MCID: C1Q005
MIFTS: 21

C1q Nephropathy

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for C1q Nephropathy

MalaCards integrated aliases for C1q Nephropathy:

Name: C1q Nephropathy 20 70

Classifications:



External Ids:

UMLS 70 C0403434

Summaries for C1q Nephropathy

GARD : 20 C1q nephropathy is a kidney disease in which a large amount of protein is lost in the urine. It is one of the many diseases that can cause the nephrotic syndrome. C1q is a normal protein in the immune system, and can be found floating in the circulation of most healthy people. In C1q nephropathy, however, this protein can also be found deposited throughout the kidneys. It has been thought to be a subgroup of primary focal segmental glomerulosclerosis or to be a combination of several disease groups rather than a single disease. As a disease, it is very similar to minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Criteria diagnosis includes C1q deposits on the kidney and no evidence of systemic lupus erythematosus. Both children and adult patients may have no symptoms, except for the presence of blood or protein in the urine, or present with swelling of the feet and legs, high blood pressure and kidney insufficiency. The treatment of C1q nephropathy is the same as for MCD or FSGS and includes corticosteroids and other immunosuppressive agents. Further research is needed to establish C1q nephropathy as a recognized distinct clinical entity.

MalaCards based summary : C1q Nephropathy is related to glomerulonephritis and iga glomerulonephritis. An important gene associated with C1q Nephropathy is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Immune response NFAT in immune response and NF-kappaB Signaling. Affiliated tissues include kidney, bone marrow and pancreas.

Related Diseases for C1q Nephropathy

Diseases in the C1q Nephropathy family:

Bk-Virus Nephropathy

Diseases related to C1q Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 30.5 CD79A CD40LG
2 iga glomerulonephritis 29.5 CD79A CD40LG
3 autoimmune disease 29.3 CD79A CD40LG
4 mesangial proliferative glomerulonephritis 11.2
5 nephrotic syndrome 10.6
6 proteinuria, chronic benign 10.6
7 focal segmental glomerulosclerosis 10.5
8 proliferative glomerulonephritis 10.5
9 end stage renal disease 10.3
10 glomerular disease 10.3
11 membranoproliferative glomerulonephritis 10.3
12 kidney disease 10.2
13 acute kidney failure 10.1
14 gitelman syndrome 10.0
15 membranous nephropathy 10.0
16 crescentic glomerulonephritis 10.0
17 bartter disease 10.0
18 immune-complex glomerulonephritis 10.0
19 pfeiffer syndrome 9.9
20 retinoblastoma 9.9
21 dermatitis, atopic 9.9
22 granulomatosis with polyangiitis 9.9
23 lipomyelomeningocele 9.9
24 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 9.9
25 microvascular complications of diabetes 3 9.9
26 microvascular complications of diabetes 4 9.9
27 microvascular complications of diabetes 6 9.9
28 microvascular complications of diabetes 7 9.9
29 glucocorticoid resistance, generalized 9.9
30 disease by infectious agent 9.9
31 paroxysmal nocturnal hemoglobinuria 9.9
32 interstitial nephritis 9.9
33 nephrosclerosis 9.9
34 hemolytic-uremic syndrome 9.9
35 urethritis 9.9
36 dermatitis 9.9
37 gastric adenocarcinoma 9.9
38 hemoglobinuria 9.9
39 hemolytic anemia 9.9
40 chronic kidney disease 9.9
41 collagen disease 9.9
42 neurofibromatosis 9.9
43 lupus erythematosus 9.9
44 hemorrhagic fever-renal syndrome 9.9 CD79A CD40LG
45 cryofibrinogenemia 9.9 CD79A CD40LG
46 immunoglobulin g deficiency 9.9 CD79A CD40LG
47 ocular toxoplasmosis 9.9 CD79A CD40LG
48 toxoplasmosis 9.9 CD79A CD40LG
49 respiratory papillomatosis, juvenile recurrent, congenital 9.9 CD79A CD40LG
50 congenital syphilis 9.9 CD79A CD40LG

Graphical network of the top 20 diseases related to C1q Nephropathy:



Diseases related to C1q Nephropathy

Symptoms & Phenotypes for C1q Nephropathy

Drugs & Therapeutics for C1q Nephropathy

Search Clinical Trials , NIH Clinical Center for C1q Nephropathy

Genetic Tests for C1q Nephropathy

Anatomical Context for C1q Nephropathy

MalaCards organs/tissues related to C1q Nephropathy:

40
Kidney, Bone Marrow, Pancreas

Publications for C1q Nephropathy

Articles related to C1q Nephropathy:

(show top 50) (show all 96)
# Title Authors PMID Year
1
[Four cases of nephrotic syndrome with TRPC6 gene variations and literature review]. 61
33657698 2021
2
Clinicopathological Pattern of Non-lupus Full House Nephropathy. 61
33707816 2020
3
[C1q nephropathy. Report of one case]. 61
33399765 2020
4
C1q nephropathy in a patient complicated with nephrotic syndrome and refractory to steroid therapy. 61
31288973 2020
5
Case Report: Complete Remission of C1q Nephropathy Treated With a Single Low-Dose Rituximab, a Reality or Coincidence? 61
33634050 2020
6
C1q nephropathy developing in a case of gastric carcinoma. 61
31929296 2019
7
Nephrotic syndrome: immunological mechanisms. 61
31630708 2019
8
C1Q Nephropathy: A Multifaceted Disease With Infrequent Diagnosis. 61
31535496 2019
9
C1q Nephropathy in a Patient of Neurofibromatosis Type 1: A Rare Case Report. 61
30983754 2019
10
C1q nephropathy in adults is a form of focal segmental glomerulosclerosis in terms of clinical characteristics. 61
31002691 2019
11
A minimum changes disease compatible with C1q nephropathy in a paediatric patient. Evolution and treatment of a difficult pathology. 61
30075963 2019
12
Predominant but silent C1q deposits in mesangium on transplanted kidneys - long-term observational study. 61
29625558 2018
13
C1q nephropathy among children with nephrotic syndrome: Ten-year experience from a pediatric nephrology unit. 61
30102475 2018
14
[Renal diseases related to MYH9 disorders]. 61
28682562 2017
15
Successful treatment of C1q nephropathy with CD19 targeted Rituximab therapy. 61
28205352 2017
16
[Advances in clinical research on C1q nephropathy]. 61
27817791 2016
17
Successful Treatment of C1q Nephropathy by Low-Density Lipoprotein Apheresis. 61
27071380 2016
18
C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases. 61
26586072 2015
19
[C1Q NEPHROPATHY: CASE REPORTS AND LITERATURE REVIEW]. 61
26749950 2015
20
AJKD Atlas of Renal Pathology: C1q Nephropathy. 61
26300202 2015
21
A clinicopathological study of C1q nephropathy at King Abdulaziz University. 61
26174454 2015
22
Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria. 61
26022031 2015
23
Resolution of C1q deposition but not of the clinical nephrotic syndrome after immunomodulating therapy in focal sclerosis. 61
25964890 2015
24
C1q nephropathy in India: a single-center study. 61
25758901 2015
25
Long-term results of children diagnosed with idiopathic nephrotic syndrome; single center experience. 61
26078695 2015
26
C1q Nephropathy: The Unique Underrecognized Pathological Entity. 61
26640759 2015
27
Multiple myeloma after kidney transplantation. 61
25377159 2015
28
C1q nephropathy in the setting of granulomatosis with polyangiitis treated with tacrolimus. 61
25878789 2014
29
C1q nephropathy in an old woman with acute renal failure: a case report and literature review. 61
24845397 2014
30
C1q nephropathy in children: clinical characteristics and outcome. 61
24326785 2014
31
Do C1q or IgM nephropathies predict disease severity in children with minimal change nephrotic syndrome? 61
23852271 2014
32
Pathological patterns of mesangioproliferative glomerulonephritis seen at a tertiary care center. 61
28197459 2014
33
De novo glomerulitis associated with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: A single-center experience. 61
26877927 2013
34
Concurrent diabetic nephropathy and C1q nephropathy in a young male patient: The first report in literature. 61
24475450 2013
35
Diverse clinical and histology presentation in c1q nephropathy. 61
24282787 2013
36
C1q nephropathy- unity in diversity. 61
25340146 2013
37
Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy? 61
22595394 2012
38
Non-nephronal hematuria misdiagnosed as C1q nephropathy: Look before you leap. 61
23087557 2012
39
C1q nephropathy with acute hemolytic uremic syndrome. 61
22569444 2012
40
C1q nephropathy and malignancy. 61
22466284 2012
41
C1q nephropathy presenting as nephritic-nephrotic syndrome. 61
22237242 2012
42
C1q nephropathy in a patient with Gitelman syndrome. 61
25984202 2011
43
C1q nephropathy presenting as acute renal failure. 61
21912049 2011
44
Crescentic glomerulonephritis: a clinical and histomorphological analysis of 46 cases. 61
21934209 2011
45
Partial remission of resistant nephrotic syndrome after oral galactose therapy. 61
21624074 2011
46
C1q nephropathy presenting as nephritic-nephrotic syndrome. 61
21566322 2011
47
C1q nephropathy presenting as acute renal failure. 61
21422635 2011
48
Resolution of clinical and pathologic features of C1q nephropathy after rituximab therapy. 61
21107633 2011
49
C1q deposition in the renal allograft: a report of 24 cases. 61
20473274 2010
50
C1q nephropathy in the pediatric population: pathology and pathogenesis. 61
20180137 2010

Variations for C1q Nephropathy

Expression for C1q Nephropathy

Search GEO for disease gene expression data for C1q Nephropathy.

Pathways for C1q Nephropathy

Pathways related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CD79A CD40LG
2 11.47 CD79A CD40LG
3 10.2 CD79A CD40LG

GO Terms for C1q Nephropathy

Cellular components related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD79A CD40LG

Biological processes related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD79A CD40LG
2 B cell proliferation GO:0042100 8.62 CD79A CD40LG

Sources for C1q Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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