
2 CCR chemokine receptor binding GO:0048020 9.5 CCL5 CCL3 CCL11
3 cytokine activity GO:0005125 9.47 TNF IL6 IL5 IL4 IL17A IL13
4 CCR5 chemokine receptor binding GO:0031730 9.43 CCL5 CCL3
5 cytokine receptor binding GO:0005126 9.43 IL4 IL13 IFNA1
6 phospholipase activator activity GO:0016004 9.4 CCL5 CCL3
7 CCR1 chemokine receptor binding GO:0031726 9.37 CCL5 CCL3
8 chemokine activity GO:0008009 9.26 CXCL8 CCL5 CCL3 CCL11

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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