MCID: BRN009
MIFTS: 53

Burning Mouth Syndrome

Categories: Rare diseases, Neuronal diseases, Oral diseases

Aliases & Classifications for Burning Mouth Syndrome

MalaCards integrated aliases for Burning Mouth Syndrome:

Name: Burning Mouth Syndrome 12 76 53 59 44 15 73
Stomatodynia 53 59 73
Stomatopyrosis 12 59
Orodynia 12 59
Bms 53 59
Burning Mouth Disorder 53
Oral Dysesthesia 59

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4331
MeSH 44 D002054
NCIt 50 C62545
SNOMED-CT 68 111349000 399165002
Orphanet 59 ORPHA353253
UMLS via Orphanet 74 C0006430 C2930806
ICD10 via Orphanet 34 K14.6

Summaries for Burning Mouth Syndrome

NIH Rare Diseases : 53 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown. Treatment depends on the symptoms present and aims to control them.

MalaCards based summary : Burning Mouth Syndrome, also known as stomatodynia, is related to trigeminal neuralgia and autonomic nervous system disease, and has symptoms including oral manifestations An important gene associated with Burning Mouth Syndrome is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Regulation of IFNA signaling. The drugs Clonazepam and GABA Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and brain, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 76 Burning mouth syndrome (BMS) is a burning sensation in the mouth with no underlying dental or medical... more...

Related Diseases for Burning Mouth Syndrome

Diseases in the Burning Mouth Syndrome family:

Burning Mouth Syndrome Type 3

Diseases related to Burning Mouth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 218)
# Related Disease Score Top Affiliating Genes
1 trigeminal neuralgia 30.3 SCN9A TRPV1
2 autonomic nervous system disease 30.2 NGF TAC1
3 peripheral nervous system disease 29.4 NGF SCN9A TRPV1
4 aphthous stomatitis 29.1 IL6 MUC7 TNF
5 paine syndrome 28.5 NGF SCN9A TAC1 TRPV1
6 burning mouth syndrome type 3 12.4
7 glossodynia 11.4
8 glossitis 11.2
9 burns 11.1
10 extramedullary plasmacytoma 10.7 IL2 IL6
11 uremic pruritus 10.7 IL2 IL6
12 capillary leak syndrome 10.7 IL2 IL6
13 necrotizing fasciitis 10.7 IL2 IL6
14 scorpion envenomation 10.6 IL6 TNF
15 leukomalacia 10.5 IL6 TNF
16 traumatic brain injury 10.5 IL6 NGF
17 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL6 TNF
18 lesion of sciatic nerve 10.5 NGF TRPV1
19 critical limb ischemia 10.5 IL6 TNF
20 null-cell leukemia 10.5 IL6 TNF
21 oral tuberculosis 10.5 IL2 TNF
22 cough variant asthma 10.5 NGF TRPV1
23 retinitis pigmentosa 55 10.5 IL6 TNF
24 anca-associated vasculitis 10.5 IL6 TNF
25 laryngitis 10.5 IL6 TNF
26 acute vascular insufficiency of intestine 10.5 IL6 TNF
27 posterior urethral valves 10.5 IL6 TNF
28 poems syndrome 10.5 IL6 TNF
29 meconium aspiration syndrome 10.5 IL6 TNF
30 sciatic neuropathy 10.5 NGF TRPV1
31 central nervous system vasculitis 10.5 IL6 TNF
32 autoimmune myocarditis 10.5 IL2 TNF
33 osteosclerotic myeloma 10.5 IL6 TNF
34 stachybotrys chartarum 10.5 IL6 TNF
35 louse-borne relapsing fever 10.5 IL6 TNF
36 listeriosis 10.5 IL6 TNF
37 farmer's lung 10.5 IL2 TNF
38 transverse myelitis 10.5 IL6 TNF
39 ischemic heart disease 10.5 IL6 TNF
40 crimean-congo hemorrhagic fever 10.5 IL6 TNF
41 monoclonal gammopathy of uncertain significance 10.5 IL6 TNF
42 clonorchiasis 10.5 IL2 TNF
43 post-transplant lymphoproliferative disease 10.5 IL6 TNF
44 crohn's colitis 10.5 IL2 TNF
45 eales disease 10.5 IL6 TNF
46 hemorrhagic fever 10.5 IL6 TNF
47 myelitis 10.5 IL6 TNF
48 stromal keratitis 10.5 IL6 TNF
49 endometritis 10.5 IL6 TNF
50 posterior uveitis 10.5 IL2 TNF

Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to Burning Mouth Syndrome

Symptoms & Phenotypes for Burning Mouth Syndrome

UMLS symptoms related to Burning Mouth Syndrome:


oral manifestations

MGI Mouse Phenotypes related to Burning Mouth Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 IL2 IL6 NGF SCN9A TAC1 TNF
2 cardiovascular system MP:0005385 9.43 TRPV1 IL2 IL6 NGF TAC1 TNF
3 integument MP:0010771 9.1 IL6 NGF SCN9A TAC1 TNF TRPV1

Drugs & Therapeutics for Burning Mouth Syndrome

Drugs for Burning Mouth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4,Early Phase 1 1622-61-3 2802
2 GABA Agents Phase 4,Early Phase 1,Not Applicable
3 GABA Modulators Phase 4,Early Phase 1,Not Applicable
4 Neurotransmitter Agents Phase 4,Phase 2,Early Phase 1,Not Applicable
5 Anticonvulsants Phase 4,Early Phase 1,Not Applicable
6
Acetylcholine Approved Phase 2 51-84-3 187
7
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
8 abobotulinumtoxinA Phase 2
9 Central Nervous System Depressants Phase 2,Not Applicable
10 Cholinergic Agents Phase 2
11 Neuromuscular Agents Phase 2
12 Angiogenesis Inhibitors Phase 2
13 onabotulinumtoxinA Phase 2
14 Angiogenesis Modulating Agents Phase 2
15 Peripheral Nervous System Agents Phase 2,Not Applicable
16 Anti-Bacterial Agents Phase 2
17 Pharmaceutical Solutions Phase 2,Not Applicable
18 Immunosuppressive Agents Phase 2
19 Anti-Infective Agents Phase 2
20 Botulinum Toxins, Type A Phase 2
21 Botulinum Toxins Phase 2
22 Anesthetics Phase 2,Not Applicable
23 Anesthetics, Local Phase 2,Not Applicable
24
Iron Approved Not Applicable 7439-89-6 23925
25
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
26
Glycerol Approved, Investigational Not Applicable 56-81-5 753
27
Capsaicin Approved Not Applicable 404-86-4 1548943
28
Tolnaftate Approved, Investigational, Vet_approved Early Phase 1 2398-96-1 5510
29
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
30
Lorazepam Approved Not Applicable 846-49-1 3958
31
gamma-Aminobutyric acid Approved, Investigational Not Applicable 56-12-2 119
32
Nalbuphine Approved Not Applicable 20594-83-6 5360630 5311304
33
Naloxone Approved, Vet_approved Not Applicable 465-65-6 5284596
34
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
35
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
36
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
37
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
38
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
39
Butyric Acid Experimental, Investigational Not Applicable 107-92-6 264
40 Micronutrients Not Applicable
41 Hematinics Not Applicable
42 Trace Elements Not Applicable
43 Vitamin B 12 Not Applicable
44 Vitamin B Complex Not Applicable
45 Vitamins Not Applicable
46 Antibodies Not Applicable
47 Immunoglobulins Not Applicable
48 Autoantibodies Not Applicable
49 Thioctic Acid
50 Dermatologic Agents Not Applicable

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome Withdrawn NCT02690844 Phase 4 Clonazepam mixed with Mucolox®;Mucolox® alone;Clonazepam
2 Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders Completed NCT00374673 Phase 3
3 Botulinum Toxin in Burning Mouth Syndrome Completed NCT02964728 Phase 2 Botulinum Neurotoxin Type A
4 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2 Thalidomide
5 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
6 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
7 Effect of Gluten Free Diet in Patients With Burning Mouth Syndrome Unknown status NCT01867151 Not Applicable
8 Burning Mouth Disorder (BMD) - A Neuropathic Pain Disorder Unknown status NCT00504387
9 The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study Completed NCT01754740 Not Applicable Uréia;Placebo
10 Opiorphin Levels in Fluids of Burning Mouth Syndrome Patients (OPIODYN) Completed NCT02686359 Not Applicable
11 Efficacy of Melatonin in Burning Mouth Syndrome (BMS) Completed NCT02580734 Not Applicable
12 Acupuncture Versus Clonazepam in Burning Mouth Syndrome Completed NCT02382029 Early Phase 1 Clonazepam
13 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
14 Study Evaluating the Laser Diode Effect Burning Mouth Syndrome Completed NCT02757612 Not Applicable
15 Neurogenic Mechanisms in Burning Mouth Syndrome Completed NCT00875537 Not Applicable
16 Alpha Lipoic Acid for Burning Mouth Completed NCT00387543
17 Pain and Sensory Changes Assessment in HIV+ Patients Completed NCT00422695
18 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601 Not Applicable
19 Assessment of Peripheral GABA Receptors for Local Pain Relief Recruiting NCT02928328 Not Applicable GABA oral solution;Intramuscular GABA;Pain modulation
20 Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain Terminated NCT00716807 Not Applicable nalbuphine plus naloxone;nalbuphine plus placebo;nalbuphine plus naloxone;nalbuphine plus placebo

Search NIH Clinical Center for Burning Mouth Syndrome

Cochrane evidence based reviews: burning mouth syndrome

Genetic Tests for Burning Mouth Syndrome

Anatomical Context for Burning Mouth Syndrome

MalaCards organs/tissues related to Burning Mouth Syndrome:

41
Tongue, Testes, Brain, Thyroid, Skin, Colon, Cortex

Publications for Burning Mouth Syndrome

Articles related to Burning Mouth Syndrome:

(show top 50) (show all 497)
# Title Authors Year
1
A successful approach to conrol burning mouth syndrome using matricaria recutita and cognitive therapy. ( 29849976 )
2018
2
An increase in salivary flow with amitriptyline may indicate treatment resistance in burning mouth syndrome. ( 29575764 )
2018
3
The role of psychological factors in the development of burning mouth syndrome. ( 29074062 )
2018
4
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
5
Depression and distress in burning mouth syndrome: A case control study. ( 29460523 )
2018
6
Understanding of Burning Mouth Syndrome Based on Psychological Aspects. ( 29507908 )
2018
7
Clinical characterization and treatment outcome of patients with burning mouth syndrome. ( 29714699 )
2018
8
Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with burning mouth syndrome: Results from a pilot study. ( 29194773 )
2018
9
Melatonin Treatment in Patients with Burning Mouth Syndrome: A Triple-Blind, Placebo-Controlled, Crossover Randomized Clinical Trial. ( 29694465 )
2018
10
Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial. ( 29502160 )
2018
11
Is burning mouth syndrome a neuropathic pain condition? ( 29257770 )
2018
12
A pragmatic evidence-based clinical management algorithm for burning mouth syndrome. ( 29750091 )
2018
13
Mechanical sensitivity and psychological factors in patients with burning mouth syndrome. ( 29777310 )
2018
14
History of burning mouth syndrome (1800-1950): A review. ( 29569416 )
2018
15
Changes in the vibration sensitivity and pressure pain thresholds in patients with burning mouth syndrome. ( 29782537 )
2018
16
Plasma N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: potential role in disease pathogenesis. ( 29436743 )
2018
17
Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome. ( 29917294 )
2018
18
Treatment modalities for burning mouth syndrome: a systematic review. ( 29696421 )
2018
19
Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome. ( 29913093 )
2018
20
Comparison between burning mouth syndrome patients with and without psychological problems. ( 29506949 )
2018
21
Pain-relieving effects of clonazepam and amitriptyline in burning mouth syndrome: a retrospective study. ( 28473243 )
2017
22
Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome. ( 28199919 )
2017
23
A diagnostic and therapeutic approach to primary burning mouth syndrome. ( 28916026 )
2017
24
Functional Alterations of Postcentral Gyrus Modulated by Angry Facial Expressions during Intraoral Tactile Stimuli in Patients with Burning Mouth Syndrome: A Functional Magnetic Resonance Imaging Study. ( 29163243 )
2017
25
Effects of low-level laser therapy on burning mouth syndrome. ( 27893167 )
2017
26
Topical Clonazepam Solution for the Management of Burning Mouth Syndrome: A Retrospective Study. ( 28738111 )
2017
27
Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. ( 29913754 )
2017
28
Comparison of Salivary Cortisol and I+-amylase Levels and Psychological Profiles in Patients with Burning Mouth Syndrome. ( 28112423 )
2017
29
A A9burningA9 therapy for burning mouth syndrome: preliminary results with the administration of topical capsaicin. ( 28691458 )
2017
30
Neuropathic Pain in Patients with Burning Mouth Syndrome Evaluated Using painDETECT. ( 28057813 )
2017
31
"Is it Sjogren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms"-a commentary. ( 29217136 )
2017
32
Botulinum Toxin for Burning Mouth Syndrome. ( 28395302 )
2017
33
Clinical characterization of women with burning mouth syndrome in a case-control study. ( 29284330 )
2017
34
Little evidence to support or refute interventions for the management of burning mouth syndrome. ( 28642559 )
2017
35
RF-Burning Mouth Syndrome: New Treatments. ( 27702434 )
2017
36
A case-control evaluation of fungiform papillae density in burning mouth syndrome. ( 28833164 )
2017
37
Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome. ( 28357703 )
2017
38
The association between Burning Mouth Syndrome and Sleep Disturbance: a case-control multicentre study. ( 29156085 )
2017
39
Effect of Oral Care Gel for Burning Mouth Syndrome in a Patient with Hepatitis C: A Case Report. ( 29033766 )
2017
40
Potential protein biomarkers for burning mouth syndrome discovered by quantitative proteomics. ( 28326926 )
2017
41
Burning Mouth Syndrome: Aetiopathogenesis and Principles of Management. ( 29180911 )
2017
42
Burning mouth syndrome: a systematic review of treatments. ( 28247977 )
2017
43
Online Information on the Treatment of Burning Mouth Syndrome: Quality and Readability. ( 28437511 )
2017
44
Altered structural connectivity of pain-related brain network in burning mouth syndrome-investigation by graph analysis of probabilistic tractography. ( 28361345 )
2017
45
Primary burning mouth syndrome: Literature review and preliminary findings suggesting possible association with pain modulation. ( 29192294 )
2017
46
Chronic Orofacial Pain: Burning Mouth Syndrome and Other Neuropathic Disorders. ( 28638895 )
2017
47
Analgesic effect of topical oral capsaicin gel in burning mouth syndrome. ( 28007005 )
2017
48
"Is it SjAPgren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms"-Response. ( 29153276 )
2017
49
Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences. ( 28972293 )
2017
50
Profiling intraoral neuropathic disturbances following lingual nerve injury and in burning mouth syndrome. ( 28330489 )
2017

Variations for Burning Mouth Syndrome

Expression for Burning Mouth Syndrome

Search GEO for disease gene expression data for Burning Mouth Syndrome.

Pathways for Burning Mouth Syndrome

Pathways related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 IL2 IL6 NGF TNF
2
Show member pathways
12.39 IL2 IL6 TNF
3
Show member pathways
12.29 IL2 IL6 NGF TNF
4
Show member pathways
12.21 IL2 IL6 TNF
5
Show member pathways
12.19 IL2 IL6 TNF
6 12.18 IL2 IL6 TNF
7
Show member pathways
12.04 IL2 IL6 TNF
8
Show member pathways
11.96 IL2 IL6 TNF
9
Show member pathways
11.89 IL2 IL6 TNF
10 11.69 IL2 IL6 TNF
11 11.64 IL2 IL6 TNF
12 11.47 IL6 NGF TAC1 TNF
13 11.37 IL2 IL6 TNF
14 11.31 IL6 TNF
15 11.31 IL2 TNF
16 11.27 IL6 TNF
17
Show member pathways
11.23 IL2 IL6 TNF
18 11.14 IL6 TNF
19 11.13 IL6 TNF
20 11.08 NGF TNF
21 11.07 IL6 TNF
22 11.06 NGF TRPV1
23 11.04 IL6 TNF
24 11.04 IL2 IL6 TNF
25 10.84 IL6 TNF
26 10.74 IL6 TNF
27 10.28 IL2 IL6 TNF

GO Terms for Burning Mouth Syndrome

Cellular components related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 IL2 IL6 NGF TAC1 TNF
2 extracellular region GO:0005576 9.1 IL2 IL6 MUC7 NGF TAC1 TNF

Biological processes related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.73 IL2 IL6 NGF TNF
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.63 IL2 TAC1 TRPV1
3 negative regulation of fat cell differentiation GO:0045599 9.56 IL6 TNF
4 positive regulation of interferon-gamma production GO:0032729 9.55 IL2 TNF
5 positive regulation of nitric oxide biosynthetic process GO:0045429 9.54 TNF TRPV1
6 cellular response to nerve growth factor stimulus GO:1990090 9.52 TAC1 TRPV1
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.51 NGF TNF
8 response to pain GO:0048265 9.49 TAC1 TRPV1
9 positive regulation of chemokine production GO:0032722 9.48 IL6 TNF
10 positive regulation of apoptotic process GO:0043065 9.46 IL6 NGF TNF TRPV1
11 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL6
12 positive regulation of acute inflammatory response GO:0002675 9.37 IL6 TAC1
13 behavioral response to pain GO:0048266 9.32 SCN9A TRPV1
14 negative regulation of lipid storage GO:0010888 9.26 IL6 TNF
15 sensory perception of pain GO:0019233 9.13 SCN9A TAC1 TRPV1
16 inflammatory response GO:0006954 9.02 IL6 SCN9A TAC1 TNF TRPV1

Molecular functions related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL2 IL6 TNF
2 growth factor activity GO:0008083 8.8 IL2 IL6 NGF

Sources for Burning Mouth Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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