MCID: CMP002
MIFTS: 46

Campylobacteriosis

Categories: Gastrointestinal diseases, Infectious diseases

Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 74 15 17
Enteric Campylobacteriosis 71
Campylobacter Infections 43
Campylobacter Infection 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 43 D002169
SNOMED-CT 67 86500004
UMLS 71 C0006818 C0275982

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted by ingestion of contaminated food or water or transmitted by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to diarrhea and reactive arthritis, and has symptoms including fever, diarrhea and abdominal cramps. An important gene associated with Campylobacteriosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Measles and T cell receptor signaling pathway. The drugs Rifaximin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and liver, and related phenotypes are growth/size/body region and mortality/aging

Wikipedia : 74 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 diarrhea 31.0 TLR4 STAT1 IL1B IFNG
2 reactive arthritis 30.9 TLR4 SLC11A1 IL1B IFNG
3 brucellosis 30.8 TLR4 SLC11A1 IFNG
4 listeriosis 30.8 TLR4 PATE1 IL1B
5 hepatitis a 30.5 TLR4 IL1B IFNG
6 chlamydia 30.5 TLR4 IL1B IFNG
7 prosthetic joint infection 30.4 TLR4 IL1B
8 crohn's disease 30.4 TLR4 SLC11A1 IL1B IFNG
9 bacterial infectious disease 30.4 TLR4 SLC11A1 IL1B IFNG
10 q fever 30.3 TLR4 SLC11A1 IL1B IFNG
11 toxoplasmosis 30.3 TLR4 STAT1 IL1B IFNG
12 appendicitis 30.2 TLR4 IL1B IFNG
13 peritonitis 30.0 TLR4 IL1B IFNG
14 typhoid fever 30.0 TLR4 SLC11A1 IL1B IFNG
15 inflammatory bowel disease 29.7 VDR TLR4 STAT1 SLC11A1 JUN IL1B
16 salmonellosis 29.5 VDR TLR4 STAT1 SLC11A1 NPL JUN
17 gastroenteritis 10.8
18 guillain-barre syndrome 10.5
19 staphylococcal toxic shock syndrome 10.5 IL1B IFNG
20 metal allergy 10.4 TLR4 IL1B
21 trichomoniasis 10.4
22 infertility 10.4
23 type 1 diabetes mellitus 17 10.4 VDR SLC11A1
24 human t-cell leukemia virus type 2 10.4 STAT1 IFNG
25 gastrointestinal tularemia 10.4 TLR4 SLC11A1
26 hemorrhagic cystitis 10.4 TLR4 JUN IL1B
27 petrositis 10.4 IFNG CCS
28 scrub typhus 10.4 TLR4 IL1B IFNG
29 hidradenitis suppurativa 10.4 TLR4 IL1B IFNG
30 hidradenitis 10.4 TLR4 IL1B IFNG
31 tularemia 10.4 TLR4 SLC11A1 IL1B
32 septic arthritis 10.4 TLR4 IL1B IFNG
33 nasal cavity disease 10.4 TLR4 IL1B IFNG
34 aphthous stomatitis 10.4 TLR4 IL1B IFNG
35 stomatitis 10.4 TLR4 IL1B IFNG
36 lymph node disease 10.4 TLR4 IL1B IFNG
37 toxic shock syndrome 10.3 TLR4 IL1B IFNG
38 splenic disease 10.3 TLR4 SLC11A1 IFNG
39 nose disease 10.3 TLR4 IL1B IFNG
40 autoimmune disease of gastrointestinal tract 10.3 TLR4 IL1B IFNG
41 tonsillitis 10.3 TLR4 IL1B IFNG
42 hand, foot and mouth disease 10.3 VDR TLR4 IFNG
43 macs syndrome 10.3 STAT1 SLC11A1 IFNG
44 pyelonephritis 10.3 TLR4 IL1B IFNG
45 aggressive periodontitis 10.3 VDR TLR4 IL1B
46 intervertebral disc disease 10.3 VDR IL1B IFNG
47 contact dermatitis 10.3 TLR4 IL1B IFNG
48 eales disease 10.3 IL1B IFNG
49 bacterial meningitis 10.3 TLR4 IL1B IFNG
50 rubella 10.3 TLR4 IL1B IFNG

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • fever
  • diarrhea
  • abdominal cramps
  • dysentery

UMLS symptoms related to Campylobacteriosis:


fever, pruritus

MGI Mouse Phenotypes related to Campylobacteriosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.73 ASPA CDK2AP1 ETV5 HCFC1 IFNG IL1B
2 mortality/aging MP:0010768 9.44 ASPA CDK2AP1 ETV5 HCFC1 IFNG IL1B

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173 46783403
2
Azithromycin Approved Phase 2, Phase 3 83905-01-5 447043 55185
3 Antibiotics, Antitubercular Phase 2, Phase 3
4 Gastrointestinal Agents Phase 2, Phase 3
5 Anti-Bacterial Agents Phase 2, Phase 3
6 Anti-Infective Agents Phase 2, Phase 3
7 Spirulina Phase 2
8
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
9
Aluminum sulfate Approved Phase 1 10043-01-3
10 Vaccines Phase 1
11 Antacids Phase 1
12 Adjuvants, Immunologic Phase 1
13 Anti-Ulcer Agents Phase 1
14 Immunologic Factors Phase 1
15
Formaldehyde Approved, Vet_approved 50-00-0 712
16 Disinfectants
17 Ether
18 Cola

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Double Blind, Placebo-Controlled Trial Assessing the Efficacy of Rifaximin in Preventing Campylobacteriosis in Subjects Challenged With Campylobacter Jejuni Completed NCT02280044 Phase 2, Phase 3
2 Efficacy of Supplemental Protein, Delivered Alone or in Combination With Treatment for Enteric Pathogens, to Prevent Growth Faltering in Bangladeshi Infants Recruiting NCT03683667 Phase 2, Phase 3 Azithromycin Oral Product;Placebos
3 A Randomized, Double-Blind, Placebo Controlled Vaccination-Challenge Study of ACE393 to Determine Efficacy Against the Symptoms of Moderate to Severe Campylobacter Jejuni Infection in Normal Healthy Volunteers Unknown status NCT00859716 Phase 2
4 A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-De-escalation Study of LMN-101in Healthy Volunteers Challenged With Campylobacter Jejuni Not yet recruiting NCT04182490 Phase 2
5 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
6 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
7 Safety and Immunogenicity Evaluation of an Intramuscular Capsule-Conjugate Campylobacter Vaccine (CJCV1) Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
8 An Observational Study of the Role of Antibiotics, Inflammation and Changes in Microbiota in the Development of Post-infective Bowel Dysfunction Following Infection With Campylobacter Jejuni or Coli Unknown status NCT02040922
9 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
10 Evaluation of Immunochromatographic Tests for Campylobacter Detection in Stools Completed NCT02274922
11 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
12 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
13 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Active, not recruiting NCT03266068
14 Arthritis in Assiut University Children Hospital Not yet recruiting NCT04326582

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ciprofloxacin
ERYTHROMYCIN PWDR

Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

19
Intestine

MalaCards organs/tissues related to Campylobacteriosis:

40
Colon, Liver, Testes, Bone, Skin, Breast, Tonsil

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 1334)
# Title Authors PMID Year
1
Associations of five food- and water-borne diseases with ecological zone, land use and aquifer type in a changing climate. 61
32570317 2020
2
Survey of the U.S. Broiler Industry Regarding Pre- and Postharvest Interventions Targeted To Mitigate Campylobacter Contamination on Broiler Chicken Products. 61
32084667 2020
3
Campylobacter risk for the consumers of wastewater-irrigated vegetables based on field experiments. 61
32171131 2020
4
Antimicrobial Resistance Determinants Circulating among Thermophilic Campylobacter Isolates Recovered from Broilers in Ireland Over a One-Year Period. 61
32521746 2020
5
Oral Immunization of Chickens with Lactococcus lactis Expressing cjaA Temporarily Reduces Campylobacter jejuni Colonization. 61
31718285 2020
6
Association between private drinking water wells and the incidence of Campylobacteriosis in Maryland: An ecological analysis using Foodborne Diseases Active Surveillance Network (FoodNet) data (2007-2016). 61
32559686 2020
7
Microevolution of Campylobacter jejuni during long-term infection in an immunocompromised host. 61
32572150 2020
8
Genetic diversity, antimicrobial resistance, and virulence genes of thermophilic Campylobacter isolated from broiler production chain. 61
32514993 2020
9
Epidemiology of Campylobacter infections in Ireland 2004-2016: What has changed? 61
32144864 2020
10
Detection of Campylobacter species in different types of samples from dairy farms. 61
31727852 2020
11
Campylobacter contamination of broilers: the role of transport and slaughterhouse. 61
32163798 2020
12
Identifying the environmental drivers of Campylobacter infection risk in southern Ontario, Canada using a One Health approachs. 61
32363811 2020
13
Prevalence and risk factors of Campylobacter infection in broiler and cockerel flocks in Mymensingh and Gazipur districts of Bangladesh. 61
32460154 2020
14
Antimicrobial resistance of Campylobacter isolates recovered from broilers in the Republic of Ireland in 2017 and 2018: an update. 61
32329627 2020
15
Characteristics of Campylobacter Gastroenteritis Outbreaks in Australia, 2001 to 2016. 61
31738586 2020
16
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota. 61
32443576 2020
17
Tetracycline resistance transmission in Campylobacter is promoted at temperatures resembling the avian reservoir. 61
32402330 2020
18
Response to letter of comments: Comments on a retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina). Highlighting a neglected agent: Leptospira sp. 61
31492445 2020
19
The Use of Bacteriophages in the Poultry Industry. 61
32443410 2020
20
Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis. 61
32466564 2020
21
Molecular Characterization and Antimicrobial Susceptibility of C. jejuni Isolates from Italian Wild Bird Populations. 61
32326051 2020
22
Concurrent Escherichia coli tubo-ovarian abscess and Campylobacter jejuni gastroenteritis: A case report. 61
32257830 2020
23
Campylobacter gastroenteritis in children in north-eastern Israel comparison with other common pathogens. 61
32242070 2020
24
Induction of neutrophil extracellular traps by Campylobacter jejuni. 61
32329205 2020
25
Antimicrobial Resistance and Virulence Properties of Campylobacter Spp. Originating from Domestic Geese in Poland. 61
32344537 2020
26
Research Note: Lyophilization of hyperimmune egg yolk: effect on antibody titer and protection of broilers against Campylobacter colonization. 61
32241501 2020
27
Comparison of relative expressions of genes involved in iron acquisition and regulation in fluoroquinolone-resistant and wild-type Campylobacter jejuni. 61
32273001 2020
28
Clinically Relevant Campylobacter jejuni Subtypes Are Readily Found and Transmitted within the Cattle Production Continuum but Present a Limited Foodborne Risk. 61
31862718 2020
29
Occurrence and antimicrobial resistance of Campylobacter jejuni isolates from poultry in Casablanca-Settat, Morocco. 61
32300573 2020
30
DNA-based faecal source tracking of contaminated drinking water causing a large Campylobacter outbreak in Norway 2019. 61
31748129 2020
31
Bridging the Gap: A Role for Campylobacterjejuni Biofilms. 61
32210099 2020
32
Epidemiology and antimicrobial resistance of Campylobacter spp. in animals in Sub-Saharan Africa: A systematic review. 61
32181402 2020
33
Role of Cecal Microbiota in the Differential Resistance of Inbred Chicken Lines to Colonization by Campylobacter jejuni. 61
31980428 2020
34
Zoonotic implications of camel diseases in Iran. 61
32160657 2020
35
Novel Clinical Campylobacter jejuni Infection Models Based on Sensitization of Mice to Lipooligosaccharide, a Major Bacterial Factor Triggering Innate Immune Responses in Human Campylobacteriosis. 61
32231139 2020
36
Prevalence of Campylobacter and Salmonella in African food animals and meat: A systematic review and meta-analysis. 61
31710971 2020
37
Vitamin C alleviates acute enterocolitis in Campylobacter jejuni infected mice. 61
32076081 2020
38
Recurrent Campylobacter Enteritis in Patients with Hypogammaglobulinemia: Review of the Literature. 61
32085573 2020
39
Differential Distribution of the wlaN and cgtB Genes, Associated with Guillain-Barré Syndrome, in Campylobacter jejuni Isolates from Humans, Broiler Chickens, and Wild Birds. 61
32110976 2020
40
Campylobacteriosis associated with the consumption of unpasteurised milk: findings from a sentinel surveillance site. 61
32014081 2020
41
An outbreak of campylobacteriosis at a hotel in England: the ongoing risk due to consumption of chicken liver dishes. 61
32070452 2020
42
Campylobacteriosis Agents in Meat Carcasses Collected from Two District Municipalities in the Eastern Cape Province, South Africa. 61
32079101 2020
43
Shifts in the Molecular Epidemiology of Campylobacter jejuni Infections in a Sentinel Region of New Zealand following Implementation of Food Safety Interventions by the Poultry Industry. 61
31862724 2020
44
Effect of Lactobacillus spp. on adhesion, invasion, and translocation of Campylobacter jejuni in chicken and pig small-intestinal epithelial cell lines. 61
32013961 2020
45
Contribution of Epithelial Apoptosis and Subepithelial Immune Responses in Campylobacter jejuni-Induced Barrier Disruption. 61
32210941 2020
46
MLST-based genetic relatedness of Campylobacter jejuni isolated from chickens and humans in Poland. 61
31978059 2020
47
Campylobacter jejuni Strain Dynamics in a Raccoon (Procyon lotor) Population in Southern Ontario, Canada: High Prevalence and Rapid Subtype Turnover. 61
32118057 2020
48
Molecular and phenotypical investigation of ciprofloxacin resistance among Campylobacter jejuni strains of human origin: high prevalence of resistance in Turkey. 61
31692136 2020
49
Detection and quantification of Campylobacter spp. in Brazilian poultry processing plants. 61
32088692 2020
50
Campylobacter outbreak associated with raw drinking milk, North West England, 2016. 61
32000879 2020

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 TLR4 STAT1 JUN IL1B IFNG
2
Show member pathways
12.5 TLR4 STAT1 JUN IL1B IFNG
3
Show member pathways
12.48 TLR4 STAT1 JUN IL1B IFNG
4 12.16 TLR4 STAT1 JUN IL1B
5
Show member pathways
12.15 TLR4 STAT1 JUN IL1B IFNG
6
Show member pathways
12.12 TLR4 STAT1 IL1B IFNG
7
Show member pathways
12.04 TLR4 STAT1 JUN IL1B IFNG
8 11.97 VDR TLR4 STAT1 IL1B IFNG
9 11.92 STAT1 JUN IL1B IFNG
10
Show member pathways
11.89 TLR4 STAT1 JUN IL1B
11
Show member pathways
11.87 TLR4 STAT1 JUN IL1B IFNG
12 11.85 JUN IL1B IFNG
13 11.83 TLR4 IL1B IFNG
14 11.81 STAT1 JUN IL1B
15
Show member pathways
11.73 STAT1 IL1B IFNG
16 11.72 STAT1 JUN IFNG
17 11.7 TLR4 JUN IL1B IFNG
18 11.67 TLR4 JUN IL1B
19
Show member pathways
11.66 TLR4 STAT1 IL1B IFNG
20
Show member pathways
11.59 JUN IL1B IFNG
21 11.54 STAT1 JUN IFNG
22 11.47 TLR4 IL1B IFNG
23 11.43 TLR4 IL1B IFNG
24 11.42 JUN IL1B IFNG
25
Show member pathways
11.41 STAT1 JUN IL1B IFNG ETV5
26 11.27 STAT1 IL1B IFNG
27 11.11 VDR JUN IL1B IFNG
28 11.1 JUN IFNG ETV5
29
Show member pathways
11.05 TLR4 STAT1 JUN IL1B IFNG
30 10.71 TLR4 JUN

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10 VDR TLR4 STAT1 SLC11A1 JUN IL1B
2 positive regulation of cell proliferation GO:0008284 9.92 STAT1 SHMT2 JUN IL1B IFNG
3 response to lipopolysaccharide GO:0032496 9.73 TLR4 SLC11A1 JUN IL1B
4 positive regulation of inflammatory response GO:0050729 9.71 TLR4 IL1B IFNG
5 cellular response to organic cyclic compound GO:0071407 9.67 STAT1 IL1B HCFC1
6 response to mechanical stimulus GO:0009612 9.65 STAT1 KCNK2 JUN
7 astrocyte activation GO:0048143 9.6 IL1B IFNG
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.59 IL1B IFNG
9 negative regulation of interleukin-17 production GO:0032700 9.58 TLR4 IFNG
10 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.58 STAT1 IFNG
11 positive regulation of phagocytosis GO:0050766 9.58 SLC11A1 IL1B IFNG
12 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IL1B IFNG
13 macrophage activation GO:0042116 9.56 TLR4 SLC11A1
14 positive regulation of interferon-alpha production GO:0032727 9.55 TLR4 STAT1
15 positive regulation of interferon-gamma production GO:0032729 9.54 TLR4 SLC11A1 IL1B
16 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 TLR4 IFNG
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 TLR4 IL1B IFNG
18 positive regulation of interleukin-6 secretion GO:2000778 9.43 TLR4 IL1B IFNG
19 positive regulation of gene expression GO:0010628 9.43 VDR TLR4 SLC11A1 IL1B IFNG HCFC1
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B IFNG
21 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 8.8 TLR4 STAT1 IFNG

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.17 TLR4 STAT1 SHMT2 NPL JUN HCFC1

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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