MCID: CND006
MIFTS: 32

Candida Glabrata

Categories: Rare diseases

Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 52

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to chorioretinitis and vulvovaginal candidiasis. An important gene associated with Candida Glabrata is CSF2 (Colony Stimulating Factor 2), and among its related pathways/superpathways are Th2 Differentiation Pathway and Cytokines and Inflammatory Response. The drugs Caspofungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and liver, and related phenotypes are hematopoietic system and embryo

Wikipedia : 74 Candida glabrata is a species of haploid yeast of the genus Candida, previously known as Torulopsis... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 chorioretinitis 30.6 IFNG DHFR
2 vulvovaginal candidiasis 30.4 SKAP2 IFNG
3 candidiasis 30.3 SKAP2 IFNG HTN3 CSF2 APCS
4 oral candidiasis 30.1 SKAP2 HTN3
5 opportunistic mycosis 29.4 SKAP2 IFNG CSF2
6 vaginitis 10.6
7 endocarditis 10.6
8 endophthalmitis 10.5
9 denture stomatitis 10.4
10 stomatitis 10.4
11 48,xyyy 10.4
12 osteomyelitis 10.4
13 acute cystitis 10.4
14 chorioamnionitis 10.4
15 vulvovaginitis 10.4
16 peritonitis 10.4
17 amyotrophic lateral sclerosis 3 10.4
18 pyelonephritis 10.3
19 neutropenia 10.3
20 keratitis, hereditary 10.3
21 infective endocarditis 10.3
22 diarrhea 10.3
23 septic arthritis 10.3
24 47,xyy 10.3
25 cytokine deficiency 10.3
26 overgrowth syndrome 10.3
27 human t-cell leukemia virus type 2 10.2 IFNG CSF2
28 carotid artery thrombosis 10.2 IFNG CSF2
29 fungal meningitis 10.2 IFNG CSF2
30 mucormycosis 10.2 IFNG CSF2
31 pulmonary disease, chronic obstructive 10.2
32 aspergillosis 10.2
33 aspiration pneumonia 10.2
34 thrombotic thrombocytopenic purpura 10.2
35 esophagitis 10.2
36 toxic shock syndrome 10.2
37 cystitis 10.2
38 purpura 10.2
39 meningitis 10.2
40 prosthetic joint infection 10.2
41 hypoxia 10.2
42 primary systemic mycosis 10.2 IFNG CSF2
43 meconium aspiration syndrome 10.2 IFNG CSF2
44 cytomegalovirus retinitis 10.2 IFNG CSF2
45 cryptococcal meningitis 10.2 IFNG CSF2
46 hypersplenism 10.2 IFNG CSF2
47 cryptococcosis 10.1 IFNG CSF2
48 splenic disease 10.1 IFNG CSF2
49 hypercholesterolemia, familial, 1 10.1
50 thyroid dyshormonogenesis 3 10.1

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.76 APCS CSF2 DHFR IFNG LSS RBPJ
2 embryo MP:0005380 9.73 CSF2 DHFR IFNG RBPJ RIF1 SQLE
3 immune system MP:0005387 9.61 APCS CSF2 DHFR IFNG LSS RBPJ
4 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 468682 2826718
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Micafungin Approved, Investigational Phase 4 235114-32-6 3081921 477468
4 Antifungal Agents Phase 4
5 Echinocandins Phase 4
6 Anti-Infective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins in Patients With Presumptive Candidemia Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Systemic Fungal Infections in Intensive Care Unit Patients Unknown status NCT03292224
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319
4 Method Comparison Protocol: MALDI Biotyper-Clinical Applications (MBT-CA) Phase 2 Unknown status NCT02098226
5 Retrospective Chart Review of Candida Fungemia Active, not recruiting NCT03827330
6 Open, Prospective, Multicenter Trial to Evaluate the Clinical Significance of Combined Serological (Galactomannan ELISA, 1->3-β-D Glucan Assay) and Molecular (Nested Aspergillus PCR Assay, Multifungal DNA Microarray) Diagnostic Assays to Detect and Characterize Fungal Pathogens in Bronchoalveolar Lavage (BAL) and Blood Samples of Hematological High Risk Patients and to Detect Point Mutations Conferring Azole Resistance Enrolling by invitation NCT01695512
7 Natural History of Atherosclerosis Within the Concept of the Glagovian Artery Remodeling in REAL-world Chest Pain Population Underwent Computed Tomography Angiography and 3D Quantitative Coronary Angiography: Clinical potentIal and safeTY Enrolling by invitation NCT02440646

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

40
Testes, Colon, Liver, Kidney, Heart, Endothelial, Neutrophil

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 3233)
# Title Authors PMID Year
1
Excision of endosymbiotic bacteria from yeast under aging and starvation stresses. 61
31839588 2020
2
2-Phenylethanol and 2-phenylethylacetate production by nonconventional yeasts using tequila vinasses as a substrate. 61
32025510 2020
3
Ethno-medicinal study of Artemisia ordosica Krasch. (traditional Chinese/Mongolian medicine) extracts for the treatment of allergic rhinitis and nasosinusitis. 61
31585162 2020
4
Impact of calmodulin inhibition by fluphenazine on susceptibility, biofilm formation and pathogenicity of caspofungin-resistant Candida glabrata. 61
32011702 2020
5
Candida glabrata peroxiredoxins, Tsa1 and Tsa2, and sulfiredoxin, Srx1, protect against oxidative damage and are necessary for virulence. 61
31654781 2020
6
Don't mess with the machine - evaluation of fluconazole susceptibility testing for Candida glabrata using the new VITEK2 AST-YS08 card following species modification. 61
31780195 2020
7
Resistance to echinocandin antifungal agents in the United Kingdom in clinical isolates of Candida glabrata: Fifteen years of interpretation and assessment. 61
31111912 2020
8
Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms. 61
31676401 2020
9
Electroporation and Mass Spectrometry: A New Paradigm for In Situ Analysis of Intact Proteins Direct from Living Yeast Colonies. 61
31922714 2020
10
Activity of a Long-Acting Echinocandin, Rezafungin, and Comparator Antifungal Agents Tested against Contemporary Invasive Fungal Isolates: SENTRY Program 2016-2018. 61
32015043 2020
11
Clinical Validation of the Aptima Bacterial Vaginosis and Aptima Candida/Trichomonas Vaginitis Assays: Results from a Prospective Multicenter Clinical Study. 61
31748322 2020
12
Exploring the role of oral microorganisms in the pathogenesis of mucositis by assessing their impact on metabolic activity and reproductive capacity of epithelial cells in vitro. 61
31965308 2020
13
New Triazole NT-a9 Has Potent Antifungal Efficacy against Cryptococcus neoformans In Vitro and In Vivo. 61
31791946 2020
14
Clinical Characteristics and Antifungal Susceptibility of Candida nivariensis from Vulvovaginal Candidiasis. 61
31694024 2020
15
Inhibiting Fungal Echinocandin Resistance by Small-Molecule Disruption of Geranylgeranyltransferase Type I Activity. 61
31791942 2020
16
Expression of ERG11 and efflux pump genes CDR1, CDR2 and SNQ2 in voriconazole susceptible and resistant Candida glabrata strains. 61
30843047 2020
17
Novel Triazole Derivatives Containing Different Ester Skeleton: Design, Synthesis, Biological Evaluation and Molecular Docking. 61
31708557 2020
18
1H, 13C, 15 N chemical shift assignments of the FKBP12 protein from the pathogenic fungi Candida auris and Candida glabrata. 61
31950462 2020
19
Voriconazole efficacy against Candida glabrata and Candida krusei: preclinical data using a validated in vitro pharmacokinetic/pharmacodynamic model. 61
31665417 2020
20
A Novel cis Element Achieves the Same Solution as an Ancestral cis Element During Thiamine Starvation in Candida glabrata. 61
31732505 2020
21
Global Secretome Characterization of the Pathogenic Yeast Candida glabrata. 61
31621333 2020
22
Transcriptional responses of Candida glabrata biofilm cells to fluconazole are modulated by the carbon source. 61
31993211 2020
23
New antifungal ent-labdane diterpenes against Candida glabrata produced by microbial transformation of ent-polyalthic acid. 61
31918399 2020
24
Enhancement of pyruvic acid production in Candida glabrata by engineering hypoxia-inducible factor 1. 61
31627065 2020
25
Different efficacies of common disinfection methods against candida auris and other candida species. 61
32005617 2020
26
Chilean crab (Aegla cholchol) as a new source of chitin and chitosan with antifungal properties against Candida spp. 61
32006582 2020
27
Candida biofilm production is associated with higher mortality in patients with candidaemia. 61
31943428 2020
28
Population Pharmacokinetics of Intravenous Isavuconazole in Solid-Organ Transplant Recipients. 61
31767725 2020
29
Candida species-dependent release of IL-12 by dendritic cells induces different levels of NK cell stimulation. 61
31993642 2020
30
The Daisho Peptides Mediate Drosophila Defense Against a Subset of Filamentous Fungi. 61
32038657 2020
31
Fungicidal and anti-biofilm activities of trimethylchitosan-stabilized silver nanoparticles against Candida species in zebrafish embryos. 61
31734360 2020
32
Application of High-Resolution Melting PCR to Detect the Genomic Fungal ITS 2 Region. 61
31198973 2020
33
Green Synthesis of Encapsulated Copper Nanoparticles Using a Hydroalcoholic Extract of Moringa oleifera Leaves and Assessment of Their Antioxidant and Antimicrobial Activities. 61
32012912 2020
34
[Analysis of the pathogenic characteristics of fungal bloodstream infection in severe burn patients]. 61
32023716 2020
35
In vitro Antifungal Effects of Berberine Against Candida spp. In Planktonic and Biofilm Conditions. 61
32021094 2020
36
Analysis of global antifungal surveillance results reveals predominance of Erg11 Y132F alteration among azole-resistant Candida parapsilosis and Candida tropicalis and country-specific isolate dissemination. 61
31520783 2020
37
On the path to gold: Monoanionic Au bisdithiolate complexes with antimicrobial and antitumor activities. 61
31671298 2020
38
Role of major facilitator superfamily transporter Qdr2p in biofilm formation by Candida glabrata. 61
31519064 2019
39
Prevalence, risk factors and antifungal susceptibility pattern of Candida species among pregnant women at Debre Markos Referral Hospital, Northwest Ethiopia. 61
31888537 2019
40
Efficacy of a propolis solution for cleaning complete dentures. 61
31920057 2019
41
Iontophoresis enhances voriconazole antifungal potency and corneal penetration. 61
31884059 2019
42
Inhibition-Disruption of Candida glabrata Biofilms: Symmetrical Selenoesters as Potential Anti-Biofilm Agents. 61
31835290 2019
43
Deletion of CDR1 reveals redox regulation of pleiotropic drug resistance in Candida glabrata. 61
31843579 2019
44
A new inducible CRISPR-Cas9 system useful for genome editing and study of double-strand break repair in Candida glabrata. 61
31423617 2019
45
Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme. 61
30724625 2019
46
Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine. 61
30727781 2019
47
The underestimated problem of oral Candida colonization-An observational pilot study in one nursing home. 61
31890306 2019
48
Heterologous expression and functional analysis of the F-box protein Ucc1 from other yeast species in Saccharomyces cerevisiae. 61
31253511 2019
49
Gastrointestinal Disease Associated with Non-albicans Candida Species in Six Birds. 61
31833310 2019
50
Molecular studies of NAD- and NADP-glutamate dehydrogenases decipher the conundrum of yeast-hypha dimorphism in zygomycete Benjaminiella poitrasii. 61
31644791 2019

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 RBPJ IFNG
2 10.09 IFNG CSF2

GO Terms for Candida Glabrata

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.63 RBPJ HTN3 HTN1
2 killing of cells of other organism GO:0031640 9.43 HTN3 HTN1
3 regulation of cell proliferation GO:0042127 9.43 SQLE RBPJ CSF2
4 cholesterol biosynthetic process GO:0006695 9.4 SQLE LSS
5 biomineral tissue development GO:0031214 9.37 HTN3 HTN1
6 regulation of cholesterol biosynthetic process GO:0045540 9.32 SQLE LSS
7 defense response to fungus GO:0050832 9.16 HTN3 HTN1
8 myeloid dendritic cell differentiation GO:0043011 8.96 RBPJ CSF2
9 positive regulation of interleukin-23 production GO:0032747 8.62 IFNG CSF2

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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