MCID: BRN120
MIFTS: 42

Bronchus Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Bronchus Cancer

MalaCards integrated aliases for Bronchus Cancer:

Name: Bronchus Cancer 12 15
Bronchial Neoplasms 44 73
Bronchus Carcinoma 12 15
Bronchial Neoplasm 12 15
Malignant Neoplasm of Bronchus and Lung 12
Malignant Neoplasm of Bronchus or Lung 12
Bc - Bronchogenic Carcinoma 12
Carcinoma, Bronchogenic 44
Bronchogenic Carcinoma 73
Neoplasm of Bronchus 12
Bronchus Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1325 DOID:3904 DOID:3906
ICD10 33 C34 C34.9
ICD9CM 35 162.9
NCIt 50 C35875

Summaries for Bronchus Cancer

Disease Ontology : 12 A bronchus cancer that has material basis in epithelial cells.

MalaCards based summary : Bronchus Cancer, also known as bronchial neoplasms, is related to small cell cancer of the lung and main bronchus cancer, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Bronchus Cancer is SAA1 (Serum Amyloid A1), and among its related pathways/superpathways are Neuroscience and Interleukin-4 and 13 signaling. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and thyroid.

Related Diseases for Bronchus Cancer

Diseases in the Bronchus Cancer family:

Bronchus Carcinoma in Situ

Diseases related to Bronchus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 small cell cancer of the lung 30.2 AVP ENO2 POMC
2 main bronchus cancer 12.3
3 bronchus carcinoma in situ 12.1
4 lung cancer 11.2
5 bronchus mucoepidermoid carcinoma 11.1
6 pulmonary blastoma 10.7
7 pleuropulmonary blastoma type 1 10.7
8 pleuropulmonary blastoma type 2 10.7
9 pleuropulmonary blastoma type 3 10.7
10 pleuropulmonary blastoma 10.6
11 well-differentiated fetal adenocarcinoma of the lung 10.6
12 fetal erythroblastosis 10.1 POMC SAA1
13 central nervous system germinoma 10.1 AVP POMC
14 tuberculous epididymitis 10.1 AVP POMC
15 hyper-igd syndrome 10.1 CRP SAA1
16 central nervous system germ cell tumor 10.1 AVP POMC
17 inappropriate adh syndrome 10.1 AVP POMC
18 secondary hypertrophic osteoarthropathy 10.1 AVP POMC
19 amyloidosis aa 10.1 CRP SAA1
20 syndrome of inappropriate antidiuretic hormone 10.0 AVP POMC
21 diabetes insipidus 10.0 AVP POMC
22 diabetes insipidus, neurohypophyseal 10.0 AVP POMC
23 premenstrual tension 10.0 AVP POMC
24 chromophobe adenoma 10.0 AVP POMC
25 paralytic ileus 10.0 AVP CRP
26 rheumatic myocarditis 10.0 CRP POMC
27 dental abscess 10.0 AVP CRP
28 sphenoid sinusitis 10.0 AVP CRP
29 pituitary hormone deficiency, combined, 2 10.0 AVP POMC
30 brucellosis 10.0 CRP SAA1
31 peripheral vertigo 10.0 AVP CRP
32 granulomatous angiitis 10.0 AVP CRP
33 pituitary gland disease 10.0 AVP POMC
34 analbuminemia 10.0 AVP CRP
35 familial mediterranean fever 10.0 CRP SAA1
36 finger agnosia 10.0 CD6 ENO2
37 supraglottis cancer 10.0 CD6 ENO2
38 bronchiectasis 10.0
39 lymphocytic hypophysitis 10.0 ENO2 POMC
40 acute thyroiditis 9.9 ENO2 POMC
41 malignant teratoma 9.9 AVP ENO2
42 overnutrition 9.9 CRP POMC
43 cloacogenic carcinoma 9.9 ENO2 POMC
44 glucose metabolism disease 9.9 CRP POMC
45 actinomycosis 9.9
46 tracheal cancer 9.9 AVP ENO2
47 acquired metabolic disease 9.9 CRP POMC
48 adrenal rest tumor 9.9 ENO2 POMC
49 aortic valve disease 1 9.9 CRP POMC
50 dysentery 9.9 CRP ENO2

Graphical network of the top 20 diseases related to Bronchus Cancer:



Diseases related to Bronchus Cancer

Symptoms & Phenotypes for Bronchus Cancer

UMLS symptoms related to Bronchus Cancer:


fever, dyspnea, hemoptysis, coughing

Drugs & Therapeutics for Bronchus Cancer

Drugs for Bronchus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 3
3 Coagulants Phase 3
4 Hemostatics Phase 3
5
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
6
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
7
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
8 Protein Kinase Inhibitors Phase 2
9 Bendamustine Hydrochloride Phase 2
10 Alkylating Agents Phase 2
11 Antineoplastic Agents, Alkylating Phase 2
12 Anti-Inflammatory Agents Phase 2
13 Anti-Allergic Agents Phase 2
14 Peripheral Nervous System Agents Phase 2
15 Bronchodilator Agents Phase 2
16 Respiratory System Agents Phase 2
17 Autonomic Agents Phase 2
18 Dermatologic Agents Phase 2,Phase 1
19 Anti-Asthmatic Agents Phase 2
20 Antioxidants Phase 2
21 Antiviral Agents Phase 2
22 Protective Agents Phase 2
23 Free Radical Scavengers Phase 2
24 Expectorants Phase 2
25 Anti-Infective Agents Phase 2
26 Antidotes Phase 2
27 N-monoacetylcystine Phase 2
28 Hematoporphyrin Derivative Phase 1
29 Photosensitizing Agents Phase 1
30 Hematoporphyrins Phase 1

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis Unknown status NCT01496196 Phase 3 tranexamic acid;tranexamic acid
2 Comparing Diagnostic Yield Between R-EBUS Guided Cryo Biopsy Vs. CT Guided Biopsy for PPL Unknown status NCT02395939 Phase 3
3 A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST) Completed NCT00652769 Phase 3
4 Efficacy and Safety Study of Gefitinib in Squamous NSCLC Patients Who Failed First-Line Chemotherapy Unknown status NCT01485809 Phase 2 Gefitinib
5 Study to Determine the Efficacy of Bendamustin in Patients With Recurrent Small Cell Lung Cancer (SCLC) Unknown status NCT00168922 Phase 2 Bendamustin/Ribomustin
6 Randomized Trial of Fluticasone in Bronchial Premalignancy Completed NCT00407264 Phase 2 Fluticasone propionate
7 Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training Completed NCT00196885 Phase 2 N-acetylcysteine
8 Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer Completed NCT00014066 Phase 1 hematoporphyrin derivative
9 Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer Completed NCT00526461 Phase 1 HPPH
10 Diagnostic Effectiveness of Virtual Bronchoscopy Completed NCT00001515 Phase 1
11 SAS in Patients With Bronchial Carcinoma Unknown status NCT02270853 Not Applicable
12 Prevalence of Sleep-disordered Breathing in Patients With a Newly Diagnosed Non Small Cell Lung Cancer Unknown status NCT02648087 Not Applicable
13 Study of the Quality of Lung Resection Unknown status NCT02877043
14 Feasibility of the Research for Mutation of K-ras and EGFR in CTCs From Metastatic Non Small Cells Bronchial Carcinomas Completed NCT01380795 Early Phase 1
15 Ultra-Violet Fluorescence Bronchial Cancer Location Completed NCT02533518 Not Applicable
16 Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT Completed NCT01261585
17 Tumour Registry Lung Cancer (TLK) Completed NCT01192919
18 Sensory Approach of Food Modifications Led by Chemotherapy Completed NCT02368509 Not Applicable
19 Evolution of Indications for Transbronchial Ganglionic Ultrasound Completed NCT03132883
20 A Coordination Card of Care Relative to the Medicinal Treatments Got Out of it From Hospitalization Completed NCT03293966
21 Siemens VOC TB Pilot Study Completed NCT01748357
22 Evaluation of a LAM FLISA for the Diagnosis of Tuberculosis Completed NCT01587677
23 Rehabilitation by Effort for Patients With Advanced Bronchial Cancer Recruiting NCT03684486 Not Applicable
24 Whole Body Electromyostimulation and Nutritional Therapy for Patients With Esophageal and Bronchial Carcinoma Recruiting NCT03274349 Not Applicable
25 Kinetics of Circulating Tumoral Cells in Bronchial Primitive Cancer Recruiting NCT03328559 Not Applicable
26 Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers Recruiting NCT00188890
27 Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease Active, not recruiting NCT00784329 Not Applicable
28 Feasibility of Immunotherapy Administration to Patients With Bronchial Cancer in a Hospital-at- Home Setting (ImHADom) Not yet recruiting NCT03786653

Search NIH Clinical Center for Bronchus Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: bronchial neoplasms

Genetic Tests for Bronchus Cancer

Anatomical Context for Bronchus Cancer

MalaCards organs/tissues related to Bronchus Cancer:

41
Lung, Testes, Thyroid, Pituitary, Pancreas, Cervix

Publications for Bronchus Cancer

Articles related to Bronchus Cancer:

(show all 19)
# Title Authors Year
1
Updated statistics of lung and bronchus cancer in United States (2018). ( 29708136 )
2018
2
Regional variation in lung and bronchus cancer survival in the US using mortality-to-incidence ratios. ( 30390926 )
2018
3
Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. ( 27685944 )
2016
4
Incidence rates for lung and bronchus cancer of Japanese in Japan and in the United States from the Cancer Incidence in Five Continents. ( 27380807 )
2016
5
Stat Bite Percentage of New Caces by Age Group For Lung and Bronchus Cancer (2008-2012). ( 26944763 )
2016
6
Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer. ( 27605630 )
2016
7
Lung and bronchus cancer in Puerto Rico: changes in incidence and mortality rates by histology and sex during 1987-2003: comment on the article by Rivas et al. ( 22783701 )
2012
8
Lung and bronchus cancer in Puerto Rico: changes in incidence and mortality rates by histology and sex during 1987-2003. ( 22263297 )
2011
9
Superior vena cava syndrome in a man with situs inversus totalis and left main bronchus cancer. ( 19507488 )
2009
10
Lung and bronchus cancer disparities in South Carolina: epidemiology and strategies for prevention. ( 17319229 )
2006
11
Stat bite: Mortality from lung and bronchus cancer by race/ethnicity, 1998-2002. ( 16449672 )
2006
12
Stat bite: Incidence of lung and bronchus cancer by ethnicity, 1996-2000. ( 12902435 )
2003
13
Lung and bronchus cancer in women: a 21st-century epidemic. ( 12370622 )
2002
14
Kawan bronchial brush/cell block technique. Facilitation of the routine diagnosis of bronchial neoplasms. ( 9850651 )
1998
15
Short-term anesthesia with midazolam and flumazenil during intraluminal afterloading of esophageal and bronchial neoplasms in ill, inoperable patients. ( 1692282 )
1990
16
Letter: Surgery of bronchial neoplasms. ( 1212009 )
1975
17
Bronchial neoplasms and hormonal secretions. ( 6017519 )
1967
18
Attempted long-term culture of human bronchial mucosa and bronchial neoplasms. ( 13665331 )
1959
19
Bronchial neoplasms among the Ceylonese. ( 13536207 )
1958

Variations for Bronchus Cancer

Cosmic variations for Bronchus Cancer:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10779 TP53 lung,bronchus,carcinoma,NS c.818G>T p.R273L 17:7673802-7673802 14
2 COSM10656 TP53 lung,bronchus,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 14
3 COSM10660 TP53 lung,bronchus,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 14
4 COSM10718 TP53 lung,bronchus,carcinoma,NS c.524G>T p.R175L 17:7675088-7675088 14
5 COSM10662 TP53 lung,bronchus,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 14
6 COSM6213 EGFR lung,bronchus,carcinoma,NS c.2582T>A p.L861Q 7:55191831-55191831 14

Expression for Bronchus Cancer

Search GEO for disease gene expression data for Bronchus Cancer.

Pathways for Bronchus Cancer

Pathways related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 AVP ENO2 POMC
2 11.21 POMC SAA1
3
Show member pathways
10.1 CRP POMC

GO Terms for Bronchus Cancer

Cellular components related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 AVP CD6 CRP POMC SAA1
2 secretory granule GO:0030141 9.16 AVP POMC
3 extracellular space GO:0005615 9.02 AVP CRP ENO2 POMC SAA1

Biological processes related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.33 CD6 CRP SAA1
2 generation of precursor metabolites and energy GO:0006091 8.96 AVP POMC
3 acute-phase response GO:0006953 8.62 CRP SAA1

Molecular functions related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.96 AVP POMC
2 G protein-coupled receptor binding GO:0001664 8.62 POMC SAA1

Sources for Bronchus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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