MCID: CNC001
MIFTS: 37

Cancerophobia

Categories: Mental diseases, Cancer diseases

Aliases & Classifications for Cancerophobia

MalaCards integrated aliases for Cancerophobia:

Name: Cancerophobia 12 15 73
Fear of Getting Cancer 12
Cancer Phobia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:602
NCIt 50 C35492
UMLS 73 C0233705

Summaries for Cancerophobia

MalaCards based summary : Cancerophobia, also known as fear of getting cancer, is related to breast medullary carcinoma and papillary serous adenocarcinoma. An important gene associated with Cancerophobia is MCIDAS (Multiciliate Differentiation And DNA Synthesis Associated Cell Cycle Protein), and among its related pathways/superpathways are Homologous DNA Pairing and Strand Exchange and Cell cycle Role of SCF complex in cell cycle regulation. The drugs Anastrozole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and bone, and related phenotypes are Decreased homologous recombination repair frequency and Decreased homologous recombination repair frequency

Wikipedia : 76 Cancer phobia, also known as carcinophobia, is an anxiety disorder characterized by the chronic fear of... more...

Related Diseases for Cancerophobia

Diseases related to Cancerophobia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 breast medullary carcinoma 10.0 BRCA1 PGR
2 papillary serous adenocarcinoma 10.0 BRCA1 PGR
3 estrogen-receptor negative breast cancer 9.9 BRCA1 PGR
4 in situ carcinoma 9.9 BRCA1 PGR
5 breast ductal carcinoma 9.7 BRCA1 PGR
6 hereditary site-specific ovarian cancer syndrome 9.7 BRCA1 BRCA2
7 breast reconstruction 9.7 BRCA1 BRCA2
8 tuberculous salpingitis 9.7 BRCA1 BRCA2
9 uterine corpus serous adenocarcinoma 9.6 BRCA1 BRCA2
10 breast-ovarian cancer, familial 1 9.6 BRCA1 BRCA2
11 fallopian tube adenocarcinoma 9.6 BRCA1 BRCA2
12 peritoneum cancer 9.6 BRCA1 BRCA2
13 premature menopause 9.6 BRCA1 BRCA2
14 clear cell adenofibroma 9.6 BRCA1 BRCA2
15 cystadenofibroma 9.6 BRCA1 BRCA2
16 lynch syndrome i 9.6 BRCA1 BRCA2
17 mutagen sensitivity 9.6 BRCA1 BRCA2
18 ovarian cancer 1 9.5 BRCA1 BRCA2
19 hereditary breast ovarian cancer syndrome 9.5 BRCA1 BRCA2
20 cowden disease 9.4 BRCA1 BRCA2
21 li-fraumeni syndrome 9.4 BRCA1 BRCA2
22 lynch syndrome 9.2 BRCA1 BRCA2
23 wilms tumor 1 9.2 BRCA2 PGR
24 synchronous bilateral breast carcinoma 9.1 BRCA1 BRCA2 PGR
25 glycogen-rich clear cell breast carcinoma 9.1 BRCA1 BRCA2 PGR
26 dysgerminoma of ovary 9.1 BRCA1 BRCA2 PGR
27 bilateral breast cancer 9.1 BRCA1 BRCA2 PGR
28 primary peritoneal carcinoma 9.1 BRCA1 BRCA2 PGR
29 pre-malignant neoplasm 9.1 BRCA1 BRCA2 PGR
30 fallopian tube carcinoma 9.1 BRCA1 BRCA2 PGR
31 malignant ovarian surface epithelial-stromal neoplasm 9.1 BRCA1 BRCA2 PGR
32 ovary epithelial cancer 9.1 BRCA1 BRCA2 PGR
33 breast carcinoma in situ 9.1 BRCA1 BRCA2 PGR
34 female breast cancer 9.1 BRCA1 BRCA2 PGR
35 sporadic breast cancer 9.1 BRCA1 BRCA2 PGR
36 ductal carcinoma in situ 9.1 BRCA1 BRCA2 PGR
37 female reproductive organ cancer 9.1 BRCA1 BRCA2 PGR
38 adamantinoma of long bones 9.0 BRCA1 BRCA2 PGR
39 fanconi anemia, complementation group a 8.9 BRCA1 BRCA2
40 endometrial cancer 8.8 BRCA1 BRCA2 PGR
41 ovarian cancer 8.7 BRCA1 BRCA2 PGR
42 nosophobia 8.5 BRCA1 BRCA2 MCIDAS PGR

Graphical network of the top 20 diseases related to Cancerophobia:



Diseases related to Cancerophobia

Symptoms & Phenotypes for Cancerophobia

GenomeRNAi Phenotypes related to Cancerophobia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased homologous recombination repair frequency GR00151-A-1 10.4 BRCA1
2 Decreased homologous recombination repair frequency GR00151-A-2 10.4 BRCA1
3 Decreased homologous recombination repair frequency GR00236-A-1 10.4 BRCA1 BRCA2 PGR
4 Decreased homologous recombination repair frequency GR00236-A-2 10.4 BRCA2 PGR BRCA1
5 Decreased homologous recombination repair frequency GR00236-A-3 10.4 BRCA2 BRCA1
6 Decreased viability after ionizing radiation GR00232-A-2 9.16 BRCA2 BRCA1
7 Decreased viability with cisplatin GR00101-A-4 8.96 BRCA2 BRCA1
8 Synthetic lethal with cisplatin GR00101-A-1 8.62 BRCA2 BRCA1

MGI Mouse Phenotypes related to Cancerophobia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.13 BRCA1 BRCA2 PGR
2 neoplasm MP:0002006 8.8 BRCA1 BRCA2 PGR

Drugs & Therapeutics for Cancerophobia

Drugs for Cancerophobia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 53)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187
2
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
3
Exemestane Approved, Investigational Phase 3 107868-30-4 60198
4
Norepinephrine Approved Phase 3 51-41-2 439260
5
Progesterone Approved, Vet_approved Phase 3 57-83-0 5994
6
Tamoxifen Approved Phase 3 10540-29-1 2733526
7
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
8
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
9 Analgesics Phase 3
10 Chelating Agents Phase 3
11 Selective Estrogen Receptor Modulators Phase 3
12 Serotonin and Noradrenaline Reuptake Inhibitors Phase 3
13 Steroid Synthesis Inhibitors Phase 3
14 Neurotransmitter Agents Phase 3
15 Neurotransmitter Uptake Inhibitors Phase 3
16 Hormone Antagonists Phase 3
17 Hormones Phase 3
18 Dopamine Agents Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Duloxetine Hydrochloride Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Estrogen Antagonists Phase 3
23 Estrogen Receptor Modulators Phase 3
24 Estrogens Phase 3
25 Anticoagulants Phase 3
26 Antidepressive Agents Phase 3
27 Psychotropic Drugs Phase 3
28 Aromatase Inhibitors Phase 3
29 Bone Density Conservation Agents Phase 3
30 Calcium, Dietary Phase 3
31 Antineoplastic Agents, Hormonal Phase 3
32 Citrate Nutraceutical Phase 3
33
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
34
Gemcitabine Approved Phase 2 95058-81-4 60750
35
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
36
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 43805 6857599
37
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
38
Fluorouracil Approved Phase 2 51-21-8 3385
39
Pancrelipase Approved, Investigational Phase 2 53608-75-6
40
Camptothecin Experimental Phase 2 7689-03-4
41 pancreatin Phase 2
42 topoisomerase I inhibitors Phase 2
43 Albumin-Bound Paclitaxel Phase 2
44 Gastrointestinal Agents Phase 2
45 Topoisomerase Inhibitors Phase 2
46 Immunosuppressive Agents Phase 2
47 Anti-Infective Agents Phase 2
48 Antimetabolites Phase 2
49 Antiviral Agents Phase 2
50 Antimetabolites, Antineoplastic Phase 2

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy Active, not recruiting NCT01598298 Phase 3 duloxetine hydrochloride
2 Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Active, not recruiting NCT01272037 Phase 3 Anastrozole;Exemestane;Letrozole;Systemic Chemotherapy;Tamoxifen Citrate
3 Brief CBT for Anxiety and Advanced Cancer Completed NCT00706290 Phase 2
4 Impact of a Group Intervention on Breast Cancer Patient's Adjustment and Emotion Regulation at the End of Treatment Completed NCT01797354 Phase 2
5 Compassion Meditation for Cancer Survivor-Caregiver Dyads Recruiting NCT03459781 Phase 1, Phase 2
6 S1505: Combination Chemotherapy or Gemcitabine Hydrochloride and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Before Surgery in Treating Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02562716 Phase 2 Fluorouracil;Gemcitabine Hydrochloride;Irinotecan Hydrochloride;Oxaliplatin;Paclitaxel Albumin-Stabilized Nanoparticle Formulation
7 Fear of Recurrence Pilot Intervention for Women With Breast Cancer Completed NCT01354041 Phase 1
8 Fear of Cancer Recurrence (FoR) Trajectory During Radiation Treatment Unknown status NCT02599506
9 Feasibility and Efficacy of Internet-delivered CBT for Insomnia in a National Cohort of Danish Breast Cancer Survivors Unknown status NCT02444026 Not Applicable
10 A Therapy Intervention to Address Fear of Recurrence in Men and Women With Cancer Completed NCT02382315 Not Applicable
11 Targeted eHealth Intervention to Reduce Fear of Recurrence Among Breast Cancer Survivors Completed NCT03384992 Not Applicable
12 Investigation of Three Approaches to Address Fear of Recurrence Among Breast Cancer Survivors Completed NCT02611544 Not Applicable
13 Evidence-informed Choice for Women Participating in Mammography Screening Completed NCT01335906 Not Applicable
14 (Cost-)Effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in Cancer Patients Completed NCT02138513 Not Applicable
15 Stress Management for Cancer Survivors Completed NCT01888523 Not Applicable
16 Health Benefits of Expressive Writing: Study One Completed NCT03546673 Not Applicable
17 Evaluation Study of Fear of Cancer Recurrence: Detection, Measure and Risk Factors in Lymphoma Survivorship Recruiting NCT03260855 Not Applicable
18 Cognitive-Existential Group Therapy to Reduce Fear of Cancer Recurrence: A RCT Study Recruiting NCT03270995 Not Applicable
19 Attention and Interpretation Modification (AIM) for Fear of Breast Cancer Recurrence: An Intervention Development Study Recruiting NCT01517945
20 Improving Emotion Regulation at the End of Breast Cancer Treatment Recruiting NCT03336827 Not Applicable
21 Feasibility and Acceptability of a Yoga Intervention in Gynecologic Cancer Recruiting NCT03385577 Not Applicable
22 Acceptance and Commitment Therapy (ACT) for Anxious Cancer Survivors Recruiting NCT02550925 Not Applicable
23 Online MBSR Program for Cancer Survivors With Chronic Neuropathic Pain Recruiting NCT02758197 Not Applicable
24 Cognitively-Based Compassion Training for Breast Cancer Survivors Recruiting NCT03305952 Not Applicable
25 Impact of an Intervention Combining Self-care and Hypnosis on the Well-being of Cancer Patients and Their Partners Recruiting NCT03144154 Not Applicable
26 Cognition in Allogeneic Stem Cell Transplanted Patients and Sports Recruiting NCT02533947 Not Applicable
27 EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer Recruiting NCT02889874 Not Applicable
28 Smart-phone Health Coaching Intervention to Promote Maintenance of Exercise in Breast Cancer Survivors:Protocol Recruiting NCT02620735 Not Applicable
29 Follow-up of Endometrial Cancer Patients Active, not recruiting NCT01853865 Not Applicable
30 Survivorship in Lynch Syndrome Families Active, not recruiting NCT01126840
31 A Communication Skills Package to Prevent Fear of Cancer Recurrence Not yet recruiting NCT03468881
32 Effect of a Resilience Model-Based Care Plan in Newly Diagnosed Colorectal Cancer Patients Not yet recruiting NCT03277235 Not Applicable
33 Group Metacognitive Therapy for Anxiety and Depression in Cancer Survivors Not yet recruiting NCT03424512 Not Applicable
34 The SEAMLESS Study: Smartphone App-based Mindfulness for Cancer Survivors Not yet recruiting NCT03557762 Not Applicable
35 Exercise During Active Surveillance for Prostate Cancer Not yet recruiting NCT03203460 Not Applicable
36 Stepped-Care Telehealth for Distress in Rural Cancer Survivors Not yet recruiting NCT03060096 Not Applicable
37 A Research Study of Patient-led Surveillance Compared to Clinician-led Surveillance in People Treated for Localised Melanoma. Not yet recruiting NCT03581188 Not Applicable
38 Prospective Study Evaluating the Use of PROSPECT to Reduce Insomnia in Patients With Early Stage Breast Cancer Terminated NCT02712437 Not Applicable

Search NIH Clinical Center for Cancerophobia

Genetic Tests for Cancerophobia

Anatomical Context for Cancerophobia

MalaCards organs/tissues related to Cancerophobia:

41
Breast, Prostate, Bone

Publications for Cancerophobia

Articles related to Cancerophobia:

# Title Authors Year
1
When cancerophobia and denial lead to death. ( 19538809 )
2009
2
Cancerophobia and breast fixation. ( 204570 )
1978
3
MANAGEMENT OF THE PATIENT WITH CANCEROPHOBIA AND CANCER. ( 14149368 )
1964
4
Cancerophobia and delusion. ( 13672768 )
1959

Variations for Cancerophobia

Expression for Cancerophobia

Search GEO for disease gene expression data for Cancerophobia.

Pathways for Cancerophobia

GO Terms for Cancerophobia

Cellular components related to Cancerophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lateral element GO:0000800 8.62 BRCA1 BRCA2

Biological processes related to Cancerophobia according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.78 BRCA1 BRCA2 MCIDAS PGR
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.67 BRCA1 MCIDAS PGR
3 cell cycle GO:0007049 9.61 BRCA1 BRCA2 MCIDAS
4 DNA recombination GO:0006310 9.46 BRCA1 BRCA2
5 double-strand break repair via homologous recombination GO:0000724 9.4 BRCA1 BRCA2
6 double-strand break repair GO:0006302 9.37 BRCA1 BRCA2
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.32 BRCA1 BRCA2
8 DNA synthesis involved in DNA repair GO:0000731 9.26 BRCA1 BRCA2
9 strand displacement GO:0000732 9.16 BRCA1 BRCA2
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA1 BRCA2
11 chordate embryonic development GO:0043009 8.62 BRCA1 BRCA2

Molecular functions related to Cancerophobia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 BRCA2 MCIDAS PGR

Sources for Cancerophobia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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