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MCID: BRX001
MIFTS: 49

Bruxism

Categories: Mental diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bruxism

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MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 55 6 44 15 72
Sleep Bruxism 44 72
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 72
Grinding Teeth 12
Teeth Grinding 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2846
ICD9CM 35 327.53
NCIt 50 C73511
SNOMED-CT 68 90207007
ICD10 33 F45.8 G47.63
UMLS 72 C0006325 C0393774 C0751771
Sources

Summaries for Bruxism

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Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to tic disorder and generalized anxiety disorder, and has symptoms including excessive daytime somnolence, snoring and sleep disturbances. An important gene associated with Bruxism is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Monoamine GPCRs. The drugs carbamide peroxide and Trazodone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and tongue, and related phenotype is behavior/neurological.

Wikipedia : 75 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

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Related Diseases for Bruxism

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Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 tic disorder 30.8 HTR2A DRD5 DRD2
2 generalized anxiety disorder 30.6 SLC6A4 HTR2A DRD2
3 visual epilepsy 30.6 MECP2 FRRS1L CDKL5
4 social phobia 30.4 SLC6A4 DRD2
5 conduct disorder 30.3 SLC6A4 DRD5 DRD2
6 encephalopathy 30.2 MECP2 FRRS1L CDKL5
7 migraine with or without aura 1 30.2 SLC6A4 HTR2A DRD5 DRD3 DRD2
8 major depressive disorder 30.2 SLC6A4 HTR2A DRD3 DRD2
9 oppositional defiant disorder 30.1 SLC6A4 DRD2
10 post-traumatic stress disorder 30.1 SLC6A4 HTR2A DRD2
11 pervasive developmental disorder 30.1 SLC6A4 MECP2 CDKL5
12 tobacco addiction 30.1 SLC6A4 HTR2A DRD2
13 autism 30.0 SLC6A4 MECP2 HTR2A CDKL5
14 obsessive-compulsive disorder 29.9 SLC6A4 HTR2A DRD3 DRD2
15 substance abuse 29.7 SLC6A4 DRD5 DRD3 DRD2
16 fibromyalgia 29.7 SLC6A4 HTR2A
17 attention deficit-hyperactivity disorder 29.7 SLC6A4 MECP2 HTR2A DRD5 DRD3 DRD2
18 bipolar disorder 29.7 SLC6A4 HTR2A DRD3 DRD2
19 alcohol dependence 29.7 SLC6A4 HTR2A DRD3 DRD2
20 parkinson disease, late-onset 29.6 SLC6A4 HTR2A DRD3 DRD2
21 disease of mental health 29.4 SLC6A4 MECP2 HTR2A DRD3 DRD2
22 parasomnia, sleep bruxism type 12.6
23 neurodegeneration with brain iron accumulation 5 11.2
24 oromandibular dystonia 11.2
25 cdkl5 deficiency disorder 11.2
26 sleep disorder 10.7
27 early-onset schizophrenia 10.6 HTR2A DRD2
28 substance-induced psychosis 10.6 HTR2A DRD2
29 headache 10.6
30 gait apraxia 10.5 MECP2 CDKL5
31 sleep apnea 10.5
32 delusional disorder 10.5 DRD3 DRD2
33 infantile hypotonia 10.5 UNC80 MECP2
34 polysubstance abuse 10.5 DRD3 DRD2
35 impulse control disorder 10.5 DRD3 DRD2
36 drug psychosis 10.4 HTR2A DRD2
37 anxiety 10.4
38 movement disease 10.4
39 dystonia 10.4
40 drug-induced mental disorder 10.4 HTR2A DRD2
41 tardive dyskinesia 10.4 HTR2A DRD3 DRD2
42 gastroesophageal reflux 10.4
43 alcohol-induced mental disorder 10.4 SLC6A4 DRD2
44 atypical depressive disorder 10.4 SLC6A4 HTR2A
45 aicardi syndrome 10.3 IQSEC2 CDKL5
46 psychosexual disorder 10.3 SLC6A4 HTR2A
47 depression 10.3
48 myoclonus 10.3
49 muscle hypertrophy 10.3
50 chronic pain 10.3

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism
Sources

Symptoms & Phenotypes for Bruxism

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UMLS symptoms related to Bruxism:


excessive daytime somnolence, snoring, sleep disturbances, sleeplessness, mental and behavioral signs and symptoms, toothache, teeth chattering

MGI Mouse Phenotypes related to Bruxism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.28 CDKL5 DRD2 DRD3 DRD5 FRRS1L HTR2A
Sources

Drugs & Therapeutics for Bruxism

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Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
carbamide peroxide Approved Phase 4 124-43-6
2
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
3
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5 Anti-Infective Agents Phase 4
6 Anti-Infective Agents, Local Phase 4
7 Tranquilizing Agents Phase 4
8 Antidepressive Agents Phase 4
9 Psychotropic Drugs Phase 4
10 Anti-Anxiety Agents Phase 4
11 Serotonin Agents Phase 4
12 Serotonin Uptake Inhibitors Phase 4
13 Antidepressive Agents, Second-Generation Phase 4
14 Central Nervous System Depressants Phase 4
15 Neurotransmitter Agents Phase 4
16 Peripheral Nervous System Agents Phase 4
17 Cholinergic Agents Phase 4
18 Acetylcholine Release Inhibitors Phase 4
19 Botulinum Toxins Phase 4
20 Anesthetics, Local Phase 4
21 Sodium Channel Blockers Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Anesthetics Phase 4
24 Anti-Arrhythmia Agents Phase 4
25
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
26
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
27 Lemon Balm Phase 3
28 Poke Phase 3
29
Ethanol Approved Phase 2 64-17-5 702
30
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
31
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
32
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
33 abobotulinumtoxinA Phase 2
34 Neuromuscular Agents Phase 2
35 Botulinum Toxins, Type A Phase 2
36 insulin Phase 2
37 Insulin, Globin Zinc Phase 2
38 Antifungal Agents Phase 1, Phase 2
39 Keratolytic Agents Phase 1, Phase 2
40 Dermatologic Agents Phase 1, Phase 2
41 Hydrocortisone 17-butyrate 21-propionate Phase 2
42 Hydrocortisone hemisuccinate Phase 2
43 Pharmaceutical Solutions Phase 2
44
Gabapentin Approved, Investigational 60142-96-3 3446
45
Dinoprostone Approved 363-24-6 5280360
46
Etoricoxib Approved, Investigational 202409-33-4 123619
47
Lithium carbonate Approved 554-13-2
48
Dopamine Approved 51-61-6, 62-31-7 681
49
Methamphetamine Approved, Illicit 537-46-2 10836
50
Clonidine Approved 4205-90-7 2803

Interventional clinical trials:

(show top 50) (show all 73)
# Name Status NCT ID Phase Drugs
1 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism by Different Injection Sites Evaluated by Polysomnography Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
2 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
3 "Evaluation of the Effectiveness and Longevity Post Whitening Carbamide Peroxide 10% in Smokers and Nonsmokers. Double-blind Multicenter Clinical Trial. " Completed NCT02017873 Phase 4 Peroxide Carbamide 10% - Dental bleaching treatment
4 Stabilisation de la qualité du Sommeil Chez le Sujet en Douleurs Orofaciales Chroniques - étude expérimentale en chassé croisé : Trazodone/ Placebo Recruiting NCT03522207 Phase 4 Trazodone;Placebos;Trazodone;placebos
5 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
6 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism: a Controlled and Randomized Clinical Trial Unknown status NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
7 Resin Based Composite Occlusal Restoration Postoperative Hypersensitivity: Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
8 The Platelet -Rich Plasma in the Therapy of Temporomandibular Disorders Completed NCT03371888 Phase 2, Phase 3
9 The Influence of Oral Vibrational Stimulation on Brain Activity and Cognitive Function of Elderly Individuals With Mild Cognitive Impairment Unknown status NCT02332525 Phase 1, Phase 2
10 Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study Unknown status NCT02810015 Phase 2 Botulinum Toxin Type A
11 AWARNESS THROUGH MOVEMENT PHYSIOTERAPEUTIC TECHNIQUE INCREASED THE AIRWAY DIMENSIONS OF BRUXIST CHILDREN: A SINGLE BLIND RANDOMIZED CLINICAL TRIAL. Completed NCT01178229 Phase 1, Phase 2
12 Basis for an Etiological Diagnosis and Treatment of the Chronic TMD-pain: RCT Study Completed NCT00899717 Phase 1, Phase 2
13 Evaluation of the Effectiveness of Infrared LED Photobiomodulation in Children With Sleep Bruxism: Study Protocol for Randomized Clinical Trial. Recruiting NCT03710174 Phase 2
14 Botulinum Toxin A Injectable Solution in the Management of Bruxism Recruiting NCT03827122 Phase 2 onabotulinumtoxinA
15 Phase 1 Study of Role of Botox in Myofascial Temporomandibular Disorder Withdrawn NCT02202070 Phase 1 onabotulinumtoxinA
16 A Pilot Study of the TMJ NextGeneration Compared to the DSG Relaxer for Reduction in Nocturnal Bruxism Episodes in Subjects Diagnosed With Sleep Bruxism Unknown status NCT02446288
17 Effectiveness of Physical Therapy Interventions, Relative to Dental Treatment in Individuals With Bruxism: a Randomized Clinical Trial Unknown status NCT01778881
18 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Before and After Laser Use of Low Power in Acupoints- Controlled Clinical Trial Unknown status NCT02757261 Early Phase 1
19 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
20 Prevalence of Bruxism in a Group of Preschool Egyptian Children Unknown status NCT03006133
21 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance With Composite Resin Fillings in Patients With Bruxism. Unknown status NCT02235220
22 The Prevalence and Risk Factors for Patients With Peri-implant Disease：a Retrospective Study Unknown status NCT02662361
23 Analysis of the Prevalence and Characteristics of Co-Morbid Sleep and Headache Disorders in Patients Being Evaluated at the WRAMC Sleep Disorders Laboratory, and the Efficacy of CPAP Treatment on Headache Burden in Obstructive Sleep Apnea Patients With a Co-Morbid Headache Disorder Unknown status NCT00520156
24 Clinical Condition and Sleep Quality Factors Associated With Sleep Bruxism in Adults: a Study Using Polysomnography. Completed NCT04015349
25 Sleep Architecture and Factors Associated With Definitive Diagnosis of Sleep Bruxism: a Case-control Study Completed NCT03825237
26 The Efficacy of Gabapentine and Splint Therapy in Bruxers: a Randomized Clinical Trial Completed NCT01255878 Gabapentine
27 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389
28 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182
29 Evaluation of Relationship Between Enterobius Vermicularis Infection and Bruxism in Children Completed NCT03833505
30 Associations Between Sleep Bruxism and (Peri-)Implant Complications: a Follow-up Study Completed NCT02410681
31 The Treatment of Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880
32 Floral Remedies for Sleep Bruxism Patients: A Randomized Trial for Attenuating Temporal Cephalic Pain Completed NCT03112954 Buccal-relaxant formula;Placebo
33 Assessment The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism Completed NCT03499665
34 A Feasibility Study of the Bruxoffâ„¢ Device to Assess EMG Activity in Subjects Diagnosed With Sleep Bruxism Using TMJ NextGeneration(TM) Completed NCT02257320
35 Preliminary Phase IV Trial Comparing the SOVA Night Guard With the Clinical Standard Acrylic Orthotic Completed NCT02340663
36 Association Between Respiratory Problem and Dental Caries in Children With Bruxism Completed NCT01463826
37 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
38 Oral Appliance in the Treatment of Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing the Efficacy of Two Devices Completed NCT02148510
39 Efficacy of a Physiotherapy Protocol Based on Manual Therapy in Patients With Bruxism. Completed NCT03555201
40 Feasibility Study Regarding the Implantation and Use of Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders (Either Obsessive-compulsive Disorder or Major Depression) Completed NCT02685280
41 The Effects of Mindfulness and RelaxationTraining for Insomnia (MRTI) on Postmenopausal Women: a Randomized Clinical Trial. Completed NCT01593436
42 Which One is Effective in Treatment of Bruxism? Occlusal Splints or Botulinum Toxin Completed NCT03891121 Botulinum toxin type A
43 Postoperative Evaluation of the Intraoral Technique of Buccal Fat Pad Removal Completed NCT03974373
44 COMPARISION OF DIFFERENT TREATMENT METHODS OF PERI-IMPLANTITIS Completed NCT03241953
45 Analysis of Clinical Wear Patterns of Tooth Enamel and Ceramic Restorations as a Function of Particle Size, Inter-Particle Spacing and Fracture Toughness of Ceramic Crystals Completed NCT00223405
46 The Effect of Different Dental Implant Surface Characteristics on Bone Immunological Biomarkers and Microbiological Parameters: A Randomized Clinical Study Completed NCT03693196
47 Effectiveness Specific Manual Therapy in a Multimodal Physical Therapy Treatment in Patients With Tinnitus and Temporomandibular Joint Disorder. Completed NCT02850055
48 Accuracy of Computer-assisted Template-based Implant Placement Using CAD/CAM Stereolithographic Surgical Templates With or Without Metallic Sleeves: a Randomized Controlled Trial Completed NCT03641365
49 Effect of Preoperative Use of an Anti-inflammatory on Tooth Sensitivity Caused by In-office Bleaching: A Randomized, Double-blind Clinical Trial Completed NCT01300780 Etoricoxib
50 Effect on Oral Health, Phycosocial Impact and Esthetics Perception of Bleaching Teeth Completed NCT02605239 Bleaching teeth

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Sources

Genetic Tests for Bruxism

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Sources

Anatomical Context for Bruxism

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MalaCards organs/tissues related to Bruxism:

41
Brain, Bone, Tongue, Eye, Heart, Testes, Thyroid
Sources

Publications for Bruxism

About this section

Articles related to Bruxism:

(show top 50) (show all 2243)
# Title Authors PMID Year
1
Stereotypies in Rett syndrome: analysis of 83 patients with and without detected MECP2 mutations. 9 38
17420401 2007
2
Double-blind, crossover, placebo-controlled trial of bromocriptine in patients with sleep bruxism. 9 38
11391125 2001
3
Oral and dental findings in emanuel syndrome. 38
30980693 2019
4
To what extent is bruxism associated with musculoskeletal signs and symptoms? A systematic review. 38
31090938 2019
5
Association between bruxism and temporomandibular disorders in children: A systematic review and meta-analysis. 38
30888712 2019
6
Does sleep bruxism affect masticatory muscles volume and occlusal force distribution in young subjects? A preliminary study. 38
29558863 2019
7
Poor sleep quality and prevalence of probable sleep bruxism in primary and mixed dentitions: a cross-sectional study. 38
30569316 2019
8
Oro-facial pain experience among symphony orchestra musicians in Finland is associated with reported stress, sleep bruxism and disrupted sleep-Independent of the instrument group. 38
31081155 2019
9
Masticatory function and oral stereognosis in bruxers. 38
29336237 2019
10
Smartphone-assisted monitoring of masticatory muscle activity in freely moving individuals. 38
30607622 2019
11
Consensus-based clinical guidelines for ambulatory electromyography and contingent electrical stimulation in sleep bruxism. 38
31430389 2019
12
A review and guide to drug-associated oral adverse effects-Dental, salivary and neurosensory reactions. Part 1. 38
31192500 2019
13
Associations between tooth wear and dental sleep disorders: A narrative overview. 38
31038764 2019
14
Investigation of the relationship between sleep disorders and xerostomia. 38
31372830 2019
15
Drug-induced bruxism. 38
31427840 2019
16
Clinical and intra-operative factors affecting the outcome of arthrocentesis in disc displacement without reduction: A retrospective study. 38
31044441 2019
17
Radiographic changes of trabecular bone density after loading of implant-supported complete dentures: A 3-year prospective study. 38
31373178 2019
18
Prevalence of non-carious cervical lesions among the general population of the Republic of Srpska, Bosnia and Herzegovina. 38
30730056 2019
19
[Assessment of different pain management methods for the treatment of claw lesions in Meat Merino ewes]. 38
31434114 2019
20
Efficacy of Biofeedback for Medical Conditions: an Evidence Map. 38
31414354 2019
21
[Present situation and future of occlusal splint in treatment of oral diseases]. 38
31378028 2019
22
The prevalence of posterior crossbite, deep bite, and sleep or awake bruxism in temporomandibular disorder (TMD) patients compared to a non-TMD population: A retrospective study. 38
31370774 2019
23
Polysomnographic scoring of sleep bruxism events is accurate even in the absence of video recording but unreliable with EMG-only setups. 38
31402440 2019
24
Risk factors for mandibular bone resorption in complete denture wearers. 38
31355766 2019
25
Treatment of Sleep Bruxism With a Single Daily Dose of Buspirone in a 7-Year-Old Boy. 38
31157634 2019
26
Reprint of "EEG: Characteristics of drug-induced seizures in rats, dogs and non-human primates". 38
31351950 2019
27
The bruxism construct: From cut-off points to a continuum spectrum. 38
31264730 2019
28
Efficacy of botulinum toxin in the treatment of bruxism: Systematic review. 38
31246937 2019
29
Bruxism: An umbrella review of systematic reviews. 38
30993738 2019
30
The prevalence of awake bruxism and sleep bruxism in the Dutch adult population. 38
30830687 2019
31
[Parkinson's disease, temporomandibular disorders and bruxism: A pilot study]. 38
31309935 2019
32
Impact of sleep bruxism on training-induced cortical plasticity. 38
30704929 2019
33
Twenty-four-month clinical performance of a glass hybrid restorative in non-carious cervical lesions of patients with bruxism: a split-mouth, randomized clinical trial. 38
31297658 2019
34
Do family functioning and mothers' and children's stress increase the odds of probable sleep bruxism among schoolchildren? A case control study. 38
31286259 2019
35
Association of bruxism and anxiety symptoms among military firefighters with frequent episodic tension type headache and temporomandibular disorders. 38
31365639 2019
36
Level of work stress and factors associated with bruxism in the military crew of the Peruvian Air Force. 38
31388233 2019
37
Knowledge of parents/caregivers about the sleep bruxism of their children from all five Brazilian regions: A multicenter study. 38
30805966 2019
38
Evaluation of tissue oxygen saturation of the masseter muscle during standardized teeth clenching. 38
31332831 2019
39
Absence of joint pain identifies high levels of sleep masticatory muscle activity in myofascial temporomandibular disorder. 38
31271666 2019
40
Are There Contraindications for Placing Dental Implants? 38
31097131 2019
41
Effect of Sustained Joint Loading on TMJ Disc Nutrient Environment. 38
31126205 2019
42
Oral manifestations of illicit drug use. 38
31309583 2019
43
The Presence of Physical Symptoms in Patients With Tinnitus: International Web-Based Survey. 38
31364603 2019
44
Seasonality of bruxism: evidence from Google Trends. 38
30790220 2019
45
Which Treatment Is Effective for Bruxism: Occlusal Splints or Botulinum Toxin? 38
31302066 2019
46
The Bruxoff Device as a Screening Method for Sleep Bruxism in Dental Practice. 38
31261634 2019
47
Geographical variation of parental-reported sleep bruxism among children: comparison between the Netherlands, Armenia and Indonesia. 38
30411782 2019
48
The Treatment of Hypersalivation in Rett Syndrome with Botulinum Toxin: Efficacy and Clinical Implications. 38
30617838 2019
49
Prevalence of Function-Dependent Temporomandibular Joint and Masticatory Muscle Pain, and Predictors of Temporomandibular Disorders among Patients with Lyme Disease. 38
31261623 2019
50
Oral habits and malocclusion in children resident in Ile-Ife Nigeria. 38
30506282 2019
Sources

Variations for Bruxism

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ClinVar genetic disease variations for Bruxism:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 MECP2 NM_004992.3(MECP2): c.377+1G> T single nucleotide variant Pathogenic rs267608463 X:153297657-153297657 X:154032206-154032206
2 CDKL5 NM_003159.2(CDKL5): c.622C> T (p.Gln208Ter) single nucleotide variant Pathogenic rs587783405 X:18606141-18606141 X:18588021-18588021
Sources

Expression for Bruxism

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Search GEO for disease gene expression data for Bruxism.
Sources

Pathways for Bruxism

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Pathways related to Bruxism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.54 SLC6A4 MECP2 HTR2A
2
Monoamine GPCRs 1
Show member pathways
 11.3 HTR2A DRD5 DRD3 DRD2
3
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.7 SLC6A4 HTR2A
4
DARPP-32 Phosphorylation 65
10.14 DRD5 DRD3 DRD2
Sources

GO Terms for Bruxism

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Cellular components related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 9.56 HTR2A DRD3 DRD2 CDKL5
2 non-motile cilium GO:0097730 9.32 DRD5 DRD2
3 dopaminergic synapse GO:0098691 9.16 DRD3 DRD2
4 integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 HTR2A DRD2
5 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 HTR2A DRD2

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.9 SLC6A4 HTR2A DRD3 DRD2
2 response to hypoxia GO:0001666 9.83 SLC6A4 MECP2 DRD2
3 cellular calcium ion homeostasis GO:0006874 9.77 HTR2A DRD5 DRD3
4 memory GO:0007613 9.73 SLC6A4 MECP2 HTR2A
5 social behavior GO:0035176 9.7 SLC6A4 MECP2 DRD3
6 long-term memory GO:0007616 9.67 MECP2 DRD2
7 visual learning GO:0008542 9.67 MECP2 DRD3 DRD2
8 regulation of dopamine secretion GO:0014059 9.66 HTR2A DRD3
9 response to morphine GO:0043278 9.66 DRD3 DRD2
10 associative learning GO:0008306 9.65 DRD5 DRD2
11 arachidonic acid secretion GO:0050482 9.65 DRD3 DRD2
12 temperature homeostasis GO:0001659 9.64 HTR2A DRD2
13 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.64 DRD3 DRD2
14 negative regulation of protein secretion GO:0050709 9.63 DRD3 DRD2
15 dopamine receptor signaling pathway GO:0007212 9.63 DRD3 DRD2
16 response to cocaine GO:0042220 9.63 DRD5 DRD3 DRD2
17 startle response GO:0001964 9.62 MECP2 DRD2
18 prepulse inhibition GO:0060134 9.62 DRD3 DRD2
19 dopamine metabolic process GO:0042417 9.61 DRD3 DRD2
20 positive regulation of renal sodium excretion GO:0035815 9.61 DRD3 DRD2
21 G protein-coupled receptor internalization GO:0002031 9.58 DRD3 DRD2
22 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.58 DRD3 DRD2
23 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.57 DRD5 DRD3
24 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.55 HTR2A DRD2
25 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.54 DRD5 DRD2
26 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.51 DRD3 DRD2
27 response to amphetamine GO:0001975 9.5 DRD5 DRD3 DRD2
28 negative regulation of dopamine receptor signaling pathway GO:0060160 9.48 DRD3 DRD2
29 response to histamine GO:0034776 9.43 DRD3 DRD2
30 negative regulation of blood pressure GO:0045776 9.43 DRD5 DRD3 DRD2
31 regulation of locomotion involved in locomotory behavior GO:0090325 9.4 DRD3 DRD2
32 acid secretion GO:0046717 9.37 DRD3 DRD2
33 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 9.16 MECP2 DRD2
34 behavioral response to cocaine GO:0048148 9.13 HTR2A DRD3 DRD2
35 synaptic transmission, dopaminergic GO:0001963 8.8 DRD5 DRD3 DRD2

Molecular functions related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 9.4 HTR2A DRD5
2 adrenergic receptor activity GO:0004935 9.37 DRD3 DRD2
3 drug binding GO:0008144 9.33 HTR2A DRD3 DRD2
4 serotonin binding GO:0051378 9.32 SLC6A4 HTR2A
5 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.26 DRD3 DRD2
6 dopamine binding GO:0035240 9.13 DRD5 DRD3 DRD2
7 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD5 DRD3 DRD2
Sources

Sources for Bruxism

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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