MCID: BRW004
MIFTS: 36

Brown-Sequard Syndrome

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Brown-Sequard Syndrome

MalaCards integrated aliases for Brown-Sequard Syndrome:

Name: Brown-Sequard Syndrome 12 54 55 45 15 17 74
Hemispinal Cord Syndrome 54
Hemiparaplegic Syndrome 54
Brown-Séquard Syndrome 77
Brown-Squard Syndrome 12
Hemicord Syndrome 54

Classifications:



External Ids:

Disease Ontology 12 DOID:606
MeSH 45 D018437
NCIt 51 C84601
SNOMED-CT 69 27982003
ICD10 34 G83.81
UMLS 74 C0242644

Summaries for Brown-Sequard Syndrome

NIH Rare Diseases : 54 Brown-Sequard syndrome is a rare neurological condition that results from an injury or damage to one side of the spinal cord. This condition results in weakness or paralysis on one side of the body (hemiparaplegia) and a loss of sensation on the opposite side (hemianesthesia). Brown-Sequard syndrome most commonly occurs in the the thoracic spine (upper and middle back). There are several causes of Brown-Sequard syndrome, including: a spinal cord tumor, trauma (such as a puncture wound to the neck or back), infectious or inflammatory diseases (tuberculosis or multiple sclerosis), and disk herniation. Treatment for this condition varies depending on the underlying cause.

MalaCards based summary : Brown-Sequard Syndrome, also known as hemispinal cord syndrome, is related to spinal cord injury and horner's syndrome. An important gene associated with Brown-Sequard Syndrome is ALDH5A1 (Aldehyde Dehydrogenase 5 Family Member A1). Affiliated tissues include spinal cord, lung and colon, and related phenotype is renal/urinary system.

NINDS : 55 Brown-Sequard syndrome (BSS) is a rare neurological condition characterized by a lesion in the spinal cord which results in weakness or paralysis (hemiparaplegia) on one side of the body and a loss of sensation (hemianesthesia) on the opposite side. BSS may be caused by a spinal cord tumor, trauma (such as a puncture wound to the neck or back), ischemia (obstruction of a blood vessel), or infectious or inflammatory diseases such as tuberculosis, or multiple sclerosis.

Wikipedia : 77 Brown-Séquard syndrome (also known as Brown-Séquard''s hemiplegia, Brown-Séquard''s paralysis,... more...

Related Diseases for Brown-Sequard Syndrome

Diseases related to Brown-Sequard Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 spinal cord injury 10.4
2 horner's syndrome 10.4
3 idiopathic spinal cord herniation 10.4
4 multiple sclerosis 10.4
5 hemangioma 10.3
6 exostosis 10.3
7 myelitis 10.3
8 osteochondroma 10.3
9 spondylosis, cervical 10.3
10 spondylosis 10.3
11 herpes zoster 10.3
12 spinal cord infarction 10.3
13 posterolateral myocardial infarction 10.2 KANTR PLG
14 acute anterolateral myocardial infarction 10.2 KANTR PLG
15 facial neuralgia 10.2 KANTR PLG
16 cerebral falx meningioma 10.2 KANTR PLG
17 cerebral arteritis 10.2 KANTR PLG
18 ligneous conjunctivitis 10.2 PLG TTR
19 leech infestation 10.2 KANTR PLG
20 apical myocardial infarction 10.2 KANTR PLG
21 tabes dorsalis 10.2 KANTR TCHH
22 spinal cord astrocytoma 10.2 ADAMTS1 GFAP
23 alveolar periostitis 10.2 KANTR PLG
24 anteroseptal myocardial infarction 10.2 KANTR PLG
25 chronic inflammatory demyelinating polyneuropathy 10.2 AIF1 TTR
26 anterior cranial fossa meningioma 10.2 KANTR PLG
27 demyelinating polyneuropathy 10.2 AIF1 TTR
28 petroclival meningioma 10.1 AIF1 KANTR
29 systemic lupus erythematosus 10.1
30 pheochromocytoma 10.1
31 rheumatoid arthritis 10.1
32 lung cancer susceptibility 3 10.1
33 bone mineral density quantitative trait locus 15 10.1
34 arteriovenous fistula 10.1
35 arthritis 10.1
36 leukemia 10.1
37 adrenal gland pheochromocytoma 10.1
38 spinal disease 10.1
39 thrombosis 10.1
40 cysticercosis 10.1
41 klippel-feil syndrome 10.1
42 epidural abscess 10.1
43 arachnoiditis 10.1
44 adenocarcinoma 10.1
45 cocaine abuse 10.1
46 influenza 10.1
47 lupus erythematosus 10.1
48 aortic coarctation 10.1
49 transverse myelitis 10.1
50 encephalopathy 10.1

Graphical network of the top 20 diseases related to Brown-Sequard Syndrome:



Diseases related to Brown-Sequard Syndrome

Symptoms & Phenotypes for Brown-Sequard Syndrome

MGI Mouse Phenotypes related to Brown-Sequard Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 ADAMTS1 ALDH5A1 BBS2 PLG TTR

Drugs & Therapeutics for Brown-Sequard Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Retraining Walking After Spinal Cord Injury Unknown status NCT00059553 Phase 2, Phase 3
2 Walking Adaptability Post-Spinal Cord Injury Completed NCT01851629 Not Applicable

Search NIH Clinical Center for Brown-Sequard Syndrome

Cochrane evidence based reviews: brown-sequard syndrome

Genetic Tests for Brown-Sequard Syndrome

Anatomical Context for Brown-Sequard Syndrome

MalaCards organs/tissues related to Brown-Sequard Syndrome:

42
Spinal Cord, Lung, Colon, Breast, Bone, Thyroid, Adrenal Gland

Publications for Brown-Sequard Syndrome

Articles related to Brown-Sequard Syndrome:

(show top 50) (show all 198)
# Title Authors Year
1
Spinal Cord Syphilitic Gumma Presenting with Brown-Séquard Syndrome: A Case Report and Literature Review. ( 31028074 )
2019
2
Brown-Sequard syndrome caused by hyperextension in a patient with atlantoaxial subluxation due to an os odontoideum. ( 29174476 )
2018
3
Brown-Séquard syndrome and cervical post-traumatic subarachnoid hematoma. ( 29066098 )
2018
4
Transpedicular Excision of a Thoracic Intraspinal Osteochondroma in a Patient with Hereditary Multiple Exostoses and Brown-Séquard Syndrome. ( 29258931 )
2018
5
Brown-Séquard Syndrome Caused by Blunt Cervical Trauma with Radiographic Correlation. ( 29492143 )
2018
6
Teaching NeuroImages: Sulcal artery syndrome: A hemicord infarct presenting with incomplete Brown-Sequard syndrome. ( 29581335 )
2018
7
Brown-Sequard syndrome. ( 29766141 )
2018
8
Cervical disc herniation causing Brown-Sequard syndrome: Case report and review of literature (CARE-compliant). ( 30213001 )
2018
9
A rare case of Brown-Sequard syndrome caused by traumatic cervical epidural hematoma. ( 30488011 )
2018
10
Spinal cord injury without radiological abnormality (SCIWORA) manifested as self-limited brown-SEQUARD syndrome. ( 30533479 )
2018
11
Extramedullary Cavernous Hemangioma with Intradural and Extradural Growth and Clinical Symptoms of Brown-Séquard Syndrome: Case Report and Review of the Literature. ( 27867117 )
2017
12
Teaching NeuroImages: Intraspinal synovial cyst causing Brown-Séquard syndrome: Uncommon cause of a classic syndrome. ( 28533354 )
2017
13
Brown-Séquard Syndrome as a First Presentation of Multiple Sclerosis. ( 28951696 )
2017
14
Controversies in the differential diagnosis of Brown-Sequard syndrome due to cervical spinal disease from stroke: A case series. ( 28971161 )
2017
15
Lateral medullary infarction with similar features of Brown Sequard syndrome caused by vertebrobasilar dysplasia and Klippel-Feil syndrome: A case report. ( 29137102 )
2017
16
Acquired Spinal Arteriovenous Fistula Presenting as Brown-Séquard Syndrome and Endovascular Treatment Outcome. ( 27593715 )
2016
17
Brown-Séquard syndrome without vascular injury associated with Horner's syndrome after a stab injury to the neck. ( 25659820 )
2016
18
Progressive Brown-Séquard syndrome: A rare manifestation of cervical disc herniation. ( 26921137 )
2016
19
Penetrating spinal cord injury with screwdriver in situ, leading to Brown-Sequard syndrome. ( 27114679 )
2016
20
Re: Case report-Brown-Séquard syndrome: a rare manifestation of decompression sickness. ( 27162257 )
2016
21
Mystery Case: Brown-Séquard syndrome caused by idiopathic spinal cord herniation. ( 27462042 )
2016
22
Poster 443 Diving Injury Resulting in a Jefferson Fracture, Vertebral Artery Thrombosis and Brown Sequard Syndrome: A Case Report. ( 27673193 )
2016
23
Teaching NeuroImages: One-and-a-half Brown-Séquard syndrome: When spinal neuroanatomy helps localize the lesion. ( 27765829 )
2016
24
Brown-Sequard syndrome associated with Horner syndrome following cervical disc herniation. ( 28053775 )
2016
25
Intramedullary spinal cord neurocysticercosis presenting as Brown-Séquard syndrome. ( 25595849 )
2015
26
Partial Brown-Séquard syndrome due to presumed fibrocartilaginous embolism. ( 25715750 )
2015
27
Brown-Séquard syndrome: a rare manifestation of decompression sickness. ( 26400970 )
2015
28
Spontaneous Spinal Subdural Hematoma causing Brown-Séquard Syndrome with Thrombocytopenic Myelodysplastic Syndrome. ( 26512288 )
2015
29
Idiopathic Spinal Cord Herniation Presented as Brown-Sequard Syndrome : A Case Report and Surgical Outcome. ( 26539277 )
2015
30
Brown-Sequard syndrome produced by calcified herniated cervical disc and posterior vertebral osteophyte: Case report. ( 27047233 )
2015
31
Brown-Sequard Syndrome after an Accidental Stab Injury of Cervical Spine: A Case Report. ( 27169090 )
2015
32
Brown-Sequard syndrome associated with unusual spinal cord injury by a screwdriver stab wound. ( 24482724 )
2014
33
Disseminated Mycobacterium avium complex infection manifested as Brown-Séquard syndrome in an HIV-infected patient. ( 24534249 )
2014
34
A ruptured pheochromocytoma: an unlikely cause of Brown-Sequard syndrome. ( 24582183 )
2014
35
Two cases of Brown-Séquard syndrome in penetrating spinal cord injuries. ( 24825034 )
2014
36
An unusual case of Brown-Sequard syndrome. ( 24983085 )
2014
37
Brown-séquard syndrome caused by a cervical synovial cyst. ( 25024827 )
2014
38
Teaching NeuroImages: partial brown-Séquard syndrome: a rare presentation of CMV myelitis. ( 25092932 )
2014
39
Brown-Séquard syndrome from herniation of a thoracic disc. ( 25157052 )
2014
40
Solitary thoracic osteochondroma presenting as Brown-Séquard syndrome. ( 25404250 )
2014
41
Brown-Séquard syndrome. ( 25488458 )
2014
42
Brown-Séquard syndrome in a 11-year-old girl due to penetrating glass injury to the thoracic spine. ( 23412183 )
2013
43
Spontaneous cervical epidural hematoma presenting as brown-sequard syndrome following repetitive korean traditional deep bows. ( 23526134 )
2013
44
Radiographic and intraoperative imaging of a hemisection of the spinal cord resulting in a pure Brown-Séquard syndrome: case report and review of the literature. ( 23584224 )
2013
45
Comparative biomechanical analysis of gait in patients with central cord and Brown-Séquard syndrome. ( 23600711 )
2013
46
Brown-Séquard syndrome after a gun shot wound to the cervical spine: a case report. ( 24051332 )
2013
47
Management of Brown-Sequard syndrome in cervical disc diseases. ( 24101266 )
2013
48
Cervical epidural haematoma causing Brown-Sequard syndrome: a case report. ( 24366803 )
2013
49
Vertebral artery dissect injury with brown-séquard syndrome by a neural foramen penetrated electric screw driver bit : a case report. ( 24891861 )
2013
50
Spontaneous spinal epidural hematoma presenting as Brown-Séquard syndrome. ( 23380090 )
2013

Variations for Brown-Sequard Syndrome

Expression for Brown-Sequard Syndrome

Search GEO for disease gene expression data for Brown-Sequard Syndrome.

Pathways for Brown-Sequard Syndrome

GO Terms for Brown-Sequard Syndrome

Biological processes related to Brown-Sequard Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 8.96 ADAMTS1 AIF1
2 intermediate filament organization GO:0045109 8.62 GFAP TCHH

Sources for Brown-Sequard Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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