Calciphylaxis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

GARD: ¹⁹ Calciphylaxis is a disease in which blood vessels (veins and arteries) become blocked by a build-up of calcium in the walls of the vessels, preventing blood from flowing to the skin or internal organs. The lack of blood flow (ischemia) damages healthy tissue and may causes the tissue to die (necrosis). The most obvious and frequent symptom of Calciphylaxis is damage to the skin, as ulcers can develop and become infected easily. Calciphylaxis can also affect fat tissue, internal organs, and skeletal muscle, causing infections, pain, and organ failure. The exact cause of Calciphylaxis is unknown.

MalaCards based summary: Calciphylaxis, also known as idiopathic calciphylaxis, is related to hyperparathyroidism and secondary hyperparathyroidism. An important gene associated with Calciphylaxis is FGF23 (Fibroblast Growth Factor 23), and among its related pathways/superpathways are Vitamin D receptor pathway and Ca, cAMP and Lipid Signaling. The drugs Magnesium citrate and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and skeletal muscle, and related phenotypes are skin ulcer and cellulitis

Orphanet: ⁵⁸ A rare vascular calcification disorder typically characterized by occlusion of microvessels in the cutaneous tissue resulting in painful cutaneous lesions. The disorder is often life-limiting.

Wikipedia: ⁷⁵ Calciphylaxis, also known as calcific uremic arteriolopathy (CUA) or “Grey Scale”, is a rare syndrome... more...

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Related Diseases for Calciphylaxis

Diseases related to Calciphylaxis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)

#	Related Disease	Score	Top Affiliating Genes
1	hyperparathyroidism	30.7	VDR PTH FGF23 EPO CASR ALB
2	secondary hyperparathyroidism	30.5	VDR PTH FGF23 EPO CASR ALB
3	necrotizing fasciitis	30.2	FN1 ALB
4	primary hyperparathyroidism	30.2	VDR PTH FGF23 CASR ALB
5	calcinosis	30.2	MGP FGF23 AHSG
6	arteriolosclerosis	30.2	CD79A ALB
7	parathyroid adenoma	30.0	VDR PTH CASR ALB
8	decubitus ulcer	30.0	FN1 ALB
9	vascular disease	30.0	MGP FN1 CD40LG ALB
10	pseudoxanthoma elasticum	30.0	NT5E MGP GGCX
11	graves disease 1	30.0	PTH ALB
12	rickets	30.0	VDR PTH FGF23 CASR ALB
13	nutritional deficiency disease	29.9	MGP EPO ALB
14	osteitis fibrosa	29.9	PTH FGF23 CASR
15	hyperphosphatemia	29.8	VDR PTH MGP FGF23 CASR ALB
16	connective tissue disease	29.8	PTH FN1 FGF23 CD40LG ALB
17	hypoparathyroidism	29.8	VDR PTH FGF23 CASR
18	glomerulonephritis	29.8	FN1 CD79A CD40LG ALB
19	urolithiasis	29.8	VDR GGCX CASR ALB
20	vitamin k deficiency bleeding	29.8	PTH MGP GGCX AHSG
21	myocarditis	29.7	FN1 CD40LG ALB
22	myeloma, multiple	29.7	FN1 EPO CD79A CD40LG
23	nephrotic syndrome	29.7	FN1 EPO CD79A ALB
24	iga glomerulonephritis	29.7	FN1 CD79A CD40LG ALB
25	congestive heart failure	29.6	FN1 EPO ALB
26	hypophosphatemia	29.6	VDR PTH FGF23 ALB
27	renal osteodystrophy	29.6	VDR PTH FGF23 CASR
28	hypersensitivity vasculitis	29.5	CD79A ALB
29	cryoglobulinemia	29.5	FN1 CD79A CD40LG
30	autoimmune disease	29.5	VDR FN1 CD79A CD40LG
31	bone disease	29.4	VDR PTH FGF23 EPO CD40LG CASR
32	spondyloarthropathy 1	29.4	PTH CD79A CD40LG
33	acquired immunodeficiency syndrome	29.4	EPO CD79A CD40LG ALB
34	skin disease	29.3	VDR FN1 CD79A CD40LG ALB
35	hypocalcemia, autosomal dominant 1	29.2	VDR PTH FGF23 CASR ALB
36	immune deficiency disease	29.2	VDR NT5E FN1 CD79A CD40LG
37	polycystic kidney disease	29.2	PTH FN1 FGF23 EPO ALB
38	chronic kidney disease	29.1	VDR PTH MGP FGF23 EPO CD79A
39	lipoprotein quantitative trait locus	29.0	PTH FN1 FGF23 CD40LG ALB
40	parathyroid gland disease	29.0	VDR PTH MGP FGF23 EPO CASR
41	nephrolithiasis	28.7	VDR PTH FN1 FGF23 CASR AHSG
42	kidney disease	28.6	VDR PTH MGP FGF23 EPO CD79A
43	uremia	28.6	VDR PTH MGP FGF23 EPO CASR
44	arterial calcification of infancy	28.5	NT5E MGP GGCX FGF23 AHSG
45	diabetes mellitus	28.3	VDR PTH FGF23 EPO CD40LG CASR
46	mineral metabolism disease	27.9	VDR PTH MGP FGF23 EPO CASR
47	osteoporosis	27.2	VDR PTH MGP GGCX FGF23 EPO
48	calciphylaxis cutis	11.3
49	visceral calciphylaxis	11.0
50	end stage renal disease	10.9

Graphical network of the top 20 diseases related to Calciphylaxis:

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Symptoms & Phenotypes for Calciphylaxis

Human phenotypes related to Calciphylaxis:

⁵⁸ ³⁰ (show all 12)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	skin ulcer ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0200042
2	cellulitis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100658
3	sepsis ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100806
4	cutis marmorata ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000965
5	gangrene ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0100758
6	stage 5 chronic kidney disease ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003774
7	hyperphosphatemia ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0002905
8	abnormality of skin physiology ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0011122
9	secondary hyperparathyroidism ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0000867
10	arterial calcification ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0003207
11	ectopic ossification ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0011986
12	abnormality of metabolism/homeostasis ⁵⁸		Very frequent (99-80%)

MGI Mouse Phenotypes related to Calciphylaxis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.25	AHSG ALB CASR CD40LG CD79A EPO
2	cellular	MP:0005384	10.1	ALB CASR CD40LG CD79A EPO FN1
3	renal/urinary system	MP:0005367	10.08	ALB CASR CD40LG CD79A FGF23 MGP
4	cardiovascular system	MP:0005385	10.07	ALB CD40LG EPO FGF23 FN1 GGCX
5	muscle	MP:0005369	10	AHSG ALB CASR EPO FN1 MGP
6	immune system	MP:0005387	9.97	ALB CASR CD40LG CD79A EPO FGF23
7	skeleton	MP:0005390	9.91	AHSG CASR CD40LG FGF23 FN1 GGCX
8	hematopoietic system	MP:0005397	9.85	CASR CD40LG CD79A EPO FGF23 FN1
9	mortality/aging	MP:0010768	9.7	ALB CASR CD40LG CD79A EPO FGF23
10	integument	MP:0010771	9.17	CASR CD40LG FGF23 FN1 GGCX NT5E

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Drugs & Therapeutics for Calciphylaxis

Drugs for Calciphylaxis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Magnesium citrate

Approved

Phase 3

3344-18-1

2

Phylloquinone

Approved, Investigational

Phase 3

84-80-0

5284607

3

Sodium citrate

Approved, Investigational

Phase 3

68-04-2

23431961

4

Menadione

Approved, Nutraceutical

Phase 3

58-27-5

4055

5

Citric acid

Approved, Nutraceutical, Vet_approved

Phase 3

77-92-9

311

6

Menaquinone

Investigational

Phase 3

1182-68-9

7

Cathartics

Phase 3

8

Vitamins

Phase 3

9

Vitamin K 1

Phase 3

10

Vitamin K

Phase 3

11

Laxatives

Phase 3

12

Trace Elements

Phase 3

13

Antifibrinolytic Agents

Phase 3

14

Anticoagulants

Phase 3

15

Hemostatics

Phase 3

16

Gastrointestinal Agents

Phase 3

17

Naphthoquinone

Phase 3

18

Micronutrients

Phase 3

19

Coagulants

Phase 3

20

Citrate

Phase 3

21

Calcium, Dietary

Phase 3

22

Sodium thiosulfate

Phase 3

23

Anti-Bacterial Agents

Phase 3

24

Anti-Infective Agents

Phase 3

25

Antidotes

Phase 3

26

Antitubercular Agents

Phase 3

27

Antioxidants

Phase 3

28

Protective Agents

Phase 3

29

Chelating Agents

Phase 3

30

Pharmaceutical Solutions

Phase 3

31

Calcium

Nutraceutical

Phase 3

7440-70-2

271

32

Warfarin

Approved

81-81-2, 129-06-6

54678486

Synonyms:

(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarin

(Phenyl-1 acetyl-2 ethyl) 3-hydroxy-4 coumarine

(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2-benzopyrone

1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone

200 Coumarin

3-(1'-Phenyl-2'-acetylethyl)-4-hydroxycoumarin

3-(Acetonylbenzyl)-4-hydroxycoumarin

3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin

3-(alpha-Phenyl-beta-acetylaethyl)-4-hydroxycumarin

3-(alpha-Phenyl-beta-acetylethyl)-4-hydroxycoumarin

4-Hydroxy-3- (3-oxo-1-fenyl-butyl) cumarine

4-Hydroxy-3- (3-oxo-1-phenyl-butyl)-cumarin

4-Hydroxy-3-(3-oxo-1-fenyl-butyl) cumarine

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one

4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one

4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin

4-Hydroxy-3-(3-oxo-1-phenyl-butyl)-cumarin

4-Idrossi-3- (3-oxo-)-fenil-butil)-cumarine

4-Idrossi-3-(3-oxo-)-fenil-butil)-cumarine

4-Idrossi-3-(3-oxo-1-fenil-butil)-cumarine

4oh-Coumarin deriv.

aldo Brand OF warfarin sodium

Aldocumar

Antigen brand OF warfarin sodium

Apotex brand OF warfarin sodium

apo-Warfarin

Arab rat death

Arab rat deth

Athrombin

Athrombine-K

Athrombin-K

Bailly brand OF warfarin sodium

Boots brand OF warfarin sodium

Bristol-myers squibb brand OF warfarin sodium

Brumolin

Choice

Compound 42

CO-Rax

Coumadin

Coumadin Tabs

Coumadin®|Marevan®|panwarfin

Coumadine

Coumafen

Coumafene

Coumaphen

Coumaphene

Coumarins

Coumefene

Cov-R-tox

D-CON

delta-CON

Dethmor

Dethnel

Dicusat e

DL-3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin

Eastern states duocide

Estedi brand OF warfarin sodium

fasco Fascrat powder

Frass-ratron

Genpharm brand OF warfarin sodium

Gen-warfarin

Goldshield brand OF warfarin sodium

Jantoven

Killgerm sewarin P

Kumader

Kumadu

Kumatox

Kypfarin

Latka 42

Liqua-tox

Maag rattentod cum

Marevan

Mar-frin

Martin'S mar-frin

Maveran

Mouse pak

NSC-59813

PANWARFIN

Place-pax

Potassium, warfarin

Prothromadin

Rat & mice bait

Rat and mice bait

Rat-alpha-way

Rat-a-way

Rat-beta-gon

Rat-b-gon

Rat-gard

Rat-kill

Rat-mix

Rat-O-cide #2

Rat-O-cide no. 2

Rat-ola

Ratorex

Ratox

Ratoxin

Ratron

Ratron g

Rats-NO-more

Ratten-koederrohr

Rattenstreupulver neu schacht

Rattenstreupulver new schacht

Rattentraenke

Rat-trol

Rattunal

RAX

RCR Grey squirrel killer concentrate

Rodafarin

Rodafarin c

ro-Deth

Rodex

Rodex blox

Rosex

Rough & ready mouse mix

Rough and ready mouse mix

Sakarat

Sewarin

Sodium, warfarin

Sofarin

Solfarin

Sorexa plus

Spray-trol brand roden-trol

Tedicumar

Temus W

Tintorane

Tox-hid

Twin light rat away

Vampirinip II

Vampirinip III

Waran

Warf 42

Warfant

Warfarat

WARFARIN

Warfarin Plus

Warfarin potassium

Warfarin Q

Warfarin sodium

Warfarina

Warfarine

Warficide

Warfilone

Zoocoumarin

Interventional clinical trials:

(show all 16)

#	Name	Status	NCT ID	Phase	Drugs
1	Better Evidence and Translation for Calciphylaxis	Recruiting	NCT05018221	Phase 3	Vitamin K1;Magnesium citrate;Sodium Thiosulfate;Placebo injection (normal saline);Placebo capsule (Vitamin K1);Placebo tablet (Magnesium citrate)
2	A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of SNF472 When Added to Background Care for the Treatment of Calciphylaxis	Active, not recruiting	NCT04195906	Phase 3	Experimental: SNF472;Placebo Comparator: Placebo;Experimatenl SNF472 (Open-label)
3	A Phase 3, Intravenous Sodium Thiosulfate for Acute Calciphylaxis Treatment: A Multicenter, Randomized, Double-blind, Placebo-controlled, Clinical Trial	Terminated	NCT03150420	Phase 3	Sodium Thiosulfate;Placebo-Normal Saline
4	Randomized Double Blind Placebo Controlled Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopathy Followed by a Single Armed Extension Phase to Prospectively Observe Lesion Progression in the Presence of Sodium Thiosulfate Treatment	Terminated	NCT02527213	Phase 3	Sodium thiosulfate;Placebo
5	Phase 2 Open Label Single Arm Repeat Dose Study to Assess the Effect of SNF472 on Wound Healing in Uraemic Calciphylaxis Patients	Completed	NCT02790073	Phase 2	SNF472
6	Evaluation of Efficacy of Lanthanum Carbonate (Fosrenol) in Patients With Calciphylaxis	Completed	NCT01289626	Phase 1	lanthanum carbonate;Lanthanum for calciphylaxis
7	European Calciphylaxis Registry Network	Unknown status	NCT02635373
8	National Follow-up of Dialysis Patients With Sodium Thiosufate-treated Calciphylaxis Under Temporary Use Authorization	Unknown status	NCT03146793		Sodium Thiosulfate
9	Pathophysiology of Martorell Hypertensive Ischemic Leg Ulcer (HYTILU): A Comparison of Martorell HYTILU, Calciphylaxis and Venous Ulcer (Control)	Completed	NCT01578382
10	Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome : a Multicentric, Retrospective Cohort	Completed	NCT02854046
11	Evaluation of Vitamin K Supplementation for Calcific Uremic Arteriolopathy	Completed	NCT02278692
12	Partners Calciphylaxis Biobank and Patient Registry	Recruiting	NCT03032835
13	Effects of Human Amniotic Mesenchymal Stem Cells (hAMSCs) on Wound Healing in Uremic Calciphylaxis Patients: an Open Label Single Arm Study	Active, not recruiting	NCT04592640
14	Efficacy of Rheopheresis as Adjuvant Treatment of Calciphylaxis in Hemodialysis Patients : a Prospective Randomized Controled Single-blind Trial	Not yet recruiting	NCT04654000
15	Retrospective Study Evaluating the Contribution of Rheopheresis in the Treatment of Uremic Calciphylaxis	Not yet recruiting	NCT05633121
16	Observational Follow-up to ST-001 Calciphylaxis Pain Treatment With Intravenous Sodium Thiosulfate	Terminated	NCT03319914

Search NIH Clinical Center for Calciphylaxis

Cochrane evidence based reviews: calciphylaxis

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Genetic Tests for Calciphylaxis

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Anatomical Context for Calciphylaxis

Organs/tissues related to Calciphylaxis:

MalaCards : Skin, Kidney, Skeletal Muscle, Bone, Breast, Liver, Heart

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Publications for Calciphylaxis

Articles related to Calciphylaxis:

(show top 50) (show all 1459)

#	Title	Authors	PMID	Year
1	Erythema nodosum with incidental calciphylaxis secondary to zoledronic acid and denosumab. ⁶²	Perez Haded I...Rolon Cadena MC	36184744	2022
2	Mechanistic insights into CKD-MBD-related vascular calcification and its clinical implications. ⁶²	Kaur R...Singh R	36336124	2022
3	Non-uremic calciphylaxis: case series. ⁶²	Marti Pelluch CC...Vila Vall-Llovera M	36473774	2022
4	Complete resolution of calciphylaxis in a renal transplant patient with Calcifediol. ⁶²	Doraiswamy M...Meng S	34001663	2022
5	Use of the optimized sodium thiosulfate regimen for the treatment of calciphylaxis in Chinese patients. ⁶²	Yang X...Liu B	35634730	2022
6	Calciphylaxis in an adolescent without renal failure. ⁶²	Safavi M...Hosseinlou S	35840314	2022
7	Challenges management in penile calciphylaxis. ⁶²	Swatesutipun V...Benyakorn T	36131716	2022
8	Calciphylaxis arising following bariatric surgery: A case series. ⁶²	Cucka B...Kroshinsky D	36090194	2022
9	Identifying subcutaneous tissue microcalcification by Fluo-3 AM imaging in cutaneous calciphylaxis. ⁶²	Zhu X...Zhang X	35441735	2022
10	An Intensive Multidisciplinary Approach in Management of Extensive Nonuremic Calciphylaxis of the Bilateral Lower Extremities with Angioinvasive Fungus and Mold. ⁶²	Roberson JL...Yelon JA	36269818	2022
11	Calciphylaxis and its co-occurrence with connective tissue diseases. ⁶²	Zhou Y...Xie Q	36274216	2022
12	Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma. ⁶²	Nyembo PF...Shroff GR	36406917	2022
13	Penile calciphylaxis in patients with end-stage kidney disease undergoing dialysis: Invasive treatment and pain management. ⁶²	Kawai Y...Kawanishi H	34984854	2022
14	Chronic skin ulcer in a maintenance hemodialysis patient: pyoderma gangrenosum or calciphylaxis? ⁶²	Huang Y...Ou S	35349003	2022
15	Ulcer in a dialysis patient: Calciphylaxis or something simpler. ⁶²	Mohamed A...Thabet S	36172333	2022
16	The Role of Iron in Calciphylaxis-A Current Review. ⁶²	Wickens O...Sinha S	36233647	2022
17	Xeroradiography as a Noninvasive Tool in Diagnosing Calciphylaxis. ⁶²	Idris KM...Laing ME	35793077	2022
18	Manifestation of Nonuremic Calciphylaxis in the Extremities: Case Report and Review. ⁶²	Zulauf EE...Hardy MA	34876341	2022
19	Refractory wounds induced by normal-renal calciphylaxis: An under-recognised calcific arteriolopathy. ⁶²	Wu J...Ran X	36068658	2022
20	Suggestions for a New Clinical Classification Approach to Panniculitis Based on a Mayo Clinic Experience of 207 Cases. ⁶²	Anand NC...Alavi A	35849324	2022
21	Clinical characteristics and comorbidities of the most common atypical wounds in Northern Finland in 1996-2019: A retrospective registry study. ⁶²	Virkkala J...Sinikumpu SP	36189416	2022
22	Painless Scrotal Ulcers Become Something Unexpected: A Rare Case of Scrotal Calciphylaxis. ⁶²	Issar R...Wang Y	36237806	2022
23	Are Opioids Contraindicated for the Palliative Care Patient with Hypotension? ⁶²	Fukui N...Wordingham SE	35196131	2022
24	Cutaneous vascular calcification. Perieccrine calcification as a diagnostic key for calciphylaxis. ⁶²	Reolid A...Dauden E	35357702	2022
25	Calciphylaxis and Kidney Disease: A Review. ⁶²	Gallo Marin B...Robinson-Bostom L	35970430	2022
26	Role of myoinositol hexaphosphate (SNF 472) in calciphylaxis: an update. ⁶²	Ibrahim A...Khan MZ	35192233	2022
27	Characterization of Risk Factors for Calciphylaxis in Hemodialysis Patients in the Fraser Health Renal Program - A Matched Case-Control Retrospective Review. ⁶²	Jang A...Yan L	36036088	2022
28	Multicentric Study on High-Frequency Ultrasound Characterization of Calcium Deposits in Dermal and Subcutaneous Calciphylaxis and Calcinosis. ⁶²	Gamissans M...Wortsman X	34755910	2022
29	A Rare Presentation of Penile Calciphylaxis Requiring Partial Penectomy. ⁶²	Alshoubi A...Matougelwerfelli A	36158391	2022
30	Local, non-systemic, and minimally invasive therapies for calcinosis cutis: a systematic review. ⁶²	Nowaczyk J...Fiedor P	34165603	2022
31	[Multidisciplinary regenerative treatment and mechanisms for rescuing a severe calciphylaxis patient with human amnion-derived mesenchymal stem cells]. ⁶²	Wang NN...Liu JY	35872588	2022
32	Rituximab Used for the Treatment of Nonuremic Calciphylaxis: A Complication of Prolonged Steroid Use in Lupus Nephritis. ⁶²	Kahn C...Omman R	35795578	2022
33	Calciphylaxis in End-Stage Renal Disease: A Rare Condition With High Mortality. ⁶²	Bachu R...Hemmings S	35967146	2022
34	Retinal artery and vein occlusion in calciphylaxis. ⁶²	Naranjo A...Mahajan VB	35372715	2022
35	Nonuremic calciphylaxis manifesting with diffuse dermal angiomatosis. ⁶²	Castillo FT...Haemel AK	35518276	2022
36	A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism. ⁶²	Qin L...Wang N	35142858	2022
37	[Uremic calciphylaxis]. ⁶²	Lionet A...Urena Torres PA	35514006	2022
38	Calciphylaxis: utility of skin biopsy within a diagnostic algorithm. ⁶²	Kwapnoski Z...Brassard A	36259809	2022
39	[Left atrial appendage occlusion as replacement of coumarin anticoagulants in calciphylaxis]. ⁶²	Andolfatto M...Cozzolino M	35819038	2022
40	Calciphylaxis: Part I. Diagnosis and pathology. ⁶²	Rick J...Ortega-Loayza AG	35114300	2022
41	Management of chronic urinary retention in glanular penile calciphylaxis. ⁶²	Rahman S...Moore K	35530543	2022
42	Comments on "Ultrasound findings of calciphylaxis". ⁶²	Yang C...Zhao Y	35461600	2022
43	Images - Penile pain in the setting of end-stage renal disease: An unusual anatomic location for calciphylaxis. ⁶²	Nisar US...Sturgis CD	34941493	2022
44	Penectomy to manage penile gangrene caused by calciphylaxis, a case report. ⁶²	Bashar Abdulrahman M...Tareq Alnaib Z	35530551	2022
45	Understanding the zebras of wound care: an overview of atypical wounds. ⁶²	Ansert E...Gorelik S	35839157	2022
46	Synergy of sodium thiosulphate treatment and expanded hemodialysis in the management of calciphylaxis? A case report. ⁶²	Valga F...Rodriguez-Perez JC	36153291	2022
47	Calciphylaxis: Treatment and outlook-CME part II. ⁶²	Rick J...Ortega-Loayza AG	35202773	2022
48	The Relevance of Skin Biopsies in General Internal Medicine: Facts and Myths. ⁶²	Bailleux S...Nikkels AF	35430724	2022
49	Rheopheresis: A narrative review. ⁶²	Kosmadakis G	35389284	2022
50	Hemodialysis Patient with Streptococcal Toxic Shock Syndrome and Penile Necrosis: A Case Report. ⁶²	Nakai K...Hatta T	35650128	2022

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Genes for Calciphylaxis

Genes related to Calciphylaxis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FGF23	Fibroblast Growth Factor 23	Protein Coding	13.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	ALB	Albumin	Protein Coding	13.59	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	CASR	Calcium Sensing Receptor	Protein Coding	13.4	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	EPO	Erythropoietin	Protein Coding	13.07	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	VDR	Vitamin D Receptor	Protein Coding	12.34	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
6	NT5E	5'-Nucleotidase Ecto	Protein Coding	11.28	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	FN1	Fibronectin 1	Protein Coding	10.73	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
8	PTH	Parathyroid Hormone	Protein Coding	8.38	DISEASES inferred ¹⁴
9	MGP	Matrix Gla Protein	Protein Coding	8.34	DISEASES inferred ¹⁴
10	AHSG	Alpha 2-HS Glycoprotein	Protein Coding	7.47	DISEASES inferred ¹⁴
11	CD40LG	CD40 Ligand	Protein Coding	7.35	GeneCards inferred via : Publications (show sections)
12	CD79A	CD79a Molecule	Protein Coding	7.35	GeneCards inferred via : Publications (show sections)
13	GGCX	Gamma-Glutamyl Carboxylase	Protein Coding	6.27	DISEASES inferred ¹⁴

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Variations for Calciphylaxis

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Expression for Calciphylaxis

Search GEO for disease gene expression data for Calciphylaxis.

Sources

Pathways for Calciphylaxis

Pathways related to Calciphylaxis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Vitamin D receptor pathway ⁷⁴	11.81	VDR PTH FGF23
2	Ca, cAMP and Lipid Signaling ³	11.53	VDR CASR ALB
3	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.31	PTH FN1 CD79A
4	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	11.29	FN1 FGF23 ALB AHSG
5	Warfarin Pathway, Pharmacodynamics ⁶⁰ Show member pathways Vitamin K metabolism and activation of dependent proteins ⁷⁴ vitamin K-epoxide cycle ⁶¹	10.95	MGP GGCX
6	Inflammatory response pathway ⁷⁴	10.92	FN1 CD40LG
7	FGF23 signaling in hypophosphatemic rickets and related disorders ⁷⁴	10.66	PTH FGF23
8	Vitamin D metabolism ⁷⁴	9.96	VDR PTH

Sources

GO Terms for Calciphylaxis

Cellular components related to Calciphylaxis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:0031093	9.1	FN1 ALB AHSG

Biological processes related to Calciphylaxis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	10.1	VDR PTH FN1 FGF23 CASR
2	ossification	GO:0001503	9.91	MGP CASR AHSG
3	negative regulation of bone mineralization	GO:0030502	9.78	FGF23 AHSG
4	phosphate ion homeostasis	GO:0055062	9.76	PTH FGF23
5	acute-phase response	GO:0006953	9.73	FN1 EPO AHSG
6	cellular response to vitamin D	GO:0071305	9.67	CASR FGF23
7	response to fibroblast growth factor	GO:0071774	9.62	PTH CASR
8	calcium ion homeostasis	GO:0055074	9.55	PTH NT5E FGF23
9	positive regulation of vitamin D 24-hydroxylase activity	GO:0010980	9.26	VDR FGF23
10	regulation of bone mineralization	GO:0030500	9.02	MGP FGF23 AHSG

Sources

Sources for Calciphylaxis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CLC001 MIFTS: 50	Calciphylaxis Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Metabolic diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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