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BRWNS
MCID: BRW006
MIFTS: 27

Brown Syndrome (BRWNS)

Categories: Eye diseases, Muscle diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes
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Aliases & Classifications for Brown Syndrome

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MalaCards integrated aliases for Brown Syndrome:

Name: Brown Syndrome 57 73 20
Tendon Sheath Adherence, Superior Oblique 20
Superior Oblique Tendon Sheath Syndrome 20
Brown Tendon Sheath Syndrome 70
Brwns 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
noted in early childhood in most patients
some patients have onset in second decade of life


HPO:

31
brown syndrome:
Inheritance autosomal dominant inheritance


Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases Muscle diseases
See all MalaCards categories (disease lists)


External Ids:

OMIM® 57 616407
MedGen 41 C0155339
SNOMED-CT via HPO 68 24982008 263681008
UMLS 70 C0155339
Sources

Summaries for Brown Syndrome

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OMIM® : 57 Brown syndrome, originally described by Brown (1950), is characterized by the inability to elevate the adducted eye actively or passively. There is less elevation deficit with the eye in midposition, and minimal or no deficit in abduction. There can also be divergence on upgaze, downshoot, or widening of the palpebral fissure on adduction, primary hypotropia, and anomalous head posture. Brown syndrome accounts for approximately 2% of strabismus cases. Ten percent of cases are bilateral, and left- and right-sided unilateral cases are equal in frequency. There is no gender predilection (summary by Heidary et al., 2012). (616407) (Updated 20-May-2021)

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to mental retardation, x-linked, syndromic, turner type and spastic paraplegia facial cutaneous lesions, and has symptoms including spasm of conjugate gaze, pseudoophthalmoplegia and smooth pursuit deficiency. An important gene associated with Brown Syndrome is MRXSBWB (Brooks-Wisniewski-Brown Syndrome). Affiliated tissues include eye, lung and myeloid, and related phenotypes are diplopia and brown anomaly

GARD : 20 Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth ( congenital ) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.

Wikipedia : 73 Brown's syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

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Related Diseases for Brown Syndrome

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Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 mental retardation, x-linked, syndromic, turner type 11.3
2 spastic paraplegia facial cutaneous lesions 11.2
3 syndromic x-linked intellectual disability turner type 11.0
4 cramp-fasciculation syndrome 11.0
5 strabismus 10.3
6 mechanical strabismus 10.3
7 hypotropia 10.3
8 suppression amblyopia 10.1
9 amblyopia 10.1
10 hypertropia 10.1
11 duane retraction syndrome 1 10.0
12 ptosis 10.0
13 monocular esotropia 9.9
14 alternating exotropia 9.9
15 exotropia 9.9
16 tenosynovitis 9.9
17 esotropia 9.9
18 astigmatism 9.8
19 tukel syndrome 9.8
20 congenital ptosis 9.8
21 cysticercosis 9.8
22 spastic diplegia 9.8
23 duane retraction syndrome 9.8
24 refractive error 9.8
25 isolated duane retraction syndrome 9.8
26 congenital trochlear nerve palsy 9.8
27 marcus gunn phenomenon 9.7
28 moebius syndrome 9.7
29 temporal arteritis 9.7
30 torticollis 9.7
31 velocardiofacial syndrome 9.7
32 3-methylglutaconic aciduria, type iii 9.7
33 kearns-sayre syndrome 9.7
34 leukemia, acute myeloid 9.7
35 fibrosis of extraocular muscles, congenital, 2 9.7
36 duane retraction syndrome 2 9.7
37 cardiac conduction disease with or without dilated cardiomyopathy 9.7
38 weill-marchesani syndrome 9.7
39 brachydactyly 9.7
40 distal arthrogryposis 9.7
41 alcohol-related neurodevelopmental disorder 9.7
42 scoliosis 9.7
43 lung abscess 9.7
44 geleophysic dysplasia 9.7
45 brown's tendon sheath syndrome 9.7
46 fourth cranial nerve palsy 9.7
47 microcephaly 9.7
48 hydrocephalus 9.7
49 myopia 9.7
50 anisometropia 9.7

Graphical network of the top 20 diseases related to Brown Syndrome:



Diseases related to Brown Syndrome
Sources

Symptoms & Phenotypes for Brown Syndrome

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Human phenotypes related to Brown Syndrome:

31
# Description HPO Frequency HPO Source Accession
1 diplopia 31 HP:0000651
2 brown anomaly 31 HP:0031622

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Head And Neck Head:
chin-up head posture

Head And Neck Eyes:
limited or absent ability to elevate eye while in adducted (nasal) position

Clinical features from OMIM®:

616407 (Updated 20-May-2021)

UMLS symptoms related to Brown Syndrome:


spasm of conjugate gaze; pseudoophthalmoplegia; smooth pursuit deficiency
Sources

Drugs & Therapeutics for Brown Syndrome

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Search Clinical Trials , NIH Clinical Center for Brown Syndrome

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Genetic Tests for Brown Syndrome

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Sources

Anatomical Context for Brown Syndrome

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MalaCards organs/tissues related to Brown Syndrome:

40
Eye, Lung, Myeloid, Bone, Breast
Sources

Publications for Brown Syndrome

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Articles related to Brown Syndrome:

(show top 50) (show all 173)
# Title Authors PMID Year
1
Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders. 57 61
20535495 2010
2
Familial unilateral Brown syndrome. 57 61
18711279 2008
3
Bilateral Brown syndrome in monozygotic twins. 61 57
18258471 2008
4
Familial unilateral Brown syndrome. 57 61
12324876 2002
5
The heritability of strabismus. 61 57
7953247 1994
6
Bilateral Brown syndrome in three siblings. 61 57
1757853 1991
7
Brown syndrome: clinical features and results of superior oblique tenotomy. 61
33567010 2021
8
Superior oblique tendon thinning for Brown syndrome. 61
33621687 2021
9
Post-traumatic superior oblique tendon nodule associated with acquired Brown syndrome. 61
32687877 2020
10
THE SPECTRUM OF UNDERLYING DISEASES IN CHILDREN WITH TORTICOLLIS. 61
33759163 2020
11
Brown Syndrome from Local Anesthesia for Inferior Orbital Fat Decompression. 61
32687487 2020
12
A case of acquired Brown syndrome treated with adalimumab. 61
32087325 2020
13
[Brown's atavistic superior oblique syndrome: etiology of different types of motility disorders in congenital Brown's syndrome]. 61
31720845 2020
14
Acquired Brown Syndrome in Head Trauma: Does Fixation of Associated Nasal and Frontal Bone Fractures Provide a Cure? 61
32999986 2020
15
Treatment of acquired Brown syndrome in a child with a single intramuscular systemic depot steroid injection. 61
31145990 2019
16
Acquired reversible Brown syndrome caused by focal abscess of the superior oblique muscle. 61
30710645 2019
17
Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. 61
30415012 2019
18
Acquired Pediatric Brown Syndrome Secondary to Sinusitis. 61
30907972 2019
19
Intratrochlear steroid injections in acquired Brown syndrome-a case series. 61
30611003 2019
20
Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. 61
30236966 2018
21
A Case Report of Progressive Brown Syndrome? 61
32999962 2018
22
Facial Fractures: Pearls and Perspectives. 61
29697631 2018
23
Magnetic Resonance Findings at 3 Tesla in Brown Syndrome. 61
29543977 2018
24
Horizontal Deviations in Congenital Brown Syndrome. 61
29257185 2018
25
Brown Syndrome Following Upper Eyelid Ptosis Repair. 61
29467810 2018
26
MRI of acquired Brown syndrome: a report of two cases. 61
29487642 2018
27
Surgical Management of Brown Syndrome. 61
29156074 2017
28
Steroid intra-trochlear injection for the treatment of acquired Brown syndrome secondary to trochleitis. 61
28770346 2017
29
Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report. 61
28841851 2017
30
Ocular Causes of Abnormal Head Position: Strabismus Clinic Data. 61
28845325 2017
31
Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome. 61
28625469 2017
32
The frequency and causes of abnormal head position based on an ophthalmology clinic's findings: is it overlooked? 61
28009406 2017
33
Sequential congenital and acquired presentation of bilateral Brown syndrome. 61
28577917 2017
34
Resolution of acquired Brown syndrome with oral steroid therapy. 61
28757707 2017
35
[Sensory and motor clinical presentation of congenital retraction syndromes: Stilling-Duane and Brown syndrome]. 61
28476458 2017
36
[Bilateral acquired Brown syndrome]. 61
28272729 2017
37
[When and how to perform the superior oblique tucking surgery]. 61
27562275 2016
38
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. 61
26854770 2016
39
Establishing a surgical outreach program in the developing world: pediatric strabismus surgery in Guatemala City, Guatemala. 61
26691031 2015
40
Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. 61
26529043 2015
41
Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. 61
26397461 2015
42
Quantitative Intraoperative Torsional Forced Duction Test. 61
26130329 2015
43
Magnetic resonance imaging in congenital Brown syndrome. 61
25744329 2015
44
Treatment and diagnosis of congenital fourth nerve palsies: an update. 61
26247132 2015
45
Considerations on the etiology of congenital Brown syndrome. 61
26163776 2015
46
Surgical Excision of Orbital Cysticercosis Lodged in Superior Oblique Muscle: Clinical Case Report. 61
26222841 2015
47
[Brown syndrome: clinical and radiological correlation]. 61
26310116 2015
48
Three cases of acquired simulated brown syndrome after blowout fracture operations. 61
26015892 2015
49
Results of anterior tucking of the superior oblique muscle tendon in bilateral fourth nerve palsy. 61
25902096 2015
50
Brown syndrome with severe amblyopia: a case report from Africa. 61
26090014 2015
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Variations for Brown Syndrome

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Expression for Brown Syndrome

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Search GEO for disease gene expression data for Brown Syndrome.
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Pathways for Brown Syndrome

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GO Terms for Brown Syndrome

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Sources for Brown Syndrome

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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