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MCID: BRX001
MIFTS: 50

Bruxism

Categories: Mental diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bruxism

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MalaCards integrated aliases for Bruxism:

Name: Bruxism 12 54 6 43 15 71
Sleep Bruxism 43 71
Bruxism - Teeth Grinding 12
Sleep Related Bruxism 12
Sleep-Related Bruxism 71
Grinding Teeth 12
Teeth Grinding 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Oral diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:2846
ICD9CM 34 327.53
NCIt 49 C73511
SNOMED-CT 67 90207007
ICD10 32 F45.8 G47.63
UMLS 71 C0006325 C0393774 C0751771
Sources

Summaries for Bruxism

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Disease Ontology : 12 A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping.

MalaCards based summary : Bruxism, also known as sleep bruxism, is related to sleep disorder and depression, and has symptoms including excessive daytime somnolence, snoring and sleep disturbances. An important gene associated with Bruxism is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Serotonergic synapse. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and eye, and related phenotypes are Strongly decreased NFAT1-GFP nuclear translocation and behavior/neurological

Wikipedia : 74 Bruxism is excessive teeth grinding or jaw clenching. It is an oral parafunctional activity; i.e., it is... more...

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Related Diseases for Bruxism

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Diseases related to Bruxism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 232)
# Related Disease Score Top Affiliating Genes
1 sleep disorder 31.6 SLC6A4 HTR2A HTR1A DRD2
2 depression 31.1 SLC6A4 HTR2A HTR1A
3 movement disease 31.1 VPS13A OMD DRD5 DRD3 DRD2
4 anxiety 31.0 SLC6A4 HTR2A HTR1A DRD3 DRD2
5 gastroesophageal reflux 30.9 MECP2 HTR2A DRD2
6 restless legs syndrome 30.9 SLC6A4 DRD5 DRD3 DRD2
7 migraine with or without aura 1 30.8 SLC6A4 HTR2A HTR1A DRD5 DRD3 DRD2
8 mental depression 30.8 SLC6A4 HTR2A HTR1A DRD2
9 generalized anxiety disorder 30.8 SLC6A4 HTR2A HTR1A DRD2
10 tic disorder 30.7 SLC6A4 HTR2A DRD5 DRD3 DRD2
11 dystonia 30.7 WDR45 VPS13A MECP2 HTR2A DRD5 DRD3
12 conduct disorder 30.6 SLC6A4 DRD5 DRD2
13 social phobia 30.6 SLC6A4 HTR1A DRD2
14 major depressive disorder 30.5 SLC6A4 HTR2A HTR1A DRD3 DRD2
15 rett syndrome 30.5 MECP2 FOXG1 DRD2 CDKL5
16 attention deficit-hyperactivity disorder 30.5 SLC6A4 MECP2 HTR2A HTR1A DRD5 DRD3
17 focal dystonia 30.5 OMD DRD5 DRD2
18 alexithymia 30.4 SLC6A4 HTR1A DRD2
19 fibromyalgia 30.4 SLC6A4 HTR2A DRD2
20 agoraphobia 30.4 SLC6A4 HTR2A HTR1A
21 obsessive-compulsive disorder 30.3 SLC6A4 HTR2A HTR1A DRD3 DRD2
22 post-traumatic stress disorder 30.3 SLC6A4 HTR2A DRD2
23 early infantile epileptic encephalopathy 30.1 MECP2 IQSEC2 FOXG1 CDKL5
24 tobacco addiction 30.1 SLC6A4 LCOR HTR2A DRD5 DRD3 DRD2
25 substance abuse 30.0 SLC6A4 HTR2A HTR1A DRD5 DRD3 DRD2
26 panic disorder 30.0 SLC6A4 HTR2A HTR1A DRD5 DRD3 DRD2
27 alcohol dependence 30.0 SLC6A4 HTR2A HTR1A DRD5 DRD3 DRD2
28 disease of mental health 29.9 SLC6A4 MECP2 HTR2A HTR1A DRD5 DRD3
29 parkinson disease, late-onset 29.8 SLC6A4 HTR2A HTR1A DRD5 DRD3 DRD2
30 bipolar disorder 29.8 SLC6A4 MECP2 HTR2A HTR1A DRD5 DRD3
31 autism 29.6 SLC6A4 MECP2 IQSEC2 HTR2A HTR1A FOXG1
32 pervasive developmental disorder 29.5 SLC6A4 MECP2 HTR2A HTR1A FOXG1 DRD5
33 parasomnia, sleep bruxism type 12.6
34 epileptic encephalopathy, early infantile, 2 11.2
35 neurodegeneration with brain iron accumulation 5 11.2
36 neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia 11.2
37 oromandibular dystonia 11.2
38 mecp2 disorders 10.6 MECP2 FOXG1
39 sleep apnea 10.6
40 headache 10.6
41 idiopathic corneal edema 10.6 DRD5 DRD3 DRD2
42 polysubstance abuse 10.6 DRD3 DRD2
43 tardive dyskinesia 10.6 HTR2A DRD3 DRD2
44 periodic limb movement disorder 10.5 DRD5 DRD3 DRD2
45 gait apraxia 10.5 MECP2 FOXG1 CDKL5
46 chronic tic disorder 10.5 DRD5 DRD3 DRD2
47 mixed cerebral palsy 10.5 DRD5 DRD3 DRD2
48 opioid abuse 10.5 DRD5 DRD3 DRD2
49 schizophrenia 5 10.5 HTR2A HTR1A DRD2
50 christianson syndrome 10.5 MECP2 FOXG1 CDKL5

Graphical network of the top 20 diseases related to Bruxism:



Diseases related to Bruxism
Sources

Symptoms & Phenotypes for Bruxism

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UMLS symptoms related to Bruxism:


excessive daytime somnolence, snoring, sleep disturbances, sleeplessness, mental and behavioral signs and symptoms, toothache, teeth chattering

GenomeRNAi Phenotypes related to Bruxism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Strongly decreased NFAT1-GFP nuclear translocation GR00359-A 9.1 FGF7 HTR1A LCOR SLC6A4 VPS13A WRNIP1

MGI Mouse Phenotypes related to Bruxism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.44 CDKL5 DRD2 DRD3 DRD5 FGF7 FOXG1
Sources

Drugs & Therapeutics for Bruxism

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Drugs for Bruxism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 97)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
5
Morphine Approved, Investigational Phase 4 57-27-2 5288826
6
Codeine Approved, Illicit Phase 4 76-57-3 5284371
7
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
8
carbamide peroxide Approved Phase 4 124-43-6
9
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
10
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12 Analgesics Phase 4
13 Anti-Infective Agents Phase 4
14 Autonomic Agents Phase 4
15 Anti-Inflammatory Agents Phase 4
16 Gastrointestinal Agents Phase 4
17 HIV Protease Inhibitors Phase 4
18 Respiratory System Agents Phase 4
19
protease inhibitors Phase 4
20 Narcotics Phase 4
21 Hypnotics and Sedatives Phase 4
22 Antipyretics Phase 4
23 Cyclooxygenase Inhibitors Phase 4
24 Anti-Inflammatory Agents, Non-Steroidal Phase 4
25 Analgesics, Opioid Phase 4
26 BB 1101 Phase 4
27 Analgesics, Non-Narcotic Phase 4
28 Hormone Antagonists Phase 4
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
30 Antirheumatic Agents Phase 4
31 Antitussive Agents Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 glucocorticoids Phase 4
34 Hormones Phase 4
35 Antiemetics Phase 4
36 Anti-Infective Agents, Local Phase 4
37 Tranquilizing Agents Phase 4
38 Psychotropic Drugs Phase 4
39 Antidepressive Agents Phase 4
40 Anti-Anxiety Agents Phase 4
41 Serotonin Agents Phase 4
42 Serotonin Uptake Inhibitors Phase 4
43 Central Nervous System Depressants Phase 4
44 Neurotransmitter Agents Phase 4
45 Acetylcholine Release Inhibitors Phase 4
46 Botulinum Toxins Phase 4
47 Cholinergic Agents Phase 4
48 Anesthetics, Local Phase 4
49 Anti-Arrhythmia Agents Phase 4
50 Anesthetics Phase 4

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 Effects of Botulinum Toxin Type A(Meditoxin®) on Sleep Bruxism by Different Injection Sites Evaluated by Polysomnography Unknown status NCT01336439 Phase 4 Botulinum toxin type A (Meditoxin®)
2 DOUBLE BLIND, PLACEBO CONTROLLED, RANDOMIZED CLINICAL TRIAL OF THE SAFETY AND EFFICACY OF BOTULINUM TOXIN TYPE A (BOTOX) IN BRUXISM Unknown status NCT00908050 Phase 4 Botulinum toxin type A
3 Comparison of Effects of Naproxen Sodium-codeine Phosphate in Combination, Naproxen Sodium + Single Dose Dexamethasone and Naproxen Sodium Alone on Pain and Trismus in Patients With Temporomandibular Disorder Completed NCT04066426 Phase 4 naproxen sodium+codeine phosphate, naproxen sodium+dexamethasone, naproxen sodium, paracetamol
4 "Evaluation of the Effectiveness and Longevity Post Whitening Carbamide Peroxide 10% in Smokers and Nonsmokers. Double-blind Multicenter Clinical Trial. " Completed NCT02017873 Phase 4 Peroxide Carbamide 10% - Dental bleaching treatment
5 Stabilisation de la qualité du Sommeil Chez le Sujet en Douleurs Orofaciales Chroniques - étude expérimentale en chassé croisé : Trazodone/ Placebo Recruiting NCT03522207 Phase 4 Trazodone;Placebos;Trazodone;placebos
6 Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques Terminated NCT00992108 Phase 4 lidocaine;chemodenervation
7 Efficacy of Phytolacca Decandra and Melissa Officinalis in Children With Nocturnal Bruxism: a Controlled and Randomized Clinical Trial Unknown status NCT02870543 Phase 3 Phytolacca decandra;Melissa officinalis;Phyt.decandra + Melissa offic.
8 Resin Based Composite Occlusal Restoration Postoperative Hypersensitivity: Randomized Comparative Effectiveness Research Trial Completed NCT01268605 Phase 3
9 The Platelet -Rich Plasma in the Therapy of Temporomandibular Disorders Completed NCT03371888 Phase 2, Phase 3
10 The Influence of Oral Vibrational Stimulation on Brain Activity and Cognitive Function of Elderly Individuals With Mild Cognitive Impairment Unknown status NCT02332525 Phase 1, Phase 2
11 Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study Unknown status NCT02810015 Phase 2 Botulinum Toxin Type A
12 AWARNESS THROUGH MOVEMENT PHYSIOTERAPEUTIC TECHNIQUE INCREASED THE AIRWAY DIMENSIONS OF BRUXIST CHILDREN: A SINGLE BLIND RANDOMIZED CLINICAL TRIAL. Completed NCT01178229 Phase 1, Phase 2
13 Basis for an Etiological Diagnosis and Treatment of the Chronic TMD-pain: RCT Study Completed NCT00899717 Phase 1, Phase 2
14 Evaluation of the Effectiveness of Infrared LED Photobiomodulation in Children With Sleep Bruxism: Study Protocol for Randomized Clinical Trial. Recruiting NCT03710174 Phase 2
15 Botulinum Toxin A Injectable Solution in the Management of Bruxism Recruiting NCT03827122 Phase 2 onabotulinumtoxinA
16 Phase 1 Study of Role of Botox in Myofascial Temporomandibular Disorder Withdrawn NCT02202070 Phase 1 onabotulinumtoxinA
17 A Pilot Study of the TMJ NextGeneration Compared to the DSG Relaxer for Reduction in Nocturnal Bruxism Episodes in Subjects Diagnosed With Sleep Bruxism Unknown status NCT02446288
18 Effectiveness of Physical Therapy Interventions, Relative to Dental Treatment in Individuals With Bruxism: a Randomized Clinical Trial Unknown status NCT01778881
19 Evaluation of Muscle Activity, Bite Force and Salivary Cortisol in Children With Bruxism Before and After Laser Use of Low Power in Acupoints- Controlled Clinical Trial Unknown status NCT02757261 Early Phase 1
20 Relationship of Facial Pattern With Bruxism Unknown status NCT00868244
21 Prevalence of Bruxism in a Group of Preschool Egyptian Children Unknown status NCT03006133
22 Reduction of Masticatory Muscle Activity by Restoring Canine Guidance With Composite Resin Fillings in Patients With Bruxism. Unknown status NCT02235220
23 The Prevalence and Risk Factors for Patients With Peri-implant Disease：a Retrospective Study Unknown status NCT02662361
24 Analysis of the Prevalence and Characteristics of Co-Morbid Sleep and Headache Disorders in Patients Being Evaluated at the WRAMC Sleep Disorders Laboratory, and the Efficacy of CPAP Treatment on Headache Burden in Obstructive Sleep Apnea Patients With a Co-Morbid Headache Disorder Unknown status NCT00520156
25 Evaluation of Accuracy in Computer Guided Versus Free Hand Immediate Implant Placement in Fresh Extraction Sockets: a Randomized Controlled Clinical Trial Unknown status NCT03281148
26 Clinical Condition and Sleep Quality Factors Associated With Sleep Bruxism in Adults: a Study Using Polysomnography. Completed NCT04015349
27 Sleep Architecture and Factors Associated With Definitive Diagnosis of Sleep Bruxism: a Case-control Study Completed NCT03825237
28 The Efficacy of Gabapentine and Splint Therapy in Bruxers: a Randomized Clinical Trial Completed NCT01255878 Gabapentine
29 Interest of the BRUXENSE Occlusal Splints for Bruxism Diagnosis: a Feasibility Study Completed NCT03363204
30 A Clinical Trial of the Optimal Treatment Period and Long-term Efficacy of Functional Electrical Stimulation (FES) on Sleep Bruxism Completed NCT01000389
31 Effects of Dry Needling in Patients With Sleep Bruxism and Temporomandibular Disorders: a Prospective Case Series Completed NCT02587182
32 Evaluation of Relationship Between Enterobius Vermicularis Infection and Bruxism in Children Completed NCT03833505
33 The Treatment of Sleep Bruxism With the Luco Hybrid OSA Appliance Completed NCT02882880
34 Associations Between Sleep Bruxism and (Peri-)Implant Complications: a Follow-up Study Completed NCT02410681
35 Floral Remedies for Sleep Bruxism Patients: A Randomized Trial for Attenuating Temporal Cephalic Pain Completed NCT03112954 Buccal-relaxant formula;Placebo
36 Assessment The Effects of Proprioceptive Neuromuscular Facilitation, Myofascial Releasing Maneuvers and Home Exercises on Pain and Jaw Function in Patients With Bruxism Completed NCT03499665
37 A Feasibility Study of the Bruxoffâ„¢ Device to Assess EMG Activity in Subjects Diagnosed With Sleep Bruxism Using TMJ NextGeneration(TM) Completed NCT02257320
38 Preliminary Phase IV Trial Comparing the SOVA Night Guard With the Clinical Standard Acrylic Orthotic Completed NCT02340663
39 Association Between Respiratory Problem and Dental Caries in Children With Bruxism Completed NCT01463826
40 Effects of the Continuous Wear of Invisalign® Trays on the Temporomandibular Joints and Orofacial Muscular Complex Completed NCT01812850
41 Oral Appliance in the Treatment of Obstructive Sleep Apnea. A Randomized Controlled Blinded Multicenter Study Comparing the Efficacy of Two Devices Completed NCT02148510
42 Feasibility Study Regarding the Implantation and Use of Rechargeable Neurostimulators in Deep Brain Stimulation for Psychiatric Disorders (Either Obsessive-compulsive Disorder or Major Depression) Completed NCT02685280
43 The Effects of Mindfulness and RelaxationTraining for Insomnia (MRTI) on Postmenopausal Women: a Randomized Clinical Trial. Completed NCT01593436
44 Which One is Effective in Treatment of Bruxism? Occlusal Splints or Botulinum Toxin Completed NCT03891121 Botulinum toxin type A
45 Postoperative Evaluation of the Intraoral Technique of Buccal Fat Pad Removal Completed NCT03974373
46 Effectiveness of Laser Therapy Associated With Fluoride Therapy in Hypomineralized Teeth Desensibilization: Randomized Clinical Trial Completed NCT03823170
47 COMPARISION OF DIFFERENT TREATMENT METHODS OF PERI-IMPLANTITIS Completed NCT03241953
48 Fiber-reinforced Composite Core Filling in the Restoration of Endodontically Treated Molars - a Clinical Study Completed NCT04111003
49 Analysis of Clinical Wear Patterns of Tooth Enamel and Ceramic Restorations as a Function of Particle Size, Inter-Particle Spacing and Fracture Toughness of Ceramic Crystals Completed NCT00223405
50 The Effect of Different Dental Implant Surface Characteristics on Bone Immunological Biomarkers and Microbiological Parameters: A Randomized Clinical Study Completed NCT03693196

Search NIH Clinical Center for Bruxism

Cochrane evidence based reviews: bruxism

Sources

Genetic Tests for Bruxism

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Sources

Anatomical Context for Bruxism

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MalaCards organs/tissues related to Bruxism:

40
Brain, Bone, Eye, Tongue, Heart, Thyroid, Testes
Sources

Publications for Bruxism

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Articles related to Bruxism:

(show top 50) (show all 2321)
# Title Authors PMID Year
1
Stereotypies in Rett syndrome: analysis of 83 patients with and without detected MECP2 mutations. 54 61
17420401 2007
2
Double-blind, crossover, placebo-controlled trial of bromocriptine in patients with sleep bruxism. 54 61
11391125 2001
3
[Study on the correlation between the mandibular masticatory muscle movement and sleep tooth wear]. 61
32037767 2020
4
Interventions to reduce bruxism in children and adolescents: a systematic scoping review and critical reflection. 61
31858254 2020
5
Consensus-based clinical guidelines for ambulatory electromyography and contingent electrical stimulation in sleep bruxism. 61
31430389 2020
6
Questions on the clinical applicability on the international consensus on the assessment of bruxism. 61
31562643 2020
7
The approach and management of bruxism in Alzheimer's disease: An under-recognized habit that concerns caregivers (innovative practice). 61
28201931 2020
8
Changes in heart rate related to rhythmic masticatory muscle activities and limb movements in patients with sleep bruxism. 61
31697853 2020
9
Do family functioning and mothers' and children's stress increase the odds of probable sleep bruxism among schoolchildren? A case control study. 61
31286259 2020
10
Eye movements in relation to rhythmic masticatory muscle activities in patients with sleep bruxism. 61
31707287 2020
11
A polysomnographic study on the relationship between sleep bruxism intensity and sleep quality. 61
31969083 2020
12
Effect of experimental temporomandibular disorder pain on sleep bruxism: a pilot study in males. 61
31028465 2020
13
Atomoxetine-related bruxism in a 7-year-old boy: A case report. 61
32001942 2020
14
Symptoms of temporomandibular disorder, self-reported bruxism, and the risk of implant failure: A retrospective analysis. 61
29985773 2020
15
Towards a Standardized Tool for the Assessment of Bruxism (STAB) - Overview and general remarks of a multidimensional bruxism evaluation system. 61
31999846 2020
16
Evaluation of the mandibular trabecular bone in patients with bruxism using fractal analysis. 61
31933121 2020
17
Recording of bruxism events in sleeping humans at home with a smart instrumented splint. 61
31914871 2020
18
Sleep stage dynamics in young patients with sleep bruxism. 61
31554012 2020
19
Coherence of jaw and neck muscle activity during sleep bruxism. 61
31926031 2020
20
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
21
Sleep-Related Movement Disorders In A Population Of Patients With Epilepsy: Prevalence And Impact Of Restless Legs Syndrome And Sleep Bruxism. 61
31992428 2020
22
Critical Issues in Dental and Medical Management of Obstructive Sleep Apnea. 61
31702942 2020
23
There are probably similar outcomes between a glass-hybrid restorative and a nanoceramic composite resin after 2 years of restoring noncarious cervical lesions in patients with bruxism. 61
31732090 2020
24
Probable Sleep Bruxism in Children and its Relationship with Harmful Oral Habits, Type of Crossbite and Oral Breathing. 61
31995421 2020
25
High separation anxiety trajectory in early childhood is a risk factor for sleep bruxism at age 7. 61
31894243 2020
26
Evaluation of tissue oxygen saturation of the masseter muscle during standardised teeth clenching. 61
31332831 2020
27
Survival rates and prosthetic complications of implant fixed complete dental prostheses: An up to 5-year retrospective study. 61
31982146 2020
28
Technical Complications and Prosthesis Survival Rates with Implant-Supported Fixed Complete Dental Prostheses: A Retrospective Study with 1- to 12-Year Follow-Up. 61
31650669 2020
29
The one-step no-prep approach for full-mouth rehabilitation of worn dentition using PICN CAD-CAM restorations: 2-yr results of a prospective clinical study. 61
31747585 2020
30
Incidence and prevalence of peri-implantitis and peri-implant mucositis 17 to 23 (18.9) years postimplant placement. 61
31692243 2019
31
Relationship between self-reported bruxism and periodontal status: Findings from a cross-sectional study. 61
31850520 2019
32
Are maternal mental disorders associated with children's oral health? A systematic review. 61
31849127 2019
33
Application of botulinum toxin in maxillofacial field: Part II. Wrinkle, intraoral ulcer, and cranio-maxillofacial pain. 61
31649903 2019
34
Self-Perceptions of the Impact of Oral Problems on the Social Behavior of Preschoolers. 61
31847730 2019
35
Clinical behavior of second-generation zirconia monolithic posterior restorations: Two-year results of a prospective study with Ex vivo analyses including patients with clinical signs of bruxism. 61
31722238 2019
36
Two middle-aged women with the Finnish variant of muscle-eye-brain disease (MEB). 61
31580529 2019
37
Botulinum Toxin Type A in Dental Medicine. 61
31533008 2019
38
Comorbid episodes of primary bruxism and bruxism as an epileptic activity-related motor event. 61
31655318 2019
39
Sleep-Related Bruxism Response to Melatonin Treatment. 61
31800301 2019
40
The Relationship between Sleep Bruxism Intensity and Renalase Concentration-An Enzyme Involved in Hypertension Development. 61
31861602 2019
41
Which Treatment Is Effective for Bruxism: Occlusal Splints or Botulinum Toxin? 61
31302066 2019
42
Intelligent Occlusion Stabilization Splint with Stress-Sensor System for Bruxism Diagnosis and Treatment. 61
31877845 2019
43
Minimum measurement time of masseteric electromyogram required for assessment of awake bruxism during the daytime. 61
31856680 2019
44
Application of botulinum toxin in maxillofacial field: part I. Bruxism and square jaw. 61
31649901 2019
45
The flexural strength of CAD/CAM polymer crowns and the effect of artificial ageing on the fracture resistance of CAD/CAM polymer and ceramic single crowns. 61
31872290 2019
46
Efficacy of Biofeedback for Medical Conditions: an Evidence Map. 61
31414354 2019
47
Tongue force, oral health-related quality of life, and sleep index after bruxism management with intraoral devices. 61
31831164 2019
48
Single nucleotide polymorphisms in dopamine receptor D2 are associated with bruxism and its circadian phenotypes in children. 61
31868570 2019
49
Application of botulinum toxin in maxillofacial field: Part III. Ancillary treatment for maxillofacial surgery and summary. 61
31709199 2019
50
Absence of joint pain identifies high levels of sleep masticatory muscle activity in myofascial temporomandibular disorder. 61
31271666 2019
Sources

Variations for Bruxism

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ClinVar genetic disease variations for Bruxism:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MECP2 NM_004992.3(MECP2):c.377+1G>TSNV Pathogenic 156053 rs267608463 X:153297657-153297657 X:154032206-154032206
2 CDKL5 NM_001323289.2(CDKL5):c.622C>T (p.Gln208Ter)SNV Pathogenic 158186 rs587783405 X:18606141-18606141 X:18588021-18588021
Sources

Expression for Bruxism

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Search GEO for disease gene expression data for Bruxism.
Sources

Pathways for Bruxism

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Pathways related to Bruxism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.83 SLC6A4 MECP2 HTR2A HTR1A
2
Serotonergic synapse 36
11.6 SLC6A4 HTR2A HTR1A
3
Monoamine GPCRs 1
Show member pathways
 11.4 HTR2A HTR1A DRD5 DRD3 DRD2
4
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
10.88 SLC6A4 HTR2A HTR1A
5
DARPP-32 Phosphorylation 64
10.67 DRD5 DRD3 DRD2
6
Methylphenidate Pathway, Pharmacodynamics 60
Show member pathways
 10.38 SLC6A4 HTR1A DRD5 DRD3 DRD2
Sources

GO Terms for Bruxism

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Cellular components related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dopaminergic synapse GO:0098691 9.16 DRD3 DRD2
2 integral component of presynaptic membrane GO:0099056 9.13 SLC6A4 HTR2A DRD2
3 integral component of postsynaptic membrane GO:0099055 8.8 SLC6A4 HTR2A DRD2

Biological processes related to Bruxism according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.04 MECP2 HTR2A HTR1A FGF7 DRD3
2 response to drug GO:0042493 9.99 SLC6A4 HTR2A DRD3 DRD2
3 chemical synaptic transmission GO:0007268 9.93 MECP2 HTR2A HTR1A DRD5
4 autophagy GO:0006914 9.88 WDR45 VPS13A DRD3 DRD2
5 cellular calcium ion homeostasis GO:0006874 9.85 HTR2A DRD5 DRD3
6 response to toxic substance GO:0009636 9.83 SLC6A4 DRD3 DRD2
7 locomotory behavior GO:0007626 9.82 VPS13A DRD3 DRD2
8 memory GO:0007613 9.81 SLC6A4 MECP2 HTR2A
9 protein localization GO:0008104 9.8 VPS13A MECP2 DRD2
10 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.77 DRD5 DRD3 DRD2
11 visual learning GO:0008542 9.75 MECP2 DRD3 DRD2
12 response to cocaine GO:0042220 9.71 DRD5 DRD3 DRD2
13 response to amphetamine GO:0001975 9.7 DRD5 DRD3 DRD2
14 temperature homeostasis GO:0001659 9.69 HTR2A DRD2
15 dopamine receptor signaling pathway GO:0007212 9.69 DRD3 DRD2
16 negative regulation of cytosolic calcium ion concentration GO:0051481 9.69 DRD3 DRD2
17 vasoconstriction GO:0042310 9.68 SLC6A4 HTR1A
18 startle response GO:0001964 9.68 MECP2 DRD2
19 negative regulation of voltage-gated calcium channel activity GO:1901386 9.67 DRD3 DRD2
20 prepulse inhibition GO:0060134 9.67 DRD3 DRD2
21 behavioral response to ethanol GO:0048149 9.67 DRD3 DRD2
22 dopamine metabolic process GO:0042417 9.66 DRD3 DRD2
23 positive regulation of renal sodium excretion GO:0035815 9.65 DRD3 DRD2
24 G protein-coupled receptor internalization GO:0002031 9.65 DRD3 DRD2
25 regulation of dopamine secretion GO:0014059 9.63 HTR2A DRD3 DRD2
26 regulation of potassium ion transport GO:0043266 9.62 DRD3 DRD2
27 behavior GO:0007610 9.62 HTR2A HTR1A
28 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.61 DRD5 DRD3
29 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.61 DRD3 DRD2
30 negative regulation of blood pressure GO:0045776 9.61 DRD5 DRD3 DRD2
31 serotonin receptor signaling pathway GO:0007210 9.6 HTR2A HTR1A
32 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.57 DRD3 DRD2
33 negative regulation of dopamine receptor signaling pathway GO:0060160 9.56 DRD3 DRD2
34 regulation of neurotransmitter uptake GO:0051580 9.55 DRD3 DRD2
35 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.54 DRD5 DRD3 DRD2
36 regulation of locomotion involved in locomotory behavior GO:0090325 9.51 DRD3 DRD2
37 behavioral response to cocaine GO:0048148 9.5 HTR2A DRD3 DRD2
38 acid secretion GO:0046717 9.49 DRD3 DRD2
39 response to histamine GO:0034776 9.48 DRD3 DRD2
40 synaptic transmission, dopaminergic GO:0001963 9.43 DRD5 DRD3 DRD2
41 neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 9.4 MECP2 DRD2
42 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.33 HTR2A DRD3 DRD2
43 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.13 DRD5 DRD3 DRD2
44 social behavior GO:0035176 8.92 VPS13A SLC6A4 MECP2 DRD3

Molecular functions related to Bruxism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.54 HTR2A DRD3 DRD2
2 adrenergic receptor activity GO:0004935 9.43 DRD5 DRD3 DRD2
3 dopamine binding GO:0035240 9.33 DRD5 DRD3 DRD2
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD3 DRD2
5 serotonin binding GO:0051378 9.13 SLC6A4 HTR2A HTR1A
6 dopamine neurotransmitter receptor activity GO:0004952 8.8 DRD5 DRD3 DRD2
Sources

Sources for Bruxism

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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