Candidiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CND004 MIFTS: 60	Candidiasis Categories: Blood diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Oral diseases, Rare diseases, Reproductive diseases, Skin diseases
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Aliases & Classifications for Candidiasis

MalaCards integrated aliases for Candidiasis:

Name: Candidiasis ¹² ⁷⁶ ⁵⁵ ³ ⁴⁴ ¹⁵ ⁷³

Systemic Candidiasis ¹² ⁵³ ⁷³

Invasive Candidiasis ⁵³ ³ ⁷³

Disseminated Candidiasis ¹² ⁵⁵

Systemic Candida Infections ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases Genetic diseases
Anatomical: Blood diseases Neuronal diseases Reproductive diseases Oral diseases Skin diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Mycoses

Candidiasis

Candidiasis, unspecified

External Ids:

Disease Ontology ¹² DOID:1508

ICD10 ³³ B37 B37.9

ICD9CM ³⁵ 112 112.9

MeSH ⁴⁴ D002177

NCIt ⁵⁰ C26711

SNOMED-CT ⁶⁸ 78048006

UMLS ⁷³ C0006840 C0153252 C1609535

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Summaries for Candidiasis

NIH Rare Diseases : ⁵³ Systemic candidiasis includes a spectrum of yeast infections caused by different species (types) of Candida. It is a serious infection that can affect the blood, heart, brain, eyes, bones, or other parts of the body. Although there are over 200 species of Candida, five different species of Candida cause 90% of systemic candidiasis. The most common form of this invasive yeast infection is when Candida enters the bloodstream (candidemia). Signs of candidemia include fever and chills that do not improve with antibiotics. Symptoms of other types of systemic candidiasis depend on the organ or system which is infected. Systemic candidiasis is the most common fungal infection among hosptilized people in high-income countries, including the United States. Diagnosis can be difficult, especially when the Candida is not found in the bloodstream. Treatment usually includes consists of oral or intravenous (IV) antifungal medications.

MalaCards based summary : Candidiasis, also known as systemic candidiasis, is related to candidiasis, familial, 2 and oral candidiasis. An important gene associated with Candidiasis is AIRE (Autoimmune Regulator), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Fluconazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and heart, and related phenotypes are hematopoietic system and digestive/alimentary

Disease Ontology : ¹² An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons.

CDC : ³ Photomicrograph of the fungus Candida albicans

Wikipedia : ⁷⁶ Candidiasis is a fungal infection due to any type of Candida (a type of yeast). When it affects the... more...

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Related Diseases for Candidiasis

Diseases in the Candidiasis family:

Candidiasis, Familial, 1	Candidiasis, Familial, 2
Candidiasis, Familial, 3	Candidiasis, Familial, 4
Candidiasis, Familial, 6	Candidiasis, Familial, 8
Candidiasis, Familial, 9	Familial Candidiasis

Diseases related to Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 336)

#	Related Disease	Score	Top Affiliating Genes
1	candidiasis, familial, 2	34.2	CARD9 CLEC7A
2	oral candidiasis	34.1	DEFB4A HTN3 SKAP2
3	familial candidiasis	33.7	CANDF1 CANDN1 CARD9 IL17F IL17RA
4	chronic mucocutaneous candidiasis	33.1	AIRE CARD9 CLEC7A IFNG IL10 IL17A
5	aspergillosis	30.7	CLEC7A IFNG IL10
6	cryptococcosis	30.3	CARD9 IFNG PLB1
7	candida glabrata	30.3	APCS HTN3 IFNG SKAP2
8	alopecia areata	30.0	AIRE IFNG IL17A
9	viral infectious disease	30.0	IFNG IL10 STAT1
10	sporotrichosis	29.9	IFNG IL10
11	trichosporonosis	29.8	IFNG IL17A
12	myasthenia gravis	29.8	AIRE IFNG IL10
13	psoriasis	29.7	DEFB4A IFNG IL10 IL17A TRAF3IP2
14	autoimmune disease	29.6	AIRE IFNG IL10 IL17A
15	neurosyphilis	29.6	IL10 IL17A
16	hematopoietic stem cell transplantation	29.6	CLEC7A IFNG IL10
17	coccidioidomycosis	29.6	CARD9 CLEC7A IL10 STAT1
18	uveitis	29.5	IFNG IL10 IL17A
19	human immunodeficiency virus type 1	29.2	APCS HSP90AA1 HTN3 IFNG IL10 STAT1
20	vulvovaginal candidiasis	12.7
21	neonatal candidiasis	12.5
22	esophageal candidiasis	12.5
23	candidiasis, familial, 4	12.5
24	cutaneous candidiasis	12.4
25	candidiasis, familial, 6	12.4
26	candidiasis, familial, 8	12.4
27	candidiasis, familial, 1	12.4
28	candidiasis, familial, 9	12.3
29	autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	12.1
30	candidiasis, familial, 3	12.1
31	autoimmune polyendocrine syndrome type 1	12.0
32	immunodeficiency 51	11.9
33	candidal paronychia	11.8
34	immunodeficiency 31c	11.8
35	vaginitis	11.3
36	myeloperoxidase deficiency	11.3
37	median rhomboid glossitis	11.3
38	biotinidase deficiency	11.2
39	immunodeficiency 42	11.1
40	immunodeficiency 32b	10.9
41	reticular dysgenesis	10.9
42	autoimmune polyendocrine syndrome, type ii	10.9
43	severe combined immunodeficiency, x-linked	10.9
44	t-cell receptor-alpha/beta deficiency	10.9
45	immunodeficiency 26 with or without neurologic abnormalities	10.9
46	aids dysmorphic syndrome	10.9
47	immunodeficiency with thymoma	10.9
48	bacterial vaginosis	10.4
49	trichomoniasis	10.3
50	human immunodeficiency virus infectious disease	10.3

Comorbidity relations with Candidiasis via Phenotypic Disease Network (PDN): (show all 13)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Chronic Kidney Failure
Decubitus Ulcer	Deficiency Anemia
Familial Atrial Fibrillation	Heart Disease
Hydronephrosis	Intestinal Obstruction
Paralytic Ileus	Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Candidiasis:

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Symptoms & Phenotypes for Candidiasis

MGI Mouse Phenotypes related to Candidiasis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.93	AIRE APCS CARD9 CLEC7A IFNG IL10
2	digestive/alimentary	MP:0005381	9.86	AIRE CLEC7A IFNG IL10 IL17A IL17F
3	immune system	MP:0005387	9.8	AIRE APCS CARD9 CLEC7A HSP90AA1 IFNG
4	respiratory system	MP:0005388	9.23	AIRE CLEC7A IFNG IL10 IL17A IL17F

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Drugs & Therapeutics for Candidiasis

Drugs for Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 298)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fluconazole

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

86386-73-4

3365

Miconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

22916-47-8

4189

Anidulafungin

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

166663-25-8

166548

Clindamycin

Approved, Vet_approved

Phase 4,Phase 3,Early Phase 1,Not Applicable

18323-44-9

29029

Clotrimazole

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

23593-75-1

2812

Fluticasone

Approved, Experimental

Phase 4,Phase 3,Phase 2

90566-53-3

62924

Amphotericin B

Approved, Investigational

Phase 4,Phase 3,Phase 2,Not Applicable

1397-89-3

5280965 14956

Micafungin

Approved, Investigational

Phase 4,Phase 2,Phase 3,Phase 1

235114-32-6

3081921 477468

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Caspofungin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

179463-17-3, 162808-62-0

468682 2826718

Dequalinium

Approved, Investigational

Phase 4

6707-58-0

Voriconazole

Approved, Investigational

Phase 4,Phase 3,Phase 2,Phase 1

137234-62-9

71616

Terconazole

Approved

Phase 4,Phase 3,Not Applicable,Early Phase 1

67915-31-5

441383

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Nystatin

Approved, Vet_approved

Phase 4,Phase 3,Phase 2,Not Applicable

1400-61-9

11953884

Metronidazole

Approved

Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable

443-48-1

4173

Zinc

Approved, Investigational

Phase 4

7440-66-6

Ritonavir

Approved, Investigational

Phase 4,Phase 3,Phase 2

155213-67-5

392622

Emtricitabine

Approved, Investigational

Phase 4

143491-57-0

60877

Nevirapine

Approved

Phase 4

129618-40-2

4463

Methotrexate

Approved

Phase 4,Phase 3

59-05-2, 1959-05-2

126941

Histamine

Approved, Investigational

Phase 4,Phase 2

51-45-6, 75614-87-8

774

Simethicone

Approved

Phase 4,Phase 3

8050-81-5

Aluminum hydroxide

Approved, Investigational

Phase 4,Phase 1,Phase 2

21645-51-2

Posaconazole

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2

171228-49-2

147912

Itraconazole

Approved, Investigational

Phase 4,Phase 3,Phase 1,Not Applicable

84625-61-6

55283

Isoniazid

Approved, Investigational

Phase 4

54-85-3

3767

Efavirenz

Approved, Investigational

Phase 4

154598-52-4

64139

Zidovudine

Approved

Phase 4

30516-87-1

35370

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Povidone

Approved

Phase 4

9003-39-8

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Magnesium hydroxide

Approved, Investigational

Phase 4

1309-42-8

Mycophenolic acid

Approved

Phase 4,Phase 3

24280-93-1

446541

Ciclopirox

Approved, Investigational

Phase 4

29342-05-0

2749

Prednisone

Approved, Vet_approved

Phase 4

53-03-2

5865

Castor oil

Approved, Investigational, Nutraceutical, Vet_approved

Phase 4

8001-79-4

Tenofovir

Experimental, Investigational

Phase 4

147127-20-6

464205

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Cytochrome P-450 Enzyme Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Steroid Synthesis Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Antifungal Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Cytochrome P-450 CYP2C19 Inhibitors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Hormones

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Hormone Antagonists

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 352)

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week	Unknown status	NCT00537888	Phase 4	fluconazole
2	A Pilot Study for the Use of Biomarkers and Early Treatment of Invasive Candidiasis in Intensive Care Unit (ICU) Patients	Unknown status	NCT01734525	Phase 4	Anidulafungin
3	Use of Boric Acid in Combination With Probiotics for the Treatment of Vaginal Infections	Unknown status	NCT02860845	Phase 4	Antibiotic (Clindamycin);Antifungal (Clotrimazole)
4	Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID	Unknown status	NCT00235053	Phase 4	fluticasone/salmeterol DISKUS 250/50
5	Epidemiological Study About the Evolution of Patients Treated for an Acute Episode of Vulvovaginal Candidiasis	Completed	NCT02248506	Phase 4
6	An Efficacy and Safety Study of Miconazole and Hydrocortisone Cream in the Treatment of Vulvar Candidiasis	Completed	NCT01769339	Phase 4	Miconazole plus Hydrocortisone
7	Randomized Study of Caspofungin Prophylaxis Followed by Pre-emptive Therapy for Invasive Candidiasis in the Intensive Care Unit (ICU)	Completed	NCT00520234	Phase 4	Caspofungin;Normal Saline
8	Single Dose Versus Two Weeks Course of Fluconazole in the Treatment of Oropharyngeal Candidiasis in HIV Infected Individuals in Tanzania	Completed	NCT00553137	Phase 4	fluconazole;fluconazole
9	Comparative Efficacy Study of 10 mg Dequalinium Chloride (Fluomizin) in the Treatment of Vulvovaginal Candidiasis	Completed	NCT02242695	Phase 4	Fluomizin vaginal tablets;Canesten vaginal tablets
10	Clotrimazole Vaginal Tablet vs Fluconazole for Severe Vulvovaginal Candidiasis	Completed	NCT02180828	Phase 4	Clotrimazole vaginal tablet;Fluconazole
11	Study Will Evaluate The Safety And Efficacy Of Anidulafungin In Patients With Candidemia Or Invasive Candidiasis	Completed	NCT00496197	Phase 4	Eraxis (anidulafungin);Diflucan (fluconazole);Vfend (voriconazole)
12	This Is An Open-Label, Non-Comparative Study Designed To Evaluate A Short Course Of IV Anidulafungin, Followed Optionally By Oral Voriconazole, For The Treatment Of Candidemia And Invasive Candidiasis	Completed	NCT00548262	Phase 4	Anidulafungin;Voriconazole
13	CRITIC - Treatment of Candidemia and Invasive Candidiasis	Completed	NCT00670657	Phase 4	AmBisome
14	Terconazole Vaginal Suppository vs Fluconazole for the Treatment of Severe Vulvovaginal Candidiasis	Completed	NCT02180100	Phase 4	Terconazole Vaginal Suppository;Fluconazole
15	A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients With Recurrent Thrush	Completed	NCT00000951	Phase 4	Fluconazole
16	Fluconazole Prophylaxis of Thrush in AIDS	Completed	NCT00001542	Phase 4	fluconazole
17	Optimal Dosage of Caspofungin in Critically Ill Patients	Completed	NCT01994096	Phase 4	Caspofungin
18	Pharmacokinetics of Micafungin in Patients of Intensive Care Units	Completed	NCT02164890	Phase 4
19	Prospective Two-Year Study to Assess Miconazole Nitrate Resistance in Neonates and Infants	Completed	NCT00702507	Phase 4	0.25 % Miconazole Nitrate Ointment
20	Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants	Completed	NCT00001107	Phase 4	Fluconazole;AmBisome
21	Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina	Completed	NCT00194324	Phase 4	Miconazole nitrate
22	Effectiveness of Hygiene Solutions on Denture Biofilm	Completed	NCT02407834	Phase 4
23	A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections	Completed	NCT00647907	Phase 4	Voriconazole
24	Antifungal Prophylaxis in Intensive Care Unit (ICU) Patients	Completed	NCT01495039	Phase 4	Nystatin
25	Micafungin Pharmacokinetics in Obese Patients	Completed	NCT03102658	Phase 4	Micafungin
26	Anidulafungin Pharmacokinetics Given as a Single Intravenous Dose to Obese Patients (ADOPT)	Completed	NCT02021123	Phase 4	Anidulafungin 100mg single dose iv
27	Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration	Completed	NCT02651038	Phase 4	Micafungin
28	Lactoserum (Dermacyd Femina®) and Prevention of Recurrence of Bacterial Vaginosis	Completed	NCT00556179	Phase 4	Lactoserum (Dermacyd Femina®)
29	Comparison of Lactobacillus Reuteri and Nystatin Prophylaxis on Candida Colonization and Infection in Very Low Birth Weight Infants	Completed	NCT01531192	Phase 4	Nystatin
30	Glucose Control for Glucocorticoid Induced Hyperglycemia During Chemotherapy	Completed	NCT02155374	Phase 4	Sliding scale insulin;Intermediate acting insulin;Glucose lowering medication;Chemotherapy
31	Comparison of Two Topical Formulations Containing Clindamycin and Clotrimazole in Patients With Vaginal Infections	Completed	NCT01697826	Phase 4	ClinSupV3 -soft gelatin capsule;ClinSupV3ER- Extended release tablet
32	Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins	Completed	NCT00839540	Phase 4	micafungin;Micafungin;Caspofungin
33	A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects	Completed	NCT00940017	Phase 4	anidulafungin and voriconazole
34	Nevirapine vs. Atazanavir Boosted With Ritonavir on a Background of Truvada in Human Immunodeficiency Virus (HIV) Infected Naive Patients (NEwArT)	Completed	NCT00552240	Phase 4	tenofovir DF 300 mg QD;tenofovir DF 300 mg QD;emtricitabine 200 mg QD;emtricitabine 200 mg QD;Nevirapine 200 mg BID;Atazanavir 300 mg;Ritonavir 100 mg
35	Package of Care to Improve Retention in ART and Mortality Among Treatment Naive HIV Infected Individuals	Recruiting	NCT03723525	Phase 4
36	Gelclair at Conditioning or After Oral Mucositis Diagnosed vs. Magic Mouth Wash in Stem Cell Transplant Recipients	Recruiting	NCT03490396	Phase 4
37	Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants	Not yet recruiting	NCT03717623	Phase 4	Posaconazole pharmacokinetics
38	A Study to Evaluate the Efficacy and Safety of Micafungin Against Invasive Candidiasis or Candidemia	Terminated	NCT01982071	Phase 4	Micafungin
39	Post Marketing Study to Evaluate the Safety and Efficacy of Micafungin Against Fungal Infections Caused by Candida Spp or Aspergillus Spp	Terminated	NCT02646800	Phase 4	Micafungin
40	Safety Study of Ciclopirox Olamine Cream for Dermatomycoses in Children	Terminated	NCT01646580	Phase 4	ciclopirox
41	Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients	Terminated	NCT01282879	Phase 4	Itraconazole
42	Fluconazole Versus Micafungin for Candida Bloodstream Infection in Non-Neutropenic Patients	Withdrawn	NCT00304772	Phase 4	Fluconazole;Micafungin
43	RCT of Postoperative Infections Following Caesarean Section Infections Following Caesarean Section	Withdrawn	NCT02009098	Phase 4	Cefuroxime
44	Fluconazole Versus Micafungin in Neonates With Candidiasis	Unknown status	NCT02145832	Phase 2, Phase 3	Fluconazole;Micafungin
45	Evaluate Efficacy, Tolerability & Safety of Combination of Clindamycin and Ketoconazole for the Treatment of Mixed-Type Vaginosis, Bacterial Vaginosis and Candidiasis	Unknown status	NCT00889356	Phase 3	Clindamycin 100mg and Ketoconazole 400mg;Tetracycline 100mg and Amphotericin B 50mg
46	Dysbiosis in Localized Provoked Vulvodynia (LPV)	Unknown status	NCT02393911	Phase 3
47	Efficacy of Interferon-gamma in Combination With Anidulafungin for the Treatment of Candidemia	Unknown status	NCT01270490	Phase 3	Interferon-gamma, Recombinant
48	Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight	Completed	NCT00734539	Phase 3	fluconazole;placebo
49	A Comparison of Gentian Violet (GV) Mouth Washes, Nystatin, and Ketoconazole Tabs in Treating Oropharyngeal Candidiasis	Completed	NCT00128323	Phase 3	Gentian violet 1% solution;Gentian violet 0.00165% solution;Nystatin solution
50	Comparative Trial of Micafungin Versus Fluconazole for Treating Esophageal Candidiasis	Completed	NCT00666185	Phase 3	Micafungin;Fluconazole

Search NIH Clinical Center for Candidiasis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :

flucytosine

Cochrane evidence based reviews: candidiasis

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Genetic Tests for Candidiasis

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Anatomical Context for Candidiasis

MalaCards organs/tissues related to Candidiasis:

⁴¹

Skin, Brain, Heart, Testes, Colon, Bone, Liver

Sources

Publications for Candidiasis

Articles related to Candidiasis:

(show top 50) (show all 2877)

#	Title	Authors	Year
1	Genotyping of Candida albicans and Candida dubliniensis by 25S rDNA analysis shows association with virulence attributes in oral candidiasis. ( 30321765 )	Tantivitayakul P...Lapirattanakul J	2019
2	Prospective evaluation of lymphocyte subtyping for the diagnosis of invasive candidiasis in non-neutropenic critically ill patients. ( 30399447 )	Zhang J...Xiao M	2019
3	Long-Term Outcomes of Women With Recurrent Vulvovaginal Candidiasis After a Course of Maintenance Antifungal Therapy. ( 29975334 )	Crouss T....Nyirjesy P.	2018
4	New evidence on oral L. plantarum P17630 product in women with history of recurrent vulvovaginal candidiasis (RVVC): a randomized double-blind placebo-controlled study. ( 29364495 )	Vladareanu R....Vladareanu S.	2018
5	Experience with I^-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study. ( 29910549 )	Bansal N....Ramasubramanian V.	2018
6	Risk Factors of Vulvovaginal Candidiasis among Women of Reproductive Age in Xi'an: A Cross-Sectional Study. ( 29977925 )	Zeng X....An R.	2018
7	Risk of major congenital malformations following first-trimester exposure to vaginal azoles used for treating vulvovaginal candidiasis: a population-based retrospective cohort study. ( 29790255 )	Rotem R....Levy A.	2018
8	Course of Esophageal Candidiasis and Outcomes of Patients at a Single Center. ( 29702297 )	Hoversten P....Katzka D.A.	2018
9	Caspofungin resistant disseminated candidiasis in a 7-year-old girl with T cell lymphoma: a case report. ( 29441283 )	Schmalz M....Feinberg A.	2018
10	Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis. ( 29462298 )	Tasaki S....Tanaka Y.	2018
11	A phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate theA efficacy and safety of orally administeredA VT-1161 inA the treatment of recurrentA vulvovaginal candidiasis. ( 29534874 )	Brand S.R....Tavakkol A.	2018
12	Antifungal activity of clinical Lactobacillus strains against Candida albicans biofilms: identification of potential probiotic candidates to prevent oral candidiasis. ( 29380647 )	Rossoni R.D....Junqueira J.C.	2018
13	Clinical characteristics of the first cases of invasive candidiasis in China due to pan-echinocandin-resistant<i>Candida tropicalis</i>and<i>Candida glabrata</i>isolates with delineation of their resistance mechanisms. ( 29416360 )	Xiao M....Xu Y.C.	2018
14	Antifungal Susceptibility and Clinical Outcome in Neonatal Candidiasis. ( 29369937 )	Autmizguine J....Benjamin D.K.	2018
15	VT-1598 inhibits the in vitro growth of mucosal Candida strains and protects against fluconazole-susceptible and -resistant oral candidiasis in IL-17 signalling-deficient mice. ( 29788070 )	Break T.J....Lionakis M.S.	2018
16	Cytology Preparations of Formalin Fixative Aid Detection of Giardia in Duodenal Biopsy Samples: A Helpful Tool for Diagnosing Esophageal Candidiasis as Well? ( 29762142 )	SchrAPder S....GA1nther T.	2018
17	Pulsatilla decoction inhibits Candida albicans proliferation and adhesion in a mouse model of vulvovaginal candidiasis via the Dectin-1 signaling pathway. ( 29775695 )	Yang L....Luo S.	2018
18	Two Cases of Chronic Candidiasis in Keratitis-Ichthyosis-Deafness Syndrome. ( 29742560 )	Bartenstein D....Hussain S.	2018
19	Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis. ( 29963049 )	Uppuluri P....Ibrahim A.S.	2018
20	Surface-modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis. ( 28986195 )	Kenechukwu F.C....Akpa P.A.	2018
21	Predictors of esophageal candidiasis among patients attending endoscopy unit in a tertiary hospital, Tanzania: a retrospective cross-sectional study. ( 29977259 )	Mushi M.F....Mshana S.E.	2018
22	Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: &quot;Neutrophil Anergy&quot;. ( 29203543 )	Yano J....Fidel P.L.	2018
23	Chronic mucocutaneous candidiasis due to gain-of-function mutation in STAT1. ( 29702748 )	Carey B....Hodgson T.	2018
24	Economic evaluation of micafungin versus liposomal amphotericin B (LAmB) for treating patients with candidaemia and invasive candidiasis (IC) in Turkey. ( 29959610 )	Neoh C.F....Kong D.C.M.	2018
25	Antifungal susceptibilities, in vitro production of virulence factors and activities of ceragenins against Candida spp. isolated from vulvovaginal candidiasis. ( 29846682 )	Hacioglu M....Tan A.S.B.	2018
26	Cutaneous candidiasis caused by Candida albicans in a young non-immunosuppressed patient: an unusual presentation. ( 29882446 )	Palese E....Panasiti V.	2018
27	Diagnosing Invasive Candidiasis. ( 29444828 )	Clancy C.J....Nguyen M.H.	2018
28	Saccharomyces cerevisiae-based probiotic as novel anti-fungal and anti-inflammatory agent for therapy of vaginal candidiasis. ( 29380641 )	Gabrielli E....Vecchiarelli A.	2018
29	The effect of a vaginal suppository formulation of dill (Anethum graveolens) in comparison to clotrimazole vaginal tablet on the treatment of vulvovaginal candidiasis. ( 29553834 )	Saghafi N....Bahman S.	2018
30	Usefulness of A9-D-glucan for diagnosis and follow-up of invasive candidiasis in onco-haematological patients. ( 29432826 )	Guitard J....Hennequin C.	2018
31	Chronic mucocutaneous candidiasis, a case study and literature review. ( 29500032 )	Khosravi A.R....Nikaein D.	2018
32	Tetraglochin cristatum (Britton) Roth: a medicinal plant from the Argentinean highlands with potential use in vaginal candidiasis. ( 29307753 )	Moreno M.A....Isla M.I.	2018
33	Nanolipid Gel of an Antimycotic Drug for Treating Vulvovaginal Candidiasis-Development and Evaluation. ( 29340981 )	Takalkar D....Desai N.	2018
34	Vulvovaginal candidiasis: species distribution of Candida and their antifungal susceptibility pattern. ( 29902998 )	Bitew A....Abebaw Y.	2018
35	Thymol, eugenol and lactobacilli in a medical device for the treatment of bacterial vaginosis and vulvovaginal candidiasis. ( 29874389 )	Murina F....Di Francesco S.	2018
36	Systemic hematogenous dissemination of mouse oral candidiasis is induced by oral mucositis. ( 29797142 )	Katagiri H....Tanaka A.	2018
37	Special Issue: <i>Candida</i> and Candidiasis. ( 29933544 )	Nett J.E.	2018
38	Utility of Ruxolitinib in a Child with Chronic Mucocutaneous Candidiasis Caused by a Novel STAT1 Gain-of-Function Mutation. ( 29934865 )	Bloomfield M....A edivA! A.	2018
39	IL-36 and IL-1/IL-17 Drive Immunity to Oral Candidiasis via Parallel Mechanisms. ( 29891557 )		2018
40	Promising alternative therapeutics for oral candidiasis. ( 29852856 )		2018
41	Amphotericin B-Loaded Plga Nanofibers: an Alternative Therapy Scheme for Local Treatment of Vulvovaginal Candidiasis. ( 29940181 )		2018
42	Patient Susceptibility to Candidiasis-A Potential for Adjunctive Immunotherapy. ( 29371502 )		2018
43	Antimicrobial photodynamic therapy as a new approach for the treatment of vulvovaginal candidiasis: preliminary results. ( 29931589 )		2018
44	Proanthocyanidin polymeric tannins from Stryphnodendron adstringens are effective against Candida spp. isolates and for vaginal candidiasis treatment. ( 29325916 )		2018
45	Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species. ( 29932786 )		2018
46	RISK FACTORS OF VULVOVAGINAL CANDIDIASIS IN DERMATO-VENEREOLOGY OUTPATIENTS CLINIC OF SOETOMO GENERAL HOSPITAL, SURABAYA, INDONESIA. ( 29619437 )		2018
47	Longitudinal trajectory of vulvovaginal candidiasis, trichomoniasis, and bacterial vaginosis during pregnancy as well as the impact on pregnancy outcomes: a preliminary study. ( 29685081 )		2018
48	Chair-Side Direct Microscopy Procedure for Diagnosis of Oral Candidiasis in an Adolescent. ( 29854484 )		2018
49	Prevalence and association of oral candidiasis with dysphagia in individuals with acquired brain injury. ( 29182379 )		2018
50	Amplitude-modulated cold atmospheric pressure plasma jet for treatment of oral candidiasis: In vivo study. ( 29949638 )		2018

Sources

Genes for Candidiasis

Genes related to Candidiasis (0 elite genes):

(show all 21)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	AIRE	Autoimmune Regulator	Protein Coding	65.88	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Disorders Publications Gene name Summaries (show sections)	15640689 12625412 11156688 (more) 14655274 16682278 9465297 18606876 19196253 16784312 12651856 10593569 19037923 16890195 16403019 16114041 15482854 9837820 16431348 12784192 17547716 18292755 12542742
2	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	44.71	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
3	IL17F	Interleukin 17F	Protein Coding	42.41	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
4	IL17RC	Interleukin 17 Receptor C	Protein Coding	41.58	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
5	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	41.28	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications Variants (show sections)
6	TRAF3IP2	TRAF3 Interacting Protein 2	Protein Coding	35.4	GeneCards inferred via : Disorders Publications Variants (show sections)
7	IL17RA	Interleukin 17 Receptor A	Protein Coding	35.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications Variants (show sections)
8	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	33.14	DISEASES inferred ¹⁵ GeneCards inferred via : Disorders Publications (show sections)
9	DEFB4A	Defensin Beta 4A	Protein Coding	29.84	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	20476598 11936455
10	HTN3	Histatin 3	Protein Coding	27.69	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	16940535 14659657
11	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	26.46	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	12821470 15040939 18299636 (more) 15963364 11566001
12	SKAP2	Src Kinase Associated Phosphoprotein 2	Protein Coding	24.3	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11476984 12182226 10733678 (more) 12437091
13	IL17A	Interleukin 17A	Protein Coding	23.88	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	PLB1	Phospholipase B1	Protein Coding	23.18	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵	12870130 11930319
15	IFNG	Interferon Gamma	Protein Coding	22.83	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	IL10	Interleukin 10	Protein Coding	22.72	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	APCS	Amyloid P Component, Serum	Protein Coding	19.33	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11556759 12437091 17472610
18	CANDF1	Candidiasis, Familial 1	Genetic Locus	16.13	GeneCards inferred via : Publications Gene name (show sections)
19	CANDN1	Candidiasis, Nail 1 (With ICAM1 Deficiency)	Genetic Locus	16.06	GeneCards inferred via : Publications Gene name (show sections)
20	CDR1	Cerebellar Degeneration Related Protein 1	Protein Coding	13.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	MBL2	Mannose Binding Lectin 2	Protein Coding	12.41	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Candidiasis

Sources

Expression for Candidiasis

Search GEO for disease gene expression data for Candidiasis.

Sources

Pathways for Candidiasis

Pathways related to Candidiasis according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	13.87	CARD9 CLEC7A DEFB4A HSP90AA1 HTN3 IFNG
2	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.12	HSP90AA1 IFNG IL10 IL17A IL17F IL17RA
3	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.71	HSP90AA1 IFNG IL10 IL17A STAT1
4	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.39	IFNG IL10 IL17A IL17F STAT1
5	NF-kappaB Signaling ⁴	12.35	CARD9 IFNG IL10 IL17A STAT1
6	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.34	HSP90AA1 IFNG IL10 IL17A IL17F STAT1
7	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.08	HSP90AA1 IFNG IL10 IL17A STAT1
8	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.06	CARD9 CLEC7A IL10 STAT1
9	Tuberculosis ³⁷	12.02	CARD9 CLEC7A IFNG IL10 STAT1
10	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	11.92	IFNG IL10 IL17A IL17RC STAT1
11	Th1 Differentiation Pathway ⁶⁵ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁵	11.77	IFNG IL10 IL17A IL17F STAT1
12	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.7	IFNG IL10 STAT1
13	Glucocorticoid receptor regulatory network ¹	11.66	HSP90AA1 IFNG STAT1
14	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.64	IFNG IL10 IL17A
15	Interleukin-4 and 13 signaling ⁶⁶	11.61	HSP90AA1 IL10 IL17A IL17F STAT1
16	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.59	IFNG IL10 IL17RA
17	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.56	IFNG IL10 IL17A
18	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	11.56	DEFB4A HSP90AA1 IFNG IL17A IL17F IL17RA
19	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.32	IL17A IL17F IL17RA IL17RC TRAF3IP2

Sources

GO Terms for Candidiasis

Cellular components related to Candidiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.28	APCS DEFB4A HSP90AA1 HTN3 IFNG IL10

Biological processes related to Candidiasis according to GeneCards Suite gene sharing:

(show all 15)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.91	AIRE DEFB4A IFNG IL10 IL17A
2	cytokine-mediated signaling pathway	GO:0019221	9.8	HSP90AA1 IL10 IL17A IL17F STAT1
3	humoral immune response	GO:0006959	9.67	AIRE IFNG TRAF3IP2
4	defense response to fungus	GO:0050832	9.56	HTN3 IL17A IL17RA IL17RC
5	defense response to protozoan	GO:0042832	9.55	CLEC7A IL10
6	chaperone-mediated protein complex assembly	GO:0051131	9.54	APCS HSP90AA1
7	regulation of interferon-gamma-mediated signaling pathway	GO:0060334	9.52	IFNG STAT1
8	positive regulation of interleukin-6 secretion	GO:2000778	9.5	IL17A IL17F IL17RC
9	granulocyte chemotaxis	GO:0071621	9.48	IL17RA IL17RC
10	fibroblast activation	GO:0072537	9.46	IL17A IL17RA
11	regulation of interleukin-6 biosynthetic process	GO:0045408	9.43	CARD9 IL17F
12	regulation of interleukin-2 biosynthetic process	GO:0045076	9.37	CARD9 IL17F
13	positive regulation of interleukin-23 production	GO:0032747	9.33	IFNG IL17A IL17RA
14	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.26	IL17A IL17F IL17RA IL17RC
15	interleukin-17-mediated signaling pathway	GO:0097400	8.92	IL17A IL17F IL17RA IL17RC

Molecular functions related to Candidiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.26	IFNG IL10 IL17A IL17F
2	interleukin-17 receptor activity	GO:0030368	8.62	IL17RA IL17RC

Sources

Sources for Candidiasis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia

Candidiasis

Aliases & Classifications for Candidiasis

MalaCards integrated aliases for Candidiasis:

Classifications:

External Ids:

Summaries for Candidiasis

Related Diseases for Candidiasis

Diseases in the Candidiasis family:

Diseases related to Candidiasis via text searches within MalaCards or GeneCards Suite gene sharing:

Comorbidity relations with Candidiasis via Phenotypic Disease Network (PDN): (show all 13)

Graphical network of the top 20 diseases related to Candidiasis:

Symptoms & Phenotypes for Candidiasis

MGI Mouse Phenotypes related to Candidiasis:

Drugs & Therapeutics for Candidiasis

Drugs for Candidiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: candidiasis

Genetic Tests for Candidiasis

Anatomical Context for Candidiasis

MalaCards organs/tissues related to Candidiasis:

Publications for Candidiasis

Articles related to Candidiasis:

Genes for Candidiasis

Genes related to Candidiasis (0 elite genes):

Variations for Candidiasis

Expression for Candidiasis

Pathways for Candidiasis

Pathways related to Candidiasis according to GeneCards Suite gene sharing:

GO Terms for Candidiasis

Cellular components related to Candidiasis according to GeneCards Suite gene sharing:

Biological processes related to Candidiasis according to GeneCards Suite gene sharing:

Molecular functions related to Candidiasis according to GeneCards Suite gene sharing:

Sources for Candidiasis

Inferred drug relations via UMLS ⁷³ / NDF-RT ⁵¹ :