MCID: BRN014
MIFTS: 52

Bronchopneumonia

Categories: Respiratory diseases
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Aliases & Classifications for Bronchopneumonia

MalaCards integrated aliases for Bronchopneumonia:

Name: Bronchopneumonia 11 43 14 16 71 75
Lobular Pneumonia 11 71
Chest Infection - Bronchopneumonia 11
Bronchial Pneumonia 11

Classifications:



External Ids:

Disease Ontology 11 DOID:12375
ICD9CM 34 485
MeSH 43 D001996
NCIt 49 C26710
SNOMED-CT 68 155551009
ICD10 31 J18.0
UMLS 71 C0006285 C1275589

Summaries for Bronchopneumonia

Disease Ontology: 11 A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses.

MalaCards based summary: Bronchopneumonia, also known as lobular pneumonia, is related to viral pneumonia and pneumonia, and has symptoms including bronchopneumopathy An important gene associated with Bronchopneumonia is MPO (Myeloperoxidase), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, bone marrow and heart, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia: 75 Bronchopneumonia is a subtype of pneumonia. It is the acute inflammation of the bronchi, accompanied by... more...

Related Diseases for Bronchopneumonia

Diseases related to Bronchopneumonia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1087)
# Related Disease Score Top Affiliating Genes
1 viral pneumonia 30.8 TNF IL6 IL1B IL10 CXCL8 CRP
2 pneumonia 30.8 TNF MPO IL6 IL1B IL10 ELANE
3 haemophilus influenzae 30.4 TNF IL1B CXCL8
4 pleural empyema 30.3 IL6 CRP CD4 ALB
5 cholecystitis 30.2 HP GUSB CRP ALB
6 acute kidney failure 30.1 IL6 HP ALB
7 thrombophlebitis 30.1 SERPINA3 CRP ALB
8 glossitis 30.1 TNF IL6 IL1B
9 pulmonary embolism 30.1 MPO CRP ALB ACE2
10 klebsiella pneumonia 30.0 CRP ALB
11 neutrophilia, hereditary 30.0 MPO IL6 CRP
12 nutritional deficiency disease 30.0 SERPINA3 IL6 CRP ALB
13 arteriosclerosis 30.0 MIR155 IL6 IL10 CRP
14 nocardiosis 30.0 TNF CRP CD4
15 bronchiolitis 30.0 TNF IL6 IL1B IL10 CXCL8 CRP
16 acute cholangitis 30.0 IL6 CRP ALB
17 nephrosclerosis 29.9 TNF MPO ACE2
18 intussusception 29.9 IL6 CRP ALB
19 acute interstitial pneumonia 29.9 IL6 CRP CD8A CD4 ACE2
20 pulmonary fibrosis 29.9 MPO IL1B ELANE CXCL8
21 severe cutaneous adverse reaction 29.9 TNF IL6 CRP CD8A CD4
22 uremia 29.9 TNF IL6 IL1B CRP ALB
23 aspergillosis 29.8 TNF IL6 IL1B IL10 ELANE CXCL8
24 ascaris lumbricoides infection 29.8 IL10 CD4 ALB
25 splenic abscess 29.8 CRP CD8A CD4 ALB
26 megaesophagus 29.8 TNF IL10 CD8A
27 bacterial pneumonia 29.8 TNF SERPINA3 MYD88 MPO IL6 IL1B
28 pasteurellosis 29.8 SERPINA3 MPO HP ELANE CXCL8 ALB
29 bronchiolitis obliterans 29.8 TNF MPO IL6 IL10 CXCL8 CRP
30 lymphatic system disease 29.8 SERPINA3 MIR155 CD8A CD4
31 arthropathy 29.8 TNF IL6 IL1B CRP
32 herpes zoster 29.8 IL10 CD8A CD4
33 chronic pyelonephritis 29.7 SERPINA3 CRP CD68 ALB
34 amyloidosis 29.7 TNF SERPINA3 IL6 IL1B CRP ALB
35 dermatitis herpetiformis 29.7 TNF IL10 CXCL8
36 pulmonary edema 29.7 TNF IL1B IL10 HP CXCL8 CRP
37 bronchitis 29.7 TNF MPO IL6 IL1B IL10 ELANE
38 miliary tuberculosis 29.7 TNF IL10 CRP CD8A CD4 ALB
39 anthracosis 29.7 TNF IL6 IL1B CXCL8
40 liver cirrhosis 29.6 TNF SERPINA3 IL6 HP ALB
41 infective endocarditis 29.6 MPO IL6 CXCL8 CRP ALB
42 aortic dissection 29.6 TNF IL6 ELANE CRP ALB
43 extrinsic allergic alveolitis 29.6 TNF ELANE CXCL8 CD8A CD4
44 encephalitis 29.6 TNF IL6 IL1B IL10 CXCL8
45 interstitial nephritis 29.6 TNF CRP CD8A CD4 ALB
46 dermatitis 29.6 TNF IL6 IL1B IL10 CXCL8
47 autoimmune lymphoproliferative syndrome 29.6 TNF IL10 CD8A CD4
48 chronic granulomatous disease 29.6 TNF MPO IL1B CD8A CD4
49 pleurisy 29.6 TNF MPO IL1B CXCL8 CRP
50 pericarditis 29.6 TNF IL6 IL1B CXCL8 CRP ACE2

Comorbidity relations with Bronchopneumonia via Phenotypic Disease Network (PDN): (show all 31)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alzheimer Disease, Familial, 1
Anxiety Bronchiectasis
Bronchitis Cerebral Atherosclerosis
Chronic Kidney Disease Chronic Pulmonary Heart Disease
Decubitus Ulcer Deficiency Anemia
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Heart Disease
Hypothyroidism Idiopathic Interstitial Pneumonia
Iron Deficiency Anemia Kidney Disease
Oral Candidiasis Osteoporosis
Paralytic Ileus Parkinson Disease, Late-Onset
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Protein-Energy Malnutrition Respiratory Failure
Schizophreniform Disorder Swallowing Disorders
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Bronchopneumonia:



Diseases related to Bronchopneumonia

Symptoms & Phenotypes for Bronchopneumonia

UMLS symptoms related to Bronchopneumonia:


bronchopneumopathy

MGI Mouse Phenotypes related to Bronchopneumonia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACE2 ALB CD4 CRP ELANE GUSB
2 immune system MP:0005387 10.16 ACE2 ALB CD4 CD68 CD8A CRP
3 cellular MP:0005384 10.1 ACE2 ALB CD4 CD8A GUSB HP
4 neoplasm MP:0002006 10.03 ALB ELANE HP IL10 IL1B IL6
5 hematopoietic system MP:0005397 10.03 ACE2 CD4 CD68 CD8A ELANE GUSB
6 digestive/alimentary MP:0005381 10.02 ACE2 ALB CD4 IL10 IL6 MIR155
7 mortality/aging MP:0010768 9.8 ACE2 ALB CD4 CD8A ELANE GUSB
8 integument MP:0010771 9.4 ACE2 CD4 CD8A ELANE GUSB IL10

Drugs & Therapeutics for Bronchopneumonia

Drugs for Bronchopneumonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Individualizing Duration of Antibiotic Therapy in Hospitalized Patients With Community - Acquired Pneumonia: a Non-inferiority, Randomized, Controlled Trial. Unknown status NCT01492387 Phase 4
2 Evaluation of the Treatment With Klacid SR in Patients With Acute Tracheitis, Tracheobronchitis and Bronchitis, Acute Exacerbation of Chronic Bronchitis or Mild Community-acquired Bronchopneumonia in Common Clinical Practice in the Slovak Republic Completed NCT01108185

Search NIH Clinical Center for Bronchopneumonia

Cochrane evidence based reviews: bronchopneumonia

Genetic Tests for Bronchopneumonia

Anatomical Context for Bronchopneumonia

Organs/tissues related to Bronchopneumonia:

MalaCards : Lung, Bone Marrow, Heart, Myeloid, Liver, Spleen, Kidney

Publications for Bronchopneumonia

Articles related to Bronchopneumonia:

(show top 50) (show all 3648)
# Title Authors PMID Year
1
Tuberculous and non-tuberculous cervical lymphadenopathy incidence and distribution in Somalia from 2016 to 2020: A review of 241 cases. 62
36474662 2022
2
Pathological and etiological characterization of cases of bovine abortion due to sporadic bacterial and mycotic infections. 62
36303022 2022
3
Temporal Transcriptome Analysis of SARS-CoV-2-Infected Lung and Spleen in Human ACE2-Transgenic Mice. 62
36324270 2022
4
Three Zone Scanning Protocol For Lung Ultrasound: An Anatomical Basis. 62
36400698 2022
5
First detection of Psittacid alphaherpesvirus 5 and coinfection with beak and feather disease virus in naturally infected captive ringneck parakeets (Psittacula krameri) in Brazil. 62
35962822 2022
6
Anatabine attenuates ovalbumin-induced asthma via oxidative stress and inflammation mitigation and Nrf2/HO-1 signaling upregulation in rats. 62
36103960 2022
7
Comprehensive Molecular Characterization of the Mitochondrial Genome of the Takin Lungworm Varestrongylus eleguneniensis (Strongylida: Protostrongylidae). 62
36362384 2022
8
Hospitalization costs for children with pneumonia in Shanghai, China from 2019 to 2020. 62
35653718 2022
9
Histopathological pulmonary findings of survivors and autopsy COVID-19 cases: A bi-center study. 62
36451501 2022
10
An uncommon cause of spontaneous pneumothorax in a febrile infant: Atypical Kawasaki disease. 62
35791042 2022
11
Role of chest radiography in the diagnosis of pulmonary tuberculosis during nCovid19 pandemic. 62
36460367 2022
12
Biruni Index as a Novel Diagnostic Tool for the Early Prediction of Mortality in Critical Patients With COVID-19: A Cohort Study. 62
36439611 2022
13
Sleep cycle in children with severe acute bronchopneumonia during mechanical ventilation at different depths of sedation. 62
36224544 2022
14
A Medication Hiccup: Chlorpromazine-Induced Agranulocytosis in a 72-Year-Old Male. 62
36301662 2022
15
Assessing the Impact of Meteorological Conditions on Outpatient Visits for Childhood Respiratory Diseases in Urumqi, China. 62
35959921 2022
16
Feline non-erosive immune-mediated polyarthritis: a multicentre, retrospective study of 20 cases (2009-2020). 62
35762267 2022
17
Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis. 62
35636669 2022
18
Validating a bovine model for lung ultrasound of bronchiolitis. 62
35067896 2022
19
Remarks on the management of proximal femoral fractures in times of COVID-19 pandemic. 62
36155723 2022
20
[Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2]. 62
36165016 2022
21
Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan. 62
36137926 2022
22
Delayed Surgical Management of Acute Type A Aortic Dissection in a Patient with Recent COVID-19 Infection and Post-COVID-19 Bronchopneumonia-Case Report and Review of Literature. 62
36295518 2022
23
Cardiac macrophage density in Covid-19 infection: relationship to myocyte necrosis and acute lung injury. 62
35718082 2022
24
Understanding the mechanisms of viral and bacterial coinfections in bovine respiratory disease: a comprehensive literature review of experimental evidence. 62
36068558 2022
25
Emphasizing Pulmonary Function With Respiratory Therapy in an Infant With Congenital Adrenal Hyperplasia, Bronchopneumonia and Leptomeningitis. 62
36199651 2022
26
Pulmonary Histopathology in Cats and Dogs with Fatal Tick Paralysis. 62
36089296 2022
27
Re-administration of SmallPox vaccine against MonkeyPox among general population; after more 30 Years of vaccine cessation by WHO. 62
36147105 2022
28
Ultrasonographic diagnosis of clinical and subclinical bovine respiratory disease in Holstein calves. 62
36313833 2022
29
Long-Term Infection and Pathogenesis in a Novel Mouse Model of Human Respiratory Syncytial Virus. 62
36016362 2022
30
Clinical implications of Golgi protein 73 and granulocyte colony-stimulating factor and their related factors in children with bronchopneumonia. 62
35988659 2022
31
Expression of Concern: "Luteolin alleviates LPS-induced bronchopneumonia injury in vitro and in vivo by down-regulating microRNA-132 expression" [Biomedicine & Pharmacotherapy 106 (2018) 1641-1649]. 62
35725097 2022
32
Laboratory investigation of cases of fatal bacterial pneumonia in dairy cows. 62
35919462 2022
33
Radiological patterns and prognosis in elderly patients with acute Klebsiella pneumoniae pneumonia: A retrospective study. 62
35960104 2022
34
Retrospective study of pneumonia in non-racing horses in California. 62
35535386 2022
35
Surfactant proteins analysis in perinatal deceased preterm twins among the Romanian population. 62
35905206 2022
36
Rhabdomyolysis, myoglobinuric nephrosis, and crystalline nephropathy in a captive bottlenose dolphin. 62
35477373 2022
37
Outbreak of Yersinia pseudotuberculosis in capybaras (Hydrochoerus hydrochaeris) kept in captivity. 62
35468346 2022
38
Fatal Bronchopneumonia and Tracheitis in a Green Turtle (Chelonia mydas) Caused by Serratia proteamaculans. 62
35892541 2022
39
A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005-2020). 62
35395230 2022
40
HoBi-like pestivirus in 2 cases of fatal respiratory disease of feedlot cattle in Argentina. 62
35593639 2022
41
A hybrid lesion of intralobar sequestration with mixed features of CPAM type I and type II unmasked following SARS-CoV-2 infection: Case report and literature review. 62
35753231 2022
42
Investigation of SARS-CoV-2 infection and associated lesions in exotic and companion animals. 62
35038930 2022
43
Monkeypox has devastated the world; should we prepare for the outbreak of a new pandemic? 62
35860122 2022
44
Clinical characteristics of recurrent pneumonia in children with or without underlying diseases. 62
34454794 2022
45
Causes of death among 93.637 hip fracture patients- data based on the Danish National Registry of causes of death. 62
34590173 2022
46
Infectious Disease Agents Associated with Pulmonary Alterations in Aborted Bovine Fetuses. 62
35804494 2022
47
Mechanical Ventilation Associated Pneumomediastinum - A Rising Incidence of Cases in an Emergency Hospital During the COVID-19 Pandemics. 62
35792542 2022
48
Severe Retroperitoneal Hemorrhage in a COVID-19 Patient on a Therapeutic Dose of Low Molecular Weight Heparin: A Case Report. 62
35898364 2022
49
VATS surgical anatomical resection of bronchopulmonary sequestration presenting as chest sepsis. 62
35619115 2022
50
CT features of community-acquired pneumonia at the emergency department. 62
35489109 2022

Variations for Bronchopneumonia

Expression for Bronchopneumonia

Search GEO for disease gene expression data for Bronchopneumonia.

Pathways for Bronchopneumonia

Pathways related to Bronchopneumonia according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.61 CD4 CD68 CD8A CRP CXCL8 ELANE
2
Show member pathways
13.4 TNF MYD88 IL6 IL1B IL10 CXCL8
3
Show member pathways
13.32 TNF MYD88 IL6 IL1B IL10 CXCL8
4
Show member pathways
12.87 CXCL8 IL1B IL6 MIR155 MYD88 TNF
5
Show member pathways
12.64 TNF MPO IL6 IL1B IL10 CD4
6
Show member pathways
12.63 TNF MYD88 IL6 IL1B CXCL8
7 12.61 TNF MYD88 MPO IL1B IL10 CD8A
8
Show member pathways
12.55 TNF MYD88 IL6 IL1B CXCL8
9
Show member pathways
12.45 TNF MYD88 IL6 IL1B CXCL8
10
Show member pathways
12.35 TNF MYD88 IL6 IL1B CXCL8
11 12.22 TNF IL6 IL1B IL10 CXCL8
12
Show member pathways
12.19 CD4 CD8A IL10 MYD88 TNF
13 12.12 TNF IL6 IL1B IL10
14 12.02 TNF IL6 IL1B CXCL8
15 12.02 TNF IL6 IL1B IL10 CXCL8
16
Show member pathways
11.97 TNF IL6 IL1B IL10 CD4
17 11.92 TNF IL1B IL10 CXCL8
18 11.84 TNF IL1B IL10 CD8A CD4
19 11.8 TNF MYD88 IL6 IL1B CXCL8
20 11.78 MPO ELANE CD4
21 11.76 TNF NEAT1 IL6 IL10 CRP
22 11.75 IL6 IL10 CD4
23
Show member pathways
11.74 TNF IL6 IL1B CXCL8
24 11.73 TNF IL6 IL1B CXCL8
25 11.72 IL6 IL1B CD4
26 11.71 IL6 IL10 CXCL8
27
Show member pathways
11.69 IL6 CXCL8 CRP CD8A CD4 ACE2
28 11.67 TNF MYD88 IL6 IL1B IL10
29
Show member pathways
11.64 TNF IL6 IL10
30 11.61 CXCL8 IL6 MIR155
31 11.61 TNF IL10 CXCL8 ACE2
32 11.6 CD4 MYD88 TNF
33 11.6 TNF IL6 IL1B IL10 CD8A CD4
34 11.57 TNF IL6 CXCL8
35 11.56 TNF MPO IL6 IL10 CD8A CD68
36 11.51 TNF IL6 IL1B
37 11.5 TNF IL6 IL1B IL10 CXCL8
38 11.49 TNF MYD88 IL6
39 11.43 TNF IL6 IL1B IL10
40 11.35 TNF IL6 IL1B
41 11.31 CXCL8 IL1B IL6 TNF
42 11.28 TNF IL6 IL10 CXCL8
43 11.28 TNF IL6 IL1B CXCL8 ACE2
44 11.23 TNF IL6 IL1B IL10 CD4
45 11.14 IL10 IL1B IL6
46 11.07 TNF IL6 CXCL8 CRP
47 10.96 CD68 IL1B MPO TNF
48 10.96 TNF MYD88 MIR155 IL6 IL10 ELANE
49 10.78 IL6 CXCL8 ACE2
50
Show member pathways
10.44 TNF IL6 CXCL8

GO Terms for Bronchopneumonia

Cellular components related to Bronchopneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.1 ACE2 ALB CD8A CRP CXCL8 ELANE
2 azurophil granule lumen GO:0035578 9.76 SERPINA3 MPO GUSB ELANE
3 extracellular space GO:0005615 9.74 TNF SERPINA3 MPO IL6 IL1B IL10

Biological processes related to Bronchopneumonia according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.31 TNF SERPINA3 MYD88 IL6 IL1B CXCL8
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.27 CD4 IL1B MYD88 TNF VAPA
3 positive regulation of DNA-binding transcription factor activity GO:0051091 10.24 TNF IL6 IL1B IL10
4 immune response GO:0006955 10.24 TNF IL6 IL1B IL10 CXCL8 CD8A
5 defense response to bacterium GO:0042742 10.22 ELANE HP IL10 MPO MYD88 TNF
6 positive regulation of interleukin-6 production GO:0032755 10.21 TNF MYD88 IL6 IL1B
7 defense response to Gram-positive bacterium GO:0050830 10.16 TNF MYD88 IL6 IL1B CRP
8 lipopolysaccharide-mediated signaling pathway GO:0031663 10.12 TNF MYD88 IL1B
9 defense response GO:0006952 10.11 TNF MPO HP CXCL8
10 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.11 IL10 IL6 TNF
11 positive regulation of smooth muscle cell proliferation GO:0048661 10.11 TNF MYD88 IL6 ELANE
12 liver regeneration GO:0097421 10.08 IL10 IL6 TNF
13 positive regulation of cytokine production involved in inflammatory response GO:1900017 10.07 TNF MYD88 IL6
14 negative regulation of neurogenesis GO:0050768 10.06 TNF IL6 IL1B
15 positive regulation of glial cell proliferation GO:0060252 10.02 TNF IL6 IL1B
16 positive regulation of heterotypic cell-cell adhesion GO:0034116 10 IL10 IL1B TNF
17 positive regulation of chemokine production GO:0032722 9.98 TNF MYD88 IL6 IL1B
18 negative regulation of cytokine production involved in immune response GO:0002719 9.96 TNF IL10
19 positive regulation of fever generation GO:0031622 9.95 TNF IL1B
20 positive regulation of synoviocyte proliferation GO:1901647 9.93 TNF NEAT1
21 sequestering of triglyceride GO:0030730 9.92 TNF IL1B
22 acute-phase response GO:0006953 9.92 SERPINA3 IL6 HP CRP
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.9 TNF IL1B
24 positive regulation of neuroinflammatory response GO:0150078 9.88 IL1B IL6 TNF
25 response to gold nanoparticle GO:1990268 9.87 TNF MPO
26 chronic inflammatory response to antigenic stimulus GO:0002439 9.86 TNF IL10
27 negative regulation of lipid storage GO:0010888 9.85 TNF IL6 CRP
28 response to lipopolysaccharide GO:0032496 9.81 ELANE IL10 IL1B MPO MYD88 TNF
29 leukocyte migration GO:0050900 9.79 TNF IL1B ELANE
30 vascular endothelial growth factor production GO:0010573 9.73 TNF IL6 IL1B
31 positive regulation of interleukin-8 production GO:0032757 9.65 TNF MYD88 IL6 IL1B ELANE
32 cellular response to lipopolysaccharide GO:0071222 9.44 TNF MYD88 IL6 IL1B IL10 CXCL8

Molecular functions related to Bronchopneumonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.28 TNF IL6 IL1B IL10 CXCL8

Sources for Bronchopneumonia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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