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MCID: BRX001
MIFTS: 51

Bruxism

Categories: Mental diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bruxism

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MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 56 6 45 15 74
Sleep Bruxism 45 74
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 74
Grinding Teeth 12
Teeth Grinding 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:2846
ICD9CM 36 327.53
NCIt 51 C73511
SNOMED-CT 69 90207007
ICD10 34 F45.8 G47.63
Sources

Summaries for Bruxism

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Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to encephalopathy and disease of mental health, and has symptoms including excessive daytime somnolence, snoring and sleep disturbances. An important gene associated with Bruxism is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Monoamine GPCRs and DARPP-32 Phosphorylation. The drugs Acetylcholine and Trazodone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related phenotype is behavior/neurological.

Wikipedia : 77 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

Sources

Related Diseases for Bruxism

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Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 encephalopathy 30.0 CDKL5 FRRS1L MECP2
2 disease of mental health 29.8 DRD2 DRD3 HTR2A MECP2
3 attention deficit-hyperactivity disorder 29.8 DRD2 DRD3 DRD5 HTR2A MECP2
4 migraine with or without aura 1 29.8 DRD2 DRD3 DRD5 HTR2A
5 parasomnia, sleep bruxism type 12.5
6 cdkl5 deficiency disorder 11.2
7 oromandibular dystonia 11.1
8 tibial muscular dystrophy, tardive 10.4
9 anxiety 10.4
10 headache 10.4
11 sleep apnea 10.4
12 substance-induced psychosis 10.4 DRD2 HTR2A
13 early-onset schizophrenia 10.3 DRD2 HTR2A
14 gait apraxia 10.3 CDKL5 MECP2
15 polysubstance abuse 10.3 DRD2 DRD3
16 delusional disorder 10.3 DRD2 DRD3
17 alcoholic psychosis 10.3 DRD2 HTR2A
18 periodic limb movement disorder 10.3 DRD2 HTR2A
19 impulse control disorder 10.3 DRD2 DRD3
20 drug-induced mental disorder 10.3 DRD2 HTR2A
21 drug psychosis 10.3 DRD2 HTR2A
22 gastroesophageal reflux 10.2
23 periodontal disease 10.2
24 depression 10.2
25 infantile hypotonia 10.2 MECP2 UNC80
26 dystonia 10.2
27 progressive multifocal leukoencephalopathy 10.2 HTR2A MECP2
28 tic disorder 10.2 DRD2 DRD5 HTR2A
29 tardive dyskinesia 10.2 DRD2 DRD3 HTR2A
30 specific developmental disorder 10.2 CDKL5 DRD5 MECP2
31 pathological gambling 10.2 DRD2 DRD3 HTR2A
32 schizoaffective disorder 10.2 DRD2 DRD3 HTR2A
33 alcohol abuse 10.2 DRD2 DRD3 HTR2A
34 substance abuse 10.2 DRD2 DRD3 DRD5
35 brain injury 10.2
36 cerebral palsy 10.2
37 substance dependence 10.2 DRD2 DRD3 DRD5
38 mood disorder 10.2 DRD2 DRD3 HTR2A
39 psychotic disorder 10.1 DRD2 DRD3 HTR2A
40 obsessive-compulsive disorder 10.1 DRD2 DRD3 HTR2A
41 autism 10.1
42 myoclonus 10.1
43 epileptic encephalopathy, early infantile, 9 10.1 CDKL5 MECP2
44 apnea, obstructive sleep 10.1
45 multiple sclerosis 10.1
46 restless legs syndrome 10.1
47 visual epilepsy 10.1 CDKL5 FRRS1L MECP2
48 bipolar disorder 10.0 DRD2 DRD3 HTR2A
49 alcohol dependence 10.0 DRD2 DRD3 HTR2A
50 seizure disorder 10.0 CDKL5 MECP2

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism
Sources

Symptoms & Phenotypes for Bruxism

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UMLS symptoms related to Bruxism:


excessive daytime somnolence, snoring, sleep disturbances, sleeplessness, mental and behavioral signs and symptoms, toothache, teeth chattering

MGI Mouse Phenotypes related to Bruxism:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 CDKL5 DRD2 DRD3 DRD5 FRRS1L HTR2A
Sources

Drugs & Therapeutics for Bruxism

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Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 51-84-3 187
2
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4 Cholinergic Agents Phase 4,Phase 2,Phase 1,Not Applicable
5 Botulinum Toxins, Type A Phase 4,Phase 2,Phase 1,Not Applicable
6 abobotulinumtoxinA Phase 4,Phase 2,Phase 1,Not Applicable
7 Acetylcholine Release Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
9 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
10 Neuromuscular Agents Phase 4,Phase 2,Phase 1,Not Applicable
11 Botulinum Toxins Phase 4,Phase 2,Phase 1,Not Applicable
12 Anti-Anxiety Agents Phase 4,Not Applicable
13 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
14 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
15 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
16 Serotonin Uptake Inhibitors Phase 4,Phase 2
17 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
18 Antidepressive Agents Phase 4,Phase 2,Not Applicable
19 Antidepressive Agents, Second-Generation Phase 4
20 Serotonin Agents Phase 4,Phase 2
21 Anesthetics Phase 4
22 Anesthetics, Local Phase 4
23 Sodium Channel Blockers Phase 4
24 Diuretics, Potassium Sparing Phase 4
25 Anti-Arrhythmia Agents Phase 4
26
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
27
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 69-72-7 338
28 Poke Phase 3
29 Lemon Balm Phase 3
30
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable 22916-47-8 4189
31
Hydrocortisone acetate Approved, Vet_approved Phase 2,Early Phase 1 50-03-3
32
Hydrocortisone Approved, Vet_approved Phase 2,Early Phase 1 50-23-7 5754
33
Dopamine Approved Phase 2,Not Applicable 62-31-7, 51-61-6 681
34
Norepinephrine Approved Phase 2 51-41-2 439260
35 Anti-Infective Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
36 Keratolytic Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
37 Antifungal Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
38 Dermatologic Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
39 Hydrocortisone hemisuccinate Phase 2,Early Phase 1
40 Hydrocortisone 17-butyrate 21-propionate Phase 2,Early Phase 1
41 Pharmaceutical Solutions Phase 2,Not Applicable
42 Sympathomimetics Phase 2,Not Applicable
43 Quetiapine Fumarate Phase 2 111974-72-2
44 Adrenergic alpha-Agonists Phase 2
45 Adrenergic Agonists Phase 2
46 Antipsychotic Agents Phase 2
47 Adrenergic Agents Phase 2,Not Applicable
48 Autonomic Agents Phase 2,Not Applicable
49 Vasoconstrictor Agents Phase 2
50 Serotonin Receptor Agonists Phase 2

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
2 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
3 Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient Recruiting NCT03522207 Phase 4 Trazodone;Placebos;Trazodone;placebos
4 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
5 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Unknown status NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
6 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
7 The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders Completed NCT03371888 Phase 2, Phase 3
8 The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals Unknown status NCT02332525 Phase 1, Phase 2
9 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
10 Occlusal Adjustment as Treatment for Chronic Orofacial Pain Completed NCT00899717 Phase 1, Phase 2
11 Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study Recruiting NCT03827122 Phase 2 onabotulinumtoxinA
12 Evaluation of the Effectiveness of Infrared LED Photobiomodulation in Children With Sleep Bruxism Recruiting NCT03710174 Phase 2
13 A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy Active, not recruiting NCT03321526 Phase 2 JNJ-42847922;Placebo Matching to JNJ-42847922;Quetiapine XR;Placebo Matching to Quetiapine XR;Selective Serotonin Reuptake Inhibitor (SSRI);Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
14 A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea Recruiting NCT03796026 Phase 1 Seltorexant 40 mg;Placebo
15 Botox for Treatment of TMJ Disorder With Bruxism Withdrawn NCT02202070 Phase 1 onabotulinumtoxinA
16 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Unknown status NCT02757261 Early Phase 1
17 Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism Unknown status NCT01778881 Not Applicable
18 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
19 Prevalence of Bruxism in a Group of Preschool Egyptian Children Unknown status NCT03006133
20 TMJ NextGen Pilot Study to Treat Subjects With Bruxism Unknown status NCT02446288 Not Applicable
21 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance Unknown status NCT02235220 Not Applicable
22 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
23 The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism Completed NCT03499665 Not Applicable
24 Enterobius Vermicularis and Bruxism in Children Completed NCT03833505
25 Sleep Architecture and Factors Associated With Definitive Diagnosis of Sleep Bruxism Completed NCT03825237
26 Respiratory Problems and Caries in Children With Bruxism Completed NCT01463826
27 Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880 Not Applicable
28 Floral Remedies for Sleep-bruxism Patients Completed NCT03112954 Not Applicable Buccal-relaxant formula;Placebo
29 Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism Completed NCT01255878 Not Applicable Gabapentine
30 TMJ NextGeneration(TM) Feasibility Study Completed NCT02257320 Not Applicable
31 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
32 Efficacy of Physiotherapy in Patients With Bruxism. Completed NCT03555201 Not Applicable
33 Nocturnal Mouth Guards, SOVA vs. Standard Acrylic Orthotic; Phase IV Completed NCT02340663 Not Applicable
34 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182 Not Applicable
35 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389 Not Applicable
36 Occlusal Splints or Botulinum Toxin? Completed NCT03891121 Not Applicable Botulinum toxin type A
37 Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices Completed NCT02148510 Not Applicable
38 Impact of an Intensive Multimodal Educative Program on Behavioral Disorders of Patients With Profound Multiple Disabilities and on the Quality of Life and Feelings of Caregivers Completed NCT02510846 Not Applicable
39 Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma Completed NCT03621891
40 Conservative Treatment of Patients With Temporomandibular Disorders Completed NCT01021306 Not Applicable
41 All-ceramic Crowns in Patients With Sleep Bruxism Recruiting NCT03039985 Not Applicable
42 Clinical Efficacy of Crowns Fabricated Using LuxaCrown Recruiting NCT03160950 Not Applicable
43 A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA Recruiting NCT03655990
44 Temporomandibular Dysfunction in Patients With Tinnitus: Assessment and Treatment Recruiting NCT03209297 Not Applicable
45 Clinical Performance of a Glass Hybrid Restorative in NCCL's of Patients With Bruxism Active, not recruiting NCT03713827 Not Applicable
46 Sleep Bruxism and (Peri-)Implant Complications Active, not recruiting NCT02410681
47 Evaluation of Selected Disorders With Sleep Bruxism Enrolling by invitation NCT03083405 Clonidine;Buspirone
48 OstiSense Biosensor in Bruxism Reduction - A Clinical Study Not yet recruiting NCT03749928 Not Applicable
49 Validation of a Diagnostic Method for Quantification of Sleep Bruxism Not yet recruiting NCT03325920 Not Applicable
50 Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility Study Not yet recruiting NCT03363204 Not Applicable

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Sources

Genetic Tests for Bruxism

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Sources

Anatomical Context for Bruxism

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MalaCards organs/tissues related to Bruxism:

42
Brain, Bone, Eye, Heart, Testes, Tongue, Kidney
Sources

Publications for Bruxism

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Articles related to Bruxism:

(show top 50) (show all 1053)
# Title Authors Year
1
Association between sleep bruxism and anxiety symptoms in adults: a systematic review. ( 30805947 )
2019
2
Evidence-based dentistry or meta-analysis illness? A commentary on current publishing trends in the field of temporomandibular disorders and bruxism. ( 30203622 )
2019
3
Association between self-reported bruxism and anger and frustration. ( 30298526 )
2019
4
Comparison of kinesio taping and occlusal splint in the management of myofascial pain in patients with sleep bruxism. ( 30475753 )
2019
5
STXBP1 encephalopathy is associated with awake bruxism. ( 30654231 )
2019
6
Effects of a contingent vibratory stimulus delivered by an intra-oral device on sleep bruxism: a pilot study. ( 30685853 )
2019
7
Pain perception and functional/occlusal parameters in sleep bruxism subjects following a therapeutic intervention. ( 30696443 )
2019
8
Impact of sleep bruxism on training-induced cortical plasticity. ( 30704929 )
2019
9
Revisited relationships between probable sleep bruxism and clinical muscle symptoms. ( 30716450 )
2019
10
Occlusion time analysis in military pilots affected by bruxism. ( 30723236 )
2019
11
Seasonality of bruxism: evidence from Google Trends. ( 30790220 )
2019
12
Fulminant thymomatous AMPAR-antibody limbic encephalitis with hypertonic coma, bruxism, an isoelectric electroencephalogram and temporal cortical atrophy, with recovery. ( 30796080 )
2019
13
Knowledge of parents/caregivers about the sleep bruxism of their children from all five Brazilian regions: a multicenter study. ( 30805966 )
2019
14
Treatments of sleep bruxism in children: A systematic review and meta-analysis. ( 30806589 )
2019
15
The efficacy of low and moderate dosage of diazepam on sleep bruxism in children: A randomized placebo-controlled clinical trial. ( 30815021 )
2019
16
A window to consolidate the "functional hypothesis of bruxism" through cardiovascular autonomic link. ( 30825349 )
2019
17
Response to Letter to the Editor "A window to consolidate the "functional hypothesis of bruxism" through cardiovascular autonomic link". ( 30828901 )
2019
18
The prevalence of awake bruxism and sleep bruxism in the Dutch adult population. ( 30830687 )
2019
19
Homeopathic medicine of Melissa officinalis combined or not with Phytolacca decandra in the treatment of possible sleep bruxism in children: A crossover randomized triple-blinded controlled clinical trial. ( 30831467 )
2019
20
Long-term follow-up of a patient with venlafaxine-induced diurnal bruxism treated with an occlusal splint: A case report. ( 30842964 )
2019
21
Common mental disorders and bruxism in adults: A Birth Cohort study. ( 30851344 )
2019
22
Ecological Momentary Assessment and Intervention Principles for the Study of Awake Bruxism Behaviors, Part 1: General Principles and Preliminary Data on Healthy Young Italian Adults. ( 30881335 )
2019
23
Association between bruxism and temporomandibular disorders in children: a systematic review and meta-analysis. ( 30888712 )
2019
24
Ecological Momentary Assessment and Intervention Principles for the Study of Awake Bruxism Behaviors, Part 2: Development of a Smartphone Application for a Multicenter Investigation and Chronological Translation for the Polish Version. ( 30890999 )
2019
25
Complete rehabilitation of patients with bruxism by veneered and non-veneered zirconia restorations with an increased vertical dimension of occlusion: an observational case-series study. ( 30904358 )
2019
26
Self-reported awake bruxism and chronotype profile: a multicenter study on Brazilian, Portuguese and Italian dental students. ( 30907703 )
2019
27
Sleep Bruxism and Occurrence of Temporomandibular Disorders-Related Pain: A Polysomnographic Study. ( 30915015 )
2019
28
Bruxism Unconscious Oral Habit in Everyday Life. ( 30962854 )
2019
29
The prevalence of bruxism and related factors in patients with multiple sclerosis: a comparative study. ( 30970131 )
2019
30
Bruxism: An umbrella review of systematic reviews. ( 30993738 )
2019
31
Effect of experimental temporomandibular disorder pain on sleep bruxism: a pilot study in males. ( 31028465 )
2019
32
Current Methods of Bruxism Diagnosis: A Short Communication. ( 31034542 )
2019
33
Sleep bruxism: population based study in people with 18 years or more in the city of Rio Grande, Brazil. ( 31038571 )
2019
34
A systematic review of botulinum toxin in the management of patients with temporomandibular disorders and bruxism. ( 31076698 )
2019
35
Are YouTube Videos Useful for Patients Interested in Botulinum Toxin for Bruxism? ( 31077674 )
2019
36
Orofacial pain experience among symphony orchestra musicians in Finland is associated with reported stress, sleep bruxism, and disrupted sleep - independent of the instrument group. ( 31081155 )
2019
37
Validity of single-channel masseteric electromyography by using an ultraminiature wearable electromyographic device for diagnosis of sleep bruxism. ( 31085074 )
2019
38
To what extent is bruxism associated with musculoskeletal signs and symptoms? A systematic review. ( 31090938 )
2019
39
Awake and Sleep Bruxism Among Israeli Adolescents. ( 31105645 )
2019
40
Fracture Resistance of Monolithic Zirconia Crowns in Implant Prostheses in Patients with Bruxism. ( 31108872 )
2019
41
Association of sleep bruxism with oral health-related quality of life and sleep quality. ( 29589157 )
2019
42
The effectiveness of an occlusal disclosure sheet to diagnose sleep bruxism: A pilot study. ( 29179652 )
2019
43
Painful temporomandibular disorder, sleep bruxism, anxiety symptoms and subjective sleep quality among military firefighters with frequent episodic tension-type headache. A controlled study. ( 29972421 )
2018
44
Grinding to a halt: Stimulation of the trigeminal cardiac reflex from severe bruxism. ( 30112280 )
2018
45
Effect of sleep bruxism duration on perceived sleep quality in middle-aged subjects. ( 30113747 )
2018
46
A preliminary study on potential association between psychopathological status and rhythmic masticatory muscle activity of young patients with sleep bruxism in Tianjin China. ( 30114553 )
2018
47
The Co-Occurrence of Sexsomnia, Sleep Bruxism and Other Sleep Disorders. ( 30142877 )
2018
48
Ultrasonographic evaluation of jaw elevator muscles in young adults with bruxism and with and without attrition-type tooth wear: A pilot study. ( 30153104 )
2018
49
Aesthetic Rehabilitation in Teeth with Wear from Bruxism and Acid Erosion. ( 30159094 )
2018
50
Sleep Bruxism and Pain. ( 30189988 )
2018
Sources

Variations for Bruxism

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ClinVar genetic disease variations for Bruxism:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MECP2 NM_004992.3(MECP2): c.377+1G> T single nucleotide variant Pathogenic rs267608463 GRCh38 Chromosome X, 154032206: 154032206
2 MECP2 NM_004992.3(MECP2): c.377+1G> T single nucleotide variant Pathogenic rs267608463 GRCh37 Chromosome X, 153297657: 153297657
3 CDKL5 NM_003159.2(CDKL5): c.622C> T (p.Gln208Ter) single nucleotide variant Pathogenic rs587783405 GRCh37 Chromosome X, 18606141: 18606141
4 CDKL5 NM_003159.2(CDKL5): c.622C> T (p.Gln208Ter) single nucleotide variant Pathogenic rs587783405 GRCh38 Chromosome X, 18588021: 18588021
Sources

Expression for Bruxism

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Search GEO for disease gene expression data for Bruxism.
Sources

Pathways for Bruxism

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Pathways related to Bruxism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Monoamine GPCRs 1
Show member pathways
 11.3 DRD2 DRD3 DRD5 HTR2A
2
DARPP-32 Phosphorylation 66
10.14 DRD2 DRD3 DRD5
Sources

GO Terms for Bruxism

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Cellular components related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 9.26 CDKL5 DRD2 DRD3 HTR2A
2 non-motile cilium GO:0097730 9.16 DRD2 DRD5
3 dopaminergic synapse GO:0098691 8.62 DRD2 DRD3

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.75 DRD3 DRD5 HTR2A
2 visual learning GO:0008542 9.67 DRD2 DRD3 MECP2
3 positive regulation of cytokinesis GO:0032467 9.65 DRD2 DRD3
4 long-term memory GO:0007616 9.65 DRD2 MECP2
5 regulation of dopamine secretion GO:0014059 9.65 DRD3 HTR2A
6 associative learning GO:0008306 9.64 DRD2 DRD5
7 response to morphine GO:0043278 9.64 DRD2 DRD3
8 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD3
9 temperature homeostasis GO:0001659 9.63 DRD2 HTR2A
10 response to cocaine GO:0042220 9.63 DRD2 DRD3 DRD5
11 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.62 DRD2 DRD3
12 dopamine receptor signaling pathway GO:0007212 9.62 DRD2 DRD3
13 negative regulation of protein secretion GO:0050709 9.61 DRD2 DRD3
14 startle response GO:0001964 9.61 DRD2 MECP2
15 dopamine metabolic process GO:0042417 9.6 DRD2 DRD3
16 prepulse inhibition GO:0060134 9.59 DRD2 DRD3
17 positive regulation of renal sodium excretion GO:0035815 9.58 DRD2 DRD3
18 G protein-coupled receptor internalization GO:0002031 9.57 DRD2 DRD3
19 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.56 DRD3 DRD5
20 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.55 DRD2 DRD3
21 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.54 DRD2 HTR2A
22 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.52 DRD2 DRD5
23 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.51 DRD2 DRD3
24 response to amphetamine GO:0001975 9.5 DRD2 DRD3 DRD5
25 negative regulation of dopamine receptor signaling pathway GO:0060160 9.48 DRD2 DRD3
26 acid secretion GO:0046717 9.43 DRD2 DRD3
27 regulation of locomotion involved in locomotory behavior GO:0090325 9.4 DRD2 DRD3
28 response to histamine GO:0034776 9.37 DRD2 DRD3
29 negative regulation of blood pressure GO:0045776 9.33 DRD2 DRD3 DRD5
30 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 9.26 DRD2 MECP2
31 behavioral response to cocaine GO:0048148 9.13 DRD2 DRD3 HTR2A
32 synaptic transmission, dopaminergic GO:0001963 8.8 DRD2 DRD3 DRD5

Molecular functions related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 9.37 DRD5 HTR2A
2 drug binding GO:0008144 9.33 DRD2 DRD3 HTR2A
3 adrenergic receptor activity GO:0004935 9.32 DRD2 DRD3
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.26 DRD2 DRD3
5 dopamine binding GO:0035240 9.13 DRD2 DRD3 DRD5
6 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD2 DRD3 DRD5
Sources

Sources for Bruxism

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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