Bruck Syndrome 2 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

BRKS2 MCID: BRC048 MIFTS: 32	Bruck Syndrome 2 (BRKS2) Categories: Bone diseases, Fetal diseases, Genetic diseases, Oral diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Expand all tables

Sources

Aliases & Classifications for Bruck Syndrome 2

MalaCards integrated aliases for Bruck Syndrome 2:

Name: Bruck Syndrome 2 ⁵⁷ ²⁰ ⁷² ²⁹ ¹³ ⁶ ⁷⁰

Osteogenesis Imperfecta with Congenital Joint Contractures ⁵⁷ ⁷² ⁶

Brks2 ⁵⁷ ²⁰ ⁷²

Syndrome, Bruck, Type 2 ³⁹

Characteristics:

OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Inheritance:
autosomal recessive

HPO:

³¹

bruck syndrome 2:
Inheritance autosomal recessive inheritance

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases Fetal diseases
Anatomical: Bone diseases Oral diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM® ⁵⁷ 609220

MeSH ⁴⁴ D001176 D010009

MedGen ⁴¹ C1836602

UMLS ⁷⁰ C1836602

Sources

Summaries for Bruck Syndrome 2

UniProtKB/Swiss-Prot : ⁷² Bruck syndrome 2: An autosomal recessive disease characterized by generalized osteopenia, congenital joint contractures, fragile bones with onset of fractures in infancy or early childhood, short stature, severe limb deformity, progressive scoliosis, and pterygia. It is distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations.

MalaCards based summary : Bruck Syndrome 2, also known as osteogenesis imperfecta with congenital joint contractures, is related to dentinogenesis imperfecta and bruck syndrome. An important gene associated with Bruck Syndrome 2 is PLOD2 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2). Affiliated tissues include bone, and related phenotypes are osteopenia and inguinal hernia

More information from OMIM: 609220

Sources

Related Diseases for Bruck Syndrome 2

Diseases in the Bruck Syndrome family:

Bruck Syndrome 1

Bruck Syndrome 2

Diseases related to Bruck Syndrome 2 via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)

#	Related Disease	Score	Top Affiliating Genes
1	dentinogenesis imperfecta	30.2	PLOD2 FKBP10
2	bruck syndrome	29.6	PLOD2 FKBP10
3	brittle bone disorder	29.5	PLOD2 FKBP10
4	scoliosis	29.2	PLOD2 FKBP10
5	bruck syndrome 1	11.1
6	torticollis	10.3
7	congenital amyoplasia	10.3
8	cleft soft palate	10.0
9	protrusio acetabuli	10.0
10	velocardiofacial syndrome	10.0
11	congenital contractures	10.0
12	osteogenesis imperfecta, type iii	9.7	PLOD2 FKBP10
13	multiple pterygium syndrome, escobar variant	9.7	PLOD2 FKBP10
14	odontochondrodysplasia	9.6	PLOD2 FKBP10

Graphical network of the top 20 diseases related to Bruck Syndrome 2:

Sources

Symptoms & Phenotypes for Bruck Syndrome 2

Human phenotypes related to Bruck Syndrome 2:

³¹ (show all 14)

#	Description	HPO Source Accession
1	osteopenia ³¹	HP:0000938
2	inguinal hernia ³¹	HP:0000023
3	pectus carinatum ³¹	HP:0000768
4	short stature ³¹	HP:0004322
5	flexion contracture ³¹	HP:0001371
6	elbow flexion contracture ³¹	HP:0002987
7	talipes equinovarus ³¹	HP:0001762
8	platyspondyly ³¹	HP:0000926
9	wormian bones ³¹	HP:0002645
10	pterygium ³¹	HP:0001059
11	knee flexion contracture ³¹	HP:0006380
12	femoral bowing ³¹	HP:0002980
13	increased susceptibility to fractures ³¹	HP:0002659
14	hydroxyprolinuria ³¹	HP:0003080

Symptoms via clinical synopsis from OMIM®:

⁵⁷ (Updated 05-Apr-2021)

Skeletal:
osteopenia
bone fragility
congenital joint contracture (elbow and knees)

Chest Ribs Sternum Clavicles And Scapulae:
pectus carinatum

Skeletal Skull:
wormian bones

Skeletal Feet:
clubfeet

Skin Nails Hair Skin:
pterygia

Genitourinary External Genitalia Male:
inguinal hernia

Growth Height:
short stature

Skeletal Limbs:
femoral bowing

Laboratory Abnormalities:
elevated urinary hydroxyproline

Skeletal Spine:
platyspondyly (thoracic vertebrae)

Clinical features from OMIM®:

609220 (Updated 05-Apr-2021)

Sources

Drugs & Therapeutics for Bruck Syndrome 2

Search Clinical Trials , NIH Clinical Center for Bruck Syndrome 2

Sources

Genetic Tests for Bruck Syndrome 2

Genetic tests related to Bruck Syndrome 2:

#	Genetic test	Affiliating Genes
1	Bruck Syndrome 2 ²⁹	PLOD2

Sources

Anatomical Context for Bruck Syndrome 2

MalaCards organs/tissues related to Bruck Syndrome 2:

⁴⁰

Bone

Sources

Publications for Bruck Syndrome 2

Articles related to Bruck Syndrome 2:

(show all 16)

#	Title	Authors	PMID	Year
1	Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome--osteogenesis imperfecta phenotypic spectrum. ⁵⁷ ⁶	Puig-Hervas MT...Ruiz-Perez VL	22689593	2012
2	Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2. ⁵⁷ ⁶	Ha-Vinh R...Bonafe L	15523624	2004
3	Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis. ⁵⁷ ⁶	van der Slot AJ...Bank RA	12881513	2003
4	Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17. ⁶ ⁵⁷	Bank RA...TeKoppele JM	9927692	1999
5	Kuskokwim syndrome, a recessive congenital contracture disorder, extends the phenotype of FKBP10 mutations. ⁶	Barnes AM...Marini JC	23712425	2013
6	Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen. ⁶	Schwarze U...Byers PH	22949511	2013
7	Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix. ⁶	Barnes AM...Marini JC	22718341	2012
8	Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. ⁶	Shaheen R...Alkuraya FS	21567934	2011
9	Mutations in FKBP10 cause recessive osteogenesis imperfecta and Bruck syndrome. ⁶	Kelley BP...Lee B	20839288	2011
10	FKBP10 and Bruck syndrome: phenotypic heterogeneity or call for reclassification? ⁶	Shaheen R...Alkuraya FS	20696291	2010
11	Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. ⁶	Alanay Y...Krakow D	20362275	2010
12	Bruck syndrome: a rare combination of bone fragility and multiple congenital joint contractures. ⁶	Breslau-Siderius EJ...van der Sluijs JA	9481655	1998
13	Bruck syndrome (osteogenesis imperfecta with congenital joint contractures): review and report on the first North American case. ⁶	McPherson E...Clemens M	9129737	1997
14	Case Report: Exome Sequencing Identified a Novel Compound Heterozygous Variation in PLOD2 Causing Bruck Syndrome Type 2. ⁶¹	Zhang J...Guo Q	33664768	2021
15	Bruck syndrome 2 variant lacking congenital contractures and involving a novel compound heterozygous PLOD2 mutation. ⁶¹	Mumm S...Whyte MP	31472299	2020
16	Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2. ⁶¹	Leal GF...Tham E	29178448	2018

Sources

Genes for Bruck Syndrome 2

Genes related to Bruck Syndrome 2 (2 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	PLOD2	Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 2	Protein Coding	1343.84	Molecular basis known ⁵⁷ Pathogenic ⁶ Causative variation ⁷² Genetic Tests ²⁹ Likely pathogenic ⁶ GeneCards inferred via : Disorders Variants (show sections)	12881513
2	FKBP10	FKBP Prolyl Isomerase 10	Protein Coding	425	Pathogenic ⁶ Likely pathogenic ⁶	23712425 9129737 22949511 (more) 20362275 20839288 21567934 22689593 22718341 9481655 9927692 20696291

Sources

Variations for Bruck Syndrome 2

ClinVar genetic disease variations for Bruck Syndrome 2:

⁶ (show top 50) (show all 95)

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	Position
1	PLOD2	NM_182943.3(PLOD2):c.1886C>T (p.Thr629Ile)	SNV	Pathogenic	7641	rs121434459	GRCh37: 3:145789173-145789173 GRCh38: 3:146071386-146071386
2	PLOD2	NM_182943.3(PLOD2):c.1865G>T (p.Gly622Val)	SNV	Pathogenic	7642	rs121434460	GRCh37: 3:145789194-145789194 GRCh38: 3:146071407-146071407
3	PLOD2	NM_182943.3(PLOD2):c.1856G>A (p.Arg619His)	SNV	Pathogenic	7643	rs121434461	GRCh37: 3:145789203-145789203 GRCh38: 3:146071416-146071416
4	FKBP10	FKBP10, 8-BP DUP, NT1016	Duplication	Pathogenic	30631		GRCh37: GRCh38:
5	FKBP10	NM_021939.3(FKBP10):c.1276dup (p.Gln426fs)	Duplication	Pathogenic	30633	rs1567856056	GRCh37: 17:39977212-39977213 GRCh38: 17:41820960-41820961
6	FKBP10	NM_021939.3(FKBP10):c.344G>A (p.Arg115Gln)	SNV	Pathogenic	30634	rs387906960	GRCh37: 17:39973408-39973408 GRCh38: 17:41817156-41817156
7	FKBP10	NM_021939.3(FKBP10):c.743dup (p.Gln249fs)	Duplication	Pathogenic	30635	rs1555616552	GRCh37: 17:39975471-39975472 GRCh38: 17:41819219-41819220
8	PLOD2	NM_182943.3(PLOD2):c.1559dup (p.Val523fs)	Duplication	Pathogenic	41424	rs749709000	GRCh37: 3:145795652-145795653 GRCh38: 3:146077865-146077866
9	FKBP10	NM_021939.3(FKBP10):c.1271_1272delinsA (p.Ala424fs)	Indel	Pathogenic	41425	rs397509383	GRCh37: 17:39977213-39977214 GRCh38: 17:41820961-41820962
10	FKBP10	NM_021939.3(FKBP10):c.831dup (p.Gly278fs)	Duplication	Pathogenic	438659	rs137853883	GRCh37: 17:39975558-39975559 GRCh38: 17:41819306-41819307
11	FKBP10	NM_021939.3(FKBP10):c.337G>A (p.Glu113Lys)	SNV	Pathogenic	41473	rs397514674	GRCh37: 17:39973401-39973401 GRCh38: 17:41817149-41817149
12	FKBP10	NM_021939.3(FKBP10):c.877_879del (p.Tyr293del)	Deletion	Pathogenic	208427	rs869320752	GRCh37: 17:39975609-39975611 GRCh38: 17:41819357-41819359
13	FKBP10	NM_021939.4(FKBP10):c.921C>G (p.Tyr307Ter)	SNV	Pathogenic	1028229		GRCh37: 17:39975785-39975785 GRCh38: 17:41819533-41819533
14	PLOD2	NM_182943.3(PLOD2):c.1280A>G (p.Asn427Ser)	SNV	Likely pathogenic	807467	rs893004444	GRCh37: 3:145799603-145799603 GRCh38: 3:146081816-146081816
15	PLOD2	NM_182943.3(PLOD2):c.351dup (p.Phe118fs)	Duplication	Likely pathogenic	930725		GRCh37: 3:145828222-145828223 GRCh38: 3:146110435-146110436
16	FKBP10	NM_021939.3(FKBP10):c.890_897dup (p.Gly300Ter)	Duplication	Likely pathogenic	631496	rs1567855132	GRCh37: 17:39975623-39975624 GRCh38: 17:41819371-41819372
17	PLOD2	NM_182943.3(PLOD2):c.2110G>A (p.Glu704Lys)	SNV	Uncertain significance	900155		GRCh37: 3:145788840-145788840 GRCh38: 3:146071053-146071053
18	PLOD2	NM_182943.3(PLOD2):c.1658A>G (p.Gln553Arg)	SNV	Uncertain significance	343646	rs148051196	GRCh37: 3:145794588-145794588 GRCh38: 3:146076801-146076801
19	PLOD2	NM_182943.3(PLOD2):c.382A>G (p.Lys128Glu)	SNV	Uncertain significance	343651	rs200569129	GRCh37: 3:145828192-145828192 GRCh38: 3:146110405-146110405
20	PLOD2	NM_182943.3(PLOD2):c.-73C>T	SNV	Uncertain significance	343653	rs148948195	GRCh37: 3:145878849-145878849 GRCh38: 3:146161062-146161062
21	PLOD2	NM_182943.3(PLOD2):c.801C>A (p.Asn267Lys)	SNV	Uncertain significance	545697	rs771710305	GRCh37: 3:145809665-145809665 GRCh38: 3:146091878-146091878
22	PLOD2	NM_182943.3(PLOD2):c.533G>A (p.Arg178His)	SNV	Uncertain significance	343649	rs143513488	GRCh37: 3:145824401-145824401 GRCh38: 3:146106614-146106614
23	PLOD2	NM_182943.3(PLOD2):c.2121+14T>C	SNV	Uncertain significance	343644	rs376009508	GRCh37: 3:145788815-145788815 GRCh38: 3:146071028-146071028
24	PLOD2	NM_182943.3(PLOD2):c.*809T>C	SNV	Uncertain significance	343636	rs540984133	GRCh37: 3:145787695-145787695 GRCh38: 3:146069908-146069908
25	PLOD2	NM_182943.3(PLOD2):c.*1211C>T	SNV	Uncertain significance	343633	rs886058061	GRCh37: 3:145787293-145787293 GRCh38: 3:146069506-146069506
26	PLOD2	NM_182943.3(PLOD2):c.*1157T>C	SNV	Uncertain significance	343634	rs569145930	GRCh37: 3:145787347-145787347 GRCh38: 3:146069560-146069560
27	PLOD2	NM_000935.2(PLOD2):c.-322G>T	SNV	Uncertain significance	343658	rs550383313	GRCh37: 3:145879098-145879098 GRCh38: 3:146161311-146161311
28	PLOD2	NM_182943.3(PLOD2):c.*292C>T	SNV	Uncertain significance	343640	rs886058063	GRCh37: 3:145788212-145788212 GRCh38: 3:146070425-146070425
29	PLOD2	NM_182943.3(PLOD2):c.-95G>A	SNV	Uncertain significance	343655	rs368041250	GRCh37: 3:145878871-145878871 GRCh38: 3:146161084-146161084
30	PLOD2	NM_000935.2(PLOD2):c.-478G>C	SNV	Uncertain significance	343661	rs886058067	GRCh37: 3:145879254-145879254 GRCh38: 3:146161467-146161467
31	PLOD2	NM_182943.3(PLOD2):c.616-13T>A	SNV	Uncertain significance	343648	rs149019740	GRCh37: 3:145822142-145822142 GRCh38: 3:146104355-146104355
32	PLOD2	NM_182943.3(PLOD2):c.*683C>T	SNV	Uncertain significance	343638	rs566705549	GRCh37: 3:145787821-145787821 GRCh38: 3:146070034-146070034
33	PLOD2	NM_182943.3(PLOD2):c.-170C>G	SNV	Uncertain significance	343656	rs527384365	GRCh37: 3:145878946-145878946 GRCh38: 3:146161159-146161159
34	PLOD2	NM_182943.3(PLOD2):c.-81C>T	SNV	Uncertain significance	343654	rs886058065	GRCh37: 3:145878857-145878857 GRCh38: 3:146161070-146161070
35	PLOD2	NM_000935.2(PLOD2):c.-455C>T	SNV	Uncertain significance	343660	rs886058066	GRCh37: 3:145879231-145879231 GRCh38: 3:146161444-146161444
36	PLOD2	NM_182943.3(PLOD2):c.1732A>G (p.Ile578Val)	SNV	Uncertain significance	343645	rs558336915	GRCh37: 3:145791085-145791085 GRCh38: 3:146073298-146073298
37	PLOD2	NM_182943.3(PLOD2):c.*587G>A	SNV	Uncertain significance	343639	rs886058062	GRCh37: 3:145787917-145787917 GRCh38: 3:146070130-146070130
38	PLOD2	NM_182943.3(PLOD2):c.*148T>C	SNV	Uncertain significance	343642	rs886058064	GRCh37: 3:145788356-145788356 GRCh38: 3:146070569-146070569
39	PLOD2	NM_182943.3(PLOD2):c.471G>A (p.Val157=)	SNV	Uncertain significance	343650	rs761346369	GRCh37: 3:145828103-145828103 GRCh38: 3:146110316-146110316
40	PLOD2	NM_182943.3(PLOD2):c.306T>A (p.Asp102Glu)	SNV	Uncertain significance	343652	rs764056697	GRCh37: 3:145838931-145838931 GRCh38: 3:146121144-146121144
41	FKBP10	NM_021939.4(FKBP10):c.1149G>T (p.Arg383Ser)	SNV	Uncertain significance	982765		GRCh37: 17:39976606-39976606 GRCh38: 17:41820354-41820354
42	PLOD2	NM_182943.3(PLOD2):c.778-6T>G	SNV	Uncertain significance	981530		GRCh37: 3:145809694-145809694 GRCh38: 3:146091907-146091907
43	PLOD2	NM_182943.3(PLOD2):c.2270A>T (p.Asp757Val)	SNV	Uncertain significance	981531		GRCh37: 3:145788511-145788511 GRCh38: 3:146070724-146070724
44	PLOD2	NM_182943.3(PLOD2):c.1457A>G (p.Lys486Arg)	SNV	Uncertain significance	343647	rs760876151	GRCh37: 3:145796946-145796946 GRCh38: 3:146079159-146079159
45	PLOD2	NM_182943.3(PLOD2):c.1417C>T (p.Arg473Ter)	SNV	Uncertain significance	632404	rs750664256	GRCh37: 3:145796986-145796986 GRCh38: 3:146079199-146079199
46	PLOD2	NM_182943.3(PLOD2):c.836G>A (p.Cys279Tyr)	SNV	Uncertain significance	901869		GRCh37: 3:145809630-145809630 GRCh38: 3:146091843-146091843
47	PLOD2	NM_182943.3(PLOD2):c.*63T>G	SNV	Uncertain significance	902704		GRCh37: 3:145788441-145788441 GRCh38: 3:146070654-146070654
48	PLOD2	NM_182943.3(PLOD2):c.*25A>C	SNV	Uncertain significance	902706		GRCh37: 3:145788479-145788479 GRCh38: 3:146070692-146070692
49	PLOD2	NM_182943.3(PLOD2):c.335A>G (p.Glu112Gly)	SNV	Uncertain significance	902770		GRCh37: 3:145838902-145838902 GRCh38: 3:146121115-146121115
50	PLOD2	NM_182943.3(PLOD2):c.121G>A (p.Val41Ile)	SNV	Uncertain significance	902771		GRCh37: 3:145842005-145842005 GRCh38: 3:146124218-146124218

UniProtKB/Swiss-Prot genetic disease variations for Bruck Syndrome 2:

⁷²

#	Symbol	AA change	Variation ID	SNP ID
1	PLOD2	p.Arg598His	VAR_022164	rs121434461
2	PLOD2	p.Gly601Val	VAR_022165	rs121434460
3	PLOD2	p.Thr608Ile	VAR_022166	rs121434459
4	PLOD2	p.Gly601Cys	VAR_069531	rs762788421

Sources

Expression for Bruck Syndrome 2

Search GEO for disease gene expression data for Bruck Syndrome 2.

Sources

Pathways for Bruck Syndrome 2

Sources

GO Terms for Bruck Syndrome 2

Biological processes related to Bruck Syndrome 2 according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peptidyl-lysine hydroxylation	GO:0017185	8.62	PLOD2 FKBP10

Sources

Sources for Bruck Syndrome 2

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia

Bruck Syndrome 2 (BRKS2)

Aliases & Classifications for Bruck Syndrome 2

MalaCards integrated aliases for Bruck Syndrome 2:

Characteristics:

OMIM®:

HPO:

Classifications:

External Ids:

Summaries for Bruck Syndrome 2

Related Diseases for Bruck Syndrome 2

Diseases in the Bruck Syndrome family:

Diseases related to Bruck Syndrome 2 via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Bruck Syndrome 2:

Symptoms & Phenotypes for Bruck Syndrome 2

Human phenotypes related to Bruck Syndrome 2:

Symptoms via clinical synopsis from OMIM®:

Clinical features from OMIM®:

Drugs & Therapeutics for Bruck Syndrome 2

Genetic Tests for Bruck Syndrome 2

Genetic tests related to Bruck Syndrome 2:

Anatomical Context for Bruck Syndrome 2

MalaCards organs/tissues related to Bruck Syndrome 2:

Publications for Bruck Syndrome 2

Articles related to Bruck Syndrome 2:

Genes for Bruck Syndrome 2

Genes related to Bruck Syndrome 2 (2 elite genes):

Variations for Bruck Syndrome 2

ClinVar genetic disease variations for Bruck Syndrome 2:

UniProtKB/Swiss-Prot genetic disease variations for Bruck Syndrome 2:

Expression for Bruck Syndrome 2

Pathways for Bruck Syndrome 2

GO Terms for Bruck Syndrome 2

Biological processes related to Bruck Syndrome 2 according to GeneCards Suite gene sharing:

Sources for Bruck Syndrome 2