Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 53

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to candidiasis and trichosporonosis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation Pathway and Cytokines and Inflammatory Response. The drugs Voriconazole and Fluconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and neutrophil, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Candida glabrata is a haploid yeast of the genus Candida, previously known as Torulopsis glabrata. This... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 candidiasis 29.0 APCS HTN3 IFNG SKAP2
2 trichosporonosis 10.5 CSF2 IFNG
3 carotid artery thrombosis 10.5 CSF2 IFNG
4 human t-cell leukemia virus type 2 10.4 CSF2 IFNG
5 cyclic neutropenia 10.4 CSF2 IFNG
6 vaginitis 10.4
7 meconium aspiration syndrome 10.4 CSF2 IFNG
8 cytomegalovirus retinitis 10.4 CSF2 IFNG
9 cryptococcal meningitis 10.3 CSF2 IFNG
10 vulvovaginitis 10.3
11 vulvovaginal candidiasis 10.2
12 endophthalmitis 10.2
13 smallpox 10.2 CSF2 IFNG
14 endocarditis 10.2
15 langerhans cell histiocytosis 10.1 CSF2 IFNG
16 aging 10.1
17 chorioamnionitis 10.1
18 osteomyelitis 10.1
19 pneumonia 10.1
20 endotheliitis 10.1
21 parasitic protozoa infectious disease 10.0 DHFR IFNG
22 hematopoietic stem cell transplantation 10.0
23 esophagitis 10.0
24 cholecystitis 10.0
25 peritonitis 10.0
26 pulmonary disease, chronic obstructive 9.8
27 arthritis 9.8
28 chronic granulomatous disease 9.8
29 diabetes mellitus 9.8
30 keratopathy 9.8
31 leukemia 9.8
32 spinal cord injury 9.8
33 aspiration pneumonia 9.8
34 infective endocarditis 9.8
35 colitis 9.8
36 cutaneous candidiasis 9.8
37 mucositis 9.8
38 malignant otitis externa 9.8
39 epidural abscess 9.8
40 heart disease 9.8
41 constrictive pericarditis 9.8
42 nephrotic syndrome 9.8
43 denture stomatitis 9.8
44 neurogenic bladder 9.8
45 olecranon bursitis 9.8
46 urethritis 9.8
47 cystitis 9.8
48 histoplasmosis 9.8
49 pericarditis 9.8
50 orchitis 9.8

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 APCS CSF2 DHFR IFNG RBPJ RIF1
2 immune system MP:0005387 9.56 APCS CSF2 DHFR IFNG RBPJ RIF1
3 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
2
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
5
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
6
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
7 Steroid Synthesis Inhibitors Phase 4
8 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
9 Cytochrome P-450 CYP3A Inhibitors Phase 4
10 Cytochrome P-450 Enzyme Inhibitors Phase 4
11 Hormone Antagonists Phase 4
12 Hormones Phase 4
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
14 Echinocandins Phase 4
15 Anti-Infective Agents Phase 4,Not Applicable
16 Antifungal Agents Phase 4
17
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
18 Sodium hypochlorite Not Applicable
19 chloramine-T Not Applicable
20 Disinfectants Not Applicable
21 Pharmaceutical Solutions Not Applicable
22 Eusol Not Applicable
23 Anti-Infective Agents, Local Not Applicable
24 Castor Nutraceutical Not Applicable
25 Brewer's Yeast Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis Completed NCT00496197 Phase 4 Eraxis (anidulafungin);Diflucan (fluconazole);Vfend (voriconazole)
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319 Not Applicable
4 Clinical and Laboratorial Evaluation of the Desinfection Solutions in Candida Species From Total Prostheses and Palate of Total Edentulous. Completed NCT03203551 Not Applicable
5 Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal Completed NCT02088476
6 Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis Terminated NCT02859493 Not Applicable

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

41
Testes, Colon, Neutrophil, Monocytes, Endothelial, Spleen, Myeloid

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 686)
# Title Authors Year
1
Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study. ( 29929855 )
2018
2
Enhanced Efflux Pump Activity in Old<i>Candida glabrata</i>. ( 29311061 )
2018
3
Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant<i>Candida tropicalis</i>and<i>Candida glabrata</i>isolates with delineation of their resistance mechanisms. ( 29416360 )
2018
4
<i>Cg</i>MED3 affects cell size and budding index to coordinate <i>Candida glabrata</i> cell growth. ( 29776932 )
2018
5
Letter to the editor on &amp;quot;A rare case of Candida glabrata spondylodiscitis: Case report and literature review&amp;quot; by Gagliano et al. ( 29772272 )
2018
6
Diabetes, malignancy and age as predictors of Candida glabrata bloodstream infection: A re-evaluation of the risk factors. ( 29803698 )
2018
7
<i>Candida glabrata</i>: A Unique Cause of Necrotizing Urethritis. ( 29971173 )
2018
8
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans. ( 29249661 )
2018
9
Deletion of<i>ADA2</i>increases antifungal drug susceptibility and virulence in<i>Candida glabrata</i>. ( 29311082 )
2018
10
Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of <i>Candida glabrata</i> in Macrophages. ( 29868018 )
2018
11
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. ( 29798695 )
2018
12
Clonal spread in <i>Candida glabrata</i> bloodstream isolates and fluconazole resistance affected by prolonged exposure: a 12-year single-center study in Belgium. ( 29784839 )
2018
13
Antifungal activity of essential oils against azole-resistant and azole-susceptible vaginal Candida glabrata strains. ( 29746162 )
2018
14
Relative abundance of<i>Candida albicans</i>and<i>Candida glabrata</i>in<i>in vitro</i>co-culture biofilms impacts biofilm structure and formation. ( 29427422 )
2018
15
Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS). ( 29909005 )
2018
16
Management of <i>Candida glabrata</i> infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty. ( 29941758 )
2018
17
Mutant prevention concentration and mutant selection window of micafungin and anidulafungin in clinical<i>Candida glabrata</i>isolates. ( 29311063 )
2018
18
A rare case of Candida glabrata spondylodiscitis: case report and literature review. ( 29339229 )
2018
19
Phytochemical analysis and mode of action against Candida glabrata of Paeonia emodi extracts. ( 29803699 )
2018
20
Identification of Candida glabrata complex species: use of Vitek MS<sup>Ar</sup> RUO &amp;amp; Bruker ClinproTools<sup>Ar</sup>. ( 29745727 )
2018
21
Characterisation of an ABC transporter of a resistant Candida glabrata clinical isolate. ( 29412345 )
2018
22
Synergistic and antagonistic effects of immunomodulatory drugs on the action of antifungals against <i>Candida glabrata</i> and <i>Saccharomyces cerevisiae</i>. ( 29915703 )
2018
23
Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor. ( 29363861 )
2018
24
Adhesins in <i>Candida glabrata</i>. ( 29783771 )
2018
25
Drug susceptibility profile of Candida glabrata clinical isolates from Iran and genetic resistant mechanisms to caspofungin. ( 29685375 )
2018
26
Introducing fluorescence resonance energy transfer-based biosensors for the analysis of cAMP-PKA signalling in the fungal pathogen Candida glabrata. ( 29845711 )
2018
27
Molecular characterization of the silencing complex SIR in Candida glabrata hyperadherent clinical isolates. ( 29857197 )
2018
28
Amphotericin B loaded sulfonated chitosan nanoparticles for targeting macrophages to treat intracellular Candida glabrata infections. ( 29339278 )
2018
29
Fluconazole impacts the extracellular matrix of fluconazole-susceptible and -resistant <i>Candida albicans</i> and <i>Candida glabrata</i> biofilms. ( 29887974 )
2018
30
Comparative Study of the Effects of Fluconazole and Voriconazole on Candida glabrata, Candida parapsilosis and Candida rugosa Biofilms. ( 29380188 )
2018
31
Biguanides enhance antifungal activity against Candida glabrata. ( 29962263 )
2018
32
Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata. ( 29248112 )
2018
33
Activity and expression of Candida glabrata vacuolar proteases in autophagy-like conditions. ( 29385574 )
2018
34
Enantioselective bioreduction of benzo-fused cyclic ketones with engineered Candida glabrata ketoreductase 1 - a promising synthetic route to ladostigil (TV3326). ( 28848953 )
2017
35
Quantification of CDR1 Gene Expression in Fluconazole Resistant Candida Glabrata Strains Using Real-time PCR. ( 28894714 )
2017
36
Dectin-1 plays an important role in host defense against systemic Candida glabrata infection. ( 28658592 )
2017
37
The phosphorelay signal transduction system in Candida glabrata: an in silico analysis. ( 29248994 )
2017
38
Candida glabrata Biofilms: How Far Have We Come? ( 29371530 )
2017
39
De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance. ( 28630180 )
2017
40
Emergence of Candida glabrata in vulvovaginal candidiasis should be attributed to selective pressure or virulence ability? ( 28730269 )
2017
41
CgMED3 Changes Membrane Sterol Composition To Help Candida glabrata Tolerate Low-pH Stress. ( 28667115 )
2017
42
Relationship between the Antifungal Susceptibility Profile and the Production of Virulence-Related Hydrolytic Enzymes in Brazilian Clinical Strains of Candida glabrata. ( 28814823 )
2017
43
Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates. ( 28663342 )
2017
44
The CgHaa1-Regulon Mediates Response and Tolerance to Acetic Acid Stress in the Human Pathogen Candida glabrata. ( 27815348 )
2017
45
Candida glabrata prosthetic joint infection, successfully treated with anidulafungin: A case report and review of the literature. ( 29272049 )
2017
46
Functional analysis of selected deletion mutants in Candida glabrata under hypoxia. ( 28664376 )
2017
47
Med15B Regulates Acid Stress Response and Tolerance in Candida glabrata by Altering Membrane Lipid Composition. ( 28710262 )
2017
48
Interactions between Candida albicans and Candida glabrata in biofilms: Influence of the strain type, culture medium and glucose supplementation. ( 29274093 )
2017
49
Potential Use of MALDI-ToF Mass Spectrometry for Rapid Detection of Antifungal Resistance in the Human Pathogen Candida glabrata. ( 28831086 )
2017
50
Genome mining, in silico validation and phase selection of a novel aldo-keto reductase from Candida glabrata for biotransformation. ( 28644714 )
2017

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 IFNG RBPJ
2 10.1 CSF2 IFNG

GO Terms for Candida Glabrata

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.54 HTN1 HTN3 RBPJ
2 humoral immune response GO:0006959 9.48 IFNG RBPJ
3 antimicrobial humoral response GO:0019730 9.46 HTN1 HTN3
4 cholesterol biosynthetic process GO:0006695 9.43 LSS SQLE
5 killing of cells of other organism GO:0031640 9.4 HTN1 HTN3
6 regulation of cholesterol biosynthetic process GO:0045540 9.32 LSS SQLE
7 biomineral tissue development GO:0031214 9.26 HTN1 HTN3
8 defense response to fungus GO:0050832 9.16 HTN1 HTN3
9 myeloid dendritic cell differentiation GO:0043011 8.96 CSF2 RBPJ
10 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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