BPD
MCID: BRN056
MIFTS: 58

Bronchopulmonary Dysplasia (BPD)

Categories: Fetal diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Bronchopulmonary Dysplasia

MalaCards integrated aliases for Bronchopulmonary Dysplasia:

Name: Bronchopulmonary Dysplasia 52 58 54 37 62 71
Bpd 52 58

Characteristics:

Orphanet epidemiological data:

58
bronchopulmonary dysplasia
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare respiratory diseases
Developmental anomalies during embryogenesis


External Ids:

MESH via Orphanet 44 D001997
ICD10 via Orphanet 33 P27.1
UMLS via Orphanet 72 C0006287
Orphanet 58 ORPHA70589
UMLS 71 C0006287

Summaries for Bronchopulmonary Dysplasia

PubMed Health : 62 About bronchopulmonary dysplasia: Bronchopulmonary (BRONG-ko-PUL-mo-NAR-e) dysplasia (dis-PLA-ze-ah), or BPD, is a serious lung condition that affects infants. BPD mostly affects premature infants who need oxygen therapy (oxygen given through nasal prongs, a mask, or a breathing tube). Most infants who develop BPD are born more than 10 weeks before their due dates, weigh less than 2 pounds (about 1,000 grams) at birth, and have breathing problems. Infections that occur before or shortly after birth also can contribute to BPD. Some infants who have BPD may need long-term breathing support from nasal continuous positive airway pressure (NCPAP) machines or ventilators.

MalaCards based summary : Bronchopulmonary Dysplasia, also known as bpd, is related to idiopathic interstitial pneumonia and chorioamnionitis. An important gene associated with Bronchopulmonary Dysplasia is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are NF-KappaB Family Pathway and G-protein signaling RAC1 in cellular process. The drugs Procaterol and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include Lung, and related phenotypes are respiratory failure requiring assisted ventilation and emphysema

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 70589 Definition Bronchopulmonary dysplasia is a chronic respiratory disease that results from complications related to lung injury during the treatment of infant acute respiratory distress syndrome (see these terms) in low-birth-weight premature infants or from abnormal lung development in older infants. Clinical signs are tachypnea, tachycardia and signs of respiratory distress such as intercostal recession, grunting and nasal flaring. Visit the Orphanet disease page for more resources.

Wikipedia : 74 Bronchopulmonary dysplasia (BPD; formerly chronic lung disease of infancy) is a chronic lung disease in... more...

Related Diseases for Bronchopulmonary Dysplasia

Diseases related to Bronchopulmonary Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 278, show less)
# Related Disease Score Top Affiliating Genes
1 idiopathic interstitial pneumonia 30.9 SFTPB ELANE CXCL8
2 chorioamnionitis 30.7 IL1RN FLT1 ELANE CXCL8
3 gastroesophageal reflux 30.6 IL1RN ELANE CXCL8
4 pulmonary edema 30.5 SCGB1A1 FGF7 CXCL8
5 newborn respiratory distress syndrome 30.4 SFTPB SCGB1A1 FGF7 ELANE CXCL8
6 pre-eclampsia 30.4 SOD1 SELL FLT1 CXCL8
7 bronchopneumonia 30.2 ELANE CXCL8
8 pulmonary fibrosis 30.2 TIMP1 FGF7 ELANE CXCL8
9 pustulosis of palm and sole 30.2 IL1RN CXCL8
10 interstitial lung disease 30.2 TIMP1 SFTPB CXCL8
11 bronchiolitis obliterans 30.0 TIMP1 SCGB1A1 CXCL8
12 proteasome-associated autoinflammatory syndrome 1 29.9 SELL IL1RN ELANE CXCL8
13 bacterial sepsis 29.9 IL1RN ELANE CXCL8
14 bacterial infectious disease 29.9 SELL IL1RN ELANE CXCL8
15 adult respiratory distress syndrome 29.9 SFTPB FGF7 ELANE CXCL8
16 lung disease 29.9 TXN SOD1 SFTPB SCGB1A1 FGF7 ELANE
17 extrinsic allergic alveolitis 29.7 SOD1 SELL ELANE CXCL8
18 pneumonia 29.6 SFTPB SELL SCGB1A1 IL1RN ELANE CXCL8
19 respiratory failure 29.6 TIMP1 SOD1 SFTPB SCGB1A1 IL1RN ELANE
20 diaphragmatic hernia, congenital 29.6 SFTPB FGF7 FGF10
21 pulmonary emphysema 29.5 TIMP1 FGF7 ELANE CXCL8
22 pulmonary disease, chronic obstructive 29.0 TXN TIMP1 SFTPB SCGB1A1 ELANE CXCL8
23 asthma 28.8 TIMP1 SELL SCGB1A1 IL1RN ELANE CXCL8
24 cataract 28.6 TXN TIMP1 SOD1 IL1RN CXCL8
25 pulmonary fibrosis, idiopathic 27.3 TIMP1 SFTPB SCGB1A1 IL1RN FGF7 FGF10
26 borderline personality disorder 11.8
27 bipolar disorder 11.6
28 pulmonary hypertension, neonatal 11.3
29 bronchial disease 11.3
30 multiple personality disorder 11.2
31 pulmonary hypertension 10.9
32 personality disorder 10.9
33 patent ductus arteriosus 1 10.9
34 respiratory distress syndrome in premature infants 10.7
35 exudative vitreoretinopathy 1 10.7
36 cerebral palsy 10.6
37 enterocolitis 10.6
38 perinatal necrotizing enterocolitis 10.6
39 periventricular leukomalacia 10.5
40 pneumothorax 10.5
41 vascular disease 10.5
42 bronchiolitis 10.5
43 avoidant personality disorder 10.5
44 interstitial emphysema 10.4
45 toxicodendron dermatitis 10.4 SELL CXCL8
46 pouchitis 10.3 IL1RN CXCL8
47 paraquat lung 10.3 SFTPB SCGB1A1
48 hypercarotenemia and vitamin a deficiency, autosomal dominant 10.3
49 keratomalacia 10.3
50 cardiac rupture 10.3 ELANE CXCL8
51 yemenite deaf-blind hypopigmentation syndrome 10.3
52 toxic pneumonitis 10.3 SFTPB SCGB1A1
53 bone sarcoma 10.3 IL1RN CXCL8
54 pasteurellosis 10.3 ELANE CXCL8
55 pulmonary hypertension, primary, 1 10.3
56 sudden infant death syndrome 10.3
57 47,xyy 10.3
58 cytokine deficiency 10.3
59 sapho syndrome 10.3 IL1RN CXCL8
60 pulmonary vein stenosis 10.3
61 attention deficit-hyperactivity disorder 10.2
62 felty syndrome 10.2 ELANE CXCL8
63 arthus reaction 10.2 SELL ELANE
64 tracheomalacia 10.2
65 intestinal perforation 10.2
66 tricuspid valve insufficiency 10.2
67 48,xyyy 10.2
68 branchiootic syndrome 1 10.2
69 hydrops, lactic acidosis, and sideroblastic anemia 10.2
70 funisitis 10.2
71 rickets 10.2
72 hydrocephalus 10.2
73 heart septal defect 10.2
74 bronchiectasis 10.2
75 hypertrophic cardiomyopathy 10.2
76 cytomegalovirus infection 10.2
77 capillary leak syndrome 10.2 ELANE CXCL8
78 breast cancer 10.2
79 major affective disorder 8 10.2
80 major affective disorder 9 10.2
81 fibrosarcoma 10.2
82 mid-dermal elastolysis 10.2 TIMP1 ELANE
83 cryptogenic organizing pneumonia 10.2 TIMP1 CXCL8
84 aseptic meningitis 10.1 SOD1 IL1RN CXCL8
85 meconium aspiration syndrome 10.1 SFTPB SCGB1A1 CXCL8
86 atrial standstill 1 10.1
87 hypertriglyceridemia, familial 10.1
88 bronchomalacia 10.1
89 cystic fibrosis 10.1
90 bone disease 10.1
91 neonatal respiratory failure 10.1
92 anemia of prematurity 10.1
93 cholestasis 10.1
94 eclampsia 10.1
95 atrial heart septal defect 10.1
96 pulmonary immaturity 10.1
97 bronchitis 10.1
98 tracheobronchomalacia 10.1
99 hypoxia 10.1
100 apnea of prematurity 10.1
101 neovascular glaucoma 10.1 FLT1 CXCL8
102 mild pre-eclampsia 10.1 SOD1 FLT1
103 post-cardiac arrest syndrome 10.1 TXN CXCL8
104 pleurisy 10.1 SELL IL1RN CXCL8
105 blood group, globoside system 10.1 FLT1 CXCL8
106 status asthmaticus 10.1 IL1RN ELANE CXCL8
107 conjunctivochalasis 10.1 TIMP1 CXCL8
108 necrotizing fasciitis 10.1 IL1RN CXCL8
109 erysipelas 10.1 SOD1 IL1RN ELANE
110 macular retinal edema 10.1 FLT1 CXCL8
111 sexual sadism 10.1
112 sexual masochism 10.1
113 mental depression 10.1
114 rhabdomyosarcoma 10.1
115 depression 10.1
116 hair whorl 10.1
117 ige responsiveness, atopic 10.1
118 preterm premature rupture of the membranes 10.1
119 cyanosis, transient neonatal 10.1
120 muscle hypertrophy 10.1
121 deficiency anemia 10.1
122 chlamydia 10.1
123 hemosiderosis 10.1
124 oligohydramnios 10.1
125 placenta disease 10.1
126 respiratory distress syndrome, infant 10.1
127 specific language disorder 10.1
128 chronic granulomatous disease 10.1 SOD1 ELANE CXCL8
129 aspergillosis 10.1 IL1RN ELANE CXCL8
130 gingival disease 10.0 TIMP1 ELANE CXCL8
131 fibrosis of extraocular muscles, congenital, 1 10.0
132 strabismus 10.0
133 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
134 sandhoff disease 10.0
135 insulin-like growth factor i 10.0
136 body mass index quantitative trait locus 1 10.0
137 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
138 chorea, childhood-onset, with psychomotor retardation 10.0
139 sleep apnea 10.0
140 porencephaly 10.0
141 inguinal hernia 10.0
142 nephrocalcinosis 10.0
143 locked-in syndrome 10.0
144 quadriplegia 10.0
145 choreatic disease 10.0
146 severe pre-eclampsia 10.0
147 hypothyroidism 10.0
148 dermatitis 10.0
149 rhinitis 10.0
150 hypokalemia 10.0
151 neurotic disorder 10.0
152 influenza 10.0
153 mechanical strabismus 10.0
154 allergic asthma 10.0
155 refractive error 10.0
156 microcephaly 10.0
157 haemophilus influenzae 10.0
158 periodontal ehlers-danlos syndrome 10.0
159 stomatitis 10.0 IL1RN FGF7 CXCL8
160 lung giant cell carcinoma 10.0 TIMP1 CXCL8
161 venous insufficiency 9.9 TIMP1 SELL ELANE
162 alcohol dependence 9.9
163 optic atrophy with or without deafness, ophthalmoplegia, myopathy, ataxia, and neuropathy 9.9
164 ovarian cancer 9.9
165 prader-willi syndrome 9.9
166 chondrosarcoma 9.9
167 macular degeneration, age-related, 1 9.9
168 acromelic frontonasal dysostosis 9.9
169 bulimia nervosa 9.9
170 major depressive disorder 9.9
171 leptin deficiency or dysfunction 9.9
172 aspiration pneumonia 9.9
173 alexithymia 9.9
174 post-traumatic stress disorder 9.9
175 substance abuse 9.9
176 mood disorder 9.9
177 acute stress disorder 9.9
178 eating disorder 9.9
179 chronic pain 9.9
180 adult acute respiratory distress syndrome 9.9
181 behcet syndrome 9.9 SELL IL1RN CXCL8
182 relapsing-remitting multiple sclerosis 9.9 TIMP1 IL1RN CXCL8
183 pleural tuberculosis 9.9 TIMP1 CXCL8
184 kawasaki disease 9.9 TIMP1 SELL ELANE
185 bacterial pneumonia 9.9 SFTPB SCGB1A1 ELANE CXCL8
186 gingival overgrowth 9.9 TIMP1 FGF7 CXCL8
187 pneumoconiosis 9.9 SOD1 SCGB1A1 IL1RN CXCL8
188 clear cell acanthoma 9.8 FGF7 FGF10
189 microvascular complications of diabetes 1 9.8 TIMP1 FLT1 CXCL8
190 acanthoma 9.8 FGF7 FGF10
191 cardiomyopathy, familial hypertrophic, 2 9.8
192 laryngomalacia 9.8
193 otitis media 9.8
194 nephrolithiasis, calcium oxalate 9.8
195 pneumothorax, primary spontaneous 9.8
196 pulmonary hemosiderosis 9.8
197 retinoblastoma 9.8
198 sarcoidosis 1 9.8
199 triiodothyronine receptor auxiliary protein 9.8
200 cleft larynx, posterior 9.8
201 thymoma, familial 9.8
202 dysphasia, familial developmental 9.8
203 panbronchiolitis, diffuse 9.8
204 allergic rhinitis 9.8
205 anxiety 9.8
206 diabetes mellitus, ketosis-prone 9.8
207 lung cancer susceptibility 3 9.8
208 premature ovarian failure 7 9.8
209 periventricular nodular heterotopia 9.8
210 pain agnosia 9.8
211 specific language impairment 9.8
212 sensorineural hearing loss 9.8
213 berylliosis 9.8
214 glucose intolerance 9.8
215 spastic diplegia 9.8
216 spastic quadriplegia 9.8
217 pertussis 9.8
218 heart disease 9.8
219 gestational diabetes 9.8
220 patent foramen ovale 9.8
221 toxic shock syndrome 9.8
222 ventricular septal defect 9.8
223 hyperinsulinism 9.8
224 gastroenteritis 9.8
225 iron metabolism disease 9.8
226 agammaglobulinemia 9.8
227 bilirubin metabolic disorder 9.8
228 glycogen storage disease 9.8
229 acute interstitial pneumonia 9.8
230 lipid metabolism disorder 9.8
231 tracheal stenosis 9.8
232 thymoma 9.8
233 bacterial vaginosis 9.8
234 mastocytosis 9.8
235 placental insufficiency 9.8
236 hyperglycemia 9.8
237 milk allergy 9.8
238 neuromuscular disease 9.8
239 familial retinoblastoma 9.8
240 congestive heart failure 9.8
241 severe combined immunodeficiency 9.8
242 inherited metabolic disorder 9.8
243 polyhydramnios 9.8
244 measles 9.8
245 psoriasis 9.8
246 learning disability 9.8
247 tracheitis 9.8
248 hypereosinophilic syndrome 9.8
249 cantú syndrome and related disorders 9.8
250 flna-related periventricular nodular heterotopia 9.8
251 acute mountain sickness 9.8
252 congenital cytomegalovirus 9.8
253 cor triatriatum 9.8
254 dentinogenesis imperfecta type 2 9.8
255 diaphragmatic flutter 9.8
256 hypoadrenalism 9.8
257 lymphangiectasis 9.8
258 stenotrophomonas maltophilia infection 9.8
259 surfactant dysfunction 9.8
260 anoxia 9.8
261 autonomic dysfunction 9.8
262 dysphagia 9.8
263 rapidly involuting congenital hemangioma 9.8
264 pulmonary interstitial glycogenosis 9.8
265 rare hereditary hemochromatosis 9.8
266 rare pulmonary disease 9.8
267 hellp syndrome 9.8 TIMP1 FLT1 CXCL8
268 retinal vascular disease 9.8 TXN FLT1 CXCL8
269 periodontitis 9.7 TIMP1 IL1RN ELANE CXCL8
270 silicosis 9.7 TIMP1 SCGB1A1 IL1RN CXCL8
271 endophthalmitis 9.7 FLT1 CXCL8
272 eye disease 9.6 RBP4 IL1RN FLT1 CXCL8
273 diaphragm disease 9.6 SFTPB FGF10
274 arthritis 9.6 TIMP1 IL1RN FLT1 CXCL8
275 gastric adenocarcinoma 9.4 TIMP1 IL1RN FLT1 CXCL8
276 inflammatory bowel disease 9.1 TIMP1 SELL IL1RN FGF7 ELANE CXCL8
277 rheumatoid arthritis 9.1 TIMP1 SELL IL1RN FLT1 ELANE CXCL8
278 malaria 8.6 TXN TIMP1 SOD1 IL1RN FLT1 ELANE

Graphical network of the top 20 diseases related to Bronchopulmonary Dysplasia:



Diseases related to Bronchopulmonary Dysplasia

Symptoms & Phenotypes for Bronchopulmonary Dysplasia

Human phenotypes related to Bronchopulmonary Dysplasia:

58 31 (showing 22, show less)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 respiratory failure requiring assisted ventilation 58 31 hallmark (90%) Very frequent (99-80%) HP:0004887
2 emphysema 58 31 hallmark (90%) Very frequent (99-80%) HP:0002097
3 respiratory distress 58 31 hallmark (90%) Very frequent (99-80%) HP:0002098
4 cough 58 31 hallmark (90%) Very frequent (99-80%) HP:0012735
5 premature birth 58 31 hallmark (90%) Very frequent (99-80%) HP:0001622
6 small for gestational age 58 31 hallmark (90%) Very frequent (99-80%) HP:0001518
7 chronic lung disease 58 31 hallmark (90%) Very frequent (99-80%) HP:0006528
8 hyperoxemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012419
9 sleep disturbance 58 31 frequent (33%) Frequent (79-30%) HP:0002360
10 central apnea 58 31 frequent (33%) Frequent (79-30%) HP:0002871
11 exercise intolerance 58 31 frequent (33%) Frequent (79-30%) HP:0003546
12 diaphragmatic paralysis 58 31 frequent (33%) Frequent (79-30%) HP:0006597
13 wheezing 58 31 frequent (33%) Frequent (79-30%) HP:0030828
14 right ventricular hypertrophy 58 31 frequent (33%) Frequent (79-30%) HP:0001667
15 right ventricular failure 58 31 frequent (33%) Frequent (79-30%) HP:0001708
16 atelectasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100750
17 tracheobronchomalacia 58 31 occasional (7.5%) Occasional (29-5%) HP:0002786
18 pulmonary sequestration 58 31 occasional (7.5%) Occasional (29-5%) HP:0100632
19 dyspnea 58 Very frequent (99-80%)
20 functional respiratory abnormality 58 Frequent (79-30%)
21 abnormal lung morphology 58 Very frequent (99-80%)
22 abnormal respiratory system morphology 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Bronchopulmonary Dysplasia:

45 (showing 5, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ELANE FGF10 FGF7 FLT1 IL1RN RBP4
2 hematopoietic system MP:0005397 9.97 ELANE FGF10 FGF7 FLT1 IL1RN SCGB1A1
3 immune system MP:0005387 9.81 ELANE FGF10 FGF7 FLT1 IL1RN SCGB1A1
4 neoplasm MP:0002006 9.35 ELANE SCGB1A1 SELL SOD1 TIMP1
5 reproductive system MP:0005389 9.17 FGF10 FGF7 FLT1 IL1RN RBP4 SOD1

Drugs & Therapeutics for Bronchopulmonary Dysplasia

PubMed Health treatment related to Bronchopulmonary Dysplasia: 62

If your doctor thinks you're going to give birth too early, he or she may give you injections of a corticosteroid medicine. The medicine can speed up surfactant production in your baby. Surfactant is a liquid that coats the inside of the lungs . It helps keep the lungs open so your infant can breathe in air once he or she is born. Corticosteroids also can help your baby's lungs , brain , and kidneys develop more quickly while he or she is in the womb . Premature babies who have very low birth weights also might be given corticosteroids within the first few days of birth. Doctors sometimes prescribe inhaled nitric oxide shortly after birth for babies who have very low birth weights. This treatment can help improve the babies' lung function. These preventive measures may help reduce infants' risk of respiratory distress syndrome (RDS), which can lead to BPD.

Drugs for Bronchopulmonary Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 193, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Procaterol Approved, Investigational Phase 4 72332-33-3 688561
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3
Zinc Approved, Investigational Phase 4 7440-66-6 32051
4
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
5
Zinc sulfate Approved, Investigational Phase 4 7733-02-0
6
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
7 Vitamins Phase 4
8 Calciferol Phase 4
9 Antibodies Phase 4
10 Immunoglobulins Phase 4
11 Immunologic Factors Phase 4
12 Lactoferrin Phase 4
13 Vaccines Phase 4
14 Anti-Infective Agents Phase 4
15 Anti-Bacterial Agents Phase 4
16 Hormone Antagonists Phase 4
17 Hormones Phase 4
18 Anti-Inflammatory Agents Phase 4
19 glucocorticoids Phase 4
20 Trace Elements Phase 4
21 Micronutrients Phase 4
22 Nutrients Phase 4
23 Antibiotics, Antitubercular Phase 4
24 Gentamicins Phase 4
25 Antitubercular Agents Phase 4
26 Astringents Phase 4
27 Dermatologic Agents Phase 4
28
Clarithromycin Approved Phase 3 81103-11-9 84029
29
Furosemide Approved, Vet_approved Phase 2, Phase 3 54-31-9 3440
30
Spironolactone Approved Phase 2, Phase 3 52-01-7, 1952-01-7 5833
31
Chlorothiazide Approved, Vet_approved Phase 2, Phase 3 58-94-6 2720
32
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
33
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
34 Prednisolone acetate Approved, Vet_approved Phase 3 52-21-1
35
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
36
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
37
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
38
Calfactant Approved Phase 3 183325-78-2
39
Palivizumab Approved, Investigational Phase 2, Phase 3 188039-54-5
40
Nitrous oxide Approved, Vet_approved Phase 3 10024-97-2 948
41
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
42
Acetylcysteine Approved, Investigational Phase 2, Phase 3 616-91-1 12035
43
Ethanol Approved Phase 3 64-17-5 702
44
Benzyl alcohol Approved Phase 3 100-51-6 244
45
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
46
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
47
Cysteine Approved, Nutraceutical Phase 2, Phase 3 52-90-4 5862
48
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3 50-14-6 5280793
49
Vitamin D3 Approved, Nutraceutical Phase 2, Phase 3 67-97-0 6221 5280795
50
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
51
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
52
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
53 Tocotrienol Investigational Phase 3 6829-55-6
54 Cytochrome P-450 CYP3A Inhibitors Phase 3
55 Cytochrome P-450 Enzyme Inhibitors Phase 3
56 Mineralocorticoid Receptor Antagonists Phase 2, Phase 3
57 Mineralocorticoids Phase 2, Phase 3
58 Diuretics, Potassium Sparing Phase 2, Phase 3
59 Methylprednisolone Acetate Phase 3
60 Neuroprotective Agents Phase 3
61
Beclomethasone Phase 3 4419-39-0 20469
62 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
63 Analgesics, Non-Narcotic Phase 3
64 Analgesics Phase 3
65 Cyclooxygenase Inhibitors Phase 2, Phase 3
66 Antirheumatic Agents Phase 2, Phase 3
67 Anesthetics, General Phase 3
68 Anesthetics, Inhalation Phase 3
69 Antibodies, Monoclonal Phase 3
70 Immunoglobulin G Phase 3
71 Ergocalciferols Phase 2, Phase 3
72 Vitamin D2 Phase 2, Phase 3
73 Protective Agents Phase 2, Phase 3
74 Free Radical Scavengers Phase 2, Phase 3
75 Antioxidants Phase 2, Phase 3
76 Antiviral Agents Phase 2, Phase 3
77 Retinol palmitate Phase 3
78 retinol Phase 3
79 Tocopherols Phase 3
80 Tocotrienols Phase 3
81 N-monoacetylcystine Phase 2, Phase 3
82 Antidotes Phase 2, Phase 3
83 Expectorants Phase 2, Phase 3
84 Hydrocortisone-17-butyrate Phase 3
85 HIV Protease Inhibitors Phase 3
86 Antiemetics Phase 3
87
protease inhibitors Phase 3
88 Gastrointestinal Agents Phase 3
89 BB 1101 Phase 3
90 Antineoplastic Agents, Hormonal Phase 3
91 Natriuretic Agents Phase 3
92 diuretics Phase 3
93 Acidophilus Phase 3
94
Montelukast Approved Phase 2 158966-92-8 5281040
95
Cefotaxime Approved Phase 2 63527-52-6 456256 5742673
96
Cefoxitin Approved Phase 2 35607-66-0 441199
97
Mecasermin Approved, Investigational Phase 2 68562-41-4
98
Acetaminophen Approved Phase 2 103-90-2 1983
99
Caffeine Approved Phase 2 58-08-2 2519
100
Azithromycin Approved Phase 2 83905-01-5 447043 55185
101
Fludrocortisone Approved, Investigational Phase 2 127-31-1 31378
102 Poractant alfa Approved Phase 2 129069-19-8
103 Beractant Approved Phase 2 108778-82-1
104
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
105
Meclocycline Investigational Phase 2 2013-58-3 5480760
106 Leukotriene Antagonists Phase 2
107 Vitamin B Complex Phase 2
108 Vitamin B9 Phase 2
109 Folate Phase 2
110 Insulin, Globin Zinc Phase 2
111 insulin Phase 2
112 Mitogens Phase 2
113 Hematinics Phase 2
114 Epoetin alfa Phase 2 113427-24-0
115 Sildenafil Citrate Phase 2 171599-83-0
116 Phosphodiesterase 5 Inhibitors Phase 2
117 Phosphodiesterase Inhibitors Phase 2
118 Pharmaceutical Solutions Phase 2
119 Antipyretics Phase 2
120 Central Nervous System Stimulants Phase 2
121 Tin Fluorides Phase 2
122 Sodium Potassium Chloride Symporter Inhibitors Phase 2
123 Pulmonary Surfactants Phase 2
124 Respiratory System Agents Phase 2
125 Calamus Phase 2
126
Hydrocortisone Approved, Vet_approved Phase 1 50-23-7 5754
127
Hydrocortisone acetate Approved, Vet_approved Phase 1 50-03-3
128
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 1 437-38-7 3345
129
Atropine Approved, Vet_approved Phase 1 51-55-8, 5908-99-6 174174
130 Perflubron Investigational Phase 1 423-55-2
131 Xenon Experimental Phase 1 7440-63-3
132 Anticonvulsants Phase 1
133 Anti-Obesity Agents Phase 1
134 Bromides Phase 1
135 Hydrocortisone 17-butyrate 21-propionate Phase 1
136 Hydrocortisone hemisuccinate Phase 1
137 Anesthetics, Intravenous Phase 1
138 Cholinergic Agents Phase 1
139 Anti-Arrhythmia Agents Phase 1
140 Narcotics Phase 1
141 Adjuvants, Anesthesia Phase 1
142 Muscarinic Antagonists Phase 1
143 Parasympatholytics Phase 1
144 Analgesics, Opioid Phase 1
145 Cholinergic Antagonists Phase 1
146 Mydriatics Phase 1
147
Arginine Investigational, Nutraceutical Phase 1 74-79-3 6322
148
Ketamine Approved, Vet_approved 6740-88-1 3821
149
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
150
Nicotine Approved 54-11-5 942 89594
151
Midazolam Approved, Illicit 59467-70-8 4192