BMS
MCID: BRN009
MIFTS: 50

Burning Mouth Syndrome (BMS)

Categories: Neuronal diseases, Oral diseases, Rare diseases

Aliases & Classifications for Burning Mouth Syndrome

MalaCards integrated aliases for Burning Mouth Syndrome:

Name: Burning Mouth Syndrome 12 74 52 58 43 15 17 71
Stomatodynia 52 58 71
Stomatopyrosis 12 58
Orodynia 12 58
Bms 52 58
Burning Mouth Disorder 52
Oral Dysesthesia 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:4331
MeSH 43 D002054
NCIt 49 C62545
SNOMED-CT 67 399165002
ICD10 via Orphanet 33 K14.6
UMLS via Orphanet 72 C0006430 C2930806
Orphanet 58 ORPHA353253
UMLS 71 C0006430 C2930806

Summaries for Burning Mouth Syndrome

NIH Rare Diseases : 52 Burning mouth syndrome is characterized by long-lasting burning sensations of the mouth. The pain may affect the tongue, gums, lips, palate, throat, or the entire mouth. Burning mouth syndrome may be primary or secondary. Experts believe that the primary form may be caused by damage to the nerves that control pain and taste. The secondary form is caused by an underlying medical condition. In many cases, the underlying cause in unknown. Treatment depends on the symptoms present and aims to control them.

MalaCards based summary : Burning Mouth Syndrome, also known as stomatodynia, is related to glossitis and graft-versus-host disease, and has symptoms including oral manifestations An important gene associated with Burning Mouth Syndrome is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Methylcobalamin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include tongue, testes and salivary gland, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 Burning mouth syndrome (BMS) is a burning sensation in the mouth with no underlying known dental or... more...

Related Diseases for Burning Mouth Syndrome

Diseases related to Burning Mouth Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 742)
# Related Disease Score Top Affiliating Genes
1 glossitis 31.8 TNF SLC6A4 IL6 IL1B
2 graft-versus-host disease 30.6 TNF IL6 IL2 IL1B
3 lichen planus 30.4 TNF IL6 IL2 CXCL8
4 filariasis 30.3 TNF IL6 IL2
5 chickenpox 30.3 TNF IL6 IL2
6 candidiasis 30.2 TNF IL6 IL2 IL1B CXCL8
7 haemophilus influenzae 30.2 TNF CXCL8
8 allergic hypersensitivity disease 30.2 TNF TAC1 IL2 CXCL8
9 metal allergy 30.2 TNF IL1B
10 stomatitis 30.1 TNF IL6 IL2 IL1B CXCL8
11 allergic contact dermatitis 30.1 TNF IL6 IL1B CXCL8
12 spinal cord injury 30.0 TNF IL6 CXCL8
13 bone resorption disease 30.0 TNF IL6 IL1B CALCA
14 periodontitis 30.0 TNF IL6 IL1B CXCL8
15 aplastic anemia 30.0 TNF IL6 IL2 IL1B CXCL8
16 bacterial infectious disease 30.0 TNF IL6 IL1B CXCL8
17 myocarditis 29.9 TNF IL6 IL2 IL1B
18 tetanus 29.8 TNF IL6 IL2 IL1B
19 perinatal necrotizing enterocolitis 29.8 TNF IL6 IL1B CXCL8
20 myeloma, multiple 29.8 TNF IL6 IL2 IL1B CXCL8
21 sensory peripheral neuropathy 29.8 TRPV1 TAC1 NGF CALCA
22 brucellosis 29.8 TNF IL6 IL2 CXCL8
23 sleep disorder 29.8 TNF SLC6A4 IL6 IL1B
24 mental depression 29.8 TNF SLC6A4 IL6 IL1B
25 gastritis 29.8 TNF IL6 IL1B CXCL8
26 thyroiditis 29.7 TNF IL6 IL2 CALCA
27 myelodysplastic syndrome 29.7 TNF IL6 IL2 IL1B CXCL8
28 dermatitis 29.7 TNF IL6 IL2 IL1B CXCL8
29 lipoprotein quantitative trait locus 29.7 TNF IL6 IL1B CXCL8
30 gastroesophageal reflux 29.7 TNF IL6 IL1B CXCL8
31 pulmonary edema 29.7 TNF IL1B CXCL8
32 neutropenia 29.6 TNF IL6 IL2 IL1B CXCL8
33 contact dermatitis 29.6 TNF NGF IL6 IL2 IL1B CXCL8
34 somatization disorder 29.6 TAC1 SLC6A4
35 bacterial meningitis 29.6 TNF IL6 IL1B CXCL8
36 viral meningitis 29.6 IL6 CXCL8 CALCA
37 aspergillosis 29.6 TNF IL6 IL1B CXCL8
38 pertussis 29.5 TNF IL6 IL1B CXCL8
39 autoimmune disease 29.5 TNF IL6 IL2 IL1B CXCL8
40 gingivitis 29.5 TNF IL6 IL2 IL1B CXCL8
41 pulpitis 29.5 TRPV1 TNF IL6 IL1B CXCL8
42 paine syndrome 29.5 TRPV1 TAC1 SCN9A P2RX3 NGF IL1B
43 polyneuropathy 29.4 TNF NGF IL6 IL1B CALCA
44 pulmonary fibrosis, idiopathic 29.4 TNF IL6 IL1B CXCL8
45 exanthem 29.3 TNF IL6 IL2 IL1B CXCL8
46 viral infectious disease 29.3 TNF IL6 IL2 IL1B CXCL8
47 leukemia, acute myeloid 29.1 TNF IL6 IL2 IL1B CXCL8
48 skin disease 29.0 TNF TAC1 IL6 IL2 IL1B CXCL8
49 osteomyelitis 29.0 TNF IL6 IL1B CXCL8 CALCA
50 relapsing-remitting multiple sclerosis 29.0 TNF NGF IL6 IL2 IL1B CXCL8

Graphical network of the top 20 diseases related to Burning Mouth Syndrome:



Diseases related to Burning Mouth Syndrome

Symptoms & Phenotypes for Burning Mouth Syndrome

UMLS symptoms related to Burning Mouth Syndrome:


oral manifestations

MGI Mouse Phenotypes related to Burning Mouth Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 CNR1 IL2 IL6 NGF P2RX3 SCN9A
2 cardiovascular system MP:0005385 9.81 IL1B IL2 IL6 NGF P2RX3 SLC6A4
3 integument MP:0010771 9.65 CNR1 IL1B IL6 NGF P2RX3 SCN9A
4 nervous system MP:0003631 9.32 ARTN CNR1 IL1B IL6 NGF P2RX3

Drugs & Therapeutics for Burning Mouth Syndrome

Drugs for Burning Mouth Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylcobalamin Approved, Investigational Phase 3 13422-55-4
2
leucovorin Approved Phase 3 58-05-9 6006 143
3
Zinc Approved, Investigational Phase 3 7440-66-6 32051
4
Hydroxocobalamin Approved Phase 3 13422-51-0 15589840 11953898
5
Iron Approved, Experimental Phase 3 15438-31-0, 7439-89-6 27284 23925
6
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
Cyanocobalamin Approved, Nutraceutical Phase 3 68-19-9 44176380
8
Cobalamin Experimental Phase 3 13408-78-1 6857388
9 Vitamins Phase 3
10 Vitamin B Complex Phase 3
11 Vitamin B 12 Phase 3
12 Folate Phase 3
13 Vitamin B12 Phase 3
14 Vitamin B9 Phase 3
15
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
16
Bupivacaine Approved, Investigational Phase 2 2180-92-9, 38396-39-3 2474
17 abobotulinumtoxinA Phase 2
18 Cholinergic Agents Phase 2
19 Pharmaceutical Solutions Phase 2
20 Botulinum Toxins, Type A Phase 2
21 Botulinum Toxins Phase 2
22 Immunologic Factors Phase 2
23 Angiogenesis Inhibitors Phase 2
24 Immunosuppressive Agents Phase 2
25 Anti-Infective Agents Phase 2
26 Anti-Bacterial Agents Phase 2
27 Anesthetics Phase 2
28 Anesthetics, Local Phase 2
29
Lidocaine Approved, Vet_approved 137-58-6 3676
30
Histamine Approved, Investigational 51-45-6 774
31
gamma-Aminobutyric acid Approved, Investigational 56-12-2 119
32
Lorazepam Approved 846-49-1 3958
33
Capsaicin Approved 404-86-4 1548943
34
Tolnaftate Approved, Investigational, Vet_approved Early Phase 1 2398-96-1 5510
35
Glycerol Approved, Investigational 56-81-5 753
36
carbamide peroxide Approved 124-43-6
37
Naloxone Approved, Vet_approved 465-65-6 5284596
38
Nalbuphine Approved 20594-83-6 5311304 5360630
39
Glutamic acid Approved, Nutraceutical 56-86-0 33032
40
Melatonin Approved, Nutraceutical, Vet_approved 73-31-4 896
41
Butyric Acid Experimental, Investigational 107-92-6 264
42 Trace Elements
43 Immunoglobulins
44 Antibodies
45 Hematinics
46 Nutrients
47 Micronutrients
48 Autoantibodies
49 Sodium Channel Blockers
50 Hypnotics and Sedatives

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 Use of Low Intensity Laser Combined With Topical Clonazepam for the Treatment of Burning Mouth Syndrome Recruiting NCT04313907 Phase 4 Sham laser plus topical clonazepam
2 Effectiveness of Mucolox® and Clonazepam in Treatment of Burning Mouth Syndrome Withdrawn NCT02690844 Phase 4 Clonazepam mixed with Mucolox®;Mucolox® alone;Clonazepam
3 Efficacy of Repetitive Transcranial Magnetic Stimulation in the Treatment of Chronic Idiopathic Pain Syndromes : a Double Blind Sham Controlled Study Completed NCT00374673 Phase 3
4 A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation Not yet recruiting NCT04189367 Phase 3 Traditional Chinese Medicine;Western medicine
5 Botulinum Toxin in Burning Mouth Syndrome Completed NCT02964728 Phase 2 Botulinum Neurotoxin Type A
6 Evaluation of a TNF-Alpha Modulator for the Treatment of Oral Lesions in HIV/AIDS Patients Completed NCT00001524 Phase 2 Thalidomide
7 Clinical Trials With a Local Anesthetic Lozenge for the Treatment of Oral Mucosal Pain in Burning Mouth Syndrome, Sjögrens Syndrome and Lichen Planus. Terminated NCT01584947 Phase 2 Bupivacaine;Placebo
8 Burning Mouth Disorder (BMD) - a Neuropathic Pain Disorder? An Investigation Using Qualitative and Quantitative Sensory Testing (QST) Unknown status NCT00504387
9 Effetto Della Dieta Priva di Glutine in Soggetti Con BMS Unknown status NCT01867151
10 HLA-DRB1 and HLA-DQB1 Genotyping for Autoantibody-positive and -Negative Patients With Atrophic Glossitis or Burning Mouth Syndrome Unknown status NCT01931293
11 Vurdering af Perifere GABAA-receptorer Med Henblik på Lokal Smertelindring Unknown status NCT02928328 GABA oral solution;Intramuscular GABA;Pain modulation
12 Study Evaluating the Laser Diode Effect on Burning Mouth Syndrome Completed NCT02757612
13 Melatonin to Treat Burning Mouth Syndrome (BMS): A Randomized, Cross-over, Placebo-controlled, Triple-blind Clinical Trial Completed NCT02580734
14 A Study of the Association of Sleep Dysfunction and Burning Mouth Syndrome Completed NCT00862576
15 Review of Mayo Clinic Experience With Burning Mouth Syndrome - Use of Alpha Lipoic Acid Completed NCT00387543
16 Research of a Biological Marker for Chronic Orofacial Pain: Dosage of Opiorphin in Patients With Burning Mouth Syndrome Completed NCT02686359
17 Neurogenic Mechanisms in Burning Mouth Syndrome With Focus on Localization and Desensibilization of Vanilloid Receptor TRPV1 Completed NCT00875537
18 The Effectiveness of Acupuncture Versus Clonazepam in the Patients With Burning Mouth Syndrome Completed NCT02382029 Early Phase 1 Clonazepam
19 The Role of Xerostomia in Burning Mouth Syndrome: Case - Control Study Completed NCT01754740 Uréia;Placebo
20 Effects of Photobiomodulation With Low-Level Laser Therapy in Burning Mouth Syndrome: A Randomized Clinical Trial Completed NCT04034849
21 Patient Evaluation and Treatment of Oral Soft Tissue Diseases According to Generally Available, Standard Procedures and Therapeutic Modalities Completed NCT00001601
22 Protective Mouth Guards in Burning Mouth Syndrome (Prospective Study) Recruiting NCT04203134
23 Study of the Efficacy of Melatonin in the Burning Mouth Syndrome Recruiting NCT03788733 Melatonin 3 mg;Placebo Oral
24 Modeling Kappa Opioid Analgesic Mechanisms in Chronic Orofacial Pain Disorders Terminated NCT00716807 nalbuphine plus naloxone;nalbuphine plus placebo;nalbuphine plus naloxone;nalbuphine plus placebo

Search NIH Clinical Center for Burning Mouth Syndrome

Cochrane evidence based reviews: burning mouth syndrome

Genetic Tests for Burning Mouth Syndrome

Anatomical Context for Burning Mouth Syndrome

MalaCards organs/tissues related to Burning Mouth Syndrome:

40
Tongue, Testes, Salivary Gland, Brain, Skin, Cortex, Thyroid

Publications for Burning Mouth Syndrome

Articles related to Burning Mouth Syndrome:

(show top 50) (show all 918)
# Title Authors PMID Year
1
General health status of a sample of patients with burning mouth syndrome: A case-control study. 61
32153093 2020
2
Altered pain modulation to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome. 61
32531814 2020
3
Psychophysical characterisation of burning mouth syndrome-A systematic review and meta-analysis. 61
32500929 2020
4
Mandibular Nerve Block for Long-Term Pain Relief in a Case of Refractory Burning Mouth Syndrome. 61
32052263 2020
5
Symptom severity in burning mouth syndrome associates with psychological factors. 61
32196724 2020
6
Limited Utility for Benzodiazepines in Chronic Pain Management: A Narrative Review. 61
32378069 2020
7
The effect of multisensory illusions on pain and perceived burning sensations in patients with Burning Mouth Syndrome: A proof-of-concept study. 61
32531809 2020
8
Headache in the Older Population: Causes, Diagnoses, and Treatments. 61
32472308 2020
9
Effects of photobiomodulation with low-level laser therapy in burning mouth syndrome: A randomized clinical trial. 61
32460396 2020
10
Low-Dose Aripiprazole Augmentation in the Treatment of Burning Mouth Syndrome: A Case Report. 61
32217865 2020
11
Pain reduction in burning mouth syndrome (BMS) may be associated with selective improvement of taste: a retrospective study. 61
32147381 2020
12
The Impact of Orofacial Pain Conditions on Oral Health Related Quality of Life: A Systematic Review. 61
32415993 2020
13
Letter to the Editor: "General health status of a sample of patients with Burning Mouth Syndrome: a case-controlstudy". 61
32285605 2020
14
Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions in Burning Mouth Syndrome: A Retrospective Analysis. 61
32255581 2020
15
Burning Mouth Syndrome-Opening the Door to a Psychosomatic Approach in the Era of Patient-Centered Medicine. 61
32352502 2020
16
Evaluation of IL-6 levels and +3954 polymorphism of IL-1β in burning mouth syndrome: A systematic review and meta-analysis. 61
32274841 2020
17
Characterization of burning mouth syndrome profiles based on response to a local anaesthetic lozenge. 61
31880064 2020
18
122 Burning Mouth Syndrome as a Focus of Delusion. 61
32331081 2020
19
Association Between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease. 61
32352482 2020
20
Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome. 61
31679908 2020
21
Neuropathic Pain and Burning Mouth Syndrome: An Overview and Current Update. 61
32111276 2020
22
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in burning mouth syndrome patients with iron deficiency. 61
32256999 2020
23
Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in burning mouth syndrome patients with vitamin B12 deficiency. 61
32256998 2020
24
A perspective from experimental studies of burning mouth syndrome. 61
32161235 2020
25
Salivary Biomarkers and Their Correlation with Pain and Stress in Patients with Burning Mouth Syndrome. 61
32231113 2020
26
Burning mouth syndrome associated with tumor necrosis factor (TNF)-α inhibitor. 61
31646631 2020
27
Salivary Cortisol Levels and Burning Symptoms in Patients with Burning Mouth Syndrome before and after Low Level Laser Therapy: a Double Blind Controlled Randomized Clinical Trial. 61
32523156 2020
28
A Case Report of Burning Mouth Syndrome Treated with Individualised Homeopathy. 61
31505694 2020
29
[Current advances in research of burning mouth syndrome: biological nerve and social psychology patterns]. 61
32074676 2020
30
Recent advances in the understanding of the aetiology and therapeutic strategies in burning mouth syndrome: Focus on the actions of cannabinoids. 61
32091630 2020
31
Burning mouth syndrome: a diagnostic challenge. 61
31678041 2020
32
Burning Mouth Syndrome and Contact Dermatitis. 61
32091459 2020
33
Prevalence of and related risk factors in oral mucosa diseases among residents in the Baoshan District of Shanghai, China. 61
32140308 2020
34
Vortioxetine in the Treatment of Mood Disorders Associated with Burning Mouth Syndrome: Results of an Open-Label, Flexible-Dose Pilot Study. 61
31343684 2020
35
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
36
Efficacy of Low-Level Laser Therapy for the Therapeutic Management of Neuropathic Orofacial Pain: A Systematic Review. 61
31339967 2020
37
Pharmacotherapy in relieving the symptoms of burning mouth syndrome: A 1-year follow-up study. 61
31705718 2020
38
Comparison of clinical characteristics between burning mouth syndrome patients with bilateral and unilateral symptoms. 61
31235389 2020
39
Time-dependent responses in brain activity to ongoing hot stimulation in burning mouth syndrome. 61
32224570 2020
40
A case of burning mouth syndrome leading to suicide 10 days after self-cutting of tongue. 61
30957297 2020
41
Medical comorbidities of patients with burning mouth syndrome. 61
31466124 2020
42
Assessment of oral health-related quality of life, measured by OHIP-14 and GOHAI, and psychological profiling in burning mouth syndrome: A case-control clinical study. 61
31332814 2020
43
The Complaints, Type, and Severity of Stressful Events in Patients with Burning Mouth Syndrome Referring to Zahedan School of Dentistry, Iran. 61
32308496 2020
44
The precedence and viability of yoga in the lives of D3-dental students, dental practitioners, and dental patients. 61
31879617 2019
45
Eugenol allergy mimicking recurrent aphthous stomatitis and burning mouth syndrome. 61
31373017 2019
46
Topical application in burning mouth syndrome. 61
31890121 2019
47
Real-world Discontinuation of Antidepressant Treatment in Patients with Burning Mouth Syndrome: A Chart Review. 61
31841160 2019
48
Prevalence of Chronic Orofacial Pain in Elderly Patients Referred to Shiraz Dental School From 2005 to 2017. 61
32280612 2019
49
Photobiomodulation in Oral Medicine. 61
31873066 2019
50
Differential Diagnosis of Chronic Neuropathic Orofacial Pain: Role of Clinical Neurophysiology. 61
31688325 2019

Variations for Burning Mouth Syndrome

Expression for Burning Mouth Syndrome

Search GEO for disease gene expression data for Burning Mouth Syndrome.

Pathways for Burning Mouth Syndrome

Pathways related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 TNF NGF IL6 IL2 IL1B CXCL8
2
Show member pathways
12.82 TNF IL6 IL2 IL1B CXCL8
3
Show member pathways
12.78 TNF IL6 IL2 IL1B CXCL8
4
Show member pathways
12.66 TNF NGF IL6 IL2 IL1B
5
Show member pathways
12.55 TNF IL6 IL2 IL1B
6
Show member pathways
12.55 TNF IL6 IL2 IL1B
7 12.54 SCN9A NGF CNR1 CALCA
8
Show member pathways
12.54 TNF IL6 IL2 IL1B
9
Show member pathways
12.3 TNF IL6 IL1B CXCL8
10
Show member pathways
12.3 TNF IL6 IL2 CXCL8
11
Show member pathways
12.3 TNF IL6 IL2 IL1B
12
Show member pathways
12.28 TNF IL6 IL1B CXCL8
13 12.27 TNF IL6 IL1B CXCL8
14 12.24 TNF IL6 IL1B CXCL8
15 12.21 TNF IL6 IL1B CXCL8
16
Show member pathways
12.17 TNF IL6 IL2 IL1B
17
Show member pathways
12.16 TNF NGF IL6 IL2 IL1B CXCL8
18
Show member pathways
12.15 TNF IL6 IL1B CXCL8
19 11.95 TNF IL6 IL2
20 11.95 TNF IL6 IL1B CXCL8
21 11.93 TNF IL6 IL1B
22 11.9 IL6 IL1B CXCL8
23
Show member pathways
11.9 TNF IL6 IL2 IL1B
24 11.89 TNF IL1B CXCL8
25 11.88 TNF IL6 IL1B CXCL8
26 11.86 TNF IL6 IL1B
27 11.86 TNF IL6 IL1B CXCL8
28 11.85 TNF IL6 IL2 IL1B CXCL8
29 11.82 TNF IL6 IL1B CXCL8
30 11.8 TNF IL6 IL2 IL1B CXCL8
31 11.78 IL6 IL2 CXCL8
32 11.76 TNF IL2 IL1B
33
Show member pathways
11.74 TNF IL2 CXCL8
34 11.71 TNF IL6 IL1B CXCL8
35 11.68 TNF IL6 IL2 IL1B
36 11.55 TNF IL6 IL1B CXCL8
37 11.53 TNF IL6 IL2
38 11.5 TNF IL2 IL1B
39 11.46 TNF IL6 IL1B CXCL8
40
Show member pathways
11.43 TNF SLC6A4 IL1B
41 11.42 TNF IL6 IL1B CXCL8
42 11.38 TNF TAC1 SLC6A4 NGF IL6 IL1B
43 11.36 TNF IL6 IL1B
44 11.36 TNF IL6 IL1B CALCA
45
Show member pathways
11.35 TNF IL6 IL2 IL1B CXCL8
46 11.33 TNF IL6 IL1B
47 11.29 TNF IL6 IL1B
48 11.27 TNF IL6 IL1B
49 11.15 TNF IL6 IL1B CXCL8 CALCA
50 11.02 TNF IL6 IL2 IL1B

GO Terms for Burning Mouth Syndrome

Cellular components related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.88 TRPV1 TAC1 P2RX3 IL6 IL2 CALCA
2 extracellular space GO:0005615 9.81 TNF TAC1 NGF IL6 IL2 IL1B
3 membrane raft GO:0045121 9.67 TNF SLC6A4 P2RX3 CNR1
4 neuron projection GO:0043005 9.65 TRPV1 SLC6A4 SCN9A P2RX3 CALCA
5 extracellular region GO:0005576 9.65 TNF TAC1 NGF MUC7 IL6 IL2
6 integral component of presynaptic membrane GO:0099056 9.5 SLC6A4 P2RX3 CNR1
7 axon GO:0030424 9.1 TAC1 SCN9A P2RX3 NGF CNR1 CALCA

Biological processes related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.02 TNF IL6 IL2 IL1B CXCL8
2 positive regulation of gene expression GO:0010628 10.01 TNF SLC6A4 NGF IL6 IL1B
3 MAPK cascade GO:0000165 9.95 TNF IL2 IL1B ARTN
4 cell-cell signaling GO:0007267 9.94 TAC1 IL2 IL1B CALCA
5 positive regulation of apoptotic process GO:0043065 9.93 TRPV1 TNF NGF IL6 CNR1
6 cellular response to lipopolysaccharide GO:0071222 9.89 TNF IL6 IL1B CXCL8
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.87 TNF IL6 IL1B
8 positive regulation of cytosolic calcium ion concentration GO:0007204 9.85 TRPV1 TAC1 IL2 CALCA
9 positive regulation of inflammatory response GO:0050729 9.84 TNF IL2 IL1B
10 response to organic substance GO:0010033 9.84 TNF SLC6A4 P2RX3
11 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.83 TNF NGF IL6
12 memory GO:0007613 9.83 SLC6A4 NGF CNR1
13 cytokine-mediated signaling pathway GO:0019221 9.83 TNF IL6 IL2 IL1B CXCL8
14 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.81 TNF IL6 IL2
15 regulation of insulin secretion GO:0050796 9.8 TNF IL1B CNR1
16 positive regulation of T cell proliferation GO:0042102 9.79 IL6 IL2 IL1B
17 positive regulation of interleukin-6 production GO:0032755 9.77 TNF IL6 IL1B
18 positive regulation of interferon-gamma production GO:0032729 9.76 TNF IL2 IL1B
19 response to heat GO:0009408 9.74 TRPV1 P2RX3 CALCA
20 positive regulation of nitric oxide biosynthetic process GO:0045429 9.73 TRPV1 TNF IL1B
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.7 TNF IL1B
22 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.7 TRPV1 CALCA
23 negative regulation of bone resorption GO:0045779 9.7 IL6 CALCA
24 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.7 TNF IL1B
25 cellular response to nerve growth factor stimulus GO:1990090 9.7 TRPV1 TAC1 CALCA
26 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.69 TNF IL1B
27 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.69 TNF IL6
28 response to carbohydrate GO:0009743 9.68 P2RX3 IL1B
29 induction of positive chemotaxis GO:0050930 9.68 CXCL8 ARTN
30 positive regulation of acute inflammatory response GO:0002675 9.68 TAC1 IL6
31 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF IL1B
32 positive regulation of immunoglobulin secretion GO:0051024 9.67 IL6 IL2
33 negative regulation of heart rate GO:0010459 9.67 TRPV1 TAC1
34 negative regulation of lipid storage GO:0010888 9.65 TNF IL6
35 positive regulation of interleukin-8 production GO:0032757 9.65 TNF IL1B CALCA
36 regulation of establishment of endothelial barrier GO:1903140 9.64 TNF IL1B
37 negative regulation of neurogenesis GO:0050768 9.63 TNF IL6 IL1B
38 urinary bladder smooth muscle contraction GO:0014832 9.61 TRPV1 P2RX3
39 sequestering of triglyceride GO:0030730 9.58 TNF IL1B
40 response to pain GO:0048265 9.58 TRPV1 TAC1 CALCA
41 positive regulation of glial cell proliferation GO:0060252 9.54 TNF IL6 IL1B
42 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 TNF IL1B
43 behavioral response to pain GO:0048266 9.5 TRPV1 SCN9A P2RX3
44 fever generation GO:0001660 9.49 TRPV1 IL1B
45 sensory perception of pain GO:0019233 9.46 TRPV1 TAC1 SCN9A CNR1
46 positive regulation of neuroinflammatory response GO:0150078 9.43 TNF IL6 IL1B
47 inflammatory response GO:0006954 9.23 TRPV1 TNF TAC1 SCN9A IL6 IL1B
48 positive regulation of fever generation GO:0031622 9.13 TNF IL1B CNR1

Molecular functions related to Burning Mouth Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 NGF IL6 IL2 ARTN
2 cytokine activity GO:0005125 9.02 TNF IL6 IL2 IL1B CXCL8

Sources for Burning Mouth Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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