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MCID: BRX001
MIFTS: 53

Bruxism

Categories: Mental diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bruxism

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MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 29 55 6 44 15 73
Sleep Bruxism 44 73
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 73
Grinding Teeth 12
Teeth Grinding 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:2846
ICD10 33 F45.8 G47.63
ICD9CM 35 327.53
NCIt 50 C73511
SNOMED-CT 68 90207007
Sources

Summaries for Bruxism

About this section
Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to autism and attention deficit-hyperactivity disorder, and has symptoms including excessive daytime somnolence, sleep disturbances and snoring. An important gene associated with Bruxism is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Dopamine-DARPP32 Feedback onto cAMP Pathway and Monoamine GPCRs. The drugs Acetylcholine and Trazodone have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and endothelial, and related phenotype is behavior/neurological.

Wikipedia : 76 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

Sources

Related Diseases for Bruxism

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Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 autism 30.0 CDKL5 DRD2 DRD3 HTR2A MECP2
2 attention deficit-hyperactivity disorder 29.8 DRD2 DRD3 DRD5 HTR2A MECP2
3 encephalopathy 29.5 CDKL5 FRRS1L MECP2
4 parasomnia, sleep bruxism type 12.4
5 cdkl5 deficiency disorder 11.2
6 oromandibular dystonia 11.1
7 anxiety 10.4
8 sleep apnea 10.4
9 headache 10.4
10 gastroesophageal reflux 10.2
11 periodontal disease 10.2
12 depression 10.2
13 substance-induced psychosis 10.2 DRD2 HTR2A
14 early-onset schizophrenia 10.2 DRD2 HTR2A
15 gait apraxia 10.2 CDKL5 MECP2
16 brain injury 10.2
17 dystonia 10.2
18 polysubstance abuse 10.2 DRD2 DRD3
19 alcoholic psychosis 10.2 DRD2 HTR2A
20 periodic limb movement disorder 10.2 DRD2 HTR2A
21 delusional disorder 10.2 DRD2 DRD3
22 drug-induced mental disorder 10.2 DRD2 HTR2A
23 impulse control disorder 10.2 DRD2 DRD3
24 drug psychosis 10.2 DRD2 HTR2A
25 progressive multifocal leukoencephalopathy 10.2 HTR2A MECP2
26 cerebral palsy 10.2
27 epileptic encephalopathy, early infantile, 9 10.1 CDKL5 MECP2
28 infantile hypotonia 10.1 MECP2 UNC80
29 seizure disorder 10.1 CDKL5 MECP2
30 tic disorder 10.1 DRD2 DRD5 HTR2A
31 tardive dyskinesia 10.1 DRD2 DRD3 HTR2A
32 specific developmental disorder 10.1 CDKL5 DRD5 MECP2
33 pathological gambling 10.1 DRD2 DRD3 HTR2A
34 schizoaffective disorder 10.1 DRD2 DRD3 HTR2A
35 apnea, obstructive sleep 10.1
36 myoclonus 10.1
37 alcohol abuse 10.1 DRD2 DRD3 HTR2A
38 substance abuse 10.1 DRD2 DRD3 DRD5
39 migraine without aura 10.1 DRD2 DRD3
40 substance dependence 10.1 DRD2 DRD3 DRD5
41 mood disorder 10.1 DRD2 DRD3 HTR2A
42 psychotic disorder 10.1 DRD2 DRD3 HTR2A
43 obsessive-compulsive disorder 10.1 DRD2 DRD3 HTR2A
44 opiate dependence 10.1 DRD2 DRD3
45 restless legs syndrome 10.0
46 alcohol dependence 10.0 DRD2 DRD3 HTR2A
47 lymphedema, hereditary, ii 10.0 DRD5 HTR2A
48 major depressive disorder 10.0 DRD2 DRD3 HTR2A
49 disease of mental health 10.0 DRD2 DRD3 HTR2A MECP2
50 migraine with or without aura 1 10.0 DRD2 DRD3 DRD5 HTR2A

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism
Sources

Symptoms & Phenotypes for Bruxism

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UMLS symptoms related to Bruxism:


excessive daytime somnolence, sleep disturbances, snoring, sleeplessness, mental and behavioral signs and symptoms, toothache, teeth chattering

MGI Mouse Phenotypes related to Bruxism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.23 CDKL5 DRD2 DRD3 DRD5 FRRS1L HTR2A
Sources

Drugs & Therapeutics for Bruxism

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Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 4,Phase 1 51-84-3 187
2
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4 onabotulinumtoxinA Phase 4,Phase 1
5 Botulinum Toxins Phase 4,Phase 1
6 Botulinum Toxins, Type A Phase 4,Phase 1
7 Cholinergic Agents Phase 4,Phase 1
8 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1,Not Applicable
9 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
10 abobotulinumtoxinA Phase 4,Phase 1
11 Acetylcholine Release Inhibitors Phase 4,Phase 1
12 Neuromuscular Agents Phase 4,Phase 1
13 Tranquilizing Agents Phase 4,Phase 2,Not Applicable
14 Central Nervous System Depressants Phase 4,Phase 2,Not Applicable
15 Psychotropic Drugs Phase 4,Phase 2,Not Applicable
16 Anti-Anxiety Agents Phase 4,Not Applicable
17 Serotonin Uptake Inhibitors Phase 4,Phase 2
18 Antidepressive Agents Phase 4,Phase 2,Not Applicable
19 Serotonin Agents Phase 4,Phase 2
20 Neurotransmitter Uptake Inhibitors Phase 4,Phase 2,Not Applicable
21 Antidepressive Agents, Second-Generation Phase 4
22 Diuretics, Potassium Sparing Phase 4
23 Anesthetics, Local Phase 4
24 Anti-Arrhythmia Agents Phase 4
25 Anesthetics Phase 4
26 Sodium Channel Blockers Phase 4
27
Serotonin Investigational, Nutraceutical Phase 4,Phase 2 50-67-9 5202
28
Salicylic acid Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 69-72-7 338
29 Lemon Balm Phase 3
30 Poke Phase 3
31
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable 22916-47-8 4189
32
Hydrocortisone acetate Approved, Vet_approved Phase 2,Early Phase 1 50-03-3
33
Hydrocortisone Approved, Vet_approved Phase 2,Early Phase 1 50-23-7 5754
34
Dopamine Approved Phase 2,Not Applicable 51-61-6, 62-31-7 681
35
Norepinephrine Approved Phase 2 51-41-2 439260
36 Keratolytic Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
37 Anti-Infective Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
38 Antifungal Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
39 Dermatologic Agents Phase 1, Phase 2,Phase 2,Early Phase 1,Not Applicable
40 Cortisol succinate Phase 2,Early Phase 1
41 Hydrocortisone 17-butyrate 21-propionate Phase 2,Early Phase 1
42 Dopamine Agents Phase 2,Not Applicable
43 Sympathomimetics Phase 2,Not Applicable
44 Adrenergic Agents Phase 2,Not Applicable
45 Antipsychotic Agents Phase 2
46 Quetiapine Fumarate Phase 2 111974-72-2
47 Autonomic Agents Phase 2,Not Applicable
48 Adrenergic alpha-Agonists Phase 2
49 Serotonin and Noradrenaline Reuptake Inhibitors Phase 2
50 Adrenergic Agonists Phase 2

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
2 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
3 Accuracy and Efficacy of Trazodone (Desyrel) on Sleep Quality and Pain Management of TMD Patient Not yet recruiting NCT03522207 Phase 4 Trazodone;Placebos;Trazodone;placebos
4 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
5 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism Unknown status NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
6 Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
7 The Platelet-Rich Plasma in the Therapy of Temporomandibular Disorders Completed NCT03371888 Phase 2, Phase 3
8 The Influence of Oral Vibrational Stimulation on Cognitive Function of Elderly Individuals Unknown status NCT02332525 Phase 1, Phase 2
9 Physiotherapy on the Airway of Bruxist Children Completed NCT01178229 Phase 1, Phase 2
10 Occlusal Adjustment as Treatment for Chronic Orofacial Pain Completed NCT00899717 Phase 1, Phase 2
11 Evaluation of the Effectiveness of Infrared LED Photobiomodulation in Children With Sleep Bruxism Recruiting NCT03710174 Phase 2
12 A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy Recruiting NCT03321526 Phase 2 JNJ-42847922;Placebo Matching to JNJ-42847922;Quetiapine XR;Placebo Matching to Quetiapine XR;Selective Serotonin Reuptake Inhibitor (SSRI);Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)
13 A Study to Assess the Effect of Seltorexant Compared to Placebo on Respiration During Sleep in Adult Participants With Obstructive Sleep Apnea Recruiting NCT03796026 Phase 1 Seltorexant 40 mg;Placebo
14 Botox for Treatment of TMJ Disorder With Bruxism Withdrawn NCT02202070 Phase 1 onabotulinumtoxinA
15 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Unknown status NCT02757261 Early Phase 1
16 Physical Therapy Interventions Relative to Dental Treatment in Individuals With Bruxism Unknown status NCT01778881 Not Applicable
17 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
18 TMJ NextGen Pilot Study to Treat Subjects With Bruxism Unknown status NCT02446288 Not Applicable
19 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance Unknown status NCT02235220 Not Applicable
20 Analysis of the Prevalence and Characteristics of Concomitant Sleep and Headache Disorders, and the Efficacy of CPAP Treatment for Headache Among Those Patients Diagnosed With Obstructive Sleep Apnea Unknown status NCT00520156
21 The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism Completed NCT03499665 Not Applicable
22 Respiratory Problems and Caries in Children With Bruxism Completed NCT01463826
23 Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880 Not Applicable
24 Floral Remedies for Sleep-bruxism Patients Completed NCT03112954 Not Applicable Buccal-relaxant formula;Placebo
25 Comparative Evaluation of Gabapentine and Occlusal Splint in the Management of Sleep Bruxism Completed NCT01255878 Not Applicable Gabapentine
26 TMJ NextGeneration(TM) Feasibility Study Completed NCT02257320 Not Applicable
27 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
28 Efficacy of Physiotherapy in Patients With Bruxism. Completed NCT03555201 Not Applicable
29 Nocturnal Mouth Guards, SOVA vs. Standard Acrylic Orthotic; Phase IV Completed NCT02340663 Not Applicable
30 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182 Not Applicable
31 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389 Not Applicable
32 Oral Appliance in Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing Two Devices Completed NCT02148510 Not Applicable
33 Impact of an Intensive Multimodal Educative Program on Behavioral Disorders of Patients With Profound Multiple Disabilities and on the Quality of Life and Feelings of Caregivers Completed NCT02510846 Not Applicable
34 Alterations in Subgingival Microbiota and Hypoxia in Occlusal Trauma Completed NCT03621891
35 Conservative Treatment of Patients With Temporomandibular Disorders Completed NCT01021306 Not Applicable
36 Prevalence of Bruxism in a Group of Preschool Egyptian Children Recruiting NCT03006133
37 All-ceramic Crowns in Patients With Sleep Bruxism Recruiting NCT03039985 Not Applicable
38 Clinical Efficacy of Crowns Fabricated Using LuxaCrown Recruiting NCT03160950 Not Applicable
39 A Full-Arch Implant- Supported Prosthesis in the Upper and/or Lower Jaw-USA Recruiting NCT03655990
40 Temporomandibular Dysfunction in Patients With Tinnitus: Assessment and Treatment Recruiting NCT03209297 Not Applicable
41 Clinical Performance of a Glass Hybrid Restorative in NCCL's of Patients With Bruxism Active, not recruiting NCT03713827 Not Applicable
42 Sleep Bruxism and (Peri-)Implant Complications Active, not recruiting NCT02410681
43 Evaluation of Selected Disorders With Sleep Bruxism Enrolling by invitation NCT03083405 Clonidine;Buspirone
44 OstiSense Biosensor in Bruxism Reduction - A Clinical Study Not yet recruiting NCT03749928 Not Applicable
45 Validation of a Diagnostic Method for Quantification of Sleep Bruxism Not yet recruiting NCT03325920 Not Applicable
46 Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility Study Not yet recruiting NCT03363204 Not Applicable
47 Evaluation of Biofeedback Therapy Efficiency in Sleep Bruxism and Masticatory Muscles Pain Management Not yet recruiting NCT03421028 Not Applicable
48 Association Between Obstructive Sleep Apnea and Bruxism Not yet recruiting NCT03810248
49 Aspects Associated With Obstructive Sleep Apnea, Bruxism and Orofacial Pain Not yet recruiting NCT03766464
50 Aspects Associated With Sleep Quality Not yet recruiting NCT03766477

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Sources

Genetic Tests for Bruxism

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Genetic tests related to Bruxism:

# Genetic test Affiliating Genes
1 Bruxism 29
Sources

Anatomical Context for Bruxism

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MalaCards organs/tissues related to Bruxism:

41
Bone, Brain, Endothelial, Thyroid, Eye, Heart, Testes
Sources

Publications for Bruxism

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Articles related to Bruxism:

(show top 50) (show all 1003)
# Title Authors Year
1
Evaluation of the association of bruxism, psychosocial and sociodemographic factors in preschoolers. ( 29412225 )
2018
2
Bruxism- is botulinum toxin an effective treatment? ( 29930364 )
2018
3
Long-term variability of sleep bruxism and psychological stress in patients with jaw-muscle pain: Report of two longitudinal clinical cases. ( 29197103 )
2018
4
Prevalence of Sleep Bruxism in IBD Patients and Its Correlation to Other Dental Disorders and Quality of Life. ( 29721012 )
2018
5
Comparative Evaluation of Salivary Cortisol Levels in Bruxism Patients Before and After Using Soft Occlusal Splint: An <i>in vivo</i> Study. ( 29875558 )
2018
6
Fluoxetine-Induced Sleep Bruxism Rapidly Treated With Once-Nightly Dosing of Buspirone in a 6-Year-Old Girl. ( 29979192 )
2018
7
Possible sleep bruxism, circadian preference, and sleep-related characteristics and behaviors among dental students. ( 29741116 )
2018
8
Insufficient evidence about sleep bruxism being a risk factor for ceramic restoration failure. ( 29150017 )
2018
9
Painful temporomandibular disorder, sleep bruxism, anxiety symptoms and subjective sleep quality among military firefighters with frequent episodic tension-type headache. A controlled study. ( 29972421 )
2018
10
Onabotulinum toxin-A injections for sleep bruxism: A double-blind, placebo-controlled study. ( 29343468 )
2018
11
Evidence-Based Support for Sleep Bruxism Treatment Other Than Oral Appliances Remains Insufficient. ( 29747797 )
2018
12
SSRI-associated bruxism: A systematic review of published case reports. ( 29708207 )
2018
13
Bruxism and oral health-related quality of life among male inmates in a penal institution, Mysore: A cross-sectional study. ( 29900908 )
2018
14
Are there associations between sleep bruxism, chronic stress, and sleep quality? ( 29777735 )
2018
15
On Defining Bruxism. ( 29678021 )
2018
16
International consensus on the assessment of bruxism: Report of a work in progress. ( 29926505 )
2018
17
Can oral appliances reduce sleep bruxism?: Oral appliances for managing sleep bruxism in adults: a systematic review from 2007 to 2017. ( 29372702 )
2018
18
Association of sleep bruxism with oral health-related quality of life and sleep quality. ( 29589157 )
2018
19
Effects of clear aligners on sleep bruxism: randomized controlled trial. ( 29720327 )
2018
20
Changes in the temporomandibular joint disc and temporal and masseter muscles secondary to bruxism in Turkish patients. ( 29332113 )
2018
21
The risk factors related to bruxism in children: A systematic review and meta-analysis. ( 29149621 )
2018
22
The Effects of Sleeping With or Without Prostheses on Sleep Quality, Sleep Bruxism, and Signs of Obstructive Sleep Apnea Syndrome: A Pilot Study. ( 29723310 )
2018
23
Polysomnography-Detected Bruxism in Children is Associated With Somatic Complaints But Not Anxiety. ( 29198292 )
2018
24
Association between psychotropic medications and presence of sleep bruxism: A systematic review. ( 29663484 )
2018
25
Patents related to the treatment and diagnosis of bruxism. ( 29874935 )
2018
26
Relationship of self-reported sleep bruxism and awake bruxism with chronotype profiles in Italian dental students. ( 29376478 )
2018
27
The phenotype, psychotype and genotype of bruxism. ( 29599979 )
2018
28
Association of sleep bruxism with ceramic restoration failure: A systematic review and meta-analysis. ( 28967401 )
2018
29
Association of possible sleep bruxism in children with different chronotype profiles and sleep characteristics. ( 29363987 )
2018
30
Microstructural investigation of masticatory muscles: a pre- and post-treatment diffusion tensor imaging study in a bruxism case. ( 29470139 )
2018
31
A Painful Submandibular Mass in a Patient With Bruxism. ( 29470564 )
2018
32
Beating bruxism. ( 29521347 )
2018
33
Risk factors for bruxism ( 29533049 )
2018
34
Does sleep bruxism affect masticatory muscles volume and occlusal force distribution in young subjects? A preliminary study. ( 29558863 )
2018
35
Frequency of awake bruxism behaviours in the natural environment. A 7-day, multiple-point observation of real-time report in healthy young adults. ( 29574964 )
2018
36
DNA is hypomethylated in circadian manifestations of bruxism. ( 29575322 )
2018
37
Efficacy of biofeedback therapy on sleep bruxism: A systematic review and meta-analysis. ( 29577362 )
2018
38
Symptoms of temporomandibular disorder, self-reported bruxism, and the risk of implant failure: A retrospective analysis. ( 29985773 )
2018
39
Bruxism-Related Signs and Periodontal Disease: A Preliminary Study. ( 29988231 )
2018
40
Bruxism in dentists' families. ( 29989229 )
2018
41
Association between bruxism and symptomatic gastroesophageal reflux disease: A case-control study. ( 30017936 )
2018
42
Masticatory muscle stretching for the management of sleep bruxism: A randomised controlled trial. ( 30019357 )
2018
43
Parkinson's disease, temporomandibular disorders and bruxism: A pilot study. ( 30024048 )
2018
44
Effect of Physical Therapy in Bruxism Treatment: A Systematic Review. ( 30041736 )
2018
45
The hemodynamic effects of occlusal splint therapy on the masseter muscle of patients with myofascial pain accompanied by bruxism. ( 30048227 )
2018
46
Bruxism-induced parotitis: A retrospective case series analysis. ( 30048228 )
2018
47
Association between self-reported sleep bruxism and temporomandibular disorder in undergraduate students from Brazil. ( 30048229 )
2018
48
Impact of Temporomandibular Disorders and Sleep Bruxism on Oral Health-Related Quality of Life of Individuals With Complete Cleft Lip and Palate. ( 30074958 )
2018
49
Current Evidence About Relationships Among Prosthodontic Planning and Temporomandibular Disorders and/or Bruxism. ( 30077384 )
2018
50
Prevalence and associated factors to sleep bruxism in adolescents from Teresina, Piauí. ( 30088592 )
2018
Sources

Variations for Bruxism

About this section

ClinVar genetic disease variations for Bruxism:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MECP2 NM_004992.3(MECP2): c.377+1G> T single nucleotide variant Pathogenic rs267608463 GRCh38 Chromosome X, 154032206: 154032206
2 MECP2 NM_004992.3(MECP2): c.377+1G> T single nucleotide variant Pathogenic rs267608463 GRCh37 Chromosome X, 153297657: 153297657
3 CDKL5 NM_003159.2(CDKL5): c.622C> T (p.Gln208Ter) single nucleotide variant Pathogenic rs587783405 GRCh37 Chromosome X, 18606141: 18606141
4 CDKL5 NM_003159.2(CDKL5): c.622C> T (p.Gln208Ter) single nucleotide variant Pathogenic rs587783405 GRCh38 Chromosome X, 18588021: 18588021
Sources

Expression for Bruxism

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Search GEO for disease gene expression data for Bruxism.
Sources

Pathways for Bruxism

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Pathways related to Bruxism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dopamine-DARPP32 Feedback onto cAMP Pathway 64
11.69 DRD2 DRD3 DRD5
2
Monoamine GPCRs 1
Show member pathways
 11.32 DRD2 DRD3 DRD5 HTR2A
3
DARPP-32 Phosphorylation 65
10.14 DRD2 DRD3 DRD5
Sources

GO Terms for Bruxism

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Cellular components related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutamatergic synapse GO:0098978 9.26 CDKL5 DRD2 DRD3 HTR2A
2 non-motile cilium GO:0097730 9.16 DRD2 DRD5
3 dopaminergic synapse GO:0098691 8.62 DRD2 DRD3

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.75 DRD3 DRD5 HTR2A
2 release of sequestered calcium ion into cytosol GO:0051209 9.66 DRD2 HTR2A
3 positive regulation of cytokinesis GO:0032467 9.65 DRD2 DRD3
4 long-term memory GO:0007616 9.65 DRD2 MECP2
5 regulation of dopamine secretion GO:0014059 9.65 DRD3 HTR2A
6 visual learning GO:0008542 9.65 DRD2 DRD3 MECP2
7 associative learning GO:0008306 9.64 DRD2 DRD5
8 response to morphine GO:0043278 9.64 DRD2 DRD3
9 arachidonic acid secretion GO:0050482 9.63 DRD2 DRD3
10 temperature homeostasis GO:0001659 9.63 DRD2 HTR2A
11 response to cocaine GO:0042220 9.63 DRD2 DRD3 DRD5
12 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.62 DRD2 DRD3
13 dopamine receptor signaling pathway GO:0007212 9.62 DRD2 DRD3
14 negative regulation of protein secretion GO:0050709 9.61 DRD2 DRD3
15 startle response GO:0001964 9.61 DRD2 MECP2
16 dopamine metabolic process GO:0042417 9.6 DRD2 DRD3
17 prepulse inhibition GO:0060134 9.59 DRD2 DRD3
18 positive regulation of renal sodium excretion GO:0035815 9.58 DRD2 DRD3
19 G protein-coupled receptor internalization GO:0002031 9.57 DRD2 DRD3
20 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.56 DRD3 DRD5
21 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.55 DRD2 DRD3
22 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.54 DRD2 HTR2A
23 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.52 DRD2 DRD5
24 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.51 DRD2 DRD3
25 response to amphetamine GO:0001975 9.5 DRD2 DRD3 DRD5
26 negative regulation of dopamine receptor signaling pathway GO:0060160 9.49 DRD2 DRD3
27 acid secretion GO:0046717 9.43 DRD2 DRD3
28 regulation of locomotion involved in locomotory behavior GO:0090325 9.4 DRD2 DRD3
29 response to histamine GO:0034776 9.37 DRD2 DRD3
30 negative regulation of blood pressure GO:0045776 9.33 DRD2 DRD3 DRD5
31 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 9.26 DRD2 MECP2
32 behavioral response to cocaine GO:0048148 9.13 DRD2 DRD3 HTR2A
33 synaptic transmission, dopaminergic GO:0001963 8.8 DRD2 DRD3 DRD5

Molecular functions related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein alpha-subunit binding GO:0001965 9.37 DRD5 HTR2A
2 drug binding GO:0008144 9.33 DRD2 DRD3 HTR2A
3 adrenergic receptor activity GO:0004935 9.32 DRD2 DRD3
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.26 DRD2 DRD3
5 dopamine binding GO:0035240 9.13 DRD2 DRD3 DRD5
6 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD2 DRD3 DRD5
Sources

Sources for Bruxism

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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