BRWNS
MCID: BRW006
MIFTS: 29

Brown Syndrome (BRWNS)

Categories: Muscle diseases, Rare diseases

Aliases & Classifications for Brown Syndrome

MalaCards integrated aliases for Brown Syndrome:

Name: Brown Syndrome 58 77 54
Tendon Sheath Adherence, Superior Oblique 54
Superior Oblique Tendon Sheath Syndrome 54
Brown Tendon Sheath Syndrome 74
Brwns 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
noted in early childhood in most patients
some patients have onset in second decade of life


HPO:

33
brown syndrome:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 58 616407
MedGen 43 C0155339
SNOMED-CT via HPO 70 24982008 263681008
UMLS 74 C0155339

Summaries for Brown Syndrome

OMIM : 58 Brown syndrome, originally described by Brown (1950), is characterized by the inability to elevate the adducted eye actively or passively. There is less elevation deficit with the eye in midposition, and minimal or no deficit in abduction. There can also be divergence on upgaze, downshoot, or widening of the palpebral fissure on adduction, primary hypotropia, and anomalous head posture. Brown syndrome accounts for approximately 2% of strabismus cases. Ten percent of cases are bilateral, and left- and right-sided unilateral cases are equal in frequency. There is no gender predilection (summary by Heidary et al., 2012). (616407)

MalaCards based summary : Brown Syndrome, also known as tendon sheath adherence, superior oblique, is related to brooks-wisniewski-brown syndrome and spastic paraplegia facial cutaneous lesions, and has symptoms including spasm of conjugate gaze, pseudoophthalmoplegia and smooth pursuit deficiency. An important gene associated with Brown Syndrome is PHOX2A (Paired Like Homeobox 2A). Affiliated tissues include eye, and related phenotypes are diplopia and brown anomaly

NIH Rare Diseases : 54 Brown syndrome is an eye disorder characterized by abnormalities in the eye's ability to move. Specifically, the ability to look up and in is affected by a problem in the superior oblique muscle/tendon. The condition may be present at birth (congenital) or it may develop following surgery or as a result of inflammation or a problem with development. Some cases are constant while other are intermittent. Treatment depends upon the cause and severity of the movement disorder. Options include close observation, nonsteroidal anti-inflammatory agents like Ibuprofen, corticosteroids, and surgery.

Wikipedia : 77 Brown''s syndrome is a rare form of strabismus characterized by limited elevation of the affected eye.... more...

Related Diseases for Brown Syndrome

Graphical network of the top 20 diseases related to Brown Syndrome:



Diseases related to Brown Syndrome

Symptoms & Phenotypes for Brown Syndrome

Human phenotypes related to Brown Syndrome:

33
# Description HPO Frequency HPO Source Accession
1 diplopia 33 HP:0000651
2 brown anomaly 33 HP:0031622

Symptoms via clinical synopsis from OMIM:

58
Head And Neck Head:
chin-up head posture

Head And Neck Eyes:
limited or absent ability to elevate eye while in adducted (nasal) position

Clinical features from OMIM:

616407

UMLS symptoms related to Brown Syndrome:


spasm of conjugate gaze, pseudoophthalmoplegia, smooth pursuit deficiency

Drugs & Therapeutics for Brown Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Brown Syndrome

Genetic Tests for Brown Syndrome

Anatomical Context for Brown Syndrome

MalaCards organs/tissues related to Brown Syndrome:

42
Eye

Publications for Brown Syndrome

Articles related to Brown Syndrome:

(show top 50) (show all 87)
# Title Authors Year
1
Intratrochlear steroid injections in acquired Brown syndrome-a case series. ( 30611003 )
2019
2
Acquired reversible Brown syndrome caused by focal abscess of superior oblique muscle. ( 30710645 )
2019
3
Acquired Pediatric Brown Syndrome Secondary to Sinusitis. ( 30907972 )
2019
4
Magnetic Resonance Findings at 3 Tesla in Brown Syndrome. ( 29543977 )
2018
5
MRI of acquired Brown syndrome: a report of two cases. ( 29487642 )
2018
6
Brown Syndrome Following Upper Eyelid Ptosis Repair. ( 29467810 )
2018
7
Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. ( 30415012 )
2018
8
Consecutive superior oblique palsy after adjustable suture spacer surgery for Brown syndrome: incidence and predicting risk. ( 30236966 )
2018
9
Horizontal Deviations in Congenital Brown Syndrome. ( 29257185 )
2017
10
Sequential congenital and acquired presentation of bilateral Brown syndrome. ( 28577917 )
2017
11
Combined Brown syndrome and superior oblique palsy without a trochlear nerve: case report. ( 28841851 )
2017
12
Steroid intra-trochlear injection for the treatment of acquired Brown syndrome secondary to trochleitis. ( 28770346 )
2017
13
Surgical Management of Brown Syndrome. ( 29156074 )
2017
14
Resolution of acquired Brown syndrome with oral steroid therapy. ( 28757707 )
2017
15
Herpes zoster ophthalmicus and strabismus: a unique cause of secondary Brown syndrome. ( 28625469 )
2017
16
Acquired Brown Syndrome Treated With Traction of Superior Oblique Tendon. ( 26854770 )
2016
17
Brown syndrome with severe amblyopia: a case report from Africa. ( 26090014 )
2015
18
Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26397461 )
2015
19
Magnetic resonance imaging in congenital Brown syndrome. ( 25744329 )
2015
20
Three cases of acquired simulated brown syndrome after blowout fracture operations. ( 26015892 )
2015
21
Considerations on the etiology of congenital Brown syndrome. ( 26163776 )
2015
22
Erratum. Size of the Oblique Extraocular Muscles and Superior Oblique Muscle Contractility in Brown Syndrome. ( 26529043 )
2015
23
Clinical evolution of bilateral Brown syndrome. ( 25439308 )
2014
24
Trochlea surgery for acquired Brown syndrome. ( 24568984 )
2014
25
The results of Brown syndrome surgery with superior oblique split tendon lengthening. ( 24564724 )
2014
26
Clinical progression of untreated bilateral Brown syndrome. ( 24698613 )
2014
27
Ethmoidal sinus mucocele as a cause of acquired brown syndrome. ( 25276088 )
2014
28
Amblyopia and sensory features at initial presentation of Brown syndrome: an issue to recognize. ( 23370414 )
2013
29
Simulated Brown syndrome in the contralateral eye in superior oblique palsy. ( 22234524 )
2013
30
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
31
Possible association of congenital Brown syndrome with congenital cranial dysinnervation disorders. ( 23237754 )
2012
32
Sequential presentation of bilateral Brown syndrome. ( 22525185 )
2012
33
Absence of the fourth cranial nerve in congenital Brown syndrome. ( 22268674 )
2012
34
Pseudo-Brown syndrome: a potential ophthalmologic sequela after a transcaruncular-transconjunctival approach for orbital fracture repair. ( 22632930 )
2012
35
Superior oblique tendon expansion with Achilles tendon allograft for treating Brown syndrome. ( 21665503 )
2011
36
Congenital unilateral brown syndrome in non-twin siblings. ( 21766745 )
2011
37
Acquired Brown syndrome: report of two cases. ( 21907127 )
2011
38
Monocular partial/sector occlusion therapy: a procedure to inhibit diplopia in Brown syndrome. ( 21216206 )
2011
39
Late spontaneous resolution of congenital Brown syndrome. ( 21168089 )
2010
40
We are not ready to use palmaris longus tendon as an autogenous expander for Brown syndrome. ( 20451849 )
2010
41
Late spontaneous resolution of congenital Brown syndrome. ( 20637665 )
2010
42
Brown syndrome in one pair of dizygotic twins: a case report. ( 20076806 )
2010
43
A case of acquired Brown syndrome after surgical repair of a medial orbital wall fracture. ( 20157416 )
2010
44
Brown syndrome with bifid scleral insertion of the superior oblique. ( 19496499 )
2009
45
MR imaging features of acquired Brown syndrome. ( 19369611 )
2009
46
Spontaneous resolution in patients with congenital Brown syndrome. ( 19084441 )
2009
47
Brown syndrome--operate or observe? ( 19393508 )
2009
48
Management of Brown syndrome. ( 19085429 )
2008
49
Long-term results of an intraoperative adjustable superior oblique tendon suture spacer using nonabsorbable suture for Brown Syndrome. ( 18538400 )
2008
50
Bilateral Brown syndrome related to sinusitis. ( 19020644 )
2008

Variations for Brown Syndrome

Expression for Brown Syndrome

Search GEO for disease gene expression data for Brown Syndrome.

Pathways for Brown Syndrome

GO Terms for Brown Syndrome

Sources for Brown Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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