MCID: BRN133
MIFTS: 28

Bronchomalacia

Categories: Fetal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchomalacia

MalaCards integrated aliases for Bronchomalacia:

Name: Bronchomalacia 57 29 73
Williams-Campbell Syndrome 57 59
Tracheobronchomalacia 73

Characteristics:

Orphanet epidemiological data:

59
williams-campbell syndrome
Inheritance: Not applicable;

Classifications:



External Ids:

OMIM 57 211450
Orphanet 59 ORPHA411501
UMLS via Orphanet 74 C0340231
ICD10 via Orphanet 34 Q33.4
MedGen 42 C0264353

Summaries for Bronchomalacia

MalaCards based summary : Bronchomalacia, also known as williams-campbell syndrome, is related to chitayat syndrome and tracheomalacia. An important gene associated with Bronchomalacia is ERF (ETS2 Repressor Factor). Affiliated tissues include trachea, lung and heart.

Wikipedia : 76 Bronchomalacia is a term for weak cartilage in the walls of the bronchial tubes, often occurring in... more...

Description from OMIM: 211450

Related Diseases for Bronchomalacia

Diseases related to Bronchomalacia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 chitayat syndrome 12.0
2 tracheomalacia 10.5
3 bronchiectasis 10.4
4 respiratory failure 10.2
5 laryngomalacia 10.1
6 asthma 10.1
7 bunion 10.1
8 total anomalous pulmonary venous return 1 9.9
9 larsen syndrome 9.9
10 pancreas, annular 9.9
11 pectus excavatum 9.9
12 digeorge syndrome 9.9
13 vater/vacterl association 9.9
14 cystic fibrosis 9.9
15 patent ductus arteriosus 1 9.9
16 spondylocostal dysostosis 3, autosomal recessive 9.9
17 bronchiolitis obliterans 9.9
18 pulmonary emphysema 9.9
19 vacterl association 9.9
20 ventricular septal defect 9.9
21 dysostosis 9.9
22 bronchiolitis 9.9
23 pneumonia 9.9
24 polyhydramnios 9.9
25 bronchogenic cyst 9.9
26 cystic adenomatoid malformation of lung 9.9

Graphical network of the top 20 diseases related to Bronchomalacia:



Diseases related to Bronchomalacia

Symptoms & Phenotypes for Bronchomalacia

Clinical features from OMIM:

211450

Drugs & Therapeutics for Bronchomalacia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Airway Pressure and Lumen Changes During NIV With Flexible Bronchoscopy Completed NCT03666403 Not Applicable
2 Mapping Sound Propagation Through the Human Lung for Better Diagnosis Recruiting NCT03043898

Search NIH Clinical Center for Bronchomalacia

Genetic Tests for Bronchomalacia

Genetic tests related to Bronchomalacia:

# Genetic test Affiliating Genes
1 Bronchomalacia 29

Anatomical Context for Bronchomalacia

MalaCards organs/tissues related to Bronchomalacia:

41
Trachea, Lung, Heart, Pancreas

Publications for Bronchomalacia

Articles related to Bronchomalacia:

(show top 50) (show all 92)
# Title Authors Year
1
Descending Aortopexy and Posterior Tracheopexy for Severe Tracheomalacia and Left Mainstem Bronchomalacia. ( 29524603 )
2018
2
Dynamic expiratory CT: An effective non-invasive diagnostic exam for fragile children with suspected tracheo-bronchomalacia. ( 29148213 )
2018
3
Bronchoscopic assessments and clinical outcomes in pediatric patients with tracheomalacia and bronchomalacia. ( 29124401 )
2018
4
Laryngomalacia, Tracheomalacia and Bronchomalacia. ( 29622320 )
2018
5
Chitayat syndrome: hyperphalangism, characteristic facies, hallux valgus and bronchomalacia results from a recurrent c.266A>G p.(Tyr89Cys) variant in the ERF gene. ( 27738187 )
2017
6
Combined use of Neurally Adjusted Ventilatory Assist (NAVA) and Vertical Expandable Prostethic Titanium Rib (VEPTR) in a patient with Spondylocostal dysostosis and associated bronchomalacia. ( 28196820 )
2017
7
A Case of the TOF with APV Complicated with Polyhydramnios and Severe Bronchomalacia. ( 27579200 )
2016
8
Severe Pediatric Bronchomalacia. ( 26682632 )
2016
9
Direct Tracheobronchopexy and Posterior Descending Aortopexy for Severe Left Mainstem Bronchomalacia Associated With Congenital Pulmonary Airway Malformation and Left Circumflex Aortic Arch. ( 27343517 )
2016
10
Annular Pancreas, Severe Tracheomalacia and Bronchomalacia in a Preterm Boy with Vacterl Association. ( 29485824 )
2016
11
Isolated severe bilateral bronchomalacia: authors' reply. ( 25338493 )
2015
12
Isolated severe bilateral bronchomalacia: correspondence. ( 25371143 )
2015
13
Late-onset Pompe disease with left-sided bronchomalacia. ( 25316892 )
2015
14
Oki stenting for anastomotic bronchomalacia in lung transplantation. ( 26003956 )
2015
15
The Clinical Manifestations, Diagnosis and Management of Williams-Campbell Syndrome. ( 25317385 )
2014
16
An asthmatic patient with bronchomalacia and good response with continuous positive airway pressure. ( 24139329 )
2014
17
Bronchial stent placement in a dog with bronchomalacia and left atrial enlargement. ( 24506740 )
2014
18
Isolated severe bilateral bronchomalacia. ( 23715795 )
2014
19
Clinical evaluation and endoscopic classification of bronchomalacia in dogs. ( 23647392 )
2013
20
Williams-Campbell syndrome: a case report. ( 22287845 )
2012
21
Canine bronchomalacia: a clinicopathological study of 18 cases diagnosed by endoscopy. ( 21177126 )
2012
22
Bronchomalacia in dogs with myxomatous mitral valve degeneration. ( 22332787 )
2012
23
Lung transplantation for Williams-Campbell syndrome with a probable familial association. ( 22348466 )
2012
24
Williams-Campbell syndrome presenting in an adult. ( 22989422 )
2012
25
Aortopexy as treatment for tracheo-bronchomalacia in children: an 18-year single-center experience. ( 21263370 )
2011
26
Respiratory failure of Williams-Campbell syndrome is effectively treated by noninvasive positive pressure ventilation. ( 21841334 )
2011
27
Resolution of bronchomalacia presenting as severe asthma by endoscopic intervention. ( 21530880 )
2011
28
Clinical management of pediatric tracheo-bronchomalacia. ( 21897163 )
2011
29
Severe bronchomalacia treated by combination of Nuss procedure and aortopexy: an unusual therapy combination. ( 21172474 )
2011
30
Tracheal collapse and bronchomalacia in dogs: 58 cases (7 /2001-1 /2008). ( 20051001 )
2010
31
Handling of extensive aneurysm of the aorta with bronchomalacia in a Marfan patient. ( 20729239 )
2010
32
Bronchomalacia occurring in monozygotic twins--further information about its inheritance. ( 19604169 )
2009
33
Anesthetic management of a pediatric patient with severe Williams-Campbell syndrome undergoing surgery for giant ovarian tumor. ( 18500619 )
2008
34
Noninvasive treatment of bronchomalacia, successful ventilation of a severely ill infant. ( 17429927 )
2007
35
The role of spiral multidetector dynamic CT in the study of Williams-Campbell syndrome. ( 17050358 )
2006
36
CT bronchoscopy in the diagnosis of Williams-Campbell syndrome. ( 16423213 )
2006
37
Relief of bronchial obstruction using a Fogarty catheter in a patient with bronchomalacia. ( 16368809 )
2006
38
Treatment of bronchomalacia in cystic fibrosis by silicone stent. ( 17126148 )
2006
39
Bronchomalacia in sarcoidosis: evaluation on volumetric expiratory high-resolution CT of the lung. ( 15866132 )
2005
40
A decade of using intraluminal tracheal/bronchial stents in the management of tracheomalacia and/or bronchomalacia: is it better than aortopexy? ( 15991168 )
2005
41
Tracheomalacia and bronchomalacia in children: incidence and patient characteristics. ( 16304290 )
2005
42
Tracheomalacia and bronchomalacia in 34 children: clinical and radiologic profiles and associations with other diseases. ( 16327964 )
2005
43
Atypical infantile form of scimitar syndrome with bronchomalacia. ( 17670052 )
2003
44
Tracheomalacia and bronchomalacia in children: pathophysiology, assessment, treatment and anaesthesia management. ( 12535032 )
2003
45
Aortopexy and bronchopexy for the management of severe tracheomalacia and bronchomalacia. ( 12654081 )
2003
46
Series of laryngomalacia, tracheomalacia, and bronchomalacia disorders and their associations with other conditions in children. ( 12203847 )
2002
47
Bronchomalacia associated with pulmonary atresia, ventricular septal defect and major aortopulmonary collateral arteries, and chromosome 22q11.2 deletion. ( 12220436 )
2002
48
[Recurrent pneumonia secondary to idiopathic bronchomalacia]. ( 11412531 )
2001
49
The use of balloon-expandable metallic stents in the treatment of pediatric tracheomalacia and bronchomalacia. ( 10037287 )
1999
50
Bronchopexy for congenital bronchomalacia in the newborn. ( 10466621 )
1999

Variations for Bronchomalacia

Expression for Bronchomalacia

Search GEO for disease gene expression data for Bronchomalacia.

Pathways for Bronchomalacia

GO Terms for Bronchomalacia

Sources for Bronchomalacia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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