MCID: CLC006
MIFTS: 53

Calcinosis

Categories: Metabolic diseases

Aliases & Classifications for Calcinosis

MalaCards integrated aliases for Calcinosis:

Name: Calcinosis 12 30 56 45 15 74
Pathologically Calcified Structure 12
Pathologic Calcification 12

Classifications:



External Ids:

Disease Ontology 12 DOID:182
MeSH 45 D002114
NCIt 51 C3672
SNOMED-CT 69 6595006
UMLS 74 C0006663

Summaries for Calcinosis

Disease Ontology : 12 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.

MalaCards based summary : Calcinosis, also known as pathologically calcified structure, is related to tumoral calcinosis, hyperphosphatemic, familial, 1 and tumoral calcinosis, normophosphatemic, familial. An important gene associated with Calcinosis is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways are Degradation of the extracellular matrix and Endochondral Ossification. The drugs Phylloquinone and Menaquinone have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 77 Calcinosis is the formation of calcium deposits in any soft tissue. It is a rare condition that has many... more...

Related Diseases for Calcinosis

Diseases related to Calcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
# Related Disease Score Top Affiliating Genes
1 tumoral calcinosis, hyperphosphatemic, familial, 1 34.5 FGF23 GALNT3 KL SAMD9
2 tumoral calcinosis, normophosphatemic, familial 33.4 CALCA GALNT3 RGL2 SAMD9 SAMD9L
3 familial tumoral calcinosis 33.0 FGF23 GALNT3 KL PHEX RGL2 SAMD9
4 mandibuloacral dysplasia with type a lipodystrophy 32.8 LMNA ZMPSTE24
5 reynolds syndrome 31.7 LMNA ZMPSTE24
6 hyperostosis 30.6 FGF23 GALNT3 KL
7 hyperparathyroidism 30.5 CALCA FGF23 PHEX
8 hyperphosphatemia 30.3 FGF23 GALNT3 KL MGP PHEX
9 hypervitaminosis d 30.2 FGF23 GALNT3 KL
10 acroosteolysis 30.0 LMNA ZMPSTE24
11 arteriosclerosis 29.9 KL MGP SPP1
12 pseudoxanthoma elasticum 29.9 ENPP1 FBN1 MGP SPP1
13 skin atrophy 29.8 KL LMNA
14 chronic kidney failure 29.5 CALCA FGF23 SPP1
15 hypophosphatemia 29.5 DMP1 ENPP1 FGF23 PHEX
16 hutchinson-gilford progeria syndrome 29.4 ENPP1 LMNA ZMPSTE24
17 mineral metabolism disease 29.2 CALCA FGF23 GALNT3 KL PHEX
18 osteoporosis 28.8 AHSG CALCA FGF23 KL MGP SPARC
19 tumoral calcinosis, hyperphosphatemic, familial, 2 12.6
20 tumoral calcinosis, hyperphosphatemic, familial, 3 12.6
21 crest syndrome 12.0
22 basal ganglia calcification, idiopathic, 1 11.7
23 basal ganglia calcification, idiopathic, childhood-onset 11.7
24 dermatomyositis 11.6
25 scleroderma, familial progressive 11.5
26 primary familial brain calcification 11.4
27 poikiloderma with neutropenia 11.3
28 nephrocalcinosis 11.3
29 cole disease 11.2
30 diffuse idiopathic skeletal hyperostosis 11.0
31 childhood type dermatomyositis 10.6
32 lupus erythematosus 10.4
33 tracheal calcification 10.4 FGF23 KL
34 systemic scleroderma 10.4
35 systemic lupus erythematosus 10.4
36 raine syndrome 10.3 DMP1 FGF23
37 adult dermatomyositis 10.3
38 opsismodysplasia 10.3 FGF23 PHEX
39 dentin dysplasia, type ii 10.3 DMP1 SPP1
40 down syndrome 10.3
41 arthritis 10.3
42 prolapse of female genital organ 10.2 LMNA SPARC
43 papillary cystadenocarcinoma 10.2 SPARC SPP1
44 connective tissue disease 10.2
45 hypoparathyroidism 10.2
46 hypophosphatemic rickets, autosomal dominant 10.2 FGF23 GALNT3 PHEX
47 secondary hypertrophic osteoarthropathy 10.2 CALCA GALNT3
48 rheumatoid arthritis 10.2
49 telangiectasis 10.2
50 enthesopathy 10.1 DMP1 FGF23 PHEX

Graphical network of the top 20 diseases related to Calcinosis:



Diseases related to Calcinosis

Symptoms & Phenotypes for Calcinosis

MGI Mouse Phenotypes related to Calcinosis:

47 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 AHSG DMP1 ENPP1 FBN1 FGF23 GALNT3
2 homeostasis/metabolism MP:0005376 10.3 AHSG DMP1 ENPP1 FBN1 FGF23 GALNT3
3 cardiovascular system MP:0005385 10.29 DMP1 ENPP1 FBN1 FGF23 GALNT3 KL
4 hematopoietic system MP:0005397 10.22 DMP1 FBN1 FGF23 GALNT3 KL LMNA
5 immune system MP:0005387 10.21 DMP1 ENPP1 FBN1 FGF23 GALNT3 KL
6 cellular MP:0005384 10.19 DMP1 ENPP1 FBN1 GALNT3 KL LMNA
7 craniofacial MP:0005382 10.18 DMP1 FBN1 GALNT3 KL LMNA PHEX
8 limbs/digits/tail MP:0005371 10.11 AHSG DMP1 ENPP1 FBN1 FGF23 GALNT3
9 integument MP:0010771 10.1 ENPP1 FBN1 FGF23 GALNT3 KL LMNA
10 adipose tissue MP:0005375 10.03 ENPP1 FBN1 KL LMNA PHEX ZMPSTE24
11 muscle MP:0005369 9.91 AHSG ENPP1 FBN1 GALNT3 KL LMNA
12 renal/urinary system MP:0005367 9.9 DMP1 ENPP1 FBN1 FGF23 GALNT3 KL
13 hearing/vestibular/ear MP:0005377 9.89 AHSG ENPP1 KL LMNA PHEX
14 liver/biliary system MP:0005370 9.8 ENPP1 KL LMNA PHEX SPP1 ZMPSTE24
15 skeleton MP:0005390 9.44 AHSG DMP1 ENPP1 FBN1 FGF23 GALNT3
16 respiratory system MP:0005388 9.43 FBN1 FGF23 KL LMNA MGP SPP1

Drugs & Therapeutics for Calcinosis

Drugs for Calcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 380)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Phylloquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84-80-0
2 Menaquinone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1182-68-9
3
Warfarin Approved Phase 4 81-81-2 54678486 6691
4
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
5
Rivaroxaban Approved Phase 4 366789-02-8
6 fluindione Approved, Investigational Phase 4 957-56-2
7
Alendronate Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 66376-36-1, 121268-17-5 2088
8
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 32051
9
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
10
Denosumab Approved Phase 4,Phase 3,Phase 2 615258-40-7
11
Sirolimus Approved, Investigational Phase 4,Not Applicable 53123-88-9 46835353 5284616 6436030
12
Everolimus Approved Phase 4,Not Applicable 159351-69-6 70789204 6442177
13
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
14
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 122320-73-4 77999
15
Sevelamer Approved Phase 4,Phase 3,Phase 2,Not Applicable 52757-95-6
16
Atorvastatin Approved Phase 4,Phase 3,Phase 2 134523-00-5 60823
17
Pravastatin Approved Phase 4 81093-37-0 54687
18
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
19
Ofloxacin Approved Phase 4 82419-36-1 4583
20
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
21
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
22
Cinacalcet Approved Phase 4,Phase 3,Not Applicable 226256-56-0 156419
23
Calcium acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 62-54-4
24
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
25
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
26
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
27
Methyltestosterone Approved Phase 4 58-18-4 6010
28
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
29
Testosterone enanthate Approved Phase 4 315-37-7 9416
30
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9002-64-6
31
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 137-58-6 3676
32
Leflunomide Approved, Investigational Phase 4 75706-12-6 3899
33
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
34
Triamcinolone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 124-94-7 31307
35
Mycophenolic acid Approved Phase 4,Not Applicable 24280-93-1 446541
36
Apixaban Approved Phase 4 503612-47-3 10182969
37
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
38
Adenosine Approved, Investigational Phase 4 58-61-7 60961
39
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
40
Prednisolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 50-24-8 5755
41
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 1,Not Applicable 302-25-0
42
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 83-43-2 6741
43
Methylprednisolone hemisuccinate Approved Phase 4,Phase 1,Not Applicable 2921-57-5
44
Simvastatin Approved Phase 4 79902-63-9 54454
45
Amlodipine Approved Phase 4 88150-42-9 2162
46
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
47
Ticlopidine Approved Phase 4 55142-85-3 5472
48
Chromium Approved Phase 4,Not Applicable 7440-47-3 27668
49
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
50
Metformin Approved Phase 4,Phase 3,Phase 2,Not Applicable 657-24-9 14219 4091

Interventional clinical trials:

(show top 50) (show all 603)
# Name Status NCT ID Phase Drugs
1 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
2 Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation Unknown status NCT02161965 Phase 4 Rivaroxaban;Fluindione;Warfarin
3 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
4 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
5 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
6 Effects of Cholecalciferol on Osteoprotegerin Levels in Patients on Peritoneal Dialysis Unknown status NCT02598635 Phase 4 Cholecalciferol;Placebo
7 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4 Calcitriol;placebo
8 Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease Unknown status NCT02792413 Phase 4 Denosumab;NaCl (placebo)
9 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
10 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
11 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
12 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
13 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
14 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
15 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
16 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
17 Adverse Plaque Characteristics in CCTA and TVC Imaging Unknown status NCT02350959 Phase 4 Atorvastatin;Atorvastatin
18 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
19 Efficiency Study of Aspirin to Prevent the Occurrence of Prostate Cancer Unknown status NCT02757365 Phase 4 aspirin;Levofloxacin
20 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Completed NCT02610933 Phase 4 rivaroxaban
21 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4 Menaquinone
22 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
23 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
24 Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque Completed NCT02090075 Phase 4 apixaban;warfarin
25 Can Alendronate Suppress Calcification and Improve Bone Density in Chronic Peritoneal Dialysis Patients? Completed NCT00261625 Phase 4 alendronate
26 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
27 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4 calcium acetate;sevelamer;atorvastatin
28 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
29 Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients Completed NCT00745225 Phase 4 Pioglitazone;placebo comparator
30 The XLIMUS-DES in Very Complex Lesions Completed NCT02360020 Phase 4
31 Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY) Completed NCT00295191 Phase 4
32 Sevelamer, Fetuin-A and Endothelial Dysfunction in CKD Completed NCT00486772 Phase 4 Sevelamer (Renagel), calcium acetate (Phos-ex)
33 Sevelamer, FGF-23 and Endothelial Dysfunction in Chronic Kidney Disease (CKD) Completed NCT01135615 Phase 4 Sevelamer;calcium acetate
34 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4 Regadenoson myocardial perfusion imaging;Regadenoson MRI myocardial blood flow
35 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Completed NCT02376010 Phase 4 rivaroxaban;Warfarin
36 Effect of Atorvastatin on Bone-vascular Axis Completed NCT02342015 Phase 4 Atorvastatin
37 Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol Completed NCT01748396 Phase 4 Calcitriol;Calcium Carbonate
38 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Completed NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
39 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4 Statin (simvastatin)
40 REmoval of Free Light Chains. A COmpaRison of Three Different dialyzERs Completed NCT02950389 Phase 4
41 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4 Cinacalcet
42 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure Completed NCT00124969 Phase 4 Amlodipine;Placebo
43 PROMUS Element Plus US Post-Approval Study Completed NCT01589978 Phase 4 Aspirin;P2Y12 antagonist
44 Effect of Aged Garlic Extract on Atherosclerosis Completed NCT01534910 Phase 4 aged garlic extract;placebo
45 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
46 Rosuvastatin in the Long-term Treatment of Hypercholesterolaemic Subjects With Coronary Heart Disease Completed NCT00329160 Phase 4 Rosuvastatin;HMG CoA inhibitor
47 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4 cinacalcet;control
48 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
49 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
50 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4 Atorvastatin

Search NIH Clinical Center for Calcinosis

Cochrane evidence based reviews: calcinosis

Genetic Tests for Calcinosis

Genetic tests related to Calcinosis:

# Genetic test Affiliating Genes
1 Calcinosis 30

Anatomical Context for Calcinosis

MalaCards organs/tissues related to Calcinosis:

42
Kidney, Bone, Breast, Heart, Brain, Thyroid, Endothelial

Publications for Calcinosis

Articles related to Calcinosis:

(show top 50) (show all 1775)
# Title Authors Year
1
Scrotal calcinosis in an adult patient with amyopathic dermatomyositis. ( 29945258 )
2019
2
Hyperphosphatemic Familial Tumoral Calcinosis in Two Siblings with a Novel Mutation in GALNT3 Gene: Experience from Southern Turkey ( 30015621 )
2019
3
Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome. ( 30194873 )
2019
4
131I uptake in tumoral calcinosis in a patient on hemodialysis treated for thyroid cancer. ( 30291041 )
2019
5
Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy. ( 30447023 )
2019
6
Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor. ( 30476938 )
2019
7
Calcinosis Cutis of the Vulva: A Review. ( 30586019 )
2019
8
Tumoral calcinosis of the lumbar and cervical spine. ( 30612912 )
2019
9
Hyperphosphataemic tumoral calcinosis. ( 30638581 )
2019
10
Effectiveness and safety of rituximab for the treatment of refractory systemic sclerosis associated calcinosis: A case series and systematic review of the literature. ( 30639647 )
2019
11
An unusual case of idiopathic calcinosis of the eyelid. ( 30644795 )
2019
12
Idiopathic tumoral calcinosis presenting in early childhood. ( 30679229 )
2019
13
Giant thoracic calcinosis: a dermatomyositis manifestation. ( 30715552 )
2019
14
Inflammatory Activity of Tumoral Calcinosis in a Patient With Fever of Unknown Origin. ( 30762827 )
2019
15
Gargantuan primary scrotal calcinosis - Surgical, cosmetic, and sociopsychiatric concern. ( 30787579 )
2019
16
Association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis-related calcinosis. ( 30789234 )
2019
17
Metastatic calcinosis cutis due to refractory hypercalcaemia responsive to denosumab in a patient with multiple sclerosis. ( 30804155 )
2019
18
FDG-PET detects extensive calcinosis cutis in anti-NXP2 antibody-positive dermatomyositis. ( 30879053 )
2019
19
Huge tumoral calcinosis mimicking a sarcoma. ( 30971573 )
2019
20
Imaging calcinosis in patients with systemic sclerosis by radiography, computerised tomography and magnetic resonance imaging. ( 30981516 )
2019
21
Diffuse tracheobronchial calcinosis in a geriatric patient with chronic kidney disease. ( 31031358 )
2019
22
Sodium thiosulfate dressings facilitate healing of refractory cutaneous ulcers of calcinosis cutis. ( 31036781 )
2019
23
Soft Tissue Calcinosis Universalis Visualized with Novel 3-D Computed Tomography Cinematic Rendering. ( 31043499 )
2019
24
Complete Resolution of Tumoral Calcinosis in a Patient on Peritoneal Dialysis with Cinacalcet. ( 31088935 )
2019
25
Successful treatment of extensive uremic calciphylaxis with intravenous sodium thiosulfate and its potential in treating various diseases of pathologic calcification. ( 30901068 )
2019
26
Asymmetric Calcinosis in an Adult Patient With Antisynthetase Syndrome. ( 29319552 )
2018
27
Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report. ( 30461645 )
2018
28
Dystrophic calcinosis cutis within burns, successfully treated with excision and secondary intention wound healing. ( 29430689 )
2018
29
Big Gain, No Pain: Tumoral Calcinosis. ( 28923522 )
2018
30
Lethal Visceral Calcinosis in Fulminant Hypercalcemic Crisis. ( 29093412 )
2018
31
Characterization of a Pseudoxanthoma elasticum-like patient with coagulation deficiency, cutaneous calcinosis and GGCX compound heterozygosity. ( 29175035 )
2018
32
Bilateral striopallidodentate calcinosis associated with Sjögren's syndrome and IgDλ monoclonal gammopathy of undetermined significance. ( 29183861 )
2018
33
Enzootic calcinosis in horses grazing Solanum glaucophyllum in Argentina. ( 29202673 )
2018
34
Mönckeberg medial calcinosis of the infraorbital arteries: a first case report. ( 29248421 )
2018
35
Secondary Calcinosis of the Foot. ( 29292317 )
2018
36
Calcinosis Cutis: WOC Nurse Management. ( 29300294 )
2018
37
Systemic Calcinosis in NXP2-Dermatomyositis. ( 29319550 )
2018
38
Added value of newer optical coherence tomography technologies in hyperphosphatemic familial tumoural calcinosis. ( 29426463 )
2018
39
Calcinosis cutis universalis in systemic sclerosis. ( 29451139 )
2018
40
Idiopathic scrotal calcinosis - A case report. ( 29477103 )
2018
41
Idiopathic Scrotal Calcinosis - A Case Report. ( 29484000 )
2018
42
Dermoscopic features of Milia-Like calcinosis cutis. ( 29512978 )
2018
43
Dialysis as a Treatment Option for a Patient With Normal Kidney Function and Familial Tumoral Calcinosis Due to a Compound Heterozygous FGF23 Mutation. ( 29548779 )
2018
44
Extensive calcinosis cutis in a patient with systemic lupus erythematosus: An exceptional complication. ( 29555168 )
2018
45
Calcinosis of the Mandible in Dermatomyositis. ( 29579373 )
2018
46
Calcinosis Cutis and Negative Pressure Wound Therapy as Adjuncts to Surgical Management: Case Report and Review of the Literature. ( 29584607 )
2018
47
Hyperphosphatemic tumoral calcinosis caused by FGF23 compound heterozygous mutations: what are the therapeutic options for a better control of phosphatemia? ( 29594503 )
2018
48
Facial Calcinosis Cutis in a Woman with Paraneoplastic Dermatomyositis. ( 29598989 )
2018
49
Scrotal Calcinosis in Brothers. ( 29606827 )
2018
50
Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis. ( 29622763 )
2018

Variations for Calcinosis

Expression for Calcinosis

Search GEO for disease gene expression data for Calcinosis.

Pathways for Calcinosis

Pathways related to Calcinosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 DMP1 FBN1 SPARC SPP1
2 10.61 ENPP1 MGP SPP1

GO Terms for Calcinosis

Cellular components related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 AHSG CALCA ENPP1 FBN1 FGF23 KL
2 collagen-containing extracellular matrix GO:0062023 9.62 AHSG FBN1 MGP SPARC
3 extracellular matrix GO:0031012 9.46 DMP1 FBN1 MGP SPARC
4 endoplasmic reticulum lumen GO:0005788 9.35 AHSG DMP1 FBN1 FGF23 SPP1
5 extracellular region GO:0005576 9.32 AHSG CALCA DMP1 ENPP1 FBN1 FGF23

Biological processes related to Calcinosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.83 CALCA FBN1 FGF23 KL SPP1
2 skeletal system development GO:0001501 9.77 AHSG FBN1 PHEX
3 post-translational protein modification GO:0043687 9.77 AHSG DMP1 FBN1 FGF23 SPP1
4 extracellular matrix organization GO:0030198 9.76 DMP1 FBN1 SPARC SPP1
5 fibroblast growth factor receptor signaling pathway GO:0008543 9.7 FGF23 GALNT3 KL
6 nucleus organization GO:0006997 9.6 LMNA ZMPSTE24
7 negative regulation of osteoclast differentiation GO:0045671 9.58 CALCA FBN1
8 phosphate-containing compound metabolic process GO:0006796 9.58 ENPP1 FGF23
9 response to vitamin D GO:0033280 9.57 PHEX SPP1
10 nuclear envelope organization GO:0006998 9.56 LMNA ZMPSTE24
11 ossification GO:0001503 9.56 AHSG DMP1 MGP SPARC
12 negative regulation of bone mineralization GO:0030502 9.55 AHSG FGF23
13 cellular response to vitamin D GO:0071305 9.54 FGF23 PHEX
14 cellular response to parathyroid hormone stimulus GO:0071374 9.51 FGF23 PHEX
15 endosomal vesicle fusion GO:0034058 9.49 SAMD9 SAMD9L
16 cellular phosphate ion homeostasis GO:0030643 9.48 ENPP1 FGF23
17 biomineral tissue development GO:0031214 9.46 DMP1 ENPP1 PHEX SPP1
18 cellular protein metabolic process GO:0044267 9.43 AHSG CALCA DMP1 FBN1 FGF23 SPP1
19 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.4 FGF23 KL
20 response to sodium phosphate GO:1904383 9.32 FGF23 PHEX
21 regulation of bone mineralization GO:0030500 9.02 AHSG ENPP1 FGF23 MGP ZMPSTE24

Molecular functions related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.43 DMP1 ENPP1 FBN1 GALNT3 MGP SPARC
2 hormone activity GO:0005179 9.33 CALCA FBN1 KL
3 fibroblast growth factor receptor binding GO:0005104 9.32 FGF23 KL
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 8.96 RGL2
5 extracellular matrix binding GO:0050840 8.8 DMP1 SPARC SPP1

Sources for Calcinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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