Brown Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

BRWNS MCID: BRW006 MIFTS: 27	Brown Syndrome (BRWNS) Categories: Muscle diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Brown Syndrome

MalaCards integrated aliases for Brown Syndrome:

Name: Brown Syndrome ⁵⁷ ⁷⁶ ⁵³

Tendon Sheath Adherence, Superior Oblique ⁵³

Superior Oblique Tendon Sheath Syndrome ⁵³

Brown Tendon Sheath Syndrome ⁷³

Brwns ⁵⁷

Characteristics:

OMIM:

⁵⁷

Inheritance:
autosomal dominant

Miscellaneous:
noted in early childhood in most patients
some patients have onset in second decade of life

HPO:

³²

brown syndrome:
Inheritance autosomal dominant inheritance

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁷ 616407

MedGen ⁴² C0155339

SNOMED-CT via HPO ⁶⁹ 263681008

UMLS ⁷³ C0155339

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Summaries for Brown Syndrome

OMIM : ⁵⁷ Brown syndrome, originally described by Brown (1950), is characterized by the inability to elevate the adducted eye actively or passively. There is less elevation deficit with the eye in midposition, and minimal or no deficit in abduction. There can also be divergence on upgaze, downshoot, or widening of the palpebral fissure on adduction, primary hypotropia, and anomalous head posture. Brown syndrome accounts for approximately 2% of strabismus cases. Ten percent of cases are bilateral, and left- and right-sided unilateral cases are equal in frequency. There is no gender predilection (summary by Heidary et al., 2012). (616407)

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks-wisniewski-brown syndrome and spastic paraplegia facial cutaneous lesions, and has symptoms including spasm of conjugate gaze, pseudoophthalmoplegia and smooth pursuit deficiency. An important gene associated with Brown Syndrome is PHOX2A (Paired Like Homeobox 2A). Affiliated tissues include eye.

NIH Rare Diseases : ⁵³ Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.

Wikipedia : ⁷⁶ Brown''s syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

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Related Diseases for Brown Syndrome

Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score
1	brooks-wisniewski-brown syndrome	12.2
2	spastic paraplegia facial cutaneous lesions	11.2
3	cramp-fasciculation syndrome	11.0
4	cysticercosis	9.8
5	amblyopia	9.8
6	rheumatoid arthritis	9.6
7	strabismus	9.6
8	velocardiofacial syndrome	9.6
9	geleophysic dysplasia 1	9.6
10	geleophysic dysplasia 2	9.6
11	arthritis	9.6
12	sinusitis	9.6
13	systemic scleroderma	9.6
14	distal arthrogryposis	9.6
15	ptosis	9.6
16	monocular esotropia	9.6
17	fourth cranial nerve palsy	9.6
18	duane retraction syndrome	9.6
19	arthropathy	9.6
20	cranial nerve palsy	9.6
21	juvenile rheumatoid arthritis	9.6
22	herpes zoster	9.6
23	psoriasis	9.6
24	tenosynovitis	9.6
25	accommodative esotropia	9.6
26	esotropia	9.6
27	geleophysic dysplasia	9.6
28	geleophysic dwarfism	9.6
29	herpes zoster ophthalmicus	9.6
30	osteochondroma	9.6
31	trochleitis	9.6
32	isolated duane retraction syndrome	9.6

Graphical network of the top 20 diseases related to Brown Syndrome:

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Symptoms & Phenotypes for Brown Syndrome

Symptoms via clinical synopsis from OMIM:

⁵⁷

Head And Neck Head:
chin-up head posture

Head And Neck Eyes:
limited or absent ability to elevate eye while in adducted (nasal) position

Clinical features from OMIM:

616407

UMLS symptoms related to Brown Syndrome:

spasm of conjugate gaze, pseudoophthalmoplegia, smooth pursuit deficiency

Sources

Drugs & Therapeutics for Brown Syndrome

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies	Recruiting	NCT03059420

Search NIH Clinical Center for Brown Syndrome

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Genetic Tests for Brown Syndrome

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Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

⁴¹

Eye

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Publications for Brown Syndrome

Articles related to Brown Syndrome:

(show top 50) (show all 84)

#	Title	Authors	Year
1	Magnetic Resonance Findings at 3 Tesla in Brown Syndrome. ( 29543977 )	Antonucci M.U....Cheeseman E.W.	2018
2	MRI of acquired Brown syndrome: a report of two cases. ( 29487642 )	Lang M....Badve C.	2018
3	Brown Syndrome Following Upper Eyelid Ptosis Repair. ( 29467810 )	Wang Y....McClelland C.M.	2018
4	Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. ( 30415012 )	Khan AO...Schatz P	2018
5	Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. ( 30236966 )	Sharma M...Dagi LR	2018
6	Horizontal Deviations in Congenital Brown Syndrome. ( 29257185 )	Dotan G....Friling R.	2017
7	Sequential congenital and acquired presentation of bilateral Brown syndrome. ( 28577917 )	Osigian C.J....Capo H.	2017
8	Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report. ( 28841851 )	Yang H.K....Hwang J.M.	2017
9	Steroid intra-trochlear injection for the treatment of acquired Brown syndrome secondary to trochleitis. ( 28770346 )	Giannaccare G....Campos E.C.	2017
10	Surgical Management of Brown Syndrome. ( 29156074 )	Deutsch J.A....Wagner R.S.	2017
11	Resolution of acquired Brown syndrome with oral steroid therapy. ( 28757707 )	Chhablani P.P....Chandrasekharan A.	2017
12	Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome. ( 28625469 )		2017
13	Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. ( 26854770 )		2016
14	Brown syndrome with severe amblyopia: a case report from Africa. ( 26090014 )	Olusanya B.A.	2015
15	Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26397461 )	Suh S.Y....Demer J.L.	2015
16	Magnetic resonance imaging in congenital Brown syndrome. ( 25744329 )	Kim J.H....Hwang J.M.	2015
17	Three cases of acquired simulated brown syndrome after blowout fracture operations. ( 26015892 )	Ji S.Y....Yang W.S.	2015
18	Considerations on the etiology of congenital Brown syndrome. ( 26163776 )	Coussens T....Ellis F.J.	2015
19	Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26529043 )		2015
20	Clinical evolution of bilateral Brown syndrome. ( 25439308 )	Buzzonetti L....Capozzi P.	2014
21	Trochlea surgery for acquired Brown syndrome. ( 24568984 )	Kokubo K....Kamisasanuki T.	2014
22	The results of Brown syndrome surgery with superior oblique split tendon lengthening. ( 24564724 )		2014
23	Clinical progression of untreated bilateral Brown syndrome. ( 24698613 )		2014
24	Ethmoidal sinus mucocele as a cause of acquired brown syndrome. ( 25276088 )		2014
25	Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. ( 23370414 )	Sekeroglu H.T....Arslan U.	2013
26	Simulated Brown syndrome in the contralateral eye in superior oblique palsy. ( 22234524 )	Kim J.H....Hwang J.M.	2013
27	Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )		2013
28	Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. ( 23237754 )	Ellis F.J....Schuller J.	2012
29	Sequential presentation of bilateral Brown syndrome. ( 22525185 )	SekeroA9lu H.T....Sener E.C.	2012
30	Absence of the fourth cranial nerve in congenital Brown syndrome. ( 22268674 )		2012
31	Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. ( 22632930 )		2012
32	Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. ( 21665503 )		2011
33	Congenital unilateral brown syndrome in non-twin siblings. ( 21766745 )		2011
34	Acquired Brown syndrome: report of two cases. ( 21907127 )		2011
35	Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. ( 21216206 )		2011
36	Late spontaneous resolution of congenital Brown syndrome. ( 21168089 )	Abrams M.S.	2010
37	We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. ( 20451849 )	Suh D.W.	2010
38	Late spontaneous resolution of congenital Brown syndrome. ( 20637665 )	Lambert S.R.	2010
39	Brown syndrome in one pair of dizygotic twins: a case report. ( 20076806 )	Attarzadeh A....Rahat F.	2010
40	A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. ( 20157416 )		2010
41	Brown syndrome with bifid scleral insertion of the superior oblique. ( 19496499 )	Park S.W....Park Y.G.	2009
42	MR imaging features of acquired Brown syndrome. ( 19369611 )	Currie S....Goddard T.	2009
43	Spontaneous resolution in patients with congenital Brown syndrome. ( 19084441 )		2009
44	Brown syndrome--operate or observe? ( 19393508 )	Archer SM	2009
45	Management of Brown syndrome. ( 19085429 )	Lee J.	2008
46	Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. ( 18538400 )	Suh D.W....Hunter D.G.	2008
47	Bilateral Brown syndrome related to sinusitis. ( 19020644 )	Sturm V....StA1rmer J.	2008
48	Bilateral Brown syndrome in monozygotic twins. ( 18258471 )	Kim S.H....Neely D.E.	2008
49	Superior oblique tendon spacer with application of nonabsorbable adjustable suture for treatment of Brown syndrome. ( 18396080 )	Yazdian Z....Rajabi M.T.	2008
50	Familial unilateral Brown syndrome. ( 18711279 )		2008

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Genes for Brown Syndrome

Genes related to Brown Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PHOX2A	Paired Like Homeobox 2A	Protein Coding	16.45	GeneCards inferred via : Publications (show sections)
2	FBN2	Fibrillin 2	Protein Coding	16.45	GeneCards inferred via : Publications (show sections)
3	MRXSBWB	Brooks-Wisniewski-Brown Syndrome	Genetic Locus	8	GeneCards inferred via : Gene name (show sections)

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Variations for Brown Syndrome

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Expression for Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

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Pathways for Brown Syndrome

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GO Terms for Brown Syndrome

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Sources for Brown Syndrome

¹ BioSystems

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³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

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³⁸ LifeMap

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⁴¹ MalaCards

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⁴⁴ MeSH

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⁴⁸ NCBI Bookshelf

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⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

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⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

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⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Brown Syndrome (BRWNS)

Aliases & Classifications for Brown Syndrome

MalaCards integrated aliases for Brown Syndrome:

Characteristics:

OMIM:

HPO:

Classifications:

External Ids:

Summaries for Brown Syndrome

Related Diseases for Brown Syndrome

Diseases related to Brown Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Brown Syndrome:

Symptoms & Phenotypes for Brown Syndrome

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

UMLS symptoms related to Brown Syndrome:

Drugs & Therapeutics for Brown Syndrome

Interventional clinical trials:

Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

Publications for Brown Syndrome

Articles related to Brown Syndrome:

Genes for Brown Syndrome

Genes related to Brown Syndrome (0 elite genes):

Variations for Brown Syndrome

Expression for Brown Syndrome

Pathways for Brown Syndrome

GO Terms for Brown Syndrome

Sources for Brown Syndrome