MCID: BBN001
MIFTS: 43

Bubonic Plague

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Bubonic Plague

MalaCards integrated aliases for Bubonic Plague:

Name: Bubonic Plague 12 77 54 56 15 74
Black Death 12 77
Plague, Septicemic 74
Plague, Bubonic 77

Classifications:



External Ids:

Disease Ontology 12 DOID:10773
ICD9CM 36 020.0
MeSH 45 D010930
SNOMED-CT 69 50797007 58750007
ICD10 34 A20.0

Summaries for Bubonic Plague

Disease Ontology : 12 A plague that results in infection located in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has symptom enlarged, tender lymph nodes, has symptom fever, has symptom chills and has symptom prostration.

MalaCards based summary : Bubonic Plague, also known as black death, is related to plague and pneumonic plague, and has symptoms including fever, chills and enlarged. An important gene associated with Bubonic Plague is PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1), and among its related pathways/superpathways are Listeria monocytogenes entry into host cells and Jak/STAT Signaling Pathway Intracellular Regulation. The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and neutrophil, and related phenotype is behavior/neurological.

Wikipedia : 77 The Black Death, also known as the Great Plague, the Black Plague, or the Plague, was one of the most... more...

Related Diseases for Bubonic Plague

Diseases related to Bubonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 plague 33.2 CCR5 PLG
2 pneumonic plague 32.3 HOXA1 PLG
3 intraocular pressure quantitative trait locus 10.2
4 cholera 10.2
5 tularemia 10.2
6 pneumonia 10.2
7 nodular lymphocyte predominant hodgkin lymphoma 10.2
8 oligoarticular juvenile idiopathic arthritis 9.7 CCR5 PTPN2
9 immune deficiency disease 9.6
10 malaria 9.6
11 crohn's disease 9.6
12 variola major 9.6
13 crohn's colitis 9.6
14 influenza 9.6
15 smallpox 9.6

Graphical network of the top 20 diseases related to Bubonic Plague:



Diseases related to Bubonic Plague

Symptoms & Phenotypes for Bubonic Plague

Symptoms:

12
  • fever
  • chills
  • enlarged
  • prostration

MGI Mouse Phenotypes related to Bubonic Plague:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CCR5 CTSC HOXA1 MYLIP PTPN1 PTPN2

Drugs & Therapeutics for Bubonic Plague

Drugs for Bubonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
6
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
7 Antimalarials Phase 2
8 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 2
10 Antiparasitic Agents Phase 2
11 Topoisomerase Inhibitors Phase 2
12 Antiprotozoal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline

Search NIH Clinical Center for Bubonic Plague

Genetic Tests for Bubonic Plague

Anatomical Context for Bubonic Plague

MalaCards organs/tissues related to Bubonic Plague:

42
Lymph Node, Testes, Neutrophil, Lung, Skin, Colon, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Bubonic Plague:

20
Lymph Node Producing A Bubo

Publications for Bubonic Plague

Articles related to Bubonic Plague:

(show top 50) (show all 283)
# Title Authors Year
1
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine. ( 30467064 )
2019
2
Epidemiology of a bubonic plague outbreak in Glasgow, Scotland in 1900. ( 30800398 )
2019
3
Is Crohn Disease the price to pay today for having survived to the Black Death? ( 30893422 )
2019
4
Did Black Death strike sub-Saharan Africa? ( 30846576 )
2019
5
Fumigating the Hygienic Model City: Bubonic Plague and the Sulfurozador in Early-Twentieth-Century Buenos Aires. ( 29886876 )
2018
6
Human case of bubonic plague resulting from the bite of a wild Gunnison's prairie dog during translocation from a plague-endemic area. ( 29110441 )
2018
7
Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. ( 29884871 )
2018
8
Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague. ( 30374415 )
2018
9
The Knights Hospitaller of Rhodes and the Black Death of 1498: a poetic description of the plague. ( 30246775 )
2018
10
Stress, sex, and plague: Patterns of developmental stress and survival in pre- and post-Black Death London. ( 29071763 )
2018
11
Model-based analysis of an outbreak of bubonic plague in Cairo in 1801. ( 28637916 )
2017
12
Network theory may explain the vulnerability of medieval human settlements to the Black Death pandemic. ( 28262733 )
2017
13
Medical Care or Disciplinary Discourses? Preventive Measures against the Black Death in Late Medieval Paris: A Brief Review. ( 28435813 )
2017
14
The sex-selective impact of the Black Death and recurring plagues in the Southern Netherlands, 1349-1450. ( 28617987 )
2017
15
A Deadly Path: Bacterial Spread During Bubonic Plague. ( 26875618 )
2016
16
Adjunctive Corticosteroid Treatment Against Yersinia pestis Improves Bacterial Clearance, Immunopathology, and Survival in the Mouse Model of Bubonic Plague. ( 27402776 )
2016
17
ANCIENT DNA. How Europe exported the Black Death. ( 27126014 )
2016
18
Dissociation of Tissue Destruction and Bacterial Expansion during Bubonic Plague. ( 26484539 )
2015
19
Bacterial genomics: The Bronze Age: a time before bubonic plague. ( 26568068 )
2015
20
Travel history key to picking up on signs of bubonic plague. ( 26550675 )
2015
21
Comparison of Models for Bubonic Plague Reveals Unique Pathogen Adaptations to the Dermis. ( 25939507 )
2015
22
Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination. ( 26473734 )
2015
23
Setting the stage for medieval plague: Pre-black death trends in survival and mortality. ( 26174498 )
2015
24
New insights into how Yersinia pestis adapts to its mammalian host during bubonic plague. ( 24675805 )
2014
25
Health in post-Black Death London (1350-1538): age patterns of periosteal new bone formation in a post-epidemic population. ( 24740642 )
2014
26
Mortality risk and survival in the aftermath of the medieval Black Death. ( 24806459 )
2014
27
Host resistance, population structure and the long-term persistence of bubonic plague: contributions of a modelling approach in the Malagasy focus. ( 23675291 )
2013
28
Partial Retraction: yadBC of Yersinia pestis, a new virulence determinant for bubonic plague. ( 23335642 )
2013
29
Yersinia pestis biovar Microtus strain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques. ( 24225642 )
2013
30
Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague. ( 23982068 )
2013
31
Imaging early pathogenesis of bubonic plague: are neutrophils commandeered for lymphatic transport of bacteria? ( 24194541 )
2013
32
Mobility, mortality, and the middle ages: identification of migrant individuals in a 14th century black death cemetery population. ( 23225220 )
2013
33
Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. ( 23666009 )
2013
34
Strategy for sensitive and specific detection of Yersinia pestis in skeletons of the black death pandemic. ( 24069445 )
2013
35
A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in mice. ( 22537022 )
2012
36
Bacteriophage therapy of experimental bubonic plague in mice. ( 22782780 )
2012
37
Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis. ( 22496846 )
2012
38
Shutt up: bubonic plague and quarantine in early modern England. ( 22611587 )
2012
39
The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. ( 22927049 )
2012
40
Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague. ( 23285069 )
2012
41
A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague. ( 22403187 )
2012
42
Stature and frailty during the Black Death: the effect of stature on risks of epidemic mortality in London, A.D. 1348-1350. ( 24363485 )
2012
43
Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague. ( 21969002 )
2011
44
T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague. ( 21803090 )
2011
45
Banting Memorial Lecture 2010^. Type 2 diabetes as an 'infectious' disease: is this the Black Death of the 21st century? ( 21166840 )
2011
46
Banting Memorial Lecture: reply from Matthews and Matthews. Type2 diabetes as an 'infectious'disease: is this the Black Death of the 21st century? ( 21418089 )
2011
47
Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. ( 21876176 )
2011
48
The next generation of genetic investigations into the Black Death. ( 21903927 )
2011
49
A draft genome of Yersinia pestis from victims of the Black Death. ( 21993626 )
2011
50
Epidemic waves of the Black Death in the Byzantine Empire (1347-1453 AD). ( 22037442 )
2011

Variations for Bubonic Plague

Expression for Bubonic Plague

Search GEO for disease gene expression data for Bubonic Plague.

Pathways for Bubonic Plague

GO Terms for Bubonic Plague

Biological processes related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine dephosphorylation GO:0035335 9.37 PTPN1 PTPN2
2 insulin receptor signaling pathway GO:0008286 9.32 PTPN1 PTPN2
3 negative regulation of ERK1 and ERK2 cascade GO:0070373 9.26 PTPN1 PTPN2
4 negative regulation of insulin receptor signaling pathway GO:0046627 9.16 PTPN1 PTPN2
5 positive regulation of apoptotic signaling pathway GO:2001235 8.96 CTSC RPS3
6 regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 8.62 PTPN1 PTPN2

Molecular functions related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 CCR5 CTSC HOXA1 MYLIP PLG PTPN1
2 protein tyrosine phosphatase activity GO:0004725 9.43 PTPN1 PTPN2
3 chaperone binding GO:0051087 9.4 CTSC PLG
4 phosphoprotein phosphatase activity GO:0004721 9.37 PTPN1 PTPN2
5 protein kinase binding GO:0019901 9.33 PTPN1 PTPN2 RPS3
6 kinase binding GO:0019900 9.32 PLG RPS3
7 enzyme binding GO:0019899 9.13 PLG PTPN1 RPS3
8 receptor tyrosine kinase binding GO:0030971 8.62 PTPN1 PTPN2

Sources for Bubonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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