Aliases & Classifications for Bullous Keratopathy

MalaCards integrated aliases for Bullous Keratopathy:

Name: Bullous Keratopathy 12 54 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11031
ICD9CM 34 371.23
NCIt 49 C26970
SNOMED-CT 67 57207003
ICD10 32 H18.1
UMLS 71 C0155111

Summaries for Bullous Keratopathy

MalaCards based summary : Bullous Keratopathy is related to keratopathy and corneal disease, and has symptoms including swelling of eye An important gene associated with Bullous Keratopathy is TNC (Tenascin C), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Bevacizumab and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and bone, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 Bullous keratopathy, also known as pseudophakic bullous keratopathy (PBK), is a pathological condition... more...

Related Diseases for Bullous Keratopathy

Diseases related to Bullous Keratopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 keratopathy 31.4 NID1 IL1A IGF1 CXCL8 BMP4
2 corneal disease 30.6 TGFB2 IL1A DCN CXCL8
3 intraocular pressure quantitative trait locus 30.1 TGFB2 MIP FBN1 BMP4 AQP4 AQP1
4 cataract 29.4 TGFB3 TGFB2 MIP IGF1 FBN1 CXCL8
5 myopia 28.5 TGFB2 TGFB1 IGF1 FBN1 DCN BMP2
6 corneal edema 10.8
7 corneal dystrophy, fuchs endothelial, 1 10.6
8 macular retinal edema 10.5
9 astigmatism 10.5
10 hydrops, lactic acidosis, and sideroblastic anemia 10.5
11 keratitis, hereditary 10.5
12 fuchs' endothelial dystrophy 10.5
13 keratoconus 10.4
14 fuchs' heterochromic uveitis 10.4 TGFB2 CXCL8
15 macular degeneration, age-related, 1 10.3
16 loeys-dietz syndrome 5 10.3 TGFB3 TGFB2 FBN1
17 loeys-dietz syndrome 10.3 TGFB3 TGFB2 FBN1
18 corneal dystrophy 10.3
19 refractive error 10.3
20 heritable thoracic aortic disease 10.3 TGFB3 TGFB2 FBN1
21 aortic disease 10.3 TGFB3 TGFB2 FBN1
22 loeys-dietz syndrome 3 10.3 TGFB3 TGFB2 FBN1
23 loeys-dietz syndrome 4 10.3 TGFB3 TGFB2 FBN1
24 toxicodendron dermatitis 10.3 SELE CXCL8
25 loeys-dietz syndrome 1 10.3 TGFB3 TGFB2 FBN1
26 neonatal marfan syndrome 10.3 FBN1 DCN
27 familial thoracic aortic aneurysm and dissection 10.3 TGFB3 TGFB2 FBN1
28 iritis 10.3
29 corneal ulcer 10.3
30 aneurysm 10.3 TGFB3 TGFB2 FBN1
31 acute transverse myelitis 10.3 CXCL8 AQP4
32 mitral valve disease 10.2 TGFB3 TGFB2 FBN1
33 aortic aneurysm, familial thoracic 1 10.2 TGFB3 TGFB2 FBN1
34 nickel allergic contact dermatitis 10.2 SELE AQP3
35 subependymoma 10.2 AQP4 AQP1
36 aphthous stomatitis 10.2 SELE IL1A CXCL8
37 retinal detachment 10.2
38 yemenite deaf-blind hypopigmentation syndrome 10.2
39 suppression amblyopia 10.2
40 amblyopia 10.2
41 corneal neovascularization 10.2
42 herpes simplex 10.2
43 endotheliitis 10.2
44 leptospirosis 10.2 SELE CXCL8 AQP1
45 dysferlinopathy 10.2 MIP AQP4 AQP1
46 contact dermatitis 10.2 SELE IL1A CXCL8
47 proteasome-associated autoinflammatory syndrome 1 10.2 SELE IL1A CXCL8
48 oligohydramnios 10.1 AQP9 AQP3 AQP1
49 3-methylglutaconic aciduria, type iii 10.1
50 werner syndrome 10.1

Comorbidity relations with Bullous Keratopathy via Phenotypic Disease Network (PDN):


Corneal Degeneration Corneal Edema
Corneal Endothelial Dystrophy Corneal Ulcer

Graphical network of the top 20 diseases related to Bullous Keratopathy:



Diseases related to Bullous Keratopathy

Symptoms & Phenotypes for Bullous Keratopathy

UMLS symptoms related to Bullous Keratopathy:


swelling of eye

MGI Mouse Phenotypes related to Bullous Keratopathy:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.39 AQP1 AQP2 AQP3 AQP4 AQP9 BMP4
2 cardiovascular system MP:0005385 10.38 AQP1 AQP3 AQP4 BMP2 BMP4 FBN1
3 homeostasis/metabolism MP:0005376 10.38 AQP1 AQP2 AQP3 AQP4 AQP9 BMP2
4 growth/size/body region MP:0005378 10.34 AQP1 AQP2 AQP3 AQP4 BMP2 BMP4
5 hematopoietic system MP:0005397 10.34 AQP1 AQP2 AQP4 AQP9 BMP2 BMP4
6 immune system MP:0005387 10.23 AQP3 AQP4 AQP9 BMP2 DCN FBN1
7 mortality/aging MP:0010768 10.22 AQP1 AQP2 AQP3 AQP4 BMP2 BMP4
8 endocrine/exocrine gland MP:0005379 10.19 AQP1 AQP4 BMP4 DCN FBN1 IGF1
9 craniofacial MP:0005382 10.16 AQP3 BMP2 BMP4 DCN FBN1 TGFB1
10 digestive/alimentary MP:0005381 10.15 AQP3 AQP4 BMP2 BMP4 DCN TGFB1
11 hearing/vestibular/ear MP:0005377 10.11 AQP1 AQP3 AQP4 BMP2 BMP4 IGF1
12 nervous system MP:0003631 10.11 AQP1 AQP4 BMP2 BMP4 FBN1 IGF1
13 renal/urinary system MP:0005367 10.02 AQP1 AQP2 AQP3 AQP4 BMP4 DCN
14 limbs/digits/tail MP:0005371 9.98 AQP9 BMP2 BMP4 FBN1 IGF1 TGFB2
15 reproductive system MP:0005389 9.96 AQP1 AQP2 BMP2 BMP4 DCN FBN1
16 respiratory system MP:0005388 9.9 AQP1 AQP3 AQP4 BMP4 DCN FBN1
17 skeleton MP:0005390 9.7 AQP1 AQP3 AQP9 BMP2 BMP4 DCN
18 vision/eye MP:0005391 9.36 AQP1 AQP3 AQP4 BMP4 DCN MIP

Drugs & Therapeutics for Bullous Keratopathy

Drugs for Bullous Keratopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2 Anesthetics Phase 2
3 Endothelial Growth Factors Phase 2
4 Angiogenesis Inhibitors Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Mitogens Phase 2
7
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
8
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 1 83-88-5 493570
9 Trace Elements Phase 1
10 Vitamins Phase 1
11 Micronutrients Phase 1
12 Nutrients Phase 1
13 Vitamin B Complex Phase 1
14 Vitamin B2 Phase 1
15 Vitamin B9 Phase 1
16 Dermatologic Agents Phase 1
17 Folate Phase 1
18 Photosensitizing Agents Phase 1
19 Pharmaceutical Solutions Phase 1
20 Ophthalmic Solutions Phase 1
21 Alkylating Agents
22 Mitomycins
23 Anti-Bacterial Agents
24 Antibiotics, Antitubercular
25 Antitubercular Agents
26 Anti-Infective Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Comparative Analysis of Human Amniotic Membrane Graft Versus Contact Lenses in Syntomathic Bullous Keratopathy Completed NCT01926535 Phase 2
2 Evaluation of the Pain and Visual Outcome Associated With Location of Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
3 Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking in Eyes With Refractory Corneal Infection Completed NCT02068430 Phase 1 Riboflavin 0.1%
4 Phase 1 Clinical Study to Evaluate Safety and Tolerability of Magnetic Human Corneal Endothelial Cells in the Treatment of Corneal Edema Recruiting NCT04191629 Phase 1
5 Corneal Transplantation Guided by OCT RESCAN: Pre-op, Intra-op and Post-op Evaluation Unknown status NCT02736877
6 Prospective, Randomized Crossover Study Of The Hyper-CL™ Lens (Hyper Osmotic Contact Lens) In Subjects Suffering From Corneal Edema Unknown status NCT01890252 saline solution
7 Study of the Effects of Riboflavin/ Ultraviolet-A Corneal Cross-linking Completed NCT01106274
8 Amniotic Membrane and Anterior Stromal Puncture: a Comparative Study in the Treatment of Symptomatic Bullous Keratopathy Completed NCT00659308
9 Amniotic Membrane Transplant in Symptomatic Bullous Keratopathy Patients: Confocal Microscopy & AS-OCT Long Term Results Completed NCT03450954
10 Study of Automated Lamellar Keratectomy With a New Option in Treatment in Symptomatic Patients With Bullous Keratopathy. Completed NCT00654888 Mitomycin
11 The SNEC DSAEK EndoGlide Clinical Trial Completed NCT01122043
12 Prospective, Randomized Crossover Study of Using the Hyper-CL™ Lens (Hyper Osmotic Contact Lens) in Subjects Suffering From Corneal Edema Completed NCT02660151 Salt solution
13 To Investigate the Precision and Agreement of SS-1000 and the Predicate Device Pentacam in a Repeatability and Reproducibility Trial (PASP) Completed NCT02077790
14 Prospective, Randomized Multi-Center Study of Using the Hyper-CL™ Lens in Subjects Suffering From Bacterial Keratitis Recruiting NCT03845374
15 Keratoconus, Corneal Diseases and Transplant Registry (KCDTR) Not yet recruiting NCT04164407

Search NIH Clinical Center for Bullous Keratopathy

Genetic Tests for Bullous Keratopathy

Anatomical Context for Bullous Keratopathy

MalaCards organs/tissues related to Bullous Keratopathy:

40
Endothelial, Eye, Bone, Skin, T Cells, Cortex, Colon

Publications for Bullous Keratopathy

Articles related to Bullous Keratopathy:

(show top 50) (show all 1372)
# Title Authors PMID Year
1
Differential expression of transforming growth factor-beta isoforms in bullous keratopathy corneas. 54 61
20142847 2010
2
Interleukin-1alpha downregulates extracellular-superoxide dismutase in human corneal keratoconus stromal cells. 54 61
17679946 2007
3
Insulin-like growth factor-I (IGF-I) and transforming growth factor-beta (TGF-beta) modulate tenascin-C and fibrillin-1 in bullous keratopathy stromal cells in vitro. 54 61
14550395 2003
4
Increased expression of tenascin-C-binding epithelial integrins in human bullous keratopathy corneas. 54 61
11668187 2001
5
Decorin and biglycan of normal and pathologic human corneas. 54 61
9727420 1998
6
Expression of tenascin-C splice variants in normal and bullous keratopathy human corneas. 54 61
9620072 1998
7
Novel splice variants of human tenascin-C mRNA identified in normal and bullous keratopathy corneas. 54 61
9603390 1998
8
Increased expression of fibrillin-1 in human corneas with bullous keratopathy. 54 61
9603388 1998
9
Tenascin-cytotactin (TN-C) variants in pseudophakic/aphakic bullous keratopathy corneas. 54 61
9850274 1998
10
Detection of mRNA for the cytokines, interleukin-1 alpha and interleukin-8, in corneas from patients with pseudophakic bullous keratopathy. 54 61
7657553 1995
11
Immunosuppressive properties of cultured human cornea and ciliary body in normal and pathological conditions. 54 61
7582904 1995
12
Suprachoroidal Hemorrhage During Descemet Membrane Endothelial Keratoplasty. 61
31714406 2020
13
Five-Year Graft Survival and Clinical Outcomes of 500 Consecutive Cases After Descemet Membrane Endothelial Keratoplasty. 61
31478948 2020
14
Risk Factors for the Development of Ocular Hypertension After Keratoplasty: A Systematic Review. 61
31764288 2020
15
Optimisation of Storage and Transportation Conditions of Cultured Corneal Endothelial Cells for Cell Replacement Therapy. 61
32015414 2020
16
Decreased epithelial to corneal thickness ratio in healthy fellow eyes of patients with unilateral bullous keratopathy. 61
31000511 2020
17
Unusual aetiology of keratitis in a patient with bullous keratopathy. 61
31383374 2020
18
Hybrid Descemet Membrane Endothelial Keratoplasty (H-DMEK): results of a donor insertion pull-through technique using donor stroma as carrier. 61
31949091 2020
19
Graft Detachment After Descemet's Stripping Automated Endothelial Keratoplasty in Bullous Keratopathy and Fuchs Dystrophy. 61
31976339 2020
20
SURVEY OF CLINICAL OPHTHALMIC DISEASE IN THE GIANT PANDA (AILUROPODA MELANOLEUCA) AMONG NORTH AMERICAN ZOOLOGICAL INSTITUTIONS. 61
31926513 2020
21
Densitometry Analysis of Corneal Backscatter After Pre-Descemet Endothelial Keratoplasty for Pseudophakic Bullous Keratopathy. 61
31498248 2020
22
Graft Survival After Penetrating and Endothelial Keratoplasty in Iridocorneal Endothelial Syndrome. 61
31335531 2020
23
Management of pseudophakic bullous keratopathy with ultrathin Descemet stripping automated endothelial keratoplasty and modified Yamanes' technique of scleral fixation. 61
31856506 2020
24
Descemet Membrane Endothelial Keratoplasty With a Pull-Through Insertion Device: Surgical Technique, Endothelial Cell Loss, and Early Clinical Results. 61
31996538 2020
25
[Keratoplasty in Germany: Systematic Analysis of the Quality Reports of German Hospitals between 2006 and 2017]. 61
31968370 2020
26
Clinical Evaluation of the "Lifeline Suture" Technique for DSAEK in Cases Without Posterior Capsule Using a Novel Donor Insertion Device. 61
31809287 2019
27
A prospective, randomized clinical study comparing accelerated corneal collagen crosslinking with 5% NaCl hypertonic saline for bullous keratopathy in Asian eyes. 61
31860972 2019
28
Case Reports for Topical Treatment of Corneal Ulcers with a New Matrix Therapy Agent or RGTA® in Dogs. 61
31847217 2019
29
Management of Nocardia Interface Keratitis After Descemet Membrane Endothelial Keratoplasty. 61
31306288 2019
30
Effect of surgical indication and preoperative lens status on Descemet membrane endothelial keratoplasty outcomes. 61
31863726 2019
31
Corneal nerves in health and disease. 61
31075321 2019
32
Does Preoperative or Postoperative Graft Thickness Influence Postoperative Visual Acuity in Descemet Stripping Automated Endothelial Keratoplasty for Advanced Pseudophakic Bullous Keratopathy? 61
31436644 2019
33
Descemet Membrane Endothelial Keratoplasty Versus Descemet Stripping Automated Endothelial Keratoplasty and Penetrating Keratoplasty. 61
31228467 2019
34
Comparison of 5-Year Clinical Results of Descemet and Non-Descemet Stripping Automated Endothelial Keratoplasty. 61
31789922 2019
35
NS Endo-Inserter: A New Graft Inserter for Descemet Stripping Automated Endothelial Keratoplasty. 61
31403531 2019
36
Reversal of laser in situ keratomileusis interface fluid after Descemet stripping automated endothelial keratoplasty for pseudophakic bullous keratopathy. 61
31546548 2019
37
Primary Bullous Keratopathy in a Patient With Werner Syndrome Treated With Corneal Transplant. 61
29534662 2019
38
Glaucoma Drainage Devices and Reasons For Keratoplasty. 61
31393312 2019
39
Infectious crystalline keratopathy: Management of three cases with different risk factors. 61
31920455 2019
40
Six-Month Results of Descemet Membrane Endothelial Keratoplasty in 100 Eyes: First Clinical Results from Turkey 61
31650789 2019
41
Intraocular lens explantation in Spain: indications and outcomes at a tertiary referral center from 2010 to 2018. 61
31565759 2019
42
Clinical Evaluation of the NS Endo-Inserter, a Novel Donor Inserter for Descemet's Stripping Automated Endothelial Keratoplasty. 61
31762768 2019
43
Comparative analysis of biomechanical parameters of the corneas following Descemet membrane endothelial keratoplasty and contralateral healthy corneas. 61
31187244 2019
44
Five-Year Outcomes of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty. 61
31246680 2019
45
Differential effects of primary disease and corneal vascularisation on corneal transplant rejection and survival. 61
31462418 2019
46
Colonization of therapeutic contact lens by dematiaceous fungi. 61
30981660 2019
47
Indications and techniques of corneal transplantation in a referral center in Colombia, South America (2012-2016). 61
30047076 2019
48
Microkeratome-assisted ultrathin Descemet's stripping automated endothelial keratoplasty: A randomized trial comparing single-pass versus double-pass technique. 61
31332110 2019
49
Anterior Chamber Rebubbling With Perfluoropropane (C3F8) After Failed Rebubbling Attempts for Persistent Descemet Membrane Endothelial Keratoplasty Graft Detachments. 61
31107285 2019
50
Changing Indications for Corneal Transplantations in Southern Taiwan From 2008 to 2018. 61
31313699 2019

Variations for Bullous Keratopathy

Expression for Bullous Keratopathy

Search GEO for disease gene expression data for Bullous Keratopathy.

Pathways for Bullous Keratopathy

Pathways related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 TNC TGFB3 TGFB2 TGFB1 IL1A IGF1
2
Show member pathways
13.55 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
3
Show member pathways
13.41 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
4
Show member pathways
13.29 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
5
Show member pathways
13.11 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
6
Show member pathways
13.05 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
7
Show member pathways
13.05 TNC TGFB3 TGFB2 TGFB1 IGF1 FBN1
8 12.85 TGFB3 TGFB2 TGFB1 IGF1 CXCL8 BMP4
9 12.77 TGFB3 TGFB2 TGFB1 IL1A IGF1
10
Show member pathways
12.66 TGFB3 TGFB2 TGFB1 IL1A IGF1 BMP4
11
Show member pathways
12.48 TGFB3 TGFB2 TGFB1 BMP4 BMP2
12
Show member pathways
12.46 TNC TGFB3 TGFB2 TGFB1 NID1 FBN1
13
Show member pathways
12.43 MIP AQP9 AQP4 AQP3 AQP2 AQP1
14
Show member pathways
12.41 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
15 12.31 TGFB2 TGFB1 IGF1 DCN
16
Show member pathways
12.26 TGFB3 TGFB2 TGFB1 IL1A
17
Show member pathways
12.25 TGFB3 TGFB2 TGFB1 IGF1
18 12.24 TGFB3 TGFB2 TGFB1 BMP4
19 12.23 TGFB3 TGFB2 TGFB1 IL1A
20 12.2 TGFB3 TGFB2 TGFB1 IL1A CXCL8
21 12.18 TGFB3 TGFB2 TGFB1 BMP4 BMP2
22
Show member pathways
12.18 TGFB3 TGFB2 TGFB1 IL1A IGF1 CXCL8
23
Show member pathways
12.09 TGFB3 TGFB2 TGFB1 IGF1
24 12.07 TGFB1 IGF1 BMP4 BMP2
25 12 TGFB1 IL1A CXCL8 AQP4 AQP1
26 11.94 TGFB3 TGFB2 TGFB1 CXCL8
27 11.93 TGFB1 IL1A IGF1 CXCL8 BMP2
28 11.88 TGFB3 TGFB2 TGFB1 SELE IL1A CXCL8
29 11.87 TGFB3 TGFB2 TGFB1
30 11.87 TNC TGFB3 TGFB2 TGFB1
31 11.84 TGFB3 TGFB2 TGFB1 IL1A CXCL8
32 11.79 IGF1 BMP4 BMP2
33 11.76 TGFB3 TGFB2 TGFB1 IGF1
34 11.75 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
35 11.74 AQP9 AQP4 AQP1
36 11.74 TGFB3 TGFB2 TGFB1 BMP4 BMP2
37 11.69 TGFB2 TGFB1 IGF1
38
Show member pathways
11.67 SELE IL1A CXCL8
39 11.67 TGFB1 IGF1 CXCL8
40 11.66 TGFB3 TGFB2 TGFB1
41 11.65 NID1 IGF1 CXCL8
42 11.61 TNC TGFB3 TGFB2 TGFB1 DCN
43 11.6 TGFB2 SELE CXCL8
44
Show member pathways
11.6 TGFB3 TGFB2 TGFB1 FBN1 BMP4 BMP2
45 11.57 TGFB3 TGFB2 TGFB1
46 11.57 TGFB1 IGF1 BMP4
47 11.55 TGFB3 TGFB1 IGF1 BMP4
48 11.53 TGFB3 TGFB2 TGFB1 SELE CXCL8
49 11.5 TGFB3 TGFB2 TGFB1 IGF1
50 11.48 AQP4 AQP3 AQP2

GO Terms for Bullous Keratopathy

Cellular components related to Bullous Keratopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.77 TNC TGFB1 NID1 FBN1 DCN
2 extracellular region GO:0005576 9.77 TNC TGFB3 TGFB2 TGFB1 NID1 IL1A
3 basolateral plasma membrane GO:0016323 9.72 AQP9 AQP4 AQP3 AQP2 AQP1
4 collagen-containing extracellular matrix GO:0062023 9.7 TNC TGFB3 TGFB2 TGFB1 NID1 FBN1
5 basement membrane GO:0005604 9.58 TNC NID1 FBN1
6 platelet alpha granule lumen GO:0031093 9.56 TGFB3 TGFB2 TGFB1 IGF1
7 extracellular space GO:0005615 9.4 TNC TGFB3 TGFB2 TGFB1 SELE IL1A

Biological processes related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.27 TGFB3 TGFB1 IL1A IGF1 DCN BMP4
2 transmembrane transport GO:0055085 10.18 MIP AQP9 AQP4 AQP3 AQP2 AQP1
3 positive regulation of cell proliferation GO:0008284 10.15 TNC TGFB3 TGFB2 TGFB1 IGF1 BMP4
4 inflammatory response GO:0006954 10.11 TGFB1 SELE IL1A CXCL8 BMP2
5 positive regulation of gene expression GO:0010628 10.1 TNC TGFB1 IL1A IGF1 BMP4 BMP2
6 negative regulation of cell proliferation GO:0008285 10.1 TGFB3 TGFB2 TGFB1 IL1A CXCL8 BMP4
7 positive regulation of cell migration GO:0030335 10.06 TGFB1 IGF1 BMP4 BMP2
8 regulation of apoptotic process GO:0042981 10.06 TGFB3 TGFB2 TGFB1 BMP4 BMP2
9 negative regulation of gene expression GO:0010629 10.06 TGFB2 TGFB1 IGF1 BMP4 BMP2
10 extracellular matrix organization GO:0030198 10.05 TNC NID1 FBN1 DCN
11 cellular protein metabolic process GO:0044267 10.05 TNC IGF1 FBN1 BMP4
12 regulation of cell proliferation GO:0042127 10.03 TNC TGFB3 TGFB2 TGFB1
13 heart development GO:0007507 10.03 TGFB2 TGFB1 FBN1 BMP4 BMP2
14 response to hypoxia GO:0001666 10.01 TGFB3 TGFB2 TGFB1 BMP2
15 skeletal system development GO:0001501 9.99 TGFB2 IGF1 FBN1 BMP4 BMP2
16 platelet degranulation GO:0002576 9.98 TGFB3 TGFB2 TGFB1 IGF1
17 kidney development GO:0001822 9.97 TGFB2 FBN1 DCN BMP4
18 transforming growth factor beta receptor signaling pathway GO:0007179 9.95 TGFB3 TGFB2 TGFB1
19 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.94 TGFB2 IGF1 DCN
20 neutrophil chemotaxis GO:0030593 9.94 TGFB2 IL1A CXCL8
21 protein homotetramerization GO:0051289 9.93 MIP AQP4 AQP2
22 neural tube closure GO:0001843 9.93 TGFB2 TGFB1 BMP4
23 response to wounding GO:0009611 9.93 TNC TGFB2 TGFB1
24 cellular response to growth factor stimulus GO:0071363 9.92 TGFB1 BMP4 BMP2
25 wound healing GO:0042060 9.92 TNC TGFB3 TGFB2 TGFB1 DCN
26 negative regulation of epithelial cell proliferation GO:0050680 9.91 TGFB2 TGFB1 BMP4
27 positive regulation of epithelial cell proliferation GO:0050679 9.91 TGFB1 IGF1 BMP4
28 positive regulation of osteoblast differentiation GO:0045669 9.9 IGF1 BMP4 BMP2
29 odontogenesis of dentin-containing tooth GO:0042475 9.9 TNC BMP4 BMP2
30 inner ear development GO:0048839 9.9 TGFB3 TGFB2 TGFB1 BMP2
31 positive regulation of fibroblast proliferation GO:0048146 9.89 TGFB1 IGF1 AQP1
32 negative regulation of cell cycle GO:0045786 9.88 TGFB1 BMP4 BMP2
33 response to progesterone GO:0032570 9.88 TGFB3 TGFB2 TGFB1
34 positive regulation of cell division GO:0051781 9.88 TGFB3 TGFB2 TGFB1 IL1A
35 BMP signaling pathway GO:0030509 9.88 TGFB3 TGFB2 TGFB1 BMP4 BMP2
36 chondrocyte differentiation GO:0002062 9.86 TGFB1 BMP4 BMP2
37 epithelial to mesenchymal transition GO:0001837 9.86 TGFB2 TGFB1 BMP2
38 positive regulation of bone mineralization GO:0030501 9.85 TGFB3 TGFB1 BMP4 BMP2
39 regulation of MAPK cascade GO:0043408 9.85 TGFB3 TGFB2 TGFB1 BMP4 BMP2
40 renal water homeostasis GO:0003091 9.84 AQP4 AQP3 AQP2 AQP1
41 SMAD protein signal transduction GO:0060395 9.83 TGFB3 TGFB2 TGFB1 BMP4 BMP2
42 positive regulation of collagen biosynthetic process GO:0032967 9.81 TGFB3 TGFB1 BMP4
43 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.81 TGFB2 TGFB1 BMP4 BMP2
44 cell-cell junction organization GO:0045216 9.8 TGFB3 TGFB2 TGFB1
45 cell development GO:0048468 9.8 TGFB3 TGFB2 TGFB1 BMP4 BMP2
46 positive regulation of ossification GO:0045778 9.79 TGFB2 BMP4 BMP2
47 pathway-restricted SMAD protein phosphorylation GO:0060389 9.79 TGFB2 TGFB1 BMP2
48 positive regulation of SMAD protein signal transduction GO:0060391 9.78 TGFB3 TGFB1 BMP4
49 negative regulation of immune response GO:0050777 9.77 TGFB2 TGFB1
50 pulmonary valve morphogenesis GO:0003184 9.77 TGFB2 BMP4

Molecular functions related to Bullous Keratopathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.85 TGFB3 TGFB2 TGFB1 IGF1 BMP4 BMP2
2 cytokine activity GO:0005125 9.7 TGFB3 TGFB2 TGFB1 IL1A CXCL8 BMP4
3 transforming growth factor beta receptor binding GO:0005160 9.65 TGFB3 TGFB2 TGFB1 BMP4 BMP2
4 type II transforming growth factor beta receptor binding GO:0005114 9.61 TGFB3 TGFB2 TGFB1
5 water transmembrane transporter activity GO:0005372 9.58 AQP9 AQP2 AQP1
6 co-receptor binding GO:0039706 9.54 BMP4 BMP2
7 type I transforming growth factor beta receptor binding GO:0034713 9.52 TGFB3 TGFB1
8 BMP receptor binding GO:0070700 9.51 BMP4 BMP2
9 type III transforming growth factor beta receptor binding GO:0034714 9.5 TGFB3 TGFB2 TGFB1
10 urea transmembrane transporter activity GO:0015204 9.49 AQP9 AQP3
11 glycerol channel activity GO:0015254 9.48 AQP9 AQP3
12 glycerol transmembrane transporter activity GO:0015168 9.46 AQP2 AQP1
13 channel activity GO:0015267 9.43 MIP AQP9 AQP4 AQP3 AQP2 AQP1
14 water channel activity GO:0015250 9.1 MIP AQP9 AQP4 AQP3 AQP2 AQP1

Sources for Bullous Keratopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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