Aliases & Classifications for Calcinosis

MalaCards integrated aliases for Calcinosis:

Name: Calcinosis 12 29 55 44 15 73
Pathologically Calcified Structure 12
Pathologic Calcification 12

Classifications:



External Ids:

Disease Ontology 12 DOID:182
MeSH 44 D002114
NCIt 50 C3672
UMLS 73 C0006663

Summaries for Calcinosis

Disease Ontology : 12 A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue.

MalaCards based summary : Calcinosis, also known as pathologically calcified structure, is related to tumoral calcinosis, hyperphosphatemic, familial, 1 and tumoral calcinosis, normophosphatemic, familial. An important gene associated with Calcinosis is SAMD9 (Sterile Alpha Motif Domain Containing 9), and among its related pathways/superpathways is Endochondral Ossification. The drugs Dalteparin and fluindione have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and breast, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 76 Calcinosis is the formation of calcium deposits in any soft... more...

Related Diseases for Calcinosis

Diseases related to Calcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 tumoral calcinosis, hyperphosphatemic, familial, 1 34.8 FGF23 GALNT3 KL
2 tumoral calcinosis, normophosphatemic, familial 32.5 CALCA GALNT3 RGL2 SAMD9 SAMD9L
3 familial tumoral calcinosis 31.6 FGF23 GALNT3 KL PHEX RGL2 SAMD9
4 hypervitaminosis d 30.4 FGF23 GALNT3 KL
5 enthesopathy 30.0 FGF23 PHEX
6 hyperphosphatemia 29.8 FGF23 GALNT3 KL MGP PHEX
7 hyperparathyroidism 29.8 CALCA FGF23 PHEX
8 secondary hyperparathyroidism of renal origin 29.4 CALCA FGF23
9 hyperostosis 29.4 ANKH FGF23 GALNT3 KL
10 pseudoxanthoma elasticum 27.6 ANKH ENPP1 FBN1 MGP SPP1
11 osteoporosis 27.1 AHSG CALCA FGF23 KL MGP SPARC
12 tumoral calcinosis, hyperphosphatemic, familial, 2 12.1
13 tumoral calcinosis, hyperphosphatemic, familial, 3 12.1
14 crest syndrome 11.8
15 basal ganglia calcification, idiopathic, 1 11.6
16 basal ganglia calcification, idiopathic, childhood-onset 11.5
17 mandibuloacral dysplasia with type a lipodystrophy 11.4
18 dermatomyositis 11.4
19 scleroderma, familial progressive 11.3
20 poikiloderma with neutropenia 11.2
21 nephrocalcinosis 11.2
22 primary familial brain calcification 11.0
23 familial idiopathic basal ganglia calcification 11.0
24 reynolds syndrome 11.0
25 cole disease 11.0
26 diffuse idiopathic skeletal hyperostosis 10.8
27 tracheal calcification 10.8 FGF23 KL
28 opsismodysplasia 10.5 FGF23 PHEX
29 papillary cystadenocarcinoma 10.5 SPARC SPP1
30 oncogenic osteomalacia 10.4 FGF23 PHEX
31 prolapse of female genital organ 10.4 LMNA SPARC
32 hypercementosis 10.4 ENPP1 SPP1
33 childhood type dermatomyositis 10.4
34 secondary hypertrophic osteoarthropathy 10.4 CALCA GALNT3
35 hypophosphatemic rickets, autosomal dominant 10.3 FGF23 GALNT3 PHEX
36 hypophosphatemic rickets, x-linked dominant 10.3 FGF23 KL PHEX
37 autosomal recessive hypophosphatemic rickets 10.3 ENPP1 FGF23 PHEX
38 dental pulp calcification 10.2 FBN1 SPP1
39 hypophosphatemic rickets, x-linked recessive 10.2 ENPP1 FGF23 PHEX
40 osseous heteroplasia, progressive 10.2 ENPP1 SPARC
41 arteriosclerosis 10.2 KL MGP SPP1
42 hypophosphatemia 10.2 ENPP1 FGF23 PHEX
43 cervicitis 10.2
44 rickets 10.2 ENPP1 FGF23 PHEX
45 lupus erythematosus 10.2
46 tricuspid valve prolapse 10.1 FBN1 PHEX
47 systemic lupus erythematosus 10.1
48 bone giant cell tumor 10.1 CALCA SPP1
49 phosphorus metabolism disease 10.1 FGF23 GALNT3 KL PHEX
50 adult dermatomyositis 10.1

Graphical network of the top 20 diseases related to Calcinosis:



Diseases related to Calcinosis

Symptoms & Phenotypes for Calcinosis

MGI Mouse Phenotypes related to Calcinosis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 PHEX LMNA GALNT3 SPARC MGP SPP1
2 homeostasis/metabolism MP:0005376 10.27 PHEX SAMD9L LMNA SPARC SPP1 MGP
3 cardiovascular system MP:0005385 10.19 SPP1 KL LMNA GALNT3 MGP FBN1
4 hematopoietic system MP:0005397 10.18 SPP1 KL PHEX SAMD9L LMNA GALNT3
5 immune system MP:0005387 10.17 KL PHEX SAMD9L LMNA GALNT3 SPARC
6 craniofacial MP:0005382 10.13 PHEX LMNA GALNT3 SPARC SPP1 KL
7 integument MP:0010771 10.06 KL SAMD9L LMNA GALNT3 SPARC SPP1
8 limbs/digits/tail MP:0005371 10.02 PHEX LMNA SPARC KL FGF23 GALNT3
9 hearing/vestibular/ear MP:0005377 9.97 KL PHEX LMNA ANKH ENPP1 AHSG
10 muscle MP:0005369 9.97 LMNA SPP1 MGP KL ANKH ENPP1
11 renal/urinary system MP:0005367 9.91 PHEX LMNA SPP1 MGP KL FGF23
12 reproductive system MP:0005389 9.7 SPP1 KL LMNA GALNT3 FBN1 ANKH
13 respiratory system MP:0005388 9.5 SPP1 KL LMNA MGP FBN1 ANKH
14 skeleton MP:0005390 9.4 LMNA SPARC SPP1 MGP KL PHEX

Drugs & Therapeutics for Calcinosis

Drugs for Calcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 347)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
2 fluindione Approved, Investigational Phase 4 957-56-2
3
Rivaroxaban Approved Phase 4 366789-02-8
4
Warfarin Approved Phase 4 81-81-2 6691 54678486
5
Alendronate Approved Phase 4,Phase 2,Not Applicable 121268-17-5, 66376-36-1 2088
6
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
7
Zinc Approved, Investigational Phase 4,Phase 2 7440-66-6 23994
8
Everolimus Approved Phase 4,Not Applicable 159351-69-6 6442177
9
Sirolimus Approved, Investigational Phase 4,Not Applicable 53123-88-9 5284616 6436030 46835353
10
Fluvastatin Approved Phase 4 93957-54-1 1548972
11
Rosiglitazone Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 122320-73-4 77999
12
Sevelamer Approved Phase 4,Phase 3,Phase 2,Not Applicable 52757-95-6
13
Pravastatin Approved Phase 4 81093-37-0 54687
14
Ethanol Approved Phase 4,Phase 3 64-17-5 702
15
Calcium acetate Approved, Investigational Phase 4,Phase 3,Not Applicable 62-54-4
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
20
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 137-58-6 3676
21
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
22
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
23
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
24
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
25
Denosumab Approved Phase 4,Phase 3,Phase 2 615258-40-7
26
Mycophenolate mofetil Approved, Investigational Phase 4,Not Applicable 128794-94-5 5281078
27
Mycophenolic acid Approved Phase 4,Not Applicable 24280-93-1 446541
28
Apixaban Approved Phase 4 503612-47-3 10182969
29
Adenosine Approved, Investigational Phase 4 58-61-7 60961
30
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
31
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
32
Simvastatin Approved Phase 4 79902-63-9 54454
33
Amlodipine Approved Phase 4 88150-42-9 2162
34
Phenprocoumon Approved, Investigational Phase 4 435-97-2 9908 54680692
35
Salicylic acid Approved, Investigational, Vet_approved Phase 4 69-72-7 338
36
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
37
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
38
Ofloxacin Approved Phase 4 82419-36-1 4583
39
Abatacept Approved Phase 4,Not Applicable 332348-12-6 10237
40
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
42
Chromium Approved Phase 4 7440-47-3 27668
43
Miconazole Approved, Investigational, Vet_approved Phase 4,Not Applicable 22916-47-8 4189
44
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
45
Tacrolimus Approved, Investigational Phase 4,Not Applicable 104987-11-3 445643 439492
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
47
Menadione Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-27-5 4055
48
Phytonadione Approved, Investigational, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84-80-0 4812 5284607
49
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-16-2
50
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 67-97-0 6221 5280795

Interventional clinical trials:

(show top 50) (show all 526)
# Name Status NCT ID Phase Drugs
1 Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients Unknown status NCT01101698 Phase 4 Vitamin K2+10μg cholecalciferol;Vitamin D
2 Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation Unknown status NCT02161965 Phase 4 Rivaroxaban;Fluindione;Warfarin
3 Alendronate for Vascular Calcification in Peritoneal Dialysis Patients? Unknown status NCT00299572 Phase 4 alendronate (Fosamax)
4 The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus Unknown status NCT02418884 Phase 4 rosuvastatin
5 Treatment of Coronary Atherosclerosis by Insulin Sensitizers in Insulin-Resistant Patients Unknown status NCT00155350 Phase 4 pioglitazone
6 Effect of Vitamin D Supplement on Osteoprotegin Expression and Disease Progression in Patients With Chronic Kidney Disease Stage 1 and 2 Unknown status NCT01561222 Phase 4 Calcitriol;placebo
7 TRANSFORM OCT TRiple Assessment of Neointima Stent FOrmation to Reabsorbable polyMer With Optical Coherence Tomography Unknown status NCT01972022 Phase 4
8 A Study of Ferric Citrate to Improve Inflammation and Lipid Levels Unknown status NCT02661295 Phase 4 Ferric Citrate
9 Fluvastatin AmelIorates aTHerosclerosis Study Unknown status NCT01681199 Phase 4 Fluvastatin extended release tablet
10 Rosiglitazone Therapy In The Prevention Of Coronary Artery Disease In Patients With Impaired Glucose Tolerance Unknown status NCT00733174 Phase 4 Rosiglitazone;Placebo
11 How Bone is Made in Children Receiving Dialysis Unknown status NCT01799317 Phase 4 Vitamin D2
12 Effect of Short Term Atorvastatin Treatment,80mg/Day on Early Regression of Carotid Artery Atherosclerotic Lesions Unknown status NCT00640744 Phase 4 Atorvastatin
13 The Effects of AST-120 on Endothelial Dysfunction in Patients With Chronic Kidney Disease Unknown status NCT01157260 Phase 4 Kremezin
14 Adverse Plaque Characteristics in CCTA and TVC Imaging Unknown status NCT02350959 Phase 4 Atorvastatin;Atorvastatin
15 The Effects of Pravastatin and Rosuvastatin on Coronary Plaques in Patients With Stable Angina Pectoris Unknown status NCT01325818 Phase 4 pravastatin, rosuvastatin
16 Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? Completed NCT02876354 Phase 4 Menaquinone
17 Study of the Effect of Alendronate on Vascular Calcification and Arterial Stiffness in Chronic Kidney Disease Completed NCT00395382 Phase 4 Alendronate;Placebo
18 Vitamin D and Coronary Calcification Study Completed NCT00752102 Phase 4 Calcitriol (Rocaltrol®);Paricalcitol
19 Can Alendronate Suppress Calcification and Improve Bone Density in Chronic Peritoneal Dialysis Patients? Completed NCT00261625 Phase 4 alendronate
20 ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis Completed NCT00379899 Phase 4 cinacalcet
21 Apixaban Versus Warfarin in the Evaluation of Progression of Atherosclerotic Calcification and Vulnerable Plaque Completed NCT02090075 Phase 4 apixaban;warfarin
22 CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients Completed NCT00211939 Phase 4 calcium acetate;sevelamer;atorvastatin
23 Parathyroidectomy in Endstage Renal Disease Completed NCT00745719 Phase 4
24 Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients Completed NCT00745225 Phase 4 Pioglitazone;placebo comparator
25 The XLIMUS-DES in Very Complex Lesions Completed NCT02360020 Phase 4
26 Multiple Interventions Related to Dialysis Procedures in Order to Reduce Cardiovascular Morbidity and Mortality in HD Patients(EGESTUDY) Completed NCT00295191 Phase 4
27 Sevelamer, Fetuin-A and Endothelial Dysfunction in CKD Completed NCT00486772 Phase 4 Sevelamer (Renagel), calcium acetate (Phos-ex)
28 Sevelamer, FGF-23 and Endothelial Dysfunction in Chronic Kidney Disease (CKD) Completed NCT01135615 Phase 4 Sevelamer;calcium acetate
29 Regadenoson Blood Flow in Type 1 Diabetes (RABIT1D) Completed NCT01019486 Phase 4 Regadenoson myocardial perfusion imaging;Regadenoson MRI myocardial blood flow
30 Effect of Atorvastatin on Bone-vascular Axis Completed NCT02342015 Phase 4 Atorvastatin
31 Effect of Phosphate Binders on FGF-23 With Concurrent Calcitriol Completed NCT01748396 Phase 4 Calcitriol;Calcium Carbonate
32 Simvastatin Reduces Circulating Osteoprotegerin Levels in Patients With Type 2 Diabetes Completed NCT00471549 Phase 4 Statin (simvastatin)
33 REmoval of Free Light Chains. A COmpaRison of Three Different dialyzERs Completed NCT02950389 Phase 4
34 Cincalcet and Vascular Arterial Stiffness Among Peritoneal Dialysis Patients With Secondary Hyperparathyroidism Completed NCT01143987 Phase 4 Cinacalcet
35 Influence of Amlodipine on the Mortality of Patients With End-Stage Renal Failure Completed NCT00124969 Phase 4 Amlodipine;Placebo
36 Effect of Aged Garlic Extract on Atherosclerosis Completed NCT01534910 Phase 4 aged garlic extract;placebo
37 TRT on BPH Hypoganadal MetS Patients. Florence-PROTEST Completed NCT02366975 Phase 4 Testosterone gel 2%
38 Rosuvastatin in the Long-term Treatment of Hypercholesterolaemic Subjects With Coronary Heart Disease Completed NCT00329160 Phase 4 Rosuvastatin;HMG CoA inhibitor
39 Cinacalcet stUdy for Peritoneal Dialysis Patients In Double Arm on the Lowing Effect OF iPTH Level Completed NCT01101113 Phase 4 cinacalcet;control
40 Prospective Study of Efficacy of Intra-muscular Vitamin D3 in Tropical Calcific Pancreatitis Completed NCT00956839 Phase 4 Vitamin D3 (Cholecalciferol)
41 Testosterone Replacement in Older Men and Atherosclerosis Progression Completed NCT00287586 Phase 4 Testosterone Gel (Androgel);Placebo
42 Lupus Atherosclerosis Prevention Study Completed NCT00120887 Phase 4 Atorvastatin
43 Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation. Completed NCT01939977 Phase 4 Paricalcitol;Calcifediol
44 Comparison of Four and Eight Hours Dialysis Sessions in Thrice Weekly Hemodialysis Completed NCT00413803 Phase 4
45 Bundang Rehabilitative Impact Study of the Elbow Epicondylitis Completed NCT02492945 Phase 4 3ml-Rejuvinex;3ml-15%-dextrose solution
46 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Without VitK2 in Hemodialysis Patients Recruiting NCT02610933 Phase 4 rivaroxaban
47 Effect of Vitamin D3 Supplementation on Arterial and Bone Remodeling in Chronic Kidney Disease Patients Recruiting NCT02999204 Phase 4 Vitamin D3
48 Assessment of Osteoblastic Activity With 18F-Fluoride in Aortic Bioprosthesis Structural Valve Dysfunction (SVD) Recruiting NCT03015818 Phase 4
49 Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium Recruiting NCT02376010 Phase 4 rivaroxaban;Warfarin
50 Impact of Hepatitis C Therapy and Bone Health Recruiting NCT03221582 Phase 4 EBR/GZR

Search NIH Clinical Center for Calcinosis

Cochrane evidence based reviews: calcinosis

Genetic Tests for Calcinosis

Genetic tests related to Calcinosis:

# Genetic test Affiliating Genes
1 Calcinosis 29

Anatomical Context for Calcinosis

MalaCards organs/tissues related to Calcinosis:

41
Kidney, Bone, Breast, Heart, Endothelial, Spinal Cord, Testes

Publications for Calcinosis

Articles related to Calcinosis:

(show top 50) (show all 770)
# Title Authors Year
1
C.B-17 SCID Mice Develop Epicardial Calcinosis with Unaltered Cardiac Function. ( 29959870 )
2018
2
Scrotal Calcinosis in Brothers. ( 29606827 )
2018
3
Tumoral Calcinosis: A Giant Tumoral Mass in the Shoulder Joint of a Dialysis Patient. ( 29876175 )
2018
4
Calcinosis cutis universalis in systemic sclerosis. ( 29451139 )
2018
5
Lethal Visceral Calcinosis in Fulminant Hypercalcemic Crisis. ( 29093412 )
2018
6
Asymmetric Calcinosis in an Adult Patient With Antisynthetase Syndrome. ( 29319552 )
2018
7
Dialysis as a Treatment Option for a Patient With Normal Kidney Function and Familial Tumoral Calcinosis Due to a Compound Heterozygous FGF23 Mutation. ( 29548779 )
2018
8
Idiopathic scrotal calcinosis - A case report. ( 29477103 )
2018
9
Calcinosis cutis: a rock and a hard place. ( 29897113 )
2018
10
MAPnckeberg medial calcinosis of the infraorbital arteries: a first case report. ( 29248421 )
2018
11
Calcinosis Cutis and Negative Pressure Wound Therapy as Adjuncts to Surgical Management: Case Report and Review of the Literature. ( 29584607 )
2018
12
Scrotal calcinosis in an adult patient with amyopathic dermatomyositis. ( 29945258 )
2018
13
Characterization of a Pseudoxanthoma elasticum-like patient with coagulation deficiency, cutaneous calcinosis and GGCX compound heterozygosity. ( 29175035 )
2018
14
Dermoscopic features of Milia-Like calcinosis cutis. ( 29512978 )
2018
15
Esophageal Mucosal Calcinosis: A Rare Site of Gastrointestinal Mucosal Calcinosis. ( 29622763 )
2018
16
Enzootic calcinosis in horses grazing Solanum glaucophyllum in Argentina. ( 29202673 )
2018
17
Dystrophic calcinosis cutis within burns, successfully treated with excision and secondary intention wound healing. ( 29430689 )
2018
18
Hyperphosphatemic familial tumoral calcinosis secondary to fibroblast growth factor 23 (FGF23) mutation: a report of two affected families and review of the literature. ( 29923062 )
2018
19
Multiple Scattered and Small Lesions of Lower Limbs: Idiopathic Calcinosis Cutis: A Case Report. ( 29725520 )
2018
20
Idiopathic Scrotal Calcinosis - A Case Report. ( 29484000 )
2018
21
Hyperphosphatemic tumoral calcinosis caused by FGF23 compound heterozygous mutations: what are the therapeutic options for a better control of phosphatemia? ( 29594503 )
2018
22
Dystrophic calcinosis cutis of the auricles after injury in Down's syndrome. ( 29756299 )
2018
23
Clinical Images: Calcinosis of the mandible in dermatomyositis. ( 29579373 )
2018
24
Added value of newer optical coherence tomography technologies in hyperphosphatemic familial tumoural calcinosis. ( 29426463 )
2018
25
Facial Calcinosis Cutis in a Woman with Paraneoplastic Dermatomyositis. ( 29598989 )
2018
26
Secondary Calcinosis of the Foot. ( 29292317 )
2018
27
Extensive calcinosis cutis in a patient with systemic lupus erythematosus: An exceptional complication. ( 29555168 )
2018
28
Calcinosis Cutis Caused by Subcutaneous Injection of Calcium-containing Heparin in a Patient with Systemic Lupus Erythematosus. ( 29881870 )
2018
29
Calcinosis Cutis: WOC Nurse Management. ( 29300294 )
2018
30
Lacrimal punctal and peripunctal involvement in calcinosis cutis. ( 29676330 )
2018
31
Systemic Calcinosis in NXP2-Dermatomyositis. ( 29319550 )
2018
32
Idiopathic Tumoral Calcinosis - Rare Clinico Pathological Entity: A Report of Two Cases. ( 28764177 )
2017
33
Facial calcinosis cutis in a patient with systemic lupus erythematosus: A case report of tissue injury owing to photosensitivity as the cause of dystrophic calcification. ( 28936472 )
2017
34
Big Gain; No Pain: Tumoral Calcinosis. ( 28923522 )
2017
35
Extensive Dystrophic Calcinosis Cutis: A Severe Complication of Polymyositis/Systemic Sclerosis Overlap Syndrome. ( 28926465 )
2017
36
Quartz Crystal Microbalance Assay of Clinical Calcinosis Samples and Their Synthetic Models Differentiates the Efficacy of Chelation-Based Treatments. ( 28752990 )
2017
37
Calcinosis Cutis ( 28846311 )
2017
38
Severe Calcinosis in Limited Cutaneous Systemic Sclerosis. ( 28824081 )
2017
39
The idiopathic localized tumoral calcinosis: the "chicken wire" radiographic pattern. ( 28828127 )
2017
40
Efficacy of intralesional sodium thiosulfate injections for disabling tumoral calcinosis: Two cases. ( 28779847 )
2017
41
Clinical and radiological improvement in idiopathic calcinosis cutis with topical 25% sodium metabisulfite. ( 29076152 )
2017
42
Lack of Response to Intravenous Sodium Thiosulfate in Three Cases of Extensive Connective Tissue Disease-Associated Calcinosis Cutis. ( 28667747 )
2017
43
Mammography Findings of Breast Calcinosis in a Patient With Dermatomyositis. ( 28816763 )
2017
44
Metastatic calcinosis cutis in end-stage renal disease. ( 28670091 )
2017
45
Extraosseous Calcification of the Esophagus: Clinicopathologic Correlates of Esophageal Mucosal Calcinosis. ( 28932755 )
2017
46
Cutaneous calcinosis in a patient with limited scleroderma: CREST Syndrome. ( 29308290 )
2017
47
Scrotal calcinosis: two case reports. ( 29101926 )
2017
48
Calcified Keratoacanthoma with Tumoral Calcinosis in a 10-year-old Boy: A mere Co-incidence? ( 29263542 )
2017
49
Bilateral striopallidodentate calcinosis associated with SjAPgren's syndrome and IgDI> monoclonal gammopathy of undetermined significance. ( 29183861 )
2017
50
Idiopathic Calcinosis Cutis Universalis Treated Successfully with Oral Diltiazem-A Case Report. ( 28771811 )
2017

Variations for Calcinosis

Expression for Calcinosis

Search GEO for disease gene expression data for Calcinosis.

Pathways for Calcinosis

Pathways related to Calcinosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 ENPP1 MGP SPP1

GO Terms for Calcinosis

Cellular components related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 AHSG CALCA ENPP1 FBN1 FGF23 KL
2 endoplasmic reticulum lumen GO:0005788 9.46 AHSG FBN1 FGF23 SPP1
3 extracellular region GO:0005576 9.28 AHSG CALCA ENPP1 FBN1 FGF23 KL

Biological processes related to Calcinosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.86 AHSG FBN1 FGF23 SPP1
2 regulation of signaling receptor activity GO:0010469 9.83 CALCA FBN1 FGF23 KL SPP1
3 ossification GO:0001503 9.71 AHSG MGP SPARC
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.69 FGF23 GALNT3 KL
5 skeletal system development GO:0001501 9.67 AHSG ANKH FBN1 PHEX
6 negative regulation of insulin receptor signaling pathway GO:0046627 9.59 AHSG ENPP1
7 negative regulation of osteoclast differentiation GO:0045671 9.58 CALCA FBN1
8 phosphate-containing compound metabolic process GO:0006796 9.58 ENPP1 FGF23
9 response to vitamin D GO:0033280 9.57 PHEX SPP1
10 negative regulation of bone mineralization GO:0030502 9.55 AHSG FGF23
11 cellular response to vitamin D GO:0071305 9.52 FGF23 PHEX
12 endosomal vesicle fusion GO:0034058 9.49 SAMD9 SAMD9L
13 cellular response to parathyroid hormone stimulus GO:0071374 9.48 FGF23 PHEX
14 cellular phosphate ion homeostasis GO:0030643 9.46 ENPP1 FGF23
15 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 9.4 FGF23 KL
16 cellular protein metabolic process GO:0044267 9.35 AHSG CALCA FBN1 FGF23 SPP1
17 biomineral tissue development GO:0031214 9.33 ENPP1 PHEX SPP1
18 inorganic diphosphate transport GO:0030505 9.32 ANKH ENPP1
19 response to sodium phosphate GO:1904383 9.26 FGF23 PHEX
20 regulation of bone mineralization GO:0030500 9.02 AHSG ANKH ENPP1 FGF23 MGP

Molecular functions related to Calcinosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 ENPP1 FBN1 GALNT3 MGP SPARC
2 extracellular matrix binding GO:0050840 9.32 SPARC SPP1
3 fibroblast growth factor receptor binding GO:0005104 9.26 FGF23 KL
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.13 FGF23 KL RGL2
5 hormone activity GO:0005179 8.8 CALCA FBN1 KL

Sources for Calcinosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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