MCID: CND006
MIFTS: 32

Candida Glabrata

Categories: Rare diseases

Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 52

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to chorioretinitis and candidiasis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The drugs Caspofungin and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and liver, and related phenotypes are hematopoietic system and embryo

Wikipedia : 74 Candida glabrata is a species of haploid yeast of the genus Candida, previously known as Torulopsis... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 chorioretinitis 30.6 IFNG DHFR
2 candidiasis 30.3 SKAP2 IFNG HTN3 CSF2 APCS
3 oral candidiasis 30.0 SKAP2 HTN3
4 fungal infectious disease 29.8 SKAP2 IFNG CSF2
5 pneumonia 29.7 IFNG DHFR CSF2
6 opportunistic mycosis 29.4 SKAP2 IFNG CSF2
7 vaginitis 10.6
8 endocarditis 10.6
9 vulvovaginal candidiasis 10.6
10 endophthalmitis 10.5
11 denture stomatitis 10.4
12 stomatitis 10.4
13 48,xyyy 10.4
14 osteomyelitis 10.4
15 acute cystitis 10.4
16 chorioamnionitis 10.4
17 vulvovaginitis 10.4
18 peritonitis 10.4
19 amyotrophic lateral sclerosis 3 10.4
20 pyelonephritis 10.4
21 keratitis, hereditary 10.3
22 infective endocarditis 10.3
23 neutropenia 10.3
24 diarrhea 10.3
25 septic arthritis 10.3
26 47,xyy 10.3
27 cytokine deficiency 10.3
28 overgrowth syndrome 10.3
29 renal artery obstruction 10.2 HTN3 HTN1
30 human t-cell leukemia virus type 2 10.2 IFNG CSF2
31 carotid artery thrombosis 10.2 IFNG CSF2
32 pulmonary disease, chronic obstructive 10.2
33 aspergillosis 10.2
34 aspiration pneumonia 10.2
35 thrombotic thrombocytopenic purpura 10.2
36 esophagitis 10.2
37 toxic shock syndrome 10.2
38 cystitis 10.2
39 purpura 10.2
40 meningitis 10.2
41 prosthetic joint infection 10.2
42 hypoxia 10.2
43 mucormycosis 10.2 IFNG CSF2
44 fungal meningitis 10.2 IFNG CSF2
45 primary systemic mycosis 10.2 IFNG CSF2
46 meconium aspiration syndrome 10.2 IFNG CSF2
47 cytomegalovirus retinitis 10.2 IFNG CSF2
48 palmoplantar keratoderma and congenital alopecia 2 10.1 SQLE LSS
49 cryptosporidiosis 10.1 IFNG DHFR
50 cryptococcal meningitis 10.1 IFNG CSF2

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 APCS CSF2 DHFR IFNG LSS RBPJ
2 embryo MP:0005380 9.73 CSF2 DHFR IFNG RBPJ RIF1 SQLE
3 immune system MP:0005387 9.61 APCS CSF2 DHFR IFNG LSS RBPJ
4 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
2
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
5 Echinocandins Phase 4
6 Antifungal Agents Phase 4
7 Anti-Infective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins in Patients With Presumptive Candidemia Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Systemic Fungal Infections in Intensive Care Unit Patients Unknown status NCT03292224
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319
4 Method Comparison Protocol: MALDI Biotyper-Clinical Applications (MBT-CA) Phase 2 Unknown status NCT02098226
5 Retrospective Chart Review of Candida Fungemia Active, not recruiting NCT03827330
6 Open, Prospective, Multicenter Trial to Evaluate the Clinical Significance of Combined Serological (Galactomannan ELISA, 1->3-β-D Glucan Assay) and Molecular (Nested Aspergillus PCR Assay, Multifungal DNA Microarray) Diagnostic Assays to Detect and Characterize Fungal Pathogens in Bronchoalveolar Lavage (BAL) and Blood Samples of Hematological High Risk Patients and to Detect Point Mutations Conferring Azole Resistance Enrolling by invitation NCT01695512
7 Natural History of Atherosclerosis Within the Concept of the Glagovian Artery Remodeling in REAL-world Chest Pain Population Underwent Computed Tomography Angiography and 3D Quantitative Coronary Angiography: Clinical potentIal and safeTY Enrolling by invitation NCT02440646

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

40
Testes, Colon, Liver, Neutrophil, Endothelial, Kidney, Bone

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 3316)
# Title Authors PMID Year
1
Multi-route antifungal administration in the management of urinary Candida glabrata bezoar. 61
32489899 2020
2
Fungal biotin homeostasis is essential for immune evasion after macrophage phagocytosis and virulence. 61
32083801 2020
3
Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk. 61
32570731 2020
4
Penile Implant Infection: Experience With Expanded Salvage Criteria and a Shortened Course of Postoperative Antibiotics. 61
32532702 2020
5
Manogepix (APX001A) Displays Potent In Vitro Activity against Human Pathogenic Yeast, but with an Unexpected Correlation to Fluconazole MICs. 61
32366708 2020
6
A new isoflavonol and other constituents from Cameroonian propolis and evaluation of their anti-inflammatory, antifungal and antioxidant potential. 61
32489308 2020
7
Successful management of the first reported case in Austria of COVID-19 with ARDS. 61
32535876 2020
8
Does concomitant bacteraemia hide the fungi in blood cultures? An in vitro study. 61
32490795 2020
9
[Antimicrobial activity of Rosmarinus officinalis and Zingiber officinale extracts on the species of the genus Candida and on Streptococcus pneumonia.] 61
32565159 2020
10
Repurposing the thrombopoietin receptor agonist eltrombopag as an anticryptococcal agent. 61
31297540 2020
11
[Pathogenicity and drug-resistance analysis of Candida glabrata in patients with oral candidiasis]. 61
32536122 2020
12
Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes. 61
31509195 2020
13
Rapid identification of the Candida glabrata species complex by high-resolution melting curve analysis. 61
32048348 2020
14
De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays. 61
32068314 2020
15
Genetic Basis of Azole and Echinocandin Resistance in Clinical Candida glabrata in Japan. 61
32571826 2020
16
Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata. 61
32555245 2020
17
A homologous overexpression system to study roles of drug transporters in Candida glabrata. 61
32490522 2020
18
Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance Through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability. 61
32571817 2020
19
A gain-of-function mutation in PDR1 of Candida glabrata decreases EPA1 expression and attenuates adherence to epithelial cells through enhancing recruitment of the Mediator subunit Gal11A. 61
32563123 2020
20
Clinical Usefulness of Susceptibility Breakpoints for Yeasts in the Treatment of Candidemia: A Noninterventional Study. 61
32498436 2020
21
Catechol-bearing imidazolium and benzimidazolium chlorides as promising antimicrobial agents. 61
32301169 2020
22
Genome protection: histone H4 and beyond. 61
32556547 2020
23
Deep-AmPEP30: Improve Short Antimicrobial Peptides Prediction with Deep Learning. 61
32464552 2020
24
Functional characteristics of Svl3 and Pam1 that are required for proper cell wall formation in yeast cells. 61
32491201 2020
25
RNase 1, 2, 5 & 8 role in innate immunity: Strain specific antimicrobial activity. 61
32504708 2020
26
Candida Species-Dependent Release of IL-12 by Dendritic Cells Induces Different Levels of NK Cell Stimulation. 61
31993642 2020
27
Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. 61
32398316 2020
28
Epidemiology of yeast species causing bloodstream infection in Tehran, Iran (2015-2017); superiority of 21-plex PCR over the Vitek 2 system for yeast identification. 61
32368996 2020
29
Assessment of micafungin loading dosage regimens against Candida spp. in ICU patients by Monte Carlo simulations. 61
32047965 2020
30
In Vitro Antimicrobial Activity of Effervescent Denture Tablets on the Components of Removable Partial Dentures. 61
32320185 2020
31
Antifungal and anti-biofilm activity of designed derivatives from kyotorphin. 61
32389294 2020
32
Green Approach to Overcome the Resistance Pattern of Candida spp. Using Biosynthesized Silver Nanoparticles Fabricated by Penicillium chrysogenum F9. 61
32451695 2020
33
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond. 61
32441527 2020
34
Iron Metabolism, Pseudohypha Production, and Biofilm Formation through a Multicopper Oxidase in the Human-Pathogenic Fungus Candida parapsilosis. 61
32404511 2020
35
Prevalence of vulvovaginal candidiasis among pregnant women in the Ho municipality, Ghana: species identification and antifungal susceptibility of Candida isolates. 61
32375724 2020
36
Acute Candida glabrata Parotitis with Fungemia after Major Pelvic Oncologic Surgical Procedure. 61
32466720 2020
37
Low level of antifungal resistance of Candida glabrata blood isolates in Turkey: fluconazole minimum inhibitory concentration and FKS mutations can predict therapeutic failure. 61
32413170 2020
38
Impact of calmodulin inhibition by fluphenazine on susceptibility, biofilm formation and pathogenicity of caspofungin-resistant Candida glabrata. 61
32011702 2020
39
Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion. 61
32428860 2020
40
Abundance interaction in Candida albicans and Candida glabrata mixed biofilms under diverse conditions. 61
32453815 2020
41
Transcriptomic analysis reveals global and temporal transcription changes during Candida glabrata adaptation to an oxidative environment. 61
32389305 2020
42
CgCmk1 Activates CgRds2 To Resist Low-pH Stress in Candida glabrata. 61
32245757 2020
43
Analysis of the microbial species, antimicrobial sensitivity and drug resistance in 2652 patients of nursing hospital. 61
32490228 2020
44
Synthesis, antimicrobial activity and molecular docking study of novel α-(diphenylphosphoryl)- and α-(diphenylphosphorothioyl)cycloalkanone oximes. 61
32421207 2020
45
Crystal structure and transient dimerization for the FKBP12 protein from the pathogenic fungus Candida auris. 61
32184021 2020
46
Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents. 61
32391537 2020
47
Different efficacies of common disinfection methods against candida auris and other candida species. 61
32005617 2020
48
Microbiology and clinical characteristics of industrial oil burns. 61
31761453 2020
49
The Epithelial adhesin 1 tandem repeat region mediates protein display through multiple mechanisms. 61
32301985 2020
50
Molecular simulations of fluconazole-mediated inhibition of sterol biosynthesis. 61
31062656 2020

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 RBPJ IFNG
2
Show member pathways
10.51 IFNG CSF2
3 10.09 IFNG CSF2

GO Terms for Candida Glabrata

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.65 RBPJ HTN3 HTN1
2 regulation of cell proliferation GO:0042127 9.58 SQLE RBPJ CSF2
3 cholesterol biosynthetic process GO:0006695 9.46 SQLE LSS
4 killing of cells of other organism GO:0031640 9.43 HTN3 HTN1
5 regulation of cholesterol biosynthetic process GO:0045540 9.37 SQLE LSS
6 biomineral tissue development GO:0031214 9.32 HTN3 HTN1
7 defense response to fungus GO:0050832 9.26 HTN3 HTN1
8 macrophage differentiation GO:0030225 9.16 IFNG CSF2
9 myeloid dendritic cell differentiation GO:0043011 8.96 RBPJ CSF2
10 positive regulation of interleukin-23 production GO:0032747 8.62 IFNG CSF2

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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