MCID: CND006
MIFTS: 37

Candida Glabrata

Categories: Rare diseases

Aliases & Classifications for Candida Glabrata

MalaCards integrated aliases for Candida Glabrata:

Name: Candida Glabrata 54

Classifications:



Summaries for Candida Glabrata

MalaCards based summary : Candida Glabrata is related to candidiasis and oral candidiasis. An important gene associated with Candida Glabrata is DHFR (Dihydrofolate Reductase), and among its related pathways/superpathways are Th2 Differentiation Pathway and Cytokines and Inflammatory Response. The drugs Micafungin and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include testes, neutrophil and colon, and related phenotypes are hematopoietic system and immune system

Wikipedia : 77 Candida glabrata is a species of haploid yeast of the genus Candida, previously known as Torulopsis... more...

Related Diseases for Candida Glabrata

Diseases related to Candida Glabrata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 candidiasis 30.4 APCS HTN3 IFNG SKAP2
2 oral candidiasis 30.3 HTN3 SKAP2
3 endocarditis 10.4
4 endophthalmitis 10.4
5 vaginitis 10.4
6 osteomyelitis 10.3
7 vulvovaginal candidiasis 10.3
8 chorioamnionitis 10.3
9 peritonitis 10.3
10 large granular lymphocyte leukemia 10.3 CSF2 IFNG
11 trichosporonosis 10.3 CSF2 IFNG
12 arthritis 10.3
13 mucormycosis 10.3 CSF2 IFNG
14 carotid artery thrombosis 10.2 CSF2 IFNG
15 human t-cell leukemia virus type 2 10.2 CSF2 IFNG
16 meconium aspiration syndrome 10.2 CSF2 IFNG
17 cyclic neutropenia 10.2 CSF2 IFNG
18 cytomegalovirus retinitis 10.2 CSF2 IFNG
19 tetralogy of fallot 10.2
20 esophagitis 10.2
21 vulvovaginitis 10.2
22 pneumonia 10.2
23 meningitis 10.2
24 cryptococcal meningitis 10.2 CSF2 IFNG
25 smallpox 10.1 CSF2 IFNG
26 multiple sclerosis 10.1
27 neutrophil actin dysfunction 10.1
28 colitis 10.1
29 denture stomatitis 10.1
30 cholecystitis 10.1
31 stomatitis 10.1
32 hypoxia 10.1
33 langerhans cell histiocytosis 10.1 CSF2 IFNG
34 parasitic protozoa infectious disease 10.0 DHFR IFNG
35 opportunistic mycosis 10.0 IFNG SKAP2
36 keratitis, hereditary 10.0
37 marfan syndrome 10.0
38 amyotrophic lateral sclerosis 3 10.0
39 pulmonary disease, chronic obstructive 10.0
40 chronic granulomatous disease 10.0
41 diabetes mellitus 10.0
42 hematopoietic stem cell transplantation 10.0
43 keratopathy 10.0
44 leukemia 10.0
45 neutropenia 10.0
46 spinal cord injury 10.0
47 aspiration pneumonia 10.0
48 infective endocarditis 10.0
49 lymphoma 10.0
50 thrombosis 10.0

Graphical network of the top 20 diseases related to Candida Glabrata:



Diseases related to Candida Glabrata

Symptoms & Phenotypes for Candida Glabrata

MGI Mouse Phenotypes related to Candida Glabrata:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 APCS CSF2 DHFR IFNG RBPJ RIF1
2 immune system MP:0005387 9.56 APCS CSF2 DHFR IFNG RBPJ RIF1
3 mortality/aging MP:0010768 9.28 APCS CSF2 DHFR IFNG LSS RBPJ

Drugs & Therapeutics for Candida Glabrata

Drugs for Candida Glabrata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Micafungin Approved, Investigational Phase 4 235114-32-6 477468 3081921
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Caspofungin Approved Phase 4 162808-62-0, 179463-17-3 2826718 468682
4
Voriconazole Approved, Investigational Phase 4 137234-62-9 71616
5
Fluconazole Approved, Investigational Phase 4 86386-73-4 3365
6
Anidulafungin Approved, Investigational Phase 4 166663-25-8 166548
7 Echinocandins Phase 4
8 Antifungal Agents Phase 4
9 Anti-Infective Agents Phase 4,Not Applicable
10 Hormones Phase 4
11 Hormone Antagonists Phase 4
12 Steroid Synthesis Inhibitors Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Cytochrome P-450 CYP2C9 Inhibitors Phase 4
15 Cytochrome P-450 CYP3A Inhibitors Phase 4
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
17 Cytochrome P-450 CYP2C19 Inhibitors Phase 4
18
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
19 Disinfectants Not Applicable
20 chloramine-T Not Applicable
21 Anti-Infective Agents, Local Not Applicable
22 Eusol Not Applicable
23 Pharmaceutical Solutions Not Applicable
24 Sodium hypochlorite Not Applicable
25 Castor Not Applicable
26 Brewer's Yeast Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins Completed NCT00839540 Phase 4 micafungin;Micafungin;Caspofungin
2 Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis Completed NCT00496197 Phase 4 Eraxis (anidulafungin);Diflucan (fluconazole);Vfend (voriconazole)
3 Clinical Conditions and Prevalence of Periodontopathogens in Smokers and Non-smokers After Periodontal Therapy Unknown status NCT02581319 Not Applicable
4 Clinical and Laboratorial Evaluation of the Desinfection Solutions in Candida Species From Total Prostheses and Palate of Total Edentulous. Completed NCT03203551 Not Applicable
5 Candidemia in a Pediatric Center and Importance of Central Venous Catheter Removal Completed NCT02088476
6 Study of Innate Host Immune Response to C. Glabrata Clinical Isolates Resistant to Echinocandins: Impact on the Management of Candidemia in High-risk Patients Active, not recruiting NCT03652194
7 Retrospective Chart Review of Candida Fungemia Active, not recruiting NCT03827330
8 Effect of Saccharomyces Cerevisiae on Vulvo-vaginal Candidiasis Terminated NCT02859493 Not Applicable

Search NIH Clinical Center for Candida Glabrata

Genetic Tests for Candida Glabrata

Anatomical Context for Candida Glabrata

MalaCards organs/tissues related to Candida Glabrata:

42
Testes, Neutrophil, Colon, Heart, Endothelial, Monocytes, Bone Marrow

Publications for Candida Glabrata

Articles related to Candida Glabrata:

(show top 50) (show all 1034)
# Title Authors Year
1
Candida glabrata-Induced Refractory Infectious Arthritis: A Case Report and Literature Review. ( 30903581 )
2019
2
Analysis of antifungal resistance genes in Candida albicans and Candida glabrata using next generation sequencing. ( 30629653 )
2019
3
Letter to Habets JGV et al. on "A rare case of Candida glabrata spondylodiscitis: case report and literature review". ( 30634040 )
2019
4
CgHog1-Mediated CgRds2 Phosphorylation Alters Glycerophospholipid Composition To Coordinate Osmotic Stress in Candida glabrata. ( 30635387 )
2019
5
Missense mutation in CgPDR1 regulator associated with azole-resistant Candida glabrata recovered from Thai oral candidiasis patients. ( 30658200 )
2019
6
Candidaemia in an Irish intensive care unit setting between 2004 and 2018 reflects increased incidence of Candida glabrata. ( 30668957 )
2019
7
Vacuolar proton-translocating ATPase is required for antifungal resistance and virulence of Candida glabrata. ( 30673768 )
2019
8
Benzenesulfonamides incorporating nitrogenous bases show effective inhibition of β-carbonic anhydrases from the pathogenic fungi Cryptococcus neoformans, Candida glabrata and Malassezia globosa. ( 30684862 )
2019
9
Bioimmunological activities of Candida glabrata cellular mannan. ( 30689830 )
2019
10
Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by α-asarone-based synthetic compounds as antifungal agents. ( 30690093 )
2019
11
Inflammatory Cell Recruitment in Candida glabrata Biofilm Cell-Infected Mice Receiving Antifungal Chemotherapy. ( 30691087 )
2019
12
Candida glabrata: A Lot More Than Meets the Eye. ( 30704135 )
2019
13
Autophagy-Inducing Factor Atg1 Is Required for Virulence in the Pathogenic Fungus Candida glabrata. ( 30761093 )
2019
14
Sugar Sensing and Signaling in Candida albicans and Candida glabrata. ( 30761119 )
2019
15
Efficacy of liposomal amphotericin B and anidulafungin using an antifungal lock technique (ALT) for catheter-related Candida albicans and Candida glabrata infections in an experimental model. ( 30779771 )
2019
16
Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata. ( 30808979 )
2019
17
Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations. ( 30809200 )
2019
18
Expression of ERG11 and efflux pump genes CDR1, CDR2 and SNQ2 in voriconazole susceptible and resistant Candida glabrata strains. ( 30843047 )
2019
19
Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection. ( 30854392 )
2019
20
Enhanced Pyruvate Production in Candida glabrata by Engineering ATP Futile Cycle System. ( 30856339 )
2019
21
Genome-Wide Response to Drugs and Stress in the Pathogenic Yeast Candida glabrata. ( 30911893 )
2019
22
In Vitro Activity of a Novel Antifungal Compound, MYC-053, against Clinically Significant Antifungal-Resistant Strains of Candida glabrata, Candida auris, Cryptococcus neoformans, and Pneumocystis spp. ( 30917977 )
2019
23
Low level of antifungal resistance in Iranian isolates of Candida glabrata recovered from blood samples from multicenter (2015-2018): Potential prognostic values of genotyping and sequencing of PDR1. ( 30936110 )
2019
24
Candida glabrata Has No Enhancing Role in the Pathogenesis of Candida-Associated Denture Stomatitis in a Rat Model. ( 30944214 )
2019
25
Computational inference of the transcriptional regulatory network of Candida glabrata. ( 31034021 )
2019
26
Atomic Force Microscopy Demonstrates that Candida glabrata Uses Three Epa Proteins To Mediate Adhesion to Abiotic Surfaces. ( 31043520 )
2019
27
The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin on Candida Albicans and Candida Glabrata. ( 31049082 )
2019
28
The regulation of iron homeostasis in the fungal human pathogen Candida glabrata. ( 31050635 )
2019
29
Understand the Genomic Diversity and Evolution of Fungal Pathogen Candida glabrata by Genome-wide Analysis of Genetic Variations. ( 31059831 )
2019
30
Comparison of fks gene mutations and minimum inhibitory concentrations for the detection of Candida glabrata resistance to micafungin: a systematic review and meta-analysis. ( 31077631 )
2019
31
Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata. ( 31101845 )
2019
32
Two-stage revision and systemic antifungal therapy of Candida glabrata primary prosthetic hip infection successfully treated: a case report. ( 31109363 )
2019
33
Resistance to echinocandin antifungal agents in the United Kingdom in clinical isolates of Candida glabrata: Fifteen years of interpretation and assessment. ( 31111912 )
2019
34
In vitro synergy with fluconazole plus doxycycline or tigecycline against clinical Candida glabrata isolates. ( 29618039 )
2019
35
Genomes shed light on the secret life of Candida glabrata: not so asexual, not so commensal. ( 30027485 )
2019
36
Multiple interfaces control activity of the Candida glabrata Pdr1 transcription factor mediating azole drug resistance. ( 30056490 )
2019
37
A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate. ( 30348666 )
2019
38
Spontaneous Mutational Frequency and FKS Mutation Rates Vary by Echinocandin Agent against Candida glabrata. ( 30373796 )
2019
39
MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata. ( 30397068 )
2019
40
Monitoring of Fluconazole and Caspofungin Activity against In Vivo Candida glabrata Biofilms by Bioluminescence Imaging. ( 30420485 )
2019
41
ERG6 and ERG2 Are Major Targets Conferring Reduced Susceptibility to Amphotericin B in Clinical Candida glabrata Isolates in Kuwait. ( 30455247 )
2019
42
Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy. ( 30478162 )
2019
43
Corrigendum: Candida glabrata: Emerging pathogen of candiduria in hospitalized patients with heart disorders. ( 30535011 )
2019
44
Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: a case report. ( 30594147 )
2018
45
Spatial modulation and cofactor engineering of key pathway enzymes for fumarate production in Candida glabrata. ( 30582631 )
2018
46
High diversity of Candida glabrata in a tertiary hospital-Mwanza, Tanzania. ( 30597052 )
2018
47
Effect of Acetic Acid and Lactic Acid at Low pH in Growth and Azole Resistance of Candida albicans and Candida glabrata. ( 30671051 )
2018
48
Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review. ( 29164434 )
2018
49
Carboxymethylated ɩ-carrageenan conjugated amphotericin B loaded gelatin nanoparticles for treating intracellular Candida glabrata infections. ( 29169943 )
2018
50
Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata. ( 29177447 )
2018

Variations for Candida Glabrata

Expression for Candida Glabrata

Search GEO for disease gene expression data for Candida Glabrata.

Pathways for Candida Glabrata

Pathways related to Candida Glabrata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 IFNG RBPJ
2 10.09 CSF2 IFNG

GO Terms for Candida Glabrata

Cellular components related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 APCS CSF2 HTN1 HTN3 IFNG TPSAB1

Biological processes related to Candida Glabrata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.61 HTN1 HTN3 RBPJ
2 humoral immune response GO:0006959 9.48 IFNG RBPJ
3 antimicrobial humoral response GO:0019730 9.46 HTN1 HTN3
4 cholesterol biosynthetic process GO:0006695 9.4 LSS SQLE
5 killing of cells of other organism GO:0031640 9.37 HTN1 HTN3
6 biomineral tissue development GO:0031214 9.32 HTN1 HTN3
7 regulation of cholesterol biosynthetic process GO:0045540 9.26 LSS SQLE
8 defense response to fungus GO:0050832 9.16 HTN1 HTN3
9 myeloid dendritic cell differentiation GO:0043011 8.96 CSF2 RBPJ
10 positive regulation of interleukin-23 production GO:0032747 8.62 CSF2 IFNG

Sources for Candida Glabrata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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