MCID: CLC006
MIFTS: 48

Calcinosis

Categories: Metabolic diseases

Aliases & Classifications for Calcinosis

MalaCards integrated aliases for Calcinosis:

Name: Calcinosis 12 29 55 44 15 73
Pathologically Calcified Structure 12
Pathologic Calcification 12

Classifications:



External Ids:

Disease Ontology 12 DOID:182
MeSH 44 D002114
NCIt 50 C3672
SNOMED-CT 68 6595006
UMLS 73 C0006663

Summaries for Calcinosis

Disease Ontology : 12 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.

MalaCards based summary : Calcinosis, also known as pathologically calcified structure, is related to tumoral calcinosis, hyperphosphatemic, familial, 1 and tumoral calcinosis, normophosphatemic, familial. An important gene associated with Calcinosis is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways is Endochondral Ossification. The drugs Warfarin and Phytonadione have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Calcinosis is the formation of calcium deposits in any soft... more...

Related Diseases for Calcinosis

Diseases related to Calcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 tumoral calcinosis, hyperphosphatemic, familial, 1 34.3 FGF23 GALNT3 KL SAMD9
2 tumoral calcinosis, normophosphatemic, familial 33.5 CALCA GALNT3 RGL2 SAMD9 SAMD9L
3 familial tumoral calcinosis 33.1 FGF23 GALNT3 KL PHEX RGL2 SAMD9
4 hyperphosphatemia 30.3 FGF23 GALNT3 KL MGP PHEX
5 hyperparathyroidism 30.1 CALCA FGF23 PHEX
6 hypervitaminosis d 30.0 FGF23 GALNT3 KL
7 hyperostosis 30.0 ANKH FGF23 GALNT3 KL
8 skin atrophy 29.7 KL LMNA
9 arteriosclerosis 29.6 KL MGP SPP1
10 chronic kidney failure 29.6 CALCA FGF23 SPP1
11 hypophosphatemia 29.6 ENPP1 FGF23 PHEX
12 secondary hyperparathyroidism of renal origin 29.6 CALCA FGF23
13 pseudoxanthoma elasticum 29.5 ANKH ENPP1 FBN1 MGP SPP1
14 mineral metabolism disease 29.3 CALCA FGF23 GALNT3 KL PHEX
15 osteoporosis 29.0 AHSG CALCA FGF23 KL MGP SPARC
16 tumoral calcinosis, hyperphosphatemic, familial, 2 12.4
17 tumoral calcinosis, hyperphosphatemic, familial, 3 12.4
18 crest syndrome 12.0
19 basal ganglia calcification, idiopathic, childhood-onset 11.7
20 mandibuloacral dysplasia with type a lipodystrophy 11.6
21 dermatomyositis 11.6
22 familial idiopathic basal ganglia calcification 11.5
23 scleroderma, familial progressive 11.4
24 basal ganglia calcification, idiopathic, 1 11.3
25 poikiloderma with neutropenia 11.3
26 nephrocalcinosis 11.3
27 primary familial brain calcification 11.2
28 reynolds syndrome 11.1
29 cole disease 11.1
30 diffuse idiopathic skeletal hyperostosis 11.0
31 childhood type dermatomyositis 10.6
32 lupus erythematosus 10.3
33 systemic lupus erythematosus 10.3
34 tracheal calcification 10.3 FGF23 KL
35 adult dermatomyositis 10.2
36 down syndrome 10.2
37 systemic scleroderma 10.2
38 connective tissue disease 10.2
39 opsismodysplasia 10.2 FGF23 PHEX
40 hypophosphatasia 10.2 ENPP1 PHEX
41 hypoparathyroidism 10.2
42 enthesopathy 10.1 FGF23 PHEX
43 prolapse of female genital organ 10.1 LMNA SPARC
44 papillary cystadenocarcinoma 10.1 SPARC SPP1
45 oncogenic osteomalacia 10.1 FGF23 PHEX
46 myositis 10.1
47 arthritis 10.1
48 secondary hypertrophic osteoarthropathy 10.1 CALCA GALNT3
49 hypercementosis 10.1 ENPP1 SPP1
50 hypophosphatemic rickets, autosomal dominant 10.1 FGF23 GALNT3 PHEX

Graphical network of the top 20 diseases related to Calcinosis:



Diseases related to Calcinosis

Symptoms & Phenotypes for Calcinosis

MGI Mouse Phenotypes related to Calcinosis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.3 AHSG ANKH ENPP1 FBN1 FGF23 GALNT3
2 homeostasis/metabolism MP:0005376 10.29 AHSG ANKH ENPP1 FBN1 FGF23 GALNT3
3 cardiovascular system MP:0005385 10.25 ANKH ENPP1 FBN1 FGF23 GALNT3 KL
4 immune system MP:0005387 10.2 ANKH ENPP1 FBN1 FGF23 GALNT3 KL
5 hematopoietic system MP:0005397 10.19 ANKH FBN1 FGF23 GALNT3 KL LMNA
6 craniofacial MP:0005382 10.14 ANKH FBN1 GALNT3 KL LMNA PHEX
7 limbs/digits/tail MP:0005371 10.1 AHSG ANKH ENPP1 FBN1 FGF23 GALNT3
8 integument MP:0010771 10.09 ENPP1 FBN1 FGF23 GALNT3 KL LMNA
9 mortality/aging MP:0010768 10.07 ANKH ENPP1 FBN1 FGF23 KL LMNA
10 hearing/vestibular/ear MP:0005377 9.99 AHSG ANKH ENPP1 KL LMNA PHEX
11 muscle MP:0005369 9.97 AHSG ANKH ENPP1 FBN1 GALNT3 KL
12 renal/urinary system MP:0005367 9.91 ENPP1 FBN1 FGF23 GALNT3 KL LMNA
13 reproductive system MP:0005389 9.7 ANKH FBN1 FGF23 GALNT3 KL LMNA
14 respiratory system MP:0005388 9.5 ANKH FBN1 FGF23 KL LMNA MGP
15 skeleton MP:0005390 9.4 AHSG ANKH ENPP1 FBN1 FGF23 GALNT3

Drugs & Therapeutics for Calcinosis

Drugs for Calcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 367)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Warfarin Approved Phase 4 81-81-2 6691 54678486
2
Phytonadione Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84-80-0 4812 5284607
3
Rivaroxaban Approved Phase 4 366789-02-8
4 fluindione Approved, Investigational Phase 4 957-56-2
5
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
6
Alendronate Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 66376-36-1, 121268-17-5 2088
7
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6
8
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
9
Everolimus Approved Phase 4,Not Applicable 159351-69-6 6442177
10
Sirolimus Approved, Investigational Phase 4,Not Applicable 53123-88-9 46835353 6436030 5284616
11
Fluvastatin Approved Phase 4 93957-54-1 1548972
12
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 122320-73-4 77999
13
Sevelamer Approved Phase 4,Phase 3,Phase 2,Not Applicable 52757-95-6
14
Pravastatin Approved Phase 4 81093-37-0 54687
15
Ethanol Approved Phase 4,Phase 3,Not Applicable 64-17-5 702
16
Calcium acetate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 62-54-4
17
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
18
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
19
Clopidogrel Approved Phase 4,Phase 3 113665-84-2, 120202-66-6 60606
20
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
21
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
22
Testosterone enanthate Approved Phase 4 315-37-7 9416
23
Testosterone Approved, Investigational Phase 4 58-22-0 6013
24
Methyltestosterone Approved Phase 4 58-18-4 6010
25
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 137-58-6 3676
26
Denosumab Approved Phase 4,Phase 3,Phase 2 615258-40-7
27
Mycophenolic acid Approved Phase 4,Not Applicable 24280-93-1 446541
28
Apixaban Approved Phase 4 503612-47-3 10182969
29
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
30
Adenosine Approved, Investigational Phase 4 58-61-7 60961
31
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
32
Methylprednisolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 83-43-2 6741
33
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 1,Not Applicable 302-25-0
34
Prednisolone Approved, Vet_approved Phase 4,Phase 1,Not Applicable 50-24-8 5755
35
Methylprednisolone hemisuccinate Approved Phase 4,Phase 1,Not Applicable 2921-57-5
36
Simvastatin Approved Phase 4 79902-63-9 54454
37
Amlodipine Approved Phase 4 88150-42-9 2162
38
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
39
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
40
Chromium Approved Phase 4,Not Applicable 7440-47-3 27668
41
Phenprocoumon Approved, Investigational Phase 4 435-97-2 54680692 9908
42
Nicotinamide Approved, Investigational Phase 4,Phase 3,Phase 2 98-92-0 936
43
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
44
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
45
Ofloxacin Approved Phase 4 82419-36-1 4583
46
Abatacept Approved Phase 4,Not Applicable 332348-12-6 10237
47
Acarbose Approved, Investigational Phase 4 56180-94-0 441184
48
Tacrolimus Approved, Investigational Phase 4,Not Applicable 104987-11-3 445643 439492
49
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
50
Menadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-27-5 4055

Interventional clinical trials:

(show top 50) (show all 575)
# Name Status NCT ID Phase Drugs
1 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Unknown status NCT02610933 Phase 4 rivaroxaban
2 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
3 Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation Unknown status NCT02161965 Phase 4 Rivaroxaban;Fluindione;Warfarin
4 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
5 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
6 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
7 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4 Calcitriol;placebo
8 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
9 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
10 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
11 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
12 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
13 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
14 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
15 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
16 Adverse Plaque Characteristics in CCTA and TVC Imaging Unknown status NCT02350959 Phase 4 Atorvastatin;Atorvastatin
17 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
18 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4 Menaquinone
19 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
20 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
21 Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque Completed NCT02090075 Phase 4 apixaban;warfarin
22 Can Alendronate Suppress Calcification and Improve Bone Density in Chronic Peritoneal Dialysis Patients? Completed NCT00261625 Phase 4 alendronate
23 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
24 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4 calcium acetate;sevelamer;atorvastatin
25 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
26 Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients Completed NCT00745225 Phase 4 Pioglitazone;placebo comparator
27 The XLIMUS-DES in Very Complex Lesions Completed NCT02360020 Phase 4
28 Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY) Completed NCT00295191 Phase 4
29 Sevelamer, Fetuin-A and Endothelial Dysfunction in CKD Completed NCT00486772 Phase 4 Sevelamer (Renagel), calcium acetate (Phos-ex)
30 Sevelamer, FGF-23 and Endothelial Dysfunction in Chronic Kidney Disease (CKD) Completed NCT01135615 Phase 4 Sevelamer;calcium acetate
31 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4 Regadenoson myocardial perfusion imaging;Regadenoson MRI myocardial blood flow
32 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Completed NCT02376010 Phase 4 rivaroxaban;Warfarin
33 Effect of Atorvastatin on Bone-vascular Axis Completed NCT02342015 Phase 4 Atorvastatin
34 Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol Completed NCT01748396 Phase 4 Calcitriol;Calcium Carbonate
35 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Completed NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
36 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4 Statin (simvastatin)
37 REmoval of Free Light Chains. A COmpaRison of Three Different dialyzERs Completed NCT02950389 Phase 4
38 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4 Cinacalcet
39 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure Completed NCT00124969 Phase 4 Amlodipine;Placebo
40 PROMUS Element Plus US Post-Approval Study Completed NCT01589978 Phase 4 Aspirin;P2Y12 antagonist
41 Effect of Aged Garlic Extract on Atherosclerosis Completed NCT01534910 Phase 4 aged garlic extract;placebo
42 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
43 Rosuvastatin in the Long-term Treatment of Hypercholesterolaemic Subjects With Coronary Heart Disease Completed NCT00329160 Phase 4 Rosuvastatin;HMG CoA inhibitor
44 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4 cinacalcet;control
45 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
46 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
47 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4 Atorvastatin
48 Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation. Completed NCT01939977 Phase 4 Paricalcitol;Calcifediol
49 Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis Completed NCT00413803 Phase 4
50 Bundang Rehabilitative Impact Study of the Elbow Epicondylitis Completed NCT02492945 Phase 4 3ml-Rejuvinex;3ml-15%-dextrose solution

Search NIH Clinical Center for Calcinosis

Cochrane evidence based reviews: calcinosis

Genetic Tests for Calcinosis

Genetic tests related to Calcinosis:

# Genetic test Affiliating Genes
1 Calcinosis 29

Anatomical Context for Calcinosis

MalaCards organs/tissues related to Calcinosis:

41
Bone, Brain, Breast, Liver, Skin, Lung, Kidney

Publications for Calcinosis

Articles related to Calcinosis:

(show top 50) (show all 1098)
# Title Authors Year
1
C.B-17 SCID Mice Develop Epicardial Calcinosis with Unaltered Cardiac Function. ( 29959870 )
2018
2
Scrotal Calcinosis in Brothers. ( 29606827 )
2018
3
Tumoral Calcinosis: A Giant Tumoral Mass in the Shoulder Joint of a Dialysis Patient. ( 29876175 )
2018
4
Calcinosis cutis universalis in systemic sclerosis. ( 29451139 )
2018
5
Lethal Visceral Calcinosis in Fulminant Hypercalcemic Crisis. ( 29093412 )
2018
6
Asymmetric Calcinosis in an Adult Patient With Antisynthetase Syndrome. ( 29319552 )
2018
7
Dialysis as a Treatment Option for a Patient With Normal Kidney Function and Familial Tumoral Calcinosis Due to a Compound Heterozygous FGF23 Mutation. ( 29548779 )
2018
8
Idiopathic scrotal calcinosis - A case report. ( 29477103 )
2018
9
Calcinosis cutis: a rock and a hard place. ( 29897113 )
2018
10
MAPnckeberg medial calcinosis of the infraorbital arteries: a first case report. ( 29248421 )
2018
11
Calcinosis Cutis and Negative Pressure Wound Therapy as Adjuncts to Surgical Management: Case Report and Review of the Literature. ( 29584607 )
2018
12
Scrotal calcinosis in an adult patient with amyopathic dermatomyositis. ( 29945258 )
2018
13
Characterization of a Pseudoxanthoma elasticum-like patient with coagulation deficiency, cutaneous calcinosis and GGCX compound heterozygosity. ( 29175035 )
2018
14
Dermoscopic features of Milia-Like calcinosis cutis. ( 29512978 )
2018
15
Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis. ( 29622763 )
2018
16
Enzootic calcinosis in horses grazing Solanum glaucophyllum in Argentina. ( 29202673 )
2018
17
Dystrophic calcinosis cutis within burns, successfully treated with excision and secondary intention wound healing. ( 29430689 )
2018
18
Hyperphosphatemic familial tumoral calcinosis secondary to fibroblast growth factor 23 (FGF23) mutation: a report of two affected families and review of the literature. ( 29923062 )
2018
19
Multiple Scattered and Small Lesions of Lower Limbs: Idiopathic Calcinosis Cutis: A Case Report. ( 29725520 )
2018
20
Idiopathic Scrotal Calcinosis - A Case Report. ( 29484000 )
2018
21
Hyperphosphatemic tumoral calcinosis caused by FGF23 compound heterozygous mutations: what are the therapeutic options for a better control of phosphatemia? ( 29594503 )
2018
22
Dystrophic calcinosis cutis of the auricles after injury in Down's syndrome. ( 29756299 )
2018
23
Clinical Images: Calcinosis of the mandible in dermatomyositis. ( 29579373 )
2018
24
Added value of newer optical coherence tomography technologies in hyperphosphatemic familial tumoural calcinosis. ( 29426463 )
2018
25
Facial Calcinosis Cutis in a Woman with Paraneoplastic Dermatomyositis. ( 29598989 )
2018
26
Secondary Calcinosis of the Foot. ( 29292317 )
2018
27
Extensive calcinosis cutis in a patient with systemic lupus erythematosus: An exceptional complication. ( 29555168 )
2018
28
Calcinosis Cutis Caused by Subcutaneous Injection of Calcium-containing Heparin in a Patient with Systemic Lupus Erythematosus. ( 29881870 )
2018
29
Calcinosis Cutis: WOC Nurse Management. ( 29300294 )
2018
30
Dystrophic calcinosis in a patient with overlap syndrome (scleroderma and rheumatoid arthritis) treated by leflunomide: A case report. ( 30461645 )
2018
31
Subepidermal Calcinosis in the Ocular Adnexa: A Systematic Review. ( 28430707 )
2018
32
Systemic Calcinosis in NXP2-Dermatomyositis. ( 29319550 )
2018
33
Lacrimal punctal and peripunctal involvement in calcinosis cutis. ( 29676330 )
2018
34
Hyperphosphatemic Familial Tumoral Calcinosis in Two Siblings with a Novel Mutation in GALNT3 gene: Experience from Southern Turkey. ( 30015621 )
2018
35
Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor. ( 30021048 )
2018
36
Idiopathic scrotal calcinosis: report of 2 cases, and review of pathogenesis and factors that determine patients' acceptance of surgical treatment. ( 30022844 )
2018
37
Calcinosis and malignancy are rare in Chinese adult patients with myositis and nuclear matrix protein 2 antibodies identified by an unlabeled immunoprecipitation assay. ( 30039266 )
2018
38
Treatment With Rituximab in Juvenile Dermatomyositis: Effect on Calcinosis. ( 30054253 )
2018
39
Ultrasonographic Diagnosis of Tumoral Calcinosis in End-Stage Renal Disease. ( 30060796 )
2018
40
Febrile Calcinosis in Scleroderma. ( 30076824 )
2018
41
Epidermal Calcinosis: A New Pattern. ( 30124486 )
2018
42
Calcinosis in scleroderma. ( 30124603 )
2018
43
Successful Treatment of Tumoral Calcinosis by Lanthanum Carbonate: A Case Report. ( 30146573 )
2018
44
Intraspinal calcinosis mimicking intervertebral disc extrusion: A clinical and surgical case report. ( 30186667 )
2018
45
Milia-like idiopathic calcinosis cutis and plaque-type syringoma in a girl with Down syndrome. ( 30194873 )
2018
46
Autoimmune hyperphosphatemic tumoral calcinosis in a patient with FGF23 autoantibodies. ( 30226830 )
2018
47
Topical sodium thiosulfate for calcinosis cutis associated with autoimmune connective tissue diseases: the Mayo Clinic experience, 2012-2017. ( 30251264 )
2018
48
A Rare Cause of Leg Ulcer: Calcinosis Cutis as a Part of CREST Syndrome. ( 30270692 )
2018
49
131I uptake in tumoral calcinosis in a patient on hemodialysis treated for thyroid cancer. ( 30291041 )
2018
50
Extensive Calcinosis Cutis inOverlap Syndrome. ( 30360808 )
2018

Variations for Calcinosis

Expression for Calcinosis

Search GEO for disease gene expression data for Calcinosis.

Pathways for Calcinosis

Pathways related to Calcinosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 ENPP1 MGP SPP1

GO Terms for Calcinosis

Cellular components related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.62 AHSG FBN1 MGP SPARC
2 endoplasmic reticulum lumen GO:0005788 9.56 AHSG FBN1 FGF23 SPP1
3 extracellular space GO:0005615 9.56 AHSG CALCA ENPP1 FBN1 FGF23 KL
4 collagen-containing extracellular matrix GO:0062023 9.46 AHSG FBN1 MGP SPARC
5 extracellular region GO:0005576 9.28 AHSG CALCA ENPP1 FBN1 FGF23 KL

Biological processes related to Calcinosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.86 AHSG FBN1 FGF23 SPP1
2 regulation of signaling receptor activity GO:0010469 9.83 CALCA FBN1 FGF23 KL SPP1
3 ossification GO:0001503 9.71 AHSG MGP SPARC
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.69 FGF23 GALNT3 KL
5 skeletal system development GO:0001501 9.67 AHSG ANKH FBN1 PHEX
6 negative regulation of insulin receptor signaling pathway GO:0046627 9.59 AHSG ENPP1
7 negative regulation of osteoclast differentiation GO:0045671 9.58 CALCA FBN1
8 phosphate-containing compound metabolic process GO:0006796 9.58 ENPP1 FGF23
9 response to vitamin D GO:0033280 9.57 PHEX SPP1
10 negative regulation of bone mineralization GO:0030502 9.55 AHSG FGF23
11 cellular response to vitamin D GO:0071305 9.52 FGF23 PHEX
12 biomineral tissue development GO:0031214 9.5 ENPP1 PHEX SPP1
13 cellular response to parathyroid hormone stimulus GO:0071374 9.49 FGF23 PHEX
14 endosomal vesicle fusion GO:0034058 9.48 SAMD9 SAMD9L
15 cellular phosphate ion homeostasis GO:0030643 9.46 ENPP1 FGF23
16 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.4 FGF23 KL
17 cellular protein metabolic process GO:0044267 9.35 AHSG CALCA FBN1 FGF23 SPP1
18 inorganic diphosphate transport GO:0030505 9.26 ANKH ENPP1
19 response to sodium phosphate GO:1904383 9.16 FGF23 PHEX
20 regulation of bone mineralization GO:0030500 9.02 AHSG ANKH ENPP1 FGF23 MGP

Molecular functions related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 ENPP1 FBN1 GALNT3 MGP SPARC
2 extracellular matrix binding GO:0050840 9.32 SPARC SPP1
3 fibroblast growth factor receptor binding GO:0005104 9.26 FGF23 KL
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 FGF23 KL RGL2
5 hormone activity GO:0005179 8.8 CALCA FBN1 KL

Sources for Calcinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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