Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 56 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD9CM 36 371.23
NCIt 51 C26970
SNOMED-CT 69 57207003
ICD10 34 H18.1
UMLS 74 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to keratopathy and cataract, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Pharmaceutical Solutions and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and skin, and related phenotypes are cardiovascular system and craniofacial

Wikipedia : 77 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 keratopathy 31.2 FBN1 IL1A NID1 TGFB2 TNC
2 cataract 10.4
3 corneal dystrophy, fuchs endothelial, 1 10.3
4 fuchs' endothelial dystrophy 10.3
5 stiff skin syndrome 10.3 FBN1 TGFB2
6 loeys-dietz syndrome 3 10.2 FBN1 TGFB2
7 corneal dystrophy, posterior polymorphous, 3 10.2 BMP4 TGFB2
8 char syndrome 10.2 BMP4 FBN1
9 cryptogenic organizing pneumonia 10.2 CXCL8 TNC
10 keratitis, hereditary 10.2
11 keratoconus 10.2
12 corneal disease 10.2
13 leukoregulin 10.2 CXCL8 IL1A
14 scabies 10.2 CXCL8 IL1A
15 sebaceous gland disease 10.1 CXCL8 IL1A
16 radiculopathy 10.1 CXCL8 IL1A
17 macular holes 10.1 CXCL8 TGFB2
18 pulpitis 10.1 CXCL8 IL1A
19 oral candidiasis 10.1 CXCL8 IL1A
20 astigmatism 10.1
21 macular retinal edema 10.1
22 herpes simplex 10.1
23 loeys-dietz syndrome 1 10.1 FBN1 TGFB2
24 synovial chondromatosis 10.1 BMP2 BMP4
25 fibrochondrogenesis 10.1 BMP2 BMP4
26 osseous heteroplasia, progressive 10.1 BMP2 BMP4
27 bacterial sepsis 10.0 CXCL8 SELE
28 osteochondroma 10.0 BMP2 TGFB2
29 pulmonary hypertension, primary, 1 10.0 BMP2 FBN1
30 otosclerosis 10.0 BMP2 BMP4
31 aniridia 1 9.9
32 macular dystrophy, dominant cystoid 9.9
33 corneal endothelial dystrophy 9.9
34 insulin-like growth factor i 9.9
35 werner syndrome 9.9
36 open-angle glaucoma 9.9
37 corneal edema 9.9
38 myopia 9.9
39 corneal ulcer 9.9
40 refractive error 9.9
41 cytokine deficiency 9.9
42 farsightedness 9.9
43 endotheliitis 9.9
44 essential iris atrophy 9.9
45 contact dermatitis 9.9 CXCL8 IL1A SELE
46 proteasome-associated autoinflammatory syndrome 1 9.9 CXCL8 IL1A SELE
47 pilomatrixoma 9.9 BMP2 BMP4
48 bacterial vaginosis 9.9 CXCL8 IL1A
49 hydrarthrosis 9.9 AQP3 MIP
50 skin disease 9.9 CXCL8 IL1A SELE

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 AQP3 BMP2 BMP4 FBN1 IL1A NID1
2 craniofacial MP:0005382 9.65 AQP3 BMP2 BMP4 FBN1 TGFB2
3 homeostasis/metabolism MP:0005376 9.56 AQP3 BMP2 BMP4 FBN1 IL1A SELE
4 hearing/vestibular/ear MP:0005377 9.55 AQP3 BMP2 BMP4 TGFB2 TNC
5 vision/eye MP:0005391 9.1 AQP3 BMP4 MIP NID1 SELE TGFB2

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3,Phase 2,Not Applicable
2 Ophthalmic Solutions Phase 3
3
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
4
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
5
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
6
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
7
Fluorometholone Approved, Investigational Phase 2,Not Applicable 426-13-1 9878
8
Bevacizumab Approved, Investigational Phase 2 216974-75-3
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Anesthetics Phase 2
11 Hormones Phase 2,Not Applicable
12 Hormone Antagonists Phase 2,Not Applicable
13 Autonomic Agents Phase 2,Not Applicable
14 Antiemetics Phase 2,Not Applicable
15 Methylprednisolone Acetate Phase 2
16 glucocorticoids Phase 2,Not Applicable
17 Gastrointestinal Agents Phase 2,Not Applicable
18 Anti-Allergic Agents Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
20 Antineoplastic Agents, Hormonal Phase 2,Not Applicable
21 Peripheral Nervous System Agents Phase 2,Not Applicable
22 Protective Agents Phase 2
23 Prednisolone acetate Phase 2
24 Anti-Inflammatory Agents Phase 2,Not Applicable
25 Neuroprotective Agents Phase 2
26 Endothelial Growth Factors Phase 2
27 Angiogenesis Modulating Agents Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Mitogens Phase 2
30 Antineoplastic Agents, Immunological Phase 2
31
Dipivefrin Approved Not Applicable 52365-63-6 3105
32
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
33
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 83-88-5 493570
34 Photosensitizing Agents Not Applicable
35 Dermatologic Agents Not Applicable
36 Vitamin B Complex Not Applicable
37 Vitamins Not Applicable
38 Trace Elements Not Applicable
39 Micronutrients Not Applicable
40 Vitamin B2 Not Applicable
41 Folate Not Applicable
42 Nutrients Not Applicable
43 Vitamin B9 Not Applicable
44 Alkylating Agents Not Applicable
45 Anti-Bacterial Agents Not Applicable
46 Antibiotics, Antitubercular Not Applicable
47 Nucleic Acid Synthesis Inhibitors Not Applicable
48 Mitomycins Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Active, not recruiting NCT03248037 Phase 3 Netarsudil;Placebo
2 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
3 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
4 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
5 Corneal Transplantation Guided by OCT RESCAN Unknown status NCT02736877 Not Applicable
6 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
7 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
8 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
9 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
10 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
11 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308 Not Applicable
12 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274 Not Applicable
13 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Not Applicable Mitomycin
14 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
15 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Not Applicable Salt solution
16 Study of Endothelial Keratoplasty Outcomes Completed NCT00800111 Not Applicable
17 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
18 The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation Recruiting NCT03763721 Not Applicable
19 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Not Applicable Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

42
Endothelial, Eye, Skin, Testes

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 287)
# Title Authors Year
1
Decreased epithelial to corneal thickness ratio in healthy fellow eyes of patients with unilateral bullous keratopathy. ( 31000511 )
2019
2
Different graft thicknesses after Descemet stripping endothelial keratoplasty for bullous keratopathy in the two eyes of the same patient. ( 30881147 )
2019
3
Triple procedure for pseudophakic bullous keratopathy in complicated cataract surgery: Glued IOL with single-pass four-throw pupilloplasty with pre-Descemet's endothelial keratoplasty. ( 30819560 )
2019
4
Effect of topical steroid instillation on central corneal thickness in eyes with bullous keratopathy. ( 30783940 )
2019
5
Cytokine Levels in the Aqueous Humor Are Associated With Corneal Thickness in Eyes With Bullous Keratopathy. ( 30316668 )
2019
6
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2019
7
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260153 )
2018
8
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260152 )
2018
9
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30231219 )
2018
10
Sustainability of Pain Relief After Corneal Collagen Cross-Linking in Eyes With Bullous Keratopathy. ( 29993202 )
2018
11
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
12
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. ( 29766356 )
2018
13
Glued intraocular lens with descemet stripping endothelial keratoplasty in aphakic bullous keratopathy. ( 29692490 )
2018
14
Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support. ( 29681843 )
2018
15
Bilateral bullous keratopathy secondary to melting keratitis in a Suri alpaca (Vicugna pacos). ( 29636928 )
2018
16
Painless bilateral bullous keratopathy. ( 29573998 )
2018
17
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. ( 29539291 )
2018
18
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. ( 29534662 )
2018
19
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
20
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
21
Pseudophakic bullous keratopathy. ( 29450379 )
2017
22
Regulatory Compliant Tissue-Engineered Human Corneal Endothelial Grafts Restore Corneal Function of Rabbits with Bullous Keratopathy. ( 29074873 )
2017
23
Young donor-graft assisted endothelial keratoplasty (PDEK/DMEK) with epithelial debridement for chronic pseudophakic bullous keratopathy. ( 28985815 )
2017
24
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
25
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
26
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. ( 27820951 )
2016
27
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
28
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
29
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
30
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
31
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
32
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. ( 26555584 )
2016
33
Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for bullous keratopathy. ( 26541104 )
2016
34
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. ( 26286755 )
2016
35
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). ( 25959108 )
2016
36
Occult Descemet's membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy. ( 29018686 )
2015
37
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. ( 26509766 )
2015
38
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. ( 26509077 )
2015
39
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. ( 26491241 )
2015
40
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. ( 26245501 )
2015
41
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. ( 25609910 )
2015
42
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. ( 25586624 )
2015
43
Treatment of bullous keratopathy with corneal collagen cross-linking in two dogs. ( 24373539 )
2015
44
Use of amniotic membrane in bullous keratopathy palliative care. ( 25870682 )
2014
45
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. ( 25627186 )
2014
46
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy. ( 25484904 )
2014
47
Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. ( 25088633 )
2014
48
Re: Arora et al.: Role of corneal collagen cross-linking in pseudophakic bullous keratopathy: a clinicopathological study (Ophthalmology 2013;120:2413-8). ( 25015213 )
2014
49
Three-year outcome of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. ( 24915015 )
2014
50
Regeneration of corneal endothelial cells following keratoplasty in rats with bullous keratopathy. ( 24883013 )
2014

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2
2
Show member pathways
13.09 BMP2 BMP4 CXCL8 IL1A TGFB2
3
Show member pathways
12.81 BMP2 BMP4 FBN1 TGFB2 TNC
4 12.63 BMP2 BMP4 CXCL8 TGFB2
5
Show member pathways
12.47 BMP2 BMP4 IL1A TGFB2
6
Show member pathways
12.09 BMP2 BMP4 FBN1 NID1 TGFB2 TNC
7
Show member pathways
12.03 CXCL8 FBN1 IL1A TNC
8 11.96 CXCL8 IL1A TGFB2
9 11.93 BMP2 BMP4 TGFB2
10
Show member pathways
11.93 BMP2 BMP4 CXCL8 IL1A TGFB2
11 11.88 BMP4 IL1A SELE
12 11.86 BMP2 BMP4 TGFB2
13
Show member pathways
11.78 BMP2 BMP4 CXCL8 IL1A TGFB2
14 11.74 BMP2 CXCL8 IL1A
15 11.65 CXCL8 IL1A TGFB2
16 11.64 BMP2 BMP4 TGFB2
17 11.56 CXCL8 IL1A SELE TGFB2
18 11.5 BMP2 BMP4 TGFB2
19
Show member pathways
11.45 CXCL8 IL1A SELE
20 11.37 CXCL8 SELE TGFB2
21
Show member pathways
11.32 BMP2 BMP4 FBN1 TGFB2
22 11.3 CXCL8 SELE TGFB2
23 11.22 SELE TNC
24 11.01 BMP2 BMP4
25 10.94 BMP2 BMP4 CXCL8 IL1A
26 10.93 BMP2 BMP4
27 10.07 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 BMP2 BMP4 CXCL8 FBN1 IL1A NID1
2 collagen-containing extracellular matrix GO:0062023 9.46 FBN1 NID1 TGFB2 TNC
3 basement membrane GO:0005604 9.43 FBN1 NID1 TNC
4 extracellular space GO:0005615 9.23 BMP2 BMP4 CXCL8 FBN1 IL1A SELE

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.94 BMP2 BMP4 IL1A TNC
2 inflammatory response GO:0006954 9.92 BMP2 CXCL8 IL1A SELE
3 negative regulation of gene expression GO:0010629 9.87 BMP2 BMP4 TGFB2
4 angiogenesis GO:0001525 9.86 BMP4 CXCL8 TGFB2
5 cellular protein metabolic process GO:0044267 9.85 BMP4 FBN1 TNC
6 extracellular matrix organization GO:0030198 9.85 FBN1 NID1 TNC
7 heart development GO:0007507 9.85 BMP2 BMP4 FBN1 TGFB2
8 negative regulation of cell proliferation GO:0008285 9.8 BMP2 BMP4 CXCL8 IL1A TGFB2
9 kidney development GO:0001822 9.79 BMP4 FBN1 TGFB2
10 osteoblast differentiation GO:0001649 9.77 BMP2 BMP4 TNC
11 cell development GO:0048468 9.71 BMP2 BMP4 TGFB2
12 branching involved in ureteric bud morphogenesis GO:0001658 9.7 BMP2 BMP4
13 regulation of MAPK cascade GO:0043408 9.7 BMP2 BMP4 TGFB2
14 chondrocyte differentiation GO:0002062 9.69 BMP2 BMP4
15 positive regulation of protein secretion GO:0050714 9.69 IL1A TGFB2
16 SMAD protein signal transduction GO:0060395 9.69 BMP2 BMP4 TGFB2
17 epithelial to mesenchymal transition GO:0001837 9.68 BMP2 TGFB2
18 cellular response to BMP stimulus GO:0071773 9.68 BMP2 BMP4
19 metanephros development GO:0001656 9.68 BMP4 FBN1
20 positive regulation of bone mineralization GO:0030501 9.67 BMP2 BMP4
21 telencephalon development GO:0021537 9.67 BMP2 BMP4
22 odontogenesis of dentin-containing tooth GO:0042475 9.67 BMP2 BMP4 TNC
23 outflow tract septum morphogenesis GO:0003148 9.66 BMP4 TGFB2
24 cardiac muscle cell differentiation GO:0055007 9.66 BMP2 BMP4
25 water transport GO:0006833 9.65 AQP3 MIP
26 embryonic digestive tract development GO:0048566 9.65 CXCL8 TGFB2
27 endocardial cushion morphogenesis GO:0003203 9.65 BMP2 TGFB2
28 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.65 BMP2 BMP4 TGFB2
29 positive regulation of cartilage development GO:0061036 9.64 BMP2 BMP4
30 cardiac right ventricle morphogenesis GO:0003215 9.63 BMP4 TGFB2
31 pulmonary valve morphogenesis GO:0003184 9.63 BMP4 TGFB2
32 positive regulation of epithelial to mesenchymal transition GO:0010718 9.63 BMP2 BMP4 TGFB2
33 skeletal system development GO:0001501 9.62 BMP2 BMP4 FBN1 TGFB2
34 cardiac epithelial to mesenchymal transition GO:0060317 9.61 BMP2 TGFB2
35 pathway-restricted SMAD protein phosphorylation GO:0060389 9.61 BMP2 TGFB2
36 atrioventricular valve morphogenesis GO:0003181 9.6 BMP2 TGFB2
37 membranous septum morphogenesis GO:0003149 9.58 BMP4 TGFB2
38 pharyngeal arch artery morphogenesis GO:0061626 9.58 BMP4 TGFB2
39 telencephalon regionalization GO:0021978 9.57 BMP2 BMP4
40 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.56 BMP2 BMP4
41 odontogenesis GO:0042476 9.54 AQP3 BMP4 TGFB2
42 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.43 BMP2 BMP4
43 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.33 BMP2 BMP4 TGFB2
44 BMP signaling pathway involved in heart induction GO:0003130 9.26 BMP2 BMP4
45 positive regulation of ossification GO:0045778 9.13 BMP2 BMP4 TGFB2
46 regulation of signaling receptor activity GO:0010469 9.1 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 BMP2 BMP4 TGFB2
2 extracellular matrix structural constituent GO:0005201 9.5 FBN1 NID1 TNC
3 channel activity GO:0015267 9.43 AQP3 MIP
4 water channel activity GO:0015250 9.37 AQP3 MIP
5 co-receptor binding GO:0039706 9.26 BMP2 BMP4
6 BMP receptor binding GO:0070700 9.16 BMP2 BMP4
7 transforming growth factor beta receptor binding GO:0005160 9.13 BMP2 BMP4 TGFB2
8 cytokine activity GO:0005125 9.02 BMP2 BMP4 CXCL8 IL1A TGFB2

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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