MCID: CMP002
MIFTS: 46

Campylobacteriosis

Categories: Gastrointestinal diseases

Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 74 15 17
Enteric Campylobacteriosis 71
Campylobacter Infections 43
Campylobacter Infection 71

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 43 D002169
SNOMED-CT 67 86500004
UMLS 71 C0006818 C0275982

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted by ingestion of contaminated food or water or transmitted by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to dysentery and brucellosis, and has symptoms including fever, diarrhea and abdominal cramps. An important gene associated with Campylobacteriosis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Measles and T cell receptor signaling pathway. The drugs Rifaximin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include intestine, colon and testes, and related phenotypes are growth/size/body region and hematopoietic system

Wikipedia : 74 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 dysentery 30.8 TLR4 IL1B GPR182
2 brucellosis 30.8 TLR4 SLC11A1 IFNG
3 reactive arthritis 30.8 TLR4 SLC11A1 IL1B IFNG
4 chlamydia 30.5 TLR4 IL1B IFNG
5 prosthetic joint infection 30.4 TLR4 IL1B
6 crohn's disease 30.4 TLR4 SLC11A1 IL1B IFNG
7 peritonitis 30.3 TLR4 IL1B IFNG
8 bacterial infectious disease 30.3 TLR4 SLC11A1 IL1B IFNG
9 q fever 30.3 TLR4 SLC11A1 IL1B IFNG
10 toxoplasmosis 30.3 TLR4 STAT1 IL1B IFNG
11 appendicitis 30.2 TLR4 IL1B IFNG
12 myocarditis 30.1 TLR4 IL1B IFNG
13 immune deficiency disease 29.7 VDR STAT1 JUN IFNG
14 inflammatory bowel disease 29.6 VDR TLR4 STAT1 SLC11A1 JUN IL1B
15 salmonellosis 29.4 VDR TLR4 STAT1 SLC11A1 JUN IL1B
16 typhoid fever 28.9 TLR4 SLC11A1 IL1B IFNG HTRA1 GPR182
17 gastroenteritis 10.8
18 diarrhea 10.6
19 guillain-barre syndrome 10.5
20 staphylococcal toxic shock syndrome 10.5 IL1B IFNG
21 angelucci's syndrome 10.5 IL1B IFNG
22 trichomoniasis 10.4
23 infertility 10.4
24 human t-cell leukemia virus type 2 10.4 STAT1 IFNG
25 gastrointestinal tularemia 10.4 TLR4 SLC11A1
26 scrub typhus 10.4 TLR4 IL1B IFNG
27 aphthous stomatitis 10.4 TLR4 IL1B IFNG
28 stomatitis 10.4 TLR4 IL1B IFNG
29 commensal bacterial infectious disease 10.3 TLR4 IL1B IFNG
30 eales disease 10.3 IL1B IFNG
31 splenic disease 10.3 TLR4 SLC11A1 IFNG
32 toxic shock syndrome 10.3 TLR4 IL1B IFNG
33 tonsillitis 10.3 TLR4 IL1B IFNG
34 pyelonephritis 10.3 TLR4 IL1B IFNG
35 contact dermatitis 10.3 TLR4 IL1B IFNG
36 bacterial meningitis 10.3 TLR4 IL1B IFNG
37 aggressive periodontitis 10.3 VDR TLR4 IL1B
38 macs syndrome 10.3 STAT1 SLC11A1 IFNG
39 proteasome-associated autoinflammatory syndrome 1 10.3 TLR4 IL1B IFNG
40 panophthalmitis 10.3 NPL IFNG
41 intervertebral disc disease 10.3 VDR IL1B IFNG
42 coccidiosis 10.3 TLR4 IFNG ALLC
43 enterocolitis 10.3
44 testicular disease 10.3 TLR4 SLC11A1 IFNG
45 chronic fatigue syndrome 10.3 TLR4 IL1B IFNG
46 cutaneous leishmaniasis 10.3 TLR4 SLC11A1 IFNG
47 bronchial disease 10.3 TLR4 IL1B IFNG
48 otitis media 10.3 TLR4 IL1B IFNG
49 nickel allergic contact dermatitis 10.3 NPL IFNG
50 brain edema 10.3 JUN IL1B IFNG

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • fever
  • diarrhea
  • abdominal cramps
  • dysentery

UMLS symptoms related to Campylobacteriosis:


fever, pruritus

MGI Mouse Phenotypes related to Campylobacteriosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.93 ASPA CDK2AP1 HCFC1 HTRA1 IFNG IL1B
2 hematopoietic system MP:0005397 9.65 ASPA GPR182 IFNG IL1B JUN SHMT2
3 skeleton MP:0005390 9.32 ASPA EID2 GPR182 HTRA1 IFNG IL1B

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173 46783403
2
Azithromycin Approved Phase 2, Phase 3 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 2, Phase 3
4 Antibiotics, Antitubercular Phase 2, Phase 3
5 Anti-Infective Agents Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3
7 Spirulina Phase 2
8
Aluminum hydroxide Approved, Investigational Phase 1 21645-51-2
9
Aluminum sulfate Approved Phase 1 10043-01-3
10 Vaccines Phase 1
11 Immunologic Factors Phase 1
12 Adjuvants, Immunologic Phase 1
13 Anti-Ulcer Agents Phase 1
14 Antacids Phase 1
15
Formaldehyde Approved, Vet_approved 50-00-0 712
16 Antitubercular Agents
17 Ether
18 Disinfectants
19 Cola

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Double Blind, Placebo-Controlled Trial Assessing the Efficacy of Rifaximin in Preventing Campylobacteriosis in Subjects Challenged With Campylobacter Jejuni Completed NCT02280044 Phase 2, Phase 3
2 Efficacy of Supplemental Protein, Delivered Alone or in Combination With Treatment for Enteric Pathogens, to Prevent Growth Faltering in Bangladeshi Infants Recruiting NCT03683667 Phase 2, Phase 3 Azithromycin Oral Product;Placebos
3 A Randomized, Double-Blind, Placebo Controlled Vaccination-Challenge Study of ACE393 to Determine Efficacy Against the Symptoms of Moderate to Severe Campylobacter Jejuni Infection in Normal Healthy Volunteers Unknown status NCT00859716 Phase 2
4 A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Dose-De-escalation Study of LMN-101in Healthy Volunteers Challenged With Campylobacter Jejuni Not yet recruiting NCT04182490 Phase 2
5 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
6 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
7 Safety and Immunogenicity Evaluation of an Intramuscular Capsule-Conjugate Campylobacter Vaccine (CJCV1) Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
8 An Observational Study of the Role of Antibiotics, Inflammation and Changes in Microbiota in the Development of Post-infective Bowel Dysfunction Following Infection With Campylobacter Jejuni or Coli Unknown status NCT02040922
9 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
10 Evaluation of Immunochromatographic Tests for Campylobacter Detection in Stools Completed NCT02274922
11 Diagnosis of Neglected Tropical Diseases (NTDs) in Patients Presenting With Persistent Digestive Disorders (≥2 Weeks) in Côte d'Ivoire, Indonesia, Mali and Nepal Completed NCT02105714
12 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
13 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Recruiting NCT03266068

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ciprofloxacin
ERYTHROMYCIN PWDR

Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

19
Intestine

MalaCards organs/tissues related to Campylobacteriosis:

40
Colon, Testes, Liver, Bone, Skin, Tonsil, Breast

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 1288)
# Title Authors PMID Year
1
DNA-based faecal source tracking of contaminated drinking water causing a large Campylobacter outbreak in Norway 2019. 61
31748129 2020
2
Effect of Lactobacillus spp. on adhesion, invasion, and translocation of Campylobacter jejuni in chicken and pig small-intestinal epithelial cell lines. 61
32013961 2020
3
Prevalence of Campylobacter and Salmonella in African food animals and meat: A systematic review and meta-analysis. 61
31710971 2020
4
Campylobacteriosis associated with the consumption of unpasteurised milk: findings from a sentinel surveillance site. 61
32014081 2020
5
Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review. 61
32025233 2020
6
Carvacrol ameliorates acute campylobacteriosis in a clinical murine infection model. 61
31921356 2020
7
Campylobacter Abundance in Breastfed Infants and Identification of a New Species in the Global Enterics Multicenter Study. 61
31941810 2020
8
Campylobacter outbreak associated with raw drinking milk, North West England, 2016. 61
32000879 2020
9
Molecular and phenotypical investigation of ciprofloxacin resistance among Campylobacter jejuni strains of human origin: high prevalence of resistance in Turkey. 61
31692136 2020
10
MLST-based genetic relatedness of Campylobacter jejuni isolated from chickens and humans in Poland. 61
31978059 2020
11
Murine fecal microbiota transplantation lowers gastrointestinal pathogen loads and dampens pro-inflammatory immune responses in Campylobacter jejuni infected secondary abiotic mice. 61
31875037 2019
12
Genomic Analysis of Fluoroquinolone- and Tetracycline-Resistant Campylobacter jejuni Sequence Type 6964 in Humans and Poultry, New Zealand, 2014-2016. 61
31742539 2019
13
Shifts in the molecular epidemiology of Campylobacter jejuni infections in a sentinel region of New Zealand, following the implementation of food safety interventions by the poultry industry. 61
31862724 2019
14
Influence of cell history on the subsequent inactivation of Campylobacter jejuni during cold storage under modified atmosphere. 61
31421767 2019
15
Clinically-Relevant Campylobacter jejuni Subtypes are Readily Found and Transmitted within the Cattle Production Continuum but Present a Limited Foodborne Risk. 61
31862718 2019
16
Campylobacter jejuni Strains Associated with Wild Birds and Those Causing Human Disease in Six High-Use Recreational Waterways in New Zealand. 61
31562175 2019
17
Detection of Campylobacter species in different types of samples from dairy farms. 61
31727852 2019
18
Comments on a retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina). Highlighting a neglected agent: Leptospira sp. 61
31484084 2019
19
Spatio-temporal analysis of differences in campylobacteriosis incidence between urban and rural areas in the Southern District Health Board, New Zealand. 61
31677762 2019
20
Campylobacter subtypes detected in broiler ceca and livers collected at slaughter1. 61
31289821 2019
21
Dietary Saccharomyces cerevisiae boulardii CNCM I-1079 Positively Affects Performance and Intestinal Ecosystem in Broilers during a Campylobacter jejuni Infection. 61
31766507 2019
22
Prevalence and genetic diversity of Campylobacter spp. in the production chain of broiler chickens in Lebanon and its association with the intestinal protozoan Blastocystis sp. 61
31134283 2019
23
Characteristics of Campylobacter Gastroenteritis Outbreaks in Australia, 2001 to 2016. 61
31738586 2019
24
Campylobacteriosis in the Nordic countries from 2000 to 2015: Trends in time and space. 61
31763953 2019
25
Human campylobacteriosis: A public health concern of global importance. 61
31763476 2019
26
Oral Immunization of Chickens with Lactococcus lactis Expressing cjaA Temporarily Reduces Campylobacter jejuni Colonization. 61
31718285 2019
27
A systematic review of source attribution of human campylobacteriosis using multilocus sequence typing. 61
31662159 2019
28
A One Health approach to prevention, treatment, and control of campylobacteriosis. 61
31305492 2019
29
Peracetic acid reduces Campylobacter spp. numbers and total viable counts on broiler breast muscle and drumstick skins during modified atmosphere package storage. 61
31073589 2019
30
Occupational risk of salmonellosis and campylobacteriosis: a nationwide population-based registry study. 61
31413185 2019
31
Genome-Wide Prediction of Potential Vaccine Candidates for Campylobacter jejuni Using Reverse Vaccinology. 61
29128919 2019
32
Pathogenomics of Emerging Campylobacter Species. 61
31270126 2019
33
Campylobacter and antimicrobial resistance in dogs and humans: "One health" in practice. 61
31599545 2019
34
Prevalence, Virulence, and Antimicrobial Resistance of Campylobacter spp. in Raw Milk, Beef, and Pork Meat in Northern Poland. 61
31533265 2019
35
Current Status of Campylobacter Food Poisoning in Japan. 61
31998589 2019
36
Response to letter of comments: Comments on a retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina). Highlighting a neglected agent: Leptospira sp. 61
31492445 2019
37
Campylobacter species prevalence, characterisation of antimicrobial resistance and analysis of whole-genome sequence of isolates from livestock and humans, Latvia, 2008 to 2016. 61
31387670 2019
38
Emerging erm(B)-Mediated Macrolide Resistance Associated with Novel Multidrug Resistance Genomic Islands in Campylobacter. 61
31085517 2019
39
Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom. 61
31211671 2019
40
Detection and molecular typing of campylobacter isolates from human and animal faeces in coastal belt of Odisha, India. 61
32003331 2019
41
Species Identification of Campylobacter jejuni and Campylobacter coli Isolates from Raw Poultry Products by MALDI-TOF MS and rRNA Sequence Analysis. 61
31324272 2019
42
Novel narrow spectrum benzyl thiophene sulfonamide derivatives to control Campylobacter. 61
30918323 2019
43
Inhibition and Interactions of Campylobacter jejuni from Broiler Chicken Houses with Organic Acids. 61
31366094 2019
44
Campylobacter culture fails to correctly detect Campylobacter in 30% of positive patient stool specimens compared to non-cultural methods. 61
30783889 2019
45
Development and Evaluation of Two Live Salmonella-Vectored Vaccines for Campylobacter Control in Broiler Chickens. 61
30864853 2019
46
Proteome Profiling by Label-Free Mass Spectrometry Reveals Differentiated Response of Campylobacter jejuni 81-176 to Sublethal Concentrations of Bile Acids. 61
30246935 2019
47
Draft Whole-Genome Sequences of Three Isolates of a Novel Strain of a Campylobacter sp. Isolated from New Zealand Birds and Water. 61
31048398 2019
48
Current status of veterinary public health activities in Bangladesh and its future plans. 61
31117996 2019
49
Enhanced microbiological surveillance reveals that temporal case clusters contribute to the high rates of campylobacteriosis in a model agroecosystem. 61
31076242 2019
50
Metagenomic analysis of isolation methods of a targeted microbe, Campylobacter jejuni, from chicken feces with high microbial contamination. 61
31027515 2019

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.72 TLR4 STAT1 JUN IL1B IFNG
2
Show member pathways
12.49 TLR4 STAT1 JUN IL1B IFNG
3
Show member pathways
12.47 TLR4 STAT1 JUN IL1B IFNG
4 12.15 TLR4 STAT1 JUN IL1B
5
Show member pathways
12.13 TLR4 STAT1 JUN IL1B IFNG
6
Show member pathways
12.11 TLR4 STAT1 IL1B IFNG
7
Show member pathways
12 TLR4 STAT1 JUN IL1B IFNG
8 11.91 TLR4 JUN IL1B
9 11.91 VDR TLR4 STAT1 IL1B IFNG
10 11.9 TLR4 IL1B IFNG
11 11.9 STAT1 JUN IL1B IFNG
12
Show member pathways
11.87 TLR4 STAT1 JUN IL1B
13 11.84 JUN IL1B IFNG
14 11.82 TLR4 IL1B IFNG
15 11.81 STAT1 JUN IL1B
16
Show member pathways
11.81 STAT1 JUN IL1B IFNG
17
Show member pathways
11.77 TLR4 STAT1 JUN IL1B IFNG
18 11.71 STAT1 JUN IFNG
19
Show member pathways
11.71 STAT1 IL1B IFNG
20 11.67 TLR4 JUN IL1B
21 11.67 TLR4 JUN IL1B IFNG
22
Show member pathways
11.58 JUN IL1B IFNG
23 11.57 TLR4 JUN IL1B IFNG
24 11.54 STAT1 JUN IFNG
25 11.46 TLR4 IL1B IFNG
26 11.42 TLR4 IL1B IFNG
27 11.42 JUN IL1B IFNG
28 11.25 STAT1 IL1B IFNG
29
Show member pathways
11.14 TLR4 STAT1 JUN IL1B IFNG
30 10.91 VDR JUN IL1B IFNG
31 10.71 TLR4 JUN

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.93 VDR STAT1 JUN IFNG HCFC1 EID2
2 positive regulation of cell proliferation GO:0008284 9.92 STAT1 SHMT2 JUN IL1B IFNG
3 response to lipopolysaccharide GO:0032496 9.71 TLR4 SLC11A1 JUN IL1B
4 cellular response to organic cyclic compound GO:0071407 9.61 STAT1 IL1B HCFC1
5 astrocyte activation GO:0048143 9.58 IL1B IFNG
6 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.57 IL1B IFNG
7 negative regulation of interleukin-17 production GO:0032700 9.56 TLR4 IFNG
8 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.55 STAT1 IFNG
9 positive regulation of interferon-alpha production GO:0032727 9.54 TLR4 STAT1
10 positive regulation of phagocytosis GO:0050766 9.54 SLC11A1 IL1B IFNG
11 positive regulation of chemokine biosynthetic process GO:0045080 9.51 IL1B IFNG
12 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 TLR4 IL1B IFNG
13 macrophage activation GO:0042116 9.49 TLR4 SLC11A1
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 TLR4 IFNG
15 positive regulation of interferon-gamma production GO:0032729 9.43 TLR4 SLC11A1 IL1B
16 positive regulation of gene expression GO:0010628 9.43 VDR TLR4 SLC11A1 IL1B IFNG HCFC1
17 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.16 IL1B IFNG
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 8.8 TLR4 STAT1 IFNG

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.23 TLR4 STAT1 SHMT2 NPL JUN HTRA1

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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