MCID: BRN120
MIFTS: 51

Bronchus Cancer

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Bronchus Cancer

MalaCards integrated aliases for Bronchus Cancer:

Name: Bronchus Cancer 12 15
Bronchogenic Carcinoma 17 74
Bronchus Carcinoma 12 15
Malignant Neoplasm of Bronchus and Lung 12
Malignant Neoplasm of Bronchus or Lung 12
Bc - Bronchogenic Carcinoma 12
Carcinoma, Bronchogenic 45
Bronchial Neoplasms 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1325 DOID:3904
ICD9CM 36 162.9
MeSH 45 D002283
NCIt 51 C35875
ICD10 34 C34 C34.9

Summaries for Bronchus Cancer

Disease Ontology : 12 A bronchus cancer that has material basis in epithelial cells.

MalaCards based summary : Bronchus Cancer, also known as bronchogenic carcinoma, is related to inappropriate adh syndrome and small cell cancer of the lung, and has symptoms including fever, dyspnea and hemoptysis. An important gene associated with Bronchus Cancer is SAA1 (Serum Amyloid A1), and among its related pathways/superpathways are Advanced glycosylation endproduct receptor signaling and Estrogen Receptor Pathway. The drugs Tranexamic Acid and Antifibrinolytic Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, lymph node and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Bronchus Cancer

Diseases in the Bronchus Cancer family:

Bronchus Carcinoma in Situ

Diseases related to Bronchus Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 inappropriate adh syndrome 30.3 AVP AVPR2
2 small cell cancer of the lung 30.1 AVP CEACAM5 ENO2 KRT19
3 main bronchus cancer 12.3
4 bronchus carcinoma in situ 12.2
5 lung cancer 11.2
6 bronchus mucoepidermoid carcinoma 11.2
7 pulmonary blastoma 10.7
8 pleuropulmonary blastoma type 1 10.7
9 pleuropulmonary blastoma type 2 10.7
10 pleuropulmonary blastoma type 3 10.7
11 pleuropulmonary blastoma 10.7
12 well-differentiated fetal adenocarcinoma of the lung 10.7
13 sclerosing cholangitis, neonatal 10.5
14 finger agnosia 10.4 CD6 ENO2
15 hyper-igd syndrome 10.4 CRP SAA1
16 paralytic ileus 10.4 AVP CRP
17 lung oat cell carcinoma 10.4 AVP ENO2
18 nephrogenic syndrome of inappropriate antidiuresis 10.4 AVP AVPR2
19 dental abscess 10.4 AVP CRP
20 epulis 10.4 ENO2 PGR
21 malignant teratoma 10.4 AVP ENO2
22 lung meningioma 10.4 ENO2 PGR
23 sphenoid sinusitis 10.4 AVP CRP
24 olfactory nerve neoplasm 10.4 AVP ENO2
25 supraglottis cancer 10.4 CD6 ENO2
26 amyloidosis aa 10.4 CRP SAA1
27 goblet cell carcinoid 10.3 CEACAM7 ENO2
28 impaired renal function disease 10.3 AVP AVPR2
29 polyradiculopathy 10.3 AVPR2 CD6
30 pleural empyema 10.3
31 pneumonia 10.3
32 mammographic density 10.3 CYP1A1 PGR
33 melanotic medulloblastoma 10.3 CEACAM5 ENO2
34 gallbladder squamous cell carcinoma 10.3 APP CEACAM5
35 atypical follicular adenoma 10.2 CEACAM5 ENO2
36 nervous system disease 10.2 APP CRP ENO2
37 conn's syndrome 10.2
38 degos 'en cocarde' erythrokeratoderma 10.2
39 granulomatous endometritis 10.2 CEACAM5 PGR
40 tuberculous empyema 10.2 AVPR2 CEACAM5
41 intracystic papillary adenoma 10.2 CEACAM5 PGR
42 breast mucoepidermoid carcinoma 10.2 CEACAM5 PGR
43 esophageal adenosquamous carcinoma 10.2 CEACAM5 JUN
44 neuropathy 10.2
45 in situ carcinoma 10.2
46 diabetes insipidus 10.2
47 rete testis adenocarcinoma 10.2 CEACAM5 ENO2
48 adenoid basal cell carcinoma 10.2 CEACAM5 PGR
49 pancreatic serous cystadenoma 10.2 CEACAM5 PGR
50 syndrome of inappropriate antidiuretic hormone 10.2 AVP AVPR2

Graphical network of the top 20 diseases related to Bronchus Cancer:



Diseases related to Bronchus Cancer

Symptoms & Phenotypes for Bronchus Cancer

UMLS symptoms related to Bronchus Cancer:


fever, dyspnea, hemoptysis, coughing

GenomeRNAi Phenotypes related to Bronchus Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.28 AVPR2 CEACAM7 SAA1
2 Decreased viability GR00381-A-3 9.28 AVPR2 CEACAM7 SAA1
3 Decreased viability GR00402-S-2 9.28 AVPR2 CEACAM7 SAA1

MGI Mouse Phenotypes related to Bronchus Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.1 APP AVP CYP1A1 JUN KRT19 PGR

Drugs & Therapeutics for Bronchus Cancer

Drugs for Bronchus Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2 Antifibrinolytic Agents Phase 3
3 Hemostatics Phase 3
4 Coagulants Phase 3
5
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
6
Fluticasone Approved, Experimental Phase 2 90566-53-3 62924
7
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
8 Protein Kinase Inhibitors Phase 2
9 Bendamustine Hydrochloride Phase 2
10 Alkylating Agents Phase 2
11 Antineoplastic Agents, Alkylating Phase 2
12 Peripheral Nervous System Agents Phase 2
13 Dermatologic Agents Phase 2,Phase 1
14 Anti-Inflammatory Agents Phase 2
15 Respiratory System Agents Phase 2
16 Anti-Asthmatic Agents Phase 2
17 Bronchodilator Agents Phase 2
18 Autonomic Agents Phase 2
19 Anti-Allergic Agents Phase 2
20 Expectorants Phase 2
21 Antioxidants Phase 2
22 Anti-Infective Agents Phase 2
23 Free Radical Scavengers Phase 2
24 Antiviral Agents Phase 2
25 Antidotes Phase 2
26 Protective Agents Phase 2
27 N-monoacetylcystine Phase 2
28 Hematoporphyrin Derivative Phase 1
29 Photosensitizing Agents Phase 1
30 Hematoporphyrins Phase 1

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 The Role of Inhalations of Tranexamic Acid in Patients With Hemoptysis Unknown status NCT01496196 Phase 3 tranexamic acid;tranexamic acid
2 Comparing Diagnostic Yield Between R-EBUS Guided Cryo Biopsy Vs. CT Guided Biopsy for PPL Unknown status NCT02395939 Phase 3
3 A New Pathway With BronchOscopic or Oesophageal Ultrasound for Lung Cancer Diagnosis and STaging (BOOST) Completed NCT00652769 Phase 3
4 Efficacy and Safety Study of Gefitinib in Squamous NSCLC Patients Who Failed First-Line Chemotherapy Unknown status NCT01485809 Phase 2 Gefitinib
5 Study to Determine the Efficacy of Bendamustin in Patients With Recurrent Small Cell Lung Cancer (SCLC) Unknown status NCT00168922 Phase 2 Bendamustin/Ribomustin
6 Randomized Trial of Fluticasone in Bronchial Premalignancy Completed NCT00407264 Phase 2 Fluticasone propionate
7 Effect of an Antioxidant on Cancer-Cachectic Patients Undergoing Exercise Training Completed NCT00196885 Phase 2 N-acetylcysteine
8 Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer Completed NCT00014066 Phase 1 hematoporphyrin derivative
9 Photodynamic Therapy Using HPPH in Treating Patients With Stage 0 Non-Small Cell Lung Cancer Completed NCT00526461 Phase 1 HPPH
10 Diagnostic Effectiveness of Virtual Bronchoscopy Completed NCT00001515 Phase 1
11 SAS in Patients With Bronchial Carcinoma Unknown status NCT02270853 Not Applicable
12 Prevalence of Sleep-disordered Breathing in Patients With a Newly Diagnosed Non Small Cell Lung Cancer Unknown status NCT02648087 Not Applicable
13 Study of the Quality of Lung Resection Unknown status NCT02877043
14 Feasibility of the Research for Mutation of K-ras and EGFR in CTCs From Metastatic Non Small Cells Bronchial Carcinomas Completed NCT01380795 Early Phase 1
15 Ultra-Violet Fluorescence Bronchial Cancer Location Completed NCT02533518 Not Applicable
16 Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT Completed NCT01261585
17 Tumour Registry Lung Cancer (TLK) Completed NCT01192919
18 Sensory Approach of Food Modifications Led by Chemotherapy Completed NCT02368509 Not Applicable
19 Evolution of Indications for Transbronchial Ganglionic Ultrasound Completed NCT03132883
20 A Coordination Card of Care Relative to the Medicinal Treatments Got Out of it From Hospitalization Completed NCT03293966
21 Siemens VOC TB Pilot Study Completed NCT01748357
22 Evaluation of a LAM FLISA for the Diagnosis of Tuberculosis Completed NCT01587677
23 Feasibility of Immunotherapy Administration to Patients With Bronchial Cancer in a Hospital-at- Home Setting (ImHADom) Recruiting NCT03786653
24 Rehabilitation by Effort for Patients With Advanced Bronchial Cancer Recruiting NCT03684486 Not Applicable
25 Whole Body Electromyostimulation and Nutritional Therapy for Patients With Esophageal and Bronchial Carcinoma Recruiting NCT03274349 Not Applicable
26 Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers Recruiting NCT00188890
27 Kinetics of Circulating Tumoral Cells in Bronchial Primitive Cancer Active, not recruiting NCT03328559 Not Applicable
28 Pilot Study To Evaluate Optical Frequency Domain Imaging For Diagnosis Of Central Airway Disease Withdrawn NCT00784329 Not Applicable

Search NIH Clinical Center for Bronchus Cancer

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: carcinoma, bronchogenic

Genetic Tests for Bronchus Cancer

Anatomical Context for Bronchus Cancer

MalaCards organs/tissues related to Bronchus Cancer:

42
Lung, Lymph Node, Breast, Bone, Thyroid, Brain, Testes

Publications for Bronchus Cancer

Articles related to Bronchus Cancer:

(show top 50) (show all 2105)
# Title Authors Year
1
Erratum to updated statistics of lung and bronchus cancer in United States (2018). ( 31019804 )
2019
2
A Preliminary Study of Microbiota Diversity in Saliva and Bronchoalveolar Lavage Fluid from Patients with Primary Bronchogenic Carcinoma. ( 30994108 )
2019
3
Updated statistics of lung and bronchus cancer in United States (2018). ( 29708136 )
2018
4
Regional variation in lung and bronchus cancer survival in the US using mortality-to-incidence ratios. ( 30390926 )
2018
5
Remission of nephrotic syndrome after surgical intervention for bronchogenic carcinoma: the 10-year follow-up of a patient with membranous nephropathy. ( 30104905 )
2018
6
Melittin Induced G1 Cell Cycle Arrest and Apoptosis in Chago-K1 Human Bronchogenic Carcinoma Cells and Inhibited the Differentiation of THP-1 Cells into Tumour- Associated Macrophages ( 30583665 )
2018
7
ADVANCED BRONCHOGENIC CARCINOMA PRESENTING WITH SKIN NODULES - A CASE REPORT. ( 30899705 )
2018
8
Influence of nodal status on the surgical outcome for bronchogenic carcinoma involving the carina: a systematic review and meta-analysis. ( 28565890 )
2018
9
DIABETES INSIPIDUS IN A PATIENT WITH BRONCHOGENIC CARCINOMA AND SECONDARIES TO THE HYPOTHALAMUS - CASE REPORT. ( 30525006 )
2017
10
Assessment of thoracic vasculature in patients with central bronchogenic carcinoma by unenhanced magnetic resonance angiography: comparison between 2D free-breathing TrueFISP, 2D breath-hold TrueFISP and 3D respiratory-triggered SPACE. ( 28740677 )
2017
11
The usefulness of thoracic ultrasonography in diagnosis and staging of bronchogenic carcinoma. ( 29163656 )
2017
12
Paraneoplastic Inverse Myasthenic Syndrome as a Presentation of Bronchogenic Carcinoma. ( 29313588 )
2017
13
Metastasis to parotid gland from primary bronchogenic carcinoma: A case letter. ( 28671178 )
2017
14
All That Glitters Is Not Gold" - A Case of an Occult Foreign Body in the Lung with Elevated 2-[18F]-Fluoro-2-deoxy-D-glucose (FDG) Uptake Mimicking Bronchogenic Carcinoma. ( 28265526 )
2017
15
Bronchogenic Carcinoma with Cardiac Invasion Simulating Acute Myocardial Infarction. ( 27042370 )
2016
16
Incidence rates for lung and bronchus cancer of Japanese in Japan and in the United States from the Cancer Incidence in Five Continents. ( 27380807 )
2016
17
Dosimetric impact of an air passage on intraluminal brachytherapy for bronchus cancer. ( 27605630 )
2016
18
Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. ( 27685944 )
2016
19
A Phase I Study of Light Dose for Photodynamic Therapy Using 2-[1-Hexyloxyethyl]-2 Devinyl Pyropheophorbide-a for the Treatment of Non-Small Cell Carcinoma In Situ or Non-Small Cell Microinvasive Bronchogenic Carcinoma: A Dose Ranging Study. ( 26718878 )
2016
20
Video-assisted thoracoscopic surgery for the central bronchogenic carcinoma with invasion of the main bronchus and pulmonary artery: A case report. ( 27900078 )
2016
21
Superior Vena Cava Syndrome due to Thrombosis: A Rare Paraneoplastic Presentation of Bronchogenic Carcinoma. ( 27365560 )
2016
22
Advanced bronchogenic carcinoma presented as cardiac tamponade: a case report and a review of the literature. ( 25581483 )
2015
23
50th Anniversary Landmark Commentary on Jensik RJ, Faber LP, Kittle CF. Segmental resection for bronchogenic carcinoma. Ann Thorac Surg 1979;28:475-83. ( 26354620 )
2015
24
Clinico-pathological Profile of Bronchogenic Carcinoma Among Females in North India. ( 26749914 )
2015
25
Exogenous Lipoid Pneumonia Mimicking Multifocal Bronchogenic Carcinoma. ( 26709482 )
2015
26
50th Anniversary Landmark Commentary on Deslauriers J, Beaulieu M, Benazera A, McClish A. Sleeve pneumonectomy for bronchogenic carcinoma. Ann Thorac Surg 1979;28:465-74. ( 26234828 )
2015
27
A rare case of scapular metastasis from bronchogenic carcinoma with ipsilateral malignant pleural effusion. ( 26180402 )
2015
28
Cookie bite cortical osteolytic lesions: a hint of skeletal metastasis from bronchogenic carcinoma. ( 26001400 )
2015
29
Single-stage bilateral thoracic surgery via a combined VATS and open approach for left central bronchogenic carcinoma with carinal invasion: report of two cases. ( 25990670 )
2015
30
Bronchogenic carcinoma presented as Foville's syndrome. ( 25737321 )
2015
31
Lactoferrin-appended solid lipid nanoparticles of paclitaxel for effective management of bronchogenic carcinoma. ( 24467582 )
2015
32
Pituitary apoplexy in a patient with suspected metastatic bronchogenic carcinoma. ( 24891479 )
2014
33
Rapid on-site evaluation of endobronchial ultrasound-guided fine-needle aspirates: correlation of adequacy assessment and final diagnosis in patients with bronchogenic carcinoma. ( 31051686 )
2014
34
Primary extranodal NK/T-cell lymphoma of the lung: Mimicking bronchogenic carcinoma. ( 26766981 )
2014
35
Occult foreign body in the lung mimicking bronchogenic carcinoma. ( 25519864 )
2014
36
Importance of histological verification of mediastinal lymphadenopathy in exact staging of non-small cell bronchogenic carcinoma. ( 25318920 )
2014
37
Is femoral uptake of Tc99m-methylene diphosphonate on bone scintigraphy in bronchogenic carcinoma an alarming sign: A case report and brief review of literature? ( 25125820 )
2014
38
ACR Appropriateness Criteria non-invasive clinical staging of bronchogenic carcinoma. ( 25086958 )
2014
39
Aspergillus colonization in patients with bronchogenic carcinoma. ( 24771735 )
2014
40
A rare case of sternal erosion due to bronchogenic carcinoma. ( 24591804 )
2014
41
[Resected non-small cell bronchogenic carcinoma stage pIIIA-N2. Which patients will benefit most from adjuvant therapy?]. ( 23453425 )
2014
42
Fibrosing mediastinitis mimicking bronchogenic carcinoma. ( 23372962 )
2013
43
Hypopituitarism as the presenting feature of bronchogenic carcinoma with metastases to the pituitary gland. ( 23776875 )
2013
44
Pulmonary botryomycosis mimicking bronchogenic carcinoma of the lung. ( 25191476 )
2013
45
Metastatic Cardiac Tumor from Bronchogenic Carcinoma via Pulmonary Vein: A Case Report. ( 24392417 )
2013
46
Importance of systemic mediastinal lymphadenectomy in exact staging of bronchogenic carcinoma. ( 24156680 )
2013
47
External auditory canal mass as the first manifestation of a bronchogenic carcinoma: report of a rare case. ( 23837390 )
2013
48
Comparative study analyzing survival and safety of bevacizumab/carboplatin/paclitaxel and cisplatin/pemetrexed in chemotherapy-naïve patients with advanced non-squamous bronchogenic carcinoma not harboring EGFR mutation. ( 23836994 )
2013
49
RPE Adenocarcinoma as the Presenting Sign of Bronchogenic Carcinoma: Diagnostic Dilemma in the Management of a Case. ( 23607017 )
2013
50
Spontaneous hemothorax as a presenting form of bronchogenic carcinoma. ( 23602323 )
2013

Variations for Bronchus Cancer

Cosmic variations for Bronchus Cancer:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10779 TP53 lung,bronchus,carcinoma,NS c.818G>T p.R273L 17:7673802-7673802 0
2 COSM10656 TP53 lung,bronchus,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 0
3 COSM10660 TP53 lung,bronchus,carcinoma,NS c.818G>A p.R273H 17:7673802-7673802 0
4 COSM10718 TP53 lung,bronchus,carcinoma,NS c.524G>T p.R175L 17:7675088-7675088 0
5 COSM10662 TP53 lung,bronchus,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 0
6 COSM6213 EGFR lung,bronchus,carcinoma,NS c.2582T>A p.L861Q 7:55191831-55191831 0

Expression for Bronchus Cancer

Search GEO for disease gene expression data for Bronchus Cancer.

Pathways for Bronchus Cancer

Pathways related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.07 APP SAA1
2 9.74 CYP1A1 JUN

GO Terms for Bronchus Cancer

Cellular components related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.28 APP AVP CD6 CEACAM5 CEACAM7 CRP

Biological processes related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to organic cyclic compound GO:0014070 9.5 AVP CYP1A1 JUN
2 cellular response to copper ion GO:0071280 9.37 APP CYP1A1
3 liver development GO:0001889 9.33 CYP1A1 JUN PTN
4 cellular process GO:0009987 9.26 APP JUN
5 positive regulation of systemic arterial blood pressure GO:0003084 8.96 AVP AVPR2
6 learning GO:0007612 8.8 APP JUN PTN

Molecular functions related to Bronchus Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.26 APP CYP1A1 JUN PGR
2 identical protein binding GO:0042802 9.1 APP CD6 CEACAM5 CRP JUN PGR

Sources for Bronchus Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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