MCID: BRW004
MIFTS: 33

Brown-Sequard Syndrome

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Brown-Sequard Syndrome

MalaCards integrated aliases for Brown-Sequard Syndrome:

Name: Brown-Sequard Syndrome 12 53 54 44 15 73
Hemispinal Cord Syndrome 53
Hemiparaplegic Syndrome 53
Brown-S�quard Syndrome 76
Brown-Squard Syndrome 12
Hemicord Syndrome 53

Classifications:



External Ids:

Disease Ontology 12 DOID:606
ICD10 33 G83.81
MeSH 44 D018437
NCIt 50 C84601
SNOMED-CT 68 27982003
UMLS 73 C0242644

Summaries for Brown-Sequard Syndrome

NIH Rare Diseases : 53 Brown-Sequard syndrome is a rare neurological condition that results from an injury or damage to one side of the spinal cord. This condition results in weakness or paralysis on one side of the body (hemiparaplegia) and a loss of sensation on the opposite side (hemianesthesia). Brown-Sequard syndrome most commonly occurs in the the thoracic spine (upper and middle back). There are several causes of Brown-Sequard syndrome, including: a spinal cord tumor, trauma (such as a puncture wound to the neck or back), infectious or inflammatory diseases (tuberculosis or multiple sclerosis), and disk herniation. Treatment for this condition varies depending on the underlying cause.

MalaCards based summary : Brown-Sequard Syndrome, also known as hemispinal cord syndrome, is related to spinal cord injury and horner's syndrome. An important gene associated with Brown-Sequard Syndrome is AKR1D1 (Aldo-Keto Reductase Family 1 Member D1). Affiliated tissues include spinal cord, lung and breast, and related phenotype is vision/eye.

NINDS : 54 Brown-Sequard syndrome (BSS) is a rare neurological condition characterized by a lesion in the spinal cord which results in weakness or paralysis (hemiparaplegia) on one side of the body and a loss of sensation (hemianesthesia) on the opposite side. BSS may be caused by a spinal cord tumor, trauma (such as a puncture wound to the neck or back), ischemia (obstruction of a blood vessel), or infectious or inflammatory diseases such as tuberculosis, or multiple sclerosis.

Wikipedia : 76 Brown-Séquard syndrome (also known as Brown-Séquard''s hemiplegia, Brown-Séquard''s paralysis,... more...

Related Diseases for Brown-Sequard Syndrome

Diseases related to Brown-Sequard Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 spinal cord injury 10.4
2 horner's syndrome 10.4
3 idiopathic spinal cord herniation 10.4
4 osteochondroma 10.4
5 arteriovenous fistula 10.3
6 hemangioma 10.3
7 myelitis 10.3
8 posterolateral myocardial infarction 10.1 KANTR PLG
9 acute anterolateral myocardial infarction 10.1 KANTR PLG
10 facial neuralgia 10.1 KANTR PLG
11 systemic lupus erythematosus 10.1
12 pheochromocytoma 10.1
13 rheumatoid arthritis 10.1
14 lung cancer susceptibility 3 10.1
15 bone mineral density quantitative trait locus 15 10.1
16 arthritis 10.1
17 spinal disease 10.1
18 thrombosis 10.1
19 klippel-feil syndrome 10.1
20 epidural abscess 10.1
21 arachnoiditis 10.1
22 exostosis 10.1
23 hereditary multiple exostoses 10.1
24 adenocarcinoma 10.1
25 cocaine abuse 10.1
26 influenza 10.1
27 lupus erythematosus 10.1
28 aortic coarctation 10.1
29 transverse myelitis 10.1
30 encephalopathy 10.1
31 neurenteric cyst 10.1
32 atlantoaxial subluxation 10.1
33 cerebral falx meningioma 10.1 KANTR PLG
34 cerebral arteritis 10.1 KANTR PLG
35 ligneous conjunctivitis 10.1 PLG TTR
36 leech infestation 10.1 KANTR PLG
37 apical myocardial infarction 10.1 KANTR PLG
38 spinal cord astrocytoma 10.1 ADAMTS1 GFAP
39 alveolar periostitis 10.1 KANTR PLG
40 tabes dorsalis 10.1 KANTR TCHH
41 anteroseptal myocardial infarction 10.1 KANTR PLG
42 anterior cranial fossa meningioma 10.1 KANTR PLG
43 chronic inflammatory demyelinating polyneuropathy 10.1 AIF1 TTR
44 demyelinating polyneuropathy 10.1 AIF1 TTR
45 petroclival meningioma 10.1 AIF1 KANTR
46 vitreous disease 10.1 GFAP PLG
47 lateral medullary syndrome 10.1 KANTR PLG
48 trigeminal nerve neoplasm 10.0 GFAP KANTR
49 neurilemmoma of the fifth cranial nerve 10.0 GFAP KANTR
50 carotid artery dissection 10.0 KANTR PLG ZNF451

Graphical network of the top 20 diseases related to Brown-Sequard Syndrome:



Diseases related to Brown-Sequard Syndrome

Symptoms & Phenotypes for Brown-Sequard Syndrome

MGI Mouse Phenotypes related to Brown-Sequard Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 AIF1 AKR1D1 BBS2 GFAP PLG TTR

Drugs & Therapeutics for Brown-Sequard Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
2 Walking Adaptability Post-Spinal Cord Injury Completed NCT01851629 Not Applicable

Search NIH Clinical Center for Brown-Sequard Syndrome

Cochrane evidence based reviews: brown-sequard syndrome

Genetic Tests for Brown-Sequard Syndrome

Anatomical Context for Brown-Sequard Syndrome

MalaCards organs/tissues related to Brown-Sequard Syndrome:

41
Spinal Cord, Lung, Breast, Bone, Thyroid

Publications for Brown-Sequard Syndrome

Articles related to Brown-Sequard Syndrome:

(show top 50) (show all 100)
# Title Authors Year
1
Teaching NeuroImages: Sulcal artery syndrome: A hemicord infarct presenting with incomplete Brown-Sequard syndrome. ( 29581335 )
2018
2
Brown-Sequard syndrome. ( 29766141 )
2018
3
Cervical disc herniation causing Brown-Sequard syndrome: Case report and review of literature (CARE-compliant). ( 30213001 )
2018
4
A rare case of Brown-Sequard syndrome caused by traumatic cervical epidural hematoma. ( 30488011 )
2018
5
Spinal cord injury without radiological abnormality (SCIWORA) manifested as self-limited brown-SEQUARD syndrome. ( 30533479 )
2018
6
Controversies in the differential diagnosis of Brown-Sequard syndrome due to cervical spinal disease from stroke: A case series. ( 28971161 )
2017
7
Transpedicular excision of a thoracic intraspinal osteochondroma in a patient with Hereditary Multiple Exostoses and Brown-Sequard syndrome: a case report. ( 29258931 )
2017
8
Lateral medullary infarction with similar features of Brown Sequard syndrome caused by vertebrobasilar dysplasia and Klippel-Feil syndrome: A case report. ( 29137102 )
2017
9
Brown-Sequard syndrome caused by hyperextension in a patient with atlantoaxial subluxation due to an os odontoideum. ( 29174476 )
2017
10
Poster 443 Diving Injury Resulting in a Jefferson Fracture, Vertebral Artery Thrombosis and Brown Sequard Syndrome: A Case Report. ( 27673193 )
2016
11
Brown-Sequard syndrome associated with Horner syndrome following cervical disc herniation. ( 28053775 )
2016
12
Penetrating spinal cord injury with screwdriver in situ, leading to Brown-Sequard syndrome. ( 27114679 )
2016
13
Acquired Spinal Arteriovenous Fistula Presenting as Brown Sequard Syndrome and Endovascular Treatment Outcome. ( 27593715 )
2016
14
Brown-Sequard syndrome produced by calcified herniated cervical disc and posterior vertebral osteophyte: Case report. ( 27047233 )
2015
15
Idiopathic Spinal Cord Herniation Presented as Brown-Sequard Syndrome : A Case Report and Surgical Outcome. ( 26539277 )
2015
16
Brown-Sequard Syndrome after an Accidental Stab Injury of Cervical Spine: A Case Report. ( 27169090 )
2015
17
An unusual case of Brown-Sequard syndrome. ( 24983085 )
2014
18
A ruptured pheochromocytoma: an unlikely cause of Brown-Sequard syndrome. ( 24582183 )
2014
19
Brown-Sequard syndrome associated with unusual spinal cord injury by a screwdriver stab wound. ( 24482724 )
2014
20
Management of Brown-Sequard syndrome in cervical disc diseases. ( 24101266 )
2013
21
Cervical epidural haematoma causing Brown- Sequard syndrome: a case report. ( 24366803 )
2013
22
Spontaneous cervical epidural hematoma presenting as brown-sequard syndrome following repetitive korean traditional deep bows. ( 23526134 )
2013
23
MRI features of spinal cord decompression sickness presenting as a Brown-Sequard syndrome. ( 22828817 )
2012
24
Cervical disc herniation producing acute Brown-Sequard syndrome: dynamic changes documented by intraoperative neuromonitoring. ( 21674209 )
2012
25
Brown-sequard syndrome after endovascular embolization of vertebral hemangioma. ( 22310318 )
2012
26
Cervical disc herniation manifesting as a Brown-Sequard syndrome. ( 22865973 )
2012
27
Subclinical cervical osteochondroma presenting as brown-sequard syndrome after trivial neck trauma. ( 22737306 )
2012
28
Pediatric odontoid fracture causing Brown-Sequard syndrome: a case report. ( 22822585 )
2012
29
Intramedullary spinal neurocysticercosis presenting as brown-sequard syndrome. ( 23316264 )
2012
30
Central Brown-Sequard syndrome caused by hyperextension: an unexpected complication of cervical pedicle screw fixation. ( 22305154 )
2012
31
Diffusion tensor imaging and tractography in Brown-Sequard syndrome. ( 23045298 )
2012
32
Spontaneous cervical epidural hematoma causing brown-sequard syndrome. ( 25983837 )
2012
33
Brown Sequard Syndrome Secondary to a Spontaneous Cervical Epidural Hematoma - A Rare Entity. ( 27298881 )
2012
34
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( 21752788 )
2011
35
Pneumocephalus and Brown-Sequard syndrome caused by a stab wound to the back. ( 21489171 )
2011
36
Successful peripheral nerve field stimulation for thoracic radiculitis following Brown-Sequard syndrome. ( 21992248 )
2011
37
Brown-Sequard syndrome revealing intradural thoracic disc herniation. ( 20589517 )
2011
38
Outcome after incomplete spinal cord injury: central cord versus Brown-Sequard syndrome. ( 19901956 )
2010
39
Paraspinal muscle impingement causing acute Brown-Sequard syndrome after posterior cervical decompression. ( 20228701 )
2010
40
Re: Brown-Sequard syndrome produced by traumatic cervical disc herniation. ( 20795990 )
2010
41
Diffusion tensor tractography demonstration of partially injured spinal cord tracts in a patient with posttraumatic Brown Sequard syndrome. ( 20882629 )
2010
42
Cervical epidural abscess presenting with Brown-Sequard syndrome in a patient with type 2 diabetes. ( 20647654 )
2010
43
Brown-Sequard syndrome after thoracic endovascular aortic repair. ( 19833642 )
2010
44
Brown-Sèquard syndrome caused by type III odontoid fracture: a case report and review of the literature. ( 20042945 )
2010
45
Delayed onset of Brown-Sequard syndrome involving upper extremity pain. ( 19210635 )
2009
46
Spontaneous cervical epidural hematoma causing Brown-Sequard syndrome: case report. ( 19263364 )
2009
47
Cervical osteochondroma presenting as brown-sequard syndrome in a child with hereditary multiple exostosis. ( 19516952 )
2009
48
Idiopathic transverse myelitis presenting as the Brown-Sequard syndrome. ( 18332885 )
2009
49
Spinal decompression sickness presenting as partial Brown-Sequard syndrome and treated with robotic-assisted body-weight support treadmill training. ( 19197576 )
2009
50
Brown-Sequard syndrome associated with Horner's syndrome following a penetrating drill bit injury to the cervical spine. ( 19386500 )
2009

Variations for Brown-Sequard Syndrome

Expression for Brown-Sequard Syndrome

Search GEO for disease gene expression data for Brown-Sequard Syndrome.

Pathways for Brown-Sequard Syndrome

GO Terms for Brown-Sequard Syndrome

Biological processes related to Brown-Sequard Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 8.96 ADAMTS1 AIF1
2 intermediate filament organization GO:0045109 8.62 GFAP TCHH

Sources for Brown-Sequard Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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