MCID: BRN002
MIFTS: 59

Bronchiolitis

Categories: Respiratory diseases, Skin diseases

Aliases & Classifications for Bronchiolitis

MalaCards integrated aliases for Bronchiolitis:

Name: Bronchiolitis 12 54 6 3 43 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2942
MeSH 43 D001988
NCIt 49 C39658
SNOMED-CT 67 4120002
UMLS 71 C0006271

Summaries for Bronchiolitis

CDC : 3 Respiratory syncytial (sin-SISH-uhl) virus, or RSV, is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover in a week or two, but RSV can be serious, especially for infants and older adults. In fact, RSV is the most common cause of bronchiolitis (inflammation of the small airways in the lung) and pneumonia (infection of the lungs) in children younger than 1 year of age in the United States. It is also a significant cause of respiratory illness in older adults.

MalaCards based summary : Bronchiolitis is related to bronchiolitis obliterans and bronchopneumonia, and has symptoms including fever, cough and wheezing. An important gene associated with Bronchiolitis is CXCL8 (C-X-C Motif Chemokine Ligand 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Bromhexine and Macitentan have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and bone, and related phenotypes are hematopoietic system and immune system

Disease Ontology : 12 A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has symptom cough, has symptom wheezing, has symptom shortness of breath, has symptom fever, has symptom nasal flaring in infants and has symptom bluish skin due to lack of oxygen.

Wikipedia : 74 Bronchiolitis is blockage of the small airways in the lungs due to a viral infection. It usually only... more...

Related Diseases for Bronchiolitis

Diseases related to Bronchiolitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 904)
# Related Disease Score Top Affiliating Genes
1 bronchiolitis obliterans 34.5 TNF TLR4 IL6 IL17A IL13 IL10
2 bronchopneumonia 32.9 TNF TLR4 IL6 IL10 CXCL8
3 extrinsic allergic alveolitis 32.6 IL6 IL10 CXCL8 CCL5 CCL3
4 idiopathic interstitial pneumonia 32.6 IL4R IL4 IL13 IFNG CXCL8
5 bronchitis 31.8 TNF TLR4 RNASE3 IL6 IL5 IL4
6 graft-versus-host disease 31.7 TNF IL6 IL10 IFNG
7 chronic graft versus host disease 31.7 IL10 IFNG
8 cytokine deficiency 31.4 IL5 IL13
9 pemphigus 31.3 TNF IL6 IL4 IL10
10 haemophilus influenzae 31.1 TNF CXCL8
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 IL17A IL10 IFNG
12 acute graft versus host disease 31.0 TNF IL4 IL10 IFNG
13 vasculitis 31.0 TNF IL6 IL17A IL10
14 ige responsiveness, atopic 31.0 RNASE3 IL5 IL4R IL4 IL13 IL10
15 acute cystitis 31.0 TNF TLR4 IL6 IL10 CXCL8
16 connective tissue disease 31.0 TNF IL6 IL4 IL17A IL10 IFNG
17 vascular disease 30.9 TNF TLR4 IL6 IL10 IFNG
18 exanthem 30.9 TNF IL6 IL10 IFNG CXCL8
19 histiocytosis 30.8 TNF IL17A IFNG
20 pulmonary edema 30.8 TNF IL13 IL10 CXCL8
21 gastroesophageal reflux 30.7 TNF IL6 IL5 IL4 CXCL8 CCL11
22 cytomegalovirus infection 30.7 TNF IL6 CXCL8 CCL5 CCL3
23 bacteriuria 30.6 TLR4 IL6 CXCL8
24 erythema multiforme 30.6 TNF IL6 IL5 IL4 IL13 IFNG
25 lymphopenia 30.6 IL6 IL4 IL10 IFNG
26 juvenile arthritis 30.6 IL6 IL10 CXCL8
27 respiratory failure 30.6 TNF TLR4 RNASE3 MUC5AC IL6 IL5
28 lung abscess 30.6 TNF IL6 IFNG
29 juvenile rheumatoid arthritis 30.6 TNF IL6 IL10 IFNG CXCL8
30 interstitial lung disease 30.6 TNF IL6 IL5 IL4 IL17A IL13
31 bronchial disease 30.6 TNF TLR7 TLR4 TLR3 RNASE3 MUC5AC
32 cystic fibrosis 30.5 TNF TLR4 RNASE3 MUC5AC IL6 IL17A
33 pertussis 30.5 TNF TLR4 IL6 IL10 CXCL8 CCL5
34 hypereosinophilic syndrome 30.5 RNASE3 IL5 IL4 IL13 IL10 IFNG
35 stevens-johnson syndrome/toxic epidermal necrolysis 30.5 IL5 IL13 IFNG CCL5
36 granulomatosis with polyangiitis 30.5 TNF TLR4 IL5 IL17A
37 sudden infant death syndrome 30.5 TNF IL6 IL13 IL10 CXCL8
38 thyroiditis 30.5 TNF IL6 IL4 IL10
39 cryoglobulinemia 30.5 TNF IL6 IL10 IFNG
40 mixed connective tissue disease 30.5 TNF IL6 IL10 IFNG
41 spondylitis 30.5 TNF IL6 IL17A IL10 IFNG
42 adult respiratory distress syndrome 30.4 TNF IL6 IL10 CXCL8
43 cryptococcosis 30.4 TNF IL4 IL17A IL13 IL10 IFNG
44 thymoma 30.4 TNF IL6 IL4 IL17A
45 pustulosis of palm and sole 30.4 TNF IL17A CXCL8
46 crohn's colitis 30.4 TNF IFNG CXCL8
47 eosinophilic fasciitis 30.4 IL5 IFNG
48 eosinophilic pneumonia 30.4 RNASE3 IL6 IL5 IL4 IL13 CXCL8
49 peptic esophagitis 30.4 TNF IL6 CXCL8
50 post-transplant lymphoproliferative disease 30.4 TNF IL6 IL10

Graphical network of the top 20 diseases related to Bronchiolitis:



Diseases related to Bronchiolitis

Symptoms & Phenotypes for Bronchiolitis

Symptoms:

12
  • fever
  • cough
  • wheezing
  • shortness of breath
  • nasal flaring in infants
  • bluish skin due to lack of oxygen

MGI Mouse Phenotypes related to Bronchiolitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 CCL11 CCL5 IFNG IL10 IL13 IL17A
2 immune system MP:0005387 10.2 CCL11 CCL5 IFNG IL10 IL13 IL17A
3 homeostasis/metabolism MP:0005376 10.18 IFNG IL10 IL13 IL17A IL4 IL4R
4 digestive/alimentary MP:0005381 10.17 IFNG IL10 IL13 IL17A IL4 IL4R
5 integument MP:0010771 9.91 IFNG IL10 IL13 IL17A IL4 IL4R
6 liver/biliary system MP:0005370 9.76 IFNG IL10 IL4 IL4R IL5 IL6
7 neoplasm MP:0002006 9.5 IFNG IL10 IL5 IL6 TLR3 TLR4
8 respiratory system MP:0005388 9.4 CCL11 IFNG IL10 IL13 IL17A IL4

Drugs & Therapeutics for Bronchiolitis

Drugs for Bronchiolitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 214)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bromhexine Approved Phase 4 3572-43-8
2
Macitentan Approved Phase 4 441798-33-0
3
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560 441411
4
Mechlorethamine Approved, Investigational Phase 4 51-75-2 4033
5
Clarithromycin Approved Phase 4 81103-11-9 84029
6
Montelukast Approved Phase 4 158966-92-8 5281040
7
Aztreonam Approved Phase 4 78110-38-0 5742832 5362041
8
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
9
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
10
Ceftriaxone Approved Phase 4 73384-59-5 5361919 5479530
11
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
12
Sotalol Approved Phase 4 3930-20-9, 959-24-0 5253
13
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
14
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
15
Maleic acid Experimental, Investigational Phase 4 110-17-8, 110-16-7 444972
16 Endothelin A Receptor Antagonists Phase 4
17 Endothelin Receptor Antagonists Phase 4
18 Erythromycin Estolate Phase 4
19 Erythromycin stearate Phase 4
20 Erythromycin Ethylsuccinate Phase 4
21 Cytochrome P-450 Enzyme Inhibitors Phase 4
22 Cytochrome P-450 CYP3A Inhibitors Phase 4
23 Leukotriene Antagonists Phase 4
24 Trace Elements Phase 4
25 Micronutrients Phase 4
26 lysine Phase 4
27 Retinol palmitate Phase 4
28 retinol Phase 4
29 Amoxicillin-Potassium Clavulanate Combination Phase 4
30 beta-Lactamase Inhibitors Phase 4
31 Protective Agents Phase 4
32 Antiviral Agents Phase 4
33 Antioxidants Phase 4
34 Antidotes Phase 4
35 Expectorants Phase 4
36 N-monoacetylcystine Phase 4
37 Albuterol Phase 4
38 Parasympatholytics Phase 4
39 Cholinergic Agents Phase 4
40 Cholinergic Antagonists Phase 4
41 Tiotropium Bromide Phase 4 136310-93-5
42 Bromides Phase 4
43 Anticonvulsants Phase 4
44 Anti-Arrhythmia Agents Phase 4
45 Sodium Channel Blockers Phase 4
46 Adrenergic Antagonists Phase 4
47 Sympatholytics Phase 4
48 Adrenergic beta-Antagonists Phase 4
49 Diuretics, Potassium Sparing Phase 4
50 BB 1101 Phase 4

Interventional clinical trials:

(show top 50) (show all 448)
# Name Status NCT ID Phase Drugs
1 Home Oxygen Therapy in the Ambulatory Treatment of Bronchiolitis Unknown status NCT01216553 Phase 4
2 Bronchiolitis All-study, SE-Norway What is the Optimal Inhalation Treatment for Children 0-12 Months With Acute Bronchiolitis? Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
3 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
4 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
5 Potential Therapy With MACITENTAN in the Treatment of Chronic Lung Allograft Dysfunction (CLAD) After Lung Transplantation Unknown status NCT02893176 Phase 4 macitentan;placebo (for macitentan)
6 Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans Completed NCT00367419 Phase 4 Erythromycin
7 Chronic Bronchiolitis or Resistant Asthma? Completed NCT00368342 Phase 4 Erythromycin, Azithromycin , Clarithromycin
8 A Randomized, Double Blind, Placebo Controlled Trial With Montelukast to Treat Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01211509 Phase 4 Montelukast
9 A Randomized Double Blind Placebo Controlled Trial With Vitamin D to Prevent Bronchiolitis Obliterans Syndrome After Lung Transplantation Completed NCT01212406 Phase 4 Vitamin D
10 Nebulized Hypertonic Saline for Acute Bronchiolitis in the Emergency Department Completed NCT01247064 Phase 4 Nebulized 3% saline;Nebulized 0.9% Normal Saline
11 Effects of Reduction of the Length of Treatment by Nebulized 3% Hypertonic Saline From 72 to 24 Hours on Clinical Remission, in Children Younger Than 12 Month Hospitalized for Acute Bronchiolitis. BRONDUSAL Completed NCT02538458 Phase 4 3 % hypertonic saline up to 72H;3 % hypertonic saline up to 24H
12 A Prospective, Open-label Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
13 Randomized Double-blind Placebo-controlled Prevention Trial of Azithromycin in Lung Transplantation. Completed NCT01009619 Phase 4 Azithromycin;Placebo
14 Acute Bronchodilator Responsiveness in Obliterative Bronchiolitis (OB) Following Hematopoietic Stem Cell Transplantation Completed NCT01112241 Phase 4 albuterol plus tiotropium
15 The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis: A Multicenter Randomized Controlled Trial Completed NCT00119002 Phase 4 dexamethasone;Placebo
16 Impact of the Administration of Systemic Glucocorticoids on Inflammatory Response and Clinical Evolution of Patients Diagnosed With Moderate- Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
17 Impact of Oximetry on Hospitalization Completed NCT00673946 Phase 4
18 7% Hypertonic Saline for Acute Bronchiolitis: A Randomized Controlled Trial Completed NCT01871857 Phase 4 Hypertonic saline and epinephrine;Normal saline and epinephrine
19 Effectiveness of Nebulized Hypertonic Saline and Epinephrine in Hospitalized Infants With Bronchiolitis Completed NCT01300325 Phase 4
20 Nebulized 5% Hypertonic Saline for Infirmary Treatment of Acute Infant Bronchiolitis: A Randomized Trial Completed NCT01016249 Phase 4 Treatment 1. (5% Hypertonic saline + Epinephrine);Treatment 3. (3% Hypertonic saline + Epinephrine);Treatment 2. (Normal saline + Epinephrine)
21 Pilot Study: Epinephrine, Dexamethasone, and Hypertonic Saline in Children With Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
22 A Randomized Trial of Nebulized 3% Hypertonic Saline With Salbutamol in the Treatment of Acute Bronchiolitis in Pediatric Hospital Completed NCT02233985 Phase 4 0.9% Sodium Chloride;3% Sodium Chloride
23 Aztreonam Lysine for Inhalation (AZLI) in the Treatment of Early Bronchiolitis Obliterans Syndrome (BOS) After Lung Transplantation Completed NCT01469364 Phase 4 Aztreonam Lysine for Inhalation (AZLI)
24 Efficacy of Nebulised Hypertonic Saline (3%) Among Children With Mild to Moderately Severe Bronchiolitis - A Double Blind Randomized Controlled Trial. Completed NCT01276821 Phase 4 L-Epinephrine and Normal Saline (0.9%);L-Epinephrine and Hypertonic Saline (3%)
25 Improving the Humoral Response to Influenza Vaccine in Lung Transplant Recipients by an Intradermal Strategy Completed NCT00402805 Phase 4
26 Phase 4 Study of Oral Montelukast Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
27 Impact of Vitamin D Supplementation on Recurrent Respiratory Infections in Paediatric Completed NCT02617771 Phase 4 Vitamin D3
28 Small Airways Evaluation and Peripherical Effect of Two Bronchodilators in Healthy Subjects and Stable COPD Patients Completed NCT01437748 Phase 4 Indacaterol maleate;Tiotropium bromide
29 A Randomized Double-blind Trial Comparing the Effect on Pain of an Oral Sucrose Solution Versus Placebo in Children 1 to 3 Months Old Needing Nasopharyngeal Aspiration Completed NCT01544946 Phase 4 88% sucrose po;placebo po
30 Pneumonia in Children: Aetiology, Ideal Antibiotic Duration, Quality of Life Completed NCT02258763 Phase 4 Amoxicillin-Potassium Clavulanate Combination;Placebo
31 Randomized, Controlled Clinical Trial of Day-care Based and Hospitalized Management of Severe and Very Severe Pneumonia, With Severe Malnutrition, With/Without Associated Co-morbidities in Children Completed NCT00968370 Phase 4
32 Randomized Controlled Trial to Compare the Efficacy of High Flow Nasal Cannula Oxygen Therapy vs Low Flow Oxygen Therapy in Bronchiolitis Recruiting NCT03015051 Phase 4 Oxygen
33 Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial Recruiting NCT03364218 Phase 4 N-Acetyl Cysteine
34 Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing - the INSTAR Study Recruiting NCT03889743 Phase 4 Dexamethasone treatment during 3 days;placebo treatment during 3 days
35 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Active, not recruiting NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
36 A Prospective Study on the Use of Hypertonic Saline Inhalation in Acute Bronchiolitis in Children Not yet recruiting NCT03880903 Phase 4 normal saline and salbutamol;hypertonic saline and salbutamol;Hypertonic saline
37 A Prospective, Multi-Center, Randomized, Open Label Trial to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs Not yet recruiting NCT02347111 Phase 4 Flecainide;Sotalol
38 Dexamethasone Use for the Treatment of Non-RSV Bronchiolitis Suspended NCT04221087 Phase 4 Placebos;Dexamethasone Oral
39 Acoustic Assessment of Nebulized Epinephrine Versus Albuterol for RSV Bronchiolitis- a Double Blind Study Terminated NCT00361452 Phase 4 nebulized epinephrine and nebulized albuterol
40 Effectiveness of Inhaled Corticosteroids in Preschool Children Following Hospital Admission for Acute Dyspnea and Wheeze Terminated NCT00962299 Phase 4 Beclomethasone;Placebo
41 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Withdrawn NCT01660867 Phase 4 3% saline + oral placebo;0.9% saline + oral dexamethasone
42 Nebulized Budesonide After Discharge From a Pediatric Emergency Department in Preventing Asthma Relapse: A Randomized, Double-Blind, Placebo Controlled Trial. Withdrawn NCT00584636 Phase 4 pulmicort respules
43 IMLEMENTATION OF High Flow Nasal Cannulae Therapy FOR THE TREATMENT OF BRONCHIOLITIS IN A GENERAL PEDIATRIC WARD - A RETROSPECTIVE AND PROSPECTIVE CLINICAL TRIAL Unknown status NCT02366715 Phase 3
44 Comparison Between 2l/Min/kg vs 3l/Min/kg in High Flow Nasal Cannula (HFNC) During the Initial Management of Severe Bronchiolitis in Infants Unknown status NCT02824744 Phase 3
45 Open Trial With Randomized Withdrawal of Treatment, to Evaluate the Efficacy of Azithromycin in the Treatment of Children With Non Cystic Fibrosis Bronchiectasis ( AZI-STOP Study ) Unknown status NCT02531984 Phase 3 Azithromycin
46 Phase III, Randomized, Double Blind Study of Low Dose Long Term Clarithromycin Versus Placebo in Treatment of Chronic Pulmonary Lesions Due to Sulfur Mustard Completed NCT00381147 Phase 3 Clarithromycin
47 Efficacy of Single Dose Versus Multiple Doses of Dexamethasone in Outpatients With Acute Bronchiolitis Completed NCT00213226 Phase 3 dexamethasone
48 Furosemide Inhalation in Dyspnea of Mustard Gas Exposed Patients: a Double-Blind Randomized Study Completed NCT00512811 Phase 3 furosemide
49 Efficacy of Zinc in the Treatment of Bronchiolitis and Prevention of Wheezing Respiratory Illness in Children Less Than Two Years Old Completed NCT00355043 Phase 3 Zinc sulphate 20 mg
50 A Randomized, 2-Period, Multicenter, Dble-Blind, Parallel-Group Study Comparing Effects of 2 Doses of MK0476 and Placebo in the Tx of Respiratory Symptoms Associated w/ Respiratory Syncytial Virus-Induced Bronchiolitis in Children 3 to 24 Mths Completed NCT00076973 Phase 3 montelukast sodium;Comparator: placebo

Search NIH Clinical Center for Bronchiolitis

Cochrane evidence based reviews: bronchiolitis

Genetic Tests for Bronchiolitis

Anatomical Context for Bronchiolitis

MalaCards organs/tissues related to Bronchiolitis:

40
Lung, Heart, Bone, Bone Marrow, T Cells, Testes, Neutrophil

Publications for Bronchiolitis

Articles related to Bronchiolitis:

(show top 50) (show all 10919)
# Title Authors PMID Year
1
Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis. 61 54
19773677 2009
2
Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China. 54 61
19005677 2009
3
[Relationship of levels of CD4(+)CD25(+) regulatory T cells and expression of Foxp3 mRNA in peripheral blood with serum immunoglobulin E level in children with bronchiolitis]. 61 54
19470254 2009
4
[Expression of CD40 and CD40 ligand in peripheral blood mononuclear cells in children with bronchiolitis]. 54 61
19470255 2009
5
[Neutrophil activation and protease imbalance in respiratory tract of infants with respiratory syncytial virus bronchiolitis]. 54 61
19567118 2009
6
[Association of INF-gamma/A+874T gene polymorphisms with respiratory syncytial virus bronchiolitis]. 61 54
19149916 2009
7
[Association between interleukin-8 gene-251 locus polymorphism and respiratory syncytial virus bronchiolitis and post-bronchiolitis wheezing in infants]. 54 61
18282421 2007
8
Immunopathogenesis of respiratory syncytial virus bronchiolitis. 54 61
17436234 2007
9
Recombinant human deoxyribonuclease in infants with respiratory syncytial virus bronchiolitis. 61 54
17356094 2007
10
Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis. 61 54
17297249 2007
11
[Genetic polymorphisms and infections]. 61 54
16697544 2006
12
Impact of IL8 and IL8-receptor alpha polymorphisms on the genetics of bronchial asthma and severe RSV infections. 61 54
16503988 2006
13
Serum eosinophil cationic protein and CD23 in acute RSV bronchiolitis. 54 61
16192901 2005
14
Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis. 54 61
15898980 2005
15
Relationship between atopic status and nasal interleukin 10 and 11 levels in infants with respiratory syncytial virus bronchiolitis. 61 54
15765744 2005
16
Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis. 61 54
15356575 2004
17
Increased in vivo transcription of an IL-8 haplotype associated with respiratory syncytial virus disease-susceptibility. 61 54
15085176 2004
18
Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. 61 54
15161635 2004
19
Genetic predisposition to wheeze following respiratory syncytial virus bronchiolitis. 54 61
15144474 2004
20
Haplotype mapping of the bronchiolitis susceptibility locus near IL8. 61 54
14605870 2004
21
Influence of promoter variants of interleukin-10, interleukin-9, and tumor necrosis factor-alpha genes on respiratory syncytial virus bronchiolitis. 54 61
14722888 2004
22
Bronchoalveolar lavage cytokine profiles in acute asthma and acute bronchiolitis. 61 54
12847481 2003
23
Respiratory syncytial virus and other respiratory viruses. 54 61
12671447 2003
24
Association of severe respiratory syncytial virus bronchiolitis with interleukin-4 and interleukin-4 receptor alpha polymorphisms. 61 54
12508140 2003
25
Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus. 54 61
14736212 2003
26
The role of leukotrienes and eosinophil cationic protein in acute respiratory syncytial virus bronchiolitis. 54 61
15366660 2003
27
Steroids fail to down-regulate respiratory syncytial virus-induced IL-8 secretion in infants. 61 54
12193669 2002
28
RANTES may be predictive of later recurrent wheezing after respiratory syncytial virus bronchiolitis in infants. 54 61
12027066 2002
29
DNase treatment for atelectasis in infants with severe respiratory syncytial virus bronchiolitis. 54 61
11716180 2001
30
Unusual haplotypic structure of IL8, a susceptibility locus for a common respiratory virus. 54 61
11431705 2001
31
Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. 54 61
11389573 2001
32
IL-8 and neutrophil elastase levels in the respiratory tract of infants with RSV bronchiolitis. 61 54
10489841 1999
33
Respiratory syncytical virus-induced chemokine expression in the lower airways: eosinophil recruitment and degranulation. 54 61
10351940 1999
34
Is serum eosinophil cationic protein in bronchiolitis a predictor of asthma? 61 54
9920219 1998
35
Nasopharyngeal eosinophil cationic protein in bronchiolitis: relation to viral findings and subsequent wheezing. 54 61
9261851 1997
36
Serum eosinophil cationic protein as a predictor of wheezing after bronchiolitis. 61 54
9220520 1997
37
Respiratory syncytial virus induces selective production of the chemokine RANTES by upper airway epithelial cells. 61 54
9041319 1997
38
Persistence of respiratory syncytial virus (RSV) infection and development of RSV-specific IgG1 response in a guinea-pig model of acute bronchiolitis. 54 61
9032486 1997
39
Serum eosinophil cationic protein and interleukin-5 in children with bronchial asthma and acute bronchiolitis. 61 54
9151339 1996
40
Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. 54 61
7841728 1994
41
Eosinophil cationic protein in nasopharyngeal secretions and serum of infants infected with respiratory syncytial virus. 61 54
8087188 1994
42
Peripheral blood eosinophil counts and eosinophil cationic protein content of respiratory secretions in bronchiolitis: relationship to severity of disease. 54 61
8087190 1994
43
Eosinophil degranulation in the respiratory tract during naturally acquired respiratory syncytial virus infection. 54 61
1731020 1992
44
Maternal asthma, breastfeeding, and respiratory outcomes in the first year of life. 61
32250063 2020
45
Sauropus androgynus L. Merr.-A phytochemical, pharmacological and toxicological review. 61
32205260 2020
46
Noninvasive methods for detection of chronic lung allograft dysfunction in lung transplantation. 61
32498976 2020
47
Increased Acid Exposure on Pretransplant Impedance-pH Testing Is Associated With Chronic Rejection After Lung Transplantation. 61
32091450 2020
48
Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs. 61
32387475 2020
49
Vitamin D receptor polymorphisms are associated with severity of wheezing illnesses and asthma exacerbations in children. 61
32380236 2020
50
Long-term pulmonary function testing in pediatric bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation. 61
32369682 2020

Variations for Bronchiolitis

ClinVar genetic disease variations for Bronchiolitis:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 46;XX;t(2;3)(q34;p23)Translocation Likely pathogenic 267915
2 46;XY;t(16;20)(q23.1;p11.22)Translocation Uncertain significance 267924

Expression for Bronchiolitis

Search GEO for disease gene expression data for Bronchiolitis.

Pathways for Bronchiolitis

Pathways related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 TNF TLR7 TLR4 TLR3 RNASE3 MUC5AC
2
Show member pathways
13.96 TNF IL6 IL5 IL4R IL4 IL17A
3
Show member pathways
13.81 TNF TLR4 IL6 IL5 IL4R IL4
4
Show member pathways
13.69 TNF IL6 IL5 IL4R IL4 IL17A
5
Show member pathways
13.51 TNF IL6 IL5 IL4R IL4 IL17A
6
Show member pathways
13.46 TNF IL6 IL5 IL4R IL4 IL17A
7
Show member pathways
13.28 TNF TLR7 TLR4 TLR3 IL4R IL4
8
Show member pathways
13.23 TNF TLR7 TLR4 TLR3 IL6 IL10
9
Show member pathways
13.06 TNF TLR4 TLR3 IL6 IL4R IL4
10
Show member pathways
13.06 TNF TLR4 TLR3 IL6 CXCL8 CCL5
11
Show member pathways
13.05 TNF RNASE3 IL6 IL5 IL4 IL17A
12 12.98 IL6 IL5 IL4R IL4 IL13 IFNG
13
Show member pathways
12.98 TNF TLR7 TLR4 TLR3 IL6 IFNG
14
Show member pathways
12.88 TNF TLR7 TLR4 TLR3 MUC5AC IL6
15 12.84 TNF TLR3 IL6 IFNG CCL5
16
Show member pathways
12.81 TNF TLR4 IL6 IL5 IL4R IL4
17
Show member pathways
12.79 TNF TLR4 IL6 IL5 IL4 IL17A
18
Show member pathways
12.77 TNF TLR7 TLR4 TLR3 IL6
19 12.75 TNF TLR7 TLR3 IL4 IL17A IL10
20
Show member pathways
12.7 TNF IL4R IL4 IL10 IFNG
21
Show member pathways
12.67 TNF IL6 IL17A IL10 IFNG
22
Show member pathways
12.67 TNF TLR7 TLR4 TLR3 IL6 IL5
23
Show member pathways
12.65 IL6 IL5 IL4R IL4 IL13 IL11
24
Show member pathways
12.54 TNF IL6 IL10 CXCL8 CCL5 CCL3
25
Show member pathways
12.48 TNF TLR4 TLR3 IL6 IFNG CXCL8
26
Show member pathways
12.47 TNF IL6 IL5 IL4 IL17A IL13
27
Show member pathways
12.46 TNF IL6 IL4 IFNG CCL5
28
Show member pathways
12.45 TNF TLR7 TLR4 TLR3 IL6 CXCL8
29 12.44 TNF TLR4 CXCL8 CCL5
30
Show member pathways
12.44 TNF MUC5AC IL6 IL5 IL4 IL17A
31
Show member pathways
12.4 TNF TLR4 IL4 IL10 IFNG
32 12.38 TNF TLR4 IL6 CXCL8 CCL5
33 12.37 TNF TLR4 IL6 CXCL8
34 12.37 TNF TLR4 IL6 IL10 IFNG
35 12.37 TNF TLR7 TLR4 TLR3 IL6 IFNG
36
Show member pathways
12.37 TNF TLR7 TLR4 IL6 IL4 IL11
37 12.33 TNF TLR4 IL6 CXCL8
38 12.32 TNF IL6 IL13 IL10 CXCL8
39
Show member pathways
12.27 TNF TLR4 TLR3 IFNG
40 12.23 TNF IL6 IL5 IL4 IL11 IL10
41 12.22 TNF TLR4 IL6 IL4 IFNG CXCL8
42
Show member pathways
12.2 TLR7 TLR4 TLR3 IL5 IL13
43 12.18 TNF TLR4 IL6 IL10 CXCL8
44
Show member pathways
12.17 TNF TLR7 TLR4 TLR3 IL6 IL17A
45 12.14 TNF TLR4 IL6 IL10 IFNG CXCL8
46 12.13 TNF IL6 IL5 IL4R IL4 IL11
47 12.08 TNF IL6 IL4R IL4 IL17A IL13
48
Show member pathways
12.07 TLR7 TLR4 TLR3 IL6 IL4R IL4
49 12.06 IL6 IFNG CXCL8 CCL3
50 12.02 IL6 IL5 IL4 IL13 IFNG CXCL8

GO Terms for Bronchiolitis

Cellular components related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TNF RNASE3 MUC5AC IL6 IL5 IL4R
2 extracellular space GO:0005615 9.55 TNF TLR3 RNASE3 MUC5AC IL6 IL5

Biological processes related to Bronchiolitis according to GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.3 TNF TLR4 TLR3 IL6 IL4 IL17A
2 signal transduction GO:0007165 10.21 TLR7 TLR4 TLR3 RASSF6 IL6 IL5
3 positive regulation of gene expression GO:0010628 10.14 TNF TLR4 TLR3 IL6 IL4 IL13
4 defense response to bacterium GO:0042742 10.1 TNF TLR4 TLR3 RNASE3 IL10
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.08 TNF TLR4 CCL5 CCL3 CCL11
6 positive regulation of cell migration GO:0030335 10.07 IL4 CCL5 CCL3 CCL11
7 defense response to virus GO:0051607 10.06 TLR7 TLR3 IL6 IFNG
8 cellular response to lipopolysaccharide GO:0071222 10.06 TNF TLR4 IL6 IL10 CXCL8
9 chemotaxis GO:0006935 10.04 CXCL8 CCL5 CCL3 CCL11
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 10.03 TNF TLR4 TLR3 IL6
11 cellular response to tumor necrosis factor GO:0071356 10.02 CXCL8 CCL5 CCL3 CCL11
12 positive regulation of DNA-binding transcription factor activity GO:0051091 10.01 TNF IL6 IL5 IL10
13 response to virus GO:0009615 10 TNF TLR3 IFNG CCL5 CCL11
14 cellular response to mechanical stimulus GO:0071260 9.98 TLR7 TLR4 TLR3 IL13
15 cellular response to interferon-gamma GO:0071346 9.98 TLR4 TLR3 CCL5 CCL3 CCL11
16 neutrophil chemotaxis GO:0030593 9.97 CXCL8 CCL5 CCL3 CCL11
17 chemokine-mediated signaling pathway GO:0070098 9.97 CXCL8 CCL5 CCL3 CCL11
18 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.97 TNF TLR7 TLR4 TLR3
19 cellular response to interleukin-1 GO:0071347 9.97 IL17A CXCL8 CCL5 CCL3 CCL11
20 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.96 TNF TLR7 TLR4 TLR3
21 positive regulation of JNK cascade GO:0046330 9.95 TNF TLR4 TLR3
22 positive regulation of smooth muscle cell proliferation GO:0048661 9.95 TNF IL6 IL13 CCL5
23 B cell differentiation GO:0030183 9.94 IL4 IL11 IL10
24 regulation of insulin secretion GO:0050796 9.94 TNF IFNG CCL5
25 cellular response to organic cyclic compound GO:0071407 9.94 TNF CCL5 CCL3
26 apoptotic signaling pathway GO:0097190 9.94 TNF TLR4 TLR3
27 response to glucocorticoid GO:0051384 9.94 TNF IL6 IL10
28 positive regulation of T cell proliferation GO:0042102 9.93 IL6 IL4 CCL5
29 humoral immune response GO:0006959 9.93 TNF IL6 IFNG
30 monocyte chemotaxis GO:0002548 9.93 IL6 CCL5 CCL3 CCL11
31 positive regulation of inflammatory response GO:0050729 9.93 TNF TLR7 TLR4 TLR3 IFNG CCL3
32 inflammatory response GO:0006954 9.93 TNF TLR7 TLR4 TLR3 IL6 IL5
33 positive regulation of tumor necrosis factor production GO:0032760 9.92 TLR4 TLR3 CCL3
34 positive regulation of interleukin-6 secretion GO:2000778 9.92 TNF TLR4 IL17A IFNG
35 extrinsic apoptotic signaling pathway GO:0097191 9.91 TNF TLR3 IFNG
36 toll-like receptor signaling pathway GO:0002224 9.91 TLR7 TLR4 TLR3
37 positive regulation of B cell proliferation GO:0030890 9.91 TLR4 IL5 IL4 IL13
38 positive regulation of interleukin-6 production GO:0032755 9.91 TNF TLR7 TLR4 TLR3 IL6
39 positive regulation of nitric oxide biosynthetic process GO:0045429 9.9 TNF TLR4 IFNG
40 protein kinase B signaling GO:0043491 9.9 TNF CCL5 CCL3
41 lymphocyte chemotaxis GO:0048247 9.9 CCL5 CCL3 CCL11
42 negative regulation of endothelial cell apoptotic process GO:2000352 9.9 IL4 IL13 IL11 IL10
43 negative regulation of interleukin-6 production GO:0032715 9.89 TNF TLR4 IL10
44 positive regulation of cytokine secretion GO:0050715 9.89 TNF IL10 IFNG
45 lipopolysaccharide-mediated signaling pathway GO:0031663 9.89 TNF TLR4 CCL5 CCL3
46 negative regulation of neurogenesis GO:0050768 9.88 TNF IL6 CCL11
47 positive regulation of interleukin-8 production GO:0032757 9.88 TNF TLR7 TLR4 TLR3
48 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 IL4 IL13 IFNG CCL5
49 positive regulation of interleukin-12 production GO:0032735 9.87 TLR4 TLR3 IFNG
50 eosinophil chemotaxis GO:0048245 9.86 CCL5 CCL3 CCL11

Molecular functions related to Bronchiolitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TNF TLR7 TLR4 TLR3 RASSF6 MUC5AC
2 growth factor activity GO:0008083 9.55 IL6 IL5 IL4 IL11 IL10
3 CCR chemokine receptor binding GO:0048020 9.5 CCL5 CCL3 CCL11
4 cytokine activity GO:0005125 9.44 TNF IL6 IL5 IL4 IL17A IL13
5 CCR5 chemokine receptor binding GO:0031730 9.43 CCL5 CCL3
6 phospholipase activator activity GO:0016004 9.4 CCL5 CCL3
7 CCR1 chemokine receptor binding GO:0031726 9.37 CCL5 CCL3
8 chemokine activity GO:0008009 9.26 CXCL8 CCL5 CCL3 CCL11

Sources for Bronchiolitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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