MCID: BLL012
MIFTS: 39

Bullous Impetigo

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Bullous Impetigo

MalaCards integrated aliases for Bullous Impetigo:

Name: Bullous Impetigo 58 54 71

Characteristics:

Orphanet epidemiological data:

58
bullous impetigo
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare infectious diseases


External Ids:

ICD10 via Orphanet 33 L01.0
UMLS via Orphanet 72 C0021100
Orphanet 58 ORPHA36237
UMLS 71 C0021100

Summaries for Bullous Impetigo

MalaCards based summary : Bullous Impetigo is related to pemphigus foliaceus and impetigo. An important gene associated with Bullous Impetigo is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Pathways in cancer and Lung fibrosis. The drugs Retapamulin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and testes, and related phenotypes are abnormal blistering of the skin and erythema

Wikipedia : 74 Bullous impetigo is a bacterial skin infection caused by Staphylococcus aureus that results in the... more...

Related Diseases for Bullous Impetigo

Diseases related to Bullous Impetigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 pemphigus foliaceus 30.8 DSG3 DSG1
2 impetigo 30.5 IL6 EDNRB EDNRA DSG3 DSG1 CALCA
3 pemphigus 30.3 IL6 DSG3 DSG1
4 skin disease 29.8 IL6 DSG3 DSG1
5 ritter's disease 29.6 EDNRB EDNRA DSG3 DSG1
6 toxic shock syndrome 29.6 IL6 EDNRA
7 bullous pemphigoid 29.4 DSG3 DSG1
8 recessive dystrophic epidermolysis bullosa-generalized other 11.4
9 miliaria rubra 10.3
10 miliaria 10.3
11 dermatitis, atopic 10.2
12 herpes simplex 10.2
13 chickenpox 10.2
14 superficial pemphigus 10.2
15 herpetiform pemphigus 10.2 DSG3 DSG1
16 tinea imbricata 10.2 DSG3 DSG1
17 iga pemphigus 10.2 DSG3 DSG1
18 pemphigoid gestationis 10.1 DSG3 DSG1
19 subcorneal pustular dermatosis 10.1 DSG3 DSG1
20 paraneoplastic pemphigus 10.1 DSG3 DSG1
21 vesiculobullous skin disease 10.1 DSG3 DSG1
22 bullous skin disease 10.1 DSG3 DSG1
23 naxos disease 10.1 DSG3 DSG1
24 benign chronic pemphigus 10.1 DSG3 DSG1
25 darier-white disease 10.1 DSG3 DSG1
26 hidradenitis suppurativa 10.1 DSG3 DSG1
27 hidradenitis 10.1 DSG3 DSG1
28 pemphigus vulgaris, familial 10.1 DSG3 DSG1
29 familial woolly hair syndrome 10.1 DSG3 DSG1
30 palmoplantar keratosis 10.1 DSG3 DSG1
31 exanthem 10.0
32 penicillin allergy 10.0
33 endocarditis 10.0
34 bacterial infectious disease 10.0
35 ecthyma 10.0
36 dermatitis 10.0
37 scabies 10.0
38 eczema herpeticum 10.0
39 neonatal herpes 10.0
40 pyogenic granuloma 10.0
41 streptococcal toxic-shock syndrome 10.0
42 gorham's disease 10.0 IL6 CALCA
43 headache 10.0 EDNRA CALCA
44 acute cholangitis 10.0 IL6 CALCA
45 osteitis fibrosa 10.0 IL6 CALCA
46 polyradiculopathy 10.0 IL6 CALCA
47 erysipelas 10.0 IL6 CALCA
48 decubitus ulcer 10.0 IL6 CALCA
49 burning mouth syndrome 10.0 IL6 CALCA
50 bone deterioration disease 10.0 IL6 CALCA

Graphical network of the top 20 diseases related to Bullous Impetigo:



Diseases related to Bullous Impetigo

Symptoms & Phenotypes for Bullous Impetigo

Human phenotypes related to Bullous Impetigo:

58 31 (show all 8)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal blistering of the skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0008066
2 erythema 58 31 hallmark (90%) Very frequent (99-80%) HP:0010783
3 recurrent bacterial skin infections 58 31 hallmark (90%) Very frequent (99-80%) HP:0005406
4 pustule 58 31 hallmark (90%) Very frequent (99-80%) HP:0200039
5 glomerulopathy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100820
6 abnormality of the lymphatic system 58 31 occasional (7.5%) Occasional (29-5%) HP:0100763
7 sepsis 58 31 occasional (7.5%) Occasional (29-5%) HP:0100806
8 septic arthritis 58 31 occasional (7.5%) Occasional (29-5%) HP:0003095

MGI Mouse Phenotypes related to Bullous Impetigo:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.65 DSG1 DSG3 EDNRA EDNRB IL6
2 digestive/alimentary MP:0005381 9.62 DSG3 EDNRA EDNRB IL6
3 respiratory system MP:0005388 9.46 DSG3 EDNRA EDNRB IL6
4 skeleton MP:0005390 9.35 DSG1 DSG3 EDNRA EDNRB IL6
5 vision/eye MP:0005391 9.02 DSG1 DSG3 EDNRA EDNRB IL6

Drugs & Therapeutics for Bullous Impetigo

Drugs for Bullous Impetigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Retapamulin Approved Phase 3 224452-66-8 6918462
2 Anti-Bacterial Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase III 2 Arms, Multicenter, Randomised, Double-blind Study to Assess the Efficacy and Safety of Ozenoxacin 1% Cream Applied Twice Daily for 5 Days Versus Placebo in the Treatment of Patients With Impetigo Completed NCT02090764 Phase 3 Ozenoxacin;Placebo
2 A Phase III 3 Arms, Multicenter, Randomised, Investigator-blind Study to Assess the Efficacy and Safety of Ozenoxacin 1% Cream Applied Twice Daily for 5 Days Versus Placebo in the Treatment of Patients With Impetigo Completed NCT01397461 Phase 3 ozenoxacin placebo;retapamulin 1% ointment;ozenoxacin 1% cream
3 Randomized, Double-Blind, Vehicle Controlled, Phase 2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Activity of Topical ATx201 GEL (2% and 4%) in Outpatients With Impetigo Completed NCT03429595 Phase 2 ATx201
4 A Phase II, Randomised, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Doses of LTX-109 (1 % and 2 %) Versus Placebo in Impetigo Completed NCT01803035 Phase 2 LTX-109 1 %;LTX-109 2 %;Placebo gel

Search NIH Clinical Center for Bullous Impetigo

Genetic Tests for Bullous Impetigo

Anatomical Context for Bullous Impetigo

MalaCards organs/tissues related to Bullous Impetigo:

40
Skin, Breast, Testes

Publications for Bullous Impetigo

Articles related to Bullous Impetigo:

(show top 50) (show all 185)
# Title Authors PMID Year
1
[Primary cutaneous infections due to Staphylococcus and Streptococcus]. 61 54
18093494 2007
2
Imaging and force spectroscopy on desmoglein 1 using atomic force microscopy reveal multivalent Ca(2+)-dependent, low-affinity trans-interaction. 61 54
17657525 2007
3
[Desmoglein, the target molecule in autoimmunity and infection]. 54 61
17075192 2006
4
Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins. 54 61
15815014 2005
5
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1. 54 61
11062541 2000
6
Toxin involvement in staphylococcal scalded skin syndrome. 54 61
9431380 1997
7
Bullous impetigo masquerading as pemphigus foliaceus in an adult patient. 61
32382637 2020
8
Ozenoxacin, a New Effective and Safe Topical Treatment for Impetigo in Children and Adolescents. 61
31958794 2020
9
Disseminated bullous impetigo and atopic dermatitis: Case series and literature review. 61
31755570 2020
10
Topical Ozenoxacin Cream 1% for Impetigo: A Review 61
31334625 2019
11
Structures of a highly variable cell-wall anchored protein-encoding the spj gene from ST8/SCCmecIVl community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA/J) isolated from 2003 onwards: An indicator of a strongly invasive pathotype. 61
31009089 2019
12
Localised bullous pemphigoid overlying knee arthroplasty: a diagnostic challenge. 61
30954955 2019
13
Neonatal Birthmarks: A Prospective Survey in 1000 Neonates. 61
30956996 2019
14
[Pemphigus vulgaris in pediatrics: A case report]. 61
30571809 2018
15
Skin Infections. 61
30115333 2018
16
Sweet Syndrome in Pediatrics. A case report. 61
30571826 2018
17
A C126R de novo Mutation in CYBB Leads to X-linked Chronic Granulomatous Disease With Recurrent Pneumonia and BCGitis. 61
30255005 2018
18
Bullous impetigo during interstitial pneumonitis. 61
29050448 2017
19
[Acute skin infections and their imitators in children : A photo quiz]. 61
28914333 2017
20
Anti-Interleukin-6 Receptor Tocilizumab for Severe Juvenile Idiopathic Arthritis-Associated Uveitis Refractory to Anti-Tumor Necrosis Factor Therapy: A Multicenter Study of Twenty-Five Patients. 61
27696756 2017
21
Concurrent pyogenic granuloma and bullous impetigo of a pregnant woman's finger. 61
28329529 2017
22
Common Skin Conditions in Children: Neonatal Skin Lesions. 61
28196316 2017
23
Bullous Impetigo Rapid Diagnostic and Therapeutic Quiz: A Model for Assessing Basic Dermatology Knowledge of Primary Care Providers. 61
27599660 2016
24
Staphylococcal Scalded Skin Syndrome in Child. A Case Report and a Review from Literature. 61
29967859 2016
25
Staphylococcal bullous impetigo in a neonate. 61
27458596 2016
26
Bullous impetigo and pregnancy: Case report and review of blistering conditions in pregnancy. 61
27617460 2016
27
Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome. 61
26603272 2016
28
"EB, or Not EB?" Neonatal Desquamative Impetigo in a Degloving Pattern. 61
26821848 2016
29
C55 bacteriocin produced by ETB-plasmid positive Staphylococcus aureus strains is a key factor for competition with S. aureus strains. 61
26801833 2016
30
[A neonate with blisters on his upper legs]. 61
26860750 2016
31
Blistering Distal Dactylitis in an Adult. 61
25775614 2015
32
Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants. 61
25194957 2015
33
Short-course oral co-trimoxazole versus intramuscular benzathine benzylpenicillin for impetigo in a highly endemic region: an open-label, randomised, controlled, non-inferiority trial. 61
25172376 2014
34
Value of serum procalcitonin and interleukin-6 in patients with bullous impetigo and staphylococcal scalded skin syndrome. 61
25298068 2014
35
Impetigo: diagnosis and treatment. 61
25250996 2014
36
Bullous impetigo. 61
24736928 2014
37
Blisters - an unusual effect during radiotherapy. 61
24158604 2013
38
Neonatal vesiculopustular eruption associated with transient myeloproliferative disorder: report of four cases. 61
23046498 2013
39
Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis. 61
23712060 2013
40
A rare case of woolly hair with unusual associations. 61
23984241 2013
41
"Eczema coxsackium" and unusual cutaneous findings in an enterovirus outbreak. 61
23776120 2013
42
Paediatric bullous dermatoses. Linear immunoglobulin A (IgA) dermatosis. Bullous impetigo. Bullous insect bite reaction. Neonatal Herpes simplex virus (HSV) infection. 61
23111154 2013
43
Subpopulations of Staphylococcus aureus clonal complex 121 are associated with distinct clinical entities. 61
23505464 2013
44
Testicular nocardiosis accompanied by cutaneous lesions in an immunocompetent man. 61
23291688 2013
45
Recognizing pyoderma: more difficult than it may seem. 61
23182321 2013
46
Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains. 61
23078129 2012
47
The use of typing methods and infection prevention measures to control a bullous impetigo outbreak on a neonatal ward. 61
23168170 2012
48
Mucocutaneous manifestations of acquired hypoparathyroidism: An observational study. 61
23087872 2012
49
Bullous impetigo associated with Abiotrophia defectiva in an immunocompetent adult. 61
22493280 2012
50
Desmoglein as a target in skin disease and beyond. 61
22189787 2012

Variations for Bullous Impetigo

Expression for Bullous Impetigo

Search GEO for disease gene expression data for Bullous Impetigo.

Pathways for Bullous Impetigo

Pathways related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.27 IL6 EDNRB EDNRA
2 11.12 IL6 CALCA
3 10.98 EDNRB EDNRA
4 10.81 IL6 CALCA
5 10.43 EDNRB EDNRA
6 10.33 EDNRB EDNRA CALCA

GO Terms for Bullous Impetigo

Cellular components related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.46 IL6 EDNRB EDNRA CALCA
2 cornified envelope GO:0001533 8.96 DSG3 DSG1
3 desmosome GO:0030057 8.62 DSG3 DSG1

Biological processes related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 monocyte chemotaxis GO:0002548 9.48 IL6 CALCA
2 activation of adenylate cyclase activity GO:0007190 9.46 EDNRA CALCA
3 vasodilation GO:0042311 9.43 EDNRB CALCA
4 response to pain GO:0048265 9.4 EDNRB CALCA
5 vasoconstriction GO:0042310 9.37 EDNRB EDNRA
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.33 EDNRB EDNRA CALCA
7 negative regulation of bone resorption GO:0045779 9.32 IL6 CALCA
8 enteric nervous system development GO:0048484 9.26 EDNRB EDNRA
9 endothelin receptor signaling pathway GO:0086100 8.96 EDNRB EDNRA
10 regulation of blood pressure GO:0008217 8.8 EDNRB EDNRA CALCA

Molecular functions related to Bullous Impetigo according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endothelin receptor activity GO:0004962 8.62 EDNRB EDNRA

Sources for Bullous Impetigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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