MCID: BRN024
MIFTS: 67

Bronchitis

Categories: Infectious diseases, Respiratory diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Bronchitis

MalaCards integrated aliases for Bronchitis:

Name: Bronchitis 11 2 43 14 63 16 71 75 33
Chronic Bronchitis 11 75 28 41 14 16 33
Acute Bronchitis 11 41 63 71 31 33
Bronchitis, Chronic 75 43 71
Bronchitis Nos in Those Under L5 Years of Age 33
Acute Lower Respiratory Tract Infection 71
Acute Bronchitis and Bronchiolitis 11
Lower Respiratory Tract Infection 71
Recurrent Wheezy Bronchitis 11
Chronic Bronchitis Nos 33
Ci - Chest Infection 11
Bronchitis Chronic 53
Senile Bronchitis 33
Chest Infection 11
Bronchitis Nos 33
Chest Cold 11

Classifications:



Summaries for Bronchitis

MedlinePlus: 41 Bronchitis is an inflammation of the bronchial tubes, the airways that carry air to your lungs. It causes a cough that often brings up mucus. It can also cause shortness of breath, wheezing, a low fever, and chest tightness. There are two main types of bronchitis: acute and chronic. Most cases of acute bronchitis get better within several days. But your cough can last for several weeks after the infection is gone. The same viruses that cause colds and the flu often cause acute bronchitis. These viruses spread through the air when people cough, or though physical contact (for example, on unwashed hands). Being exposed to tobacco smoke, air pollution, dusts, vapors, and fumes can also cause acute bronchitis. Less often, bacteria can also cause acute bronchitis. To diagnose acute bronchitis, your health care provider will ask about your symptoms and listen to your breathing. You may also have other tests. Treatments include rest, fluids, and aspirin (for adults) or acetaminophen to treat fever. A humidifier or steam can also help. You may need inhaled medicine to open your airways if you are wheezing. Antibiotics won't help if the cause is viral. You may get antibiotics if the cause is bacterial. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary: Bronchitis, also known as chronic bronchitis, is related to allergic asthma and haemophilus influenzae, and has symptoms including cough, chest tightness and shortness of breath. An important gene associated with Bronchitis is ELANE (Elastase, Neutrophil Expressed), and among its related pathways/superpathways are Signal Transduction and Innate Immune System. The drugs Cefdinir and Streptokinase have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and t cells, and related phenotypes are immune system and hematopoietic system

PubMed Health : 63 Acute bronchitis: In acute bronchitis, the lower airways (bronchi) are temporarily inflamed. The inflammation is usually caused by cold viruses, so it often occurs together with other symptoms of a cold. Acute bronchitis causes a cough which might not go away for a while, even after the cold has gone away. Although the cough may be unpleasant and persistent, in otherwise healthy people it usually isn’t anything serious. The symptoms then go away on their own after a few weeks. Treatment with medication usually isn’t necessary. Some medications may help relieve the symptoms a bit.

CDC: 2 Bronchitis occurs when the airways of the lungs swell and produce mucus. That's what makes you cough. Acute bronchitis, often called a "chest cold," is the most common type of bronchitis. The symptoms last less than 3 weeks. Antibiotics are not indicated to treat acute bronchitis. Using antibiotics when not needed could do more harm than good. If you're a healthy person without underlying heart or lung problems or a weakened immune system, this information is for you.

Disease Ontology: 11 A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has symptom cough with mucus, has symptom shortness of breath, has symptom low fever and has symptom chest tightness.

Wikipedia: 75 Bronchitis is inflammation of the bronchi (large and medium-sized airways) in the lungs that causes... more...

Related Diseases for Bronchitis

Diseases related to Bronchitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 979)
# Related Disease Score Top Affiliating Genes
1 allergic asthma 32.1 RNASE3 IL9 IL5 CXCL8 CCL11
2 haemophilus influenzae 31.9 TNF LACTB CXCL8
3 common cold 31.7 TNF RNASE3 IL9 IL6 IL5 CXCL8
4 bronchial disease 31.6 TNF RNASE3 IL9 IL6 IL5 ELANE
5 anthracosis 31.5 TNF IL6 CXCL8
6 pulmonary disease, chronic obstructive 31.5 TNF TAC1 SLPI SERPINB1 SERPINA1 RNASE3
7 pulmonary emphysema 31.5 SLPI SERPINB1 SERPINA1 ELANE CXCL8
8 severe combined immunodeficiency 31.5 TNF IL9R IL9 IL6 IL5
9 avian influenza 31.4 TNF IL6 CXCL8
10 hypereosinophilic syndrome 31.4 RNASE3 MPO IL9 IL5 CXCL8 CCL11
11 pneumoconiosis 31.4 TNF SERPINA1 IL6 CXCL8
12 chronic rhinitis 31.2 TAC1 RNASE3 IL5
13 bronchiectasis 31.2 TNF SLPI SERPINA1 MPO IL6 ELANE
14 tracheitis 31.1 TNF IL6 CXCL8 CRP
15 chlamydia 31.1 TNF IL6 IL5 CXCL8 CRP
16 bronchiolitis 31.1 TNF RNASE3 IL9 IL6 IL5 CXCL8
17 respiratory failure 31.1 TNF TAC1 SERPINA1 RNASE3 MPO IL6
18 childhood-onset asthma 31.0 RNASE3 IL5 CCL11
19 aspergillosis 31.0 TNF SLPI IL6 IL5 ELANE CXCL8
20 cough variant asthma 31.0 TAC1 RNASE3 IL5
21 bronchopneumonia 30.9 TNF MPO IL6 ELANE CXCL8 CRP
22 neutrophilia, hereditary 30.9 MPO IL6 CRP
23 farmer's lung 30.9 TNF SLPI ELANE
24 severe acute respiratory syndrome 30.9 TNF IL6 CXCL8 CRP
25 occupational asthma 30.9 RNASE3 IL5 CXCL8 CCL11
26 laryngitis 30.9 TNF IL6 CXCL8 CRP
27 exanthem 30.9 TNF MPO IL6 CXCL8 CRP
28 pulmonary hypertension 30.9 VIP TNF SERPINA1 IL6 ELANE CRP
29 rhinitis 30.8 VIP TNF RNASE3 IL9 IL6 IL5
30 lung disease 30.8 TNF SLPI SERPINB1 SERPINA1 RNASE3 MPO
31 extrinsic allergic alveolitis 30.8 TNF ELANE CXCL8
32 bronchiolitis obliterans 30.8 TNF MPO IL6 CXCL8 CRP
33 gastroenteritis 30.8 TNF RNASE3 LACTB IL6 IL5 CXCL8
34 sickle cell anemia 30.8 TNF IL6 CRP CFTR
35 eosinophilic pneumonia 30.8 RNASE3 IL5 CXCL8 CCL11
36 mycoplasma pneumoniae pneumonia 30.7 TNF IL6 CXCL8 CRP
37 angina pectoris 30.7 TNF IL6 CRP
38 status asthmaticus 30.7 RNASE3 IL5 ELANE CXCL8 CCL11
39 dermatitis 30.7 TNF RNASE3 IL6 IL5 CXCL8 CCL11
40 pharyngitis 30.7 TNF LACTB IL6 CXCL8 CRP
41 exercise-induced bronchoconstriction 30.7 RNASE3 IL5 CXCL8
42 tonsillitis 30.7 TNF MPO LACTB IL6 CXCL8
43 proteasome-associated autoinflammatory syndrome 1 30.6 TNF RNASE3 MPO IL6 IL5 ELANE
44 lung abscess 30.6 TNF LACTB IL6 CRP
45 adult syndrome 30.6 TNF IL6 CRP
46 croup 30.6 IL6 CXCL8 CRP
47 gastroesophageal reflux 30.6 VIP TNF SLPI MPO IL6 IL5
48 candidiasis 30.6 TNF IL6 IL5 CXCL8
49 invasive aspergillosis 30.6 TNF IL6 CRP
50 bacterial pneumonia 30.6 TNF MPO LACTB IL6 ELANE CXCL8

Comorbidity relations with Bronchitis via Phenotypic Disease Network (PDN): (show top 50) (show all 127)


Acquired Polycythemia Active Peptic Ulcer Disease
Acute Conjunctivitis Acute Cor Pulmonale
Acute Cystitis Acute Ethmoiditis
Acute Frontal Sinusitis Acute Kidney Failure
Acute Maxillary Sinusitis Agammaglobulinemia, X-Linked
Allergic Rhinitis Alzheimer Disease, Familial, 1
Anthracosis Anxiety
Aortic Valve Disease 1 Asbestosis
Aspergillosis Asthma
Atrophic Gastritis Benign Essential Hypertension
Bronchiectasis Bronchopneumonia
Cardiac Arrest Cerebral Atherosclerosis
Cerebral Degeneration Cerebrovascular Disease
Chronic Ethmoiditis Chronic Frontal Sinusitis
Chronic Kidney Disease Chronic Laryngitis
Chronic Maxillary Sinusitis Chronic Pulmonary Heart Disease
Chronic Rhinitis Conjunctivitis
Conn's Syndrome Cystitis
Decubitus Ulcer Deficiency Anemia
Diabetic Polyneuropathy Diaphragm Disease
Duodenitis Dyskinesia of Esophagus
Dysthymic Disorder Encephalopathy
Esophageal Candidiasis Esophageal Disease
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Gastroesophageal Reflux

Graphical network of the top 20 diseases related to Bronchitis:



Diseases related to Bronchitis

Symptoms & Phenotypes for Bronchitis

Symptoms:

11
  • cough
  • chest tightness
  • shortness of breath
  • low fever

UMLS symptoms related to Bronchitis:


fever; recurrent pharyngitis; pruritus; snoring; coughing

GenomeRNAi Phenotypes related to Bronchitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.18 CCL11 CFTR CRP CXCL8 DDX1 ELANE
2 no effect GR00402-S-2 10.18 CCL11 CFTR CRP DDX1 ELANE IL5

MGI Mouse Phenotypes related to Bronchitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.77 CCL11 CFTR CRP ELANE IL5 IL6
2 hematopoietic system MP:0005397 9.4 CCL11 CFTR ELANE IL5 IL6 IL9

Drugs & Therapeutics for Bronchitis

PubMed Health treatment related to Bronchitis: 63

Acute bronchitis gets better on its own without treatment . If you feel weak and ill, it’s best to take it easy for a few days. This also means not doing any sports or other strenuous physical activities. Hot tea or broth is usually considered to have a soothing effect. But there is no scientific proof that drinking a lot more fluids than usual helps, or doesn’t help. Acute bronchitis doesn’t need to be treated with medication. Drugs such as paracetamol (acetaminophen ) or ibuprofen are sometimes a good idea, though, for the relief of cold symptoms such as fever and pain. There hasn’t been enough research on the effectiveness of cough medicines that are designed to make you cough less (cough suppressants) or make it easier to cough up phlegm (expectorants). Because coughing has the important function of getting rid of mucus and foreign objects, cough suppressants should only be used for a limited amount of time, and only for really unpleasant, dry coughs that disrupt your sleep . Herbal medicines might relieve coughs somewhat. Because the symptoms are usually caused by viruses , antibiotics don’t help much in the treatment of acute bronchitis . But they can have side effects and contribute to bacteria becoming resistant. So antibiotics aren’t recommended as a treatment for acute bronchitis.

Drugs for Bronchitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefdinir Approved Phase 4 91832-40-5 6915944
2
Streptokinase Approved, Investigational Phase 4 9002-01-1
3
Tiotropium Approved Phase 4 136310-93-5, 186691-13-4 3086655 5487427 5487426
4
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
5
Ofloxacin Approved Phase 4 82419-36-1 4583
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Clavulanic acid Approved, Vet_approved Phase 4 58001-44-8 5280980
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Ethinylestradiol Approved Phase 4 57-63-6 5991
10
Polyestradiol phosphate Approved Phase 4 28014-46-2
11
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
12
Moxifloxacin Approved, Investigational Phase 4 186826-86-8, 354812-41-2, 151096-09-2 152946
13
Cefuroxime Approved Phase 4 55268-75-2 5479529
14
Cathine Approved, Experimental, Illicit, Vet_approved, Withdrawn Phase 4 14838-15-4, 492-39-7 131954576 4786 26934
15
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
16
Ipratropium Approved, Experimental Phase 4 22254-24-6, 60205-81-4 657309 3746
17
Thyme Approved Phase 4
18
Codeine Approved, Illicit Phase 4 76-57-3, 6854-40-6 5284371 5362471
19
Dextromethorphan Approved Phase 4 125-71-3 5362449 5360696
20
Racephedrine Approved, Experimental Phase 4 299-42-3, 90-82-4, 90-81-3 5032 9294 7028
21
Chlorpheniramine Approved Phase 4 113-92-8, 132-22-9 2725
22
Aluminium phosphate Approved, Investigational Phase 4 7784-30-7
23
Montelukast Approved Phase 4 158966-92-8 5281040
24
Acetylcysteine Approved, Investigational Phase 4 616-91-1 581 12035
25
Losartan Approved Phase 4 114798-26-4 3961
26
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
27
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
28
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
29
Cysteine Approved, Nutraceutical Phase 4 52-90-4 594 5862
30
Andrographolide Investigational Phase 4 5508-58-7 343585
31
Bambuterol Investigational Phase 4 81732-65-2, 81732-46-9 54766
32 Antibiotics, Antitubercular Phase 4
33 Platelet Aggregation Inhibitors Phase 4
34 Andrographis Phase 4
35 Vitamins Phase 4
36 Calciferol Phase 4
37 Calcium, Dietary Phase 4
38 Antipyretics Phase 4
39
Vitamin D2 Phase 4 3249
40 Ergocalciferols Phase 4
41 Antitussive Agents Phase 4
42 Parasympatholytics Phase 4
43 Bromides Phase 4
44 Anticonvulsants Phase 4
45 Anti-Inflammatory Agents Phase 4
46 Cholinergic Antagonists Phase 4
47 Cholinergic Agents Phase 4
48 Amoxicillin-Potassium Clavulanate Combination Phase 4
49 beta-Lactamase Inhibitors Phase 4
50 Estradiol 3-benzoate Phase 4

Interventional clinical trials:

(show top 50) (show all 311)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Combined With Andrographolide Sulfonate on the Basis of Conventional Therapy in Patients With Acute Exacerbation of Chronic Bronchitis: a Randomized, Single Blind, Placebo-controlled, Multicenter Study Unknown status NCT03132610 Phase 4 andrographolide sulfonate;andrographolide sulfonate simulation
2 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Treatment of Acute Exacerbation of Chronic Bronchitis (AECB) and Community-acquired Pneumonia (CAP) in Adults Unknown status NCT03400735 Phase 4 Cefdinir 300Mg Capsule
3 Effects of Exercise Training on Systemic Inflammation an Muscle Repair According to the Chronic Obstructive Pulmonary Disease Phenotype Unknown status NCT01431625 Phase 4
4 Inspiratory Capacity and HRCT Comparison of Nebulized Arformoterol (Brovana) vs. Dry-powder Inhaler Salmeterol (Serevent) Unknown status NCT01361984 Phase 4 Nebulized arformoterol;Salmeterol
5 Randomised, Open-label, Parallel-group Study of the Response to Bronchodilator Treatment in Subjects With Eosinophilic Bronchitis and the Mechanism of Varied Responses to Bronchodilator Treatment. Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
6 Double-blind, Randomized, Placebo Controlled, Multicenter, Phase IV Clinical Trial to Assess the Efficacy and Safety of MUCOLASE Tablet (Streptokinase • Streptodornase) in Patients With Acute Upper Respiratory Infection or Acute Bronchitis Unknown status NCT04252963 Phase 4 MUCOLASE tablet (streptokinase • streptodornase);Placebo
7 Randomized Double-blind Placebo-controlled Study of add-on Montelukast to Inhaled Budesonide in the Treatment of Nonasthmatic Eosinophilic Bronchitis Unknown status NCT01121016 Phase 4 Montelukast
8 The Efficacy and Safety of Andrographolide Sulfonate in the Treatment of Acute Bronchitis: a Randomized,Double-blind,Placebo Parallel Controlled,Multicenter Study Unknown status NCT03132623 Phase 4 andrographolide sulfonate;andrographolide sulfonate simulation
9 A Multicenter, Randomized, Open Label, Add-on Study to Assess Efficacy and Safety of Xiyanping Injection in Subjects With Pediatric Bronchitis Unknown status NCT02937857 Phase 4 Standard treatment only;Standard treatment+Xiyanping injection
10 Effect of Vitamin D Supplementation in Young Children With Acute Lower Respiratory Tract Infection at Dr George Mukhari Academic Hospital, Pretoria, South Africa Unknown status NCT02054182 Phase 4 Vitamin D
11 The Norwegian Antibiotics for Pneumonia in Children Study Unknown status NCT03446534 Phase 4 Amoxicillin;Placebos
12 Efficacy of Intermittent Tiotropium in Early Childhood Wheezing Completed NCT03199976 Phase 4 Tiotropium Bromide;Fluticasone Propionate;Salbutamol
13 The Effectiveness of Roflumilast in Improving Mucociliary Clearance in Patients With COPD and Chronic Bronchitis Completed NCT03073798 Phase 4 Roflumilast;Placebo
14 MAESTRAL - A Prospective, Multinational, Multicenter, Randomized, Double Blind, Double Dummy, Controlled Study Comparing the Efficacy and Safety of Moxifloxacin to That of Amoxicillin Clavulanic Acid for the Treatment of Subjects With Acute Exacerbations of Chronic Bronchitis. Completed NCT00656747 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Amoxicillin clavulanic acid
15 Efficacy of Losartan in Preventing Progression of COPD Completed NCT00720226 Phase 4 Losartan;Placebo
16 Randomised Cross-over Study to Compare the Effect of Formoterol Plus Tiotropium Versus Formoterol Monotherapy on Breathlessness, Dynamic Hyperinflation and Exercise Tolerance in Moderate-to-severe Stable COPD Patients Completed NCT00680056 Phase 4 Formoterol plus Placebo (Tiotropium);Formoterol plus Tiotropium
17 A Canadian Multicenter, Prospective, Open Label, Non-Comparative Study of the Effectiveness and Safety of Oral Telithromycin, 800mg Once Daily in the Treatment of Either Community Acquired Pneumonia or Acute Exacerbation of Chronic Bronchitis in Ambulator Completed NCT00546676 Phase 4 Telithromycin
18 A Multicenter, Multinational, Randomized, DB Controlled Study of the Efficacy & Safety of Oral Telithromycin 800 mg Once QD for 5 Days vs Azithromycin in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adult Outpatients With COPD. Completed NCT00538148 Phase 4 Telithromycin
19 An Open-label, Randomized, Multicenter, Clinical Study to Compare the Effects of Telithromycin, Azithromycin and Cefuroxime Axetil on the Penicillin or Macrolide Resistance of Streptococcus Pneumoniae in Patients With Acute Exacerbation of Chronic Bronchitis Completed NCT00132938 Phase 4 telithromycin
20 Study Regarding the Clinical Efficacy of Synatura® in Patients With Chronic Bronchitis Type COPD Completed NCT03623282 Phase 4 Synatura® 15 mL
21 A Double-blind Placebo-controlled Trial Comparing the Efficacy and Cost-effectiveness of Inhaled Fluticason Propionate Versus Oral N-acetylcysteine in the Treatment of Patients With COPD in General Practice Completed NCT00184977 Phase 4 N-acetylcysteine;fluticasone propionate
22 A Randomized, Sham-controlled, Double-blinded Pilot Study to Assess the Effects of High Frequency Chest Wall Oscillation (HFCWO) Therapy in Patients With Chronic Bronchitis Completed NCT00181207 Phase 4
23 A Double-blind, Placebo Controlled, Randomized Crossover Trial to Characterize the Mucolytic Effectiveness of Tacholiquine® in Chronic Bronchitis Completed NCT02515799 Phase 4 Tacholiquine
24 Effects of Fluticasone On Systemic Markers of Inflammation in Chronic Obstructive Pulmonary Disease Completed NCT00175565 Phase 4 inhaled fluticasone 500 mcg b.i.d.
25 Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB). Multi-centre, Open-label, Randomised, Pilot Study to Evaluate the Effects of the Treatment on Serum Inflammatory Biomarkers Completed NCT01467297 Phase 4 ceftidoren;levofloxacin
26 Effectiveness of Antitussives, Anticholinergics and Honey Versus Usual Care in Adults With Uncomplicated Acute Bronchitis. Completed NCT03738917 Phase 4 Dextromethorphan 15 milligrams;Ipratropium Bromide 20Micrograms Inhaler
27 Randomised, Open-label, Parallel-group Study of Therapeutic Effect of Different Treatment Course With Inhaled Corticosteroids in Eosinophilic Bronchitis Patients Completed NCT02002715 Phase 4 Inhaled budesonide
28 A Prospective, Open-label Study of Azithromycin for Lymphocytic Bronchiolitis/Bronchitis After Lung Transplantation Completed NCT01109160 Phase 4 Azithromycin Dihydrate
29 A Randomized, Double-Blind, Parallel-Group, Multicenter, Placebo-Controlled Study of the Safety and Efficacy of Mucinex D as Adjunct Therapy to Antibiotic Treatment of Acute Respiratory Infection Completed NCT00441246 Phase 4 Mucinex D (600 mg guaifenesin and 60 mg pseudoephedrine HCl extended-release bi-layer tablets)
30 A Two-Week, Randomized, Modified-Blind, Double-Dummy, Parallel-Group Efficacy and Safety Study of Arformoterol Tartrate Inhalation Solution Twice-Daily, Tiotropium Once-Daily, and Arformoterol Tartrate Inhalation Solution Twice-Daily and Tiotropium Once Daily in Subjects With Chronic Obstructive Pulmonary Disease Completed NCT00424528 Phase 4 Arformoterol Tartrate Inhalation Solution;Tiotropium;Arformoterol and Tiotropium;Placebo
31 Phase 4 Study of Oral Montelukast Hospitalized Preschool Children Completed NCT03369119 Phase 4 Montelukast 4 Mg Oral Granule;Placebos
32 Clinical Trial for the Assessment of Delayed Antibiotic Treatment in the Non-complicated Acute Respiratory Tract Infections in Pediatric (Study DAP-Pediatrics) Completed NCT01800747 Phase 4
33 Clinical Trial for the Assessment of Delayed Antibiotic Treatment Strategies in the Non-complicated Acute Respiratory Tract Infections in General Practice Completed NCT01363531 Phase 4
34 Clinical Evaluation of a Meropenem Dosage Strategy Based on a Population Pharmacokinetic-pharmacodynamic Model in Lower Respiratory Tract Infection Patients Completed NCT01944319 Phase 4 Routine meropenem therapy;Meropenem therapy based on a PPK and PD model
35 Pneumococcal Conjugate Vaccine (PCV) Schedules for the Northern Territory (NT): Randomised Controlled Trial of Booster Vaccines to Broaden and Strengthen Protection From Invasive and Mucosal Infections. Completed NCT01735084 Phase 4
36 Anti-inflammatory Effects of Macrolide Treatment in Influenza Lower Respiratory Tract Infections Completed NCT01779570 Phase 4 Macrolide treatment
37 Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Elderly People With Chronic Bronchitis and Chronic Obstructive Pulmonary Disease Recruiting NCT05075083 Phase 4
38 Immunogenicity and Safety of an Inactivated COVID-19 Vaccine in Patients Aged ≥60 Years With Chronic Bronchitis and Chronic Obstructive Pulmonary Disease Recruiting NCT05075057 Phase 4
39 Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases Recruiting NCT04765722 Phase 4 Mepolizumab;Normal Saline
40 Effectiveness of Montelukast in Children With Recurrent Obstructive Bronchitis Active, not recruiting NCT04613180 Phase 4 Montelukast Sodium;Placebo
41 Effect of Zhuli Capsule on Phlegm-heat Syndrome (Tan-re Zheng) in the Acute Exacerbations of Chronic Obstructive Pulmonary Disease or Chronic Bronchitis Not yet recruiting NCT04834531 Phase 4 Zhuli capsule;Placebo
42 Immunogenicity and Safety of a Third Dose and Immune Persistence of BBIBP-Corv Vaccine in Elderly People With Chronic Bronchitis and Chronic Obstructive Pulmonary Disease Not yet recruiting NCT05104216 Phase 4
43 A Randomized, Double Blind, Placebo Controlled Trial of Intravenous N-acetylcysteine and Oseltamivir Versus Intravenous 5% Dextrose and Oseltamivir in Adults Hospitalized With Influenza Complicated by Lower Respiratory Tract Infection. Not yet recruiting NCT03900988 Phase 4 N-acetyl cysteine;5% Dextrose
44 A Randomized, Investigator Blinded, Multi-Center Clinical Study To Compare Patient Outcomes and Clinical Effectiveness of Telithromycin Versus Azithromycin in Outpatients With Lower Respiratory Tract Infections Terminated NCT00132951 Phase 4 Telithromycin;Azithromycin
45 Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis Terminated NCT02416102 Phase 4 Losartan 50 mg;Losartan 100 mg
46 Multicenter Non Comparative Phase IV Study on the Safety and Efficacy of Telithromycin 800 mg Per Day for 5 Days in the Treatment of Acute Exacerbation of Chronic Bronchitis in Adults Terminated NCT00288223 Phase 4 Telithromycin
47 Perforomist Versus Foradil Evaluated by Inspiratory Capacity and HRCT Withdrawn NCT00633776 Phase 4 formoterol fumarate
48 An Open Label Study to Investigate the Role of Ivacaftor (VX-770) for the Treatment of Chronic Bronchitis With CFTR Dysfunction Withdrawn NCT03251911 Phase 4 Ivacaftor (VX-770)
49 Randomized Aseptic Pharmacokinetic Pharmacodynamic Outpatient Registry Trial of Respiratory Tract Infections in Adults (RAPPORT) Withdrawn NCT00245453 Phase 4 azithromycin;telithromycin;Clarythromycin
50 A Multi-center, Randomized, Double-blind, Double-dummy Clinical Study to Evaluate the Safety and Efficacy of Prulifloxacin Film-coated Tablet for the Treatment of Acute Exacerbations of Chronic Bronchitis With Levofloxacin Hydrochloride Tablet as Active Control Unknown status NCT02157571 Phase 3 Prulifloxacin;Levofloxacin;Levofloxacin Placebo;Prulifloxacin placebo

Search NIH Clinical Center for Bronchitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Acetylcysteine
Aminophylline
aminophylline dihydrate
AMINOPHYLLINE PWDR
cefditoren
CEFTIBUTEN DIHYDRATE
Dornase Alfa
fenugreek seed meal
Fenugreek seed preparation
FENUGREEK SEED PWDR
gemifloxacin mesylate
Guaifenesin
iodinated glycerol
Ipratropium
Ipratropium Bromide
lomefloxacin
oxtriphylline
Theophylline
Theophylline anhydrous
Theophylline calcium salicylate
Theophylline Sodium Glycinate
TRIMETHOPRIM SULFATE

Cochrane evidence based reviews: bronchitis

Genetic Tests for Bronchitis

Genetic tests related to Bronchitis:

# Genetic test Affiliating Genes
1 Chronic Bronchitis 28

Anatomical Context for Bronchitis

Organs/tissues related to Bronchitis:

MalaCards : Lung, Heart, T Cells, Bone Marrow, Trachea, Neutrophil, Liver

Publications for Bronchitis

Articles related to Bronchitis:

(show top 50) (show all 23722)
# Title Authors PMID Year
1
Ivy leaves extract EA 575 in the treatment of cough during acute respiratory tract infections: meta-analysis of double-blind, randomized, placebo-controlled trials. 62 41
36414647 2022
2
Social Inequalities: Do They Matter in Asthma, Bronchitis, and Respiratory Symptoms in Children? 62 41
36430088 2022
3
Respiratory health among adolescents living in the Highveld Air Pollution Priority Area in South Africa. 62 41
36411414 2022
4
A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy. 62 41
36376327 2022
5
Chronic rhinosinusitis associated with chronic bronchitis in a five-year follow-up: the Telemark study. 62 41
36348489 2022
6
Chronic obstructive pulmonary disease phenotypes in Turkey: the COPET study-a national, multicenter cross-sectional observational study. 62 41
36326395 2022
7
Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality risk. 53 62
19581277 2009
8
Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. 53 62
17573447 2007
9
Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. 53 62
17389752 2007
10
Plasma cells and IL-4 in chronic bronchitis and chronic obstructive pulmonary disease. 53 62
17322111 2007
11
[Systemic and lung inflammation in 2 phenotypes of chronic obstructive pulmonary disease]. 53 62
16945263 2006
12
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. 53 62
16497995 2006
13
High seroprevalence of Helicobacter pylori in chronic bronchitis among Chinese population. 53 62
16565595 2006
14
ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure. 53 62
15923396 2005
15
[Complex search for antiprotease-protease enzyme gene polymorphisms in patients with chronic obstructive pulmonary diseases]. 53 62
15612581 2004
16
Enhanced PMN response in chronic bronchitis and community-acquired pneumonia. 53 62
15516671 2004
17
[Protective and therapeutic effect of pulmonary surfactant on the experimental chronic obstructive pulmonary disease in hamsters]. 53 62
15266830 2004
18
Atypical sinusitis in adults must lead to looking for cystic fibrosis and primary ciliary dyskinesia. 53 62
15126740 2004
19
Marked up-regulation of T lymphocytes and expression of interleukin-9 in bronchial biopsies from patients With chronic bronchitis with obstruction. 53 62
14605067 2003
20
Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents. 53 62
12789686 2003
21
The role of neural inflammation in asthma and chronic obstructive pulmonary disease. 53 62
12794061 2003
22
[The study of inflammatory mediators and pulmonary ventilatory capacity in patients with chronic obstructive pulmonary disease]. 53 62
12775264 2003
23
[Eotaxin in induced sputum in patients with asthma and chronic bronchitis: relationship with airway inflammation]. 53 62
11953096 2002
24
Eotaxin and CCR3 are up-regulated in exacerbations of chronic bronchitis. 53 62
11991282 2002
25
Mucin-producing elements and inflammatory cells. 53 62
12568488 2002
26
Interleukin-4 and interleukin-5 gene expression and inflammation in the mucus-secreting glands and subepithelial tissue of smokers with chronic bronchitis. Lack of relationship with CD8(+) cells. 53 62
11751191 2001
27
Pre-protachykinin-A mRNA is increased in the airway epithelium of smokers with chronic bronchitis. 53 62
11555376 2001
28
Bacteriology and beta-lactamase activity in acute exacerbation of chronic bronchitis. 53 62
11468101 2001
29
[Effects of bacterial extract IRS-19 on the concentration of hydrogen peroxide and myeloperoxidase activity in nasal washings of patients with chronic bronchitis]. 53 62
11417179 2001
30
Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction. 53 62
10917466 2000
31
Airways inflammation in chronic bronchitis: the effects of smoking and alpha1-antitrypsin deficiency. 53 62
10853853 2000
32
Heat shock proteins mRNA expressions by peripheral blood mononuclear cells in asthma and chronic bronchitis. 53 62
11775547 2000
33
Detection of CFTR gene mutations in patients suffering from chronic bronchitis. 53 62
10767489 2000
34
IL-9 and its receptor in allergic and nonallergic lung disease: increased expression in asthma. 53 62
10629460 2000
35
Pancreatitis and cystic fibrosis gene mutations. 53 62
10503135 1999
36
The significance of sputum ECP levels in differential diagnosis of asthma in children. 53 62
10498044 1999
37
Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). 53 62
9920411 1998
38
Complete mutational screening of the CFTR gene in 120 patients with pulmonary disease. 53 62
9921909 1998
39
Environmental correlates of impaired lung function in non-smokers with severe alpha 1-antitrypsin deficiency (PiZZ). 53 62
10193391 1998
40
Cellular and molecular characteristics of inflammation in chronic bronchitis. 53 62
9650009 1998
41
Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients. 53 62
9476865 1998
42
Blood interleukin-8 production is increased in chemical workers with bronchitic symptoms. 53 62
9358925 1997
43
Increased VIP-positive nerve fibers in the mucous glands of subjects with chronic bronchitis. 53 62
9412581 1997
44
Human lactoferrin receptor activity in non-encapsulated Haemophilus influenzae. 53 62
9368377 1997
45
Biochemical and pharmacological characterization of FK706, a novel elastase inhibitor. 53 62
9389382 1997
46
Iron-binding proteins in sputum of chronic bronchitis patients with Haemophilus influenzae infections. 53 62
9387961 1997
47
Serum secretory leukoprotease inhibitor levels in chronic bronchitis and Sjögren's syndrome. 53 62
9352624 1997
48
Inhibition of neutrophil elastase-induced interleukin-8 gene expression by urinary trypsin inhibitor in human bronchial epithelial cells. 53 62
9030096 1997
49
Effect of bacterial extract, IRS-19, on the concentration of hydrogen peroxide and myeloperoxidase activity in nasal washings of patients with chronic bronchitis. 53 62
9090443 1997
50
[Interleukin-6 and interleukin-8 in bronchoalveolar lavage fluid material from patients with chronic bronchitis]. 53 62
9273226 1996

Variations for Bronchitis

Expression for Bronchitis

Search GEO for disease gene expression data for Bronchitis.

Pathways for Bronchitis

Pathways related to Bronchitis according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1 13.73 VIP TNF TMPO TAC1 IL6 IL5
2
Show member pathways
13.66 CCL11 CRP CXCL8 ELANE IL5 IL6
3
Show member pathways
13.36 TNF IL9R IL9 IL6 IL5 CXCL8
4
Show member pathways
13.24 TNF IL9R IL9 IL6 IL5 CXCL8
5
Show member pathways
13.21 TNF IL9R IL9 IL6 IL5 CXCL8
6
Show member pathways
12.54 TNF IL9R IL9 IL6 IL5 CXCL8
7
Show member pathways
12.25 TNF IL6 CXCL8 CFTR CCL11
8
Show member pathways
12.19 TNF IL6 CXCL8 CFTR
9 12.07 CXCL8 IL6 TAC1 TNF
10 11.89 TNF MPO IL6 IL5
11
Show member pathways
11.82 IL6 CXCL8 CFTR
12 11.81 TNF IL5 CXCL8
13 11.81 TNF IL6 CXCL8 CCL11
14 11.74 TNF IL9 IL5
15
Show member pathways
11.71 IL6 CXCL8 CRP
16 11.71 IL6 IL5 CXCL8
17 11.69 TNF IL6 CXCL8
18 11.66 TNF IL6 CRP
19 11.65 CXCL8 IL5 IL6
20
Show member pathways
11.63 TNF IL5 CXCL8
21
Show member pathways
11.6 TNF IL6 CXCL8
22
Show member pathways
11.56 TNF IL6 IL5
23 11.53 CXCL8 ELANE IL6 TNF
24 11.48 TNF IL6 CXCL8
25 11.43 TNF IL6 CXCL8
26 11.41 IL9 IL5 CCL11
27 11.21 TNF IL9 IL6 IL5
28 11.19 TNF IL6 CXCL8
29 11.15 TNF IL6 IL5
30 11.12 TNF IL6 CXCL8
31 11.05 TNF IL6 IL5 CXCL8
32 10.93 TNF IL9 IL6 IL5 CXCL8 CCL11
33 10.9 TNF SERPINA1 IL6 IL5 CXCL8 CCL11
34 10.74 TNF IL6 CXCL8 CRP
35 10.65 IL6 CXCL8
36 10.34 IL9R IL9 IL6 IL5
37
Show member pathways
10.24 TNF IL6 CXCL8

GO Terms for Bronchitis

Cellular components related to Bronchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.15 CCL11 CRP CXCL8 ELANE IL5 IL6
2 extracellular space GO:0005615 9.8 CCL11 CRP CXCL8 ELANE IL5 IL6

Biological processes related to Bronchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.06 TNF RNASE3 IL6 CRP
2 acute-phase response GO:0006953 9.91 SERPINA1 IL6 CRP
3 defense response to bacterium GO:0042742 9.91 TNF SLPI RNASE3 MPO ELANE
4 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 9.88 TNF IL6 IL5
5 immune response GO:0006955 9.81 TNF SLPI IL9 IL6 IL5 CXCL8
6 negative regulation of neurogenesis GO:0050768 9.8 TNF IL6 CCL11
7 response to gold nanoparticle GO:1990268 9.56 MPO TNF
8 inflammatory response GO:0006954 9.53 TNF TAC1 IL9 IL6 IL5 CXCL8
9 negative regulation of lipid storage GO:0010888 9.43 TNF IL6 CRP

Molecular functions related to Bronchitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.32 TNF IL9 IL6 IL5 CXCL8 CCL11

Sources for Bronchitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....