MCID: BBN001
MIFTS: 40

Bubonic Plague

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Bubonic Plague

MalaCards integrated aliases for Bubonic Plague:

Name: Bubonic Plague 12 73 20 54 15 70 32
Plague, Septicemic 70
Plague, Bubonic 73
Black Death 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10773
ICD9CM 34 020.0
MeSH 44 D010930
SNOMED-CT 67 50797007
ICD10 32 A20.0
UMLS 70 C0152936 C0282312

Summaries for Bubonic Plague

Disease Ontology : 12 A plague that results in infection located in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has symptom enlarged, tender lymph nodes, has symptom fever, has symptom chills and has symptom prostration.

MalaCards based summary : Bubonic Plague, also known as plague, septicemic, is related to plague and pneumonic plague, and has symptoms including fever, chills and enlarged. An important gene associated with Bubonic Plague is PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1), and among its related pathways/superpathways are Measles and Necroptosis. The drugs Streptomycin and Ciprofloxacin have been mentioned in the context of this disorder. Affiliated tissues include lymph node producing a bubo, lymph node and skin.

Wikipedia : 73 Bubonic plague is one of three types of plague caused by the plague bacterium (Yersinia pestis). One to... more...

Related Diseases for Bubonic Plague

Diseases related to Bubonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 plague 30.6 VCAN TLR4 TLR2 SULT1A2 SULT1A1 SLC25A6
2 pneumonic plague 30.4 VCAN TLR4 TLR2 SULT1A2 SULT1A1 SERPINF2
3 septicemic plague 30.4 VCAN SULT1A2 SERPINF2 PLG
4 disease by infectious agent 10.2
5 toxic shock syndrome 10.2
6 lymphadenitis 10.2
7 tularemia 10.2
8 livedoid vasculitis 10.2 SERPINF2 PLG
9 plasminogen deficiency, type i 10.2 SERPINF2 PLG
10 prosthetic joint infection 10.2 TLR4 TLR2
11 fungal keratitis 10.1 TLR4 TLR2
12 intracranial embolism 10.1 SERPINF2 PLG
13 chronic purulent otitis media 10.1 TLR4 TLR2
14 neisseria meningitidis infection 10.1 TLR4 TLR2
15 perforated corneal ulcer 10.1 SERPINF2 PLG
16 congenital cytomegalovirus 10.1 TLR4 TLR2
17 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
18 epidemic typhus 10.1
19 endemic typhus 10.1
20 autosomal recessive cerebellar ataxia 10.1
21 filariasis 10.1
22 respiratory failure 10.1
23 tetanus 10.1
24 filarial elephantiasis 10.1
25 cholera 10.1
26 anthrax disease 10.1
27 yellow fever 10.1
28 fallopian tube disease 10.1 TLR4 TLR2 CCR5
29 vaginal disease 10.1 TLR4 TLR2 CCR5
30 hereditary angioedema with normal c1inh 10.1 TLR4 TLR2 PLG
31 coccidiosis 10.1 TLR4 TLR2 CCR5
32 anus disease 10.1 TLR4 TLR2 CCR5
33 superficial basal cell carcinoma 10.1 TLR4 TLR2
34 rectal disease 10.1 TLR4 TLR2 CCR5
35 invasive aspergillosis 10.0 TLR4 TLR2 PLG
36 ileitis 10.0 TLR4 TLR2 CCR5
37 aspergillosis 10.0 TLR4 TLR2 PLG
38 gastrointestinal tularemia 10.0 TLR4 TLR2
39 reactive arthritis 10.0 TLR4 TLR2 CCR5
40 aggressive periodontitis 10.0 TLR4 TLR2 CTSC
41 periodontitis 10.0 TLR4 TLR2 CTSC
42 parasitic protozoa infectious disease 10.0 TLR4 TLR2 CCR5
43 toxoplasmosis 10.0 TLR4 TLR2 CCR5
44 primary bacterial infectious disease 10.0 TLR4 TLR2 CCR5
45 silo filler's disease 10.0 TLR4 TLR2
46 otitis media 10.0 TLR4 TLR2 PLG
47 chagas disease 10.0 TLR4 TLR2 CCR5
48 pneumonic tularemia 10.0 TLR4 TLR2
49 melioidosis 9.9 TLR4 TLR2 SERPINF2
50 variola major 9.9

Graphical network of the top 20 diseases related to Bubonic Plague:



Diseases related to Bubonic Plague

Symptoms & Phenotypes for Bubonic Plague

Symptoms:

12
  • fever
  • chills
  • enlarged
  • prostration

Drugs & Therapeutics for Bubonic Plague

Drugs for Bubonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 3 57-92-1 19649
2
Ciprofloxacin Approved, Investigational Phase 3 85721-33-1 2764
3 Gentamicins Phase 2, Phase 3
4 Anti-Bacterial Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Cytochrome P-450 Enzyme Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Gentamicin Versus Streptomycin for the Treatment of Naturally Occurring Human Plague and Evaluation of Rapid Diagnostic Test Kits for Yersinia Pestis Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 An Open-label, Randomised, Non-inferiority Trial of the Efficacy and Safety of Ciprofloxacin Versus Streptomycin + Ciprofloxacin in the Treatment of Bubonic Plague Recruiting NCT04110340 Phase 3 Ciprofloxacin;Streptomycin

Search NIH Clinical Center for Bubonic Plague

Genetic Tests for Bubonic Plague

Anatomical Context for Bubonic Plague

The Foundational Model of Anatomy Ontology organs/tissues related to Bubonic Plague:

19
Lymph Node Producing A Bubo

MalaCards organs/tissues related to Bubonic Plague:

40
Lymph Node, Skin, Neutrophil, Spleen, T Cells, Liver

Publications for Bubonic Plague

Articles related to Bubonic Plague:

(show top 50) (show all 570)
# Title Authors PMID Year
1
Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors. 61 54
15781408 2005
2
Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases. 54 61
14734566 2004
3
High-resolution structure of the Yersinia pestis protein tyrosine phosphatase YopH in complex with a phosphotyrosyl mimetic-containing hexapeptide. 61 54
14609321 2003
4
Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. 54 61
8052312 1994
5
Microbial pathogenesis and tyrosine dephosphorylation: surprising 'bedfellows'. 61 54
1723471 1991
6
Genghis Khan's death (AD 1227): An unsolvable riddle or simply a pandemic disease? 61
33444749 2021
7
History of the Plague: An Ancient Pandemic for the Age of COVID-19. 61
32979306 2021
8
Are we Athens or Florence? COVID-19 in historical context. 61
33526435 2021
9
Spatiotemporal analysis of bubonic plague in Pernambuco, northeast of Brazil: Case study in the municipality of Exu. 61
33798208 2021
10
Genetic differentiation of geographic populations of Rattus tanezumi based on the mitochondrial Cytb gene. 61
33735257 2021
11
A new generation needle- and adjuvant-free trivalent plague vaccine utilizing adenovirus-5 nanoparticle platform. 61
33514747 2021
12
Host traits, identity, and ecological conditions predict consistent flea abundance and prevalence on free-living California ground squirrels. 61
33508332 2021
13
Comparison of the transmission efficiency and plague progression dynamics associated with two mechanisms by which fleas transmit Yersinia pestis. 61
33284863 2020
14
Antibody Opsonization Enhances Early Interactions between Yersinia pestis and Neutrophils in the Skin and Draining Lymph Node in a Mouse Model of Bubonic Plague. 61
33077628 2020
15
Plagues, pandemics and epidemics in Irish history prior to COVID-19 (coronavirus): what can we learn? 61
32404230 2020
16
COVID-19 Symptom-Related Google Searches and Local COVID-19 Incidence in Spain: Correlational Study. 61
33156803 2020
17
AI-based healthcare: a new dawn or apartheid revisited? 61
33362363 2020
18
What's eating you? human flea (Pulex irritans). 61
33465194 2020
19
Estimating the basic reproduction number for the 2015 bubonic plague outbreak in Nyimba district of Eastern Zambia. 61
33166354 2020
20
History through the eyes of a pandemic. 61
33009087 2020
21
The Recovery, Interpretation and Use of Ancient Pathogen Genomes. 61
33022266 2020
22
History through the eyes of a pandemic. 61
32969843 2020
23
An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial. 61
32807214 2020
24
Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model. 61
32756297 2020
25
India in the pandemic age. 61
32836356 2020
26
Let's emerge from the pandemic lockdown into a fairer academic world. 61
32693069 2020
27
Biovar-related differences apparent in the flea foregut colonization phenotype of distinct Yersinia pestis strains do not impact transmission efficiency. 61
32611387 2020
28
Rapid diagnostic tests for plague. 61
32597510 2020
29
A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity. 61
32560686 2020
30
The plague in Bologna in the year 1527. 61
32487796 2020
31
Salvation in a Time of Plague. 61
32449663 2020
32
The Bubonic Plague in San Francisco. 61
32427296 2020
33
Modeling the Justinianic Plague: Comparing hypothesized transmission routes. 61
32352988 2020
34
Performance of plague rapid diagnostic test compared to bacteriology: a retrospective analysis of the data collected in Madagascar. 61
32000692 2020
35
The "Scourge of the Renaissance". A Short Review About Treponema pallidum infection. 61
31625831 2020
36
Crystal structure of UDP-glucose pyrophosphorylase from Yersinia pestis, a potential therapeutic target against plague. 61
31475928 2019
37
Temperature Control of psaA Expression by PsaE and PsaF in Yersinia pestis. 61
31138630 2019
38
[Rapidly fatal septicemic plague secondary to undiagnosed primary bubonic plague: case report]. 61
31800948 2019
39
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination and diagnostics. 61
31252217 2019
40
Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics. 61
30940874 2019
41
Epidemiological characteristics of an urban plague epidemic in Madagascar, August-November, 2017: an outbreak report. 61
30930106 2019
42
Late-onset Vibrio vulnificus septicemia without cirrhosis. 61
31191157 2019
43
Zoonotic Semiotics: Plague Narratives and Vanishing Signs in Madagascar. 61
30811661 2019
44
Trends of Human Plague, Madagascar, 1998-2016. 61
30666930 2019
45
Human Neutrophil Isolation and Degranulation Responses to Yersinia pestis Infection. 61
31177440 2019
46
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine. 61
30467064 2019
47
Epidemiology of a bubonic plague outbreak in Glasgow, Scotland in 1900. 61
30800398 2019
48
Dispersal route of the Asian house rat (Rattus tanezumi) on mainland China: insights from microsatellite and mitochondrial DNA. 61
30669977 2019
49
Plague before the Pandemics: The Greek Medical Evidence for Bubonic Plague before the Sixth Century. 61
31303627 2019
50
Epidemiology of Plague: Problems with the Use of Mathematical Epidemiological Models in Plague Research and the Question of Transmission by Human Fleas and Lice. 61
31531149 2019

Variations for Bubonic Plague

Expression for Bubonic Plague

Search GEO for disease gene expression data for Bubonic Plague.

Pathways for Bubonic Plague

Pathways related to Bubonic Plague according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 TLR4 TLR2 SLC25A6 SLC25A5 SLC25A31 PLG
2
Show member pathways
11.69 TLR4 SLC25A6 SLC25A5 SLC25A31
3 10.58 SULT1A2 SULT1A1
4 10.37 SERPINF2 PLG
5 9.56 SULT1A2 SULT1A1

GO Terms for Bubonic Plague

Cellular components related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TLR4 TLR2 SERPINF2 PLG CCR5

Biological processes related to Bubonic Plague according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0050427 9.52 SULT1A2 SULT1A1
2 fibrinolysis GO:0042730 9.51 SERPINF2 PLG
3 sulfation GO:0051923 9.49 SULT1A2 SULT1A1
4 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.48 TLR4 TLR2
5 catecholamine metabolic process GO:0006584 9.46 SULT1A2 SULT1A1
6 ethanol catabolic process GO:0006068 9.43 SULT1A2 SULT1A1
7 I-kappaB phosphorylation GO:0007252 9.4 TLR4 TLR2
8 cellular response to lipoteichoic acid GO:0071223 9.37 TLR4 TLR2
9 negative regulation of fibrinolysis GO:0051918 9.32 SERPINF2 PLG
10 positive regulation of matrix metallopeptidase secretion GO:1904466 9.26 TLR4 TLR2
11 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.16 TLR4 TLR2
12 mitochondrial ATP transmembrane transport GO:1990544 9.13 SLC25A6 SLC25A5 SLC25A31
13 mitochondrial ADP transmembrane transport GO:0140021 8.8 SLC25A6 SLC25A5 SLC25A31

Molecular functions related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.35 VCAN TLR4 TLR2 SULT1A2 SULT1A1 SLC25A6
2 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.43 TLR4 TLR2
3 NAD(P)+ nucleosidase activity GO:0050135 9.4 TLR4 TLR2
4 aryl sulfotransferase activity GO:0004062 9.32 SULT1A2 SULT1A1
5 lipopolysaccharide receptor activity GO:0001875 9.26 TLR4 TLR2
6 flavonol 3-sulfotransferase activity GO:0047894 9.16 SULT1A2 SULT1A1
7 ATP transmembrane transporter activity GO:0005347 9.13 SLC25A6 SLC25A5 SLC25A31
8 ATP:ADP antiporter activity GO:0005471 8.8 SLC25A6 SLC25A5 SLC25A31

Sources for Bubonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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