MCID: CNM001
MIFTS: 18

Canomad Syndrome

Categories: Immune diseases, Muscle diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Canomad Syndrome

MalaCards integrated aliases for Canomad Syndrome:

Name: Canomad Syndrome 19 58 71
Chronic Ataxic Neuropathy-Ophthalmoplegia-Igm Paraprotein-Cold Agglutinins-Disialosyl Antibodies Syndrome 58
Chronic Ataxic Neuropathy Ophthalmoplegia M-Protein Agglutination Disialosyl Antibodies Syndrome 19
Chronic Sensory Ataxic Neuropathy with Anti-Disialosyl Igm Antibodies 58
Chronic Sensory Ataxic Neuropathy with Anti-Disialosyl Antibodies 19
Canda Syndrome 58

Characteristics:


Prevelance:

<1/1000000 (Worldwide) 58

Age Of Onset:

Adult,Elderly 58

Age Of Death:

normal life expectancy 58

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 C537980
ICD10 via Orphanet 32 G61.8
UMLS via Orphanet 72 C2931684
Orphanet 58 ORPHA71279
UMLS 71 C2931684

Summaries for Canomad Syndrome

GARD: 19 CANOMAD syndrome is a rare chronic immune-mediated demyelinating polyneuropathy. CANOMAD stands for Chronic Ataxic Neuropathy Ophthalmoplegia IgM paraprotein Cold Agglutinins Disialosyl antibodies. Signs and symptoms of CANOMAD may include loss of muscle, tendon, and joint sensation, abnormal gait (walk), ataxia, tingling sensation on the skin around the mouth or extremities, paralysis of eye muscles, difficulty swallowing and speaking, and rarely respiratory muscle weakness. This condition is caused by the presence of anti-diasialosyl antibodies in the body.

MalaCards based summary: Canomad Syndrome, also known as chronic ataxic neuropathy-ophthalmoplegia-igm paraprotein-cold agglutinins-disialosyl antibodies syndrome, is related to guillain-barre syndrome and miller fisher syndrome, and has symptoms including ataxia and ophthalmoplegia. Affiliated tissues include eye and skin.

Orphanet: 58 A rare chronic immune-mediated polyneuropathy characterized by a progressive disabling neuropathy with marked gait disturbance primarily due to sensory ataxia with concurrent cranial neuropathies (internal or external ophthalmoplegia, dysphagia, dysarthria, or facial weakness) and anti-disialosyl IgM antibodies.

Related Diseases for Canomad Syndrome

Diseases related to Canomad Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 guillain-barre syndrome 10.5
2 miller fisher syndrome 10.5
3 neuropathy 10.5
4 kearns-sayre syndrome 10.1
5 respiratory failure 10.0
6 polyneuropathy 10.0
7 monoclonal gammopathy of uncertain significance 10.0

Graphical network of the top 20 diseases related to Canomad Syndrome:



Diseases related to Canomad Syndrome

Symptoms & Phenotypes for Canomad Syndrome

UMLS symptoms related to Canomad Syndrome:


ataxia; ophthalmoplegia

Drugs & Therapeutics for Canomad Syndrome

Search Clinical Trials, NIH Clinical Center for Canomad Syndrome

Genetic Tests for Canomad Syndrome

Anatomical Context for Canomad Syndrome

Organs/tissues related to Canomad Syndrome:

MalaCards : Eye, Skin

Publications for Canomad Syndrome

Articles related to Canomad Syndrome:

# Title Authors PMID Year
1
The Spectrum of Ocular Manifestations in Patients with Waldenström's Macroglobulinemia. 62
34270382 2021
2
CANOMAD syndrome with respiratory failure. 62
32364342 2020
3
Monosialosyl Antibody in a Case Mimicking CANOMAD Syndrome. 62
31453857 2019
4
Corrigendum to "A case of false positive cardiac troponin I in CANOMAD syndrome" [Int. J. Cardiol. 222 (2016) 359-360]. 62
29499853 2018
5
A case of false positive cardiac troponin I in CANOMAD syndrome. 62
27500764 2016
6
Comparison of commercial tests for detecting multiple anti-ganglioside autoantibodies in patients with well-characterized immune-mediated peripheral neuropathies. 62
24409662 2013
7
[Identification and characterization of a monoclonal IgM reacting with disialylated gangliosides recognizing the CANOMAD syndrome]. 62
21896416 2011
8
The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. 62
11571215 2001

Variations for Canomad Syndrome

Expression for Canomad Syndrome

Search GEO for disease gene expression data for Canomad Syndrome.

Pathways for Canomad Syndrome

GO Terms for Canomad Syndrome

Sources for Canomad Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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