MCID: C1Q005
MIFTS: 24

C1q Nephropathy

Categories: Nephrological diseases, Rare diseases

Aliases & Classifications for C1q Nephropathy

MalaCards integrated aliases for C1q Nephropathy:

Name: C1q Nephropathy 53 73

Classifications:



External Ids:

UMLS 73 C0403434

Summaries for C1q Nephropathy

NIH Rare Diseases : 53 C1q nephropathy is a kidney disease in which a large amount of protein is lost in the urine. It is one of the many diseases that can cause the nephrotic syndrome. C1q is a normal protein in the immune system, and can be found floating in the circulation of most healthy people. In C1q nephropathy, however, this protein can also be found deposited throughout the kidneys. It has been thought to be a subgroup of primary focal segmental glomerulosclerosis or to be a combination of several disease groups rather than a single disease. As a disease, it is very similar to minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). Criteria diagnosis includes C1q deposits on the kidney and no evidence of systemic lupus erythematosus. Both children and adult patients may have no symptoms, except for the presence of blood or protein in the urine, or  present with swelling of the feet and legs, high blood pressure and kidney insufficiency. The treatment of C1q nephropathy is the same as for MCD or FSGS and includes corticosteroids and other immunosuppressive agents. Further research is needed to establish C1q nephropathy as a recognized distinct clinical entity.

MalaCards based summary : C1q Nephropathy is related to glomerulonephritis and mesangial proliferative glomerulonephritis. An important gene associated with C1q Nephropathy is CD40LG (CD40 Ligand), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Immune response NFAT in immune response. Affiliated tissues include kidney, pancreas and ovary.

Related Diseases for C1q Nephropathy

Diseases in the C1q Nephropathy family:

Bk-Virus Nephropathy

Diseases related to C1q Nephropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 29.9 CD40LG CD79A
2 mesangial proliferative glomerulonephritis 11.3
3 nephrotic syndrome 10.4
4 kidney disease 10.1
5 gitelman syndrome 10.1
6 focal segmental glomerulosclerosis 1 10.1
7 focal segmental glomerulosclerosis 10.1
8 crescentic glomerulonephritis 10.1
9 immunoglobulin g deficiency 9.9 CD40LG CD79A
10 cryofibrinogenemia 9.9 CD40LG CD79A
11 heparin-induced thrombocytopenia 9.9 CD40LG CD79A
12 immunoglobulin a deficiency 1 9.9 CD40LG CD79A
13 sporotrichosis 9.9 CD40LG CD79A
14 congenital syphilis 9.9 CD40LG CD79A
15 syphilis 9.9 CD40LG CD79A
16 secondary syphilis 9.9 CD40LG CD79A
17 immunodeficiency-centromeric instability-facial anomalies syndrome 1 9.9 CD40LG CD79A
18 ocular toxoplasmosis 9.9 CD40LG CD79A
19 toxoplasmosis 9.9 CD40LG CD79A
20 persistent generalized lymphadenopathy 9.9 CD40LG CD79A
21 immunodeficiency with hyper-igm, type 1 9.9 CD40LG CD79A
22 dermatitis, atopic 9.9
23 granulomatosis with polyangiitis 9.9
24 hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy 9.9
25 microvascular complications of diabetes 3 9.9
26 microvascular complications of diabetes 4 9.9
27 microvascular complications of diabetes 6 9.9
28 microvascular complications of diabetes 7 9.9
29 membranous nephropathy 9.9
30 lipoid nephrosis 9.9
31 hemolytic-uremic syndrome 9.9
32 dermatitis 9.9
33 congenital toxoplasmosis 9.9 CD40LG CD79A
34 immunoglobulin alpha deficiency 9.9 CD40LG CD79A
35 cryptosporidiosis 9.9 CD40LG CD79A
36 pustulosis palmaris et plantaris 9.9 CD40LG CD79A
37 dysgerminoma of ovary 9.9 CD40LG CD79A
38 marginal zone b-cell lymphoma 9.9 CD40LG CD79A
39 meningoencephalitis 9.9 CD40LG CD79A
40 cryoglobulinemia 9.9 CD40LG CD79A
41 agammaglobulinemia, x-linked 9.9 CD40LG CD79A
42 immune deficiency disease 9.8 CD40LG CD79A
43 iga glomerulonephritis 9.8 CD40LG CD79A
44 tetanus 9.8 CD40LG CD79A
45 common variable immunodeficiency 9.8 CD40LG CD79A
46 autoimmune disease 9.7 CD40LG CD79A

Graphical network of the top 20 diseases related to C1q Nephropathy:



Diseases related to C1q Nephropathy

Symptoms & Phenotypes for C1q Nephropathy

Drugs & Therapeutics for C1q Nephropathy

Search Clinical Trials , NIH Clinical Center for C1q Nephropathy

Genetic Tests for C1q Nephropathy

Anatomical Context for C1q Nephropathy

MalaCards organs/tissues related to C1q Nephropathy:

41
Kidney, Pancreas, Ovary, B Cells

Publications for C1q Nephropathy

Articles related to C1q Nephropathy:

(show top 50) (show all 60)
# Title Authors Year
1
A minimum changes disease compatible with C1q nephropathy in a paediatric patient. Evolution and treatment of a difficult pathology. ( 30075963 )
2018
2
C1q nephropathy among children with nephrotic syndrome: Ten-year experience from a pediatric nephrology unit. ( 30102475 )
2018
3
Successful treatment of C1q nephropathy with CD19 targeted Rituximab therapy. ( 28205352 )
2017
4
[Advances in clinical research on C1q nephropathy]. ( 27817791 )
2016
5
Successful Treatment of C1q Nephropathy by Low-Density Lipoprotein Apheresis. ( 27071380 )
2016
6
C1q nephropathy in India: a single-center study. ( 25758901 )
2015
7
AJKD Atlas of Renal Pathology: C1q Nephropathy. ( 26300202 )
2015
8
A clinicopathological study of C1q nephropathy at King Abdulaziz University. ( 26174454 )
2015
9
C1q nephropathy and isolated CD59 deficiency manifesting as necrotizing crescentic glomerulonephritis: A rare association of two diseases. ( 26586072 )
2015
10
C1q Nephropathy: The Unique Underrecognized Pathological Entity. ( 26640759 )
2015
11
C1q nephropathy in the setting of granulomatosis with polyangiitis treated with tacrolimus. ( 25878789 )
2014
12
C1q nephropathy in children: clinical characteristics and outcome. ( 24326785 )
2014
13
C1q nephropathy in an old woman with acute renal failure: a case report and literature review. ( 24845397 )
2014
14
C1q nephropathy- unity in diversity. ( 25340146 )
2013
15
Diverse clinical and histology presentation in c1q nephropathy. ( 24282787 )
2013
16
Concurrent diabetic nephropathy and C1q nephropathy in a young male patient: The first report in literature. ( 24475450 )
2013
17
C1q nephropathy with acute hemolytic uremic syndrome. ( 22569444 )
2012
18
Membranous nephropathy with predominance of C1q: another variant of C1q nephropathy? ( 22595394 )
2012
19
C1q nephropathy presenting as nephritic-nephrotic syndrome. ( 22237242 )
2012
20
C1q nephropathy and malignancy. ( 22466284 )
2012
21
Non-nephronal hematuria misdiagnosed as C1q nephropathy: Look before you leap. ( 23087557 )
2012
22
C1q nephropathy presenting as nephritic-nephrotic syndrome. ( 21566322 )
2011
23
C1q nephropathy presenting as acute renal failure. ( 21912049 )
2011
24
Resolution of clinical and pathologic features of C1q nephropathy after rituximab therapy. ( 21107633 )
2011
25
C1q nephropathy in a patient with Gitelman syndrome. ( 25984202 )
2011
26
C1q nephropathy presenting as acute renal failure. ( 21422635 )
2011
27
C1q nephropathy associated with deletion of long arm of chromosome 7. ( 20642652 )
2010
28
Is collapsing C1q nephropathy another MYH9-associated kidney disease? A case report. ( 20116156 )
2010
29
C1q nephropathy in a child presenting with recurrent gross hematuria. ( 19669167 )
2010
30
C1q nephropathy in the pediatric population: pathology and pathogenesis. ( 20180137 )
2010
31
A single-center study of C1q nephropathy in children. ( 18688655 )
2009
32
C1q nephropathy and minimal change nephrotic syndrome. ( 19082635 )
2009
33
Change in C1q deposition in C1q nephropathy. ( 19288139 )
2009
34
Current status and issues of C1q nephropathy. ( 19373520 )
2009
35
IgG nephropathy - confusion and overlap with C1q nephropathy. ( 19863878 )
2009
36
C1q nephropathy: a true immune complex disease or an immunologic epiphenomenon? ( 25984017 )
2009
37
C1q nephropathy in two young sisters. ( 17952693 )
2008
38
Clinicopathologic correlation and outcome of C1q nephropathy. ( 18650410 )
2008
39
Pathology, clinical presentations, and outcomes of C1q nephropathy. ( 18650484 )
2008
40
Proteinuria in a boy with infectious mononucleosis, C1q nephropathy, and Dent's disease. ( 17982249 )
2007
41
C1q nephropathy in a 2-year-old boy presenting with steroid resistant nephrotic syndrome. ( 21318945 )
2007
42
C1q nephropathy in association with Gitelman syndrome: a case report. ( 16955279 )
2006
43
Clinicopathologic correlation of C1q nephropathy in children. ( 16490619 )
2006
44
C1q nephropathy in a child with a chromosome 13 deletion. ( 16520946 )
2006
45
An 18-year-old woman with proteinuria and renal insufficiency. C1q nephropathy. ( 16594760 )
2006
46
Pediatric C1q nephropathy and incidental proteinuria. ( 16604372 )
2006
47
C1q nephropathy: features at presentation and outcome. ( 15827744 )
2005
48
C1q nephropathy with asymptomatic urine abnormalities. ( 16133042 )
2005
49
C1Q nephropathy in children. ( 16247648 )
2005
50
Distinguishing C1q nephropathy from lupus nephritis. ( 15004260 )
2004

Variations for C1q Nephropathy

Expression for C1q Nephropathy

Search GEO for disease gene expression data for C1q Nephropathy.

Pathways for C1q Nephropathy

GO Terms for C1q Nephropathy

Cellular components related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CD40LG CD79A

Biological processes related to C1q Nephropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.96 CD40LG CD79A
2 B cell proliferation GO:0042100 8.62 CD40LG CD79A

Sources for C1q Nephropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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