MCID: BLL012
MIFTS: 37

Bullous Impetigo

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Bullous Impetigo

MalaCards integrated aliases for Bullous Impetigo:

Name: Bullous Impetigo 59 55 72

Characteristics:

Orphanet epidemiological data:

59
bullous impetigo
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

ICD10 via Orphanet 34 L01.0
UMLS via Orphanet 73 C0021100
Orphanet 59 ORPHA36237
UMLS 72 C0021100

Summaries for Bullous Impetigo

MalaCards based summary : Bullous Impetigo is related to ritter's disease and impetigo. An important gene associated with Bullous Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Pathways in cancer and Apoptotic cleavage of cellular proteins. The drugs Retapamulin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and testes, and related phenotypes are abnormal blistering of the skin and erythema

Wikipedia : 75 Bullous impetigo is a bacterial skin infection caused by Staphylococcus aureus that results in the... more...

Related Diseases for Bullous Impetigo

Diseases related to Bullous Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 ritter's disease 31.9 EDNRB EDNRA DSG1
2 impetigo 31.5 IL6 EDNRB DSG1 CALCA
3 pemphigus 30.9 DSG3 DSG1
4 pemphigus foliaceus 30.6 DSG3 DSG1
5 bullous pemphigoid 30.0 DSG3 DSG1
6 recessive dystrophic epidermolysis bullosa-generalized other 11.4
7 miliaria rubra 10.3
8 miliaria 10.3
9 skin disease 10.2
10 herpes simplex 10.2
11 superficial pemphigus 10.2
12 acute cholangitis 10.2 IL6 CALCA
13 herpetiform pemphigus 10.1 DSG3 DSG1
14 nodular goiter 10.1 IL6 CALCA
15 complex regional pain syndrome 10.1 IL6 CALCA
16 esophagitis 10.1 IL6 DSG1
17 bullous skin disease 10.1 DSG3 DSG1
18 bone resorption disease 10.1 IL6 CALCA
19 cellulitis 10.0 DSG3 DSG1
20 dermatitis, atopic 10.0
21 exanthem 10.0
22 penicillin allergy 10.0
23 endocarditis 10.0
24 bacterial infectious disease 10.0
25 toxic shock syndrome 10.0
26 dermatitis 10.0
27 chickenpox 10.0
28 neonatal herpes 10.0
29 pyogenic granuloma 10.0
30 congenital herpes simplex virus infection 10.0
31 streptococcal toxic-shock syndrome 10.0
32 bacterial pneumonia 10.0 IL6 CALCA
33 paraneoplastic pemphigus 10.0 DSG3 DSG1
34 subcorneal pustular dermatosis 10.0 DSG3 DSG1
35 migraine with or without aura 1 9.9 EDNRA CALCA
36 multiple endocrine neoplasia, type iib 9.8 EDNRB CALCA
37 autonomic nervous system disease 9.8 EDNRB CALCA
38 perinephritis 9.8 EDNRB EDNRA
39 scarlet fever 9.8 EDNRB EDNRA
40 radiation proctitis 9.8 EDNRB EDNRA
41 constipation 9.7 EDNRB CALCA
42 thyroid carcinoma, familial medullary 9.6 EDNRB CALCA
43 intestinal disease 9.6 IL6 EDNRB
44 thyroid cancer, nonmedullary, 2 9.5 EDNRB CALCA
45 commensal bacterial infectious disease 9.4 IL6 EDNRB DSG1
46 cystic kidney disease 9.4 EDNRB EDNRA
47 connective tissue disease 9.3 IL6 EDNRB EDNRA
48 autosomal dominant polycystic kidney disease 9.2 EDNRB EDNRA

Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to Bullous Impetigo

Symptoms & Phenotypes for Bullous Impetigo

Human phenotypes related to Bullous Impetigo:

59 32 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal blistering of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0008066
2 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
3 recurrent bacterial skin infections 59 32 hallmark (90%) Very frequent (99-80%) HP:0005406
4 pustule 59 32 hallmark (90%) Very frequent (99-80%) HP:0200039
5 glomerulopathy 59 32 occasional (7.5%) Occasional (29-5%) HP:0100820
6 abnormality of the lymphatic system 59 32 occasional (7.5%) Occasional (29-5%) HP:0100763
7 sepsis 59 32 occasional (7.5%) Occasional (29-5%) HP:0100806
8 septic arthritis 59 32 occasional (7.5%) Occasional (29-5%) HP:0003095

MGI Mouse Phenotypes related to Bullous Impetigo:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 DSG1 DSG3 EDNRA EDNRB IL6
2 digestive/alimentary MP:0005381 9.62 DSG3 EDNRA EDNRB IL6
3 respiratory system MP:0005388 9.46 DSG3 EDNRA EDNRB IL6
4 skeleton MP:0005390 9.35 DSG1 DSG3 EDNRA EDNRB IL6
5 vision/eye MP:0005391 9.02 DSG1 DSG3 EDNRA EDNRB IL6

Drugs & Therapeutics for Bullous Impetigo

Drugs for Bullous Impetigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Retapamulin Approved Phase 3 224452-66-8 6918462
2 Anti-Bacterial Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III 2 Arms, Multicenter, Randomised, Double-blind Study to Assess the Efficacy and Safety of Ozenoxacin 1% Cream Applied Twice Daily for 5 Days Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
2 A Phase III 3 Arms, Multicenter, Randomised, Investigator-blind Study to Assess the Efficacy and Safety of Ozenoxacin 1% Cream Applied Twice Daily for 5 Days Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream
3 Randomized, Double-Blind, Vehicle Controlled, Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Activity of Topical ATx201 GEL (2% and 4%) in Outpatients With Impetigo Completed NCT03429595 Phase 2 ATx201
4 A Phase II, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Doses of LTX-109 (1 % and 2 %) Versus Placebo in Impetigo Completed NCT01803035 Phase 2 LTX-109 1 %;LTX-109 2 %;Placebo gel

Search NIH Clinical Center for Bullous Impetigo

Genetic Tests for Bullous Impetigo

Anatomical Context for Bullous Impetigo

MalaCards organs/tissues related to Bullous Impetigo:

41
Skin, Breast, Testes

Publications for Bullous Impetigo

Articles related to Bullous Impetigo:

(show top 50) (show all 182)
# Title Authors PMID Year
1
[Primary cutaneous infections due to Staphylococcus and Streptococcus]. 9 38
18093494 2007
2
Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction. 9 38
17657525 2007
3
[Desmoglein, the target molecule in autoimmunity and infection]. 9 38
17075192 2006
4
Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. 9 38
15815014 2005
5
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. 9 38
11062541 2000
6
Toxin involvement in staphylococcal scalded skin syndrome. 9 38
9431380 1997
7
Topical Ozenoxacin Cream 1% for Impetigo: A Review 38
31334625 2019
8
Structures of a highly variable cell-wall anchored protein-encoding the spj gene from ST8/SCCmecIVl community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype. 38
31009089 2019
9
Localised bullous pemphigoid overlying knee arthroplasty: a diagnostic challenge. 38
30954955 2019
10
Neonatal Birthmarks: A Prospective Survey in 1000 Neonates. 38
30956996 2019
11
[Pemphigus vulgaris in pediatrics: A case report]. 38
30571809 2018
12
Skin Infections. 38
30115333 2018
13
Sweet Syndrome in Pediatrics. A case report. 38
30571826 2018
14
A C126R de novo Mutation in CYBB Leads to X-linked Chronic Granulomatous Disease With Recurrent Pneumonia and BCGitis. 38
30255005 2018
15
Bullous impetigo during interstitial pneumonitis. 38
29050448 2017
16
[Acute skin infections and their imitators in children : A photo quiz]. 38
28914333 2017
17
Anti-Interleukin-6 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to Anti-Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty-Five Patients. 38
27696756 2017
18
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. 38
28329529 2017
19
Common Skin Conditions in Children: Neonatal Skin Lesions. 38
28196316 2017
20
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. 38
27599660 2016
21
Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature. 38
29967859 2016
22
Staphylococcal bullous impetigo in a neonate. 38
27458596 2016
23
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. 38
27617460 2016
24
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. 38
26603272 2016
25
"EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern. 38
26821848 2016
26
C55 bacteriocin produced by ETB-plasmid positive Staphylococcus aureus strains is a key factor for competition with S. aureus strains. 38
26801833 2016
27
[A neonate with blisters on his upper legs]. 38
26860750 2016
28
Blistering Distal Dactylitis in an Adult. 38
25775614 2015
29
Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants. 38
25194957 2015
30
Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. 38
25172376 2014
31
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. 38
25298068 2014
32
Impetigo: diagnosis and treatment. 38
25250996 2014
33
Bullous impetigo. 38
24736928 2014
34
Blisters - an unusual effect during radiotherapy. 38
24158604 2013
35
Neonatal vesiculopustular eruption associated with transient myeloproliferative disorder: report of four cases. 38
23046498 2013
36
Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis. 38
23712060 2013
37
"Eczema coxsackium" and unusual cutaneous findings in an enterovirus outbreak. 38
23776120 2013
38
A rare case of woolly hair with unusual associations. 38
23984241 2013
39
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. 38
23111154 2013
40
Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities. 38
23505464 2013
41
Testicular nocardiosis accompanied by cutaneous lesions in an immunocompetent man. 38
23291688 2013
42
Recognizing pyoderma: more difficult than it may seem. 38
23182321 2013
43
Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains. 38
23078129 2012
44
The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward. 38
23168170 2012
45
Mucocutaneous manifestations of acquired hypoparathyroidism: An observational study. 38
23087872 2012
46
Bullous impetigo associated with Abiotrophia defectiva in an immunocompetent adult. 38
22493280 2012
47
Desmoglein as a target in skin disease and beyond. 38
22189787 2012
48
Outbreak of bullous impetigo caused by Staphylococcus aureus strains of phage type 3C/71 in a maternity ward linked to nasal carriage of a healthcare worker. 38
22378195 2012
49
Staphylococcus pseudintermedius exfoliative toxin EXI selectively digests canine desmoglein 1 and causes subcorneal clefts in canine epidermis. 38
21410798 2011
50
Staphylococcal infection mimicking child abuse: what is the differential diagnosis and appropriate evaluation? 38
21642794 2011

Variations for Bullous Impetigo

Expression for Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for Bullous Impetigo

GO Terms for Bullous Impetigo

Cellular components related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 DSG3 DSG1
2 desmosome GO:0030057 8.62 DSG3 DSG1

Biological processes related to Bullous Impetigo according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.5 EDNRB EDNRA CALCA
2 cornification GO:0070268 9.49 DSG3 DSG1
3 monocyte chemotaxis GO:0002548 9.48 IL6 CALCA
4 activation of adenylate cyclase activity GO:0007190 9.46 EDNRA CALCA
5 vasoconstriction GO:0042310 9.37 EDNRB EDNRA
6 negative regulation of bone resorption GO:0045779 9.26 IL6 CALCA
7 enteric nervous system development GO:0048484 9.16 EDNRB EDNRA
8 vasodilation GO:0042311 9.13 EDNRB
9 regulation of blood pressure GO:0008217 9.13 EDNRB EDNRA CALCA
10 response to pain GO:0048265 9.1 EDNRB
11 endothelin receptor signaling pathway GO:0086100 8.62 EDNRB EDNRA

Molecular functions related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Bullous Impetigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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