Aliases & Classifications for Burn Scar

MalaCards integrated aliases for Burn Scar:

Name: Burn Scar 38

Summaries for Burn Scar

MalaCards based summary : Burn Scar is related to scar contracture and squamous cell carcinoma. An important gene associated with Burn Scar is FAS (Fas Cell Surface Death Receptor), and among its related pathways/superpathways are MAPK signaling pathway and Chks in Checkpoint Regulation. The drugs Pharmaceutical Solutions and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and spinal cord, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Burn Scar

Diseases related to Burn Scar via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 scar contracture 10.6
2 squamous cell carcinoma 10.5
3 melanoma 10.5
4 burns 10.3
5 sarcoma 10.2
6 malignant fibroxanthoma 10.2
7 histiocytoma 10.2
8 fibrous histiocytoma 10.2
9 basal cell carcinoma 1 10.2
10 basal cell carcinoma 10.2
11 calcinosis 10.1
12 cowpox 10.1 CASP1 FAS
13 lattice corneal dystrophy 10.1 FAS TGFB1
14 keloids 10.1 FAS TGFB1
15 epithelial basement membrane dystrophy 10.1 FAS TGFB1
16 nodular goiter 10.1 CALCA FAS
17 diabetic foot ulcers 10.0 CALCA TGFB1
18 craniodiaphyseal dysplasia 10.0 CALCA TGFB1
19 silicosis 10.0 FAS TGFB1
20 pneumoconiosis 10.0 FAS TGFB1
21 calcific tendinitis 10.0 TGFB1 UCHL1
22 neuroma 10.0 CALCA TGFB1
23 dermatofibrosarcoma protuberans 10.0
24 alopecia 10.0
25 anaplastic large cell lymphoma 10.0
26 lymphoma 10.0
27 fibrosarcoma 10.0
28 verrucous carcinoma 10.0
29 epithelioid sarcoma 10.0
30 herpes simplex 10.0
31 lupus erythematosus 10.0
32 primary cutaneous anaplastic large cell lymphoma 10.0
33 myxofibrosarcoma 10.0
34 discoid lupus erythematosus 10.0
35 parathyroid carcinoma 10.0 CALCA UCHL1
36 vasomotor rhinitis 9.9 CALCA TAC1
37 autonomic nervous system disease 9.9 CALCA TAC1
38 diffuse pulmonary fibrosis 9.9 CALCA TAC1
39 hashimoto thyroiditis 9.9 CALCA FAS
40 brachial plexus lesion 9.9 CALCA TAC1
41 causalgia 9.9 CALCA TAC1
42 complex regional pain syndrome 9.9 CALCA TAC1
43 hemiplegia 9.9 CALCA TAC1
44 indeterminate leprosy 9.9 TAC1 UCHL1
45 carpal tunnel syndrome 9.9 TAC1 TGFB1
46 alternating hemiplegia of childhood 9.8 CALCA TAC1
47 breast adenocarcinoma 9.8 CALCA FAS
48 constipation 9.8 CALCA TAC1
49 lichen sclerosus et atrophicus 9.8
50 torticollis 9.8

Graphical network of the top 20 diseases related to Burn Scar:



Diseases related to Burn Scar

Symptoms & Phenotypes for Burn Scar

GenomeRNAi Phenotypes related to Burn Scar according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.53 CASP1 FAS TGFB1 UCHL1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.53 CASP1 FAS TGFB1 UCHL1

MGI Mouse Phenotypes related to Burn Scar:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 CASP1 FAS TAC1 TGFB1 UCHL1
2 digestive/alimentary MP:0005381 9.46 CASP1 FAS TGFB1 UCHL1
3 integument MP:0010771 9.35 CASP1 FAS TAC1 TGFB1 UCHL1
4 renal/urinary system MP:0005367 9.02 CASP1 FAS TAC1 TGFB1 UCHL1

Drugs & Therapeutics for Burn Scar

Drugs for Burn Scar (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 1, Phase 2
2
Lidocaine Approved, Vet_approved Early Phase 1,Not Applicable 137-58-6 3676
3
Racepinephrine Approved Early Phase 1 329-65-7 838
4
Ethanol Approved Early Phase 1,Not Applicable 64-17-5 702
5
Epinephrine Approved, Vet_approved Early Phase 1 51-43-4 5816
6
Propranolol Approved, Investigational 525-66-6 4946
7 Mydriatics Early Phase 1
8 Sodium Channel Blockers Early Phase 1
9 Vasoconstrictor Agents Early Phase 1
10 Epinephryl borate Early Phase 1
11 Diuretics, Potassium Sparing Early Phase 1
12 Autonomic Agents Early Phase 1
13 Adrenergic beta-Agonists Early Phase 1
14 Respiratory System Agents Early Phase 1
15 Anti-Asthmatic Agents Early Phase 1
16 Sympathomimetics Early Phase 1
17 Anti-Arrhythmia Agents Early Phase 1
18 Peripheral Nervous System Agents Early Phase 1
19 Anesthetics Early Phase 1,Not Applicable
20 Adrenergic Agonists Early Phase 1
21 Bronchodilator Agents Early Phase 1
22 Neurotransmitter Agents Early Phase 1
23 Anesthetics, Local Early Phase 1
24 Adrenergic alpha-Agonists Early Phase 1
25 Central Nervous System Depressants Early Phase 1
26 Adrenergic Agents Early Phase 1
27 Mitogens Not Applicable
28 Emollients Not Applicable
29 Anesthetics, General Not Applicable
30 Anti-Inflammatory Agents
31 Endothelial Growth Factors
32 Adrenergic beta-Antagonists
33 Adrenergic Antagonists
34 Antihypertensive Agents
35 Vasodilator Agents
36 Specific substance maruyama Not Applicable

Interventional clinical trials:

(show all 50)
# Name Status NCT ID Phase Drugs
1 An Acellular Epithelial Skin Substitute in Deep Partial-thickness Burns Completed NCT01454310 Phase 4
2 Clinical Efficacy and Safety of Autologous Cultured Keratinocyte Cell on Severe Burn Wood Unknown status NCT00978705 Phase 3 Autologous cultured keratinocyte cell
3 Autologous Engineered Skin Substitutes for Closure of Skin Wounds Terminated NCT00591513 Phase 2, Phase 3
4 Skin Substitutes in Burn Care Terminated NCT00676013 Phase 2, Phase 3
5 Use of Pressure Garments for Burn Scars Withdrawn NCT00675974 Phase 2, Phase 3
6 Intron A for the Treatment of Hypertrophic Scar Withdrawn NCT00686478 Phase 3 interferon alpha 2b
7 Perforator Based Interposition Plasty Completed NCT01409759 Phase 2
8 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
9 Pilot Study of Azficel-T for the Treatment of Restrictive Burn Scars Terminated NCT01858753 Phase 2
10 A Clinical Study of Allogeneic Human Dermal Fibroblasts for Remodeling Scar Contractures Terminated NCT01564407 Phase 1, Phase 2 ICX‐RHY‐013
11 Pilot Safety and Efficacy Study of Isolagen Therapy in Treatment of Restrictive Burn Scars Withdrawn NCT00620737 Phase 2
12 Fractional Photothermolysis for the Treatment of Burn Scars Unknown status NCT01005992 Phase 1
13 Gene Expression During Surgical Scar Remodeling by Fractional Photothermolysis Unknown status NCT01858038 Phase 1
14 A Study to Evaluate the Safety of ALLO-ASC-DFU in the Subjects With Deep Second-degree Burn Wound Completed NCT02394873 Phase 1
15 Fractional Nonablative 1540 nm Laser Resurfacing for Burn Scars- A Randomised Controlled Trial Unknown status NCT00689650 Not Applicable
16 Laser Therapy for Treating Hypertrophic Burn Scars in Children Unknown status NCT01653691 Not Applicable
17 Reducing Side-effects of Autologous Skin Tissue Harvesting Unknown status NCT02234193 Early Phase 1
18 The Effects of Therapeutic Resources on Structure and Function of Normal and Burned Skin Unknown status NCT02185950 Not Applicable
19 Nanofat in Post Burn Scars on the Face Completed NCT03352297 Not Applicable
20 Fat Grafting in Skin-grafted Deep Burn Scars Completed NCT03627650 Not Applicable
21 Burn Scar Appearance After Treatment With Fractional Carbon Dioxide (CO2) Laser Completed NCT00969215 Not Applicable
22 Non Ablative Fractional Laser Treatment of Burn Scars Completed NCT02014298 Not Applicable
23 Fractionated Carbon Dioxide Laser and Burn Scar Contractures: Evaluation of Post-Treatment Scar Function and Appearance Completed NCT02115646 Not Applicable
24 Fractional Microplasma Radiofrequency Technology for Non-hypertrophic Post-burn Scars in Asians: A Prospective Study of 95 Patients Completed NCT02861248 Not Applicable
25 The Relationship of Rehabilitation Therapy Time To The Prevention of Burn Scar Contracture Completed NCT01161810
26 Efficacy of Different Densities of Fractional Carbon Dioxide in Treatment of Post Burn Scars Completed NCT03416660 Not Applicable
27 Carbon Dioxide Laser Treatment in Burn-related Scarring Completed NCT03433664 Not Applicable
28 A Follow-up Study to Evaluate the Safety of ALLO-ASC-DFU in ALLO-ASC-BI-101 Clinical Trial Completed NCT03183622
29 Easy Way of Choosing Rectangular Expander and Getting Maximum Benefit From Expanded Tissue Completed NCT03544697
30 EktoTherix™ Regenerative Tissue Scaffold for Repair of Surgical Excision Wounds Completed NCT02409628 Not Applicable
31 Off Label Use of Propranolol for Infancy Hemangiomas Completed NCT01211080 Propranolol
32 CO2 Laser Phototherapy for Management of Mature Burn Scars Recruiting NCT03197649 Not Applicable
33 The Role of Fractional Vascular Laser Therapy in the Management of Burn Scars Recruiting NCT01619917 Not Applicable
34 The Role of Pulsed Dye Laser Therapy in the Management of Burn Scars Recruiting NCT01488240 Not Applicable
35 Laser Therapy for Pediatric Burn Scars Recruiting NCT02707627 Not Applicable
36 Evaluation of the Product Properties of Individualized 3D-compression Garments to Treat Scars Recruiting NCT03664505 Not Applicable
37 Endermotherapy With Burn Hypertrophic Scars Recruiting NCT03697447 Not Applicable
38 Cutaneous Microcirculation After Plasma Therapy Recruiting NCT02417818 Not Applicable
39 Cutaneous Microcirculation After Extracorporeal Shock Wave Therapy Recruiting NCT02417779 Not Applicable
40 A Prospective Trial of Virtual Home Rehabilitation After Burn Injury Recruiting NCT03475654 Not Applicable
41 Ablative Fractional Laser for Sclerotic GVHD-Associated Joint Contractures Active, not recruiting NCT02881047 Not Applicable
42 A Follow-up Study to Evaluate the Safety of ALLO-ASC-DFU in ALLO-ASC-BI-201 Clinical Trial Enrolling by invitation NCT03183648
43 Randomized Control Trial of CO2 Laser to Treat Hypertrophic Burn Scar Not yet recruiting NCT03692273 Not Applicable
44 Feasibility Study - The Place of Surgical Management by Fatty Autograft in Patients With Healed Pelvic Eschar. Interest in Secondary Prevention. Not yet recruiting NCT03669406 Not Applicable
45 Joint Range of Motion in Burn Scars Terminated NCT01034813
46 Study of the Cutaneous Reinnervation After Burn Terminated NCT02356354 Not Applicable
47 UVA1 Light for Scleroderma and Similar Conditions Terminated NCT00476697 Not Applicable
48 Efficacy of Spray Silicone in Alteration of Burn Scar Withdrawn NCT01075165 Not Applicable
49 Study of Silicone Material Inserts To Treat Burn Scars Withdrawn NCT03159182 Not Applicable
50 Laser Induced Bioengineered Remodeling of Thermally Injured Skin Trial Withdrawn NCT02655211 Not Applicable

Search NIH Clinical Center for Burn Scar

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Burn Scar cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Burn Scar:
Laviv azficel-T, dermal fibroblasts for scarring
Embryonic/Adult Cultured Cells Related to Burn Scar:
Skin-derived fibroblasts PMIDs: 21287562 23211390 10805306

Genetic Tests for Burn Scar

Anatomical Context for Burn Scar

MalaCards organs/tissues related to Burn Scar:

41
Skin, Lymph Node, Spinal Cord, Endothelial, Smooth Muscle, Thyroid

Publications for Burn Scar

Articles related to Burn Scar:

(show top 50) (show all 326)
# Title Authors Year
1
Platelet-Rich Plasma Injection in Burn Scar Areas Alleviates Neuropathic Scar Pain. ( 29483815 )
2018
2
Burn Scar Evaluation Using the CutometerAr MPA 580 in Comparison to "Patient and Observer Scar Assessment Scale" and "Vancouver Scar Scale". ( 29596600 )
2018
3
Targeted sequencing of burn scar-related squamous cell carcinomas identified PIK3CA amplification. ( 29941200 )
2018
4
Patient satisfaction after fractional ablation of burn scar with 2940nm wavelength Erbium-Yag laser. ( 29627130 )
2018
5
A Rare Extraskeletal Osteosarcoma Appearing After 55 Years on a Large Stage 3 Burn Scar. ( 29971170 )
2018
6
Risk factors for hypertrophic burn scar pain, pruritus, and paresthesia development. ( 29719102 )
2018
7
Marjolin's Ulcer Arising in a Burn Scar. ( 29596683 )
2018
8
A rare development of basal cell carcinoma on trichoepithelioma in a chemical burn scar tissue: A case report. ( 30235669 )
2018
9
Effect of cold pack therapy for management of burn scar pruritus: A pilot study. ( 29422437 )
2018
10
A case of herpes simplex virus reactivation after fractional ablative carbon dioxide laser to treat a burn scar. ( 30019972 )
2018
11
Expanded Latissimus Dorsi Myocutaneous Flap for Burn Scar Reconstruction. ( 30046368 )
2018
12
Atypical Fibroxanthoma Arising in a Burn Scar Treated With Mohs Micrographic Surgery. ( 30141777 )
2018
13
From a burn scar to malignancy! Marjolin's ulcer, a disease of wound neglect. ( 30151214 )
2018
14
Ten-year Follow-up After Treating Extended Burn Scar Contracture with an Autologous Cultured Dermal Substitute. ( 30276038 )
2018
15
Effect of extracorporeal shock wave therapy on improving burn scar in patients with burnt extremities in Isfahan, Iran. ( 30294349 )
2018
16
Combined Non-Ablative Laser and Microfat Grafting for Burn Scar Treatment. ( 30403775 )
2018
17
Amelanotic desmoplastic melanoma arising on an occipito-parietal burn scar. ( 29050454 )
2017
18
The pedicled groin flap in resurfacing hand burn scar release and other injuries: a five-case series report and review of the literature. ( 28592937 )
2017
19
Thermal Burn Scar-Related Squamous Cell Carcinoma in the Eyelid. ( 28221294 )
2017
20
Below the surface: Parents' views on the factors that influence treatment adherence in paediatric burn scar management - A qualitative study. ( 29031888 )
2017
21
Use of autologous fat grafting for the correction of burn scar contracture in the hand: a case report. ( 28971111 )
2017
22
Psychometric properties of the Brisbane Burn Scar Impact Profile in adults with burn scars. ( 28902874 )
2017
23
Cutaneous osteosarcoma arising from a burn scar. ( 28105506 )
2017
24
Hypertrophic Burn Scar Research: From Quantitative Assessment to Designing Clinical Sequential Multiple Assignment Randomized Trials. ( 28888317 )
2017
25
Automated VSS-based Burn Scar Assessment using Combined Texture and Color Features of Digital Images in Error-Correcting Output Coding. ( 29196632 )
2017
26
Cutaneous Horn Arising From a Burn Scar: A Case Report and Review of Literature. ( 28368921 )
2017
27
Recurrent nonhealing wound in old burn scar may be due to Heterotopic Ossification. ( 28802961 )
2017
28
Effectiveness of topical silicone gel and pressure garment therapy for burn scar prevention and management in children: study protocol for a randomised controlled trial. ( 28209175 )
2017
29
A comparative study of tissue expansion and free parascapular flaps in extensive facial burn scar reconstruction. ( 28804686 )
2017
30
Perforator-based flaps for the treatment of burn scar contractures: a review. ( 28261622 )
2017
31
Perforator-Based Interposition Flaps Perform Better Than Full-Thickness Grafts for the Release of Burn Scar Contractures: A Multicenter Randomized Controlled Trial. ( 28121892 )
2017
32
The neck burn scar contracture: a concept of effective treatment. ( 28717655 )
2017
33
Extension of flaps associated with burn scar reconstruction: A key difference between island and skin-pedicled flaps. ( 29089205 )
2017
34
Impact of a Laser Service Line for Burn Scar on a Dedicated Burn OR's Flow and Productivity. ( 29789856 )
2017
35
Current progress in understanding the molecular pathogenesis of burn scar contracture. ( 28546987 )
2017
36
Ablative fractional CO2 laser for burn scar reconstruction: An extensive subjective and objective short-term outcome analysis of a prospective treatment cohort. ( 27707636 )
2016
37
A systematic review of objective burn scar measurements. ( 27574684 )
2016
38
Extensive Squamous Cell Carcinoma Originating from a Burn Scar: Marjolin's Ulcer with an Unusual Presentation. ( 26848243 )
2016
39
Dermal Remodeling of Burn Scar by Fractional CO2 Laser. ( 27519176 )
2016
40
Malignant Melanoma on a Thermal Burn Scar with an Interval of More Than 70 Years. ( 27721752 )
2016
41
Profile of Patients Without Burn Scar Contracture Development. ( 27505046 )
2016
42
Accuracy of remote burn scar evaluation via live video-conferencing technology. ( 27931764 )
2016
43
Development of International Outcomes Instrument for Hand and Upper Extremity Burn Scar Contracture Release. ( 27532614 )
2016
44
Predictive validity of short term scar quality on final burn scar outcome using the Patient and Observer Scar Assessment Scale in patients with minor to moderate burn severity. ( 28040371 )
2016
45
Effects of pain Scrambler therapy for management of burn scar pruritus: A pilot study. ( 27756587 )
2016
46
Autologous fat grafting does not improve burn scar appearance: A prospective, randomized, double-blinded, placebo-controlled, pilot study. ( 28041747 )
2016
47
The Stanford-ReSurge Burn Scar Contracture Scale for Neck: Development and Initial Validation for Burn Scar Contracture. ( 27783006 )
2016
48
Marjolin's Ulcer in a Post Burn Scar of the Hand. ( 26435998 )
2015
49
Paediatric post-burn scar management in the UK: a national survey. ( 25468478 )
2015
50
Changes in fibrillin-1 expression, elastin expression and skin surface texture at sites of cultured epithelial autograft transplantation onto wounds from burn scar excision. ( 25586891 )
2015

Variations for Burn Scar

Expression for Burn Scar

Search GEO for disease gene expression data for Burn Scar.

Pathways for Burn Scar

GO Terms for Burn Scar

Cellular components related to Burn Scar according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.26 CALCA TAC1 TGFB1 UCHL1
2 axon GO:0030424 8.92 CALCA TAC1 TGFB1 UCHL1

Biological processes related to Burn Scar according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.58 CALCA TAC1 TGFB1
2 neuropeptide signaling pathway GO:0007218 9.52 CALCA TAC1
3 cellular calcium ion homeostasis GO:0006874 9.51 CALCA TGFB1
4 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.49 CASP1 FAS
5 apoptotic signaling pathway GO:0097190 9.48 CASP1 FAS
6 regulation of blood pressure GO:0008217 9.46 CALCA TAC1
7 sensory perception of pain GO:0019233 9.43 TAC1 UCHL1
8 regulation of apoptotic process GO:0042981 9.43 CASP1 FAS TGFB1
9 extrinsic apoptotic signaling pathway GO:0097191 9.37 FAS TGFB1
10 cellular response to nerve growth factor stimulus GO:1990090 9.32 CALCA TAC1
11 negative regulation of ossification GO:0030279 9.16 CALCA TGFB1
12 response to pain GO:0048265 8.96 CALCA TAC1
13 cellular response to mechanical stimulus GO:0071260 8.8 CASP1 FAS TGFB1

Molecular functions related to Burn Scar according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activity GO:0004197 9.16 CASP1 UCHL1
2 kinase binding GO:0019900 8.96 CASP1 FAS
3 identical protein binding GO:0042802 8.92 CALCA CASP1 FAS TGFB1

Sources for Burn Scar

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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