MCID: CNC014
MIFTS: 41

Cancer-Associated Retinopathy

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cancer-Associated Retinopathy

MalaCards integrated aliases for Cancer-Associated Retinopathy:

Name: Cancer-Associated Retinopathy 58 70
Paraneoplastic Retinopathy 58 70
Car Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
cancer-associated retinopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases


Summaries for Cancer-Associated Retinopathy

MalaCards based summary : Cancer-Associated Retinopathy, also known as paraneoplastic retinopathy, is related to autoimmune retinopathy and yemenite deaf-blind hypopigmentation syndrome. An important gene associated with Cancer-Associated Retinopathy is RCVRN (Recoverin), and among its related pathways/superpathways are Focal Adhesion and Metabolism of fat-soluble vitamins. Affiliated tissues include eye, lung and colon, and related phenotypes are photophobia and reduced visual acuity

Related Diseases for Cancer-Associated Retinopathy

Diseases related to Cancer-Associated Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 autoimmune retinopathy 32.2 ENO2 ENO1
2 yemenite deaf-blind hypopigmentation syndrome 30.5 VEGFA RHO
3 scotoma 30.5 VEGFA RHO RCVRN
4 melanoma-associated retinopathy 30.4 SAG RHO
5 neuroretinitis 30.3 SAG RCVRN ENO1
6 retinal degeneration 29.8 TULP1 SAG RHO RCVRN
7 macular retinal edema 29.7 VEGFA RHO PGF FLT1
8 chorioretinitis 29.7 VEGFA SAG
9 retinal detachment 29.6 VEGFA RHO ENO2
10 retinal artery occlusion 29.5 VEGFA PGF FLT1
11 proteinuria, chronic benign 29.3 VEGFA FLT1
12 congenital stationary night blindness 29.2 TULP1 SAG RHO RCVRN
13 microvascular complications of diabetes 5 29.2 VEGFA RHO PGF FLT1
14 retinal disease 29.2 TULP1 SAG RHO
15 cone dystrophy 28.8 TULP1 SAG RHO
16 eye disease 28.7 VEGFA SAG RHO PGF FLT1
17 retinitis pigmentosa 28.5 VEGFA TULP1 SAG RHO RCVRN ENO1
18 macular degeneration, age-related, 1 28.5 VEGFA SAG RHO RCVRN PGF FLT1
19 small cell carcinoma 10.3
20 paraneoplastic syndromes 10.3
21 interval angle-closure glaucoma 10.3 RCVRN ENO1
22 lymphocytic hypophysitis 10.2 ENO2 ENO1
23 skin granular cell tumor 10.2 ENO2 ENO1
24 retinitis 10.2
25 night blindness 10.2
26 small cell cancer of the lung 10.1
27 endometrial cancer 10.1
28 ifap syndrome 2 10.1
29 neuroendocrine carcinoma 10.1
30 patterned macular dystrophy 10.1 VEGFA RHO
31 neuropathy 10.1
32 chorioretinal scar 10.1 VEGFA RHO
33 large cell carcinoma with rhabdoid phenotype 10.1 VEGFA ENO2
34 retroperitoneal hemangiopericytoma 10.1 VEGFA ENO2
35 thymoma, familial 10.1
36 thymoma 10.1
37 retinal cancer 10.1
38 carcinoid syndrome 10.1 VEGFA ENO2
39 microcystic meningioma 10.1 VEGFA FLT1
40 myasthenic syndrome, congenital, 3a, slow-channel 10.1 SAG RHO
41 lipodermatosclerosis 10.1 VEGFA FLT1
42 angiokeratoma circumscriptum 10.1 VEGFA FLT1
43 glomeruloid hemangioma 10.1 VEGFA FLT1
44 tuberculous meningitis 10.1 VEGFA ENO2
45 primary cutaneous b-cell lymphoma 10.1 VEGFA FLT1
46 neonatal anemia 10.0 PGF FLT1
47 choroid disease 10.0 VEGFA RHO
48 lung non-squamous non-small cell carcinoma 10.0 VEGFA FLT1
49 severe nonproliferative diabetic retinopathy 10.0 VEGFA PGF
50 cerebellum cancer 10.0 SAG ENO2

Graphical network of the top 20 diseases related to Cancer-Associated Retinopathy:



Diseases related to Cancer-Associated Retinopathy

Symptoms & Phenotypes for Cancer-Associated Retinopathy

Human phenotypes related to Cancer-Associated Retinopathy:

58 31 (show all 34)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 58 31 frequent (33%) Frequent (79-30%) HP:0000613
2 reduced visual acuity 58 31 frequent (33%) Frequent (79-30%) HP:0007663
3 malignant genitourinary tract tumor 58 31 frequent (33%) Frequent (79-30%) HP:0006758
4 visual loss 58 31 frequent (33%) Frequent (79-30%) HP:0000572
5 neoplasm of the breast 58 31 frequent (33%) Frequent (79-30%) HP:0100013
6 small cell lung carcinoma 58 31 frequent (33%) Frequent (79-30%) HP:0030357
7 progressive visual field defects 58 31 frequent (33%) Frequent (79-30%) HP:0007987
8 autoimmune antibody positivity 58 31 frequent (33%) Frequent (79-30%) HP:0030057
9 photopsia 58 31 frequent (33%) Frequent (79-30%) HP:0030786
10 electronegative electroretinogram 58 31 frequent (33%) Frequent (79-30%) HP:0007984
11 adult-onset night blindness 58 31 frequent (33%) Frequent (79-30%) HP:0007830
12 optic disc pallor 58 31 occasional (7.5%) Occasional (29-5%) HP:0000543
13 testicular neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0010788
14 constriction of peripheral visual field 58 31 occasional (7.5%) Occasional (29-5%) HP:0001133
15 uterine neoplasm 58 31 occasional (7.5%) Occasional (29-5%) HP:0010784
16 thymoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0100522
17 hodgkin lymphoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0012189
18 diffuse cerebellar atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0100275
19 central scotoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0000603
20 retinal pigment epithelial atrophy 58 31 occasional (7.5%) Occasional (29-5%) HP:0007722
21 dyschromatopsia 58 31 occasional (7.5%) Occasional (29-5%) HP:0007641
22 paracentral scotoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0030528
23 granular macular appearance 58 31 occasional (7.5%) Occasional (29-5%) HP:0007793
24 foveal hyporeflective spaces on macular oct 58 31 occasional (7.5%) Occasional (29-5%) HP:0030627
25 optic atrophy 58 31 very rare (1%) Very rare (<4-1%) HP:0000648
26 colon cancer 58 31 very rare (1%) Very rare (<4-1%) HP:0003003
27 pancreatic adenocarcinoma 58 31 very rare (1%) Very rare (<4-1%) HP:0006725
28 cutaneous melanoma 58 31 very rare (1%) Very rare (<4-1%) HP:0012056
29 visual hallucinations 58 31 very rare (1%) Very rare (<4-1%) HP:0002367
30 vitritis 58 31 very rare (1%) Very rare (<4-1%) HP:0011531
31 prostate cancer 58 31 very rare (1%) Very rare (<4-1%) HP:0012125
32 neoplasm of the pancreas 58 Very rare (<4-1%)
33 hematological neoplasm 58 Occasional (29-5%)
34 retinal atrophy 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Cancer-Associated Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.61 AIP ENO1 ENO2 FLT1 PGF PTBP2
2 vision/eye MP:0005391 9.17 FLT1 PGF RCVRN RHO SAG TULP1

Drugs & Therapeutics for Cancer-Associated Retinopathy

Search Clinical Trials , NIH Clinical Center for Cancer-Associated Retinopathy

Genetic Tests for Cancer-Associated Retinopathy

Anatomical Context for Cancer-Associated Retinopathy

MalaCards organs/tissues related to Cancer-Associated Retinopathy:

40
Eye, Lung, Colon, Prostate, Breast, Retina, Pancreas

Publications for Cancer-Associated Retinopathy

Articles related to Cancer-Associated Retinopathy:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Presumed cancer-associated retinopathy (CAR) mimicking Sudden Acquired Retinal Degeneration Syndrome (SARDS) in canines. 61
33369040 2021
2
Carcinoma -associated Retinopathy(CAR): Role of Electroretinography(ERG) and Optical coherence Tomography(OCT) in diagnosis and predicting treatment outcome. 61
33511304 2021
3
Cancer-Associated Retinopathy due to Clear Cell Renal Carcinoma. 61
33796514 2021
4
[Subacute, rapidly evolving paraneoplastic retinopathy of unusual severity]. 61
33494973 2021
5
Unique and progressive retinal degeneration in a patient with cancer associated retinopathy. 61
33251374 2020
6
Cancer-associated retinopathy preceding the diagnosis of a pulmonary carcinoid tumour. 61
33139354 2020
7
Ocular Paraneoplastic Syndromes. 61
33182708 2020
8
Clinical Correlation between Acute Exudative Polymorphous Paraneoplastic Vitelliform Maculopathy and Metastatic Melanoma Disease Activity: A 48-month Longitudinal Case Report. 61
33021420 2020
9
Retinal Diseases that Can Masquerade as Neurological Causes of Vision Loss. 61
32930896 2020
10
[A case of paraneoplastic myelopathy associated with anti-CV2/CRMP5 antibodies with small-cell lung cancer]. 61
32641628 2020
11
Testicular Seminoma Presenting with Bilateral Blindness: Looking Beyond the Eye. 61
32377482 2020
12
Masqueraders of multiple evanescent white dot syndrome (MEWDS). 61
31792848 2020
13
Current Techniques to Accurately Measure Anti-retinal Autoantibodies. 61
32318114 2020
14
Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy. 61
31770612 2020
15
Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target. 61
33584813 2020
16
CLINICAL COURSE OF PARANEOPLASTIC RETINOPATHY WITH ANTI-TRPM1 AUTOANTIBODY IN JAPANESE COHORT. 61
30260920 2019
17
Cancer-associated Retinopathy with Neuroendocrine Combined Large-cell Lung Carcinoma and Adenocarcinoma. 61
31327819 2019
18
Cancer-Associated Retinopathy and Treatment with Intravenous Immunoglobulin Therapy. A Seldom Used Approach? 61
31710513 2019
19
Cancer-associated retinopathy in ampullary pancreatic cancer. 61
31712238 2019
20
Complement Proteins in the Retina in Cancer-Associated Retinopathy. 61
31670788 2019
21
Detection of serum anti-retinal antibodies in the Chinese patients with presumed autoimmune retinopathy. 61
31119427 2019
22
A case report of acute zonal occult outer retinopathy. 61
31282209 2019
23
[Recurrent ataxia and respiratory failure with probable paraneoplastic syndrome responsive to plasma exchange therapy]. 61
31142706 2019
24
Case Series of Cancer-associated Retinopathy (CAR). 61
31417817 2019
25
Intravitreal Dexamethasone Implant with Plasma Autoantibody Monitoring for Cancer-associated Retinopathy. 61
31179664 2019
26
[Cancer-associated retinopathy (CAR) in neuroendocrine carcinoma of the uterus]. 61
29931395 2019
27
A blind spot in urology: Prostate cancer associated retinopathy. 61
31211081 2019
28
A case of cancer-associated retinopathy with chorioretinitis and optic neuritis associated with occult small cell lung cancer. 61
31046716 2019
29
Retinochoroidal findings and lung cancer: first report in mexican population. 61
30658928 2019
30
Cancer-associated Retinopathy Developing After 10 Years of Complete Breast Cancer Remission. 61
30723523 2019
31
Wide-field fundus autofluorescence imaging in patients with hereditary retinal degeneration: a literature review. 61
31890285 2019
32
Cancer-associated retinopathy preceding the diagnosis of cancer. 61
30390655 2018
33
Immunopathogenesis of ophthalmological paraneoplastic syndromes: Recent findings. 61
30289210 2018
34
[Paraneoplastic Syndromes in Ophthalmology (French version of the article)]. 61
29891101 2018
35
Seeing is believing: A review of apheresis therapy in the treatment of ophthalmologic disease. 61
29150864 2018
36
Paraneoplastic syndromes in ophthalmology. 61
29784239 2018
37
REVERSIBLE NYCTALOPIA ASSOCIATED WITH VITAMIN A DEFICIENCY AFTER RESECTED MALIGNANT ILEAL CARCINOID AND PANCREATIC ADENOCARCINOMA. 61
29554055 2018
38
In Vivo Adaptive Optics Ophthalmoscopy Correlated with Histopathologic Results in Cancer-Associated Retinopathy. 61
31047341 2018
39
Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies? 61
29713325 2018
40
Idiopathic Acute Exudative Polymorphous Vitelliform Maculopathy: Clinical Spectrum and Multimodal Imaging Characteristics. 61
28844323 2018
41
Cancer-associated retinopathy after surgery for breast cancer: a case report and review of the literature. 61
29362998 2018
42
Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. 61
29260107 2017
43
Unilateral cancer-associated retinopathy: diagnosis, serology and treatment. 61
28815346 2017
44
Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy. 61
28382556 2017
45
Normal-Tension Glaucoma Masqueraders: Detection Using Optical Coherence Tomography. 61
28121717 2017
46
Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy. 61
29503967 2017
47
Retinitis Pigmentosa and Other Dystrophies. 61
28351048 2017
48
Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders. 61
28503176 2017
49
Express of concern on 'Antirecoverin autoantibodies in the patient with non-small cell lung cancer but without cancer-associated retinopathy'. 61
27597142 2016
50
Thyroid malignancy presenting with visual loss: an unusual case of paraneoplastic retinopathy. 61
27797800 2016

Variations for Cancer-Associated Retinopathy

Expression for Cancer-Associated Retinopathy

Search GEO for disease gene expression data for Cancer-Associated Retinopathy.

Pathways for Cancer-Associated Retinopathy

GO Terms for Cancer-Associated Retinopathy

Cellular components related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.96 VEGFA TULP1 SAG RHO RCVRN PGF
2 photoreceptor outer segment GO:0001750 9.26 TULP1 SAG RHO RCVRN
3 phosphopyruvate hydratase complex GO:0000015 9.16 ENO2 ENO1
4 photoreceptor inner segment GO:0001917 9.02 TULP1 SAG RHO RCVRN ENO2

Biological processes related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 VEGFA PGF FLT1
2 visual perception GO:0007601 9.69 TULP1 RHO RCVRN
3 positive regulation of angiogenesis GO:0045766 9.61 VEGFA PGF FLT1
4 glycolytic process GO:0006096 9.55 ENO2 ENO1
5 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 VEGFA FLT1
6 sprouting angiogenesis GO:0002040 9.52 VEGFA PGF
7 phototransduction GO:0007602 9.49 RHO RCVRN
8 canonical glycolysis GO:0061621 9.48 ENO2 ENO1
9 regulation of rhodopsin mediated signaling pathway GO:0022400 9.46 SAG RHO
10 eye photoreceptor cell development GO:0042462 9.4 VEGFA TULP1
11 induction of positive chemotaxis GO:0050930 9.37 VEGFA PGF
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.33 VEGFA PGF FLT1
13 rhodopsin mediated signaling pathway GO:0016056 9.32 SAG RHO
14 positive regulation of mast cell chemotaxis GO:0060754 9.26 VEGFA PGF
15 regulation of vacuole fusion, non-autophagic GO:0032889 8.96 ENO2 ENO1
16 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFA PGF FLT1

Molecular functions related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 VEGFA PGF
2 vascular endothelial growth factor receptor binding GO:0005172 8.96 VEGFA PGF
3 phosphopyruvate hydratase activity GO:0004634 8.62 ENO2 ENO1

Sources for Cancer-Associated Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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