Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD10 33 H18.1
ICD9CM 35 371.23
NCIt 50 C26970
SNOMED-CT 68 57207003
UMLS 73 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to keratopathy and cataract, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and PAK Pathway. The drugs Pharmaceutical Solutions and Ophthalmic Solutions have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Bullous keratopathy is a pathological condition in which small vesicles, or bullae, are formed in the... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 keratopathy 31.5 TNC NID1 IL1A FBN1
2 cataract 10.3
3 corneal dystrophy, fuchs endothelial, 1 10.3
4 fuchs' endothelial dystrophy 10.3
5 stiff skin syndrome 10.2 TGFB2 FBN1
6 corneal disease 10.2
7 cryptogenic organizing pneumonia 10.1 TNC CXCL8
8 leukoregulin 10.1 IL1A CXCL8
9 scabies 10.1 IL1A CXCL8
10 interstitial keratitis 10.1 TNC DCN
11 neonatal marfan syndrome 10.1 FBN1 DCN
12 corneal dystrophy, posterior polymorphous, 3 10.1 TGFB2 BMP4
13 sebaceous gland disease 10.1 IL1A CXCL8
14 loeys-dietz syndrome 3 10.1 TGFB2 FBN1
15 radiculopathy 10.1 IL1A CXCL8
16 macular holes 10.1 TGFB2 CXCL8
17 peyronie's disease 10.1 TGFB2 DCN
18 synovial chondromatosis 10.1 BMP4 BMP2
19 oral candidiasis 10.1 IL1A CXCL8
20 fibrochondrogenesis 10.1 BMP4 BMP2
21 pulpitis 10.1 IL1A CXCL8
22 char syndrome 10.1 FBN1 BMP4
23 astigmatism 10.1
24 keratoconus 10.1
25 macular retinal edema 10.1
26 herpes simplex 10.1
27 tendinosis 10.0 TGFB2 DCN
28 localized scleroderma 10.0 SELE DCN
29 contact dermatitis 10.0 SELE IL1A CXCL8
30 proteasome-associated autoinflammatory syndrome 1 10.0 SELE IL1A CXCL8
31 bacterial sepsis 10.0 SELE CXCL8
32 osteomyelitis 9.9 IL1A CXCL8 BMP2
33 hydrarthrosis 9.9 MIP AQP3
34 osseous heteroplasia, progressive 9.9 DCN BMP4 BMP2
35 macular dystrophy, dominant cystoid 9.9
36 corneal endothelial dystrophy 9.9
37 werner syndrome 9.9
38 open-angle glaucoma 9.9
39 corneal edema 9.9
40 myopia 9.9
41 corneal ulcer 9.9
42 refractive error 9.9
43 endotheliitis 9.9
44 essential iris atrophy 9.9
45 osteochondroma 9.9 TGFB2 BMP2
46 osteoporosis 9.9 TGFB2 IL1A BMP4 BMP2
47 malaria 9.8 TGFB2 SELE IL1A CXCL8
48 skin disease 9.8 SELE IL1A CXCL8

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 AQP3 BMP2 BMP4 FBN1 IL1A NID1
2 homeostasis/metabolism MP:0005376 9.81 AQP3 BMP2 BMP4 DCN FBN1 IL1A
3 craniofacial MP:0005382 9.8 AQP3 BMP2 BMP4 DCN FBN1 TGFB2
4 hearing/vestibular/ear MP:0005377 9.65 AQP3 BMP2 BMP4 TGFB2 TNC
5 respiratory system MP:0005388 9.43 AQP3 BMP4 DCN FBN1 SELE TGFB2
6 vision/eye MP:0005391 9.17 AQP3 BMP4 DCN MIP NID1 SELE

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 3,Phase 2,Not Applicable
2 Ophthalmic Solutions Phase 3
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
5
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
6
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
7
Fluorometholone Approved, Investigational Phase 2,Not Applicable 426-13-1 9878
8
Bevacizumab Approved, Investigational Phase 2 216974-75-3
9
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
10 Anesthetics Phase 2
11 Antineoplastic Agents, Hormonal Phase 2,Not Applicable
12 Hormone Antagonists Phase 2,Not Applicable
13 Peripheral Nervous System Agents Phase 2,Not Applicable
14 Anti-Allergic Agents Phase 2
15 Gastrointestinal Agents Phase 2,Not Applicable
16 Prednisolone acetate Phase 2
17 Methylprednisolone acetate Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
19 Antiemetics Phase 2,Not Applicable
20 Autonomic Agents Phase 2,Not Applicable
21 Neuroprotective Agents Phase 2
22 glucocorticoids Phase 2,Not Applicable
23 Hormones Phase 2,Not Applicable
24 Protective Agents Phase 2
25 Anti-Inflammatory Agents Phase 2,Not Applicable
26 Mitogens Phase 2
27 Endothelial Growth Factors Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
31
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Not Applicable 83-88-5 493570
32 Micronutrients Not Applicable
33 Photosensitizing Agents Not Applicable
34 Vitamins Not Applicable
35 Vitamin B2 Not Applicable
36 Vitamin B9 Not Applicable
37 Dermatologic Agents Not Applicable
38 Folate Not Applicable
39 Trace Elements Not Applicable
40 Vitamin B Complex Not Applicable
41 Antibiotics, Antitubercular Not Applicable
42 Anti-Bacterial Agents Not Applicable
43 Nucleic Acid Synthesis Inhibitors Not Applicable
44 Mitomycins Not Applicable
45 Alkylating Agents Not Applicable

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Active, not recruiting NCT03248037 Phase 3 Netarsudil;Placebo
2 Amniotic Membrane Graft In Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
3 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
4 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
5 Corneal Transplantation Guided by OCT RESCAN Unknown status NCT02736877 Not Applicable
6 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
7 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
8 Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 Not Applicable saline solution
9 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
10 Long Term Results of Amniotic Membrane Transplant in Bullous Keratopathy Patients Completed NCT03450954
11 Amniotic Membrane and Anterior Stromal Puncture to the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308 Not Applicable
12 The Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking on the Signs and Symptoms of Bullous Keratopathy Completed NCT01106274 Not Applicable
13 Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy Completed NCT00654888 Not Applicable Mitomycin
14 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
15 Study of Endothelial Keratoplasty Outcomes Completed NCT00800111 Not Applicable
16 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
17 Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Recruiting NCT02660151 Not Applicable Salt solution
18 The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation Recruiting NCT03763721 Not Applicable
19 Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation Withdrawn NCT01682421 Not Applicable Weak steroid (Flurolon, Allergan);Potent steroid (Maxidex, Alcon)

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

41
Endothelial, Eye, Testes, Skin

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 280)
# Title Authors Year
1
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. ( 29534662 )
2018
2
Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy. ( 29539291 )
2018
3
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
4
Human corneal endothelial cell transplantation using nanocomposite gel sheet in bullous keratopathy. ( 29531856 )
2018
5
Painless bilateral bullous keratopathy. ( 29573998 )
2018
6
Topical ganciclovir treatment post-Descemet's stripping automated endothelial keratoplasty for patients with bullous keratopathy induced by cytomegalovirus. ( 29363530 )
2018
7
Dry eye and meibomian gland dysfunction in pseudophakic bullous keratopathy. ( 29392636 )
2018
8
Wheel Spokes Technique for Endothelial Keratoplasty for Extremely Mydriatic Bullous Keratopathy Eyes without Capsular Support. ( 29681843 )
2018
9
Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy. ( 29766356 )
2018
10
Bilateral bullous keratopathy secondary to melting keratitis in a Suri alpaca (<i>Vicugna pacos</i>). ( 29636928 )
2018
11
Glued intraocular lens with descemet stripping endothelial keratoplasty in aphakic bullous keratopathy. ( 29692490 )
2018
12
Sustainability of Pain Relief After Corneal Collagen Cross-Linking in Eyes With Bullous Keratopathy. ( 29993202 )
2018
13
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30231219 )
2018
14
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260152 )
2018
15
Cultured Cells and ROCK Inhibitor for Bullous Keratopathy. ( 30260153 )
2018
16
Cytokine levels in the aqueous humor are associated with corneal thickness in eyes with bullous keratopathy. ( 30316668 )
2018
17
Young donor-graft assisted endothelial keratoplasty (PDEK/DMEK) with epithelial debridement for chronic pseudophakic bullous keratopathy. ( 28985815 )
2017
18
Regulatory Compliant Tissue-Engineered Human Corneal Endothelial Grafts Restore Corneal Function of Rabbits with Bullous Keratopathy. ( 29074873 )
2017
19
Pseudophakic bullous keratopathy. ( 29450379 )
2017
20
Corneal Collagen Cross Linking (CXL) in treatment of Pseudophakic Bullous Keratopathy. ( 27648049 )
2016
21
Elevated Cytokine Levels in the Aqueous Humor of Eyes With Bullous Keratopathy and Low Endothelial Cell Density. ( 27820951 )
2016
22
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
23
Corneal Tattooing and Anterior Stromal Puncture for Treating Symptomatic Bullous Keratopathy. ( 26606297 )
2016
24
Non-Descemet Stripping Automated Endothelial Keratoplasty for Bullous Keratopathy in Buphthalmic Eye. ( 27462256 )
2016
25
Superficial Keratectomy and Conjunctival Advancement Hood Flap (SKCAHF) for the Management of Bullous Keratopathy: Validation in Dogs With Spontaneous Disease. ( 27538190 )
2016
26
An association between systemic cyclosporine administration and development of acute bullous keratopathy in cats. ( 26880480 )
2016
27
Comparison of Long-term Clinical Outcomes between Descemet's Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty in Patients with Bullous Keratopathy. ( 27980363 )
2016
28
Changes in Corneal Biomechanical Properties After Descemet Stripping Automated Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. ( 26555584 )
2015
29
Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for bullous keratopathy. ( 26541104 )
2015
30
Evaluation of accelerated corneal collagen cross-linking for the treatment of bullous keratopathy in eight dogs (10 eyes). ( 25959108 )
2015
31
Case series and techniques of Descemet's Stripping Automated Endothelial Keratoplasty for severe bullous keratopathy after birth injury. ( 26245501 )
2015
32
Effect of Glyceraldehyde Cross-Linking on a Rabbit Bullous Keratopathy Model. ( 26509077 )
2015
33
Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy. ( 26491241 )
2015
34
Simultaneous Descemet's membrane endothelial keratoplasty and posterior iris-claw-fixated intra ocular lens implantation (IOL) in management of aphakic bullous keratopathy. ( 26286755 )
2015
35
Real-Time Microscope-Integrated OCT to Improve Visualization in DSAEK for Advanced Bullous Keratopathy. ( 26509766 )
2015
36
The use of endoillumination probe-assisted Descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy. ( 25609910 )
2015
37
Long-term symptomatic relief of bullous keratopathy with amniotic membrane transplant. ( 25586624 )
2015
38
Occult Descemet's membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy. ( 29018686 )
2015
39
Alternatives to corneal transplantation for the management of bullous keratopathy. ( 24807064 )
2014
40
Three-year outcome of Descemet stripping automated endothelial keratoplasty for bullous keratopathy after argon laser iridotomy. ( 24915015 )
2014
41
Outcomes of corneal collagen crosslinking in pseudophakic bullous keratopathy. ( 24452209 )
2014
42
Re: Arora etA al.: Role of Corneal Collagen Cross-Linking in Pseudophakic Bullous Keratopathy: AA Clinicopathological Study (Ophthalmology 2013;120:2413-8). ( 25015213 )
2014
43
Use of amniotic membrane in bullous keratopathy palliative care. ( 25870682 )
2014
44
Ultrasound biomicroscopy after palliative surgical procedures for bullous keratopathy: a descriptive comparative study. ( 25627186 )
2014
45
Endoilluminator-assisted transcorneal illumination for Descemet membrane endothelial keratoplasty: enhanced intraoperative visualization of the graft in corneal decompensation secondary to pseudophakic bullous keratopathy. ( 25088633 )
2014
46
Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs' Endothelial Dystrophy. ( 25484904 )
2014
47
Femtosecond laser-assisted intracorneal biopolymer insertion for the symptomatic treatment of bullous keratopathy. ( 24619170 )
2014
48
Comparison of sulfur hexafluoride and air for donor attachment in Descemet stripping endothelial keratoplasty in patients with pseudophakic bullous keratopathy. ( 24452211 )
2014
49
Superficial epithelial keratectomy, cautery, and amniotic membrane transplant for the treatment of painful bullous keratopathy in eyes with poor visual potential. ( 24815111 )
2014
50
Regeneration of corneal endothelial cells following keratoplasty in rats with bullous keratopathy. ( 24883013 )
2014

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2
2
Show member pathways
13.1 BMP2 BMP4 CXCL8 IL1A TGFB2
3
Show member pathways
12.84 BMP2 BMP4 FBN1 TGFB2 TNC
4 12.64 BMP2 BMP4 CXCL8 TGFB2
5
Show member pathways
12.49 BMP2 BMP4 IL1A TGFB2
6
Show member pathways
12.03 CXCL8 FBN1 IL1A TNC
7 11.98 CXCL8 IL1A TGFB2
8
Show member pathways
11.98 BMP2 BMP4 CXCL8 IL1A TGFB2
9 11.95 BMP2 BMP4 TGFB2
10 11.89 BMP4 IL1A SELE
11 11.87 BMP2 BMP4 TGFB2
12
Show member pathways
11.82 BMP2 BMP4 DCN FBN1 NID1 TGFB2
13
Show member pathways
11.81 BMP2 BMP4 CXCL8 IL1A TGFB2
14 11.74 BMP2 CXCL8 IL1A
15 11.65 CXCL8 IL1A TGFB2
16 11.62 CXCL8 IL1A SELE TGFB2
17 11.51 BMP2 BMP4 TGFB2
18
Show member pathways
11.49 CXCL8 IL1A SELE
19 11.48 BMP2 BMP4 DCN TGFB2
20 11.43 DCN TGFB2 TNC
21 11.39 CXCL8 SELE TGFB2
22 11.32 CXCL8 SELE TGFB2
23
Show member pathways
11.32 BMP2 BMP4 FBN1 TGFB2
24 11.17 CXCL8 DCN
25 11.02 BMP2 BMP4
26 10.96 BMP2 BMP4 CXCL8 IL1A
27 10.93 BMP2 BMP4
28 10.67 BMP2 DCN
29 10.4 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BMP2 BMP4 CXCL8 DCN FBN1 IL1A
2 extracellular matrix GO:0031012 9.56 DCN FBN1 NID1 TNC
3 collagen-containing extracellular matrix GO:0062023 9.55 DCN FBN1 NID1 TGFB2 TNC
4 basement membrane GO:0005604 9.5 FBN1 NID1 TNC
5 extracellular space GO:0005615 9.28 BMP2 BMP4 CXCL8 DCN FBN1 IL1A

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.96 BMP2 BMP4 IL1A TNC
2 inflammatory response GO:0006954 9.94 BMP2 CXCL8 IL1A SELE
3 heart development GO:0007507 9.88 BMP2 BMP4 FBN1 TGFB2
4 cellular protein metabolic process GO:0044267 9.86 BMP4 FBN1 TNC
5 negative regulation of cell proliferation GO:0008285 9.85 BMP2 BMP4 CXCL8 IL1A TGFB2
6 extracellular matrix organization GO:0030198 9.81 DCN FBN1 NID1 TNC
7 osteoblast differentiation GO:0001649 9.79 BMP2 BMP4 TNC
8 wound healing GO:0042060 9.78 DCN TGFB2 TNC
9 cell development GO:0048468 9.73 BMP2 BMP4 TGFB2
10 regulation of MAPK cascade GO:0043408 9.72 BMP2 BMP4 TGFB2
11 SMAD protein signal transduction GO:0060395 9.71 BMP2 BMP4 TGFB2
12 skeletal system development GO:0001501 9.71 BMP2 BMP4 FBN1 TGFB2
13 odontogenesis of dentin-containing tooth GO:0042475 9.7 BMP2 BMP4 TNC
14 epithelial to mesenchymal transition GO:0001837 9.69 BMP2 TGFB2
15 cellular response to BMP stimulus GO:0071773 9.68 BMP2 BMP4
16 metanephros development GO:0001656 9.68 BMP4 FBN1
17 positive regulation of bone mineralization GO:0030501 9.68 BMP2 BMP4
18 telencephalon development GO:0021537 9.67 BMP2 BMP4
19 outflow tract septum morphogenesis GO:0003148 9.67 BMP4 TGFB2
20 cardiac muscle cell differentiation GO:0055007 9.67 BMP2 BMP4
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.67 BMP2 BMP4 TGFB2
22 water transport GO:0006833 9.66 AQP3 MIP
23 embryonic digestive tract development GO:0048566 9.65 CXCL8 TGFB2
24 endocardial cushion morphogenesis GO:0003203 9.65 BMP2 TGFB2
25 positive regulation of cartilage development GO:0061036 9.65 BMP2 BMP4
26 positive regulation of epithelial to mesenchymal transition GO:0010718 9.65 BMP2 BMP4 TGFB2
27 cardiac right ventricle morphogenesis GO:0003215 9.64 BMP4 TGFB2
28 pulmonary valve morphogenesis GO:0003184 9.63 BMP4 TGFB2
29 cardiac epithelial to mesenchymal transition GO:0060317 9.63 BMP2 TGFB2
30 pathway-restricted SMAD protein phosphorylation GO:0060389 9.62 BMP2 TGFB2
31 atrioventricular valve morphogenesis GO:0003181 9.62 BMP2 TGFB2
32 membranous septum morphogenesis GO:0003149 9.6 BMP4 TGFB2
33 pharyngeal arch artery morphogenesis GO:0061626 9.59 BMP4 TGFB2
34 telencephalon regionalization GO:0021978 9.58 BMP2 BMP4
35 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.57 BMP2 BMP4
36 odontogenesis GO:0042476 9.54 AQP3 BMP4 TGFB2
37 kidney development GO:0001822 9.46 BMP4 DCN FBN1 TGFB2
38 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.43 BMP2 BMP4
39 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.43 BMP2 BMP4 TGFB2
40 BMP signaling pathway involved in heart induction GO:0003130 9.32 BMP2 BMP4
41 positive regulation of ossification GO:0045778 9.13 BMP2 BMP4 TGFB2
42 regulation of signaling receptor activity GO:0010469 9.1 BMP2 BMP4 CXCL8 FBN1 IL1A TGFB2

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.58 BMP2 BMP4 TGFB2
2 extracellular matrix structural constituent GO:0005201 9.54 FBN1 NID1 TNC
3 extracellular matrix binding GO:0050840 9.46 DCN NID1
4 channel activity GO:0015267 9.43 AQP3 MIP
5 water channel activity GO:0015250 9.32 AQP3 MIP
6 co-receptor binding GO:0039706 9.26 BMP2 BMP4
7 BMP receptor binding GO:0070700 9.16 BMP2 BMP4
8 transforming growth factor beta receptor binding GO:0005160 9.13 BMP2 BMP4 TGFB2
9 cytokine activity GO:0005125 9.02 BMP2 BMP4 CXCL8 IL1A TGFB2

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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