CEOT
MCID: CLC010
MIFTS: 29

Calcifying Epithelial Odontogenic Tumor (CEOT)

Categories: Rare diseases

Aliases & Classifications for Calcifying Epithelial Odontogenic Tumor

MalaCards integrated aliases for Calcifying Epithelial Odontogenic Tumor:

Name: Calcifying Epithelial Odontogenic Tumor 53 72
Pindborg Tumor 53
Ceot 53

Classifications:



External Ids:

UMLS 72 C0334574

Summaries for Calcifying Epithelial Odontogenic Tumor

MalaCards based summary : Calcifying Epithelial Odontogenic Tumor, also known as pindborg tumor, is related to ameloblastoma and basal cell nevus syndrome. An important gene associated with Calcifying Epithelial Odontogenic Tumor is AMBN (Ameloblastin), and among its related pathways/superpathways are Pathways in cancer and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Affiliated tissues include bone, salivary gland and eye, and related phenotypes are craniofacial and digestive/alimentary

Wikipedia : 75 The calcifying epithelial odontogenic tumor (CEOT), also known as a Pindborg tumor, is an odontogenic... more...

Related Diseases for Calcifying Epithelial Odontogenic Tumor

Diseases related to Calcifying Epithelial Odontogenic Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 ameloblastoma 30.0 PTCH1 KRT8 AMBN
2 basal cell nevus syndrome 29.9 PTCH1 GLI2
3 keratocystic odontogenic tumor 29.8 TP53 PTCH1
4 basal cell carcinoma 28.5 TP53 PTCH1 KRT8 GLI2
5 rare tumor 10.4
6 rapidly involuting congenital hemangioma 10.3
7 persistent idiopathic facial pain 10.1
8 tuberous sclerosis 1 10.1
9 myeloma, multiple 10.1
10 osteogenic sarcoma 10.1
11 fibroma 10.1
12 osteoblastoma 10.1
13 tuberous sclerosis 10.1
14 root resorption 10.1
15 acinar cell carcinoma 10.1
16 clear cell adenocarcinoma 10.1
17 mucoepidermoid carcinoma 10.1
18 myoepithelial carcinoma 10.1
19 epithelial-myoepithelial carcinoma 10.1
20 hard palate cancer 10.1
21 nasal cavity neoplasm 10.1
22 exophthalmos 10.1
23 stomatitis 10.1
24 ulcerative stomatitis 10.1
25 47,xyy 10.1
26 pyogenic granuloma 10.1
27 posttransplant acute limbic encephalitis 10.1
28 rare odontogenic tumor 10.1
29 focal epithelial hyperplasia 10.0 TP53 GLI2
30 prostate squamous cell carcinoma 10.0 TP53 KRT8
31 pleomorphic carcinoma 10.0 TP53 KRT8
32 basaloid squamous cell carcinoma 10.0 TP53 KRT8
33 adenosquamous carcinoma 9.9 TP53 KRT8
34 cervical squamous cell carcinoma 9.9 TP53 KRT8
35 sweat gland cancer 9.9 TP53 KRT8
36 holoprosencephaly, recurrent infections, and monocytosis 9.9 PTCH1 GLI2
37 holoprosencephaly 9.9 PTCH1 GLI2
38 midline interhemispheric variant of holoprosencephaly 9.8 PTCH1 GLI2
39 septopreoptic holoprosencephaly 9.8 PTCH1 GLI2
40 nodular medulloblastoma 9.8 PTCH1 GLI2
41 alobar holoprosencephaly 9.8 PTCH1 GLI2
42 lobar holoprosencephaly 9.8 PTCH1 GLI2
43 merkel cell carcinoma 9.8 TP53 KRT8
44 microform holoprosencephaly 9.8 PTCH1 GLI2
45 semilobar holoprosencephaly 9.8 PTCH1 GLI2
46 ductal carcinoma in situ 9.8 TP53 KRT8
47 cerebellar liponeurocytoma 9.8 TP53 PTCH1
48 greig cephalopolysyndactyly syndrome 9.8 PTCH1 GLI2
49 childhood medulloblastoma 9.8 TP53 PTCH1
50 adult medulloblastoma 9.8 TP53 PTCH1

Graphical network of the top 20 diseases related to Calcifying Epithelial Odontogenic Tumor:



Diseases related to Calcifying Epithelial Odontogenic Tumor

Symptoms & Phenotypes for Calcifying Epithelial Odontogenic Tumor

MGI Mouse Phenotypes related to Calcifying Epithelial Odontogenic Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.71 AMBN GLI2 PTCH1 TP53
2 digestive/alimentary MP:0005381 9.67 GLI2 KRT8 PTCH1 TP53
3 growth/size/body region MP:0005378 9.65 AMBN GLI2 KRT8 PTCH1 TP53
4 embryo MP:0005380 9.62 GLI2 KRT8 PTCH1 TP53
5 hearing/vestibular/ear MP:0005377 9.46 GLI2 KRT8 PTCH1 TP53
6 reproductive system MP:0005389 9.26 GLI2 KRT8 PTCH1 TP53
7 skeleton MP:0005390 8.92 AMBN GLI2 PTCH1 TP53

Drugs & Therapeutics for Calcifying Epithelial Odontogenic Tumor

Search Clinical Trials , NIH Clinical Center for Calcifying Epithelial Odontogenic Tumor

Genetic Tests for Calcifying Epithelial Odontogenic Tumor

Anatomical Context for Calcifying Epithelial Odontogenic Tumor

MalaCards organs/tissues related to Calcifying Epithelial Odontogenic Tumor:

41
Bone, Salivary Gland, Eye

Publications for Calcifying Epithelial Odontogenic Tumor

Articles related to Calcifying Epithelial Odontogenic Tumor:

(show top 50) (show all 254)
# Title Authors PMID Year
1
What Is the Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor? 38
30284106 2019
2
Who Originally Described Pindborg Tumor? 38
30027385 2019
3
Synchronous Calcifying Epithelial Odontogenic Tumor: Case Report and Analysis of the 5 Cases in the Literature. 38
31352628 2019
4
Multiple calcifying epithelial odontogenic tumor: case report and review of the literature. 38
31078504 2019
5
Calcifying Epithelial Odontogenic (Pindborg) Tumor in a Child: A Case Report and Literature Review. 38
30771214 2019
6
Surgical management of a large calcifying epithelial odontogenic tumor in the maxilla: A case report. 38
30981981 2019
7
Microcystic Calcifying Epithelial Odontogenic Tumor. 38
29164474 2018
8
A clinicopathologic study on central odontogenic fibroma: with special reference to amyloid variant. 38
30291007 2018
9
Benign and malignant odontogenic neoplasms of the jaws show a concordant nondiscriminatory p63/p40 positive immunophenotype. 38
30309829 2018
10
A radiolucent lesion presenting calcification histopathologically: a classical case of CEOT. 38
30476388 2018
11
Clinical and Histopathological Analysis of Odontogenic Tumors in Institution-A 10 Years Retrospective Study. 38
30498188 2018
12
Peripheral clear cell variant of calcifying epithelial odontogenic tumor devoid of calcification. 38
29695670 2018
13
Non-calcifying Langerhans Cell-Rich Variant of Calcifying Epithelial Odontogenic Tumor: A Distinct Entity with Predilection for Anterior Maxilla. 38
30109555 2018
14
Pindborg tumor: Pathology with special stains. 38
29676366 2018
15
Peripheral variant of calcifying epithelial odontogenic tumor with clear cell changes: An enigma. 38
29676382 2018
16
Ghost cell odontogenic carcinoma with suspected cholesterol granuloma of the maxillary sinus in a patient treated with combined modality therapy: A case report and the review of literature. 38
29443742 2018
17
A Combined Epithelial Odontogenic Tumor? A 7-Year Follow-Up Case. 38
27817004 2017
18
Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: A Case Report and Preliminary Immunohistochemical Study of the SHH Pathway. 38
27941562 2017
19
Calcifying epithelial odontogenic tumor: An updated analysis of 339 cases reported in the literature. 38
28601296 2017
20
A unique case of clear cell variant of calcifying epithelial odontogenic tumor involving the maxilla. 38
28928785 2017
21
Non Calcifying Type of Calcifying Epithelial Odontogenic Tumor: An Unusual Case Report with Special Emphasis on Histogenesis of Calcifications. 38
28439170 2017
22
Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: A Rare Clinical Entity. 38
28798004 2017
23
Odontogenic Cysts and Neoplasms. 38
28153133 2017
24
Pindborg tumor in the distal femur. 38
28409146 2017
25
Peripheral Clear Cell Variant of Calcifying Epithelial Odontogenic Tumor: Case Report and Review of the Literature. 38
27154023 2016
26
Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study. 38
27871286 2016
27
Clear cell variant of intraosseous calcifying epithelial odontogenic tumor: a case report and review of the literature. 38
26953043 2016
28
Pigmented Pindborg tumor of the maxilla: A case report. 38
27721633 2016
29
Pindborg Tumor Presenting as a Nasal Polyp: Immunohistology and Ultrastructural Features of a Rare Case, With Review of the Literature. 38
27098590 2016
30
Mandibular intraosseous pseudocarcinomatous hyperplasia: a case report. 38
27680099 2016
31
Maxillary Calcifying Epithelial Odontogenic Tumour. 38
27935922 2016
32
Non-calcifying and Langerhans cell-rich variant of calcifying epithelial odontogenic tumor. 38
30894958 2016
33
Kallikrein 4 and matrix metalloproteinase-20 immunoexpression in malignant, benign and infiltrative odontogenic tumors. 38
27601817 2016
34
Aggressive Calcifying Epithelial Odontogenic Tumor of the Maxillary Sinus with Extraosseous Oral Mucosal Involvement: A Case Report. 38
26989286 2016
35
[Calcifying epithelial odontogenic tumor: two cases report]. 38
27266209 2016
36
Pindborg tumor. 38
27041911 2016
37
Report of Two Cases of Combined Odontogenic Tumors: Ameloblastoma with Odontogenic Keratocyst and Ameloblastic Fibroma with Calcifying Odontogenic Cyst. 38
25552434 2015
38
Noncalcifying variant of calcifying epithelial odontogenic tumor with Langerhans cells. 38
25997388 2015
39
Cystic Variant of Calcifying Epithelial Odontogenic Tumor. 38
26167990 2015
40
A rare case of hybrid odontogenic tumor: Calcifying epithelial odontogenic tumor combined with ameloblastoma. 38
26604514 2015
41
Intraosseous calcifying epithelial odontogenic (Pindborg) tumor: A rare entity. 38
26604515 2015
42
Treatment of calcifying epithelial odontogenic tumor/Pindborg tumor by a conservative surgical method. 38
26015736 2015
43
Clear cell variant of calcifying epithelial odontogenic tumor: Case report with immunohistochemical findings. 38
25810830 2015
44
Calcifying epithelial odontogenic tumor: report of a recurrent destructive case with review of literature. 38
26005457 2015
45
[CEOT - Calcified anomalies in dental X-ray. A case-based review of differential diagnoses in radiopaque lesions in maxilla and mandible]. 38
26168688 2015
46
Maxillary Calcifying Epithelial Odontogenic Tumor in a Siberian Tiger (Panthera tigris altaica). 38
26415389 2015
47
Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors. 38
25364178 2014
48
Gingival calcifying epithelial tumor - a rare case report. 38
25855116 2014
49
Current Concepts and Occurrence of Epithelial Odontogenic Tumors: II. Calcifying Epithelial Odontogenic Tumor Versus Ghost Cell Odontogenic Tumors Derived from Calcifying Odontogenic Cyst. 38
25013415 2014
50
Pindborg tumor arising in association with an impacted supernumerary tooth in the anterior maxilla. 38
25007464 2014

Variations for Calcifying Epithelial Odontogenic Tumor

Expression for Calcifying Epithelial Odontogenic Tumor

Search GEO for disease gene expression data for Calcifying Epithelial Odontogenic Tumor.

Pathways for Calcifying Epithelial Odontogenic Tumor

Pathways related to Calcifying Epithelial Odontogenic Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.22 TP53 PTCH1 GLI2
2
Show member pathways
11.29 TP53 PTCH1 GLI2
3 10.85 PTCH1 GLI2
4 10.7 TP53 KRT8
5
Show member pathways
10.43 PTCH1 GLI2

GO Terms for Calcifying Epithelial Odontogenic Tumor

Cellular components related to Calcifying Epithelial Odontogenic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear matrix GO:0016363 8.62 TP53 KRT8

Biological processes related to Calcifying Epithelial Odontogenic Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.7 TP53 PTCH1 GLI2
2 positive regulation of transcription, DNA-templated GO:0045893 9.69 TP53 PTCH1 GLI2
3 smoothened signaling pathway GO:0007224 9.49 PTCH1 GLI2
4 pattern specification process GO:0007389 9.48 PTCH1 GLI2
5 odontogenesis of dentin-containing tooth GO:0042475 9.46 GLI2 AMBN
6 cell proliferation GO:0008283 9.43 TP53 GLI2
7 dorsal/ventral pattern formation GO:0009953 9.4 PTCH1 GLI2
8 mammary gland development GO:0030879 9.37 PTCH1 GLI2
9 spinal cord motor neuron differentiation GO:0021522 9.26 PTCH1 GLI2
10 dorsal/ventral neural tube patterning GO:0021904 9.16 PTCH1 GLI2
11 regulation of smoothened signaling pathway GO:0008589 9.02 PTCH1
12 smoothened signaling pathway involved in dorsal/ventral neural tube patterning GO:0060831 8.96 PTCH1 GLI2
13 mammary gland duct morphogenesis GO:0060603 8.62 PTCH1 GLI2

Molecular functions related to Calcifying Epithelial Odontogenic Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 promoter-specific chromatin binding GO:1990841 8.62 TP53 GLI2

Sources for Calcifying Epithelial Odontogenic Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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