MCID: BLL004
MIFTS: 47

Bullous Keratopathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 54 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD9CM 34 371.23
NCIt 50 C26970
SNOMED-CT 67 193815002
ICD10 32 H18.1
UMLS 70 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to corneal disease and keratopathy, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Anesthetics and Riboflavin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and skin, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 73 Bullous keratopathy, also known as pseudophakic bullous keratopathy (PBK), is a pathological condition... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 corneal disease 30.5 TGFB2 IL1A DCN CXCL8
2 keratopathy 30.2 TGFB3 TGFB2 NID1 ITGB1 IL1A IGF1
3 hydrops, lactic acidosis, and sideroblastic anemia 30.2 MIP AQP4 AQP1
4 intraocular pressure quantitative trait locus 30.1 TGFB2 MIP FBN1 BMP4 AQP4 AQP1
5 uveitis 30.1 TGFB2 IL1A CXCL8
6 retinal detachment 29.9 TGFB2 TGFB1 IGF1 CXCL8
7 cataract 29.7 TGFB3 TGFB2 MIP IGF1 FBN1 CXCL8
8 myopia 29.7 TGFB2 TGFB1 IGF1 FBN1 DCN
9 open-angle glaucoma 29.6 TGFB2 TGFB1 IL1A FBN1 BMP4 AQP1
10 corneal edema 10.7
11 macular retinal edema 10.5
12 keratitis, hereditary 10.5
13 astigmatism 10.5
14 fuchs' endothelial dystrophy 10.5
15 corneal dystrophy, fuchs endothelial, 1 10.4
16 ifap syndrome 2 10.4
17 keratoconus 10.4
18 macular degeneration, age-related, 1 10.3
19 tricuspid valve prolapse 10.3 TGFB3 TGFB2 FBN1
20 loeys-dietz syndrome 5 10.3 TGFB3 TGFB2 FBN1
21 loeys-dietz syndrome 10.3 TGFB3 TGFB2 FBN1
22 heritable thoracic aortic disease 10.3 TGFB3 TGFB2 FBN1
23 aortic disease 10.3 TGFB3 TGFB2 FBN1
24 loeys-dietz syndrome 3 10.3 TGFB3 TGFB2 FBN1
25 loeys-dietz syndrome 4 10.3 TGFB3 TGFB2 FBN1
26 corneal dystrophy 10.3
27 refractive error 10.3
28 loeys-dietz syndrome 1 10.3 TGFB3 TGFB2 FBN1
29 stiff skin syndrome 10.2 TGFB2 TGFB1 FBN1
30 tracheal stenosis 10.2 TGFB3 TGFB1 FBN1
31 fuchs' heterochromic uveitis 10.2 TGFB2 CXCL8
32 mitral valve disease 10.2 TGFB3 TGFB2 FBN1
33 chronic closed-angle glaucoma 10.2 TGFB2 AQP1
34 tuberculoid leprosy 10.2 TGFB3 TGFB2 TGFB1
35 aortic aneurysm, familial thoracic 1 10.2 TGFB3 TGFB2 FBN1
36 aneurysm 10.2 TGFB3 TGFB2 FBN1
37 iritis 10.2
38 corneal ulcer 10.2
39 neonatal marfan syndrome 10.2 FBN1 DCN
40 familial thoracic aortic aneurysm and aortic dissection 10.2 TGFB3 TGFB2 FBN1
41 toxicodendron dermatitis 10.2 SELE CXCL8
42 arachnoiditis 10.2 IL1A AQP4
43 synovial chondromatosis 10.2 TGFB3 BMP4
44 autoimmune optic neuritis 10.2 MIP AQP4
45 3-methylglutaconic aciduria, type iii 10.2
46 yemenite deaf-blind hypopigmentation syndrome 10.2
47 suppression amblyopia 10.2
48 amblyopia 10.2
49 corneal neovascularization 10.2
50 cytokine deficiency 10.2

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.38 AQP1 AQP3 AQP4 AQP9 BMP4 DCN
2 cardiovascular system MP:0005385 10.37 AQP1 AQP3 AQP4 BMP4 FBN1 IGF1
3 homeostasis/metabolism MP:0005376 10.33 AQP1 AQP3 AQP4 AQP9 BMP4 DCN
4 growth/size/body region MP:0005378 10.29 AQP1 AQP3 AQP4 BMP4 DCN FBN1
5 hematopoietic system MP:0005397 10.29 AQP1 AQP4 AQP9 BMP4 DCN FBN1
6 immune system MP:0005387 10.25 AQP1 AQP3 AQP4 AQP9 DCN FBN1
7 endocrine/exocrine gland MP:0005379 10.18 AQP1 AQP4 BMP4 DCN FBN1 IGF1
8 craniofacial MP:0005382 10.15 AQP3 BMP4 DCN FBN1 ITGB1 TGFB1
9 digestive/alimentary MP:0005381 10.14 AQP3 AQP4 BMP4 DCN ITGB1 TGFB1
10 hearing/vestibular/ear MP:0005377 10.1 AQP1 AQP3 AQP4 BMP4 IGF1 ITGB1
11 nervous system MP:0003631 10.1 AQP1 AQP4 AQP9 BMP4 FBN1 IGF1
12 muscle MP:0005369 9.97 BMP4 DCN FBN1 IGF1 ITGB1 NID1
13 renal/urinary system MP:0005367 9.96 AQP1 AQP3 AQP4 BMP4 DCN FBN1
14 limbs/digits/tail MP:0005371 9.95 AQP9 BMP4 FBN1 IGF1 ITGB1 TGFB2
15 respiratory system MP:0005388 9.93 AQP1 AQP3 AQP4 BMP4 DCN FBN1
16 skeleton MP:0005390 9.61 AQP9 BMP4 DCN FBN1 IGF1 ITGB1
17 vision/eye MP:0005391 9.4 AQP1 AQP3 AQP4 BMP4 DCN ITGB1

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 2
2
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved 83-88-5 493570
3 Vitamin B2
4 Antibiotics, Antitubercular
5 Mitomycins
6 Alkylating Agents
7 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
2 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
3 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
4 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
5 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
6 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
7 Comparative Long-term Results After DSAEK, UT-DSAEK and DMEK for Fuchs Endothelial Corneal Dystophy and Moderated Pseudophakic Bullous Keratopathy Completed NCT04424550
8 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
9 Descemet Membrane Endothelial Keratoplasty Combined With Intraocular Lens Exchange: Sequential Versus Combined Surgery Recruiting NCT04344522

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

40
Endothelial, Eye, Skin, Cortex, Retina

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 1447)
# Title Authors PMID Year
1
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. 54 61
20142847 2010
2
Interleukin-1alpha downregulates extracellular-superoxide dismutase in human corneal keratoconus stromal cells. 61 54
17679946 2007
3
Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. 54 61
14550395 2003
4
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. 54 61
11668187 2001
5
Decorin and biglycan of normal and pathologic human corneas. 54 61
9727420 1998
6
Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. 54 61
9620072 1998
7
Increased expression of fibrillin-1 in human corneas with bullous keratopathy. 61 54
9603388 1998
8
Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. 61 54
9603390 1998
9
Tenascin-cytotactin (TN-C) variants in pseudophakic/aphakic bullous keratopathy corneas. 61 54
9850274 1998
10
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. 61 54
7657553 1995
11
Immunosuppressive properties of cultured human cornea and ciliary body in normal and pathological conditions. 54 61
7582904 1995
12
Poor re-epithelialization following corneal collagen crosslinking with riboflavin-uva for advanced bullous keratopathy: Case series. 61
33618905 2021
13
Quantitative analysis of herpes simplex virus-1 transcript in suspected viral keratitis corneal buttons and its clinical significance. 61
33727446 2021
14
Systematic review of clinical research on regenerative medicine for the cornea. 61
33591470 2021
15
[Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 2017]. 61
31968370 2021
16
Long-term outcomes of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. 61
33723686 2021
17
Interface Fluid Syndrome 2 Decades After Laser-Assisted In situ Keratomileusis. 61
33560744 2021
18
Real-time intraoperative ultrasound biomicroscopy for determining graft orientation during Descemet's membrane endothelial keratoplasty. 61
32578923 2021
19
Recovery of Contrast Sensitivity After Descemet Membrane Endothelial Keratoplasty. 61
33591041 2021
20
Diseases of the corneal endothelium. 61
33596440 2021
21
Prevalence and risk factors to develop ocular hypertension and glaucoma after penetrating keratoplasty. 61
33642090 2021
22
Clinical Characteristics of Uveitis in Patients with Psoriasis in Korea: A Retrospective Multicenter Case Series. 61
33307622 2021
23
Long-Term Outcomes of Phototherapeutic Keratectomy for Bullous Keratopathy. 61
33605629 2021
24
Long-term Results of Intraocular Pressure Elevation and Post-DMEK Glaucoma After Descemet Membrane Endothelial Keratoplasty. 61
32558736 2021
25
Risk Factors for Repeat Descemet Membrane Endothelial Keratoplasty Graft Failure Short title: Factors Predicting Repeat DMEK Failure. 61
33493468 2021
26
Practice patterns of corneal transplantation in Europe: First report by the European Cornea and Cell Transplantation Registry (ECCTR). 61
33577274 2021
27
Extracellular matrix changes in corneal opacification vary depending on etiology. 61
33633437 2021
28
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema. 61
33470681 2021
29
[Explantation of the CyPass implant in a case series of patients with corneal decompensation]. 61
32350610 2021
30
Case Series: Novel Utilization of Rho-Kinase Inhibitor for the Treatment of Corneal Edema. 61
33269892 2021
31
Role of therapeutic contact lens following Descemet's stripping automated endothelial keratoplasty: A randomized control trial. 61
33323579 2021
32
Graft Failure and Repeat Penetrating Keratoplasty. 61
29697353 2021
33
Long-Term Maintenance of Corneal Endothelial Cell Density After Corneal Transplantation. 61
32482965 2020
34
Knot-free suture scleral fixation of dislocated intraocular lenses: the clinical results of a novel surgical technique. 61
33315738 2020
35
Therapeutic Contact Lenses in the Treatment of Corneal and Ocular Surface Diseases-A Review. 61
33181548 2020
36
Clinical Outcomes of Descemet Membrane Endothelial Keratoplasty in Pseudophakic Eyes Compared With Triple-DMEK at 1-Year Follow-up. 61
33369940 2020
37
Intraoperative performance and long-term postoperative outcomes after scleral fixation of IOLs with polytetrafluoroethylene suture. 61
32649434 2020
38
In-vivo and ex-vivo analysis of an unusual case of huge bullous keratopathy. 61
33120669 2020
39
Descemet stripping and automated endothelial keratoplasty (DSAEK) versus non-Descemet stripping and automated endothelial keratoplasty (nDSAEK) for bullous keratopathy. 61
32880043 2020
40
Comparative observation of the efficacy of simplified Descemet stripping endothelial keratoplasty and penetrating keratoplasty in treating bullous keratopathy. 61
32952622 2020
41
Randomized Control Trial on the Effectiveness of Collagen Cross-linking on Bullous Keratopathy. 61
33017120 2020
42
Free-Floating DMEK in the Host Anterior Chamber: Surgical Management. 61
32452994 2020
43
Two-year clinical outcome after Descemet membrane endothelial keratoplasty using a standardized protocol. 61
33120629 2020
44
Three-Year Outcomes of Tri-Folded Endothelium-In Descemet Membrane Endothelial Keratoplasty With Pull-Through Technique. 61
32659279 2020
45
Descemet Stripping Automated Endothelial Keratoplasty with Intrascleral Haptic Fixated Intraocular Lens in a Sequential versus Simultaneous approach. 61
33196567 2020
46
Descemet Membrane Endothelial Keratoplasty in Vascularized Eyes: Outcome and Effect on Corneal Neovascularization. 61
33252385 2020
47
Was it thickened Dua's layer? Clinical, tomographical, and histopathological correlation: A case report. 61
33256430 2020
48
Trocar-assisted, flanged haptics, sutureless intrascleral fixated intraocular lens implantation combined with Descemet membrane endothelial keratoplasty. 61
33470285 2020
49
Correlations between tear fluid and aqueous humor cytokine levels in bullous keratopathy. 61
32735951 2020
50
Conjunctival flap surgery in the management of ocular surface disease (Review). 61
32905115 2020

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.82 TNC TGFB3 TGFB2 TGFB1 ITGB1 IL1A
2
Show member pathways
13.54 TGFB3 TGFB2 TGFB1 ITGB1 IL1A IGF1
3
Show member pathways
13.41 TGFB3 TGFB2 TGFB1 ITGB1 IL1A IGF1
4
Show member pathways
13.4 TNC TGFB3 TGFB2 TGFB1 ITGB1 FBN1
5
Show member pathways
13.31 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
6
Show member pathways
13.21 TGFB3 TGFB2 TGFB1 IGF1 BMP4 AQP9
7
Show member pathways
13.04 TNC TGFB3 TGFB2 TGFB1 ITGB1 IGF1
8
Show member pathways
12.86 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
9
Show member pathways
12.86 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
10 12.84 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 CXCL8
11 12.77 TGFB3 TGFB2 TGFB1 IL1A IGF1
12
Show member pathways
12.73 TGFB3 TGFB2 TGFB1 IL1A IGF1 BMP4
13
Show member pathways
12.56 TNC TGFB3 TGFB2 TGFB1 NID1 ITGB1
14
Show member pathways
12.49 TNC TGFB1 NID1 ITGB1
15
Show member pathways
12.47 TGFB3 TGFB2 TGFB1 BMP4
16
Show member pathways
12.42 MIP ITGB1 AQP9 AQP4 AQP3 AQP1
17
Show member pathways
12.41 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 BMP4
18 12.34 TGFB2 TGFB1 ITGB1 IGF1 DCN
19
Show member pathways
12.29 TGFB3 TGFB2 TGFB1 ITGB1 IL1A
20
Show member pathways
12.28 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
21 12.25 TGFB3 TGFB2 TGFB1 BMP4
22 12.24 TGFB3 TGFB2 TGFB1 IL1A
23
Show member pathways
12.21 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
24 12.18 TGFB3 TGFB2 TGFB1 BMP4
25 12.17 TGFB3 TGFB2 TGFB1 IL1A CXCL8
26
Show member pathways
12.11 TGFB3 TGFB2 TGFB1 IGF1
27 12.09 TGFB1 ITGB1 IGF1 BMP4
28 12.01 TGFB1 ITGB1 IL1A CXCL8
29 12.01 TGFB1 IL1A CXCL8 AQP4 AQP1
30 11.97 TGFB1 IL1A IGF1 CXCL8
31 11.95 TGFB3 TGFB2 TGFB1 CXCL8
32 11.89 TGFB3 TGFB2 TGFB1
33 11.88 TGFB3 TGFB2 TGFB1 SELE IL1A CXCL8
34
Show member pathways
11.86 TGFB3 TGFB2 TGFB1
35 11.86 TGFB3 TGFB2 TGFB1 IL1A CXCL8
36 11.85 AQP9 AQP4 AQP1
37 11.82 TNC TGFB3 TGFB2 TGFB1 ITGB1
38 11.82 TGFB3 TGFB2 TGFB1 FBN1 DCN BMP4
39 11.77 ITGB1 IL1A CXCL8
40 11.74 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 BMP4
41 11.73 TGFB3 TGFB2 TGFB1 ITGB1
42 11.72 TGFB3 TGFB2 TGFB1 BMP4
43 11.7 TGFB2 TGFB1 IGF1
44
Show member pathways
11.68 SELE IL1A CXCL8
45 11.68 TGFB1 IGF1 CXCL8
46 11.68 NID1 ITGB1 IGF1 CXCL8
47
Show member pathways
11.66 TGFB3 TGFB2 TGFB1 ITGB1 FBN1 BMP4
48 11.62 TGFB2 SELE CXCL8
49 11.61 TGFB3 TGFB2 TGFB1
50 11.59 TGFB1 IGF1 BMP4

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 TNC TGFB3 TGFB2 TGFB1 SELE IL1A
2 extracellular region GO:0005576 9.73 TNC TGFB3 TGFB2 TGFB1 NID1 IL1A
3 extracellular matrix GO:0031012 9.72 TNC TGFB1 NID1 FBN1 DCN
4 basolateral plasma membrane GO:0016323 9.67 AQP9 AQP4 AQP3 AQP1
5 sarcolemma GO:0042383 9.61 ITGB1 AQP4 AQP1
6 basement membrane GO:0005604 9.58 TNC NID1 FBN1
7 platelet alpha granule lumen GO:0031093 9.56 TGFB3 TGFB2 TGFB1 IGF1
8 collagen-containing extracellular matrix GO:0062023 9.17 TNC TGFB3 TGFB2 TGFB1 NID1 FBN1

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 10.14 MIP AQP9 AQP4 AQP3 AQP1
2 positive regulation of cell proliferation GO:0008284 10.08 TNC TGFB3 TGFB2 TGFB1 IGF1 BMP4
3 cytokine-mediated signaling pathway GO:0019221 10.04 TGFB1 ITGB1 IL1A CXCL8
4 positive regulation of gene expression GO:0010628 10.03 TNC TGFB1 IL1A IGF1 CXCL8 BMP4
5 positive regulation of cell migration GO:0030335 10.02 TGFB1 ITGB1 IGF1 BMP4
6 heart development GO:0007507 10.02 TGFB2 TGFB1 FBN1 BMP4
7 negative regulation of gene expression GO:0010629 10.02 BMP4 CXCL8 IGF1 TGFB1 TGFB2
8 cellular protein metabolic process GO:0044267 10.01 TNC IGF1 FBN1 BMP4
9 negative regulation of cell proliferation GO:0008285 10.01 BMP4 CXCL8 IL1A TGFB1 TGFB2 TGFB3
10 regulation of cell proliferation GO:0042127 10 TNC TGFB3 TGFB2 TGFB1
11 positive regulation of angiogenesis GO:0045766 9.96 ITGB1 IL1A CXCL8 AQP1
12 skeletal system development GO:0001501 9.95 BMP4 FBN1 IGF1 TGFB2
13 extracellular matrix organization GO:0030198 9.95 TNC NID1 ITGB1 FBN1 DCN
14 kidney development GO:0001822 9.94 TGFB2 FBN1 DCN BMP4
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.91 TGFB2 IGF1 DCN
16 platelet degranulation GO:0002576 9.91 IGF1 TGFB1 TGFB2 TGFB3
17 neural tube closure GO:0001843 9.9 BMP4 TGFB1 TGFB2
18 response to wounding GO:0009611 9.89 TGFB1 TGFB2 TNC
19 negative regulation of epithelial cell proliferation GO:0050680 9.88 BMP4 TGFB1 TGFB2
20 positive regulation of epithelial cell proliferation GO:0050679 9.87 BMP4 IGF1 TGFB1
21 odontogenesis of dentin-containing tooth GO:0042475 9.87 BMP4 TGFB1 TNC
22 transforming growth factor beta receptor signaling pathway GO:0007179 9.87 ITGB1 TGFB1 TGFB2 TGFB3
23 inner ear development GO:0048839 9.86 TGFB1 TGFB2 TGFB3
24 positive regulation of fibroblast proliferation GO:0048146 9.84 TGFB1 IGF1 AQP1
25 response to progesterone GO:0032570 9.83 TGFB3 TGFB2 TGFB1
26 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.83 TGFB2 TGFB1 BMP4
27 BMP signaling pathway GO:0030509 9.83 TGFB3 TGFB2 TGFB1 BMP4
28 positive regulation of bone mineralization GO:0030501 9.82 TGFB3 TGFB1 BMP4
29 renal water homeostasis GO:0003091 9.81 AQP4 AQP3 AQP1
30 lung alveolus development GO:0048286 9.8 BMP4 TGFB1 TGFB3
31 SMAD protein signal transduction GO:0060395 9.8 TGFB3 TGFB2 TGFB1 BMP4
32 positive regulation of cell division GO:0051781 9.78 TGFB3 TGFB2 TGFB1 IL1A
33 cell-cell junction organization GO:0045216 9.76 TGFB3 TGFB2 TGFB1
34 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.76 TGFB3 TGFB2 TGFB1 BMP4
35 positive regulation of collagen biosynthetic process GO:0032967 9.75 TGFB3 TGFB1 BMP4
36 positive regulation of ossification GO:0045778 9.74 BMP4 TGFB2
37 pulmonary valve morphogenesis GO:0003184 9.74 BMP4 TGFB2
38 positive regulation of transcription regulatory region DNA binding GO:2000679 9.74 TGFB1 IGF1
39 positive regulation of fibroblast migration GO:0010763 9.74 TGFB1 ITGB1
40 cardiac right ventricle morphogenesis GO:0003215 9.74 TGFB2 BMP4
41 secondary palate development GO:0062009 9.74 TGFB2 TGFB3
42 pathway-restricted SMAD protein phosphorylation GO:0060389 9.73 TGFB2 TGFB1
43 mesodermal cell differentiation GO:0048333 9.73 ITGB1 BMP4
44 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.73 TGFB1 BMP4
45 cell activation GO:0001775 9.73 IGF1 TGFB1
46 multicellular organismal water homeostasis GO:0050891 9.73 AQP1 AQP4
47 positive regulation of epithelial to mesenchymal transition GO:0010718 9.73 TGFB3 TGFB2 TGFB1 BMP4
48 cellular response to insulin-like growth factor stimulus GO:1990314 9.72 TGFB1 FBN1
49 regulation of protein import into nucleus GO:0042306 9.71 TGFB1 BMP4
50 urea transmembrane transport GO:0071918 9.71 AQP9 AQP3

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.77 TGFB3 TGFB2 TGFB1 IGF1 BMP4
2 cytokine activity GO:0005125 9.73 TGFB3 TGFB2 TGFB1 IL1A CXCL8 BMP4
3 transforming growth factor beta receptor binding GO:0005160 9.58 TGFB3 TGFB2 TGFB1
4 type II transforming growth factor beta receptor binding GO:0005114 9.5 TGFB3 TGFB2 TGFB1
5 type I transforming growth factor beta receptor binding GO:0034713 9.49 TGFB3 TGFB1
6 urea transmembrane transporter activity GO:0015204 9.48 AQP9 AQP3
7 water transmembrane transporter activity GO:0005372 9.46 AQP9 AQP1
8 glycerol channel activity GO:0015254 9.43 AQP9 AQP3
9 channel activity GO:0015267 9.35 MIP AQP9 AQP4 AQP3 AQP1
10 type III transforming growth factor beta receptor binding GO:0034714 9.33 TGFB3 TGFB2 TGFB1
11 water channel activity GO:0015250 9.02 MIP AQP9 AQP4 AQP3 AQP1

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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