BPD
MCID: BRN056
MIFTS: 57

Bronchopulmonary Dysplasia (BPD)

Categories: Fetal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchopulmonary Dysplasia

MalaCards integrated aliases for Bronchopulmonary Dysplasia:

Name: Bronchopulmonary Dysplasia 53 59 55 38 63 72
Bpd 53 59

Characteristics:

Orphanet epidemiological data:

59
bronchopulmonary dysplasia
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:



External Ids:

MESH via Orphanet 45 D001997
ICD10 via Orphanet 34 P27.1
UMLS via Orphanet 73 C0006287
Orphanet 59 ORPHA70589
UMLS 72 C0006287

Summaries for Bronchopulmonary Dysplasia

PubMed Health : 63 About bronchopulmonary dysplasia: Bronchopulmonary (BRONG-ko-PUL-mo-NAR-e) dysplasia (dis-PLA-ze-ah), or BPD, is a serious lung condition that affects infants. BPD mostly affects premature infants who need oxygen therapy (oxygen given through nasal prongs, a mask, or a breathing tube). Most infants who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds (about 1,000 grams) at birth, and have breathing problems. Infections that occur before or shortly after birth also can contribute to BPD. Some infants who have BPD may need long-term breathing support from nasal continuous positive airway pressure (NCPAP) machines or ventilators.

MalaCards based summary : Bronchopulmonary Dysplasia, also known as bpd, is related to bronchial disease and acute respiratory distress syndrome. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are G-protein signaling RAC1 in cellular process and Immune response IFN alpha/beta signaling pathway. The drugs Procaterol and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include Lung and Lung, and related phenotypes are emphysema and respiratory distress

NIH Rare Diseases : 53 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 70589DefinitionBronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome (see these terms) in low-birth-weight premature infants or from abnormal lung development in older infants. Clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring.Visit the Orphanet disease page for more resources.

Wikipedia : 75 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disease in... more...

Related Diseases for Bronchopulmonary Dysplasia

Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 267)
# Related Disease Score Top Affiliating Genes
1 bronchial disease 31.7 RNASE3 ELANE CXCL8
2 acute respiratory distress syndrome 31.2 SFTPB ELANE CXCL8
3 pneumonia 31.1 SFTPB ELANE CXCL8
4 newborn respiratory distress syndrome 31.0 SFTPB SCGB1A1 ELANE CXCL8
5 respiratory failure 31.0 SFTPB SCGB1A1 ELANE CXCL8
6 lung disease 30.9 SFTPB RNASE3 ELANE CXCL8
7 interstitial emphysema 30.8 FLT1 ELANE
8 chorioamnionitis 30.6 IL1RN FLT1 ELANE CXCL8
9 adult respiratory distress syndrome 30.6 SFTPB ELANE CXCL8
10 interstitial lung disease 30.5 TIMP1 SFTPB CXCL8
11 bronchiolitis obliterans 30.2 TIMP1 SCGB1A1 CXCL8
12 bronchitis 29.9 RNASE3 ELANE CXCL8
13 bacterial infectious disease 29.7 SELL ITGAM ELANE CXCL8
14 bacterial sepsis 29.6 ELANE CXCL8
15 rhinitis 29.5 SCGB1A1 RNASE3 CXCL8
16 proteasome-associated autoinflammatory syndrome 1 28.9 SELL RNASE3 IL1RN ELANE CXCL8
17 pulmonary fibrosis, idiopathic 28.8 TIMP1 SFTPB SCGB1A1 IL1RN ELANE CXCL8
18 pulmonary disease, chronic obstructive 28.6 TIMP1 SFTPB SCGB1A1 RNASE3 ELANE CXCL8
19 asthma 27.6 SELL SCGB1A1 RNASE3 ITGAM IL1RN ELANE
20 borderline personality disorder 11.8
21 pulmonary hypertension, neonatal 11.3
22 multiple personality disorder 11.2
23 pulmonary hypertension 10.9
24 personality disorder 10.9
25 patent ductus arteriosus 1 10.9
26 respiratory distress syndrome in premature infants 10.7
27 exudative vitreoretinopathy 1 10.7
28 cerebral palsy 10.6
29 enterocolitis 10.6
30 toxicodendron dermatitis 10.6 SELL CXCL8
31 perinatal necrotizing enterocolitis 10.6
32 toxic myocarditis 10.5 SOD1 CXCL8
33 periventricular leukomalacia 10.5
34 pre-eclampsia 10.5
35 cardiac rupture 10.5 ELANE CXCL8
36 paraquat lung 10.5 SFTPB SCGB1A1
37 pouchitis 10.5 IL1RN CXCL8
38 pneumothorax 10.5
39 toxic pneumonitis 10.5 SFTPB SCGB1A1
40 capillary leak syndrome 10.5 ELANE CXCL8
41 vascular disease 10.5
42 bronchiolitis 10.5
43 avoidant personality disorder 10.5
44 pulmonary fibrosis 10.4
45 idiopathic interstitial pneumonia 10.4
46 cryptogenic organizing pneumonia 10.4 TIMP1 CXCL8
47 necrotizing fasciitis 10.4 IL1RN CXCL8
48 arthus reaction 10.4 SELL ELANE
49 cyclic neutropenia 10.4 ELANE CXCL8
50 pulmonary edema 10.4

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to Bronchopulmonary Dysplasia

Symptoms & Phenotypes for Bronchopulmonary Dysplasia

Human phenotypes related to Bronchopulmonary Dysplasia:

59 32 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 emphysema 59 32 hallmark (90%) Very frequent (99-80%) HP:0002097
2 respiratory distress 59 32 hallmark (90%) Very frequent (99-80%) HP:0002098
3 cough 59 32 hallmark (90%) Very frequent (99-80%) HP:0012735
4 premature birth 59 32 hallmark (90%) Very frequent (99-80%) HP:0001622
5 respiratory failure requiring assisted ventilation 59 32 hallmark (90%) Very frequent (99-80%) HP:0004887
6 small for gestational age 59 32 hallmark (90%) Very frequent (99-80%) HP:0001518
7 chronic lung disease 59 32 hallmark (90%) Very frequent (99-80%) HP:0006528
8 hyperoxemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0012419
9 sleep disturbance 59 32 frequent (33%) Frequent (79-30%) HP:0002360
10 exercise intolerance 59 32 frequent (33%) Frequent (79-30%) HP:0003546
11 diaphragmatic paralysis 59 32 frequent (33%) Frequent (79-30%) HP:0006597
12 central apnea 59 32 frequent (33%) Frequent (79-30%) HP:0002871
13 wheezing 59 32 frequent (33%) Frequent (79-30%) HP:0030828
14 right ventricular hypertrophy 59 32 frequent (33%) Frequent (79-30%) HP:0001667
15 right ventricular failure 59 32 frequent (33%) Frequent (79-30%) HP:0001708
16 atelectasis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100750
17 tracheobronchomalacia 59 32 occasional (7.5%) Occasional (29-5%) HP:0002786
18 pulmonary sequestration 59 32 occasional (7.5%) Occasional (29-5%) HP:0100632
19 dyspnea 59 Very frequent (99-80%)
20 functional respiratory abnormality 59 Frequent (79-30%)
21 abnormal lung morphology 59 Very frequent (99-80%)
22 abnormal respiratory system morphology 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 ELANE FGF10 FLT1 IL1RN ITGAM RBP4
2 cardiovascular system MP:0005385 9.87 FGF10 FLT1 IL1RN RBP4 SELL SOD1
3 hematopoietic system MP:0005397 9.86 ELANE FGF10 FLT1 IL1RN ITGAM SELL
4 immune system MP:0005387 9.61 ELANE FGF10 FLT1 IL1RN ITGAM SCGB1A1
5 neoplasm MP:0002006 9.02 ELANE SCGB1A1 SELL SOD1 TIMP1

Drugs & Therapeutics for Bronchopulmonary Dysplasia

PubMed Health treatment related to Bronchopulmonary Dysplasia: 63

If your doctor thinks you're going to give birth too early, he or she may give you injections of a corticosteroid medicine. The medicine can speed up surfactant production in your baby. Surfactant is a liquid that coats the inside of the lungs. It helps keep the lungs open so your infant can breathe in air once he or she is born. Corticosteroids also can help your baby's lungs, brain, and kidneys develop more quickly while he or she is in the womb. Premature babies who have very low birth weights also might be given corticosteroids within the first few days of birth. Doctors sometimes prescribe inhaled nitric oxide shortly after birth for babies who have very low birth weights. This treatment can help improve the babies' lung function. These preventive measures may help reduce infants' risk of respiratory distress syndrome (RDS), which can lead to BPD.

Drugs for Bronchopulmonary Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 199)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3
Zinc Approved, Investigational Phase 4 7440-66-6 32051
4
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6 Vitamins Phase 4
7 Calciferol Phase 4
8 Bone Density Conservation Agents Phase 4
9 Antibodies Phase 4
10 Immunoglobulins Phase 4
11 Lactoferrin Phase 4
12 Immunologic Factors Phase 4
13 Vaccines Phase 4
14 Hormones Phase 4
15 Hormone Antagonists Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Anti-Inflammatory Agents Phase 4
18 glucocorticoids Phase 4
19 Micronutrients Phase 4
20 Trace Elements Phase 4
21 Nutrients Phase 4
22 Dermatologic Agents Phase 4
23 Astringents Phase 4
24
Clarithromycin Approved Phase 3 81103-11-9 84029
25
Furosemide Approved, Vet_approved Phase 2, Phase 3 54-31-9 3440
26
Chlorothiazide Approved, Vet_approved Phase 2, Phase 3 58-94-6 2720
27
Spironolactone Approved Phase 2, Phase 3 1952-01-7, 52-01-7 5833
28
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
29
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
30
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
31
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
32
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
33
Nitric Oxide Approved Phase 3 10102-43-9 145068
34
Calfactant Approved Phase 3 183325-78-2
35
Palivizumab Approved, Investigational Phase 2, Phase 3 188039-54-5
36
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
37
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
38
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
39
Ethanol Approved Phase 3 64-17-5 702
40
Benzyl alcohol Approved Phase 3 100-51-6 244
41
Ampicillin Approved, Vet_approved Phase 3 69-53-4 6249
42
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
43
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
44
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 5280795
45
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
46
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
47
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
48
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
49 Tocotrienol Investigational Phase 3 6829-55-6
50 Cytochrome P-450 CYP3A Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 335)
# Name Status NCT ID Phase Drugs
1 Early Administration of Surfactant in Spontaneous Breathing (TAKE CARE) Versus InSurE (Intubation, Surfactant, Extubation) : A Pilot Study Unknown status NCT01329432 Phase 4
2 Early Bubble CPAP (EBCPAP) in Very Low Birth Weight Infants (VLBWI) Unknown status NCT00368680 Phase 4
3 THE EFFECT OF SUSTAINED LUNG INFLATION MANEUVER APPLIED THROUGH NASAL PRONG ON EARLY AND LATE RESPIRATORY MORBIDITIES IN PRETERM INFANTS Unknown status NCT02887924 Phase 4
4 Prevention of Chronic Lung Disease (CLD) in Preterm Infants -A New Therapeutic Regimen Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
5 The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia (BPD). Completed NCT00926276 Phase 4
6 Albuterol Dose-Response on Pulmonary Function Testing in Preterm Infants at Risk of Bronchopulmonary Dysplasia Completed NCT02447250 Phase 4 Varied albuterol dose response
7 Randomized Clinical Trial: Use of Azithromycin to Prevent Lung Damage in Preterm Newborns Under Mechanical Ventilation Completed NCT03485703 Phase 4 Azithromycin;Placebo
8 Systematic Randomized , Single Blinded, Placebo-Controlled Trial of Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis Completed NCT02959229 Phase 4 Lactoferrin;Placebo (for Lactoferrin)
9 Multi-dose Vitamin D Supplementation in Preterm Infants Completed NCT02941185 Phase 4 Devit-3 Oral Drop
10 Prevention of RSV Infections in Bone Marrow Transplant Recipients Completed NCT00001903 Phase 4 RSV Polyclonal Immunoglobulin
11 A Randomized Trial to Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates in Developing Countries Completed NCT01403623 Phase 4
12 Randomized Evaluation of the Use of Plastic Bags to Prevent Neonatal Hypothermia in Developing Countries-Part IV Completed NCT01604447 Phase 4
13 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
14 Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome. Recruiting NCT03521063 Phase 4 Budesonide;Poractant Alfa;Saline
15 Multicentre Randomised Controlled Trial of Minimally-invasive Surfactant Therapy in Preterm Infants 25-28 Weeks Gestation on Continuous Positive Airways Pressure Recruiting NCT02140580 Phase 4
16 A Randomized, Placebo-controlled Trial of Early Caffeine in Preterm Neonates Recruiting NCT03086473 Phase 4 Caffeine Citrate;Placebo (Normal Saline)
17 Exogenous Surfactant in Very Preterm Neonates Presenting With Severe Respiratory Distress in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4 Curosurf
18 Oral Zinc Supplementation Improving Growth and Reducing Morbidity on Very Low Birth Weight Infant Not yet recruiting NCT04050488 Phase 4 Zinc Sulfate;Placebos
19 Routine Administration of Surfactant/Budesonide to Prevent BPD in VLBW With RDS-A Double Blind Study Not yet recruiting NCT03275415 Phase 4 budesonide;Saline
20 Impact of Early Postnatal Sodium Supplementation on Weight Gain in Very Low Birth Weight Infants Terminated NCT01795638 Phase 4 Sodium chloride;Placebo
21 Rate of Bronchopulmonary Dysplasia in Preterms Neonates Less Than 29 Weeks' Gestational Age and / or With Birth Weight Less Than 1000 g: a Double Blind Randomized Controlled Multicenter Trial Comparing SMOFlipid and Medialipide Withdrawn NCT02853253 Phase 4
22 Prophylaxis of Bronchopulmonary Dysplasia With Clarithromycin Unknown status NCT01652118 Phase 3 clarithromycin treatment for prophylaxis of bronchopulmonary dysplasia;Saline
23 Trial of Late Surfactant for Prevention of Bronchopulmonary Dysplasia: A Study in Ventilated Preterm Infants Receiving Inhaled Nitric Oxide Unknown status NCT01022580 Phase 3 Infasurf surfactant (ONY, Inc.)
24 Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease Unknown status NCT01721655 Phase 2, Phase 3 Spironolactone;Placebo
25 Use of Orotracheal CPAP ( Gregory System) for Treatment of Respiratory Failure in Newborns Unknown status NCT01379820 Phase 2, Phase 3
26 Evaluating the Efficacy and Safety of an Innovative and Affordable Goat Lung Surfactant for the Treatment of Respiratory Distress Syndrome in Preterm Neonates: a Multi-site Randomized Clinical Trial Unknown status NCT02774044 Phase 2, Phase 3 Cadisurf;Survanta
27 Effect of Cysteine Supplementation on Glutathione Production in Critically Ill Neonates Unknown status NCT00254176 Phase 2, Phase 3
28 Phase III Randomized, Double-Blind Study of Dexamethasone Vs Dexamethasone/Methylprednisolone Vs Placebo for Bronchopulmonary Dysplasia Completed NCT00004785 Phase 3 dexamethasone;methylprednisolone
29 Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia in Preterm Infants Completed NCT01503801 Phase 2, Phase 3 Nitric Oxide
30 Inhaled Nitric Oxide (INO) for the Prevention of Bronchopulmonary Dysplasia (BPD) in Preterm Infants Requiring Mechanical Ventilation or Positive Pressure Support on Days 5-14 After Birth Completed NCT00931632 Phase 3 Inhaled Nitric Oxide;Placebo
31 Inhaled Beclomethasone to Prevent Chronic Lung Disease Completed NCT00000576 Phase 3 beclomethasone
32 A Randomized Controlled Trial of Two Hemoglobin Thresholds for Transfusion in Newborns <1000g Birth Weight Completed NCT00182390 Phase 3
33 A Prospective, Multicenter, Open-label, Non-comparative Study of Safety and Efficacy of Synagis in Children at High Risk of Severe Respiratory Syncytial Virus Infection in the Russian Federation Completed NCT01006629 Phase 2, Phase 3
34 Trial of Late Surfactant to Prevent BPD: A Pilot Study in Ventilated Preterm Neonates Receiving Inhaled Nitric Oxide Completed NCT00569530 Phase 3 Infasurf (ONY Inc.);Sham
35 Efficacy and Safety of Inhaled Budesonide in Very Preterm Infants at Risk for Bronchopulmonary Dysplasia Completed NCT01035190 Phase 3 Budesonide
36 Efficacy and Safety of NIPPV to Increase Survival Without Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants Completed NCT00433212 Phase 3
37 Early Prevention of Broncho-pulmonary Dysplasia and Neonatal Mortality in Very Preterm Infants Using Low Dose of Hydrocortisone: a Randomized Controlled Trial Completed NCT00623740 Phase 3 hydrocortisone;placebo
38 High Frequency Ventilation in Premature Infants (HIFI) Completed NCT00000567 Phase 3
39 Inhaled NO in Prevention of Chronic Lung Disease Completed NCT00000548 Phase 3
40 Efficacy and Safety of Exosurf Neonatal and Survanta for the Treatment of Respiratory Distress Syndrome Completed NCT01203358 Phase 2, Phase 3 Exosurf;Survanta
41 Effect of Early Use of Caffeine Citrate in Preterm Neonates Needing Respiratory Support. Completed NCT04001712 Phase 3 Caffeine Citrate
42 A Prospective, International, Multicenter, Open-Label, Non-Controlled Study of Safety and Effectiveness of Palivizumab, in Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus Completed NCT02968173 Phase 3 Palivizumab
43 Human Surfactant Treatment of Respiratory Distress Syndrome Bicenter Trial Completed NCT00000570 Phase 3 pulmonary surfactant
44 Phase 3 Multicenter, Randomized, Open Label Trial of a New Low Cost Animal Extracted Surfactant to Treat Respiratory Distress Syndrome in Preterm Infants Completed NCT02305160 Phase 2, Phase 3 Butantan;Control
45 A Randomized, Controlled Trial of Synchronized Nasal Intermittent Positive Pressure Ventilation Versus Nasal Continuous Positive Airway Pressure Using the Infant Flow Advance to Facilitate Successful Extubation in Premature Infants. Completed NCT00188968 Phase 3
46 Inhaled NO for the Prevention of Chronic Lung Disease Completed NCT00006401 Phase 3 iNO
47 L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Transient Hypothyroxinemia of Prematurity: a Prospective Randomized Double-blind Trial Completed NCT01306227 Phase 3 L-Thyroxine;water
48 Early Vitamin D Supplementation for Prevention of Respiratory Morbidity in Extremely Preterm Infants: A Randomized Clinical Trial Completed NCT01600430 Phase 2, Phase 3
49 Randomized Comparison of Two Models of Post-NICU Care for Preterm Infants With Neonatal Chronic Lung Disease Completed NCT00314431 Phase 3
50 Long-Term Effects On Sleep Of Methylxanthine Therapy For Apnea Of Prematurity Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo

Search NIH Clinical Center for Bronchopulmonary Dysplasia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bronchopulmonary Dysplasia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bronchopulmonary Dysplasia:
PNEUMOSTEM, cord blood-derived mesenchymal stem cells for bronchopulmonary dysplasia

Genetic Tests for Bronchopulmonary Dysplasia

Anatomical Context for Bronchopulmonary Dysplasia

MalaCards organs/tissues related to Bronchopulmonary Dysplasia:

41
Lung, Endothelial, Brain, Bone, Testes, Fetal Lung, Colon
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bronchopulmonary Dysplasia:
# Tissue Anatomical CompartmentCell Relevance
1 Lung Pulmonary Capillary Plexus Affected by disease
2 Lung Alveoli Alveolar Epithelial Type 1 Cells Affected by disease, potential therapeutic candidate
3 Lung Alveoli Alveolar Epithelial Type 2 Cells Affected by disease, potential therapeutic candidate

Publications for Bronchopulmonary Dysplasia

Articles related to Bronchopulmonary Dysplasia:

(show top 50) (show all 6365)
# Title Authors PMID Year
1
Clara cell secretory protein (CC16) as a peripheral blood biomarker of lung injury in ventilated preterm neonates. 9 38
18521628 2008
2
Gastrin-releasing peptide, immune responses, and lung disease. 9 38
19076373 2008
3
Cord blood Clara cell protein CC16 predicts the development of bronchopulmonary dysplasia. 9 38
18521627 2008
4
FGF-10 is decreased in bronchopulmonary dysplasia and suppressed by Toll-like receptor activation. 9 38
17071719 2007
5
Selectin polymorphisms and perinatal morbidity in low-birthweight infants. 9 38
16982492 2006
6
Lower parathyroid hormone-related protein content of tracheal aspirates in very low birth weight infants who develop bronchopulmonary dysplasia. 9 38
16864707 2006
7
Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. 9 38
16856062 2006
8
The safety, pharmacokinetics, and anti-inflammatory effects of intratracheal recombinant human Clara cell protein in premature infants with respiratory distress syndrome. 9 38
15774846 2005
9
Erythrocyte Cu/Zn superoxide dismutase activity in preterm infants with and without bronchopulmonary dysplasia. 9 38
15767740 2005
10
Distribution of antioxidant enzymes in developing human lung, respiratory distress syndrome, and bronchopulmonary dysplasia. 9 38
15314090 2004
11
Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. 9 38
14711863 2004
12
Interleukin-10 inhibits proinflammatory chemokine release by neutrophils of the newborn without suppression of nuclear factor-kappa B. 9 38
12788980 2003
13
Soluble E-selectin, soluble L-selectin and soluble ICAM-1 in bronchopulmonary dysplasia, and changes with dexamethasone. 9 38
12612222 2003
14
Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in mouse and human airways. 9 38
12406855 2002
15
Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease. 9 38
12475802 2002
16
High concentrations of keratinocyte growth factor in airways of premature infants predicted absence of bronchopulmonary dysplasia. 9 38
12016100 2002
17
Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. 9 38
11734454 2001
18
Monocyte chemoattractant protein-1 and interleukin-8 are increased in bronchopulmonary dysplasia: relation to isolation of Ureaplasma urealyticum. 9 38
11478413 2001
19
Superoxide dismutase for preventing chronic lung disease in mechanically ventilated preterm infants. 9 38
11279743 2001
20
Effects of early inhaled beclomethasone therapy on tracheal aspirate inflammatory mediators IL-8 and IL-1ra in ventilated preterm infants at risk for bronchopulmonary dysplasia. 9 38
11015126 2000
21
An alternatively spliced surfactant protein B mRNA in normal human lung: disease implication. 9 38
10493923 1999
22
Hyperoxia induces thioredoxin and thioredoxin reductase gene expression in lungs of premature baboons with respiratory distress and bronchopulmonary dysplasia. 9 38
10424622 1999
23
Effect of oxygen on lung superoxide dismutase activities in premature baboons with bronchopulmonary dysplasia. 9 38
9887057 1999
24
Elevated interleukin-8 concentrations in amniotic fluid of mothers whose neonates subsequently develop bronchopulmonary dysplasia. 9 38
9605441 1998
25
L-selectin expression on polymorphonuclear leukocytes and monocytes in premature infants: reduced expression after dexamethasone treatment for bronchopulmonary dysplasia. 9 38
9470000 1998
26
Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia. 9 38
9407566 1997
27
Cromolyn sodium prophylaxis inhibits pulmonary proinflammatory cytokines in infants at high risk for bronchopulmonary dysplasia. 9 38
9372670 1997
28
Airway lesions and superoxide dismutase (SOD) distribution in bronchopulmonary dysplasia (BPD). 9 38
9642974 1997
29
Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. 9 38
9369827 1997
30
Eosinophil cationic protein in tracheal aspirates of preterm infants with bronchopulmonary dysplasia. 9 38
9202617 1997
31
Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. 9 38
8853062 1996
32
Elevated cytokine levels in tracheobronchial aspirate fluids from ventilator treated neonates with bronchopulmonary dysplasia. 9 38
8775225 1996
33
Use of the intramuscular relative-dose-response test to predict bronchopulmonary dysplasia in premature infants. 9 38
8604659 1996
34
Secretory leukocyte protease inhibitor and lung inflammation in developing bronchopulmonary dysplasia. 9 38
7913723 1994
35
Proteinase-antiproteinase balance in tracheal aspirates from neonates. 9 38
7909297 1994
36
Pulmonary endocrine cells in infancy and childhood. 9 38
2014192 1991
37
Plasma retinol-binding protein response to vitamin A administration in infants susceptible to bronchopulmonary dysplasia. 9 38
2108233 1990
38
Biophysical and chemical stability of surfactant/budesonide and the pulmonary distribution following intra-tracheal administration. 38
31204848 2019
39
Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial. 38
29695206 2019
40
Polysomnography for the management of oxygen supplementation therapy in infants with chronic lung disease of prematurity. 38
29695207 2019
41
CTGF: A potential therapeutic target for Bronchopulmonary dysplasia. 38
31377154 2019
42
Use of inhaled steroids to prevent bronchopulmonary dysplasia: a matter of great debate. 38
30498060 2019
43
Extended course of prednisolone in infants with severe bronchopulmonary dysplasia. 38
31265946 2019
44
Lung ultrasound score as early predictor of bronchopulmonary dysplasia in very low birth weight infants. 38
31216121 2019
45
Nasal Intermittent Mandatory Ventilation Versus Nasal Continuous Positive Airway Pressure Before and After Invasive Ventilatory Support. 38
31345544 2019
46
High frequency jet ventilation in preterm infants: experience from Western Australia. 38
29558222 2019
47
[Prostaglandin 12 analogs (epoprostenol and treprostinil) as a treatment for refractory bronchopulmonary dysplasia-induced pulmonary hypertension in an infant]. 38
31339286 2019
48
Phenotypic overlap in neonatal respiratory morbidity following preterm premature rupture of membranes versus spontaneous preterm labor. 38
31402735 2019
49
Perinatal factors associated with bubbly/cystic appearance in bronchopulmonary dysplasia: a nationwide, population-based cohort study in Japan. 38
31170848 2019
50
To compare nasal mask with binasal prongs in delivering continuous positive airway pressure for reducing need of invasive ventilation: randomized controlled trial. 38
31394955 2019

Variations for Bronchopulmonary Dysplasia

Expression for Bronchopulmonary Dysplasia

Search GEO for disease gene expression data for Bronchopulmonary Dysplasia.

Pathways for Bronchopulmonary Dysplasia

GO Terms for Bronchopulmonary Dysplasia

Cellular components related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 TIMP1 SOD1 SCGB1A1 RBP4 ITGAM IL1RN
2 extracellular region GO:0005576 9.7 TIMP1 SOD1 SFTPB SCGB1A1 RNASE3 RBP4
3 extracellular space GO:0005615 9.4 TIMP1 SOD1 SFTPB SCGB1A1 RNASE3 RBP4
4 secretory granule GO:0030141 9.33 SOD1 SCGB1A1 ELANE

Biological processes related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.78 SELL RNASE3 ITGAM ELANE
2 leukocyte migration GO:0050900 9.69 SELL ITGAM ELANE
3 response to lipopolysaccharide GO:0032496 9.63 SCGB1A1 FGF10 ELANE
4 chemotaxis GO:0006935 9.61 FLT1 FGF10 CXCL8
5 negative regulation of apoptotic process GO:0043066 9.52 TIMP1 SOD1
6 blood vessel morphogenesis GO:0048514 9.49 FLT1 FGF10
7 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.4 FLT1 FGF10
8 embryonic digestive tract development GO:0048566 9.37 FGF10 CXCL8
9 response to organic substance GO:0010033 9.33 TIMP1 SOD1 SCGB1A1
10 positive regulation of superoxide anion generation GO:0032930 9.32 SOD1 ITGAM
11 induction of positive chemotaxis GO:0050930 9.26 FGF10 CXCL8
12 cytokine-mediated signaling pathway GO:0019221 9.26 TIMP1 ITGAM IL1RN CXCL8
13 female genitalia morphogenesis GO:0048807 8.62 RBP4 FGF10

Molecular functions related to Bronchopulmonary Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 TIMP1 IL1RN CXCL8
2 heparin binding GO:0008201 9.13 SELL FGF10 ELANE
3 protease binding GO:0002020 8.8 TIMP1 SELL ELANE

Sources for Bronchopulmonary Dysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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