MCID: CNC014
MIFTS: 38

Cancer-Associated Retinopathy

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cancer-Associated Retinopathy

MalaCards integrated aliases for Cancer-Associated Retinopathy:

Name: Cancer-Associated Retinopathy 59 73
Paraneoplastic Retinopathy 59 73
Car Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
cancer-associated retinopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA71505
UMLS via Orphanet 74 C0730307 C1321315
ICD10 33 Z50.9

Summaries for Cancer-Associated Retinopathy

MalaCards based summary : Cancer-Associated Retinopathy, also known as paraneoplastic retinopathy, is related to autoimmune retinopathy and retinal degeneration. An important gene associated with Cancer-Associated Retinopathy is RCVRN (Recoverin), and among its related pathways/superpathways are Focal Adhesion and Metabolism of fat-soluble vitamins. Affiliated tissues include lung, eye and breast, and related phenotypes are nervous system and vision/eye

Related Diseases for Cancer-Associated Retinopathy

Diseases related to Cancer-Associated Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 autoimmune retinopathy 32.6 ENO1 ENO2
2 retinal degeneration 29.5 RHO SAG TULP1
3 retinal disease 29.5 RHO SAG TULP1
4 macular degeneration, age-related, 1 29.4 FLT1 PGF RHO VEGFA
5 lung cancer 10.3
6 small cell cancer of the lung 10.2
7 melanoma 10.2
8 lymphocytic hypophysitis 10.2 ENO1 ENO2
9 retinitis pigmentosa 14 10.1 ENO1 TULP1
10 neuroretinitis 10.1 RCVRN VEGFA
11 large cell carcinoma with rhabdoid phenotype 10.1 ENO2 VEGFA
12 optic disk drusen 10.1 RHO VEGFA
13 brain injury 10.1 ENO1 ENO2
14 angiokeratoma circumscriptum 10.1 FLT1 VEGFA
15 glomeruloid hemangioma 10.1 FLT1 VEGFA
16 skin hemangioma 10.1 FLT1 VEGFA
17 mild pre-eclampsia 10.1 FLT1 PGF
18 skin melanoma 10.1
19 twin-to-twin transfusion syndrome 10.1 FLT1 PGF
20 capillary hemangioma 10.1 FLT1 VEGFA
21 carcinoid syndrome 10.1 ENO2 VEGFA
22 lipodermatosclerosis 10.1 FLT1 VEGFA
23 coats disease 10.1 RHO VEGFA
24 placenta accreta 10.1 FLT1 PGF
25 tuberculous meningitis 10.1 ENO2 VEGFA
26 yemenite deaf-blind hypopigmentation syndrome 10.1 RHO VEGFA
27 retinal hemangioblastoma 10.1 ENO2 VEGFA
28 neovascular glaucoma 10.1 PGF VEGFA
29 kuhnt-junius degeneration 10.0 PGF VEGFA
30 degeneration of macula and posterior pole 10.0 RHO VEGFA
31 retinal vascular occlusion 10.0 PGF VEGFA
32 melanoma-associated retinopathy 10.0 RHO SAG
33 optic nerve disease 10.0
34 neuropathy 10.0
35 placental abruption 10.0 FLT1 PGF
36 patellar tendinitis 10.0 PTBP2 VEGFA
37 pituitary tumors 10.0 AIP VEGFA
38 bardet-biedl syndrome 5 10.0 RHO SAG
39 pineal gland cancer 10.0 ENO2 SAG
40 nervous system disease 10.0 ENO2 RHO VEGFA
41 autoimmune disease of eyes, ear, nose and throat 10.0 RHO SAG
42 papillary ependymoma 10.0 ENO2 SAG
43 vascular cancer 10.0 FLT1 VEGFA
44 oguchi disease 10.0 RHO SAG
45 microcystic meningioma 10.0 ENO2 FLT1 VEGFA
46 ovarian cancer 10.0
47 endometrial cancer 10.0
48 small cell carcinoma 10.0
49 thymoma 10.0
50 vasculitis 10.0

Graphical network of the top 20 diseases related to Cancer-Associated Retinopathy:



Diseases related to Cancer-Associated Retinopathy

Symptoms & Phenotypes for Cancer-Associated Retinopathy

MGI Mouse Phenotypes related to Cancer-Associated Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 ENO2 FLT1 PTBP2 RHO SAG TULP1
2 vision/eye MP:0005391 9.17 FLT1 PGF RCVRN RHO SAG TULP1

Drugs & Therapeutics for Cancer-Associated Retinopathy

Search Clinical Trials , NIH Clinical Center for Cancer-Associated Retinopathy

Genetic Tests for Cancer-Associated Retinopathy

Anatomical Context for Cancer-Associated Retinopathy

MalaCards organs/tissues related to Cancer-Associated Retinopathy:

41
Lung, Eye, Breast, Skin, Brain, Pineal, Placenta

Publications for Cancer-Associated Retinopathy

Articles related to Cancer-Associated Retinopathy:

(show top 50) (show all 127)
# Title Authors Year
1
Cancer-associated retinopathy after surgery for breast cancer: a case report and review of the literature. ( 29362998 )
2018
2
Cancer-associated retinopathy preceding the diagnosis of cancer. ( 30390655 )
2018
3
CLINICAL COURSE OF PARANEOPLASTIC RETINOPATHY WITH ANTI-TRPM1 AUTOANTIBODY IN JAPANESE COHORT. ( 30260920 )
2018
4
Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy. ( 29503967 )
2017
5
Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. ( 29260107 )
2017
6
Unilateral cancer-associated retinopathy: diagnosis, serology and treatment. ( 28815346 )
2017
7
Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy. ( 28382556 )
2017
8
GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy. ( 27152249 )
2016
9
Cancer-associated retinopathy as the leading symptom in colon cancer. ( 26862417 )
2016
10
Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. ( 27185162 )
2016
11
Aryl Hydrocarbon Receptor-Interacting Protein-Like 1 in Cancer-Associated Retinopathy. ( 26854037 )
2016
12
Paraneoplastic retinopathy associated with occult bladder cancer. ( 27146943 )
2016
13
Thyroid malignancy presenting with visual loss: an unusual case of paraneoplastic retinopathy. ( 27797800 )
2016
14
Unilateral cancer-associated retinopathy: a case report. ( 26246524 )
2015
15
Retinal imaging with en face and cross-sectional optical coherence tomography delineates outer retinal changes in cancer-associated retinopathy secondary to Merkel cell carcinoma. ( 26285790 )
2015
16
Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. ( 25468200 )
2015
17
Large cell neuroendocrine carcinoma of the lung with cancer-associated retinopathy. ( 25873883 )
2015
18
Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs. ( 25391361 )
2015
19
Paraneoplastic retinopathy associated with systemic follicular cell lymphoma. ( 25835308 )
2015
20
CANCER-ASSOCIATED RETINOPATHY WITH UNUSUAL RETINAL WHITENING. ( 25383855 )
2014
21
Cystoid macular edema from cancer-associated retinopathy. ( 24531653 )
2014
22
Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody. ( 24523577 )
2014
23
Cancer associated retinopathy with periphlebitis and bilateral vitreous hemorrhage. ( 24923085 )
2013
24
Intravenous rituximab for the treatment of cancer-associated retinopathy. ( 23561621 )
2013
25
Treatment of cancer-associated retinopathy with rituximab. ( 24225966 )
2013
26
Significance of Anti-retinal Autoantibodies in Cancer-associated Retinopathy with Gynecological Cancers. ( 24672741 )
2013
27
Clinical and immunological characterization of paraneoplastic retinopathy. ( 23860756 )
2013
28
Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy. ( 24282602 )
2013
29
Cancer-associated retinopathy in a patient with seminoma. ( 25390951 )
2012
30
Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy. ( 22415770 )
2012
31
Cancer-associated retinopathy presenting as retinal vasculitis with a negative ERG suggestive of on-bipolar cell pathway dysfunction. ( 21674222 )
2011
32
Two cases of cancer-associated retinopathy combined with small-cell lung cancer. ( 21385760 )
2011
33
Cancer-associated retinopathy: update on pathogenesis and therapy. ( 21958182 )
2011
34
Clear cell carcinoma of the endometrium causing paraneoplastic retinopathy: case report and review of the literature. ( 22567514 )
2011
35
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. ( 20724944 )
2010
36
Cancer-associated retinopathy with retinal periphlebitis in a patient with ovarian cancer. ( 20370338 )
2010
37
Cancer-associated retinopathy caused by benign thymoma. ( 20424218 )
2010
38
Choroidal neovascularization associated with cancer-associated retinopathy. ( 19141145 )
2010
39
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. ( 20080765 )
2010
40
Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling. ( 20473029 )
2010
41
Paraneoplastic retinopathy with multiple detachments of the neurosensory retina and autoantibodies against interphotoreceptor retinoid binding protein (IRBP) in cutaneous melanoma. ( 19286685 )
2010
42
Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. ( 19168157 )
2009
43
Antibodies to 46-kDa retinal antigen in a patient with breast carcinoma and cancer-associated retinopathy. ( 17851760 )
2008
44
Cancer-associated retinopathy (CAR) with electronegative ERG: a case report. ( 17721792 )
2008
45
Fifteen-year follow-up of patient with cancer-associated retinopathy. ( 17295149 )
2007
46
Cancer-associated retinopathy in a child with Langerhans cell histiocytosis. ( 17926119 )
2007
47
Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy. ( 17397962 )
2007
48
Cancer-associated retinopathy in patients with breast carcinoma. ( 17659379 )
2007
49
Slowly progressive cancer-associated retinopathy. ( 17923561 )
2007
50
Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy. ( 17374419 )
2007

Variations for Cancer-Associated Retinopathy

Expression for Cancer-Associated Retinopathy

Search GEO for disease gene expression data for Cancer-Associated Retinopathy.

Pathways for Cancer-Associated Retinopathy

Pathways related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 FLT1 PGF RHO VEGFA
2
Show member pathways
11.98 RCVRN RHO SAG
3
Show member pathways
11.74 RCVRN RHO SAG
4 11.41 RCVRN RHO SAG
5
Show member pathways
11.3 FLT1 PGF VEGFA
6 11.26 ENO1 ENO2 FLT1 VEGFA
7 11.21 AIP VEGFA
8 11.13 FLT1 VEGFA
9 11.03 FLT1 VEGFA
10 10.86 RCVRN RHO SAG
11 10.85 FLT1 VEGFA
12 10.78 FLT1 VEGFA
13
Show member pathways
10 FLT1 PGF VEGFA

GO Terms for Cancer-Associated Retinopathy

Cellular components related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 9.33 RHO SAG TULP1
2 phosphopyruvate hydratase complex GO:0000015 8.96 ENO1 ENO2
3 photoreceptor inner segment GO:0001917 8.92 ENO2 RHO SAG TULP1

Biological processes related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.74 FLT1 PGF VEGFA
2 visual perception GO:0007601 9.67 RCVRN RHO TULP1
3 positive regulation of angiogenesis GO:0045766 9.61 FLT1 PGF VEGFA
4 positive chemotaxis GO:0050918 9.59 PGF VEGFA
5 positive regulation of cell division GO:0051781 9.58 PGF VEGFA
6 gluconeogenesis GO:0006094 9.58 ENO1 ENO2
7 glycolytic process GO:0006096 9.56 ENO1 ENO2
8 photoreceptor cell maintenance GO:0045494 9.55 RHO TULP1
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 FLT1 VEGFA
10 phototransduction GO:0007602 9.52 RCVRN RHO
11 sprouting angiogenesis GO:0002040 9.51 PGF VEGFA
12 canonical glycolysis GO:0061621 9.48 ENO1 ENO2
13 regulation of rhodopsin mediated signaling pathway GO:0022400 9.46 RHO SAG
14 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.4 FLT1 VEGFA
15 eye photoreceptor cell development GO:0042462 9.37 TULP1 VEGFA
16 induction of positive chemotaxis GO:0050930 9.32 PGF VEGFA
17 rhodopsin mediated signaling pathway GO:0016056 9.26 RHO SAG
18 positive regulation of mast cell chemotaxis GO:0060754 9.16 PGF VEGFA
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.13 FLT1 PGF VEGFA
20 vascular endothelial growth factor signaling pathway GO:0038084 8.8 FLT1 PGF VEGFA

Molecular functions related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 9.16 PGF VEGFA
2 vascular endothelial growth factor receptor 3 binding GO:0043185 8.96 PGF VEGFA
3 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2

Sources for Cancer-Associated Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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