MCID: C1Q005
MIFTS: 23

C1q Nephropathy

Categories: Rare diseases, Nephrological diseases

Aliases & Classifications for C1q Nephropathy

MalaCards integrated aliases for C1q Nephropathy:

Name: C1q Nephropathy 53 73

Classifications:



External Ids:

UMLS 73 C0403434

Summaries for C1q Nephropathy

NIH Rare Diseases : 53 C1q nephropathy is a kidney disease in which a large amount of protein is lost in the urine. It is one of the many diseases that can cause the nephrotic syndrome. C1q is a normal protein in the immune system, and can be found floating in the circulation of most healthy people. In C1q nephropathy, however, this protein can also be found deposited throughout the kidneys. It has been thought to be a subgroup of primary focal segmental glomerulosclerosis or to be a combination of several disease groups rather than a single disease. As a disease, it is very similar to minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Criteria diagnosis includes C1q deposits on the kidney and no evidence of systemic lupus erythematosus. Both children and adult patients may have no symptoms, except for the presence of blood or protein in the urine, or  present with swelling of the feet and legs, high blood pressure and kidney insufficiency. The treatment of C1q nephropathy is the same as for MCD or FSGS and includes corticosteroids and other immunosuppressive agents. Further research is needed to establish C1q nephropathy as a recognized distinct clinical entity.

MalaCards based summary : C1q Nephropathy is related to glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with C1q Nephropathy is CD40LG (CD40 Ligand), and among its related pathways/superpathways are NF-kappaB Signaling and Primary immunodeficiency. Affiliated tissues include kidney.

Related Diseases for C1q Nephropathy

Diseases in the C1q Nephropathy family:

Bk-Virus Nephropathy

Diseases related to C1q Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 29.4 CD40LG CD79A
2 mesangial proliferative glomerulonephritis 11.1
3 nephrotic syndrome 10.0
4 selective igg deficiency disease 10.0 CD40LG CD79A
5 meningovascular neurosyphilis 10.0 CD40LG CD79A
6 alpha chain disease 10.0 CD40LG CD79A
7 brill-zinsser disease 10.0 CD40LG CD79A
8 exudative glomerulonephritis 10.0 CD40LG CD79A
9 cork-handlers' disease 10.0 CD40LG CD79A
10 salpingo-oophoritis 10.0 CD40LG CD79A
11 early yaws 10.0 CD40LG CD79A
12 ventilation pneumonitis 10.0 CD40LG CD79A
13 chronic interstitial cystitis 10.0 CD40LG CD79A
14 axillary adenitis 10.0 CD40LG CD79A
15 cryofibrinogenemia 10.0 CD40LG CD79A
16 trichostrongyloidiasis 10.0 CD40LG CD79A
17 subacute bacterial endocarditis 10.0 CD40LG CD79A
18 heterophyiasis 10.0 CD40LG CD79A
19 immunoglobulin g deficiency 10.0 CD40LG CD79A
20 orbital granuloma 10.0 CD40LG CD79A
21 transient hypogammaglobulinemia of infancy 10.0 CD40LG CD79A
22 hyperglobulinemic purpura 10.0 CD40LG CD79A
23 gastroduodenitis 10.0 CD40LG CD79A
24 bacterial conjunctivitis 10.0 CD40LG CD79A
25 heavy chain disease 10.0 CD40LG CD79A
26 ophthalmia neonatorum 10.0 CD40LG CD79A
27 immunoglobulin a deficiency 1 10.0 CD40LG CD79A
28 parotid disease 10.0 CD40LG CD79A
29 cerebral arteritis 10.0 CD40LG CD79A
30 selective immunoglobulin deficiency disease 10.0 CD40LG CD79A
31 geniculate herpes zoster 10.0 CD40LG CD79A
32 erythema elevatum diutinum 10.0 CD40LG CD79A
33 sporotrichosis 10.0 CD40LG CD79A
34 fallopian tube disease 10.0 CD40LG CD79A
35 hyperimmunoglobulin syndrome 10.0 CD40LG CD79A
36 congenital syphilis 10.0 CD40LG CD79A
37 polyclonal hypergammaglobulinemia 10.0 CD40LG CD79A
38 monoclonal paraproteinemia 10.0 CD40LG CD79A
39 salpingitis 10.0 CD40LG CD79A
40 ocular toxoplasmosis 10.0 CD40LG CD79A
41 dysgammaglobulinemia 10.0 CD40LG CD79A
42 congenital hypogammaglobulinemia 10.0 CD40LG CD79A
43 acute maxillary sinusitis 10.0 CD40LG CD79A
44 chronic polyneuropathy 10.0 CD40LG CD79A
45 spinocerebellar ataxia, autosomal recessive 10 10.0 CD40LG CD79A
46 parasitic ichthyosporea infectious disease 10.0 CD40LG CD79A
47 cd40 ligand deficiency 10.0 CD40LG CD79A
48 rhinosporidiosis 10.0 CD40LG CD79A
49 secondary syphilis 10.0 CD40LG CD79A
50 yellow nail syndrome 10.0 CD40LG CD79A

Graphical network of the top 20 diseases related to C1q Nephropathy:



Diseases related to C1q Nephropathy

Symptoms & Phenotypes for C1q Nephropathy

Drugs & Therapeutics for C1q Nephropathy

Search Clinical Trials , NIH Clinical Center for C1q Nephropathy

Genetic Tests for C1q Nephropathy

Anatomical Context for C1q Nephropathy

MalaCards organs/tissues related to C1q Nephropathy:

41
Kidney

Publications for C1q Nephropathy

Articles related to C1q Nephropathy:

(show all 32)
# Title Authors Year
1
Successful treatment of C1q nephropathy with CD19 targeted Rituximab therapy. ( 28205352 )
2017
2
[Advances in clinical research on C1q nephropathy]. ( 27817791 )
2016
3
Successful Treatment of C1q Nephropathy by Low-Density Lipoprotein Apheresis. ( 27071380 )
2016
4
C1q nephropathy in India: a single-center study. ( 25758901 )
2015
5
AJKD Atlas of Renal Pathology: C1q Nephropathy. ( 26300202 )
2015
6
A clinicopathological study of C1q nephropathy at King Abdulaziz University. ( 26174454 )
2015
7
C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases. ( 26586072 )
2015
8
C1q Nephropathy: The Unique Underrecognized Pathological Entity. ( 26640759 )
2015
9
C1q nephropathy in the setting of granulomatosis with polyangiitis treated with tacrolimus. ( 25878789 )
2014
10
C1q nephropathy in children: clinical characteristics and outcome. ( 24326785 )
2014
11
C1q nephropathy in an old woman with acute renal failure: a case report and literature review. ( 24845397 )
2014
12
C1q nephropathy- unity in diversity. ( 25340146 )
2013
13
Diverse clinical and histology presentation in c1q nephropathy. ( 24282787 )
2013
14
Concurrent diabetic nephropathy and C1q nephropathy in a young male patient: The first report in literature. ( 24475450 )
2013
15
C1q nephropathy with acute hemolytic uremic syndrome. ( 22569444 )
2012
16
Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy? ( 22595394 )
2012
17
C1q nephropathy presenting as nephritic-nephrotic syndrome. ( 22237242 )
2012
18
C1q nephropathy and malignancy. ( 22466284 )
2012
19
Non-nephronal hematuria misdiagnosed as C1q nephropathy: Look before you leap. ( 23087557 )
2012
20
C1q nephropathy presenting as nephritic-nephrotic syndrome. ( 21566322 )
2011
21
C1q nephropathy presenting as acute renal failure. ( 21912049 )
2011
22
Resolution of clinical and pathologic features of C1q nephropathy after rituximab therapy. ( 21107633 )
2011
23
C1q nephropathy in a patient with Gitelman syndrome. ( 25984202 )
2011
24
C1q nephropathy presenting as acute renal failure. ( 21422635 )
2011
25
C1q nephropathy associated with deletion of long arm of chromosome 7. ( 20642652 )
2010
26
Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. ( 20116156 )
2010
27
Proteinuria in a boy with infectious mononucleosis, C1q nephropathy, and Dent's disease. ( 17982249 )
2007
28
C1q nephropathy in a 2-year-old boy presenting with steroid resistant nephrotic syndrome. ( 21318945 )
2007
29
C1q nephropathy in association with Gitelman syndrome: a case report. ( 16955279 )
2006
30
C1q nephropathy: a variant of focal segmental glomerulosclerosis. ( 12969141 )
2003
31
C1q nephropathy presenting as rapidly progressive crescentic glomerulonephritis. ( 10975310 )
2000
32
Pan-nephritis (glomerulonephritis, arteriolitis, and tubulointerstitial nephritis) associated with predominant mesangial C1q deposition and hypocomplementemia: a variant type of C1q nephropathy? ( 8678071 )
1996

Variations for C1q Nephropathy

Expression for C1q Nephropathy

Search GEO for disease gene expression data for C1q Nephropathy.

Pathways for C1q Nephropathy

Pathways related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.47 CD40LG CD79A
2 10.19 CD40LG CD79A

GO Terms for C1q Nephropathy

Cellular components related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG CD79A

Biological processes related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for C1q Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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