MCID: BRN009
MIFTS: 53

Burning Mouth Syndrome

Categories: Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Burning Mouth Syndrome

MalaCards integrated aliases for Burning Mouth Syndrome:

Name: Burning Mouth Syndrome 12 77 54 60 45 15 17 74
Stomatodynia 54 60 74
Stomatopyrosis 12 60
Orodynia 12 60
Bms 54 60
Burning Mouth Disorder 54
Oral Dysesthesia 60

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4331
MeSH 45 D002054
NCIt 51 C62545
ICD10 via Orphanet 35 K14.6
UMLS via Orphanet 75 C0006430 C2930806
Orphanet 60 ORPHA353253

Summaries for Burning Mouth Syndrome

NIH Rare Diseases : 54 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown. Treatment depends on the symptoms present and aims to control them.

MalaCards based summary : Burning Mouth Syndrome, also known as stomatodynia, is related to glossitis and bone resorption disease, and has symptoms including oral manifestations An important gene associated with Burning Mouth Syndrome is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and NF-KappaB Family Pathway. The drugs Clonazepam and GABA Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue, thyroid and heart, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 77 Burning mouth syndrome (BMS) is a burning sensation in the mouth with no underlying known dental or... more...

Related Diseases for Burning Mouth Syndrome

Diseases related to Burning Mouth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 311)
# Related Disease Score Top Affiliating Genes
1 glossitis 32.5 IL6 TNF
2 bone resorption disease 30.4 IL6 TRPV1
3 ischemic heart disease 30.3 TNF IL6
4 aplastic anemia 30.3 IL6 IL2 TNF
5 trigeminal neuralgia 30.2 SCN9A TRPV1
6 aphthous stomatitis 29.9 IL2 IL6 TNF
7 myeloma, multiple 29.9 IL2 IL6 TNF
8 hematopoietic stem cell transplantation 29.7 IL2 IL6 TNF
9 filariasis 29.7 IL2 IL6 TNF
10 paine syndrome 29.2 NGF SCN9A TAC1 TRPV1
11 peripheral nervous system disease 28.5 IL6 NGF SCN9A TAC1 TNF TRPV1
12 glossodynia 11.5
13 depression 10.4
14 anxiety 10.4
15 extramedullary plasmacytoma 10.3 IL2 IL6
16 herpes zoster 10.3 IL2 TRPV1
17 uremic pruritus 10.3 IL2 IL6
18 capillary leak syndrome 10.3 IL2 IL6
19 necrotizing fasciitis 10.3 IL6 IL2
20 lichen planus 10.3
21 melioidosis 10.3 IL6 TNF
22 chikungunya 10.3 IL6 TNF
23 rheumatic heart disease 10.3 IL6 TNF
24 hemorrhagic fever with renal syndrome 10.3 IL6 TNF
25 pyelonephritis 10.3 IL6 TNF
26 echinococcosis 10.3 IL6 TNF
27 meningoencephalitis 10.3 IL6 TAC1
28 pericarditis 10.3 IL6 TNF
29 leptospirosis 10.3 IL6 TNF
30 opiate dependence 10.3 NGF TRPV1
31 spondylocarpotarsal synostosis syndrome 10.3
32 bacterial vaginosis 10.3 IL6 TNF
33 uveal disease 10.3 IL6 TNF
34 mixed connective tissue disease 10.3 IL6 TNF
35 avian influenza 10.3 IL6 TNF
36 acute respiratory distress syndrome 10.3 IL6 TNF
37 autoimmune uveitis 10.3 IL2 TNF
38 pleurisy 10.3 IL2 TNF
39 oral lichen planus 10.3
40 exanthema subitum 10.3 IL2 IL6
41 testicular disease 10.3 IL2 TNF
42 lymphatic system disease 10.3 IL2 TNF
43 scorpion envenomation 10.3 IL6 TNF
44 leukomalacia 10.3 IL6 TNF
45 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL6 TNF
46 lesion of sciatic nerve 10.3 NGF TRPV1
47 autoimmune myocarditis 10.3 IL6 TNF
48 critical limb ischemia 10.2 IL6 TNF
49 limb ischemia 10.2 IL6 TNF
50 juvenile ankylosing spondylitis 10.2 IL6 TNF

Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to Burning Mouth Syndrome

Symptoms & Phenotypes for Burning Mouth Syndrome

UMLS symptoms related to Burning Mouth Syndrome:


oral manifestations

MGI Mouse Phenotypes related to Burning Mouth Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 IL2 IL6 NGF SCN9A TAC1 TNF
2 cardiovascular system MP:0005385 9.43 IL2 IL6 NGF TAC1 TNF TRPV1
3 integument MP:0010771 9.1 IL6 NGF SCN9A TAC1 TNF TRPV1

Drugs & Therapeutics for Burning Mouth Syndrome

Drugs for Burning Mouth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4,Early Phase 1 1622-61-3 2802
2 GABA Agents Phase 4,Early Phase 1,Not Applicable
3 GABA Modulators Phase 4,Early Phase 1,Not Applicable
4 Neurotransmitter Agents Phase 4,Phase 2,Early Phase 1,Not Applicable
5 Anticonvulsants Phase 4,Early Phase 1,Not Applicable
6
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
7
Bupivacaine Approved, Investigational Phase 2 38396-39-3, 2180-92-9 2474
8 Immunologic Factors Phase 2,Not Applicable
9 Acetylcholine Release Inhibitors Phase 2
10 Pharmaceutical Solutions Phase 2,Not Applicable
11 Neuromuscular Agents Phase 2
12 Botulinum Toxins, Type A Phase 2
13 Cholinergic Agents Phase 2
14 abobotulinumtoxinA Phase 2
15 Botulinum Toxins Phase 2
16 Peripheral Nervous System Agents Phase 2,Not Applicable
17 Anti-Infective Agents Phase 2
18 Anti-Bacterial Agents Phase 2
19 Immunosuppressive Agents Phase 2
20 Angiogenesis Modulating Agents Phase 2
21 Angiogenesis Inhibitors Phase 2
22 Central Nervous System Depressants Phase 2,Not Applicable
23 Anesthetics, Local Phase 2,Not Applicable
24 Anesthetics Phase 2,Not Applicable
25
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
26
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925
27
leucovorin Approved Not Applicable 58-05-9 143 6006
28
Glycerol Approved, Investigational Not Applicable 56-81-5 753
29
carbamide peroxide Approved Not Applicable 124-43-6
30
Tolnaftate Approved, Investigational, Vet_approved Early Phase 1 2398-96-1 5510
31
Capsaicin Approved Not Applicable 404-86-4 1548943
32
Lorazepam Approved Not Applicable 846-49-1 3958
33
gamma-Aminobutyric acid Approved, Investigational Not Applicable 56-12-2 119
34
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
35
Naloxone Approved, Vet_approved Not Applicable 465-65-6 5284596
36
Nalbuphine Approved Not Applicable 20594-83-6 5311304 5360630
37
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
38
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
39
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable 73-31-4 896
40
Glutamic Acid Approved, Nutraceutical Not Applicable 56-86-0 33032
41
Cobalamin Experimental Not Applicable 13408-78-1 6857388
42
Butyric Acid Experimental, Investigational Not Applicable 107-92-6 264
43 Vitamin B12 Not Applicable
44 Vitamins Not Applicable
45 Vitamin B9 Not Applicable
46 Nutrients Not Applicable
47 Antibodies Not Applicable
48 Folate Not Applicable
49 Trace Elements Not Applicable
50 Vitamin B 12 Not Applicable

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome Withdrawn NCT02690844 Phase 4 Clonazepam mixed with Mucolox®;Mucolox® alone;Clonazepam
2 Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders Completed NCT00374673 Phase 3
3 Botulinum Toxin in Burning Mouth Syndrome Completed NCT02964728 Phase 2 Botulinum Neurotoxin Type A
4 Thalidomide to Treat Oral Lesions in HIV-Infected Patients Completed NCT00001524 Phase 2 Thalidomide
5 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Chronic Oral Pain Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
6 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293 Not Applicable
7 Effect of Gluten Free Diet in Patients With Burning Mouth Syndrome Unknown status NCT01867151 Not Applicable
8 Burning Mouth Disorder (BMD) - A Neuropathic Pain Disorder Unknown status NCT00504387
9 The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study Completed NCT01754740 Not Applicable Uréia;Placebo
10 Opiorphin Levels in Fluids of Burning Mouth Syndrome Patients (OPIODYN) Completed NCT02686359 Not Applicable
11 Efficacy of Melatonin in Burning Mouth Syndrome (BMS) Completed NCT02580734 Not Applicable
12 Acupuncture Versus Clonazepam in Burning Mouth Syndrome Completed NCT02382029 Early Phase 1 Clonazepam
13 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
14 Study Evaluating the Laser Diode Effect Burning Mouth Syndrome Completed NCT02757612 Not Applicable
15 Neurogenic Mechanisms in Burning Mouth Syndrome Completed NCT00875537 Not Applicable
16 Alpha Lipoic Acid for Burning Mouth Completed NCT00387543
17 Pain and Sensory Changes Assessment in HIV+ Patients Completed NCT00422695
18 Evaluation and Treatment of Oral Soft Tissue Diseases Completed NCT00001601 Not Applicable
19 The Efficacy of Melatonin in the Burning Mouth Syndrome Recruiting NCT03788733 Not Applicable Melatonin 3 mg;Placebo Oral
20 Assessment of Peripheral GABA Receptors for Local Pain Relief Recruiting NCT02928328 Not Applicable GABA oral solution;Intramuscular GABA;Pain modulation
21 Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain Terminated NCT00716807 Not Applicable nalbuphine plus naloxone;nalbuphine plus placebo;nalbuphine plus naloxone;nalbuphine plus placebo

Search NIH Clinical Center for Burning Mouth Syndrome

Cochrane evidence based reviews: burning mouth syndrome

Genetic Tests for Burning Mouth Syndrome

Anatomical Context for Burning Mouth Syndrome

MalaCards organs/tissues related to Burning Mouth Syndrome:

42
Tongue, Thyroid, Heart, Prostate, Lung, Bone, Testes

Publications for Burning Mouth Syndrome

Articles related to Burning Mouth Syndrome:

(show top 50) (show all 555)
# Title Authors Year
1
An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives. ( 30892737 )
2019
2
Somatosensory Profiling of Patients with Burning Mouth Syndrome and Correlations with Psychologic Factors. ( 30893407 )
2019
3
The usefulness of YouTube™ videos as a source of information on Burning Mouth Syndrome. ( 30919986 )
2019
4
The Association between Burning Mouth Syndrome and Level of Thyroid Hormones in Hashimotos Thyroiditis in Public Hospitals in Shiraz, 2016. ( 30937336 )
2019
5
A case of burning mouth syndrome leading to suicide 10 days after self-cutting of tongue. ( 30957297 )
2019
6
Corneal Confocal Microscopy Detects Small-Fiber Neuropathy in Burning Mouth Syndrome: A Cross-Sectional Study. ( 31017984 )
2019
7
Is there an association between drugs and burning mouth syndrome? a case-control study. ( 31066953 )
2019
8
History of burning mouth syndrome (1800-1950): A review. ( 29569416 )
2019
9
Mechanical sensitivity and psychological factors in patients with burning mouth syndrome. ( 29777310 )
2019
10
Eugenol allergy mimicking burning mouth syndrome. ( 30238469 )
2019
11
Efficacy of ultramicronized palmitoylethanolamide in burning mouth syndrome-affected patients: a preliminary randomized double-blind controlled trial. ( 30361792 )
2019
12
Burning mouth syndrome-a diagnostic dilemma. ( 30603879 )
2019
13
Effectiveness of Pregabalin for Treatment of Burning Mouth Syndrome. ( 30690951 )
2019
14
Visual Imagery: A Tool to Explore the Impact of Burning Mouth Syndrome. ( 30703179 )
2019
15
Current management strategies for the pain of elderly patients with burning mouth syndrome: a critical review. ( 30733824 )
2019
16
Change in gray matter volume and cerebral blood flow in patients with burning mouth syndrome. ( 30735586 )
2019
17
World Workshop on Oral Medicine VII: Burning Mouth Syndrome: A Systematic Review of Disease Definitions and Diagnostic Criteria Utilized in Randomized Clinical Trials. ( 30785661 )
2019
18
Neurophysiology and genetics of burning mouth syndrome. ( 30793423 )
2019
19
Low-level laser therapy in patients with Burning Mouth Syndrome: A double-blind, randomized, controlled clinical trial. ( 30805121 )
2019
20
Add-on administration of ultramicronized palmitoylethanolamide in the treatment of new-onset burning mouth syndrome. ( 30858732 )
2019
21
Burning mouth syndrome triggered by cinnamal present in a denture fixative cream. ( 30864169 )
2019
22
Burning mouth syndrome: a review of etiology, diagnosis, and management. ( 30875303 )
2019
23
Proteomic profiling of whole-saliva reveals correlation between Burning Mouth Syndrome and the neurotrophin signaling pathway. ( 30886243 )
2019
24
Burning mouth syndrome: The challenge of an aging population. ( 30548780 )
2018
25
Anxiety and Depression Scores in Patients with Burning Mouth Syndrome. ( 30439807 )
2018
26
175 Burning Mouth Syndrome Equivalent to Restless Leg Syndrome. ( 30912734 )
2018
27
Burning mouth syndrome: a systematic review of treatments. ( 28247977 )
2018
28
A case-control evaluation of fungiform papillae density in burning mouth syndrome. ( 28833164 )
2018
29
Evaluating Burning Mouth Syndrome as a Comorbidity of Atypical Odontalgia: The Impact on Pain Experiences. ( 28972293 )
2018
30
The role of psychological factors in the development of burning mouth syndrome. ( 29074062 )
2018
31
"Is it Sjögren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms"-Response. ( 29153276 )
2018
32
The association between burning mouth syndrome and sleep disturbance: A case-control multicentre study. ( 29156085 )
2018
33
Plasma IL-8 signature correlates with pain and depressive symptomatology in patients with burning mouth syndrome: Results from a pilot study. ( 29194773 )
2018
34
"Is it Sjogren's syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms"-a commentary. ( 29217136 )
2018
35
Is burning mouth syndrome a neuropathic pain condition? ( 29257770 )
2018
36
Clinical characterization of women with burning mouth syndrome in a case-control study. ( 29284330 )
2018
37
Management of reticular oral lichen planus patients with burning mouth syndrome-like oral symptoms: a pilot study. ( 29308937 )
2018
38
Plasma N-acylethanolamine and endocannabinoid levels in burning mouth syndrome: Potential role in disease pathogenesis. ( 29436743 )
2018
39
Depression and distress in burning mouth syndrome: A case control study. ( 29460523 )
2018
40
Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial. ( 29502160 )
2018
41
Comparison between burning mouth syndrome patients with and without psychological problems. ( 29506949 )
2018
42
Understanding of Burning Mouth Syndrome Based on Psychological Aspects. ( 29507908 )
2018
43
An increase in salivary flow with amitriptyline may indicate treatment resistance in burning mouth syndrome. ( 29575764 )
2018
44
Melatonin Treatment in Patients with Burning Mouth Syndrome: A Triple-Blind, Placebo-Controlled, Crossover Randomized Clinical Trial. ( 29694465 )
2018
45
Treatment modalities for burning mouth syndrome: a systematic review. ( 29696421 )
2018
46
Clinical characterization and treatment outcome of patients with burning mouth syndrome. ( 29714699 )
2018
47
A pragmatic evidence-based clinical management algorithm for burning mouth syndrome. ( 29750091 )
2018
48
Changes in the vibration sensitivity and pressure pain thresholds in patients with burning mouth syndrome. ( 29782537 )
2018
49
A successful approach to conrol burning mouth syndrome using matricaria recutita and cognitive therapy. ( 29849976 )
2018
50
Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome. ( 29913093 )
2018

Variations for Burning Mouth Syndrome

Expression for Burning Mouth Syndrome

Search GEO for disease gene expression data for Burning Mouth Syndrome.

Pathways for Burning Mouth Syndrome

Pathways related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 IL2 IL6 NGF TNF
2
Show member pathways
12.35 IL2 IL6 NGF TNF
3
Show member pathways
12.34 IL2 IL6 TNF
4 12.14 IL2 IL6 TNF
5
Show member pathways
12.08 IL2 IL6 TNF
6
Show member pathways
11.95 IL2 IL6 TNF
7
Show member pathways
11.91 IL2 IL6 NGF TNF
8
Show member pathways
11.78 IL2 IL6 TNF
9 11.73 IL2 IL6 TNF
10 11.7 IL2 IL6 TNF
11 11.5 IL2 IL6 NGF
12 11.47 IL6 NGF TAC1 TNF
13 11.41 IL2 IL6 TNF
14 11.35 IL2 IL6 TNF
15 11.33 IL6 TNF
16 11.32 IL2 TNF
17 11.29 IL6 TNF
18
Show member pathways
11.23 IL2 IL6 TNF
19 11.19 IL6 TNF
20 11.16 IL6 TNF
21 11.11 NGF TNF
22 11.1 IL6 TNF
23 11.1 NGF TRPV1
24 11.08 IL6 TNF
25 11.04 IL2 IL6 TNF
26 10.95 IL2 IL6 TNF
27 10.9 IL6 TNF
28 10.8 IL6 TNF
29 10.71 IL2 IL6 NGF TNF
30 10.26 IL2 IL6 TNF

GO Terms for Burning Mouth Syndrome

Cellular components related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 IL2 IL6 NGF TAC1 TNF
2 extracellular region GO:0005576 9.1 IL2 IL6 MUC7 NGF TAC1 TNF

Biological processes related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 IL2 IL6 TNF
2 regulation of signaling receptor activity GO:0010469 9.76 IL2 IL6 NGF TNF
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.67 IL2 TAC1 TRPV1
4 negative regulation of fat cell differentiation GO:0045599 9.6 IL6 TNF
5 positive regulation of interferon-gamma production GO:0032729 9.59 IL2 TNF
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 TNF TRPV1
7 cellular response to nerve growth factor stimulus GO:1990090 9.57 TAC1 TRPV1
8 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.56 NGF TNF
9 positive regulation of apoptotic process GO:0043065 9.56 IL6 NGF TNF TRPV1
10 negative regulation of neurogenesis GO:0050768 9.55 IL6 TNF
11 positive regulation of chemokine production GO:0032722 9.54 IL6 TNF
12 response to pain GO:0048265 9.52 TAC1 TRPV1
13 microglial cell activation GO:0001774 9.51 TNF TRPV1
14 positive regulation of glial cell proliferation GO:0060252 9.48 IL6 TNF
15 positive regulation of acute inflammatory response GO:0002675 9.43 IL6 TAC1
16 positive regulation of immunoglobulin secretion GO:0051024 9.4 IL2 IL6
17 behavioral response to pain GO:0048266 9.37 SCN9A TRPV1
18 negative regulation of lipid storage GO:0010888 9.32 IL6 TNF
19 positive regulation of neuroinflammatory response GO:0150078 9.16 IL6 TNF
20 sensory perception of pain GO:0019233 9.13 SCN9A TAC1 TRPV1
21 inflammatory response GO:0006954 9.02 IL6 SCN9A TAC1 TNF TRPV1

Molecular functions related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 IL2 IL6 TNF
2 growth factor activity GO:0008083 8.8 IL2 IL6 NGF

Sources for Burning Mouth Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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