Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 76 3 15
Enteric Campylobacteriosis 73
Campylobacter Infections 44
Campylobacter Infection 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 44 D002169
SNOMED-CT 68 86500004

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted by ingestion of contaminated food or water or transmitted by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to brucellosis and q fever, and has symptoms including diarrhea or has_symptom dysentery, abdominal cramps and fever. An important gene associated with Campylobacteriosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and IL-2 Pathway. The drugs Rifaximin and rifamycin SV have been mentioned in the context of this disorder. Affiliated tissues include intestine, liver and bone, and related phenotypes are growth/size/body region and cardiovascular system

CDC : 3 Learn more about the multistate outbreak of multidrug-resistant Campylobacter infections linked to pet store puppies

Wikipedia : 76 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 brucellosis 30.0 IFNG SLC11A1 TLR4
2 q fever 30.0 IFNG IL1B TLR4
3 toxoplasmosis 30.0 IFNG IL1B TLR4
4 chlamydia 30.0 IFNG IL1B TLR4
5 gastrointestinal system disease 29.9 IFNG IL1B TLR4
6 salmonellosis 28.2 IFNG IL1B JUN SLC11A1 STAT1 TLR4
7 inflammatory bowel disease 26.5 IFNG IL1B JUN SLC11A1 STAT1 TLR4
8 prosthetic joint infection 10.7 IL1B TLR4
9 suppurative otitis media 10.6 IL1B TLR4
10 endometrial disease 10.6 IL1B TLR4
11 variola major 10.6 IFNG TLR4
12 hemorrhagic cystitis 10.6 JUN TLR4
13 cysticercosis 10.6 IL1B TLR4
14 staphylococcal toxic shock syndrome 10.6 IFNG IL1B
15 autoimmune myocarditis 10.6 IFNG IL1B
16 myositis fibrosa 10.6 IFNG TLR4
17 scrub typhus 10.5 IL1B TLR4
18 crohn's colitis 10.5 IFNG IL1B
19 middle ear disease 10.5 IL1B TLR4
20 fascioliasis 10.5 IFNG IL1B
21 perinatal necrotizing enterocolitis 10.5 IL1B TLR4
22 septic arthritis 10.5 IFNG TLR4
23 eales disease 10.5 IFNG IL1B
24 eumycotic mycetoma 10.5 IFNG IL1B
25 aseptic meningitis 10.4 IFNG IL1B
26 buruli ulcer 10.4 IFNG SLC11A1
27 enterobiasis 10.4 SLC11A1 TLR4
28 idiopathic neutropenia 10.4 IL1B TLR4
29 spondylosis 10.3 IL1B VDR
30 coccidioidomycosis 10.3 STAT1 TLR4
31 uterine anomalies 10.3 IL1B TLR4
32 invasive aspergillosis 10.3 IFNG TLR4
33 hand, foot and mouth disease 10.3 IFNG VDR
34 pertussis 10.2 IL1B JUN TLR4
35 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 IFNG IL1B TLR4
36 toxic shock syndrome 10.2 IFNG IL1B TLR4
37 intestinal disease 10.2 IFNG IL1B TLR4
38 respiratory system disease 10.2 IFNG IL1B TLR4
39 chagas disease 10.2 IFNG IL1B TLR4
40 periodontitis 10.2 IFNG IL1B TLR4
41 multidrug-resistant tuberculosis 10.2 SLC11A1 VDR
42 human t-cell leukemia virus type 2 10.2 IFNG STAT1
43 histoplasmosis 10.2 IFNG STAT1
44 idiopathic hypercalciuria 10.2 IL1B VDR
45 chronic inflammatory demyelinating polyradiculoneuropathy 10.2 IFNG STAT1
46 colitis 10.2 IFNG IL1B TLR4
47 behcet syndrome 10.2 IFNG IL1B TLR4
48 monocytic leukemia 10.2 IFNG IL1B JUN
49 paracoccidioidomycosis 10.2 IFNG TLR4
50 bacterial vaginosis 10.1 IL1B TLR4

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • diarrhea or has_symptom dysentery
  • abdominal cramps
  • fever

UMLS symptoms related to Campylobacteriosis:


fever, pruritus

MGI Mouse Phenotypes related to Campylobacteriosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 VDR IL1B TLR4 JUN HCFC1 IFNG
2 cardiovascular system MP:0005385 9.95 VDR IL1B TLR4 JUN IFNG STAT1
3 hematopoietic system MP:0005397 9.95 VDR TLR4 JUN SLC11A1 IFNG STAT1
4 immune system MP:0005387 9.91 VDR TLR4 JUN SLC11A1 IFNG STAT1
5 digestive/alimentary MP:0005381 9.85 VDR TLR4 SLC11A1 IFNG STAT1
6 integument MP:0010771 9.8 JUN VDR IFNG STAT1 IL1B TLR4
7 mortality/aging MP:0010768 9.76 JUN VDR HCFC1 SLC11A1 IFNG STAT1
8 liver/biliary system MP:0005370 9.65 TLR4 JUN HCFC1 IFNG STAT1
9 neoplasm MP:0002006 9.35 SLC11A1 IFNG STAT1 IL1B TLR4
10 skeleton MP:0005390 9.1 VDR IL1B TLR4 JUN IFNG STAT1

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173
2 rifamycin SV Phase 2, Phase 3
3 Rifamycins Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
5 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3
7 Antibiotics, Antitubercular Phase 2, Phase 3
8 Anti-Infective Agents Phase 2, Phase 3
9
Aluminum hydroxide Approved, Investigational Phase 2,Phase 1 21645-51-2
10 Vaccines Phase 2,Phase 1
11
Aluminum sulfate Approved Phase 1 10043-01-3
12 Adjuvants, Immunologic Phase 1
13 Antacids Phase 1
14 Anti-Ulcer Agents Phase 1
15
Formaldehyde Approved, Vet_approved 50-00-0 712
16 Ether
17 Disinfectants
18 Antitubercular Agents
19 Cola Nutraceutical

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Efficacy of Rifaximin in Preventing Campylobacteriosis Completed NCT02280044 Phase 2, Phase 3
2 ACE393-103 Vaccination Challenge Study Unknown status NCT00859716 Phase 2
3 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
4 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
5 Safety Study of a Capsule-Conjugate Vaccine to Prevent Campylobacter-Caused Diarrhea Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
6 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
7 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
8 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
9 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Recruiting NCT03266068
10 Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota Active, not recruiting NCT02040922
11 Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates Terminated NCT02232373 Not Applicable

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

19
Intestine

MalaCards organs/tissues related to Campylobacteriosis:

41
Liver, Bone, Testes

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 263)
# Title Authors Year
1
Immune response-eliciting exposure to Campylobacter vastly exceeds the incidence of clinically overt campylobacteriosis but is associated with similar risk factors: A nationwide serosurvey in the Netherlands. ( 29746943 )
2018
2
A six-year epidemiological surveillance study in Split-Dalmatia County, Croatia: urban versus rural differences in human campylobacteriosis incidence. ( 29869522 )
2018
3
Knowledge gaps in control of Campylobacter for prevention of campylobacteriosis. ( 29663680 )
2018
4
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
5
Ruminant and chicken: important sources of campylobacteriosis in France despite a variation of source attribution in 2009 and 2015. ( 29915208 )
2018
6
Campylobacteriosis in dogs and cats: a review. ( 29756542 )
2018
7
Prevalence of Thermophilic <i>Campylobacter</i> in Cattle Production at Slaughterhouse Level in France and Link Between <i>C. jejuni</i> Bovine Strains and Campylobacteriosis. ( 29615999 )
2018
8
Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. ( 29408609 )
2018
9
Food safety labelling of chicken to prevent campylobacteriosis: consumer expectations and current practices. ( 29587692 )
2018
10
Cytokine responses in campylobacteriosis: Linking pathogenesis to immunity. ( 29550265 )
2018
11
MLST genotypes of Campylobacter jejuni isolated from broiler products, dairy cattle and human campylobacteriosis cases in Lithuania. ( 28619013 )
2017
12
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
13
Spatio-temporal outbreaks of campylobacteriosis and the role of fresh-milk vending machines in the Czech Republic: A methodological study. ( 29239559 )
2017
14
Epidemiology of campylobacteriosis in Denmark 2000-2015. ( 28597535 )
2017
15
Outbreak of Campylobacteriosis Following a Dairy Farm Visit: Confirmation by Genotyping. ( 28350214 )
2017
16
A systematic review and meta-analysis on the incubation period of Campylobacteriosis. ( 28669361 )
2017
17
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
18
The recurrent campylobacteriosis epidemic over Christmas and New Year in European countries, 2006-2014. ( 28693589 )
2017
19
Occupational Distribution of Campylobacteriosis and Salmonellosis Cases - Maryland, Ohio, and Virginia, 2014. ( 28817554 )
2017
20
Rifaximin fails to prevent campylobacteriosis in the human challenge model: a randomized, double-blind, placebo-controlled trial. ( 29145631 )
2017
21
Occupational Animal Exposure Among Persons with Campylobacteriosis and Cryptosporidiosis - Nebraska, 2005-2015. ( 28910275 )
2017
22
Pet-associated Campylobacteriosis: A persisting public health concern. ( 28834267 )
2017
23
Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. ( 29268955 )
2017
24
Source attribution of human campylobacteriosis at the point of exposure by combining comparative exposure assessment and subtype comparison based on comparative genomic fingerprinting. ( 28837643 )
2017
25
Extreme precipitation events and increased risk of campylobacteriosis in Maryland, U.S.A. ( 27214137 )
2016
26
Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver PActAc Using PFGE and WGS. ( 27334628 )
2016
27
Non food-related risk factors of campylobacteriosis in Canada: a matched case-control study. ( 27677338 )
2016
28
Campylobacteriosis in the South Bohemian RegionA - aA Recurrent Problem. ( 27690477 )
2016
29
Association between community socioeconomic factors, animal feeding operations, and campylobacteriosis incidence rates: Foodborne Diseases Active Surveillance Network (FoodNet), 2004-2010. ( 27450432 )
2016
30
Filling gaps in notification data: a model-based approach applied to travel related campylobacteriosis cases in New Zealand. ( 27600394 )
2016
31
Trends in the Epidemiology of Campylobacteriosis in Israel (1999-2012). ( 27203409 )
2016
32
Combining QMRA and Epidemiology to Estimate Campylobacteriosis Incidence. ( 26889674 )
2016
33
Campylobacteriosis in Poland in 2013 and 2014 ( 27779836 )
2016
34
Factors associated with increasing campylobacteriosis incidence in Michigan, 2004-2013. ( 27488877 )
2016
35
Outbreak of Campylobacteriosis Associated with Raccoon Contact at a Wildlife Rehabilitation Centre, Minnesota, 2013. ( 27576067 )
2016
36
Campylobacteriosis: the role of poultry meat. ( 26686808 )
2016
37
Estimating healthcare costs of acute gastroenteritis and human campylobacteriosis in Switzerland. ( 27513710 )
2016
38
The campylobacteriosis conundrum - examining the incidence of infection with Campylobacter sp. in Australia, 1998-2013. ( 27938447 )
2016
39
Human Campylobacteriosis in Luxembourg, 2010-2013: A Case-Control Study Combined with Multilocus Sequence Typing for Source Attribution and Risk Factor Analysis. ( 26860258 )
2016
40
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health. ( 26679515 )
2016
41
Acute Gastroenteritis and Campylobacteriosis in Swiss Primary Care: The Viewpoint of General Practitioners. ( 27603141 )
2016
42
Calling all Campy - how routine investigation and molecular characterization impacts the understanding of campylobacteriosis epidemiology - Alaska, United States, 2004-2013. ( 26119636 )
2015
43
Prevalence and risk factors associated with bovine genital campylobacteriosis and bovine trichomonosis in the state of Pernambuco, Brazil. ( 25633914 )
2015
44
[Campylobacteriosis at the Department of Infectious Diseases of the University Hospital Brno in 2011-2013: a retrospective study]. ( 26448303 )
2015
45
Using geovisual analytics in Google Earth to understand disease distribution: a case study of campylobacteriosis in the Czech Republic (2008-2012). ( 25628063 )
2015
46
Effect of Antimicrobial Use in Agricultural Animals on Drug-resistant Foodborne Campylobacteriosis in Humans: A Systematic Literature Review. ( 26580432 )
2015
47
Brucellosis, genital campylobacteriosis and other factors affecting calving rate of cattle in three states of Northern Nigeria. ( 25601264 )
2015
48
Notes from the field: campylobacteriosis outbreak associated with consuming undercooked chicken liver pActAc - ohio and Oregon, december 2013-january 2014. ( 25879900 )
2015
49
Seasonality of Campylobacter jejuni isolates associated with human campylobacteriosis in the Manawatu region, New Zealand. ( 26344515 )
2015
50
Human campylobacteriosis related to the consumption of raw milk sold by vending machines in Italy: Quantitative risk assessment based on official controls over four years. ( 26142145 )
2015

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 IFNG IL1B JUN STAT1 TLR4
2
Show member pathways
12.64 IFNG IL1B JUN TLR4
3
Show member pathways
12.57 HCFC1 IFNG IL1B JUN STAT1 TLR4
4
Show member pathways
12.53 IFNG IL1B JUN STAT1
5
Show member pathways
12.37 IL1B JUN TLR4
6
Show member pathways
12.34 IL1B JUN STAT1
7
Show member pathways
12.3 JUN STAT1 TLR4
8
Show member pathways
12.29 IFNG IL1B JUN
9
Show member pathways
12.25 IFNG IL1B JUN STAT1 TLR4
10
Show member pathways
12.2 IFNG IL1B JUN
11
Show member pathways
12.1 IL1B JUN STAT1
12
Show member pathways
12.09 IFNG IL1B STAT1 TLR4
13
Show member pathways
12.08 IL1B JUN STAT1
14 12.05 IFNG STAT1 TLR4
15
Show member pathways
12.04 IFNG IL1B JUN STAT1 TLR4
16
Show member pathways
11.99 IFNG IL1B JUN STAT1 TLR4
17 11.97 IFNG IL1B JUN
18
Show member pathways
11.95 IFNG JUN STAT1
19
Show member pathways
11.95 IFNG IL1B JUN STAT1
20 11.93 IFNG IL1B JUN STAT1
21 11.91 IFNG IL1B STAT1 TLR4 VDR
22 11.9 IFNG IL1B TLR4
23
Show member pathways
11.9 IL1B JUN STAT1 TLR4
24
Show member pathways
11.85 IFNG IL1B JUN STAT1
25
Show member pathways
11.85 IFNG IL1B JUN STAT1 TLR4
26 11.83 IFNG IL1B JUN
27 11.79 IL1B JUN STAT1
28 11.78 IFNG IL1B TLR4
29 11.73 IFNG IL1B JUN TLR4
30 11.7 IFNG JUN STAT1
31 11.69 IFNG IL1B JUN TLR4
32 11.66 IL1B JUN TLR4
33
Show member pathways
11.57 IFNG IL1B JUN
34
Show member pathways
11.57 IFNG IL1B JUN STAT1 TLR4
35 11.52 IFNG JUN STAT1
36 11.44 IFNG IL1B TLR4
37 11.42 IFNG IL1B JUN
38 11.42 IFNG IL1B TLR4
39 11.28 IFNG IL1B STAT1
40 11.24 IFNG IL1B
41 11.24 IL1B TLR4
42 11.2 IFNG IL1B
43 11.17 IFNG IL1B
44
Show member pathways
11.15 IFNG JUN
45 11.13 IFNG JUN
46 11.1 IFNG JUN
47 11.08 IFNG IL1B
48 11.01 IFNG JUN
49 10.72 JUN TLR4
50 10.58 IFNG IL1B JUN VDR

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 HCFC1 IL1B JUN STAT1
2 positive regulation of cell proliferation GO:0008284 9.86 IFNG IL1B JUN STAT1
3 immune response GO:0006955 9.85 IFNG IL1B SLC11A1 TLR4
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 HCFC1 IFNG JUN STAT1 VDR
5 response to lipopolysaccharide GO:0032496 9.62 IL1B JUN SLC11A1 TLR4
6 positive regulation of epithelial cell migration GO:0010634 9.61 IFNG JUN
7 positive regulation of phagocytosis GO:0050766 9.61 IL1B SLC11A1
8 response to bacterium GO:0009617 9.6 SLC11A1 TLR4
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 IL1B TLR4
10 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TLR4
11 cellular response to organic cyclic compound GO:0071407 9.58 HCFC1 IL1B STAT1
12 positive regulation of interleukin-12 production GO:0032735 9.57 IFNG TLR4
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 IFNG IL1B
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 STAT1 TLR4
15 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.51 IFNG STAT1
16 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 HCFC1 IL1B JUN SLC11A1 STAT1 TLR4
17 positive regulation of interferon-alpha production GO:0032727 9.49 STAT1 TLR4
18 negative regulation of interleukin-17 production GO:0032700 9.48 IFNG TLR4
19 macrophage activation GO:0042116 9.46 SLC11A1 TLR4
20 positive regulation of interferon-gamma production GO:0032729 9.43 IL1B SLC11A1 TLR4
21 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG IL1B
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.33 IFNG IL1B TLR4
23 positive regulation of gene expression GO:0010628 9.1 HCFC1 IFNG IL1B SLC11A1 TLR4 VDR

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.96 JUN STAT1
2 activating transcription factor binding GO:0033613 8.62 HCFC1 JUN

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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