MCID: BRW002
MIFTS: 28

Brown's Tendon Sheath Syndrome

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Brown's Tendon Sheath Syndrome

MalaCards integrated aliases for Brown's Tendon Sheath Syndrome:

Name: Brown's Tendon Sheath Syndrome 12
Brown Tendon Sheath Syndrome 12 71
Ocular Motility Disorders 43 71
Brown's Sheath Syndrome 12
Brown's Sheath Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10235
ICD9CM 34 378.61
MeSH 43 D015835
SNOMED-CT 67 35929003
ICD10 32 H50.61
UMLS 71 C0028850 C0155339

Summaries for Brown's Tendon Sheath Syndrome

MalaCards based summary : Brown's Tendon Sheath Syndrome, also known as brown tendon sheath syndrome, is related to ocular motility disease and brown syndrome, and has symptoms including ophthalmoplegia, hyperexplexia and eye manifestations. The drugs Methamphetamine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and thyroid.

Related Diseases for Brown's Tendon Sheath Syndrome

Diseases related to Brown's Tendon Sheath Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 ocular motility disease 11.9
2 brown syndrome 11.6
3 fibrosis of extraocular muscles, congenital, 2 11.5
4 fibrosis of extraocular muscles, congenital, 1 11.3
5 fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement 11.2
6 fibrosis of extraocular muscles, congenital, 5 11.2
7 strabismus 10.4
8 mechanical strabismus 10.4
9 pathologic nystagmus 10.2
10 monocular esotropia 10.2
11 esotropia 10.2
12 duane retraction syndrome 1 10.1
13 kearns-sayre syndrome 10.1
14 ptosis 10.1
15 suppression amblyopia 10.1
16 amblyopia 10.1
17 alternating exotropia 10.1
18 exotropia 10.1
19 refractive error 10.1
20 abducens palsy 10.0
21 torticollis 10.0
22 ataxia and polyneuropathy, adult-onset 10.0
23 movement disease 10.0
24 internuclear ophthalmoplegia 10.0
25 hypotropia 10.0
26 seizures, benign familial neonatal, 1 9.8
27 multiple sclerosis 9.8
28 exudative vitreoretinopathy 1 9.8
29 retinal detachment 9.8
30 temporal arteritis 9.8
31 joubert syndrome 1 9.8
32 ocular motor apraxia 9.8
33 nonarteritic anterior ischemic optic neuropathy 9.8
34 retinitis pigmentosa 9.8
35 tukel syndrome 9.8
36 alacrima, achalasia, and mental retardation syndrome 9.8
37 joint laxity, short stature, and myopia 9.8
38 autosomal recessive disease 9.8
39 neuroretinitis 9.8
40 abducens nerve disease 9.8
41 myopia 9.8
42 vertebrobasilar insufficiency 9.8
43 optic nerve disease 9.8
44 pupil disease 9.8
45 cavernous sinus thrombosis 9.8
46 retinitis 9.8
47 ovary adenocarcinoma 9.8
48 blepharospasm 9.8
49 eye disease 9.8
50 orbital disease 9.8

Graphical network of the top 20 diseases related to Brown's Tendon Sheath Syndrome:



Diseases related to Brown's Tendon Sheath Syndrome

Symptoms & Phenotypes for Brown's Tendon Sheath Syndrome

UMLS symptoms related to Brown's Tendon Sheath Syndrome:


ophthalmoplegia, hyperexplexia, eye manifestations, deficiencies of smooth pursuit movements, spasm of conjugate gaze, anomalies of divergence, pseudoophthalmoplegia, smooth pursuit deficiency

Drugs & Therapeutics for Brown's Tendon Sheath Syndrome

Drugs for Brown's Tendon Sheath Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methamphetamine Approved, Illicit Phase 3 537-46-2 10836
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
rituximab Approved Phase 3 174722-31-7 10201696
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
7 Dopamine Agents Phase 3
8 Central Nervous System Stimulants Phase 3
9 Neurotransmitter Agents Phase 3
10 Adrenergic Agents Phase 3
11 Sympathomimetics Phase 3
12 Gastrointestinal Agents Phase 3
13 Antineoplastic Agents, Immunological Phase 3
14 Hormones Phase 3
15 Antineoplastic Agents, Hormonal Phase 3
16
protease inhibitors Phase 3
17 Alkylating Agents Phase 3
18 Antiemetics Phase 3
19 Immunosuppressive Agents Phase 3
20 Hormone Antagonists Phase 3
21 HIV Protease Inhibitors Phase 3
22 glucocorticoids Phase 3
23 BB 1101 Phase 3
24 Anti-Inflammatory Agents Phase 3
25 Antirheumatic Agents Phase 3
26 Immunologic Factors Phase 3
27
4-Aminopyridine Approved Phase 2 504-24-5 1727
28
Carmustine Approved, Investigational Phase 2 154-93-8 2578
29
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
30
Etoposide Approved Phase 2 33419-42-0 36462
31
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
32
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
33
Melphalan Approved Phase 2 148-82-3 460612 4053
34
Phenylalanine Approved, Investigational, Nutraceutical Phase 2 63-91-2 6140
35
Cortisone Experimental Phase 2 53-06-5 222786
36 Potassium Channel Blockers Phase 2
37 Etoposide phosphate Phase 2
38 Anti-Infective Agents Phase 2
39 Nitrogen Mustard Compounds Phase 2
40 Dermatologic Agents Phase 2
41 Antiviral Agents Phase 2
42 Thymoglobulin Phase 2
43 Podophyllotoxin Phase 2 518-28-5
44 Tubulin Modulators Phase 2
45 Keratolytic Agents Phase 2
46 Antimetabolites Phase 2
47 Antimitotic Agents Phase 2
48 Antilymphocyte Serum Phase 2
49
L-Alanine Nutraceutical Phase 2 56-41-7 5950
50
Acetylcholine Approved, Investigational 51-84-3 187

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Convergence Insufficiency Treatment Trial (CITT) Unknown status NCT00338611 Phase 3
2 A Randomized Clinical Trial of the Effectiveness of Base-in Prism Reading Glasses Vs. Placebo Reading Glasses for Symptomatic Convergence Insufficiency in Children Completed NCT00347581 Phase 3
3 A Randomized Clinical Trial of Pencil Push-Ups Versus Office Based Vision Therapy For the Treatment of Convergence Insufficiency Completed NCT00347945 Phase 3
4 Multinational European Trial for Children With the Opsoclonus Myoclonus Syndrome / Dancing Eye Syndrome Recruiting NCT01868269 Phase 3 Dexamethasone acetate;dexamethasone and cyclophosphamide;dexamethasone and rituximab
5 Convergence Insufficiency Treatment Trial - Attention and Reading Trial (CITT-ART) Active, not recruiting NCT02207517 Phase 3
6 Interventions for Convergence Insufficiency in Concussed Children (ICONICC) Not yet recruiting NCT03908112 Phase 3
7 Comparison of Three Vision Therapy Approaches for Convergence Insufficiency Unknown status NCT03431454 Phase 2
8 Use of Rituximab in Opsoclonus-Myoclonus in Children With Neuroblastoma Unknown status NCT00202930 Phase 2 anti-CD20 (Rituximab)
9 A Phase I Clinical Trial of Rituximab for Pediatric Opsoclonus-Myoclonus Syndrome Completed NCT00244361 Phase 1, Phase 2 rituximab
10 Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis Completed NCT02391961 Phase 2 Dalfampridine;Placebo
11 High-Dose Immunosuppressive Therapy Using Carmustine, Etoposide, Cytarabine, and Melphalan (BEAM) + Thymoglobulin Followed by Syngeneic or Autologous Hematopoietic Cell Transplantation for Patients With Autoimmune Neurologic Diseases Recruiting NCT00716066 Phase 2 Carmustine;Cytarabine;Etoposide;Melphalan;Prednisone
12 Oculomotor Training Improves Reading Eye Movement Unknown status NCT02981875
13 Treatment for Convergence Insufficiency Intermittent Exotropia; A Randomized Trial Completed NCT01435876
14 Study of Eyes and Attention Deficit (SEAD) Completed NCT00472511
15 Screening Eye Coordination Study Screening for Convergence Insufficiency in School-age Children Completed NCT00472407
16 Frontoparietal Priority Maps as Biomarkers for MTBI Completed NCT02251002
17 A Prospective Observational Study of Adult Strabismus Completed NCT02510040
18 Cytokines as Biomarkers and Therapeutic Targets in Paraneoplastic Opsoclonus-Myoclonus Syndrome (OMS) Completed NCT00806182
19 Evaluation and Treatment Protocol for Patients With Pediatric Eye Diseases and Strabismus Completed NCT00006422
20 Functional Neural Mechanism of Vision Therapy for Patients With Convergence Insufficiency Completed NCT03593031
21 A School-based Intervention to Diagnose and Treat Vision Problems in Elementary School Children With Reading Difficulty Completed NCT02607384
22 Effectiveness of Home-Based Therapy for Symptomatic Convergence Insufficiency Completed NCT01515943
23 Spectacles Lens in Concussed Kids Recruiting NCT03123822
24 Objective Assessment of Disparity Vergence After Treatment of Symptomatic Convergence Insufficiency (CI) in Children Recruiting NCT03248336
25 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
26 Slanted Bilateral Lateral Rectus Recession Versus Conventional Bilateral Lateral Rectus Recession for Convergence Insufficiency Intermittent Exotropia in Children Recruiting NCT04064112
27 Eyetracking and Neurovision Rehabilitation of Oculomotor Dysfunction in Mild Traumatic Brain Injury Recruiting NCT03319966
28 The Development of an Artificial Intelligence Platform for Screening and Referral of Cognitive Dysfunction Not yet recruiting NCT04236375

Search NIH Clinical Center for Brown's Tendon Sheath Syndrome

Cochrane evidence based reviews: ocular motility disorders

Genetic Tests for Brown's Tendon Sheath Syndrome

Anatomical Context for Brown's Tendon Sheath Syndrome

MalaCards organs/tissues related to Brown's Tendon Sheath Syndrome:

40
Eye, Brain, Thyroid, Testes, Heart, Pituitary

Publications for Brown's Tendon Sheath Syndrome

Articles related to Brown's Tendon Sheath Syndrome:

(show top 50) (show all 145)
# Title Authors PMID Year
1
[Ocular Motor Nerve Palsies Caused by Paragliding Accidents]. 61
32131125 2020
2
Binocular, Accommodative and Oculomotor Alterations In Multiple Sclerosis: A Review. 61
32228341 2020
3
Longstanding diplopia after ethmoidal artery ligation for epistaxis. 61
31667574 2020
4
Severe Acquired Restrictive Strabismus Fixus in Patients with Trisomy 21. 61
31584357 2019
5
[Ocular manifestations in Ehlers-Danlos Syndromes: Clinical study of 21 patients]. 61
31133401 2019
6
Correlation between Intraocular Pressure and Thickness of Extraocular Muscles, the Severity and Activity of Thyroid-associated Orbitopathy. 61
31237847 2019
7
Causes and surgical treatment of diplopia and strabismus secondary to myasthenia gravis. 61
30580990 2019
8
Correction to: development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures. 61
30857536 2019
9
Development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures. 61
30736755 2019
10
Resting cerebral blood flow alterations specific to the comitant exophoria patients revealed by arterial spin labeling perfusion magnetic resonance imaging. 61
29991447 2018
11
Recurrent isolated oculomotor nerve palsy caused by schwannoma in a pediatric patient. 61
30127176 2018
12
[Four Cases of Wernicke's Encephalopathy Following Hematopoietic Stem Cell Transplantation]. 61
29950237 2018
13
Retinal and optic nerve degeneration in α-mannosidosis. 61
29859105 2018
14
A cohort study on acute ocular motility disorders in pediatric emergency department. 61
29843812 2018
15
Comparative Study of the Usefulness of the Binocular Spot Vision Screener Autorefractor in the Detection of Childhood Visual Disorders. 61
29590687 2018
16
Symptomatic accommodative and binocular dysfunctions from the use of flat-panel displays. 61
29600186 2018
17
Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study. 61
28679330 2018
18
Prevalence and severity of ocular involvement in Graves' disease according to sex and age: A clinical study from Babol, Iran. 61
29732037 2018
19
Clinical versus Evidence-based Rehabilitation Options for Post-stroke Visual Impairment. 61
29344068 2017
20
Vision In Stroke cohort: Profile overview of visual impairment. 61
29201538 2017
21
The atrophy of white and gray matter volume in patients with comitant strabismus: Evidence from a voxel-based morphometry study. 61
28713925 2017
22
[Clinical analysis of orbital and periorbital abscess in 17 patients]. 61
28851199 2017
23
Correlations between dental malocclusions, ocular motility, and convergence disorders: a cross-sectional study in growing subjects. 61
29285332 2017
24
Axons get ahead: Insights into axon guidance and congenital cranial dysinnervation disorders. 61
28033651 2017
25
Burden of Ocular Motility Disorders at a Tertiary Care Institution: A Case to Enhance Secondary Level Eye Care. 61
27051084 2016
26
Varicella zoster virus rhombencephalomyelitis following radiation therapy for oropharyngeal carcinoma. 61
26602800 2016
27
[Ocular Motility Disorders with Diplopia Like the first Symptoms of Paranasal Tumours with Orbital Invasion - a Case Report]. 61
27860481 2016
28
Microstructural changes of the whole brain in patients with comitant strabismus: evidence from a diffusion tensor imaging study. 61
27574432 2016
29
Progressive Multifocal Leukoencephalopathy: Recent Advances and a Neuro-Ophthalmological Review. 61
26132966 2015
30
Modified Y-splitting Procedure for the Treatment of Duane Retraction Syndrome. 61
27800223 2015
31
Development of an interactive anatomical three-dimensional eye model. 61
25228501 2015
32
Controversies in orbital reconstruction--II. Timing of post-traumatic orbital reconstruction: a systematic review. 61
25543904 2015
33
[Congenital cranial dysinnervation disorders (CCDD)]. 61
25803556 2015
34
Medical and Surgical Treatment in Pediatric Orbital Myositis Associated with Coxsackie Virus. 61
26550508 2015
35
Brown syndrome with severe amblyopia: a case report from Africa. 61
26090014 2015
36
CCDD Phenotype Associated with a Small Chromosome 2 Deletion. 61
24475916 2015
37
Congenital and Genetic Ocular Motility Disorders: Update and Considerations. 61
26564928 2015
38
Myopia, visual acuity and strabismus in the long term following treatment of retinopathy of prematurity. 61
26022588 2014
39
[Oculomotor system and multiple sclerosis]. 61
25074654 2014
40
[Sclerotization of orbital lymphangioma with OK-432]. 61
24706253 2014
41
Reading networks in children with dyslexia compared to children with ocular motility disturbances revealed by fMRI. 61
25477808 2014
42
[Vertigo and dizziness. Ophthalmological addendum]. 61
23329118 2013
43
Ocular myasthenia gravis. 61
23047171 2012
44
[Surgical treatment of large or giant cavernous sinus hemangiomas via epidural approach]. 61
23157906 2012
45
Acute polyradiculoneuritis syndrome: clinical observations and differential diagnosis. 61
23115942 2012
46
[Diplopia as a factor influencing occupational and social activities of people after orbital trauma]. 61
23373322 2012
47
Reconstruction of complex orbital fracture with titanium implants. 61
22937511 2012
48
Recent progress in understanding congenital cranial dysinnervation disorders. 61
21317732 2011
49
Situational restriction: using your physical exam to differentiate pulley abnormalities from other vertical deviations secondary to restrictive conditions. 61
22069845 2011
50
The use of dynamic magnetic resonance in the diagnosis of ocular motility disorders. 61
21853952 2011

Variations for Brown's Tendon Sheath Syndrome

Expression for Brown's Tendon Sheath Syndrome

Search GEO for disease gene expression data for Brown's Tendon Sheath Syndrome.

Pathways for Brown's Tendon Sheath Syndrome

GO Terms for Brown's Tendon Sheath Syndrome

Sources for Brown's Tendon Sheath Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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