MCID: BLL004
MIFTS: 49

Bullous Keratopathy

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD9CM 34 371.23
NCIt 49 C26970
SNOMED-CT 67 57207003
ICD10 32 H18.1
UMLS 71 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to corneal disease and keratoconus, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Bevacizumab and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and t cells, and related phenotypes are cardiovascular system and behavior/neurological

Wikipedia : 74 Bullous keratopathy, also known as pseudophakic bullous keratopathy (PBK), is a pathological condition... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 156)
# Related Disease Score Top Affiliating Genes
1 corneal disease 30.6 TGFB2 IL1A DCN CXCL8
2 keratoconus 30.5 TGFB2 TGFB1 IL1A FBN1
3 intraocular pressure quantitative trait locus 30.1 TGFB2 MIP FBN1 BMP4 AQP4 AQP1
4 keratopathy 29.8 TGFB3 TGFB2 NID1 ITGB1 IL1A IGF1
5 retinal detachment 29.8 TGFB2 TGFB1 IGF1 CXCL8
6 cataract 28.7 TGFB3 TGFB2 TGFB1 MIP IGF1 FBN1
7 myopia 28.7 TGFB2 TGFB1 IGF1 FBN1 DCN BMP2
8 corneal edema 10.8
9 corneal dystrophy, fuchs endothelial, 1 10.6
10 macular retinal edema 10.5
11 astigmatism 10.5
12 keratitis, hereditary 10.5
13 fuchs' endothelial dystrophy 10.5
14 macular degeneration, age-related, 1 10.3
15 fuchs' heterochromic uveitis 10.3 TGFB2 CXCL8
16 corneal dystrophy 10.3
17 refractive error 10.3
18 toxicodendron dermatitis 10.3 SELE CXCL8
19 tricuspid valve prolapse 10.3 TGFB3 TGFB2 FBN1
20 loeys-dietz syndrome 5 10.3 TGFB3 TGFB2 FBN1
21 loeys-dietz syndrome 10.3 TGFB3 TGFB2 FBN1
22 heritable thoracic aortic disease 10.3 TGFB3 TGFB2 FBN1
23 loeys-dietz syndrome 3 10.3 TGFB3 TGFB2 FBN1
24 loeys-dietz syndrome 4 10.3 TGFB3 TGFB2 FBN1
25 acute transverse myelitis 10.3 CXCL8 AQP4
26 neonatal marfan syndrome 10.3 FBN1 DCN
27 aortic dissection 10.3 TGFB3 TGFB2 FBN1
28 iritis 10.3
29 corneal ulcer 10.3
30 loeys-dietz syndrome 1 10.3 TGFB3 TGFB2 FBN1
31 autoimmune optic neuritis 10.2 MIP AQP4
32 mitral valve disease 10.2 TGFB3 TGFB2 FBN1
33 subependymoma 10.2 AQP4 AQP1
34 familial thoracic aortic aneurysm and aortic dissection 10.2 TGFB3 TGFB2 FBN1
35 aneurysm 10.2 TGFB3 TGFB2 FBN1
36 aortic aneurysm, familial thoracic 1 10.2 TGFB3 TGFB2 FBN1
37 yemenite deaf-blind hypopigmentation syndrome 10.2
38 joint laxity, short stature, and myopia 10.2
39 suppression amblyopia 10.2
40 amblyopia 10.2
41 corneal neovascularization 10.2
42 herpes simplex 10.2
43 endotheliitis 10.2
44 dysferlinopathy 10.2 MIP AQP4 AQP1
45 stiff skin syndrome 10.2 TGFB2 TGFB1 FBN1
46 aphthous stomatitis 10.2 SELE IL1A CXCL8
47 inappropriate adh syndrome 10.2 AQP4 AQP3 AQP1
48 contact dermatitis 10.1 SELE IL1A CXCL8
49 proteasome-associated autoinflammatory syndrome 1 10.1 SELE IL1A CXCL8
50 leukoregulin 10.1 TGFB1 IL1A CXCL8

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

45 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 AQP1 AQP3 AQP4 BMP2 BMP4 FBN1
2 behavior/neurological MP:0005386 10.41 AQP1 AQP3 AQP4 AQP9 BMP4 DCN
3 homeostasis/metabolism MP:0005376 10.41 AQP1 AQP3 AQP4 AQP9 BMP2 BMP4
4 hematopoietic system MP:0005397 10.37 AQP1 AQP4 AQP9 BMP2 BMP4 DCN
5 growth/size/body region MP:0005378 10.36 AQP1 AQP3 AQP4 BMP2 BMP4 DCN
6 cellular MP:0005384 10.32 BMP2 BMP4 DCN FBN1 IGF1 ITGB1
7 immune system MP:0005387 10.31 AQP3 AQP4 AQP9 BMP2 DCN FBN1
8 mortality/aging MP:0010768 10.27 AQP1 AQP3 AQP4 BMP2 BMP4 DCN
9 craniofacial MP:0005382 10.23 AQP3 BMP2 BMP4 DCN FBN1 ITGB1
10 digestive/alimentary MP:0005381 10.22 AQP3 AQP4 BMP2 BMP4 DCN ITGB1
11 endocrine/exocrine gland MP:0005379 10.21 AQP1 AQP4 BMP4 DCN FBN1 IGF1
12 hearing/vestibular/ear MP:0005377 10.19 AQP1 AQP3 AQP4 BMP2 BMP4 IGF1
13 nervous system MP:0003631 10.18 AQP1 AQP4 BMP2 BMP4 FBN1 IGF1
14 limbs/digits/tail MP:0005371 10.08 AQP9 BMP2 BMP4 FBN1 IGF1 ITGB1
15 muscle MP:0005369 10.03 BMP4 DCN FBN1 IGF1 ITGB1 NID1
16 renal/urinary system MP:0005367 10.02 AQP1 AQP3 AQP4 BMP4 DCN FBN1
17 normal MP:0002873 9.97 BMP2 BMP4 DCN IGF1 ITGB1 SELE
18 respiratory system MP:0005388 9.93 AQP1 AQP3 AQP4 BMP4 DCN FBN1
19 reproductive system MP:0005389 9.91 AQP1 BMP2 BMP4 DCN FBN1 IGF1
20 skeleton MP:0005390 9.73 AQP1 AQP3 AQP9 BMP2 BMP4 DCN
21 vision/eye MP:0005391 9.4 AQP1 AQP3 AQP4 BMP4 DCN ITGB1

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2 Anesthetics Phase 2
3 Mitogens Phase 2
4 Endothelial Growth Factors Phase 2
5 Angiogenesis Inhibitors Phase 2
6 Antineoplastic Agents, Immunological Phase 2
7
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 1 83-88-5 493570
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
9 Vitamin B2 Phase 1
10 Pharmaceutical Solutions Phase 1
11 Trace Elements Phase 1
12 Micronutrients Phase 1
13 Vitamins Phase 1
14 Vitamin B Complex Phase 1
15 Nutrients Phase 1
16 Folate Phase 1
17 Dermatologic Agents Phase 1
18 Photosensitizing Agents Phase 1
19 Ophthalmic Solutions Phase 1
20 Vitamin B9 Phase 1
21 Alkylating Agents
22 Mitomycins
23 Anti-Bacterial Agents
24 Antibiotics, Antitubercular

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
2 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
3 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
4 Phase 1 Clinical Study to Evaluate Safety and Tolerability of Magnetic Human Corneal Endothelial Cells in the Treatment of Corneal Edema Recruiting NCT04191629 Phase 1
5 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
6 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
7 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
8 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
9 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
10 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
11 Comparative Long-term Results After DSAEK, UT-DSAEK and DMEK for Fuchs Endothelial Corneal Dystophy and Moderated Pseudophakic Bullous Keratopathy Completed NCT04424550
12 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
13 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
14 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
15 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374
16 The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK Recruiting NCT04387331
17 Keratoconus, Corneal Diseases and Transplant Registry (KCDTR) Recruiting NCT04164407
18 Evaluating Corneal Edema in Fuchs' Endothelial Dystrophy Using Optical Coherence Tomography Not yet recruiting NCT04258787
19 Descemet Membrane Endothelial Keratoplasty Combined With Intraocular Lens Exchange: Sequential Versus Combined Surgery Not yet recruiting NCT04344522

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

40
Endothelial, Eye, T Cells, Cortex, Colon, Skin, Testes

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 1398)
# Title Authors PMID Year
1
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. 54 61
20142847 2010
2
Interleukin-1alpha downregulates extracellular-superoxide dismutase in human corneal keratoconus stromal cells. 61 54
17679946 2007
3
Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. 61 54
14550395 2003
4
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. 61 54
11668187 2001
5
Decorin and biglycan of normal and pathologic human corneas. 61 54
9727420 1998
6
Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. 61 54
9620072 1998
7
Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. 54 61
9603390 1998
8
Increased expression of fibrillin-1 in human corneas with bullous keratopathy. 54 61
9603388 1998
9
Tenascin-cytotactin (TN-C) variants in pseudophakic/aphakic bullous keratopathy corneas. 54 61
9850274 1998
10
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. 61 54
7657553 1995
11
Immunosuppressive properties of cultured human cornea and ciliary body in normal and pathological conditions. 61 54
7582904 1995
12
Long-term Results of Intraocular Pressure Elevation and Post-DMEK Glaucoma After Descemet Membrane Endothelial Keratoplasty. 61
32558736 2020
13
Resolution of Corneal Fibrosis After Descemet's Stripping Automated Endothelial Keratoplasty: A Case Report. 61
32144575 2020
14
Descemet's membrane development, structure, function and regeneration. 61
32522478 2020
15
Corneal Blindness in Asia: A Systematic Review and Meta-Analysis to Identify Challenges and Opportunities. 61
32501834 2020
16
Overall clinical outcomes of Descemet membrane endothelial keratoplasty in 600 consecutive eyes: A large retrospective case series. 61
32461427 2020
17
Real-time intraoperative ultrasound biomicroscopy for determining graft orientation during Descemet's membrane endothelial keratoplasty. 61
32578923 2020
18
A Novel Approach of Harvesting Viable Single Cells from Donor Corneal Endothelium for Cell-Injection Therapy. 61
32526886 2020
19
Bowman's layer in the cornea- structure and function and regeneration. 61
32339517 2020
20
Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. 61
31462418 2020
21
Cases With Long-Term High Corneal Endothelial Cell Density Maintained After Corneal Transplantation. 61
32482965 2020
22
Descemet Membrane Endothelial Keratoplasty in Asian Eyes: Intraoperative and Postoperative Complications. 61
32452991 2020
23
Free-Floating DMEK in the Host Anterior Chamber: Surgical Management. 61
32452994 2020
24
Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty. 61
31789922 2020
25
Descemet Membrane Endothelial Keratoplasty With a Pull-Through Insertion Device: Surgical Technique, Endothelial Cell Loss, and Early Clinical Results. 61
31996538 2020
26
Clinical Evaluation of the "Lifeline Suture" Technique for DSAEK in Cases Without Posterior Capsule Using a Novel Donor Insertion Device. 61
31809287 2020
27
A 27-Year Report from the Central Eye Bank of Iran. 61
32308948 2020
28
[Explantation of the CyPass implant in a case series of patients with corneal decompensation]. 61
32350610 2020
29
Femtosecond laser-assisted Descemet's stripping endothelial keratoplasty: a prospective study of 6-month visual outcomes, corneal thickness and endothelial cell loss. 61
32318937 2020
30
Retropupillary iris-claw intraocular lens implantation in aphakic patients. 61
32174577 2020
31
Effect of Surgical Indication and Preoperative Lens Status on Descemet Membrane Endothelial Keratoplasty Outcomes. 61
31863726 2020
32
Transcription Factor 4 Regulates the Regeneration of Corneal Endothelial Cells. 61
32301972 2020
33
Endothelial corneal transplants: indications, clinical profile and surgical outcomes in a tertiary care hospital. 61
32476714 2020
34
Bacterial keratitis due to Moraxella nonliquefaciens. 61
32241585 2020
35
Changing Trends in Penetrating Keratoplasty Indications between 2011 and 2018 - Histopathology of 2123 Corneal Buttons in a Single Center in Germany. 61
32114836 2020
36
Conjunctival Flaps: A Case Series and Review of the Literature. 61
30829689 2020
37
Conjunctival Epithelial Ingrowth After Penetrating Keratoplasty. 61
32341316 2020
38
Suprachoroidal Hemorrhage During Descemet Membrane Endothelial Keratoplasty. 61
31714406 2020
39
Five-Year Graft Survival and Clinical Outcomes of 500 Consecutive Cases After Descemet Membrane Endothelial Keratoplasty. 61
31478948 2020
40
Risk Factors for the Development of Ocular Hypertension After Keratoplasty: A Systematic Review. 61
31764288 2020
41
Decreased epithelial to corneal thickness ratio in healthy fellow eyes of patients with unilateral bullous keratopathy. 61
31000511 2020
42
Unusual aetiology of keratitis in a patient with bullous keratopathy. 61
31383374 2020
43
Intraocular lens explantation in Spain: indications and outcomes at a tertiary referral center from 2010 to 2018. 61
31565759 2020
44
Contact Lenses in the Management of Corneal Dystrophies. 61
30736080 2020
45
Optimisation of Storage and Transportation Conditions of Cultured Corneal Endothelial Cells for Cell Replacement Therapy. 61
32015414 2020
46
Successful surgical management of post-penetrating or deep lamellar keratoplasty Acquired Corneal Sub-Epithelial Hypertrophy (ACSH): A case series. 61
32062505 2020
47
Graft Detachment After Descemet's Stripping Automated Endothelial Keratoplasty in Bullous Keratopathy and Fuchs Dystrophy. 61
31976339 2020
48
Hybrid Descemet Membrane Endothelial Keratoplasty (H-DMEK): results of a donor insertion pull-through technique using donor stroma as carrier. 61
31949091 2020
49
SURVEY OF CLINICAL OPHTHALMIC DISEASE IN THE GIANT PANDA (AILUROPODA MELANOLEUCA) AMONG NORTH AMERICAN ZOOLOGICAL INSTITUTIONS. 61
31926513 2020
50
Descemet membrane endothelial keratoplasty and intraocular lens implantation in cases of aphakic bullous keratopathy. 61
32105503 2020

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 TNC TGFB3 TGFB2 TGFB1 ITGB1 IL1A
2
Show member pathways
13.57 TGFB3 TGFB2 TGFB1 ITGB1 IL1A IGF1
3
Show member pathways
13.44 TGFB3 TGFB2 TGFB1 ITGB1 IL1A IGF1
4
Show member pathways
13.42 TNC TGFB3 TGFB2 TGFB1 ITGB1 FBN1
5
Show member pathways
13.33 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
6
Show member pathways
13.23 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
7
Show member pathways
13.07 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
8
Show member pathways
13.04 TNC TGFB3 TGFB2 TGFB1 ITGB1 IGF1
9
Show member pathways
12.87 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
10
Show member pathways
12.87 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
11 12.85 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 CXCL8
12 12.78 TGFB3 TGFB2 TGFB1 IL1A IGF1
13
Show member pathways
12.72 TGFB3 TGFB2 TGFB1 IL1A IGF1 BMP4
14
Show member pathways
12.61 TNC TGFB3 TGFB2 TGFB1 NID1 ITGB1
15
Show member pathways
12.51 TGFB3 TGFB2 TGFB1 BMP4 BMP2
16
Show member pathways
12.5 TNC TGFB1 NID1 ITGB1
17
Show member pathways
12.48 MIP ITGB1 AQP9 AQP4 AQP3 AQP1
18
Show member pathways
12.43 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 BMP4
19 12.36 TGFB2 TGFB1 ITGB1 IGF1 DCN
20
Show member pathways
12.33 TGFB1 IGF1 BMP4 BMP2
21
Show member pathways
12.32 TGFB3 TGFB2 TGFB1 ITGB1 IL1A
22
Show member pathways
12.31 TGFB3 TGFB2 TGFB1 ITGB1 IGF1
23 12.26 TGFB3 TGFB2 TGFB1 BMP4
24 12.25 TGFB3 TGFB2 TGFB1 IL1A
25
Show member pathways
12.22 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
26 12.21 TGFB3 TGFB2 TGFB1 BMP4 BMP2
27 12.2 TGFB3 TGFB2 TGFB1 IL1A CXCL8
28
Show member pathways
12.13 TGFB3 TGFB2 TGFB1 IGF1
29 12.11 TGFB1 ITGB1 IGF1 BMP4
30 12.1 TGFB1 IGF1 BMP4 BMP2
31 12.05 TGFB1 IL1A CXCL8 AQP4 AQP1
32 12.02 TGFB1 ITGB1 IL1A CXCL8
33 11.99 TGFB1 IL1A IGF1 CXCL8 BMP2
34 11.97 TGFB3 TGFB2 TGFB1 CXCL8
35 11.91 TGFB3 TGFB2 TGFB1 IL1A CXCL8
36 11.91 TGFB3 TGFB2 TGFB1 SELE IL1A CXCL8
37 11.89 TGFB3 TGFB2 TGFB1
38 11.88 TNC TGFB3 TGFB2 TGFB1 ITGB1
39
Show member pathways
11.86 TGFB3 TGFB2 TGFB1
40 11.85 AQP9 AQP4 AQP1
41 11.84 TGFB3 TGFB2 TGFB1 FBN1 DCN BMP4
42 11.8 IGF1 BMP4 BMP2
43 11.78 ITGB1 IL1A CXCL8
44 11.76 TGFB3 TGFB2 TGFB1 BMP4 BMP2
45 11.74 TGFB3 TGFB2 TGFB1 ITGB1 IGF1 BMP4
46 11.71 NID1 ITGB1 IGF1 CXCL8
47 11.7 TGFB2 TGFB1 IGF1
48
Show member pathways
11.69 SELE IL1A CXCL8
49 11.68 TGFB1 IGF1 CXCL8
50 11.62 TGFB2 SELE CXCL8

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNC TGFB3 TGFB2 TGFB1 NID1 IL1A
2 extracellular matrix GO:0031012 9.72 TNC TGFB1 NID1 FBN1 DCN
3 collagen-containing extracellular matrix GO:0062023 9.7 TNC TGFB3 TGFB2 TGFB1 NID1 FBN1
4 basolateral plasma membrane GO:0016323 9.67 AQP9 AQP4 AQP3 AQP1
5 basement membrane GO:0005604 9.58 TNC NID1 FBN1
6 platelet alpha granule lumen GO:0031093 9.56 TGFB3 TGFB2 TGFB1 IGF1
7 extracellular space GO:0005615 9.4 TNC TGFB3 TGFB2 TGFB1 SELE IL1A

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TGFB3 TGFB1 IL1A IGF1 DCN BMP4
2 inflammatory response GO:0006954 10.11 TGFB1 SELE IL1A CXCL8 BMP2
3 positive regulation of apoptotic process GO:0043065 10.11 TGFB3 TGFB1 ITGB1 BMP4 BMP2
4 positive regulation of gene expression GO:0010628 10.11 TNC TGFB1 IL1A IGF1 BMP4 BMP2
5 positive regulation of cell proliferation GO:0008284 10.1 TNC TGFB3 TGFB2 TGFB1 ITGB1 IGF1
6 cytokine-mediated signaling pathway GO:0019221 10.07 TGFB1 ITGB1 IL1A CXCL8
7 negative regulation of gene expression GO:0010629 10.06 TGFB2 TGFB1 IGF1 BMP4 BMP2
8 cellular protein metabolic process GO:0044267 10.04 TNC IGF1 FBN1 BMP4
9 regulation of cell proliferation GO:0042127 10.04 TNC TGFB3 TGFB2 TGFB1
10 negative regulation of cell proliferation GO:0008285 10.04 TGFB3 TGFB2 TGFB1 IL1A CXCL8 BMP4
11 extracellular matrix organization GO:0030198 10.03 TNC NID1 ITGB1 FBN1 DCN
12 positive regulation of cell migration GO:0030335 10.02 TGFB1 ITGB1 IGF1 BMP4 BMP2
13 response to hypoxia GO:0001666 10.01 TGFB3 TGFB2 TGFB1 BMP2
14 heart development GO:0007507 10.01 TGFB2 TGFB1 FBN1 BMP4 BMP2
15 positive regulation of angiogenesis GO:0045766 9.99 ITGB1 IL1A CXCL8 AQP1
16 skeletal system development GO:0001501 9.97 TGFB2 IGF1 FBN1 BMP4 BMP2
17 platelet degranulation GO:0002576 9.96 TGFB3 TGFB2 TGFB1 IGF1
18 kidney development GO:0001822 9.96 TGFB2 FBN1 DCN BMP4
19 transforming growth factor beta receptor signaling pathway GO:0007179 9.96 TGFB3 TGFB2 TGFB1 ITGB1
20 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.93 TGFB2 IGF1 DCN
21 neural tube closure GO:0001843 9.93 TGFB2 TGFB1 BMP4
22 response to wounding GO:0009611 9.93 TNC TGFB2 TGFB1
23 cellular response to growth factor stimulus GO:0071363 9.92 TGFB1 BMP4 BMP2
24 negative regulation of epithelial cell proliferation GO:0050680 9.91 TGFB2 TGFB1 BMP4
25 positive regulation of epithelial cell proliferation GO:0050679 9.91 TGFB1 IGF1 BMP4
26 positive regulation of osteoblast differentiation GO:0045669 9.91 IGF1 BMP4 BMP2
27 odontogenesis of dentin-containing tooth GO:0042475 9.9 TNC BMP4 BMP2
28 positive regulation of fibroblast proliferation GO:0048146 9.89 TGFB1 IGF1 AQP1
29 inner ear development GO:0048839 9.88 TGFB3 TGFB2 TGFB1 BMP2
30 negative regulation of cell cycle GO:0045786 9.87 TGFB1 BMP4 BMP2
31 chondrocyte differentiation GO:0002062 9.87 TGFB1 BMP4 BMP2
32 epithelial to mesenchymal transition GO:0001837 9.87 TGFB2 TGFB1 BMP2
33 response to progesterone GO:0032570 9.86 TGFB3 TGFB2 TGFB1
34 renal water homeostasis GO:0003091 9.85 AQP4 AQP3 AQP1
35 wound healing GO:0042060 9.85 TNC TGFB3 TGFB2 TGFB1 DCN
36 positive regulation of cell division GO:0051781 9.84 TGFB3 TGFB2 TGFB1 IL1A
37 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.81 TGFB2 TGFB1 BMP4 BMP2
38 positive regulation of collagen biosynthetic process GO:0032967 9.8 TGFB3 TGFB1 BMP4
39 BMP signaling pathway GO:0030509 9.8 TGFB3 TGFB2 TGFB1 BMP4 BMP2
40 cardiac muscle cell differentiation GO:0055007 9.79 ITGB1 BMP4 BMP2
41 cell-cell junction organization GO:0045216 9.78 TGFB3 TGFB2 TGFB1
42 positive regulation of bone mineralization GO:0030501 9.78 TGFB3 TGFB1 BMP4 BMP2
43 pulmonary valve morphogenesis GO:0003184 9.77 TGFB2 BMP4
44 positive regulation of ossification GO:0045778 9.77 TGFB2 BMP4 BMP2
45 positive regulation of SMAD protein signal transduction GO:0060391 9.77 TGFB3 TGFB1 BMP4
46 SMAD protein signal transduction GO:0060395 9.77 TGFB3 TGFB2 TGFB1 BMP4 BMP2
47 basement membrane organization GO:0071711 9.76 NID1 ITGB1
48 secondary palate development GO:0062009 9.76 TGFB3 TGFB2
49 positive regulation of fibroblast migration GO:0010763 9.76 TGFB1 ITGB1
50 cardiac right ventricle morphogenesis GO:0003215 9.76 TGFB2 BMP4

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.8 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
2 cytokine activity GO:0005125 9.7 TGFB3 TGFB2 TGFB1 IL1A CXCL8 BMP4
3 transforming growth factor beta receptor binding GO:0005160 9.58 TGFB3 TGFB2 TGFB1
4 type II transforming growth factor beta receptor binding GO:0005114 9.54 TGFB3 TGFB2 TGFB1
5 BMP receptor binding GO:0070700 9.52 BMP4 BMP2
6 co-receptor binding GO:0039706 9.51 BMP4 BMP2
7 type I transforming growth factor beta receptor binding GO:0034713 9.49 TGFB3 TGFB1
8 urea transmembrane transporter activity GO:0015204 9.48 AQP9 AQP3
9 water transmembrane transporter activity GO:0005372 9.46 AQP9 AQP1
10 glycerol channel activity GO:0015254 9.43 AQP9 AQP3
11 type III transforming growth factor beta receptor binding GO:0034714 9.43 TGFB3 TGFB2 TGFB1
12 channel activity GO:0015267 9.35 MIP AQP9 AQP4 AQP3 AQP1
13 water channel activity GO:0015250 9.02 MIP AQP9 AQP4 AQP3 AQP1

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
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