MCID: CND006
MIFTS: 37

Candida Glabrata

Categories: Rare diseases

Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 53

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to candidiasis and oral candidiasis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation Pathway and Cytokines and Inflammatory Response. The drugs Caspofungin and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and neutrophil, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Candida glabrata is a haploid yeast of the genus Candida, previously known as Torulopsis glabrata. This... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 candidiasis 30.6 APCS HTN3 IFNG SKAP2
2 oral candidiasis 30.0 HTN3 SKAP2
3 endocarditis 10.4
4 endophthalmitis 10.4
5 vaginitis 10.4
6 osteomyelitis 10.3
7 vulvovaginal candidiasis 10.3
8 chorioamnionitis 10.3
9 peritonitis 10.3
10 arthritis 10.2
11 esophagitis 10.2
12 vulvovaginitis 10.2
13 pneumonia 10.2
14 meningitis 10.2
15 large granular lymphocyte leukemia 10.2 CSF2 IFNG
16 trichosporonosis 10.2 CSF2 IFNG
17 mucormycosis 10.2 CSF2 IFNG
18 carotid artery thrombosis 10.2 CSF2 IFNG
19 human t-cell leukemia virus type 2 10.2 CSF2 IFNG
20 meconium aspiration syndrome 10.2 CSF2 IFNG
21 hypersplenism 10.1 CSF2 IFNG
22 cytomegalovirus retinitis 10.1 CSF2 IFNG
23 cryptococcal meningitis 10.1 CSF2 IFNG
24 colitis 10.1
25 cholecystitis 10.1
26 hypoxia 10.1
27 smallpox 10.1 CSF2 IFNG
28 langerhans cell histiocytosis 10.1 CSF2 IFNG
29 parasitic protozoa infectious disease 10.0 DHFR IFNG
30 opportunistic mycosis 10.0 IFNG SKAP2
31 pulmonary sarcoidosis 10.0 CSF2 IFNG
32 tetralogy of fallot 9.9
33 pulmonary disease, chronic obstructive 9.9
34 chronic granulomatous disease 9.9
35 diabetes mellitus 9.9
36 hematopoietic stem cell transplantation 9.9
37 keratopathy 9.9
38 leukemia 9.9
39 neutropenia 9.9
40 spinal cord injury 9.9
41 aspiration pneumonia 9.9
42 infective endocarditis 9.9
43 lymphoma 9.9
44 thrombosis 9.9
45 cutaneous candidiasis 9.9
46 mucositis 9.9
47 malignant otitis externa 9.9
48 esophagus lymphoma 9.9
49 epidural abscess 9.9
50 heart disease 9.9

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 APCS CSF2 DHFR IFNG RBPJ RIF1
2 immune system MP:0005387 9.56 APCS CSF2 DHFR IFNG RBPJ RIF1
3 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 179463-17-3, 162808-62-0 468682 2826718
2
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
3
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
6
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
7 Anti-Infective Agents Phase 4,Not Applicable
8 Echinocandins Phase 4
9 Antifungal Agents Phase 4
10 Cytochrome P-450 CYP3A Inhibitors Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Steroid Synthesis Inhibitors Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Hormones Phase 4
15 Hormone Antagonists Phase 4
16 Cytochrome P-450 CYP2C19 Inhibitors Phase 4
17 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
18
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
19 chloramine-T Not Applicable
20 Pharmaceutical Solutions Not Applicable
21 Eusol Not Applicable
22 Castor Not Applicable
23 Anti-Infective Agents, Local Not Applicable
24 Sodium hypochlorite Not Applicable
25 Disinfectants Not Applicable
26 Brewer's Yeast Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis Completed NCT00496197 Phase 4 Eraxis (anidulafungin);Diflucan (fluconazole);Vfend (voriconazole)
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319 Not Applicable
4 Clinical and Laboratorial Evaluation of the Desinfection Solutions in Candida Species From Total Prostheses and Palate of Total Edentulous. Completed NCT03203551 Not Applicable
5 Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal Completed NCT02088476
6 Study of Innate Host Immune Response to C. Glabrata Clinical Isolates Resistant to Echinocandins: Impact on the Management of Candidemia in High-risk Patients Active, not recruiting NCT03652194
7 Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis Terminated NCT02859493 Not Applicable

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

41
Testes, Colon, Neutrophil, Heart, Monocytes, Spinal Cord, Myeloid

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 994)
# Title Authors Year
1
Impact of high MIC of fluconazole on outcomes of Candida glabrata bloodstream infection: a retrospective multicenter cohort study. ( 29929855 )
2018
2
Enhanced Efflux Pump Activity in Old<i>Candida glabrata</i>. ( 29311061 )
2018
3
Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant<i>Candida tropicalis</i>and<i>Candida glabrata</i>isolates with delineation of their resistance mechanisms. ( 29416360 )
2018
4
<i>Cg</i>MED3 affects cell size and budding index to coordinate <i>Candida glabrata</i> cell growth. ( 29776932 )
2018
5
Letter to the editor on &amp;quot;A rare case of Candida glabrata spondylodiscitis: Case report and literature review&amp;quot; by Gagliano et al. ( 29772272 )
2018
6
Diabetes, malignancy and age as predictors of Candida glabrata bloodstream infection: A re-evaluation of the risk factors. ( 29803698 )
2018
7
<i>Candida glabrata</i>: A Unique Cause of Necrotizing Urethritis. ( 29971173 )
2018
8
Patterns of Genomic Variation in the Opportunistic Pathogen Candida glabrata Suggest the Existence of Mating and a Secondary Association with Humans. ( 29249661 )
2018
9
Deletion of<i>ADA2</i>increases antifungal drug susceptibility and virulence in<i>Candida glabrata</i>. ( 29311082 )
2018
10
Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of <i>Candida glabrata</i> in Macrophages. ( 29868018 )
2018
11
Susceptibility of Candida glabrata biofilms to echinocandins: alterations in the matrix composition. ( 29798695 )
2018
12
Clonal spread in <i>Candida glabrata</i> bloodstream isolates and fluconazole resistance affected by prolonged exposure: a 12-year single-center study in Belgium. ( 29784839 )
2018
13
Antifungal activity of essential oils against azole-resistant and azole-susceptible vaginal Candida glabrata strains. ( 29746162 )
2018
14
Relative abundance of<i>Candida albicans</i>and<i>Candida glabrata</i>in<i>in vitro</i>co-culture biofilms impacts biofilm structure and formation. ( 29427422 )
2018
15
Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS). ( 29909005 )
2018
16
Management of <i>Candida glabrata</i> infectious crystalline keratopathy with endophthalmitis following penetrating keratoplasty. ( 29941758 )
2018
17
Mutant prevention concentration and mutant selection window of micafungin and anidulafungin in clinical<i>Candida glabrata</i>isolates. ( 29311063 )
2018
18
A rare case of Candida glabrata spondylodiscitis: case report and literature review. ( 29339229 )
2018
19
Phytochemical analysis and mode of action against Candida glabrata of Paeonia emodi extracts. ( 29803699 )
2018
20
Identification of Candida glabrata complex species: use of Vitek MS<sup>Ar</sup> RUO &amp;amp; Bruker ClinproTools<sup>Ar</sup>. ( 29745727 )
2018
21
Characterisation of an ABC transporter of a resistant Candida glabrata clinical isolate. ( 29412345 )
2018
22
Synergistic and antagonistic effects of immunomodulatory drugs on the action of antifungals against <i>Candida glabrata</i> and <i>Saccharomyces cerevisiae</i>. ( 29915703 )
2018
23
Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor. ( 29363861 )
2018
24
Adhesins in <i>Candida glabrata</i>. ( 29783771 )
2018
25
Drug susceptibility profile of Candida glabrata clinical isolates from Iran and genetic resistant mechanisms to caspofungin. ( 29685375 )
2018
26
Introducing fluorescence resonance energy transfer-based biosensors for the analysis of cAMP-PKA signalling in the fungal pathogen Candida glabrata. ( 29845711 )
2018
27
Molecular characterization of the silencing complex SIR in Candida glabrata hyperadherent clinical isolates. ( 29857197 )
2018
28
Amphotericin B loaded sulfonated chitosan nanoparticles for targeting macrophages to treat intracellular Candida glabrata infections. ( 29339278 )
2018
29
Fluconazole impacts the extracellular matrix of fluconazole-susceptible and -resistant <i>Candida albicans</i> and <i>Candida glabrata</i> biofilms. ( 29887974 )
2018
30
Comparative Study of the Effects of Fluconazole and Voriconazole on Candida glabrata, Candida parapsilosis and Candida rugosa Biofilms. ( 29380188 )
2018
31
Biguanides enhance antifungal activity against Candida glabrata. ( 29962263 )
2018
32
Cooperation between ER stress and calcineurin signaling contributes to the maintenance of cell wall integrity in Candida glabrata. ( 29248112 )
2018
33
Activity and expression of Candida glabrata vacuolar proteases in autophagy-like conditions. ( 29385574 )
2018
34
Endoscopic Endonasal Transsphenoidal Drainage of a Spontaneous Candida glabrata Pituitary Abscess. ( 29079259 )
2018
35
Comparative genomic and transcriptomic analyses unveil novel features of azole resistance and adaptation to the human host in Candida glabrata. ( 29087506 )
2018
36
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. ( 29164434 )
2018
37
Carboxymethylated ɩ-carrageenan conjugated amphotericin B loaded gelatin nanoparticles for treating intracellular Candida glabrata infections. ( 29169943 )
2018
38
Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata. ( 29177447 )
2018
39
Multiple brain abscesses caused by infection with Candida glabrata: A case report. ( 29456643 )
2018
40
Fibrin Web in a Patient with Candida glabrata Endophthalmitis. ( 29458827 )
2018
41
Comparative virulence of Candida auris with Candida haemulonii, Candida glabrata and Candida albicans in a murine model. ( 29460345 )
2018
42
Remodeling of the Candida glabrata cell wall in the gastrointestinal tract affects the gut microbiota and the immune response. ( 29463799 )
2018
43
CgPDR1 gain-of-function mutations lead to azole-resistance and increased adhesion in clinical Candida glabrata strains. ( 29464833 )
2018
44
Aspartyl proteases in Candida glabrata are required for suppression of the host innate immune response. ( 29491142 )
2018
45
Jjj1 Is a Negative Regulator of Pdr1-Mediated Fluconazole Resistance in Candida glabrata. ( 29507891 )
2018
46
Sterol uptake and sterol biosynthesis act coordinately to mediate antifungal resistance in Candida glabrata under azole and hypoxic stress. ( 29532896 )
2018
47
A Host-Pathogen Interaction Screen Identifies ada2 as a Mediator of Candida glabrata Defenses Against Reactive Oxygen Species. ( 29535147 )
2018
48
Overcoming the Resistance Hurdle: Pharmacokinetic-Pharmacodynamic Target Attainment Analyses for Rezafungin (CD101) against Candida albicans and Candida glabrata. ( 29555634 )
2018
49
Evaluation of the DiversiLab® automated repetitive sequence-based PCR system for the characterization of Candida albicans and Candida glabrata isolates. ( 29580647 )
2018
50
Profiling of PDR1 and MSH2 in Candida glabrata Bloodstream Isolates from a Multicenter Study in China. ( 29581110 )
2018

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 IFNG RBPJ
2 10.09 CSF2 IFNG

GO Terms for Candida Glabrata

Cellular components related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 APCS CSF2 HTN1 HTN3 IFNG TPSAB1

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.61 HTN1 HTN3 RBPJ
2 humoral immune response GO:0006959 9.48 IFNG RBPJ
3 antimicrobial humoral response GO:0019730 9.46 HTN1 HTN3
4 cholesterol biosynthetic process GO:0006695 9.4 LSS SQLE
5 killing of cells of other organism GO:0031640 9.37 HTN1 HTN3
6 biomineral tissue development GO:0031214 9.32 HTN1 HTN3
7 regulation of cholesterol biosynthetic process GO:0045540 9.26 LSS SQLE
8 defense response to fungus GO:0050832 9.16 HTN1 HTN3
9 myeloid dendritic cell differentiation GO:0043011 8.96 CSF2 RBPJ
10 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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