MCID: CMP002
MIFTS: 51

Campylobacteriosis

Categories: Gastrointestinal diseases

Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 76 3 15
Enteric Campylobacteriosis 73
Campylobacter Infections 44
Campylobacter Infection 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 44 D002169
SNOMED-CT 68 86500004

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted by ingestion of contaminated food or water or transmitted by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to brucellosis and q fever, and has symptoms including fever, abdominal cramps and diarrhea or has_symptom dysentery. An important gene associated with Campylobacteriosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are IL-2 Pathway and Human cytomegalovirus infection. The drugs Rifaximin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related phenotypes are growth/size/body region and cardiovascular system

CDC : 3 Get answers to frequently asked questions about Campylobacter

Wikipedia : 76 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 brucellosis 30.0 IFNG SLC11A1 TLR4
2 q fever 30.0 IFNG IL1B TLR4
3 chlamydia 30.0 IFNG IL1B TLR4
4 toxoplasmosis 30.0 IFNG IL1B TLR4
5 gastrointestinal system disease 29.9 IFNG IL1B TLR4
6 salmonellosis 29.7 IFNG IL1B JUN SLC11A1 STAT1 TLR4
7 inflammatory bowel disease 28.9 IFNG IL1B JUN SLC11A1 STAT1 TLR4
8 trichomoniasis 10.3
9 prosthetic joint infection 10.2 IL1B TLR4
10 suppurative otitis media 10.2 IL1B TLR4
11 endometrial disease 10.2 IL1B TLR4
12 cysticercosis 10.2 IL1B TLR4
13 hemorrhagic cystitis 10.2 JUN TLR4
14 variola major 10.2 IFNG TLR4
15 spondylosis 10.2 IL1B VDR
16 scrub typhus 10.2 IL1B TLR4
17 middle ear disease 10.2 IL1B TLR4
18 staphylococcal toxic shock syndrome 10.2 IFNG IL1B
19 listeriosis 10.2
20 diarrhea 10.2
21 myositis fibrosa 10.2 IFNG TLR4
22 perinatal necrotizing enterocolitis 10.2 IL1B TLR4
23 ascaris lumbricoides infection 10.2 IFNG IL1B
24 crohn's colitis 10.1 IFNG IL1B
25 hyper ige syndrome 10.1 IFNG TLR4
26 central nervous system vasculitis 10.1 IFNG IL1B
27 extrinsic cardiomyopathy 10.1 IL1B TLR4
28 hand, foot and mouth disease 10.1 IFNG TLR4
29 fascioliasis 10.1 IFNG IL1B
30 coccidioidomycosis 10.1 STAT1 TLR4
31 idiopathic neutropenia 10.1 IL1B TLR4
32 primary systemic mycosis 10.1 IFNG IL1B
33 idiopathic hypercalciuria 10.1 IL1B VDR
34 eales disease 10.1 IFNG IL1B
35 eumycotic mycetoma 10.1 IFNG IL1B
36 aseptic meningitis 10.1 IFNG IL1B
37 invasive aspergillosis 10.1 IFNG TLR4
38 prostatitis 10.1 IL1B VDR
39 bacterial vaginosis 10.1 IL1B TLR4
40 central nervous system tuberculosis 10.1 IL1B STAT1
41 human t-cell leukemia virus type 2 10.1 IFNG STAT1
42 shigellosis 10.1
43 gastroenteritis 10.1
44 lepromatous leprosy 10.1 IFNG VDR
45 enterobiasis 10.1 SLC11A1 TLR4
46 autoimmune uveitis 10.1 IFNG IL1B
47 paracoccidioidomycosis 10.1 IFNG TLR4
48 pertussis 10.1 IL1B JUN TLR4
49 multidrug-resistant tuberculosis 10.1 SLC11A1 VDR
50 toxic shock syndrome 10.1 IFNG IL1B TLR4

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • fever
  • abdominal cramps
  • diarrhea or has_symptom dysentery

UMLS symptoms related to Campylobacteriosis:


fever, pruritus

MGI Mouse Phenotypes related to Campylobacteriosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.98 HCFC1 IFNG IL1B JUN STAT1 TLR4
2 cardiovascular system MP:0005385 9.95 IFNG IL1B JUN STAT1 TLR4 VDR
3 hematopoietic system MP:0005397 9.95 IFNG IL1B JUN SLC11A1 STAT1 TLR4
4 immune system MP:0005387 9.91 IFNG IL1B JUN SLC11A1 STAT1 TLR4
5 digestive/alimentary MP:0005381 9.85 IFNG SLC11A1 STAT1 TLR4 VDR
6 integument MP:0010771 9.8 IFNG IL1B JUN STAT1 TLR4 VDR
7 mortality/aging MP:0010768 9.76 HCFC1 IFNG IL1B JUN SLC11A1 STAT1
8 liver/biliary system MP:0005370 9.65 HCFC1 IFNG JUN STAT1 TLR4
9 neoplasm MP:0002006 9.35 IFNG IL1B SLC11A1 STAT1 TLR4
10 skeleton MP:0005390 9.1 IFNG IL1B JUN STAT1 TLR4 VDR

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173
2
Azithromycin Approved Phase 2, Phase 3 83905-01-5 55185 447043
3 rifamycin SV Phase 2, Phase 3
4 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
5 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
6 Antibiotics, Antitubercular Phase 2, Phase 3
7 Anti-Infective Agents Phase 2, Phase 3,Phase 3
8 Rifamycins Phase 2, Phase 3
9 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
10
Aluminum hydroxide Approved, Investigational Phase 2,Phase 1 21645-51-2
11 Immunologic Factors Phase 2,Phase 1
12 Vaccines Phase 2,Phase 1
13
Aluminum sulfate Approved Phase 1 10043-01-3
14 Anti-Ulcer Agents Phase 1
15 Antacids Phase 1
16 Adjuvants, Immunologic Phase 1
17
Formaldehyde Approved, Vet_approved 50-00-0 712
18 Disinfectants
19 Ether
20 Cola
21 Antitubercular Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy of Rifaximin in Preventing Campylobacteriosis Completed NCT02280044 Phase 2, Phase 3
2 Protein Plus: Improving Infant Growth Through Diet and Enteric Health Recruiting NCT03683667 Phase 2, Phase 3 Azithromycin Oral Product;Placebos
3 ACE393-103 Vaccination Challenge Study Unknown status NCT00859716 Phase 2
4 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
5 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
6 Safety Study of a Capsule-Conjugate Vaccine to Prevent Campylobacter-Caused Diarrhea Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
7 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
8 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
9 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
10 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Recruiting NCT03266068
11 Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota Active, not recruiting NCT02040922
12 Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates Terminated NCT02232373 Not Applicable

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

MalaCards organs/tissues related to Campylobacteriosis:

41
Liver, Bone, Testes, Tonsil, Prostate, T Cells, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

19
Intestine

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 270)
# Title Authors Year
1
Immune response-eliciting exposure to Campylobacter vastly exceeds the incidence of clinically overt campylobacteriosis but is associated with similar risk factors: A nationwide serosurvey in the Netherlands. ( 29746943 )
2018
2
A six-year epidemiological surveillance study in Split-Dalmatia County, Croatia: urban versus rural differences in human campylobacteriosis incidence. ( 29869522 )
2018
3
Knowledge gaps in control of Campylobacter for prevention of campylobacteriosis. ( 29663680 )
2018
4
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
5
Ruminant and chicken: important sources of campylobacteriosis in France despite a variation of source attribution in 2009 and 2015. ( 29915208 )
2018
6
Campylobacteriosis in dogs and cats: a review. ( 29756542 )
2018
7
Prevalence of Thermophilic <i>Campylobacter</i> in Cattle Production at Slaughterhouse Level in France and Link Between <i>C. jejuni</i> Bovine Strains and Campylobacteriosis. ( 29615999 )
2018
8
Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. ( 29408609 )
2018
9
Pet-associated Campylobacteriosis: A persisting public health concern. ( 28834267 )
2018
10
Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. ( 29268955 )
2018
11
Cytokine responses in campylobacteriosis: Linking pathogenesis to immunity. ( 29550265 )
2018
12
Food safety labelling of chicken to prevent campylobacteriosis: consumer expectations and current practices. ( 29587692 )
2018
13
Exposure to whole chicken carcasses may present a greater risk of campylobacteriosis compared to exposure to chicken drumsticks. ( 29998484 )
2018
14
Antibiotic resistance, molecular characterizations, and clinical manifestations of Campylobacteriosis at a military medical center in Hawaii from 2012-2016: a retrospective analysis. ( 30082843 )
2018
15
The role of whey on the performance and campylobacteriosis in broiler chicks. ( 30165581 )
2018
16
Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin. ( 30186251 )
2018
17
Chicken Liver-Associated Outbreaks of Campylobacteriosis and Salmonellosis, United States, 2000-2016: Identifying Opportunities for Prevention. ( 30192164 )
2018
18
A retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina). ( 30466651 )
2018
19
MLST genotypes of Campylobacter jejuni isolated from broiler products, dairy cattle and human campylobacteriosis cases in Lithuania. ( 28619013 )
2017
20
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
21
Spatio-temporal outbreaks of campylobacteriosis and the role of fresh-milk vending machines in the Czech Republic: A methodological study. ( 29239559 )
2017
22
Epidemiology of campylobacteriosis in Denmark 2000-2015. ( 28597535 )
2017
23
Outbreak of Campylobacteriosis Following a Dairy Farm Visit: Confirmation by Genotyping. ( 28350214 )
2017
24
A systematic review and meta-analysis on the incubation period of Campylobacteriosis. ( 28669361 )
2017
25
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
26
The recurrent campylobacteriosis epidemic over Christmas and New Year in European countries, 2006-2014. ( 28693589 )
2017
27
Occupational Distribution of Campylobacteriosis and Salmonellosis Cases - Maryland, Ohio, and Virginia, 2014. ( 28817554 )
2017
28
Rifaximin fails to prevent campylobacteriosis in the human challenge model: a randomized, double-blind, placebo-controlled trial. ( 29145631 )
2017
29
Occupational Animal Exposure Among Persons with Campylobacteriosis and Cryptosporidiosis - Nebraska, 2005-2015. ( 28910275 )
2017
30
Source attribution of human campylobacteriosis at the point of exposure by combining comparative exposure assessment and subtype comparison based on comparative genomic fingerprinting. ( 28837643 )
2017
31
Extreme precipitation events and increased risk of campylobacteriosis in Maryland, U.S.A. ( 27214137 )
2016
32
Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver PActAc Using PFGE and WGS. ( 27334628 )
2016
33
Non food-related risk factors of campylobacteriosis in Canada: a matched case-control study. ( 27677338 )
2016
34
Campylobacteriosis in the South Bohemian RegionA - aA Recurrent Problem. ( 27690477 )
2016
35
Association between community socioeconomic factors, animal feeding operations, and campylobacteriosis incidence rates: Foodborne Diseases Active Surveillance Network (FoodNet), 2004-2010. ( 27450432 )
2016
36
Filling gaps in notification data: a model-based approach applied to travel related campylobacteriosis cases in New Zealand. ( 27600394 )
2016
37
Trends in the Epidemiology of Campylobacteriosis in Israel (1999-2012). ( 27203409 )
2016
38
Combining QMRA and Epidemiology to Estimate Campylobacteriosis Incidence. ( 26889674 )
2016
39
Campylobacteriosis in Poland in 2013 and 2014 ( 27779836 )
2016
40
Factors associated with increasing campylobacteriosis incidence in Michigan, 2004-2013. ( 27488877 )
2016
41
Outbreak of Campylobacteriosis Associated with Raccoon Contact at a Wildlife Rehabilitation Centre, Minnesota, 2013. ( 27576067 )
2016
42
Campylobacteriosis: the role of poultry meat. ( 26686808 )
2016
43
Estimating healthcare costs of acute gastroenteritis and human campylobacteriosis in Switzerland. ( 27513710 )
2016
44
The campylobacteriosis conundrum - examining the incidence of infection with Campylobacter sp. in Australia, 1998-2013. ( 27938447 )
2016
45
Human Campylobacteriosis in Luxembourg, 2010-2013: A Case-Control Study Combined with Multilocus Sequence Typing for Source Attribution and Risk Factor Analysis. ( 26860258 )
2016
46
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health. ( 26679515 )
2016
47
Acute Gastroenteritis and Campylobacteriosis in Swiss Primary Care: The Viewpoint of General Practitioners. ( 27603141 )
2016
48
Calling all Campy - how routine investigation and molecular characterization impacts the understanding of campylobacteriosis epidemiology - Alaska, United States, 2004-2013. ( 26119636 )
2015
49
Prevalence and risk factors associated with bovine genital campylobacteriosis and bovine trichomonosis in the state of Pernambuco, Brazil. ( 25633914 )
2015
50
[Campylobacteriosis at the Department of Infectious Diseases of the University Hospital Brno in 2011-2013: a retrospective study]. ( 26448303 )
2015

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.05 IFNG IL1B JUN STAT1 TLR4
2
Show member pathways
12.89 IL1B JUN STAT1 TLR4
3
Show member pathways
12.85 IFNG IL1B JUN STAT1 TLR4
4
Show member pathways
12.55 IFNG IL1B JUN STAT1
5
Show member pathways
12.53 HCFC1 IFNG IL1B JUN STAT1 TLR4
6
Show member pathways
12.43 IFNG IL1B JUN STAT1 TLR4
7
Show member pathways
12.34 IL1B JUN STAT1
8
Show member pathways
12.29 IFNG IL1B JUN
9
Show member pathways
12.21 JUN STAT1 TLR4
10
Show member pathways
12.2 IFNG IL1B JUN
11
Show member pathways
12.1 IFNG IL1B JUN STAT1 TLR4
12
Show member pathways
12.09 IL1B JUN STAT1
13
Show member pathways
12.09 IFNG IL1B STAT1 TLR4
14
Show member pathways
12.08 IL1B JUN STAT1
15 12.06 IFNG STAT1 TLR4
16
Show member pathways
11.99 IFNG IL1B JUN STAT1 TLR4
17 11.98 IFNG IL1B JUN
18
Show member pathways
11.96 IFNG JUN STAT1
19
Show member pathways
11.94 IFNG IL1B JUN STAT1
20
Show member pathways
11.93 IFNG IL1B TLR4
21 11.93 IFNG IL1B JUN STAT1
22 11.91 IFNG IL1B STAT1 TLR4 VDR
23 11.9 IFNG IL1B TLR4
24
Show member pathways
11.9 IL1B JUN STAT1 TLR4
25 11.83 IFNG IL1B JUN
26
Show member pathways
11.83 IFNG IL1B JUN STAT1
27 11.79 IL1B JUN STAT1
28 11.78 IFNG IL1B TLR4
29
Show member pathways
11.77 IFNG IL1B JUN STAT1 TLR4
30 11.71 IFNG IL1B JUN TLR4
31 11.7 IFNG JUN STAT1
32 11.67 IFNG IL1B JUN TLR4
33 11.66 IL1B JUN TLR4
34
Show member pathways
11.57 IFNG IL1B JUN
35 11.52 IFNG JUN STAT1
36 11.44 IFNG IL1B TLR4
37 11.42 IFNG IL1B JUN
38 11.42 IFNG IL1B TLR4
39 11.28 IFNG IL1B STAT1
40 11.25 IFNG IL1B
41 11.24 IL1B TLR4
42 11.2 IFNG IL1B
43 11.15 IFNG IL1B
44
Show member pathways
11.15 IFNG JUN
45
Show member pathways
11.14 IFNG IL1B JUN STAT1 TLR4
46 11.13 IFNG JUN
47 11.1 IFNG JUN
48 11.08 IFNG IL1B
49 11.02 IFNG JUN
50 10.91 IFNG IL1B JUN VDR

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.88 HCFC1 IL1B JUN STAT1
2 positive regulation of cell proliferation GO:0008284 9.87 IFNG IL1B JUN STAT1
3 immune response GO:0006955 9.86 IFNG IL1B SLC11A1 TLR4
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.83 HCFC1 IFNG JUN STAT1 VDR
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.79 IL1B JUN TLR4
6 response to organic cyclic compound GO:0014070 9.71 IL1B JUN STAT1
7 positive regulation of phagocytosis GO:0050766 9.62 IL1B SLC11A1
8 positive regulation of epithelial cell migration GO:0010634 9.61 IFNG JUN
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.6 IL1B TLR4
10 positive regulation of interleukin-8 production GO:0032757 9.59 IL1B TLR4
11 positive regulation of interleukin-12 production GO:0032735 9.58 IFNG TLR4
12 cellular response to organic cyclic compound GO:0071407 9.58 HCFC1 IL1B STAT1
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.55 IFNG IL1B
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 STAT1 TLR4
15 positive regulation of interferon-alpha production GO:0032727 9.51 STAT1 TLR4
16 positive regulation of interferon-gamma production GO:0032729 9.5 IL1B SLC11A1 TLR4
17 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 HCFC1 IL1B JUN SLC11A1 STAT1 TLR4
18 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 IFNG STAT1
19 negative regulation of interleukin-17 production GO:0032700 9.48 IFNG TLR4
20 macrophage activation GO:0042116 9.46 SLC11A1 TLR4
21 response to lipopolysaccharide GO:0032496 9.46 IL1B JUN SLC11A1 TLR4
22 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 IFNG IL1B TLR4
23 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.37 IFNG IL1B
24 positive regulation of gene expression GO:0010628 9.1 HCFC1 IFNG IL1B SLC11A1 TLR4 VDR

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activating transcription factor binding GO:0033613 8.96 HCFC1 JUN
2 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000982 8.62 JUN STAT1

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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