MCID: BBN001
MIFTS: 42

Bubonic Plague

Categories: Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Bubonic Plague

MalaCards integrated aliases for Bubonic Plague:

Name: Bubonic Plague 12 76 53 55 15 73
Black Death 12 76
Plague, Septicemic 73
Plague, Bubonic 76

Classifications:



External Ids:

Disease Ontology 12 DOID:10773
ICD10 33 A20.0
ICD9CM 35 020.0
MeSH 44 D010930
SNOMED-CT 68 50797007 58750007

Summaries for Bubonic Plague

Disease Ontology : 12 A plague that results in infection located in lymph node producing a bubo, which is an inflamed, necrotic, and hemorrhagic lymphoid tissue. The infection has symptom enlarged, tender lymph nodes, has symptom fever, has symptom chills and has symptom prostration.

MalaCards based summary : Bubonic Plague, also known as black death, is related to plague and pneumonic plague, and has symptoms including fever, chills and enlarged. An important gene associated with Bubonic Plague is PTPN1 (Protein Tyrosine Phosphatase, Non-Receptor Type 1), and among its related pathways/superpathways are Listeria monocytogenes entry into host cells and Jak/STAT Signaling Pathway Intracellular Regulation. The drugs Streptomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include lymph node, testes and neutrophil, and related phenotype is behavior/neurological.

Wikipedia : 76 The Black Death, also known as the Great Plague, the Black Plague, or simply the Plague, was one of the... more...

Related Diseases for Bubonic Plague

Diseases related to Bubonic Plague via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 plague 33.2 CCR5 PLG
2 pneumonic plague 32.4 HOXA1 PLG
3 adamantinoma of long bones 10.2
4 cholera 10.2
5 tularemia 10.2
6 pneumonia 10.2
7 oligoarticular juvenile idiopathic arthritis 9.8 CCR5 PTPN2
8 immune deficiency disease 9.6
9 malaria 9.6
10 smallpox 9.6

Graphical network of the top 20 diseases related to Bubonic Plague:



Diseases related to Bubonic Plague

Symptoms & Phenotypes for Bubonic Plague

Symptoms:

12
  • fever
  • chills
  • enlarged
  • prostration

MGI Mouse Phenotypes related to Bubonic Plague:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 CCR5 CTSC HOXA1 MYLIP PTPN1 PTPN2

Drugs & Therapeutics for Bubonic Plague

Drugs for Bubonic Plague (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Gentamicins Phase 2, Phase 3
5
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
6
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
7 Antiparasitic Agents Phase 2
8 Antiprotozoal Agents Phase 2
9 Cytochrome P-450 Enzyme Inhibitors Phase 2
10 Cytochrome P-450 CYP1A2 Inhibitors Phase 2
11 Antimalarials Phase 2
12 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment and Diagnosis of Plague Completed NCT00128466 Phase 2, Phase 3 gentamicin;streptomycin
2 A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans Unknown status NCT01243437 Phase 2 ciprofloxacin;doxyxcycline

Search NIH Clinical Center for Bubonic Plague

Genetic Tests for Bubonic Plague

Anatomical Context for Bubonic Plague

MalaCards organs/tissues related to Bubonic Plague:

41
Lymph Node, Testes, Neutrophil, Lung, Skin, Colon, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Bubonic Plague:

19
Lymph Node Producing A Bubo

Publications for Bubonic Plague

Articles related to Bubonic Plague:

(show top 50) (show all 280)
# Title Authors Year
1
Humoral and cellular immune correlates of protection against bubonic plague by a live Yersinia pseudotuberculosis vaccine. ( 30467064 )
2019
2
Fumigating the Hygienic Model City: Bubonic Plague and the Sulfurozador in Early-Twentieth-Century Buenos Aires. ( 29886876 )
2018
3
Human case of bubonic plague resulting from the bite of a wild Gunnison's prairie dog during translocation from a plague-endemic area. ( 29110441 )
2018
4
Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague. ( 29884871 )
2018
5
Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague. ( 30374415 )
2018
6
Stress, sex, and plague: Patterns of developmental stress and survival in pre- and post-Black Death London. ( 29071763 )
2018
7
The Knights Hospitaller of Rhodes and the Black Death of 1498: a poetic description of the plague. ( 30246775 )
2018
8
Model-based analysis of an outbreak of bubonic plague in Cairo in 1801. ( 28637916 )
2017
9
Network theory may explain the vulnerability of medieval human settlements to the Black Death pandemic. ( 28262733 )
2017
10
Medical Care or Disciplinary Discourses? Preventive Measures against the Black Death in Late Medieval Paris: A Brief Review. ( 28435813 )
2017
11
The sex-selective impact of the Black Death and recurring plagues in the Southern Netherlands, 1349-1450. ( 28617987 )
2017
12
A Deadly Path: Bacterial Spread During Bubonic Plague. ( 26875618 )
2016
13
Adjunctive Corticosteroid Treatment Against Yersinia pestis Improves Bacterial Clearance, Immunopathology, and Survival in the Mouse Model of Bubonic Plague. ( 27402776 )
2016
14
ANCIENT DNA. How Europe exported the Black Death. ( 27126014 )
2016
15
Dissociation of Tissue Destruction and Bacterial Expansion during Bubonic Plague. ( 26484539 )
2015
16
Bacterial genomics: The Bronze Age: a time before bubonic plague. ( 26568068 )
2015
17
Travel history key to picking up on signs of bubonic plague. ( 26550675 )
2015
18
Comparison of Models for Bubonic Plague Reveals Unique Pathogen Adaptations to the Dermis. ( 25939507 )
2015
19
Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination. ( 26473734 )
2015
20
Setting the stage for medieval plague: Pre-black death trends in survival and mortality. ( 26174498 )
2015
21
New insights into how Yersinia pestis adapts to its mammalian host during bubonic plague. ( 24675805 )
2014
22
Health in post-Black Death London (1350-1538): age patterns of periosteal new bone formation in a post-epidemic population. ( 24740642 )
2014
23
Mortality risk and survival in the aftermath of the medieval Black Death. ( 24806459 )
2014
24
Host resistance, population structure and the long-term persistence of bubonic plague: contributions of a modelling approach in the Malagasy focus. ( 23675291 )
2013
25
Partial Retraction: yadBC of Yersinia pestis, a new virulence determinant for bubonic plague. ( 23335642 )
2013
26
Yersinia pestis biovar Microtus strain 201, an avirulent strain to humans, provides protection against bubonic plague in rhesus macaques. ( 24225642 )
2013
27
Yersinia pestis subverts the dermal neutrophil response in a mouse model of bubonic plague. ( 23982068 )
2013
28
Imaging early pathogenesis of bubonic plague: are neutrophils commandeered for lymphatic transport of bacteria? ( 24194541 )
2013
29
Mobility, mortality, and the middle ages: identification of migrant individuals in a 14th century black death cemetery population. ( 23225220 )
2013
30
Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. ( 23666009 )
2013
31
Strategy for sensitive and specific detection of Yersinia pestis in skeletons of the black death pandemic. ( 24069445 )
2013
32
A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in mice. ( 22537022 )
2012
33
Bacteriophage therapy of experimental bubonic plague in mice. ( 22782780 )
2012
34
Imaging of bubonic plague dynamics by in vivo tracking of bioluminescent Yersinia pestis. ( 22496846 )
2012
35
Shutt up: bubonic plague and quarantine in early modern England. ( 22611587 )
2012
36
The Yfe and Feo transporters are involved in microaerobic growth and virulence of Yersinia pestis in bubonic plague. ( 22927049 )
2012
37
Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague. ( 23285069 )
2012
38
A Toll/interleukin (IL)-1 receptor domain protein from Yersinia pestis interacts with mammalian IL-1/Toll-like receptor pathways but does not play a central role in the virulence of Y. pestis in a mouse model of bubonic plague. ( 22403187 )
2012
39
Stature and frailty during the Black Death: the effect of stature on risks of epidemic mortality in London, A.D. 1348-1350. ( 24363485 )
2012
40
Role of the Yersinia pestis Ail protein in preventing a protective polymorphonuclear leukocyte response during bubonic plague. ( 21969002 )
2011
41
T cells play an essential role in anti-F1 mediated rapid protection against bubonic plague. ( 21803090 )
2011
42
Banting Memorial Lecture 2010^. Type 2 diabetes as an 'infectious' disease: is this the Black Death of the 21st century? ( 21166840 )
2011
43
Banting Memorial Lecture: reply from Matthews and Matthews. Type2 diabetes as an 'infectious'disease: is this the Black Death of the 21st century? ( 21418089 )
2011
44
Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. ( 21876176 )
2011
45
The next generation of genetic investigations into the Black Death. ( 21903927 )
2011
46
A draft genome of Yersinia pestis from victims of the Black Death. ( 21993626 )
2011
47
Epidemic waves of the Black Death in the Byzantine Empire (1347-1453 AD). ( 22037442 )
2011
48
Was the black death in India and China? ( 22080795 )
2011
49
Human anti-plague monoclonal antibodies protect mice from Yersinia pestis in a bubonic plague model. ( 20976274 )
2010
50
Paleoclimate and bubonic plague: a forewarning of future risk? ( 24576348 )
2010

Variations for Bubonic Plague

Expression for Bubonic Plague

Search GEO for disease gene expression data for Bubonic Plague.

Pathways for Bubonic Plague

GO Terms for Bubonic Plague

Biological processes related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine dephosphorylation GO:0035335 9.37 PTPN1 PTPN2
2 insulin receptor signaling pathway GO:0008286 9.32 PTPN1 PTPN2
3 negative regulation of ERK1 and ERK2 cascade GO:0070373 9.26 PTPN1 PTPN2
4 negative regulation of insulin receptor signaling pathway GO:0046627 9.16 PTPN1 PTPN2
5 positive regulation of apoptotic signaling pathway GO:2001235 8.96 CTSC RPS3
6 regulation of hepatocyte growth factor receptor signaling pathway GO:1902202 8.62 PTPN1 PTPN2

Molecular functions related to Bubonic Plague according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.86 CCR5 CTSC HOXA1 MYLIP PLG PTPN1
2 protein tyrosine phosphatase activity GO:0004725 9.43 PTPN1 PTPN2
3 chaperone binding GO:0051087 9.4 CTSC PLG
4 phosphoprotein phosphatase activity GO:0004721 9.37 PTPN1 PTPN2
5 protein kinase binding GO:0019901 9.33 PTPN1 PTPN2 RPS3
6 kinase binding GO:0019900 9.32 PLG RPS3
7 enzyme binding GO:0019899 9.13 PLG PTPN1 RPS3
8 receptor tyrosine kinase binding GO:0030971 8.62 PTPN1 PTPN2

Sources for Bubonic Plague

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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