BMS
MCID: BRN009
MIFTS: 51

Burning Mouth Syndrome (BMS)

Categories: Neuronal diseases, Oral diseases, Rare diseases, Smell/Taste diseases

Aliases & Classifications for Burning Mouth Syndrome

MalaCards integrated aliases for Burning Mouth Syndrome:

Name: Burning Mouth Syndrome 12 73 20 58 44 15 17 70
Stomatodynia 20 58 70
Stomatopyrosis 12 58
Orodynia 12 58
Bms 20 58
Burning Mouth Disorder 20
Oral Dysesthesia 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4331
MeSH 44 D002054
NCIt 50 C62545
SNOMED-CT 67 111349000
ICD10 via Orphanet 33 K14.6
UMLS via Orphanet 71 C0006430 C2930806
Orphanet 58 ORPHA353253
UMLS 70 C0006430 C2930806

Summaries for Burning Mouth Syndrome

GARD : 20 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown. Treatment depends on the symptoms present and aims to control them.

MalaCards based summary : Burning Mouth Syndrome, also known as stomatodynia, is related to glossitis and neuropathy, and has symptoms including oral manifestations An important gene associated with Burning Mouth Syndrome is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. The drugs Levoleucovorin and Iron have been mentioned in the context of this disorder. Affiliated tissues include tongue, cortex and spinal cord, and related phenotypes are cardiovascular system and integument

Disease Ontology : 12 A mouth disease that is characterized by long-lasting burning sensations of the mouth.

Wikipedia : 73 Burning mouth syndrome (BMS) is a burning sensation in the mouth with no underlying known dental or... more...

Related Diseases for Burning Mouth Syndrome

Diseases related to Burning Mouth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 810)
# Related Disease Score Top Affiliating Genes
1 glossitis 31.8 TNF SLC6A4 IL6 IL1B
2 neuropathy 30.5 TRPV1 TNF SCN9A NGF IL6
3 neutropenia 30.5 TNF IL6 IL2 IL1B CXCL8
4 lichen planus 30.5 TNF IL6 IL2 IL1B CXCL8
5 mental depression 30.4 TNF SLC6A4 IL6 IL1B
6 stomatitis 30.4 TNF IL6 IL2 IL1B CXCL8
7 sensory peripheral neuropathy 30.4 TRPV1 SCN9A NGF
8 somatization disorder 30.3 TAC1 SLC6A4 IL6
9 chickenpox 30.3 TNF IL6 IL2
10 cardiogenic shock 30.3 TNF IL6
11 candidiasis 30.2 TNF TLR2 IL6 IL2 IL1B CXCL8
12 gastritis 30.2 TNF IL6 IL1B CXCL8
13 exanthem 30.2 TNF IL6 IL2 IL1B CXCL8
14 haemophilus influenzae 30.1 TNF TLR2 CXCL8
15 immune deficiency disease 30.1 TNF TLR2 IL6 IL2 IL1B
16 allergic disease 30.0 TNF TLR2 IL6 IL2 IL1B CXCL8
17 anxiety 30.0 TNF TAC1 SLC6A4 NGF IL6 IL1B
18 denture stomatitis 30.0 IL6 CXCL8
19 atrophic gastritis 29.9 TNF IL6 IL1B CXCL8
20 gastroesophageal reflux 29.9 TNF IL6 IL1B CXCL8
21 fatty liver disease 29.8 TNF IL6 IL1B CXCL8
22 pulpitis 29.8 TRPV1 TNF IL6 IL1B CXCL8
23 autoimmune disease 29.8 TNF IL6 IL2 IL1B CXCL8
24 non-alcoholic steatohepatitis 29.7 TNF TLR2 IL6 CXCL8
25 prostatitis 29.7 TNF IL6 IL2 IL1B CXCL8
26 urticaria 29.7 TNF TAC1 IL6 CXCL8
27 graft-versus-host disease 29.7 TNF IL6 IL2 IL1B
28 sleep disorder 29.7 TNF TAC1 SLC6A4 IL6 IL1B CXCL8
29 type 1 diabetes mellitus 29.7 TNF IL6 IL2 IL1B CXCL8
30 dermatitis 29.7 TNF TLR2 IL6 IL2 IL1B CXCL8
31 aphthous stomatitis 29.7 TNF TLR2 IL6 IL2 IL1B CXCL8
32 periodontitis 29.7 TNF TLR2 IL6 IL2 IL1B CXCL8
33 contact dermatitis 29.7 TNF TLR2 NGF IL6 IL2 IL1B
34 major depressive disorder 29.7 TNF TAC1 SLC6A4 NGF IL6 IL1B
35 allergic contact dermatitis 29.6 TNF IL6 IL1B CXCL8 CALCA
36 ileus 29.6 TNF IL6 IL1B CALCA
37 pulmonary edema 29.6 TNF IL1B CXCL8
38 chlamydia 29.6 TNF TLR2 IL6 IL1B CXCL8
39 diabetic neuropathy 29.6 TRPV1 SCN9A NGF CALCA
40 headache 29.6 TAC1 SLC6A4 CALCA
41 meningitis 29.5 TNF TLR2 IL6 IL2 IL1B CXCL8
42 pharyngitis 29.5 TNF IL6 IL1B CXCL8
43 erythema multiforme 29.5 TNF IL6 IL2 CXCL8
44 thyroiditis 29.5 TNF IL6 IL2 IL1B CALCA
45 pulmonary fibrosis, idiopathic 29.5 TNF IL6 IL1B CXCL8
46 myeloma, multiple 29.5 TNF IL6 IL2 IL1B CXCL8
47 bacterial meningitis 29.5 TNF TLR2 IL6 IL1B CXCL8
48 proteasome-associated autoinflammatory syndrome 1 29.5 TNF TLR2 IL6 IL1B CXCL8
49 aspergillosis 29.4 TNF TLR2 IL6 IL1B CXCL8
50 gingivitis 29.4 TNF TLR2 IL6 IL2 IL1B CXCL8

Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to Burning Mouth Syndrome

Symptoms & Phenotypes for Burning Mouth Syndrome

UMLS symptoms related to Burning Mouth Syndrome:


oral manifestations

MGI Mouse Phenotypes related to Burning Mouth Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 IL1B IL2 IL6 NGF P2RX3 SLC6A4
2 integument MP:0010771 9.85 IL1B IL6 NGF P2RX3 SCN9A SLC6A4
3 neoplasm MP:0002006 9.43 IL1B IL2 IL6 TLR2 TNF TRPV1
4 nervous system MP:0003631 9.32 ARTN IL1B IL6 NGF P2RX3 SCN9A

Drugs & Therapeutics for Burning Mouth Syndrome

Drugs for Burning Mouth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levoleucovorin Approved, Investigational Phase 3 68538-85-2 149436
2
Iron Approved Phase 3 7439-89-6 23925 29936
3
Hydroxocobalamin Approved Phase 3 13422-51-0 11953898 15589840
4
Methylcobalamin Approved, Investigational Phase 3 13422-55-4
5
Zinc Approved, Investigational Phase 3 7440-66-6 32051
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
8
Cobalamin Experimental Phase 3 13408-78-1 6857388
9 Vitamin B9 Phase 3
10 Folate Phase 3
11 Vitamins Phase 3
12 Vitamin B Complex Phase 3
13 Vitamin B12 Phase 3
14 Vitamin B 12 Phase 3
15
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
16
Thalidomide Approved, Investigational, Withdrawn Phase 2 50-35-1 5426
17
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
18 Pharmaceutical Solutions Phase 2
19 abobotulinumtoxinA Phase 2
20 Cholinergic Agents Phase 2
21 Botulinum Toxins Phase 2
22 Botulinum Toxins, Type A Phase 2
23 Immunosuppressive Agents Phase 2
24 Angiogenesis Inhibitors Phase 2
25 Anti-Infective Agents Phase 2
26 Immunologic Factors Phase 2
27 Anti-Bacterial Agents Phase 2
28 Anesthetics Phase 2
29 Anesthetics, Local Phase 2
30
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
31
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
32
Lidocaine Approved, Vet_approved 137-58-6 3676
33
Lorazepam Approved 846-49-1 3958
34
Capsaicin Approved 404-86-4 1548943
35
Glycerol Approved, Investigational 56-81-5 753
36
carbamide peroxide Approved 124-43-6
37
Tolnaftate Approved, Investigational, Vet_approved Early Phase 1 2398-96-1 5510
38
Tocopherol Approved, Investigational Early Phase 1 1406-66-2
39
Nalbuphine Approved 20594-83-6 5311304 5360630
40
Naloxone Approved, Vet_approved 465-65-6 5284596
41
Glutamic acid Approved, Nutraceutical 56-86-0 33032
42
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
43
Vitamin E Approved, Nutraceutical, Vet_approved Early Phase 1 59-02-9 14985
44
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Early Phase 1 83-88-5 493570
45
Butyric Acid Experimental, Investigational 107-92-6 264
46 Tocotrienol Investigational Early Phase 1 6829-55-6
47 Anti-Arrhythmia Agents
48 Gastrointestinal Agents
49 Psychotropic Drugs
50 Sodium Channel Blockers

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Use of Low Intensity Laser Combined With Topical Clonazepam for the Treatment of Burning Mouth Syndrome Recruiting NCT04313907 Phase 4 Sham laser plus topical clonazepam
2 Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome Withdrawn NCT02690844 Phase 4 Clonazepam mixed with Mucolox®;Mucolox® alone;Clonazepam
3 Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Idiopathic Pain Syndromes : a Double Blind Sham Controlled Study Completed NCT00374673 Phase 3
4 A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation Not yet recruiting NCT04189367 Phase 3 Traditional Chinese Medicine;Western medicine
5 Botulinum Toxin in Burning Mouth Syndrome Completed NCT02964728 Phase 2 Botulinum Neurotoxin Type A
6 Evaluation of a TNF-Alpha Modulator for the Treatment of Oral Lesions in HIV/AIDS Patients Completed NCT00001524 Phase 2 Thalidomide
7 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Oral Mucosal Pain in Burning Mouth Syndrome, Sjögrens Syndrome and Lichen Planus. Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
8 Vurdering af Perifere GABAA-receptorer Med Henblik på Lokal Smertelindring Unknown status NCT02928328 GABA oral solution;Intramuscular GABA;Pain modulation
9 Burning Mouth Disorder (BMD) - a Neuropathic Pain Disorder? An Investigation Using Qualitative and Quantitative Sensory Testing (QST) Unknown status NCT00504387
10 Effetto Della Dieta Priva di Glutine in Soggetti Con BMS Unknown status NCT01867151
11 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293
12 Study of the Efficacy of Melatonin in the Burning Mouth Syndrome Unknown status NCT03788733 Melatonin 3 mg;Placebo Oral
13 Different Therapeutic Options for Burning Mouth Syndrome Completed NCT04475614
14 Melatonin to Treat Burning Mouth Syndrome (BMS): A Randomized, Cross-over, Placebo-controlled, Triple-blind Clinical Trial Completed NCT02580734
15 Hormonal Status and Quality of Life in Female Postmenopausal Patients With Burning Mouth Syndrome Completed NCT04535973
16 The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study Completed NCT01754740 Uréia;Placebo
17 The Effectiveness of Acupuncture Versus Clonazepam in the Patients With Burning Mouth Syndrome Completed NCT02382029 Early Phase 1 Clonazepam
18 Study Evaluating the Laser Diode Effect on Burning Mouth Syndrome Completed NCT02757612
19 Effects of Photobiomodulation With Low-Level Laser Therapy in Burning Mouth Syndrome: A Randomized Clinical Trial Completed NCT04034849
20 Research of a Biological Marker for Chronic Orofacial Pain: Dosage of Opiorphin in Patients With Burning Mouth Syndrome Completed NCT02686359
21 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
22 Neurogenic Mechanisms in Burning Mouth Syndrome With Focus on Localization and Desensibilization of Vanilloid Receptor TRPV1 Completed NCT00875537
23 Review of Mayo Clinic Experience With Burning Mouth Syndrome - Use of Alpha Lipoic Acid Completed NCT00387543
24 Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities Completed NCT00001601
25 Identification de Voies Physiopathologiques et Cibles thérapeutiques Dans la Stomatodynie Primaire (" Burning Mouth Syndrome ") Par la métabolomique Salivaire : étude Cas/témoins Recruiting NCT04704128
26 Head Yuanshi Dian Therapy in the Treatment of Burning Mouth Syndrome: a Randomized Controlled Trial Recruiting NCT04481841 Early Phase 1 oryzanol + vitamin B2 (riboflavin) + vitamin E
27 Protective Mouth Guards in Burning Mouth Syndrome (Prospective Study) Enrolling by invitation NCT04203134
28 Modeling Kappa Opioid Analgesic Mechanisms in Chronic Orofacial Pain Disorders Terminated NCT00716807 nalbuphine plus naloxone;nalbuphine plus placebo;nalbuphine plus naloxone;nalbuphine plus placebo

Search NIH Clinical Center for Burning Mouth Syndrome

Cochrane evidence based reviews: burning mouth syndrome

Genetic Tests for Burning Mouth Syndrome

Anatomical Context for Burning Mouth Syndrome

MalaCards organs/tissues related to Burning Mouth Syndrome:

40
Tongue, Cortex, Spinal Cord, Thyroid, Skin, Prefrontal Cortex, Amygdala

Publications for Burning Mouth Syndrome

Articles related to Burning Mouth Syndrome:

(show top 50) (show all 975)
# Title Authors PMID Year
1
Catastrophising, pain self-efficacy and acceptance in patients with Burning Mouth Syndrome. 61
33368621 2021
2
Oral cenesthopathy superimposed on burning mouth syndrome treated with aripiprazole: A case report with a phenomenological overview. 61
33586237 2021
3
Correction to: IMMPACT-recommended outcome measures and tools of assessment in burning mouth syndrome RCTs: an international Delphi survey protocol. 61
33752708 2021
4
Effectiveness of photobiomodulation in the treatment of primary burning mouth syndrome-a systematic review and meta-analysis. 61
32725428 2021
5
Developing a research diagnostic criteria for burning mouth syndrome: Results from an international Delphi process. 61
33155292 2021
6
A case of vestibular schwannoma mimicking burning mouth syndrome. 61
33743774 2021
7
Efficacy of the laser at low intensity on primary burning oral syndrome: a systematic review. 61
33609024 2021
8
The role of the dentist in the diagnosis and management of patients with oral mucosal diseases. 61
33395400 2021
9
Sphenopalatine ganglion block - a new treatment for burning mouth syndrome?: a case report. 61
33762189 2021
10
Orofacial pain education in dentistry: A path to improving patient care and reducing the population burden of chronic pain. 61
33098113 2021
11
WWOM VII: Effectiveness of systemic pharmacotherapeutic interventions in the management of BMS: A systematic review and meta-analysis. 61
33713052 2021
12
Anemia, hematinic deficiencies, and hyperhomocysteinemia in gastric parietal cell antibody-positive and -negative burning mouth syndrome patients. 61
32888843 2021
13
Oral Psychosomatic Disorders in Family Caregivers of Oral Squamous Cell Carcinoma Patients. 61
33639663 2021
14
Are Oral Mucosal Changes a Sign of COVID-19? A Cross-Sectional Study at a Field Hospital. 61
33652010 2021
15
The impact on quality of life in patients with burning mouth syndrome: A systematic review and meta-analysis. 61
33353825 2021
16
Saliva flow rates and clinical characteristics of patients with burning mouth syndrome: A case-control study. 61
33640241 2021
17
Evaluating the Suitability and Potential Efficiency of Cannabis sativa Oil for Patients with Primary Burning Mouth Syndrome: A Prospective, Open-Label, Single-Arm Pilot Study. 61
33123730 2021
18
Chemosensory Function in Burning Mouth Syndrome a Comparative Cross-Sectional Study. 61
33668711 2021
19
Oral health-related quality of life and associated factors in patients with burning mouth syndrome. 61
33031643 2021
20
Differences in personality, perceived stress and physical activity in women with burning mouth syndrome compared to controls. 61
33108343 2021
21
The Association between Emotional Stress, Sleep Disturbance, Depression, and Burning Mouth Syndrome. 61
33791363 2021
22
Are Patch Test Results Usually Relevant in Patients With Burning Mouth Syndrome? 61
33002454 2021
23
Careful use of clonazepam and alpha lipoid acid in burning mouth syndrome treatment. 61
33440037 2021
24
Burning mouth syndrome - quality of life. 61
33483666 2021
25
Evaluation of patients suffered from burning mouth syndrome and persistent idiopathic facial pain using Japanese version PainDETECT questionnaire and depression scales. 61
33384789 2021
26
Anatomically Coiled Internal Carotid Artery Resulting in Severe Dysphagia and Burning Mouth Syndrome. 61
33333198 2020
27
Effects of cognitive behavioral therapy on orofacial pain conditions. 61
33298629 2020
28
Multifactor analysis of patients with oral sensory complaints in a case-control study. 61
33273331 2020
29
Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome. 61
32883568 2020
30
Psychophysical characterisation of burning mouth syndrome-A systematic review and meta-analysis. 61
32500929 2020
31
Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome. 61
33295074 2020
32
Burning Mouth Syndrome Induced by Angiotensin-Converting Enzyme Inhibitors. 61
33312778 2020
33
Clinical presentation of burning mouth syndrome in patients with oral lichenoid disease. 61
32851991 2020
34
Probiotics-A complete oral healthcare package. 61
32907783 2020
35
Effects of photobiomodulation with low-level laser therapy in burning mouth syndrome: A randomized clinical trial. 61
32460396 2020
36
Evaluation of IL-6 levels and +3954 polymorphism of IL-1β in burning mouth syndrome: A systematic review and meta-analysis. 61
32274841 2020
37
Altered pain modulation to noxious heat thermal stimuli in burning mouth syndrome. 61
32531814 2020
38
Evaluation of the efficacy of treatment modalities in burning mouth syndrome-A systematic review. 61
32979878 2020
39
Thermal quantitative sensory testing in burning mouth syndrome. 61
33063218 2020
40
Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome. 61
33098162 2020
41
Health-related quality of life in burning mouth syndrome - a case-control study. 61
32853174 2020
42
Photobiomodulation Dose Parameters in Dentistry: A Systematic Review and Meta-Analysis. 61
33036145 2020
43
Burning Mouth Syndrome. 61
32892856 2020
44
Salivary Hormones and Quality of Life in Female Postmenopausal Burning Mouth Patients-A Pilot Case-Control Study. 61
33019769 2020
45
Acute and cumulative benefits of Photobiomodulation for xerostomia: A systematic review and meta-analysis. 61
32964596 2020
46
Real-world Discontinuation of Antidepressant Treatment in Patients with Burning Mouth Syndrome: A Chart Review. 61
31841160 2020
47
Analgesic effect of gum chewing in patients with burning mouth syndrome. 61
32893197 2020
48
Photobiomodulation Therapy in the Management of Burning Mouth Syndrome: Morphological Variations in the Capillary Bed. 61
32882863 2020
49
Effect of a Homemade Salivary Substitute Prepared Using Chamomile (Matricaria chamomilla L.) Flower and Flax (Linum usitatissimum L.) Seed to Relieve Primary Burning Mouth Syndrome: A Preliminary Report. 61
32924561 2020
50
The association between burning mouth syndrome and urologic chronic pelvic pain syndrome: A case-control study. 61
32797728 2020

Variations for Burning Mouth Syndrome

Expression for Burning Mouth Syndrome

Search GEO for disease gene expression data for Burning Mouth Syndrome.

Pathways for Burning Mouth Syndrome

Pathways related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.38 TNF TLR2 NGF IL6 IL2 IL1B
2
Show member pathways
13.26 TNF NGF IL6 IL2 IL1B CXCL8
3
Show member pathways
13.17 TNF TLR2 IL6 IL2 IL1B CXCL8
4
Show member pathways
12.96 TNF TLR2 NGF IL6 IL2
5
Show member pathways
12.91 TNF TLR2 IL6 IL1B CXCL8
6
Show member pathways
12.83 TNF IL6 IL2 IL1B CXCL8
7
Show member pathways
12.79 TNF TLR2 IL6 IL2 IL1B CXCL8
8
Show member pathways
12.73 TNF TLR2 IL6 IL1B CXCL8
9
Show member pathways
12.7 TNF TLR2 IL6 IL1B CXCL8
10
Show member pathways
12.66 TNF TLR2 NGF IL6 IL2 IL1B
11
Show member pathways
12.58 TNF TLR2 IL6 IL2 IL1B
12
Show member pathways
12.57 TNF TLR2 IL6 IL2 IL1B
13
Show member pathways
12.56 TNF IL6 IL2 IL1B
14
Show member pathways
12.56 TNF TLR2 NGF IL1B
15 12.54 TNF TLR2 IL2 IL1B
16
Show member pathways
12.33 TNF IL6 IL2 CXCL8
17
Show member pathways
12.32 TNF IL6 IL2 IL1B
18
Show member pathways
12.32 TNF TLR2 IL6 IL1B CXCL8
19
Show member pathways
12.3 TNF IL6 IL1B CXCL8
20
Show member pathways
12.26 TNF TLR2 IL6 CXCL8
21 12.23 TNF IL6 IL1B CXCL8
22 12.22 TNF TLR2 IL6 IL1B
23
Show member pathways
12.22 TNF NGF IL6 IL2 IL1B CXCL8
24
Show member pathways
12.19 TNF IL6 IL2 IL1B
25
Show member pathways
12.16 TNF TLR2 IL6 IL1B CXCL8
26 12.03 TNF IL6 IL2 IL1B CXCL8
27 11.98 TNF IL6 IL1B CXCL8
28 11.97 TNF IL6 IL2
29 11.95 TNF IL6 IL1B
30 11.95 TNF IL6 IL2 IL1B CXCL8
31 11.92 IL6 IL1B CXCL8
32 11.91 TNF IL1B CXCL8
33 11.91 TNF IL6 IL1B CXCL8
34 11.89 TNF IL6 IL1B
35 11.86 TNF TLR2 IL6 IL1B CXCL8
36
Show member pathways
11.84 TLR2 IL6 IL1B
37 11.8 IL6 IL2 CXCL8
38 11.78 TNF IL2 IL1B
39 11.77 TNF TLR2 IL6 IL1B CXCL8
40
Show member pathways
11.76 TNF IL2 CXCL8
41 11.76 TNF IL6 IL1B CXCL8
42 11.74 TNF IL6 IL2 IL1B
43 11.69 TNF TLR2 IL6
44
Show member pathways
11.65 TNF TLR2 IL6 IL2 IL1B
45 11.56 TNF IL6 IL2
46 11.52 TNF TLR2 IL1B
47 11.52 TNF IL2 IL1B
48 11.52 TNF IL6 IL1B CXCL8
49
Show member pathways
11.52 TNF IL6 IL2 IL1B CXCL8
50
Show member pathways
11.46 TNF SLC6A4 IL1B

GO Terms for Burning Mouth Syndrome

Cellular components related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.65 TRPV1 SLC6A4 SCN9A P2RX3 CALCA
2 membrane raft GO:0045121 9.62 TNF TLR2 SLC6A4 P2RX3
3 extracellular space GO:0005615 9.61 TNF TAC1 NGF IL6 IL2 IL1B
4 axon GO:0030424 9.55 TAC1 SCN9A P2RX3 NGF CALCA
5 extracellular region GO:0005576 9.32 TNF TAC1 NGF MUC7 IL6 IL2

Biological processes related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 10.04 TLR2 NGF IL6 IL1B CXCL8
2 MAPK cascade GO:0000165 9.98 TNF IL2 IL1B ARTN
3 cell-cell signaling GO:0007267 9.96 TAC1 IL2 IL1B CALCA
4 immune response GO:0006955 9.95 TNF TLR2 IL6 IL2 IL1B CXCL8
5 cytokine-mediated signaling pathway GO:0019221 9.92 TNF IL6 IL2 IL1B CXCL8
6 cellular response to lipopolysaccharide GO:0071222 9.91 TNF IL6 IL1B CXCL8
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 TNF TLR2 IL6 IL1B
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 TRPV1 TAC1 IL2 CALCA
9 positive regulation of DNA-binding transcription factor activity GO:0051091 9.88 TNF IL6 IL1B
10 defense response to Gram-positive bacterium GO:0050830 9.87 TNF TLR2 IL6
11 response to toxic substance GO:0009636 9.86 TLR2 SLC6A4 SCN9A
12 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.86 TNF NGF IL6
13 response to organic substance GO:0010033 9.85 TNF SLC6A4 P2RX3
14 regulation of insulin secretion GO:0050796 9.84 TNF IL6 IL1B
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 TNF IL6 IL2
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 TNF TLR2 IL1B
17 positive regulation of interferon-gamma production GO:0032729 9.83 TNF IL2 IL1B
18 positive regulation of T cell proliferation GO:0042102 9.82 IL6 IL2 IL1B
19 sensory perception of pain GO:0019233 9.81 TRPV1 TAC1 SCN9A
20 positive regulation of inflammatory response GO:0050729 9.8 TNF TLR2 IL2 IL1B
21 response to heat GO:0009408 9.79 TRPV1 P2RX3 CALCA
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 TRPV1 TNF IL1B
23 cellular response to nerve growth factor stimulus GO:1990090 9.76 TRPV1 TAC1 CALCA
24 positive regulation of interleukin-6 production GO:0032755 9.76 TNF TLR2 IL6 IL1B
25 positive regulation of chemokine production GO:0032722 9.75 TNF TLR2 IL6
26 lipopolysaccharide-mediated signaling pathway GO:0031663 9.72 TNF TLR2 IL1B
27 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 TNF IL1B
28 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 TNF IL1B
29 microglial cell activation GO:0001774 9.71 TRPV1 TNF TLR2
30 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.7 TNF IL6
31 induction of positive chemotaxis GO:0050930 9.7 CXCL8 ARTN
32 positive regulation of acute inflammatory response GO:0002675 9.7 TAC1 IL6
33 positive regulation of gene expression GO:0010628 9.7 TNF TLR2 SLC6A4 NGF IL6 IL1B
34 negative regulation of heart rate GO:0010459 9.69 TRPV1 TAC1
35 response to molecule of bacterial origin GO:0002237 9.69 TLR2 CXCL8
36 negative regulation of neurogenesis GO:0050768 9.69 TNF IL6 IL1B
37 regulation of establishment of endothelial barrier GO:1903140 9.67 TNF IL1B
38 negative regulation of lipid storage GO:0010888 9.67 TNF IL6
39 urinary bladder smooth muscle contraction GO:0014832 9.64 TRPV1 P2RX3
40 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
41 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
42 positive regulation of glial cell proliferation GO:0060252 9.61 TNF IL6 IL1B
43 response to pain GO:0048265 9.58 TRPV1 TAC1 CALCA
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 TNF IL1B
45 fever generation GO:0001660 9.56 TRPV1 IL1B
46 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B
47 behavioral response to pain GO:0048266 9.5 TRPV1 SCN9A P2RX3
48 vascular endothelial growth factor production GO:0010573 9.43 TNF IL6 IL1B
49 positive regulation of interleukin-8 production GO:0032757 9.35 TNF TLR2 IL6 IL1B CALCA
50 inflammatory response GO:0006954 9.28 TRPV1 TNF TLR2 TAC1 SCN9A IL6

Molecular functions related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 NGF IL6 IL2 ARTN
2 cytokine activity GO:0005125 9.02 TNF IL6 IL2 IL1B CXCL8

Sources for Burning Mouth Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....