MCID: CNC014
MIFTS: 38

Cancer-Associated Retinopathy

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cancer-Associated Retinopathy

MalaCards integrated aliases for Cancer-Associated Retinopathy:

Name: Cancer-Associated Retinopathy 60 74
Paraneoplastic Retinopathy 60 74
Car Syndrome 60

Characteristics:

Orphanet epidemiological data:

60
cancer-associated retinopathy
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

ICD10 34 Z50.9
UMLS via Orphanet 75 C0730307 C1321315
Orphanet 60 ORPHA71505

Summaries for Cancer-Associated Retinopathy

MalaCards based summary : Cancer-Associated Retinopathy, also known as paraneoplastic retinopathy, is related to autoimmune retinopathy and macular degeneration, age-related, 1. An important gene associated with Cancer-Associated Retinopathy is RCVRN (Recoverin), and among its related pathways/superpathways are Focal Adhesion and Metabolism of fat-soluble vitamins. Affiliated tissues include lung, breast and eye, and related phenotypes are nervous system and vision/eye

Related Diseases for Cancer-Associated Retinopathy

Diseases related to Cancer-Associated Retinopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 autoimmune retinopathy 32.8 ENO1 ENO2
2 macular degeneration, age-related, 1 29.3 FLT1 PGF RHO VEGFA
3 retinal degeneration 29.3 RHO SAG TULP1
4 retinal disease 29.2 RHO SAG TULP1
5 paraneoplastic syndromes 10.4 RCVRN RHO
6 lung cancer 10.3
7 lymphocytic hypophysitis 10.3 ENO1 ENO2
8 small cell cancer of the lung 10.3
9 melanoma 10.3
10 neuroretinitis 10.2 RCVRN VEGFA
11 angiokeratoma circumscriptum 10.2 FLT1 VEGFA
12 optic disk drusen 10.2 RHO VEGFA
13 glomeruloid hemangioma 10.2 FLT1 VEGFA
14 skin hemangioma 10.2 FLT1 VEGFA
15 large cell carcinoma with rhabdoid phenotype 10.2 ENO2 VEGFA
16 mild pre-eclampsia 10.2 FLT1 PGF
17 brain injury 10.2 ENO1 ENO2
18 melanoma-associated retinopathy 10.2 RHO SAG
19 twin-to-twin transfusion syndrome 10.2 FLT1 PGF
20 capillary hemangioma 10.2 FLT1 VEGFA
21 lipodermatosclerosis 10.2 FLT1 VEGFA
22 placenta accreta 10.1 FLT1 PGF
23 bardet-biedl syndrome 5 10.1 RHO SAG
24 coats disease 10.1 RHO VEGFA
25 patellar tendinitis 10.1 PTBP2 VEGFA
26 breast cancer 10.1
27 carcinoid syndrome 10.1 ENO2 VEGFA
28 skin melanoma 10.1
29 yemenite deaf-blind hypopigmentation syndrome 10.1 RHO VEGFA
30 autoimmune disease of eyes, ear, nose and throat 10.1 RHO SAG
31 pineal gland cancer 10.1 ENO2 SAG
32 tuberculous meningitis 10.1 ENO2 VEGFA
33 oguchi disease 10.1 RHO SAG
34 neovascular glaucoma 10.1 PGF VEGFA
35 degeneration of macula and posterior pole 10.1 RHO VEGFA
36 kuhnt-junius degeneration 10.1 PGF VEGFA
37 papillary ependymoma 10.1 ENO2 SAG
38 retinal hemangioblastoma 10.1 ENO2 VEGFA
39 placental abruption 10.1 FLT1 PGF
40 retinal vascular occlusion 10.1 PGF VEGFA
41 pituitary tumors 10.1 AIP VEGFA
42 optic nerve disease 10.0
43 neuropathy 10.0
44 cerebellar liponeurocytoma 10.0 ENO2 SAG
45 medullomyoblastoma 10.0 ENO2 SAG
46 vascular cancer 10.0 FLT1 VEGFA
47 retinitis pigmentosa 14 10.0 ENO1 TULP1
48 breast carcinoma in situ 10.0 FLT1 VEGFA
49 eales disease 10.0 SAG VEGFA
50 carney complex, type 1 10.0

Graphical network of the top 20 diseases related to Cancer-Associated Retinopathy:



Diseases related to Cancer-Associated Retinopathy

Symptoms & Phenotypes for Cancer-Associated Retinopathy

MGI Mouse Phenotypes related to Cancer-Associated Retinopathy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 ENO2 FLT1 PTBP2 RHO SAG TULP1
2 vision/eye MP:0005391 9.17 FLT1 PGF RCVRN RHO SAG TULP1

Drugs & Therapeutics for Cancer-Associated Retinopathy

Search Clinical Trials , NIH Clinical Center for Cancer-Associated Retinopathy

Genetic Tests for Cancer-Associated Retinopathy

Anatomical Context for Cancer-Associated Retinopathy

MalaCards organs/tissues related to Cancer-Associated Retinopathy:

42
Lung, Breast, Eye, Skin, Pineal, Retina, Colon

Publications for Cancer-Associated Retinopathy

Articles related to Cancer-Associated Retinopathy:

(show top 50) (show all 139)
# Title Authors Year
1
Cancer-associated Retinopathy Developing After 10 Years of Complete Breast Cancer Remission. ( 30723523 )
2019
2
A case of cancer-associated retinopathy with chorioretinitis and optic neuritis associated with occult small cell lung cancer. ( 31046716 )
2019
3
Cancer-associated retinopathy after surgery for breast cancer: a case report and review of the literature. ( 29362998 )
2018
4
Cancer-associated retinopathy preceding the diagnosis of cancer. ( 30390655 )
2018
5
In Vivo Adaptive Optics Ophthalmoscopy Correlated with Histopathologic Results in Cancer-Associated Retinopathy. ( 31047341 )
2018
6
CLINICAL COURSE OF PARANEOPLASTIC RETINOPATHY WITH ANTI-TRPM1 AUTOANTIBODY IN JAPANESE COHORT. ( 30260920 )
2018
7
Unilateral cancer-associated retinopathy: diagnosis, serology and treatment. ( 28815346 )
2017
8
Recovery of outer retinal laminations on optical coherence tomography after treatment of cancer associated retinopathy. ( 29260107 )
2017
9
Improvements of visual function and outer retinal morphology following spontaneous regression of cancer in anti-recoverin cancer-associated retinopathy. ( 29503967 )
2017
10
Acute progressive paravascular placoid neuroretinopathy with negative-type electroretinography in paraneoplastic retinopathy. ( 28382556 )
2017
11
GCAP1, Rab6, and HSP27: Novel Autoantibody Targets in Cancer-Associated Retinopathy and Autoimmune Retinopathy. ( 27152249 )
2016
12
Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. ( 27185162 )
2016
13
Unilateral cancer-associated retinopathy: a case report. ( 26246524 )
2016
14
Aryl Hydrocarbon Receptor-Interacting Protein-Like 1 in Cancer-Associated Retinopathy. ( 26854037 )
2016
15
Cancer-associated retinopathy as the leading symptom in colon cancer. ( 26862417 )
2016
16
Paraneoplastic retinopathy associated with occult bladder cancer. ( 27146943 )
2016
17
Thyroid malignancy presenting with visual loss: an unusual case of paraneoplastic retinopathy. ( 27797800 )
2016
18
Cancer-associated retinopathy with unusual retinal whitening. ( 25383855 )
2015
19
Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy. ( 25468200 )
2015
20
Large cell neuroendocrine carcinoma of the lung with cancer-associated retinopathy. ( 25873883 )
2015
21
Retinal imaging with en face and cross-sectional optical coherence tomography delineates outer retinal changes in cancer-associated retinopathy secondary to Merkel cell carcinoma. ( 26285790 )
2015
22
A Man with Paraneoplastic Retinopathy plus Small Fiber Polyneuropathy Associated with Waldenström Macroglobulinemia (Lymphoplasmacytic Lymphoma): Insights into Mechanisms. ( 24654565 )
2015
23
Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs. ( 25391361 )
2015
24
Paraneoplastic retinopathy associated with systemic follicular cell lymphoma. ( 25835308 )
2015
25
Cystoid macular edema from cancer-associated retinopathy. ( 24531653 )
2014
26
Choroidal atrophy in a patient with paraneoplastic retinopathy and anti-TRPM1 antibody. ( 24523577 )
2014
27
Intravenous rituximab for the treatment of cancer-associated retinopathy. ( 23561621 )
2013
28
Treatment of cancer-associated retinopathy with rituximab. ( 24225966 )
2013
29
Significance of Anti-retinal Autoantibodies in Cancer-associated Retinopathy with Gynecological Cancers. ( 24672741 )
2013
30
Cancer associated retinopathy with periphlebitis and bilateral vitreous hemorrhage. ( 24923085 )
2013
31
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management. ( 23969019 )
2013
32
Clinical and immunological characterization of paraneoplastic retinopathy. ( 23860756 )
2013
33
Degeneration of retinal on bipolar cells induced by serum including autoantibody against TRPM1 in mouse model of paraneoplastic retinopathy. ( 24282602 )
2013
34
Intravitreal triamcinolone for cancer-associated retinopathy refractory to systemic therapy. ( 22415770 )
2012
35
Cancer-associated retinopathy in a patient with seminoma. ( 25390951 )
2012
36
Two cases of cancer-associated retinopathy combined with small-cell lung cancer. ( 21385760 )
2011
37
Cancer-associated retinopathy presenting as retinal vasculitis with a negative ERG suggestive of on-bipolar cell pathway dysfunction. ( 21674222 )
2011
38
Cancer-associated retinopathy: update on pathogenesis and therapy. ( 21958182 )
2011
39
Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction. ( 21611200 )
2011
40
Clear cell carcinoma of the endometrium causing paraneoplastic retinopathy: case report and review of the literature. ( 22567514 )
2011
41
Choroidal neovascularization associated with cancer-associated retinopathy. ( 19141145 )
2010
42
VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy. ( 20080765 )
2010
43
Cancer-associated retinopathy with retinal periphlebitis in a patient with ovarian cancer. ( 20370338 )
2010
44
Cancer-associated retinopathy caused by benign thymoma. ( 20424218 )
2010
45
Cancer-associated retinopathy: a new mechanistic insight on vascular remodeling. ( 20473029 )
2010
46
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. ( 20724944 )
2010
47
Paraneoplastic retinopathy associated with retroperitoneal liposarcoma. ( 20463790 )
2010
48
Paraneoplastic retinopathy with multiple detachments of the neurosensory retina and autoantibodies against interphotoreceptor retinoid binding protein (IRBP) in cutaneous melanoma. ( 19286685 )
2010
49
Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy. ( 19168157 )
2009
50
Cancer-associated retinopathy (CAR) with electronegative ERG: a case report. ( 17721792 )
2008

Variations for Cancer-Associated Retinopathy

Expression for Cancer-Associated Retinopathy

Search GEO for disease gene expression data for Cancer-Associated Retinopathy.

Pathways for Cancer-Associated Retinopathy

GO Terms for Cancer-Associated Retinopathy

Cellular components related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor outer segment GO:0001750 9.33 RHO SAG TULP1
2 phosphopyruvate hydratase complex GO:0000015 8.96 ENO1 ENO2
3 photoreceptor inner segment GO:0001917 8.92 ENO2 RHO SAG TULP1

Biological processes related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.74 FLT1 PGF VEGFA
2 visual perception GO:0007601 9.67 RCVRN RHO TULP1
3 positive regulation of angiogenesis GO:0045766 9.61 FLT1 PGF VEGFA
4 positive chemotaxis GO:0050918 9.59 PGF VEGFA
5 positive regulation of cell division GO:0051781 9.58 PGF VEGFA
6 gluconeogenesis GO:0006094 9.58 ENO1 ENO2
7 glycolytic process GO:0006096 9.56 ENO1 ENO2
8 photoreceptor cell maintenance GO:0045494 9.55 RHO TULP1
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.54 FLT1 VEGFA
10 phototransduction GO:0007602 9.52 RCVRN RHO
11 sprouting angiogenesis GO:0002040 9.51 PGF VEGFA
12 canonical glycolysis GO:0061621 9.48 ENO1 ENO2
13 regulation of rhodopsin mediated signaling pathway GO:0022400 9.46 RHO SAG
14 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.4 FLT1 VEGFA
15 eye photoreceptor cell development GO:0042462 9.37 TULP1 VEGFA
16 induction of positive chemotaxis GO:0050930 9.32 PGF VEGFA
17 rhodopsin mediated signaling pathway GO:0016056 9.26 RHO SAG
18 positive regulation of mast cell chemotaxis GO:0060754 9.16 PGF VEGFA
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.13 FLT1 PGF VEGFA
20 vascular endothelial growth factor signaling pathway GO:0038084 8.8 FLT1 PGF VEGFA

Molecular functions related to Cancer-Associated Retinopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemoattractant activity GO:0042056 8.96 PGF VEGFA
2 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2

Sources for Cancer-Associated Retinopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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