MCID: CNC014
MIFTS: 36

Cancer-Associated Retinopathy

Categories: Neuronal diseases, Eye diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Cancer-Associated Retinopathy

MalaCards integrated aliases for Cancer-Associated Retinopathy:

Name: Cancer-Associated Retinopathy 59 73
Paraneoplastic Retinopathy 59 73
Car Syndrome 59

Characteristics:

Orphanet epidemiological data:

59
cancer-associated retinopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA71505
UMLS via Orphanet 74 C0730307 C1321315
ICD10 33 Z50.9

Summaries for Cancer-Associated Retinopathy

MalaCards based summary : Cancer-Associated Retinopathy, also known as paraneoplastic retinopathy, is related to autoimmune retinopathy and retinal degeneration. An important gene associated with Cancer-Associated Retinopathy is RCVRN (Recoverin), and among its related pathways/superpathways are Focal Adhesion and Metabolism of fat-soluble vitamins. Affiliated tissues include lung, eye and breast, and related phenotype is vision/eye.

Related Diseases for Cancer-Associated Retinopathy

Diseases related to Cancer-Associated Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 autoimmune retinopathy 32.3 ENO1 ENO2
2 retinal degeneration 29.5 RHO SAG TULP1
3 retinal disease 29.4 RHO SAG TULP1
4 macular degeneration, age-related, 1 28.9 FLT1 PGF RHO VEGFA
5 retinitis pigmentosa 14 10.6 ENO1 TULP1
6 mild pre-eclampsia 10.4 FLT1 PGF
7 twin-to-twin transfusion syndrome 10.4 FLT1 PGF
8 placenta accreta 10.4 FLT1 PGF
9 neovascular glaucoma 10.4 PGF VEGFA
10 retinitis 10.4
11 kuhnt-junius degeneration 10.3 PGF VEGFA
12 melanoma-associated retinopathy 10.3 RHO SAG
13 yemenite deaf-blind hypopigmentation syndrome 10.3 RHO VEGFA
14 retinal vascular occlusion 10.3 PGF VEGFA
15 bardet-biedl syndrome 5 10.3 RHO SAG
16 angiokeratoma circumscriptum 10.3 FLT1 VEGFA
17 neuroretinitis 10.3 RCVRN VEGFA
18 hereditary night blindness 10.3 RHO SAG
19 glomeruloid hemangioma 10.3 FLT1 VEGFA
20 coats disease 10.2 RHO VEGFA
21 lipodermatosclerosis 10.2 FLT1 VEGFA
22 acute hemorrhagic leukoencephalitis 10.2 FLT1 VEGFA
23 lung cancer 10.2
24 peripartum cardiomyopathy 10.1 FLT1 VEGFA
25 small cell cancer of the lung 10.1
26 placental abruption 10.1 FLT1 PGF
27 lymphocytic hypophysitis 10.1 ENO1 ENO2
28 eales disease 9.9 SAG VEGFA
29 purulent endophthalmitis 9.9 SAG VEGFA
30 epithelioid hemangioendothelioma 9.9 FLT1 PGF VEGFA
31 placental insufficiency 9.9 FLT1 PGF VEGFA
32 microvascular complications of diabetes 5 9.9 FLT1 PGF VEGFA
33 endometrial cancer 9.9
34 small cell carcinoma 9.9
35 vasculitis 9.9
36 ovarian cancer 9.9
37 paraneoplastic syndromes 9.9
38 thymoma 9.9
39 vascular cancer 9.9 FLT1 VEGFA
40 degeneration of macula and posterior pole 9.8 RHO VEGFA
41 large cell carcinoma with rhabdoid phenotype 9.8 ENO2 VEGFA
42 neuropathy 9.8
43 optic nerve disease 9.8
44 carcinoid syndrome 9.7 ENO2 VEGFA
45 ovarian cancer 1 9.7
46 merkel cell carcinoma 9.7
47 seminoma 9.7
48 macular retinal edema 9.7
49 retinal cancer 9.7
50 large cell neuroendocrine carcinoma 9.7

Graphical network of the top 20 diseases related to Cancer-Associated Retinopathy:



Diseases related to Cancer-Associated Retinopathy

Symptoms & Phenotypes for Cancer-Associated Retinopathy

MGI Mouse Phenotypes related to Cancer-Associated Retinopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.17 FLT1 PGF RCVRN RHO SAG TULP1

Drugs & Therapeutics for Cancer-Associated Retinopathy

Search Clinical Trials , NIH Clinical Center for Cancer-Associated Retinopathy

Genetic Tests for Cancer-Associated Retinopathy

Anatomical Context for Cancer-Associated Retinopathy

MalaCards organs/tissues related to Cancer-Associated Retinopathy:

41
Lung, Eye, Breast, Retina, Colon

Publications for Cancer-Associated Retinopathy

Articles related to Cancer-Associated Retinopathy:

(show top 50) (show all 96)
# Title Authors Year
1
Cancer-associated retinopathy after surgery for breast cancer: a case report and review of the literature. ( 29362998 )
2018
2
Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy. ( 29503967 )
2017
3
Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. ( 29260107 )
2017
4
Unilateral cancer-associated retinopathy: diagnosis, serology and treatment. ( 28815346 )
2017
5
GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy. ( 27152249 )
2016
6
Cancer-associated retinopathy as the leading symptom in colon cancer. ( 26862417 )
2016
7
Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. ( 27185162 )
2016
8
Aryl Hydrocarbon Receptor-Interacting Protein-Like 1 in Cancer-Associated Retinopathy. ( 26854037 )
2016
9
Unilateral cancer-associated retinopathy: a case report. ( 26246524 )
2015
10
Retinal imaging with en face and cross-sectional optical coherence tomography delineates outer retinal changes in cancer-associated retinopathy secondary to Merkel cell carcinoma. ( 26285790 )
2015
11
Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. ( 25468200 )
2015
12
Large cell neuroendocrine carcinoma of the lung with cancer-associated retinopathy. ( 25873883 )
2015
13
CANCER-ASSOCIATED RETINOPATHY WITH UNUSUAL RETINAL WHITENING. ( 25383855 )
2014
14
Cystoid macular edema from cancer-associated retinopathy. ( 24531653 )
2014
15
Cancer associated retinopathy with periphlebitis and bilateral vitreous hemorrhage. ( 24923085 )
2013
16
Intravenous rituximab for the treatment of cancer-associated retinopathy. ( 23561621 )
2013
17
Treatment of cancer-associated retinopathy with rituximab. ( 24225966 )
2013
18
Significance of Anti-retinal Autoantibodies in Cancer-associated Retinopathy with Gynecological Cancers. ( 24672741 )
2013
19
Cancer-associated retinopathy in a patient with seminoma. ( 25390951 )
2012
20
Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy. ( 22415770 )
2012
21
Cancer-associated retinopathy presenting as retinal vasculitis with a negative ERG suggestive of on-bipolar cell pathway dysfunction. ( 21674222 )
2011
22
Two cases of cancer-associated retinopathy combined with small-cell lung cancer. ( 21385760 )
2011
23
Cancer-associated retinopathy: update on pathogenesis and therapy. ( 21958182 )
2011
24
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. ( 20724944 )
2010
25
Cancer-associated retinopathy with retinal periphlebitis in a patient with ovarian cancer. ( 20370338 )
2010
26
Cancer-associated retinopathy caused by benign thymoma. ( 20424218 )
2010
27
Choroidal neovascularization associated with cancer-associated retinopathy. ( 19141145 )
2010
28
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. ( 20080765 )
2010
29
Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling. ( 20473029 )
2010
30
Antibodies to 46-kDa retinal antigen in a patient with breast carcinoma and cancer-associated retinopathy. ( 17851760 )
2008
31
Cancer-associated retinopathy (CAR) with electronegative ERG: a case report. ( 17721792 )
2008
32
Fifteen-year follow-up of patient with cancer-associated retinopathy. ( 17295149 )
2007
33
Cancer-associated retinopathy in a child with Langerhans cell histiocytosis. ( 17926119 )
2007
34
Long-term survival of a patient with small cell lung cancer associated with cancer-associated retinopathy. ( 17397962 )
2007
35
Cancer-associated retinopathy in patients with breast carcinoma. ( 17659379 )
2007
36
Slowly progressive cancer-associated retinopathy. ( 17923561 )
2007
37
Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy. ( 17374419 )
2007
38
Successful treatment of cancer-associated retinopathy with alemtuzumab. ( 17252185 )
2007
39
Acute optical coherence tomographic findings in cancer-associated retinopathy. ( 17698766 )
2007
40
Effects of cytotoxic T lymphocyte antigen 4 (CTLA4) signaling and locally applied steroid on retinal dysfunction by recoverin, cancer-associated retinopathy antigen. ( 16917481 )
2006
41
Evaluation of a comparative pathogenesis between cancer-associated retinopathy in humans and sudden acquired retinal degeneration syndrome in dogs via diagnostic imaging and western blot analysis. ( 16649924 )
2006
42
Cancer associated retinopathy (CAR): An autoimmune-mediated paraneoplastic syndrome. ( 16912011 )
2006
43
[Small cell lung cancer and cancer-associated retinopathy]. ( 15718005 )
2005
44
Cancer-associated retinopathy in a patient with hepatocellular carcinoma: case report and literature review. ( 16340542 )
2005
45
Bilateral diffuse uveal melanocytic proliferation in a patient with cancer-associated retinopathy. ( 16310487 )
2005
46
Anti-alpha-enolase antibodies in cancer-associated retinopathy with small cell carcinoma of the lung. ( 15808190 )
2005
47
Clinical and immunologic aspects of cancer-associated retinopathy. ( 15183799 )
2004
48
Antirecoverin autoantibodies in the patient with non-small cell lung cancer but without cancer-associated retinopathy. ( 12928127 )
2003
49
Vaccination with recoverin, a cancer-associated retinopathy antigen, induces autoimmune retinal dysfunction and tumor cell regression in mice. ( 12209643 )
2002
50
Pathological roles of recoverin in cancer-associated retinopathy. ( 12596918 )
2002

Variations for Cancer-Associated Retinopathy

Expression for Cancer-Associated Retinopathy

Search GEO for disease gene expression data for Cancer-Associated Retinopathy.

Pathways for Cancer-Associated Retinopathy

GO Terms for Cancer-Associated Retinopathy

Cellular components related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 9.33 RHO SAG TULP1
2 phosphopyruvate hydratase complex GO:0000015 8.96 ENO1 ENO2
3 photoreceptor inner segment GO:0001917 8.92 ENO2 RHO SAG TULP1

Biological processes related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.73 FLT1 PGF VEGFA
2 visual perception GO:0007601 9.7 RCVRN RHO TULP1
3 positive regulation of angiogenesis GO:0045766 9.58 FLT1 PGF VEGFA
4 glycolytic process GO:0006096 9.55 ENO1 ENO2
5 photoreceptor cell maintenance GO:0045494 9.54 RHO TULP1
6 phototransduction GO:0007602 9.51 RCVRN RHO
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.49 FLT1 VEGFA
8 sprouting angiogenesis GO:0002040 9.48 FLT1 PGF
9 canonical glycolysis GO:0061621 9.46 ENO1 ENO2
10 regulation of rhodopsin mediated signaling pathway GO:0022400 9.43 RHO SAG
11 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.37 FLT1 VEGFA
12 eye photoreceptor cell development GO:0042462 9.32 TULP1 VEGFA
13 induction of positive chemotaxis GO:0050930 9.26 PGF VEGFA
14 rhodopsin mediated signaling pathway GO:0016056 9.16 RHO SAG
15 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.13 FLT1 PGF VEGFA
16 positive regulation of mast cell chemotaxis GO:0060754 8.62 PGF VEGFA

Molecular functions related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor receptor binding GO:0005172 8.96 PGF VEGFA
2 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2

Sources for Cancer-Associated Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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