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MCID: BRN002
MIFTS: 59

Bronchiolitis

Categories: Respiratory diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bronchiolitis

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MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 54 6 3 43 15 71

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2942
MeSH 43 D001988
NCIt 49 C39658
SNOMED-CT 67 4120002
UMLS 71 C0006271
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Summaries for Bronchiolitis

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CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and bronchiectasis, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 74 Bronchiolitis is blockage of the small airways in the lungs due to a viral infection. It usually only... more...

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Related Diseases for Bronchiolitis

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Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 878)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 34.4 TNF TLR4 IL6 IL17A IL13 IL10
2 bronchiectasis 32.8 TNF TLR2 IL6 CXCL8
3 bronchopneumonia 32.8 TNF TLR4 IL6 IL10 CXCL8
4 idiopathic interstitial pneumonia 32.6 IL4R IL4 IL13 IFNG CXCL8
5 extrinsic allergic alveolitis 32.6 IL6 IL10 CXCL8 CCL5 CCL3
6 chronic graft versus host disease 31.7 IL10 IFNG
7 graft-versus-host disease 31.7 TNF IL6 IL10 IFNG
8 bronchitis 31.4 TNF TLR4 TLR2 RNASE3 IL6 IL5
9 cytokine deficiency 31.4 IL5 IL13
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 IL17A IL10 IFNG
11 haemophilus influenzae 31.0 TNF TLR2 CXCL8
12 acute graft versus host disease 31.0 TNF IL4 IL10 IFNG
13 exanthem 30.9 TNF IL6 IL10 CXCL8
14 vascular disease 30.9 TNF TLR4 IL6 IL10 IFNG
15 ige responsiveness, atopic 30.9 RNASE3 IL5 IL4R IL4 IL13 IL10
16 pulmonary edema 30.8 TNF IL13 IL10 CXCL8
17 respiratory failure 30.7 TNF RNASE3 MUC5AC IL6 IL5 IL13
18 cytomegalovirus infection 30.6 TNF IL6 CXCL8 CCL5 CCL3
19 mycobacterium kansasii 30.6 TLR2 CXCL8
20 gastroesophageal reflux 30.6 TNF IL6 IL5 IL4 CXCL8 CCL11
21 acute cystitis 30.6 TNF TLR4 TLR2 IL6 IL10 CXCL8
22 erythema multiforme 30.6 TNF IL6 IL5 IL4 IFNG CXCL8
23 lymphopenia 30.6 IL6 IL4 IL10 IFNG
24 lung abscess 30.6 TNF IL6 IFNG
25 combined t cell and b cell immunodeficiency 30.6 IL6 IL4 IL10
26 systemic scleroderma 30.6 TNF IL6 IL4 IL17A IFNG
27 juvenile rheumatoid arthritis 30.6 TNF IL6 IL10 IFNG CXCL8
28 eosinophilic pneumonia 30.5 RNASE3 IL5 IL4 IL13 CXCL8 CCL5
29 pertussis 30.5 TNF TLR4 IL6 IL10 CXCL8 CCL5
30 cystic fibrosis 30.5 TNF TLR4 RNASE3 MUC5AC IL6 IL17A
31 interstitial lung disease 30.5 TNF IL6 IL5 IL4 IL17A IL13
32 thymoma 30.5 TNF IL6 IL4 IL17A
33 mycobacterium abscessus 30.5 TNF TLR2 CXCL8
34 thyroiditis 30.5 TNF IL6 IL4 IL10
35 cryoglobulinemia 30.4 TNF IL6 IL10 IFNG
36 stevens-johnson syndrome/toxic epidermal necrolysis 30.4 IL5 IL13 IFNG CCL5
37 mixed connective tissue disease 30.4 TNF IL6 IL10 IFNG
38 sudden infant death syndrome 30.4 TNF IL6 IL13 IL10 CXCL8
39 adult respiratory distress syndrome 30.4 TNF IL6 IL10 CXCL8
40 spondylitis 30.4 TNF IL6 IL17A IL10 IFNG
41 coronary artery anomaly 30.4 TNF IL6 IL10 CXCL8
42 hypereosinophilic syndrome 30.4 RNASE3 IL5 IL4 IL13 IL10 IFNG
43 cryptococcosis 30.4 TNF IL4 IL17A IL13 IL10 IFNG
44 neurofibromatosis, type ii 30.4 TNF TLR2 IL6 CXCL8
45 pustulosis of palm and sole 30.4 TNF IL17A CXCL8
46 connective tissue disease 30.4 TNF TLR4 TLR2 IL6 IL4 IL17A
47 bacteriuria 30.4 TLR4 TLR2 IL6 CXCL8
48 sarcoidosis 1 30.4 TNF IL13 IFNG CCL5 CCL3
49 crohn's colitis 30.4 TNF IFNG CXCL8
50 post-transplant lymphoproliferative disease 30.4 TNF IL6 IL10

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis
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Symptoms & Phenotypes for Bronchiolitis

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Symptoms:

12
  • • fever
  • • cough
  • • wheezing
  • • shortness of breath
  • • nasal flaring in infants
  • • bluish skin due to lack of oxygen

MGI Mouse Phenotypes related to Bronchiolitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.31 CCL11 CCL5 IFNG IL10 IL13 IL17A
2 immune system MP:0005387 10.27 CCL11 CCL5 IFNG IL10 IL13 IL17A
3 digestive/alimentary MP:0005381 10.26 IFNG IL10 IL13 IL17A IL4 IL4R
4 homeostasis/metabolism MP:0005376 10.25 IFNG IL10 IL13 IL17A IL4 IL4R
5 endocrine/exocrine gland MP:0005379 10.16 IFNG IL10 IL13 IL17A IL4 IL4R
6 integument MP:0010771 10.02 IFNG IL10 IL13 IL17A IL4 IL4R
7 liver/biliary system MP:0005370 9.91 IFNG IL10 IL4 IL4R IL5 IL6
8 muscle MP:0005369 9.76 IFNG IL10 IL13 IL6 TLR2 TLR3
9 neoplasm MP:0002006 9.56 IFNG IL10 IL5 IL6 TLR2 TLR3
10 respiratory system MP:0005388 9.44 CCL11 IFNG IL10 IL13 IL17A IL4
Sources

Drugs & Therapeutics for Bronchiolitis

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Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 220)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromhexine Approved Phase 4 3572-43-8
2
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
4
Clarithromycin Approved Phase 4 81103-11-9 84029
5
Montelukast Approved Phase 4 158966-92-8 5281040
6
Aztreonam Approved Phase 4 78110-38-0 5362041 5742832
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
9
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
10
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
11
Sotalol Approved Phase 4 959-24-0, 3930-20-9 5253
12
Macitentan Approved Phase 4 441798-33-0
13
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4, 22737-96-8 445354 9904001
14
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
15
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
16 Anti-Infective Agents Phase 4
17 Erythromycin Ethylsuccinate Phase 4
18 Erythromycin Estolate Phase 4
19 Erythromycin stearate Phase 4
20 Anti-Bacterial Agents Phase 4
21 Cytochrome P-450 CYP3A Inhibitors Phase 4
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Leukotriene Antagonists Phase 4
24 Nutrients Phase 4
25 Micronutrients Phase 4
26 Trace Elements Phase 4
27 Cysteinyl-leukotriene Phase 4
28 Antitubercular Agents Phase 4
29 lysine Phase 4
30 retinol Phase 4
31 Retinol palmitate Phase 4
32 Amoxicillin-Potassium Clavulanate Combination Phase 4
33 beta-Lactamase Inhibitors Phase 4
34 Albuterol Phase 4
35 Tiotropium Bromide Phase 4 136310-93-5
36 Cholinergic Agents Phase 4
37 Bromides Phase 4
38 Parasympatholytics Phase 4
39 Cholinergic Antagonists Phase 4
40 Expectorants Phase 4
41 Antiviral Agents Phase 4
42 Anti-Arrhythmia Agents Phase 4
43 Anticonvulsants Phase 4
44 N-monoacetylcystine Phase 4
45 Antidotes Phase 4
46 Adrenergic Antagonists Phase 4
47 Adrenergic beta-Antagonists Phase 4
48 Sodium Channel Blockers Phase 4
49 Diuretics, Potassium Sparing Phase 4
50 Sympatholytics Phase 4

Interventional clinical trials:

(show top 50) (show all 429)
# Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis Unknown status NCT01216553 Phase 4
2 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
3 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
4 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
5 Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans Completed NCT00367419 Phase 4 Erythromycin
6 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
7 A Randomized, Double Blind, Placebo Controlled Trial With Montelukast to Treat Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01211509 Phase 4 Montelukast
8 A Randomized Double Blind Placebo Controlled Trial With Vitamin D to Prevent Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01212406 Phase 4 Vitamin D
9 Nebulized Hypertonic Saline for Acute Bronchiolitis in the Emergency Department Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
10 Effects of Reduction of the Length of Treatment by Nebulized 3% Hypertonic Saline From 72 to 24 Hours on Clinical Remission, in Children Younger Than 12 Month Hospitalized for Acute Bronchiolitis. BRONDUSAL Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
11 A Prospective, Open-label Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
12 Randomized Double-blind Placebo-controlled Prevention Trial of Azithromycin in Lung Transplantation. Completed NCT01009619 Phase 4 Azithromycin;Placebo
13 Acute Bronchodilator Responsiveness in Obliterative Bronchiolitis (OB) Following Hematopoietic Stem Cell Transplantation Completed NCT01112241 Phase 4 albuterol plus tiotropium
14 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis: A Multicenter Randomized Controlled Trial Completed NCT00119002 Phase 4 dexamethasone;Placebo
15 Impact of the Administration of Systemic Glucocorticoids on Inflammatory Response and Clinical Evolution of Patients Diagnosed With Moderate- Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
16 Impact of Oximetry on Hospitalization Completed NCT00673946 Phase 4
17 7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
18 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
19 Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
20 Pilot Study: Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
21 A Randomized Trial of Nebulized 3% Hypertonic Saline With Salbutamol in the Treatment of Acute Bronchiolitis in Pediatric Hospital Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
22 Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
23 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
24 Phase 4 Study of Oral Montelukast Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
25 Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy Completed NCT00402805 Phase 4
26 Small Airways Evaluation and Peripherical Effect of Two Bronchodilators in Healthy Subjects and Stable COPD Patients Completed NCT01437748 Phase 4 Indacaterol maleate;Tiotropium bromide
27 Impact of Vitamin D Supplementation on Recurrent Respiratory Infections in Paediatric Completed NCT02617771 Phase 4 Vitamin D3
28 A Randomized Double-blind Trial Comparing the Effect on Pain of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Nasopharyngeal Aspiration Completed NCT01544946 Phase 4 88% sucrose po;placebo po
29 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
30 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
31 Randomized Controlled Trial to Compare the Efficacy of High Flow Nasal Cannula Oxygen Therapy vs Low Flow Oxygen Therapy in Bronchiolitis Recruiting NCT03015051 Phase 4 Oxygen
32 Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial Recruiting NCT03364218 Phase 4 N-Acetyl Cysteine
33 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
34 Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing - the INSTAR Study Recruiting NCT03889743 Phase 4 Dexamethasone treatment during 3 days;placebo treatment during 3 days
35 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Recruiting NCT02347111 Phase 4 Flecainide;Sotalol
36 A Prospective Study on the Use of Hypertonic Saline Inhalation in Acute Bronchiolitis in Children Not yet recruiting NCT03880903 Phase 4 normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
37 Potential Therapy With MACITENTAN in the Treatment of Chronic Lung Allograft Dysfunction (CLAD) After Lung Transplantation Not yet recruiting NCT02893176 Phase 4 macitentan;placebo (for macitentan)
38 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
39 Effectiveness of Inhaled Corticosteroids in Preschool Children Following Hospital Admission for Acute Dyspnea and Wheeze Terminated NCT00962299 Phase 4 Beclomethasone;Placebo
40 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
41 Nebulized Budesonide After Discharge From a Pediatric Emergency Department in Preventing Asthma Relapse: A Randomized, Double-Blind, Placebo Controlled Trial. Withdrawn NCT00584636 Phase 4 pulmicort respules
42 IMLEMENTATION OF High Flow Nasal Cannulae Therapy FOR THE TREATMENT OF BRONCHIOLITIS IN A GENERAL PEDIATRIC WARD - A RETROSPECTIVE AND PROSPECTIVE CLINICAL TRIAL Unknown status NCT02366715 Phase 3
43 Comparison Between 2l/Min/kg vs 3l/Min/kg in High Flow Nasal Cannula (HFNC) During the Initial Management of Severe Bronchiolitis in Infants Unknown status NCT02824744 Phase 3
44 Open Trial With Randomized Withdrawal of Treatment, to Evaluate the Efficacy of Azithromycin in the Treatment of Children With Non Cystic Fibrosis Bronchiectasis ( AZI-STOP Study ) Unknown status NCT02531984 Phase 3 Azithromycin
45 Phase III, Randomized, Double Blind Study of Low Dose Long Term Clarithromycin Versus Placebo in Treatment of Chronic Pulmonary Lesions Due to Sulfur Mustard Completed NCT00381147 Phase 3 Clarithromycin
46 Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
47 Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients: a Double-Blind Randomized Study Completed NCT00512811 Phase 3 furosemide
48 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
49 The Use of Heliox Driven Racemic Epinephrine Nebulization in the Treatment of Moderate to Severe Bronchiolitis in Pediatric Emergency Department Patients Completed NCT00116584 Phase 3 heliox
50 A Randomized, 2-Period, Multicenter, Dble-Blind, Parallel-Group Study Comparing Effects of 2 Doses of MK0476 and Placebo in the Tx of Respiratory Symptoms Associated w/ Respiratory Syncytial Virus-Induced Bronchiolitis in Children 3 to 24 Mths Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

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Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

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MalaCards organs/tissues related to Bronchiolitis:

40
Lung, Heart, Bone, T Cells, Bone Marrow, Testes, Skin
Sources

Publications for Bronchiolitis

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Articles related to Bronchiolitis:

(show top 50) (show all 10659)
# Title Authors PMID Year
1
Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. 54 61
19773677 2009
2
Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. 54 61
19005677 2009
3
[Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. 54 61
19470255 2009
4
[Relationship of levels of CD4(+)CD25(+) regulatory T cells and expression of Foxp3 mRNA in peripheral blood with serum immunoglobulin E level in children with bronchiolitis]. 54 61
19470254 2009
5
[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]. 54 61
19567118 2009
6
[Association of INF-gamma/A+874T gene polymorphisms with respiratory syncytial virus bronchiolitis]. 54 61
19149916 2009
7
[Association between interleukin-8 gene-251 locus polymorphism and respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infants]. 54 61
18282421 2007
8
Immunopathogenesis of respiratory syncytial virus bronchiolitis. 54 61
17436234 2007
9
Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. 54 61
17356094 2007
10
Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. 54 61
17297249 2007
11
[Genetic polymorphisms and infections]. 54 61
16697544 2006
12
Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. 54 61
16503988 2006
13
Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. 54 61
16192901 2005
14
Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis. 54 61
15898980 2005
15
Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. 54 61
15765744 2005
16
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. 54 61
15356575 2004
17
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. 54 61
15161635 2004
18
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. 54 61
15085176 2004
19
Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. 54 61
15144474 2004
20
Haplotype mapping of the bronchiolitis susceptibility locus near IL8. 54 61
14605870 2004
21
Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. 54 61
14722888 2004
22
Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. 54 61
12847481 2003
23
Respiratory syncytial virus and other respiratory viruses. 54 61
12671447 2003
24
Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus. 54 61
14736212 2003
25
The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis. 54 61
15366660 2003
26
Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. 54 61
12508140 2003
27
Steroids fail to down-regulate respiratory syncytial virus-induced IL-8 secretion in infants. 54 61
12193669 2002
28
RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants. 54 61
12027066 2002
29
DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. 54 61
11716180 2001
30
Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. 54 61
11431705 2001
31
Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. 54 61
11389573 2001
32
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. 54 61
10489841 1999
33
Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. 54 61
10351940 1999
34
Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma? 54 61
9920219 1998
35
Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing. 54 61
9261851 1997
36
Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis. 54 61
9220520 1997
37
Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. 54 61
9041319 1997
38
Persistence of respiratory syncytial virus (RSV) infection and development of RSV-specific IgG1 response in a guinea-pig model of acute bronchiolitis. 54 61
9032486 1997
39
Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis. 54 61
9151339 1996
40
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. 54 61
7841728 1994
41
Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease. 54 61
8087190 1994
42
Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus. 54 61
8087188 1994
43
Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. 54 61
1731020 1992
44
Small Airway Disease: A Step Closer to Etiology-Based Classification of Bronchiolitis. 61
32005432 2020
45
Instrucciones de Alta por Video: Effectiveness of Video Discharge Instructions for Spanish-Speaking Caregivers in the Pediatric Emergency Department. 61
32019682 2020
46
Neutrophil-endothelial interactions in respiratory syncytial virus bronchiolitis: An understudied aspect with a potential for prediction of severity of disease. 61
31931445 2020
47
Reflux-Aspiration in Chronic Lung Disease. 61
31697575 2020
48
Impact of the Choosing Wisely® Campaign Recommendations for Hospitalized Children on Clinical Practice: Trends from 2008 to 2017. 61
31532743 2020
49
Successful bilateral lung transplantation and simultaneous Nuss technique correction of pectus excavatum post-allogeneic haematopoietic stem cell transplantation. 61
31596480 2020
50
Implementation of an organizational infrastructure paediatric plan adapted to bronchiolitis epidemics. 61
31378693 2020
Sources

Variations for Bronchiolitis

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ClinVar genetic disease variations for Bronchiolitis:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;t(2;3)(q34;p23)Translocation Likely pathogenic 267915
2 46;XY;t(16;20)(q23.1;p11.22)Translocation Uncertain significance 267924
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Expression for Bronchiolitis

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Search GEO for disease gene expression data for Bronchiolitis.
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Pathways for Bronchiolitis

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Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 14.12 TNF TLR7 TLR4 TLR3 TLR2 RNASE3
2
ERK Signaling 63
Show member pathways
 13.96 TNF IL6 IL5 IL4R IL4 IL17A
3
PEDF Induced Signaling 63
Show member pathways
 13.82 TNF TLR4 IL6 IL5 IL4R IL4
4
TGF-Beta Pathway 63
Show member pathways
 13.71 TNF IL6 IL5 IL4R IL4 IL17A
5
Cytokine Signaling in Immune system 65
Show member pathways
 13.51 TNF IL6 IL5 IL4R IL4 IL17A
6
PAK Pathway 63
Show member pathways
 13.47 TNF IL6 IL5 IL4R IL4 IL17A
7
IL-2 Pathway 63
Show member pathways
 13.33 TNF TLR7 TLR4 TLR3 TLR2 IL4R
8
Toll-like Receptor Signaling Pathway 1 36
Show member pathways
 13.3 TNF TLR7 TLR4 TLR3 TLR2 IL6
9
PI3K-Akt signaling pathway 36
Show member pathways
 13.11 TNF TLR4 TLR3 TLR2 IL6 IL4R
10
Human cytomegalovirus infection 36
Show member pathways
 13.1 TNF TLR4 TLR3 TLR2 IL6 CXCL8
11
Allograft rejection 1 36
Show member pathways
 13.05 TNF RNASE3 IL6 IL5 IL4 IL17A
12
Measles 36
Show member pathways
 13.02 TNF TLR7 TLR4 TLR3 TLR2 IL6
13
Pathways in cancer 36
12.99 IL6 IL5 IL4R IL4 IL13 IFNG
14
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways 65
Show member pathways
 12.93 TNF TLR4 TLR3 IL6 IFNG CXCL8
15
Herpes simplex virus 1 infection 36
12.91 TNF TLR3 TLR2 IL6 IFNG CCL5
16
NF-KappaB Family Pathway 63
Show member pathways
 12.83 TNF TLR7 TLR4 TLR3 TLR2 IL6
17
T cell receptor signaling pathway 36
Show member pathways
 12.81 TNF TLR4 TLR2 IL6 IL5 IL4
18
NF-kappaB Signaling 4
12.77 TNF TLR7 TLR3 TLR2 IL4 IL17A
19
Th17 cell differentiation 36
Show member pathways
 12.77 TNF TLR4 TLR2 IL6 IL5 IL4R
20
Immune response NFAT in immune response 22
Show member pathways
 12.71 TNF IL4R IL4 IL10 IFNG
21
Immune response IL-23 signaling pathway 22
Show member pathways
 12.68 TNF IL6 IL17A IL10 IFNG
22
TRAF Pathway 63
Show member pathways
 12.68 TNF TLR7 TLR4 TLR3 TLR2
23
Akt Signaling 63
Show member pathways
 12.67 TNF TLR7 TLR4 TLR3 TLR2 IL6
24
JAK-STAT signaling pathway (KEGG) 36
Show member pathways
 12.56 IL6 IL5 IL4R IL4 IL13 IL10
25
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.54 TNF IL6 IL10 CXCL8 CCL5 CCL3
26
Toll Comparative Pathway 63
Show member pathways
 12.49 TNF TLR4 TLR3 IL6 IFNG CXCL8
27
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.49 TNF TLR7 TLR4 TLR3 TLR2 IL6
28
Folate Metabolism 1
Show member pathways
 12.47 TNF IL6 IL4 IFNG CCL5
29
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.47 TNF IL6 IL5 IL4 IL17A IL13
30
Toxoplasmosis 36
Show member pathways
 12.45 TNF TLR4 TLR2 IL4 IL10 IFNG
31
Shigellosis 36
12.43 TNF TLR4 CXCL8 CCL5
32
Tuberculosis 36
12.43 TNF TLR4 TLR2 IL6 IL10 IFNG
33
Colorectal Cancer Metastasis 63
12.4 TNF TLR7 TLR4 TLR3 TLR2 IL6
34
Bacterial infections in CF airways 22
Show member pathways
 12.39 TNF TLR7 TLR4 TLR2 IL6 IL4
35
NOD-like receptor signaling pathway 36
12.38 TNF TLR4 IL6 CXCL8 CCL5
36
IL-1 Family Signaling Pathways 64
Show member pathways
 12.37 TNF TLR2 MUC5AC IL6 CXCL8
37
Pathogenic Escherichia coli infection 36
12.36 TNF TLR4 IL6 CXCL8
38
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.33 TNF IL6 IL13 IL10 CXCL8
39
Necroptosis 36
Show member pathways
 12.29 TNF TLR4 TLR3 IFNG
40
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 12.26 TNF TLR4 TLR2 IL6 IL4 IL13
41
MAPK Pathway 70
Show member pathways
 12.25 TLR7 TLR4 TLR3 TLR2 IL5 IL13
42
Spinal Cord Injury 1
12.23 TNF TLR4 IL6 IL4 IFNG CXCL8
43
Th1 Differentiation Pathway 64
Show member pathways
 12.22 TNF TLR7 TLR4 TLR3 TLR2 IL6
44
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
12.21 TNF IL6 IL5 IL4 IL10 IFNG
45
Yersinia infection 36
12.19 TNF TLR4 IL6 IL10 CXCL8
46
Amoebiasis 36
12.14 TNF TLR4 TLR2 IL6 IL10 IFNG
47
Interleukin-4 and 13 signaling 65
12.11 TNF IL6 IL4R IL4 IL17A IL13
48
Hematopoietic cell lineage 36
12.1 TNF IL6 IL5 IL4R IL4
49
Senescence and Autophagy in Cancer 1
12.07 IL6 IFNG CXCL8 CCL3
50
Glucocorticoid receptor regulatory network 1
12.04 IL6 IL5 IL4 IL13 IFNG CXCL8
Sources

GO Terms for Bronchiolitis

About this section

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF RNASE3 MUC5AC IL6 IL5 IL4R
2 extracellular space GO:0005615 9.53 TNF TLR3 RNASE3 MUC5AC IL6 IL5

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.31 TNF TLR4 TLR3 TLR2 IL6 IL4
2 signal transduction GO:0007165 10.25 TLR7 TLR4 TLR3 TLR2 RASSF6 IL6
3 positive regulation of gene expression GO:0010628 10.13 TNF TLR4 TLR3 TLR2 IL6 IL4
4 defense response to bacterium GO:0042742 10.11 TNF TLR4 TLR3 RNASE3 IL10
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.08 TNF TLR4 CCL5 CCL3 CCL11
6 cellular response to lipopolysaccharide GO:0071222 10.07 TNF TLR4 IL6 IL10 CXCL8
7 defense response to virus GO:0051607 10.06 TLR7 TLR3 IL6 IFNG
8 response to lipopolysaccharide GO:0032496 10.05 TLR4 TLR2 IL13 IL10
9 chemotaxis GO:0006935 10.05 CXCL8 CCL5 CCL3 CCL11
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.04 TNF TLR4 TLR3 TLR2 IL6
11 cellular response to tumor necrosis factor GO:0071356 10.03 CXCL8 CCL5 CCL3 CCL11
12 cellular response to interferon-gamma GO:0071346 10.02 TLR4 TLR3 TLR2 CCL5 CCL3 CCL11
13 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL5 IL10
14 defense response to Gram-positive bacterium GO:0050830 10.01 TNF TLR2 RNASE3 IL6
15 response to virus GO:0009615 10.01 TNF TLR3 IFNG CCL5 CCL11
16 cellular response to interleukin-1 GO:0071347 10 IL17A CXCL8 CCL5 CCL3 CCL11
17 positive regulation of inflammatory response GO:0050729 9.99 TNF TLR7 TLR4 TLR3 TLR2 CCL3
18 neutrophil chemotaxis GO:0030593 9.98 CXCL8 CCL5 CCL3 CCL11
19 cellular response to mechanical stimulus GO:0071260 9.98 TLR7 TLR4 TLR3 IL13
20 chemokine-mediated signaling pathway GO:0070098 9.97 CXCL8 CCL5 CCL3 CCL11
21 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.97 TNF TLR7 TLR4 TLR3 TLR2
22 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.96 TNF TLR7 TLR4 TLR3
23 positive regulation of smooth muscle cell proliferation GO:0048661 9.96 TNF IL6 IL13 CCL5
24 cellular response to organic cyclic compound GO:0071407 9.94 TNF CCL5 CCL3
25 regulation of insulin secretion GO:0050796 9.94 TNF IFNG CCL5
26 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
27 apoptotic signaling pathway GO:0097190 9.94 TNF TLR4 TLR3
28 positive regulation of tumor necrosis factor production GO:0032760 9.94 TLR4 TLR3 TLR2 CCL3
29 positive regulation of T cell proliferation GO:0042102 9.93 IL6 IL4 CCL5
30 humoral immune response GO:0006959 9.93 TNF IL6 IFNG
31 monocyte chemotaxis GO:0002548 9.93 IL6 CCL5 CCL3 CCL11
32 toll-like receptor signaling pathway GO:0002224 9.93 TLR7 TLR4 TLR3 TLR2
33 cytokine-mediated signaling pathway GO:0019221 9.93 TNF IL6 IL5 IL4R IL4 IL17A
34 extrinsic apoptotic signaling pathway GO:0097191 9.92 TNF TLR3 IFNG
35 positive regulation of B cell proliferation GO:0030890 9.92 TLR4 IL5 IL4 IL13
36 lipopolysaccharide-mediated signaling pathway GO:0031663 9.92 TNF TLR4 TLR2 CCL5 CCL3
37 positive regulation of nitric oxide biosynthetic process GO:0045429 9.91 TNF TLR4 IFNG
38 protein kinase B signaling GO:0043491 9.91 TNF CCL5 CCL3
39 positive regulation of interleukin-6 secretion GO:2000778 9.91 TNF TLR4 TLR2 IL17A
40 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.91 TNF IL6 IL4 IL13 IFNG CCL5
41 negative regulation of endothelial cell apoptotic process GO:2000352 9.9 IL4 IL13 IL10
42 negative regulation of interleukin-6 production GO:0032715 9.9 TNF TLR4 IL10
43 lymphocyte chemotaxis GO:0048247 9.9 CCL5 CCL3 CCL11
44 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.89 TLR7 TLR4 TLR2
45 negative regulation of neurogenesis GO:0050768 9.89 TNF IL6 CCL11
46 positive regulation of interleukin-12 production GO:0032735 9.89 TLR4 TLR3 TLR2 IFNG
47 positive regulation of JAK-STAT cascade GO:0046427 9.89 TNF IL6 IL5 IL10 CCL5
48 positive regulation of interferon-beta production GO:0032728 9.88 TLR4 TLR3 TLR2
49 negative regulation of osteoclast differentiation GO:0045671 9.88 TLR4 TLR3 IL4 CCL3
50 positive regulation of macrophage activation GO:0043032 9.87 TLR4 IL4R IL13 IL10

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.13 TNF TLR7 TLR4 TLR3 TLR2 RASSF6
2 growth factor activity GO:0008083 9.73 IL6 IL5 IL4 IL10
3 lipopolysaccharide binding GO:0001530 9.5 TLR4 TLR2 RNASE3
4 signaling pattern recognition receptor activity GO:0008329 9.49 TLR7 TLR2
5 phospholipase activator activity GO:0016004 9.48 CCL5 CCL3
6 CCR5 chemokine receptor binding GO:0031730 9.46 CCL5 CCL3
7 CCR chemokine receptor binding GO:0048020 9.43 CCL5 CCL3 CCL11
8 CCR1 chemokine receptor binding GO:0031726 9.4 CCL5 CCL3
9 cytokine activity GO:0005125 9.4 TNF IL6 IL5 IL4 IL17A IL13
10 lipopolysaccharide receptor activity GO:0001875 9.37 TLR4 TLR2
11 chemokine activity GO:0008009 9.26 CXCL8 CCL5 CCL3 CCL11
Sources

Sources for Bronchiolitis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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