Bronchiolitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BRN002 MIFTS: 59	Bronchiolitis Categories: Respiratory diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis ¹² ⁵⁴ ⁶ ³ ⁴³ ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Respiratory diseases Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2942

MeSH ⁴³ D001988

NCIt ⁴⁹ C39658

SNOMED-CT ⁶⁷ 4120002

UMLS ⁷¹ C0006271

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Summaries for Bronchiolitis

CDC : ³ Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and bronchopneumonia, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Macitentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : ¹² A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : ⁷⁴ Bronchiolitis is blockage of the small airways in the lungs due to a viral infection. It usually only... more...

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Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 904)

#	Related Disease	Score	Top Affiliating Genes
1	bronchiolitis obliterans	34.5	TNF TLR4 IL6 IL17A IL13 IL10
2	bronchopneumonia	32.9	TNF TLR4 IL6 IL10 CXCL8
3	extrinsic allergic alveolitis	32.6	IL6 IL10 CXCL8 CCL5 CCL3
4	idiopathic interstitial pneumonia	32.6	IL4R IL4 IL13 IFNG CXCL8
5	bronchitis	31.8	TNF TLR4 RNASE3 IL6 IL5 IL4
6	graft-versus-host disease	31.7	TNF IL6 IL10 IFNG
7	chronic graft versus host disease	31.7	IL10 IFNG
8	cytokine deficiency	31.4	IL5 IL13
9	pemphigus	31.3	TNF IL6 IL4 IL10
10	haemophilus influenzae	31.1	TNF CXCL8
11	alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity	31.1	IL17A IL10 IFNG
12	acute graft versus host disease	31.0	TNF IL4 IL10 IFNG
13	vasculitis	31.0	TNF IL6 IL17A IL10
14	ige responsiveness, atopic	31.0	RNASE3 IL5 IL4R IL4 IL13 IL10
15	acute cystitis	31.0	TNF TLR4 IL6 IL10 CXCL8
16	connective tissue disease	31.0	TNF IL6 IL4 IL17A IL10 IFNG
17	vascular disease	30.9	TNF TLR4 IL6 IL10 IFNG
18	exanthem	30.9	TNF IL6 IL10 IFNG CXCL8
19	histiocytosis	30.8	TNF IL17A IFNG
20	pulmonary edema	30.8	TNF IL13 IL10 CXCL8
21	gastroesophageal reflux	30.7	TNF IL6 IL5 IL4 CXCL8 CCL11
22	cytomegalovirus infection	30.7	TNF IL6 CXCL8 CCL5 CCL3
23	bacteriuria	30.6	TLR4 IL6 CXCL8
24	erythema multiforme	30.6	TNF IL6 IL5 IL4 IL13 IFNG
25	lymphopenia	30.6	IL6 IL4 IL10 IFNG
26	juvenile arthritis	30.6	IL6 IL10 CXCL8
27	respiratory failure	30.6	TNF TLR4 RNASE3 MUC5AC IL6 IL5
28	lung abscess	30.6	TNF IL6 IFNG
29	juvenile rheumatoid arthritis	30.6	TNF IL6 IL10 IFNG CXCL8
30	interstitial lung disease	30.6	TNF IL6 IL5 IL4 IL17A IL13
31	bronchial disease	30.6	TNF TLR7 TLR4 TLR3 RNASE3 MUC5AC
32	cystic fibrosis	30.5	TNF TLR4 RNASE3 MUC5AC IL6 IL17A
33	pertussis	30.5	TNF TLR4 IL6 IL10 CXCL8 CCL5
34	hypereosinophilic syndrome	30.5	RNASE3 IL5 IL4 IL13 IL10 IFNG
35	stevens-johnson syndrome/toxic epidermal necrolysis	30.5	IL5 IL13 IFNG CCL5
36	granulomatosis with polyangiitis	30.5	TNF TLR4 IL5 IL17A
37	sudden infant death syndrome	30.5	TNF IL6 IL13 IL10 CXCL8
38	thyroiditis	30.5	TNF IL6 IL4 IL10
39	cryoglobulinemia	30.5	TNF IL6 IL10 IFNG
40	mixed connective tissue disease	30.5	TNF IL6 IL10 IFNG
41	spondylitis	30.5	TNF IL6 IL17A IL10 IFNG
42	adult respiratory distress syndrome	30.4	TNF IL6 IL10 CXCL8
43	cryptococcosis	30.4	TNF IL4 IL17A IL13 IL10 IFNG
44	thymoma	30.4	TNF IL6 IL4 IL17A
45	pustulosis of palm and sole	30.4	TNF IL17A CXCL8
46	crohn's colitis	30.4	TNF IFNG CXCL8
47	eosinophilic fasciitis	30.4	IL5 IFNG
48	eosinophilic pneumonia	30.4	RNASE3 IL6 IL5 IL4 IL13 CXCL8
49	peptic esophagitis	30.4	TNF IL6 CXCL8
50	post-transplant lymphoproliferative disease	30.4	TNF IL6 IL10

Graphical network of the top 20 diseases related to Bronchiolitis:

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Symptoms & Phenotypes for Bronchiolitis

Symptoms:

¹²

• fever
• cough
• wheezing

• shortness of breath
• nasal flaring in infants
• bluish skin due to lack of oxygen

MGI Mouse Phenotypes related to Bronchiolitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	10.25	CCL11 CCL5 IFNG IL10 IL13 IL17A
2	immune system	MP:0005387	10.2	CCL11 CCL5 IFNG IL10 IL13 IL17A
3	homeostasis/metabolism	MP:0005376	10.18	IFNG IL10 IL13 IL17A IL4 IL4R
4	digestive/alimentary	MP:0005381	10.17	IFNG IL10 IL13 IL17A IL4 IL4R
5	integument	MP:0010771	9.91	IFNG IL10 IL13 IL17A IL4 IL4R
6	liver/biliary system	MP:0005370	9.76	IFNG IL10 IL4 IL4R IL5 IL6
7	neoplasm	MP:0002006	9.5	IFNG IL10 IL5 IL6 TLR3 TLR4
8	respiratory system	MP:0005388	9.4	CCL11 IFNG IL10 IL13 IL17A IL4

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Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 214)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bromhexine

Approved

Phase 4

3572-43-8

Macitentan

Approved

Phase 4

441798-33-0

Erythromycin

Approved, Investigational, Vet_approved

Phase 4

114-07-8

12560 441411

Mechlorethamine

Approved, Investigational

Phase 4

51-75-2

4033

Clarithromycin

Approved

Phase 4

81103-11-9

84029

Montelukast

Approved

Phase 4

158966-92-8

5281040

Aztreonam

Approved

Phase 4

78110-38-0

5742832 5362041

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Ceftriaxone

Approved

Phase 4

73384-59-5

5361919 5479530

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

12035

Sotalol

Approved

Phase 4

3930-20-9, 959-24-0

5253

Vitamin A

Approved, Nutraceutical, Vet_approved

Phase 4

22737-96-8, 68-26-8, 11103-57-4

9904001 445354

Cysteine

Approved, Nutraceutical

Phase 4

52-90-4

5862

Maleic acid

Experimental, Investigational

Phase 4

110-17-8, 110-16-7

444972

Endothelin A Receptor Antagonists

Phase 4

Endothelin Receptor Antagonists

Phase 4

Erythromycin Estolate

Phase 4

Erythromycin stearate

Phase 4

Erythromycin Ethylsuccinate

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Leukotriene Antagonists

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

lysine

Phase 4

Retinol palmitate

Phase 4

retinol

Phase 4

Amoxicillin-Potassium Clavulanate Combination

Phase 4

beta-Lactamase Inhibitors

Phase 4

Protective Agents

Phase 4

Antiviral Agents

Phase 4

Antioxidants

Phase 4

Antidotes

Phase 4

Expectorants

Phase 4

N-monoacetylcystine

Phase 4

Albuterol

Phase 4

Parasympatholytics

Phase 4

Cholinergic Agents

Phase 4

Cholinergic Antagonists

Phase 4

Tiotropium Bromide

Phase 4

136310-93-5

Bromides

Phase 4

Anticonvulsants

Phase 4

Anti-Arrhythmia Agents

Phase 4

Sodium Channel Blockers

Phase 4

Adrenergic Antagonists

Phase 4

Sympatholytics

Phase 4

Adrenergic beta-Antagonists

Phase 4

Diuretics, Potassium Sparing

Phase 4

BB 1101

Phase 4

Interventional clinical trials:

(show top 50) (show all 448)

#	Name	Status	NCT ID	Phase	Drugs
1	Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis	Unknown status	NCT01216553	Phase 4
2	Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis?	Unknown status	NCT00817466	Phase 4	Racemic adrenaline;Isotonic saline
3	Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa	Unknown status	NCT02054182	Phase 4	Vitamin D
4	Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children	Unknown status	NCT00494624	Phase 4	prednisolone
5	Potential Therapy With MACITENTAN in the Treatment of Chronic Lung Allograft Dysfunction (CLAD) After Lung Transplantation	Unknown status	NCT02893176	Phase 4	macitentan;placebo (for macitentan)
6	Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans	Completed	NCT00367419	Phase 4	Erythromycin
7	Chronic Bronchiolitis or Resistant Asthma?	Completed	NCT00368342	Phase 4	Erythromycin, Azithromycin , Clarithromycin
8	A Randomized, Double Blind, Placebo Controlled Trial With Montelukast to Treat Bronchiolitis Obliterans Syndrome After Lung Transplantation	Completed	NCT01211509	Phase 4	Montelukast
9	A Randomized Double Blind Placebo Controlled Trial With Vitamin D to Prevent Bronchiolitis Obliterans Syndrome After Lung Transplantation	Completed	NCT01212406	Phase 4	Vitamin D
10	Nebulized Hypertonic Saline for Acute Bronchiolitis in the Emergency Department	Completed	NCT01247064	Phase 4	Nebulized 3% saline;Nebulized 0.9% Normal Saline
11	Effects of Reduction of the Length of Treatment by Nebulized 3% Hypertonic Saline From 72 to 24 Hours on Clinical Remission, in Children Younger Than 12 Month Hospitalized for Acute Bronchiolitis. BRONDUSAL	Completed	NCT02538458	Phase 4	3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
12	A Prospective, Open-label Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation	Completed	NCT01109160	Phase 4	Azithromycin Dihydrate
13	Randomized Double-blind Placebo-controlled Prevention Trial of Azithromycin in Lung Transplantation.	Completed	NCT01009619	Phase 4	Azithromycin;Placebo
14	Acute Bronchodilator Responsiveness in Obliterative Bronchiolitis (OB) Following Hematopoietic Stem Cell Transplantation	Completed	NCT01112241	Phase 4	albuterol plus tiotropium
15	The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis: A Multicenter Randomized Controlled Trial	Completed	NCT00119002	Phase 4	dexamethasone;Placebo
16	Impact of the Administration of Systemic Glucocorticoids on Inflammatory Response and Clinical Evolution of Patients Diagnosed With Moderate- Severe Bronchiolitis	Completed	NCT02571517	Phase 4	Glucocorticoids
17	Impact of Oximetry on Hospitalization	Completed	NCT00673946	Phase 4
18	7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial	Completed	NCT01871857	Phase 4	Hypertonic saline and epinephrine;Normal saline and epinephrine
19	Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis	Completed	NCT01300325	Phase 4
20	Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial	Completed	NCT01016249	Phase 4	Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
21	Pilot Study: Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety	Completed	NCT01834820	Phase 4	Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
22	A Randomized Trial of Nebulized 3% Hypertonic Saline With Salbutamol in the Treatment of Acute Bronchiolitis in Pediatric Hospital	Completed	NCT02233985	Phase 4	0.9% Sodium Chloride;3% Sodium Chloride
23	Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation	Completed	NCT01469364	Phase 4	Aztreonam Lysine for Inhalation (AZLI)
24	Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial.	Completed	NCT01276821	Phase 4	L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
25	Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy	Completed	NCT00402805	Phase 4
26	Phase 4 Study of Oral Montelukast Hospitalized Preschool Children	Completed	NCT03369119	Phase 4	Montelukast 4 Mg Oral Granule;Placebos
27	Impact of Vitamin D Supplementation on Recurrent Respiratory Infections in Paediatric	Completed	NCT02617771	Phase 4	Vitamin D3
28	Small Airways Evaluation and Peripherical Effect of Two Bronchodilators in Healthy Subjects and Stable COPD Patients	Completed	NCT01437748	Phase 4	Indacaterol maleate;Tiotropium bromide
29	A Randomized Double-blind Trial Comparing the Effect on Pain of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Nasopharyngeal Aspiration	Completed	NCT01544946	Phase 4	88% sucrose po;placebo po
30	Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life	Completed	NCT02258763	Phase 4	Amoxicillin-Potassium Clavulanate Combination;Placebo
31	Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children	Completed	NCT00968370	Phase 4
32	Randomized Controlled Trial to Compare the Efficacy of High Flow Nasal Cannula Oxygen Therapy vs Low Flow Oxygen Therapy in Bronchiolitis	Recruiting	NCT03015051	Phase 4	Oxygen
33	Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial	Recruiting	NCT03364218	Phase 4	N-Acetyl Cysteine
34	Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing - the INSTAR Study	Recruiting	NCT03889743	Phase 4	Dexamethasone treatment during 3 days;placebo treatment during 3 days
35	Efficacy of Intermittent Tiotropium in Early Childhood Wheezing	Active, not recruiting	NCT03199976	Phase 4	Tiotropium Bromide;Fluticasone Propionate;Salbutamol
36	A Prospective Study on the Use of Hypertonic Saline Inhalation in Acute Bronchiolitis in Children	Not yet recruiting	NCT03880903	Phase 4	normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
37	A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs	Not yet recruiting	NCT02347111	Phase 4	Flecainide;Sotalol
38	Dexamethasone Use for the Treatment of Non-RSV Bronchiolitis	Suspended	NCT04221087	Phase 4	Placebos;Dexamethasone Oral
39	Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study	Terminated	NCT00361452	Phase 4	nebulized epinephrine and nebulized albuterol
40	Effectiveness of Inhaled Corticosteroids in Preschool Children Following Hospital Admission for Acute Dyspnea and Wheeze	Terminated	NCT00962299	Phase 4	Beclomethasone;Placebo
41	Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department	Withdrawn	NCT01660867	Phase 4	3% saline + oral placebo;0.9% saline + oral dexamethasone
42	Nebulized Budesonide After Discharge From a Pediatric Emergency Department in Preventing Asthma Relapse: A Randomized, Double-Blind, Placebo Controlled Trial.	Withdrawn	NCT00584636	Phase 4	pulmicort respules
43	IMLEMENTATION OF High Flow Nasal Cannulae Therapy FOR THE TREATMENT OF BRONCHIOLITIS IN A GENERAL PEDIATRIC WARD - A RETROSPECTIVE AND PROSPECTIVE CLINICAL TRIAL	Unknown status	NCT02366715	Phase 3
44	Comparison Between 2l/Min/kg vs 3l/Min/kg in High Flow Nasal Cannula (HFNC) During the Initial Management of Severe Bronchiolitis in Infants	Unknown status	NCT02824744	Phase 3
45	Open Trial With Randomized Withdrawal of Treatment, to Evaluate the Efficacy of Azithromycin in the Treatment of Children With Non Cystic Fibrosis Bronchiectasis ( AZI-STOP Study )	Unknown status	NCT02531984	Phase 3	Azithromycin
46	Phase III, Randomized, Double Blind Study of Low Dose Long Term Clarithromycin Versus Placebo in Treatment of Chronic Pulmonary Lesions Due to Sulfur Mustard	Completed	NCT00381147	Phase 3	Clarithromycin
47	Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis	Completed	NCT00213226	Phase 3	dexamethasone
48	Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients: a Double-Blind Randomized Study	Completed	NCT00512811	Phase 3	furosemide
49	Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old	Completed	NCT00355043	Phase 3	Zinc sulphate 20 mg
50	A Randomized, 2-Period, Multicenter, Dble-Blind, Parallel-Group Study Comparing Effects of 2 Doses of MK0476 and Placebo in the Tx of Respiratory Symptoms Associated w/ Respiratory Syncytial Virus-Induced Bronchiolitis in Children 3 to 24 Mths	Completed	NCT00076973	Phase 3	montelukast sodium;Comparator: placebo

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

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Genetic Tests for Bronchiolitis

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Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

⁴⁰

Lung, Heart, Bone, Bone Marrow, T Cells, Testes, Neutrophil

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Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 10919)

#	Title	Authors	PMID	Year
1	Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. ⁶¹ ⁵⁴	Nuolivirta K...Helminen M	19773677	2009
2	Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. ⁵⁴ ⁶¹	Tian M...Zhao DY	19005677	2009
3	[Relationship of levels of CD4(+)CD25(+) regulatory T cells and expression of Foxp3 mRNA in peripheral blood with serum immunoglobulin E level in children with bronchiolitis]. ⁶¹ ⁵⁴	Zhu YF...Lin HL	19470254	2009
4	[Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. ⁵⁴ ⁶¹	Zhu P...Zou LP	19470255	2009
5	[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]. ⁵⁴ ⁶¹	Liu JL...Chen ZM	19567118	2009
6	[Association of INF-gamma/A+874T gene polymorphisms with respiratory syncytial virus bronchiolitis]. ⁶¹ ⁵⁴	Dong L...Lin J	19149916	2009
7	[Association between interleukin-8 gene-251 locus polymorphism and respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infants]. ⁵⁴ ⁶¹	Tian M...Chen RH	18282421	2007
8	Immunopathogenesis of respiratory syncytial virus bronchiolitis. ⁵⁴ ⁶¹	Bennett BL...Piedra PA	17436234	2007
9	Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. ⁶¹ ⁵⁴	Boogaard R...Merkus PJFM	17356094	2007
10	Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. ⁶¹ ⁵⁴	Kim HH...Lee JS	17297249	2007
11	[Genetic polymorphisms and infections]. ⁶¹ ⁵⁴	Joram N...Mira JP	16697544	2006
12	Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. ⁶¹ ⁵⁴	Puthothu B...Heinzmann A	16503988	2006
13	Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. ⁵⁴ ⁶¹	Priftis KN...Kanariou M	16192901	2005
14	Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis. ⁵⁴ ⁶¹	Kim CK...Koh YY	15898980	2005
15	Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. ⁶¹ ⁵⁴	Chung HL...Kim SG	15765744	2005
16	Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. ⁶¹ ⁵⁴	Heinzmann A...Deichmann KA	15356575	2004
17	Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. ⁶¹ ⁵⁴	Hacking D...Udalova IA	15085176	2004
18	Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. ⁶¹ ⁵⁴	Jakubzick C...Hogaboam CM	15161635	2004
19	Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. ⁵⁴ ⁶¹	Goetghebuer T...Hull J	15144474	2004
20	Haplotype mapping of the bronchiolitis susceptibility locus near IL8. ⁶¹ ⁵⁴	Hull J...Kwiatkowski DP	14605870	2004
21	Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. ⁵⁴ ⁶¹	Hoebee B...Kimman TG	14722888	2004
22	Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. ⁶¹ ⁵⁴	Kim CK...Koh YY	12847481	2003
23	Respiratory syncytial virus and other respiratory viruses. ⁵⁴ ⁶¹	Welliver RC	12671447	2003
24	Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. ⁶¹ ⁵⁴	Hoebee B...Kimman TG	12508140	2003
25	Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus. ⁵⁴ ⁶¹	Totet A...Nevez G	14736212	2003
26	The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis. ⁵⁴ ⁶¹	Dimova-Yaneva DN...Helms PJ	15366660	2003
27	Steroids fail to down-regulate respiratory syncytial virus-induced IL-8 secretion in infants. ⁶¹ ⁵⁴	Thomas LH...Friedland JS	12193669	2002
28	RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants. ⁵⁴ ⁶¹	Chung HL...Kim SG	12027066	2002
29	DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. ⁵⁴ ⁶¹	Merkus PJ...de Jongste JC	11716180	2001
30	Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. ⁵⁴ ⁶¹	Hull J...Kwiatkowski D	11431705	2001
31	Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. ⁵⁴ ⁶¹	Pifferi M...Baldini G	11389573	2001
32	IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. ⁶¹ ⁵⁴	Abu-Harb M...Everard ML	10489841	1999
33	Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. ⁵⁴ ⁶¹	Harrison AM...Domachowske JB	10351940	1999
34	Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma? ⁶¹ ⁵⁴	Oymar K...Bjerknes R	9920219	1998
35	Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing. ⁵⁴ ⁶¹	Reijonen TM...Remes K	9261851	1997
36	Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis. ⁶¹ ⁵⁴	Reijonen TM...Remes K	9220520	1997
37	Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. ⁶¹ ⁵⁴	Saito T...Garofalo R	9041319	1997
38	Persistence of respiratory syncytial virus (RSV) infection and development of RSV-specific IgG1 response in a guinea-pig model of acute bronchiolitis. ⁵⁴ ⁶¹	Dakhama A...Hegele RG	9032486	1997
39	Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis. ⁶¹ ⁵⁴	Oymar K...Bjerknes R	9151339	1996
40	Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. ⁵⁴ ⁶¹	Sigurs N...Sigurbergsson F	7841728	1994
41	Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus. ⁶¹ ⁵⁴	Colocho Zelaya EA...Strannegard O	8087188	1994
42	Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease. ⁵⁴ ⁶¹	Garofalo R...Welliver RC	8087190	1994
43	Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. ⁵⁴ ⁶¹	Garofalo R...Ogra PL	1731020	1992
44	Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life. ⁶¹	Harvey SM...Jensen ME	32250063	2020
45	Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review. ⁶¹	Zhang BD...Zhang J	32205260	2020
46	Noninvasive methods for detection of chronic lung allograft dysfunction in lung transplantation. ⁶¹	Tian D...Wen HY	32498976	2020
47	Increased Acid Exposure on Pretransplant Impedance-pH Testing Is Associated With Chronic Rejection After Lung Transplantation. ⁶¹	Lo WK...Chan WW	32091450	2020
48	Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs. ⁶¹	Salinas FM...Bueno CA	32387475	2020
49	Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children. ⁶¹	Leiter K...Laing IA	32380236	2020
50	Long-term pulmonary function testing in pediatric bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. ⁶¹	Walther S...Jerkic SP	32369682	2020

Sources

Genes for Bronchiolitis

Genes related to Bronchiolitis (0 elite genes):

(show all 34)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	28.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications Summaries (show sections)	15085176 15356575 15898980 (more) 10351940 10489841 18282421 19567118 15144474 16503988 14605870 11431705 12193669 17436234
2	RNASE3	Ribonuclease A Family Member 3	Protein Coding	20.63	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	9261851 1731020 9220520 (more) 8087190 11389573 8087188 9151339 7841728 15366660 9920219 15898980 9041319 16192901 12027066 10351940 17297249
3	RASSF6	Ras Association Domain Family Member 6	Protein Coding	19.96	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Summaries (show sections)
4	TLR4	Toll Like Receptor 4	Protein Coding	18.55	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	19773677 16697544
5	IL5	Interleukin 5	Protein Coding	17.75	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12847481 9151339
6	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	17.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12027066 19005677 10351940
7	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	17.32	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	10351940 12671447
8	IL13	Interleukin 13	Protein Coding	17.01	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15161635
9	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	16.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	17297249
10	IL4R	Interleukin 4 Receptor	Protein Coding	14.24	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	12508140 14722888
11	IL10	Interleukin 10	Protein Coding	13.97	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	IL4	Interleukin 4	Protein Coding	13.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	TNF	Tumor Necrosis Factor	Protein Coding	13.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	IL6	Interleukin 6	Protein Coding	13.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	IL17A	Interleukin 17A	Protein Coding	13.35	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IFNG	Interferon Gamma	Protein Coding	13.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	TLR3	Toll Like Receptor 3	Protein Coding	13.25	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
18	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	13.02	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	TLR7	Toll Like Receptor 7	Protein Coding	12.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
20	IL11	Interleukin 11	Protein Coding	12.91	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴ GeneCards inferred via : Publications (show sections)	15765744
21	SFTPD	Surfactant Protein D	Protein Coding	12.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
22	TLR9	Toll Like Receptor 9	Protein Coding	12.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
23	TLR6	Toll Like Receptor 6	Protein Coding	12.87	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
24	TLR2	Toll Like Receptor 2	Protein Coding	12.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
25	TLR1	Toll Like Receptor 1	Protein Coding	12.84	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
26	CRP	C-Reactive Protein	Protein Coding	12.8	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
27	IL1A	Interleukin 1 Alpha	Protein Coding	12.75	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
28	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	12.73	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
29	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	12.7	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
30	IFNA1	Interferon Alpha 1	Protein Coding	12.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
31	CD40LG	CD40 Ligand	Protein Coding	12.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
32	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	12.69	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
33	TLR10	Toll Like Receptor 10	Protein Coding	12.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
34	TLR8	Toll Like Receptor 8	Protein Coding	12.59	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Bronchiolitis

ClinVar genetic disease variations for Bronchiolitis:

⁶ ‎‎ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1		46;XX;t(2;3)(q34;p23)	Translocation	Likely pathogenic	267915
2		46;XY;t(16;20)(q23.1;p11.22)	Translocation	Uncertain significance	267924

Sources

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Sources

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	14.09	TNF TLR7 TLR4 TLR3 RNASE3 MUC5AC
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.96	TNF IL6 IL5 IL4R IL4 IL17A
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.81	TNF TLR4 IL6 IL5 IL4R IL4
4	TGF-Beta Pathway ⁶³ Show member pathways JAK-STAT Pathway ⁶³ JNK Pathway ⁶³ MAPK Family Pathway ⁶³ Regulation of eIF4 and p70S6K ⁶³ SOCS Pathway ⁶³	13.69	TNF IL6 IL5 IL4R IL4 IL17A
5	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.51	TNF IL6 IL5 IL4R IL4 IL17A
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.46	TNF IL6 IL5 IL4R IL4 IL17A
7	IL-2 Pathway ⁶³ Show member pathways ErbB Family Pathway ⁶³ ErbB2-ErbB3 Heterodimers ⁶³ ErbB4 Pathway ⁶³ Growth Hormone Signaling ⁶³ HMGB1 Pathway ⁶³ IL-4 Pathway ⁶³ LPS Stimulated MAPK Signaling ⁶³ PACAP Signaling ⁶³ PI3K Signaling in B-Lymphocyte ⁶³ Prolactin Signaling ⁶³ Thrombopoietin Pathway ⁶³ TREM1 Pathway ⁶³ UVC-Induced MAPK Signaling ⁶³	13.28	TNF TLR7 TLR4 TLR3 IL4R IL4
8	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	13.23	TNF TLR7 TLR4 TLR3 IL6 IL10
9	PI3K-Akt signaling pathway ³⁶ Show member pathways Human papillomavirus infection ³⁶	13.06	TNF TLR4 TLR3 IL6 IL4R IL4
10	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	13.06	TNF TLR4 TLR3 IL6 CXCL8 CCL5
11	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	13.05	TNF RNASE3 IL6 IL5 IL4 IL17A
12	Pathways in cancer ³⁶	12.98	IL6 IL5 IL4R IL4 IL13 IFNG
13	Measles ³⁶ Show member pathways Epstein-Barr virus infection ³⁶ Influenza A ³⁶	12.98	TNF TLR7 TLR4 TLR3 IL6 IFNG
14	Toll-Like receptor Signaling Pathways ⁶⁴ Show member pathways IL-1 Family Signaling Pathways ⁶⁴ Immune response IL-1 signaling pathway ²² Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Inflammasome Activation Pathways ⁶⁴ Mucin expression in CF via TLRs, EGFR signaling pathways ²² NOD-like Receptor Signaling Pathways ⁶⁴	12.88	TNF TLR7 TLR4 TLR3 MUC5AC IL6
15	Herpes simplex virus 1 infection ³⁶	12.84	TNF TLR3 IL6 IFNG CCL5
16	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁶ Th1 and Th2 cell differentiation ³⁶	12.81	TNF TLR4 IL6 IL5 IL4R IL4
17	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.79	TNF TLR4 IL6 IL5 IL4 IL17A
18	NF-KappaB Family Pathway ⁶³ Show member pathways NF-KappaB (p50-p65) Pathway ⁶³	12.77	TNF TLR7 TLR4 TLR3 IL6
19	NF-kappaB Signaling ⁴	12.75	TNF TLR7 TLR3 IL4 IL17A IL10
20	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.7	TNF IL4R IL4 IL10 IFNG
21	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.67	TNF IL6 IL17A IL10 IFNG
22	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	12.67	TNF TLR7 TLR4 TLR3 IL6 IL5
23	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.65	IL6 IL5 IL4R IL4 IL13 IL11
24	Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.54	TNF IL6 IL10 CXCL8 CCL5 CCL3
25	Toll Comparative Pathway ⁶³ Show member pathways IL-1 Pathway ⁶³ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶³ TLR-TRIF Pathway ⁶³	12.48	TNF TLR4 TLR3 IL6 IFNG CXCL8
26	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.47	TNF IL6 IL5 IL4 IL17A IL13
27	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.46	TNF IL6 IL4 IFNG CCL5
28	Diseases associated with the TLR signaling cascade ⁶⁵ Show member pathways Diseases of Immune System ⁶⁵ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁵ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁵ IRAK4 deficiency (TLR2/4) ⁶⁵ IRAK4 deficiency (TLR5) ⁶⁵ MyD88 deficiency (TLR2/4) ⁶⁵ MyD88 deficiency (TLR5) ⁶⁵ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.45	TNF TLR7 TLR4 TLR3 IL6 CXCL8
29	Shigellosis ³⁶	12.44	TNF TLR4 CXCL8 CCL5
30	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.44	TNF MUC5AC IL6 IL5 IL4 IL17A
31	Toxoplasmosis ³⁶ Show member pathways Leishmaniasis ³⁶	12.4	TNF TLR4 IL4 IL10 IFNG
32	NOD-like receptor signaling pathway ³⁶	12.38	TNF TLR4 IL6 CXCL8 CCL5
33	Salmonella infection (KEGG) ³⁶	12.37	TNF TLR4 IL6 CXCL8
34	Tuberculosis ³⁶	12.37	TNF TLR4 IL6 IL10 IFNG
35	Colorectal Cancer Metastasis ⁶³	12.37	TNF TLR7 TLR4 TLR3 IL6 IFNG
36	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.37	TNF TLR7 TLR4 IL6 IL4 IL11
37	Pathogenic Escherichia coli infection ³⁶	12.33	TNF TLR4 IL6 CXCL8
38	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.32	TNF IL6 IL13 IL10 CXCL8
39	Necroptosis ³⁶ Show member pathways Nanoparticle triggered regulated necrosis ¹	12.27	TNF TLR4 TLR3 IFNG
40	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	12.23	TNF IL6 IL5 IL4 IL11 IL10
41	Spinal Cord Injury ¹	12.22	TNF TLR4 IL6 IL4 IFNG CXCL8
42	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	12.2	TLR7 TLR4 TLR3 IL5 IL13
43	Yersinia infection ³⁶	12.18	TNF TLR4 IL6 IL10 CXCL8
44	IL27-mediated signaling events ¹ Show member pathways IL12 Signaling Pathway ⁶⁶ Th1 Differentiation ⁶⁴	12.17	TNF TLR7 TLR4 TLR3 IL6 IL17A
45	Amoebiasis ³⁶	12.14	TNF TLR4 IL6 IL10 IFNG CXCL8
46	Hematopoietic cell lineage ³⁶	12.13	TNF IL6 IL5 IL4R IL4 IL11
47	Interleukin-4 and 13 signaling ⁶⁵	12.08	TNF IL6 IL4R IL4 IL17A IL13
48	Th17 Differentiation ⁶⁴ Show member pathways IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴	12.07	TLR7 TLR4 TLR3 IL6 IL4R IL4
49	Senescence and Autophagy in Cancer ¹	12.06	IL6 IFNG CXCL8 CCL3
50	Glucocorticoid receptor regulatory network ¹	12.02	IL6 IL5 IL4 IL13 IFNG CXCL8

Sources

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.86	TNF RNASE3 MUC5AC IL6 IL5 IL4R
2	extracellular space	GO:0005615	9.55	TNF TLR3 RNASE3 MUC5AC IL6 IL5

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 95)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.3	TNF TLR4 TLR3 IL6 IL4 IL17A
2	signal transduction	GO:0007165	10.21	TLR7 TLR4 TLR3 RASSF6 IL6 IL5
3	positive regulation of gene expression	GO:0010628	10.14	TNF TLR4 TLR3 IL6 IL4 IL13
4	defense response to bacterium	GO:0042742	10.1	TNF TLR4 TLR3 RNASE3 IL10
5	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.08	TNF TLR4 CCL5 CCL3 CCL11
6	positive regulation of cell migration	GO:0030335	10.07	IL4 CCL5 CCL3 CCL11
7	defense response to virus	GO:0051607	10.06	TLR7 TLR3 IL6 IFNG
8	cellular response to lipopolysaccharide	GO:0071222	10.06	TNF TLR4 IL6 IL10 CXCL8
9	chemotaxis	GO:0006935	10.04	CXCL8 CCL5 CCL3 CCL11
10	positive regulation of NF-kappaB transcription factor activity	GO:0051092	10.03	TNF TLR4 TLR3 IL6
11	cellular response to tumor necrosis factor	GO:0071356	10.02	CXCL8 CCL5 CCL3 CCL11
12	positive regulation of DNA-binding transcription factor activity	GO:0051091	10.01	TNF IL6 IL5 IL10
13	response to virus	GO:0009615	10	TNF TLR3 IFNG CCL5 CCL11
14	cellular response to mechanical stimulus	GO:0071260	9.98	TLR7 TLR4 TLR3 IL13
15	cellular response to interferon-gamma	GO:0071346	9.98	TLR4 TLR3 CCL5 CCL3 CCL11
16	neutrophil chemotaxis	GO:0030593	9.97	CXCL8 CCL5 CCL3 CCL11
17	chemokine-mediated signaling pathway	GO:0070098	9.97	CXCL8 CCL5 CCL3 CCL11
18	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.97	TNF TLR7 TLR4 TLR3
19	cellular response to interleukin-1	GO:0071347	9.97	IL17A CXCL8 CCL5 CCL3 CCL11
20	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.96	TNF TLR7 TLR4 TLR3
21	positive regulation of JNK cascade	GO:0046330	9.95	TNF TLR4 TLR3
22	positive regulation of smooth muscle cell proliferation	GO:0048661	9.95	TNF IL6 IL13 CCL5
23	B cell differentiation	GO:0030183	9.94	IL4 IL11 IL10
24	regulation of insulin secretion	GO:0050796	9.94	TNF IFNG CCL5
25	cellular response to organic cyclic compound	GO:0071407	9.94	TNF CCL5 CCL3
26	apoptotic signaling pathway	GO:0097190	9.94	TNF TLR4 TLR3
27	response to glucocorticoid	GO:0051384	9.94	TNF IL6 IL10
28	positive regulation of T cell proliferation	GO:0042102	9.93	IL6 IL4 CCL5
29	humoral immune response	GO:0006959	9.93	TNF IL6 IFNG
30	monocyte chemotaxis	GO:0002548	9.93	IL6 CCL5 CCL3 CCL11
31	positive regulation of inflammatory response	GO:0050729	9.93	TNF TLR7 TLR4 TLR3 IFNG CCL3
32	inflammatory response	GO:0006954	9.93	TNF TLR7 TLR4 TLR3 IL6 IL5
33	positive regulation of tumor necrosis factor production	GO:0032760	9.92	TLR4 TLR3 CCL3
34	positive regulation of interleukin-6 secretion	GO:2000778	9.92	TNF TLR4 IL17A IFNG
35	extrinsic apoptotic signaling pathway	GO:0097191	9.91	TNF TLR3 IFNG
36	toll-like receptor signaling pathway	GO:0002224	9.91	TLR7 TLR4 TLR3
37	positive regulation of B cell proliferation	GO:0030890	9.91	TLR4 IL5 IL4 IL13
38	positive regulation of interleukin-6 production	GO:0032755	9.91	TNF TLR7 TLR4 TLR3 IL6
39	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.9	TNF TLR4 IFNG
40	protein kinase B signaling	GO:0043491	9.9	TNF CCL5 CCL3
41	lymphocyte chemotaxis	GO:0048247	9.9	CCL5 CCL3 CCL11
42	negative regulation of endothelial cell apoptotic process	GO:2000352	9.9	IL4 IL13 IL11 IL10
43	negative regulation of interleukin-6 production	GO:0032715	9.89	TNF TLR4 IL10
44	positive regulation of cytokine secretion	GO:0050715	9.89	TNF IL10 IFNG
45	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.89	TNF TLR4 CCL5 CCL3
46	negative regulation of neurogenesis	GO:0050768	9.88	TNF IL6 CCL11
47	positive regulation of interleukin-8 production	GO:0032757	9.88	TNF TLR7 TLR4 TLR3
48	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.88	TNF IL6 IL4 IL13 IFNG CCL5
49	positive regulation of interleukin-12 production	GO:0032735	9.87	TLR4 TLR3 IFNG
50	eosinophil chemotaxis	GO:0048245	9.86	CCL5 CCL3 CCL11

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	10.23	TNF TLR7 TLR4 TLR3 RASSF6 MUC5AC
2	growth factor activity	GO:0008083	9.55	IL6 IL5 IL4 IL11 IL10
3	CCR chemokine receptor binding	GO:0048020	9.5	CCL5 CCL3 CCL11
4	cytokine activity	GO:0005125	9.44	TNF IL6 IL5 IL4 IL17A IL13
5	CCR5 chemokine receptor binding	GO:0031730	9.43	CCL5 CCL3
6	phospholipase activator activity	GO:0016004	9.4	CCL5 CCL3
7	CCR1 chemokine receptor binding	GO:0031726	9.37	CCL5 CCL3
8	chemokine activity	GO:0008009	9.26	CXCL8 CCL5 CCL3 CCL11

Sources

Sources for Bronchiolitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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¹⁰ dbSNP

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²³ GeneHancer via GeneCards

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²⁷ GEO DataSets

²⁸ GO

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³³ ICD10 via Orphanet

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³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

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³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

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⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia