MCID: CMP002
MIFTS: 50

Campylobacteriosis

Categories: Gastrointestinal diseases

Aliases & Classifications for Campylobacteriosis

MalaCards integrated aliases for Campylobacteriosis:

Name: Campylobacteriosis 12 77 15 17 3
Enteric Campylobacteriosis 74
Campylobacter Infections 45
Campylobacter Infection 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13622
MeSH 45 D002169
SNOMED-CT 69 86500004

Summaries for Campylobacteriosis

Disease Ontology : 12 A primary bacterial infectious disease that results in infection located in intestine, has material basis in Campylobacter jejuni, which is transmitted by ingestion of contaminated food or water or transmitted by contact with infected people or animals. The infection has symptom diarrhea or has symptom dysentery, has symptom abdominal cramps and pain, and has symptom fever.

MalaCards based summary : Campylobacteriosis, also known as enteric campylobacteriosis, is related to brucellosis and q fever, and has symptoms including fever, abdominal cramps and diarrhea or has_symptom dysentery. An important gene associated with Campylobacteriosis is IL1B (Interleukin 1 Beta), and among its related pathways/superpathways are IL-2 Pathway and Toll-like Receptor Signaling Pathway. The drugs Rifaximin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and testes, and related phenotypes are growth/size/body region and hematopoietic system

CDC : 3 Get answers to frequently asked questions about Campylobacter

Wikipedia : 77 Campylobacteriosis is an infection by the Campylobacter bacterium, most commonly C. jejuni. It is among... more...

Related Diseases for Campylobacteriosis

Diseases related to Campylobacteriosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 brucellosis 30.2 IFNG SLC11A1 TLR4
2 q fever 30.1 IFNG IL1B TLR4
3 chlamydia 30.1 IFNG IL1B TLR4
4 toxoplasmosis 30.1 IFNG IL1B TLR4
5 gastrointestinal system disease 30.0 IFNG IL1B TLR4
6 salmonellosis 29.9 IFNG IL1B SLC11A1 STAT1 TLR4 VDR
7 inflammatory bowel disease 29.8 IFNG IL1B STAT1 TLR4
8 prosthetic joint infection 10.3 IL1B TLR4
9 suppurative otitis media 10.3 IL1B TLR4
10 hemorrhagic cystitis 10.3 JUN TLR4
11 endometrial disease 10.3 IL1B TLR4
12 trichomoniasis 10.3
13 coccidioidomycosis 10.3 STAT1 TLR4
14 cysticercosis 10.3 IL1B TLR4
15 staphylococcal toxic shock syndrome 10.3 IFNG IL1B
16 variola major 10.2 IFNG TLR4
17 guillain-barre syndrome 10.2
18 crohn's colitis 10.2 IFNG IL1B
19 spondylosis 10.2 IL1B VDR
20 central nervous system vasculitis 10.2 IFNG IL1B
21 myositis fibrosa 10.2 IFNG TLR4
22 scrub typhus 10.2 IL1B TLR4
23 fascioliasis 10.2 IFNG IL1B
24 human t-cell leukemia virus type 2 10.2 IFNG STAT1
25 listeriosis 10.2
26 diarrhea 10.2
27 primary systemic mycosis 10.2 IFNG IL1B
28 enterobiasis 10.2 SLC11A1 TLR4
29 pertussis 10.2 IL1B JUN TLR4
30 eales disease 10.2 IFNG IL1B
31 eumycotic mycetoma 10.1 IFNG IL1B
32 middle ear disease 10.1 IL1B TLR4
33 multidrug-resistant tuberculosis 10.1 SLC11A1 VDR
34 buruli ulcer 10.1 IFNG SLC11A1
35 aseptic meningitis 10.1 IFNG IL1B
36 toxic shock syndrome 10.1 IFNG IL1B TLR4
37 shigellosis 10.1
38 gastroenteritis 10.1
39 proteasome-associated autoinflammatory syndrome 1 10.1 IFNG IL1B TLR4
40 chagas disease 10.1 IFNG IL1B TLR4
41 periodontitis 10.1 IFNG IL1B TLR4
42 respiratory system disease 10.1 IFNG IL1B TLR4
43 central nervous system tuberculosis 10.1 IL1B STAT1
44 monocytic leukemia 10.1 IFNG IL1B JUN
45 chronic mucocutaneous candidiasis 10.1 IFNG IL1B STAT1
46 extrapulmonary tuberculosis 10.1 IFNG IL1B SLC11A1
47 ulcerative colitis 10.1 IFNG IL1B TLR4
48 colitis 10.1 IFNG IL1B TLR4
49 behcet syndrome 10.1 IFNG IL1B TLR4
50 cutaneous leishmaniasis 10.1 IFNG SLC11A1 TLR4

Comorbidity relations with Campylobacteriosis via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Campylobacteriosis:



Diseases related to Campylobacteriosis

Symptoms & Phenotypes for Campylobacteriosis

Symptoms:

12
  • fever
  • abdominal cramps
  • diarrhea or has_symptom dysentery

UMLS symptoms related to Campylobacteriosis:


fever, pruritus

MGI Mouse Phenotypes related to Campylobacteriosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.01 CLPP HCFC1 IFNG IL1B JUN STAT1
2 hematopoietic system MP:0005397 9.97 CLPP IFNG IL1B JUN SLC11A1 STAT1
3 immune system MP:0005387 9.92 CLPP IFNG IL1B JUN SLC11A1 STAT1
4 mortality/aging MP:0010768 9.81 CLPP HCFC1 IFNG IL1B JUN SLC11A1
5 integument MP:0010771 9.8 CLPP IFNG IL1B JUN STAT1 TLR4
6 neoplasm MP:0002006 9.35 IFNG IL1B SLC11A1 STAT1 TLR4
7 skeleton MP:0005390 9.17 CLPP IFNG IL1B JUN STAT1 TLR4

Drugs & Therapeutics for Campylobacteriosis

Drugs for Campylobacteriosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifaximin Approved, Investigational Phase 2, Phase 3 80621-81-4 6436173 46783403
2
Azithromycin Approved Phase 2, Phase 3 83905-01-5 55185 447043
3 Anti-Bacterial Agents Phase 2, Phase 3,Phase 3
4 Anti-Infective Agents Phase 2, Phase 3,Phase 3
5 Antibiotics, Antitubercular Phase 2, Phase 3
6 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
7
Aluminum hydroxide Approved, Investigational Phase 2,Phase 1 21645-51-2
8 Vaccines Phase 2,Phase 1
9 Immunologic Factors Phase 2,Phase 1
10
Aluminum sulfate Approved Phase 1 10043-01-3
11 Antacids Phase 1
12 Anti-Ulcer Agents Phase 1
13 Adjuvants, Immunologic Phase 1
14
Formaldehyde Approved, Vet_approved 50-00-0 712
15 Ether
16 Disinfectants
17 Cola
18 Antitubercular Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Efficacy of Rifaximin in Preventing Campylobacteriosis Completed NCT02280044 Phase 2, Phase 3
2 Protein Plus: Improving Infant Growth Through Diet and Enteric Health Recruiting NCT03683667 Phase 2, Phase 3 Azithromycin Oral Product;Placebos
3 ACE393-103 Vaccination Challenge Study Unknown status NCT00859716 Phase 2
4 Campylobacter Jejuni Challenge Model Development: Dose Ranging Study Unknown status NCT00434798 Phase 1
5 Campylobacter Jejuni Challenge Model Development: Assessment of Homologous Protection Unknown status NCT01048112 Phase 1
6 Safety Study of a Capsule-Conjugate Vaccine to Prevent Campylobacter-Caused Diarrhea Completed NCT02067676 Phase 1 Alhydrogel®, aluminum hydroxide adjuvant (alum)
7 Retrospective Study of Bone Infection Due to Campylobacter Spp Completed NCT02884752
8 Diagnosis of Neglected Tropical Diseases Among Patients With Persistent Digestive Disorders Completed NCT02105714
9 Mucosal and Microbiota Changes During Acute Campylobacteriosis Recruiting NCT03223077
10 Epidemiology and Pathophysiology of Post-Infectious Functional GI Disorders Recruiting NCT03266068
11 Campylobacter Enteritis and Post-Infective Bowel Dysfunction (PI-BD): Role of Antibiotics and Microbiota Active, not recruiting NCT02040922
12 Campylobacter Enteritis and PI-BD: Dietary Reduction in Carbohydrates Terminated NCT02232373 Not Applicable

Search NIH Clinical Center for Campylobacteriosis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: campylobacter infections

Genetic Tests for Campylobacteriosis

Anatomical Context for Campylobacteriosis

MalaCards organs/tissues related to Campylobacteriosis:

42
Liver, Bone, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Campylobacteriosis:

20
Intestine

Publications for Campylobacteriosis

Articles related to Campylobacteriosis:

(show top 50) (show all 274)
# Title Authors Year
1
Campylobacteriosis Outbreak Associated with Contaminated Municipal Water Supply - Nebraska, 2017. ( 30789878 )
2019
2
Immune response-eliciting exposure to Campylobacter vastly exceeds the incidence of clinically overt campylobacteriosis but is associated with similar risk factors: A nationwide serosurvey in the Netherlands. ( 29746943 )
2018
3
A six-year epidemiological surveillance study in Split-Dalmatia County, Croatia: urban versus rural differences in human campylobacteriosis incidence. ( 29869522 )
2018
4
Knowledge gaps in control of Campylobacter for prevention of campylobacteriosis. ( 29663680 )
2018
5
Campylobacteriosis, Salmonellosis, Yersiniosis, and Listeriosis as Zoonotic Foodborne Diseases: A Review. ( 29701663 )
2018
6
Ruminant and chicken: important sources of campylobacteriosis in France despite a variation of source attribution in 2009 and 2015. ( 29915208 )
2018
7
Campylobacteriosis in dogs and cats: a review. ( 29756542 )
2018
8
Prevalence of Thermophilic <i>Campylobacter</i> in Cattle Production at Slaughterhouse Level in France and Link Between <i>C. jejuni</i> Bovine Strains and Campylobacteriosis. ( 29615999 )
2018
9
Microbiota-derived Metabolic Factors Reduce Campylobacteriosis in Mice. ( 29408609 )
2018
10
Food safety labelling of chicken to prevent campylobacteriosis: consumer expectations and current practices. ( 29587692 )
2018
11
Cytokine responses in campylobacteriosis: Linking pathogenesis to immunity. ( 29550265 )
2018
12
Human Campylobacteriosis in Italy: Emergence of Multi-Drug Resistance to Ciprofloxacin, Tetracycline, and Erythromycin. ( 30186251 )
2018
13
Chicken Liver-Associated Outbreaks of Campylobacteriosis and Salmonellosis, United States, 2000-2016: Identifying Opportunities for Prevention. ( 30192164 )
2018
14
A retrospective epidemiological analysis of shared risk factors for bovine trichomoniasis and bovine genital campylobacteriosis in La Pampa province (Argentina). ( 30466651 )
2018
15
Dairy Cattle, a Potential Reservoir of Human Campylobacteriosis: Epidemiological and Molecular Characterization of Campylobacter jejuni From Cattle Farms. ( 30619204 )
2018
16
Diagnosis of Bovine Genital Campylobacteriosis in South America. ( 30619902 )
2018
17
Campylobacteriosis in Poland in 2015 and 2016 ( 30808866 )
2018
18
Exposure to whole chicken carcasses may present a greater risk of campylobacteriosis compared to exposure to chicken drumsticks. ( 29998484 )
2018
19
Antibiotic resistance, molecular characterizations, and clinical manifestations of Campylobacteriosis at a military medical center in Hawaii from 2012-2016: a retrospective analysis. ( 30082843 )
2018
20
The role of whey on the performance and campylobacteriosis in broiler chicks. ( 30165581 )
2018
21
MLST genotypes of Campylobacter jejuni isolated from broiler products, dairy cattle and human campylobacteriosis cases in Lithuania. ( 28619013 )
2017
22
Burden of salmonellosis, campylobacteriosis and listeriosis: a time series analysis, Belgium, 2012 to 2020. ( 28935025 )
2017
23
Spatio-temporal outbreaks of campylobacteriosis and the role of fresh-milk vending machines in the Czech Republic: A methodological study. ( 29239559 )
2017
24
Epidemiology of campylobacteriosis in Denmark 2000-2015. ( 28597535 )
2017
25
Outbreak of Campylobacteriosis Following a Dairy Farm Visit: Confirmation by Genotyping. ( 28350214 )
2017
26
A systematic review and meta-analysis on the incubation period of Campylobacteriosis. ( 28669361 )
2017
27
Different Age Distribution between Campylobacteriosis and Nontyphoidal Salmonellosis in Hospitalized Korean Children with Acute Inflammatory Diarrhea. ( 28581280 )
2017
28
The recurrent campylobacteriosis epidemic over Christmas and New Year in European countries, 2006-2014. ( 28693589 )
2017
29
Occupational Distribution of Campylobacteriosis and Salmonellosis Cases - Maryland, Ohio, and Virginia, 2014. ( 28817554 )
2017
30
Rifaximin fails to prevent campylobacteriosis in the human challenge model: a randomized, double-blind, placebo-controlled trial. ( 29145631 )
2017
31
Occupational Animal Exposure Among Persons with Campylobacteriosis and Cryptosporidiosis - Nebraska, 2005-2015. ( 28910275 )
2017
32
Pet-associated Campylobacteriosis: A persisting public health concern. ( 28834267 )
2017
33
Residential proximity to high-density poultry operations associated with campylobacteriosis and infectious diarrhea. ( 29268955 )
2017
34
Source attribution of human campylobacteriosis at the point of exposure by combining comparative exposure assessment and subtype comparison based on comparative genomic fingerprinting. ( 28837643 )
2017
35
Extreme precipitation events and increased risk of campylobacteriosis in Maryland, U.S.A. ( 27214137 )
2016
36
Confirmation of a Campylobacteriosis Outbreak Associated with Chicken Liver PActAc Using PFGE and WGS. ( 27334628 )
2016
37
Non food-related risk factors of campylobacteriosis in Canada: a matched case-control study. ( 27677338 )
2016
38
Campylobacteriosis in the South Bohemian RegionA - aA Recurrent Problem. ( 27690477 )
2016
39
Association between community socioeconomic factors, animal feeding operations, and campylobacteriosis incidence rates: Foodborne Diseases Active Surveillance Network (FoodNet), 2004-2010. ( 27450432 )
2016
40
Filling gaps in notification data: a model-based approach applied to travel related campylobacteriosis cases in New Zealand. ( 27600394 )
2016
41
Trends in the Epidemiology of Campylobacteriosis in Israel (1999-2012). ( 27203409 )
2016
42
Combining QMRA and Epidemiology to Estimate Campylobacteriosis Incidence. ( 26889674 )
2016
43
Campylobacteriosis in Poland in 2013 and 2014 ( 27779836 )
2016
44
Factors associated with increasing campylobacteriosis incidence in Michigan, 2004-2013. ( 27488877 )
2016
45
Outbreak of Campylobacteriosis Associated with Raccoon Contact at a Wildlife Rehabilitation Centre, Minnesota, 2013. ( 27576067 )
2016
46
Campylobacteriosis: the role of poultry meat. ( 26686808 )
2016
47
Estimating healthcare costs of acute gastroenteritis and human campylobacteriosis in Switzerland. ( 27513710 )
2016
48
The campylobacteriosis conundrum - examining the incidence of infection with Campylobacter sp. in Australia, 1998-2013. ( 27938447 )
2016
49
Human Campylobacteriosis in Luxembourg, 2010-2013: A Case-Control Study Combined with Multilocus Sequence Typing for Source Attribution and Risk Factor Analysis. ( 26860258 )
2016
50
A review of sexually transmitted bovine trichomoniasis and campylobacteriosis affecting cattle reproductive health. ( 26679515 )
2016

Variations for Campylobacteriosis

Expression for Campylobacteriosis

Search GEO for disease gene expression data for Campylobacteriosis.

Pathways for Campylobacteriosis

Pathways related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.06 IFNG IL1B JUN STAT1 TLR4
2
Show member pathways
13.04 IFNG IL1B JUN STAT1 TLR4
3
Show member pathways
12.55 IFNG IL1B JUN STAT1
4
Show member pathways
12.45 IFNG IL1B JUN STAT1 TLR4
5
Show member pathways
12.33 HCFC1 IFNG IL1B JUN STAT1 TLR4
6
Show member pathways
12.21 JUN STAT1 TLR4
7
Show member pathways
12.2 IFNG IL1B JUN
8
Show member pathways
12.1 IL1B JUN STAT1
9
Show member pathways
12.1 IFNG IL1B JUN STAT1 TLR4
10
Show member pathways
12.09 IFNG IL1B STAT1 TLR4
11
Show member pathways
12.08 IL1B JUN STAT1
12 12.06 IFNG STAT1 TLR4
13
Show member pathways
11.99 IFNG IL1B JUN STAT1 TLR4
14 11.98 IFNG IL1B JUN
15
Show member pathways
11.95 IFNG JUN STAT1
16
Show member pathways
11.95 IFNG IL1B JUN STAT1
17 11.93 IFNG IL1B JUN STAT1
18
Show member pathways
11.92 IFNG IL1B TLR4
19 11.91 IFNG IL1B STAT1 TLR4 VDR
20 11.9 IFNG IL1B TLR4
21
Show member pathways
11.89 IL1B JUN STAT1 TLR4
22 11.83 IFNG IL1B JUN
23
Show member pathways
11.83 IFNG IL1B JUN STAT1
24 11.8 IL1B JUN STAT1
25 11.78 IFNG IL1B TLR4
26
Show member pathways
11.77 IFNG IL1B JUN STAT1 TLR4
27 11.72 IFNG IL1B JUN TLR4
28 11.69 IFNG JUN STAT1
29 11.67 IFNG IL1B JUN TLR4
30 11.66 IL1B JUN TLR4
31
Show member pathways
11.57 IFNG IL1B JUN
32 11.52 IFNG JUN STAT1
33 11.44 IFNG IL1B TLR4
34 11.42 IFNG IL1B JUN
35 11.42 IFNG IL1B TLR4
36 11.28 IFNG IL1B STAT1
37 11.27 IFNG IL1B
38 11.24 IL1B TLR4
39 11.2 IFNG IL1B
40 11.15 IFNG IL1B
41
Show member pathways
11.15 IFNG JUN
42
Show member pathways
11.14 IFNG IL1B JUN STAT1 TLR4
43 11.13 IFNG JUN
44 11.1 IFNG JUN
45 11.08 IFNG IL1B
46 11 IFNG JUN
47 10.91 IFNG IL1B JUN VDR
48 10.71 JUN TLR4

GO Terms for Campylobacteriosis

Biological processes related to Campylobacteriosis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.9 HCFC1 IL1B JUN STAT1
2 positive regulation of cell proliferation GO:0008284 9.88 IFNG IL1B JUN STAT1
3 immune response GO:0006955 9.86 IFNG IL1B SLC11A1 TLR4
4 negative regulation of transcription by RNA polymerase II GO:0000122 9.85 HCFC1 IFNG JUN STAT1 VDR
5 positive regulation of phagocytosis GO:0050766 9.61 IL1B SLC11A1
6 positive regulation of epithelial cell migration GO:0010634 9.61 IFNG JUN
7 lipopolysaccharide-mediated signaling pathway GO:0031663 9.59 IL1B TLR4
8 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TLR4
9 cellular response to organic cyclic compound GO:0071407 9.58 HCFC1 IL1B STAT1
10 positive regulation of interleukin-12 production GO:0032735 9.57 IFNG TLR4
11 response to organic cyclic compound GO:0014070 9.55 JUN STAT1
12 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 IFNG IL1B
13 positive regulation of interferon-gamma production GO:0032729 9.54 IL1B SLC11A1 TLR4
14 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.52 STAT1 TLR4
15 positive regulation of interferon-alpha production GO:0032727 9.51 STAT1 TLR4
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.5 IFNG IL1B TLR4
17 positive regulation of transcription by RNA polymerase II GO:0045944 9.5 HCFC1 IL1B JUN SLC11A1 STAT1 TLR4
18 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 IFNG STAT1
19 negative regulation of interleukin-17 production GO:0032700 9.48 IFNG TLR4
20 response to lipopolysaccharide GO:0032496 9.46 IL1B JUN SLC11A1 TLR4
21 macrophage activation GO:0042116 9.43 SLC11A1 TLR4
22 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 IFNG IL1B
23 positive regulation of gene expression GO:0010628 9.1 HCFC1 IFNG IL1B SLC11A1 TLR4 VDR

Molecular functions related to Campylobacteriosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.02 CLPP HCFC1 JUN STAT1 TLR4
2 activating transcription factor binding GO:0033613 8.96 HCFC1 JUN

Sources for Campylobacteriosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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