MCID: CNM001
MIFTS: 17

Canomad Syndrome

Categories: Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Canomad Syndrome

MalaCards integrated aliases for Canomad Syndrome:

Name: Canomad Syndrome 52 58 71
Chronic Ataxic Neuropathy-Ophthalmoplegia-Igm Paraprotein-Cold Agglutinins-Disialosyl Antibodies Syndrome 58
Chronic Ataxic Neuropathy Ophthalmoplegia M-Protein Agglutination Disialosyl Antibodies Syndrome 52
Chronic Sensory Ataxic Neuropathy with Anti-Disialosyl Igm Antibodies 58
Chronic Sensory Ataxic Neuropathy with Anti-Disialosyl Antibodies 52
Canda Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
canomad syndrome
Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

MESH via Orphanet 44 C537980
ICD10 via Orphanet 33 G61.8
UMLS via Orphanet 72 C2931684
Orphanet 58 ORPHA71279
UMLS 71 C2931684

Summaries for Canomad Syndrome

NIH Rare Diseases : 52 CANOMAD syndrome is a rare chronic immune-mediated demyelinating polyneuropathy. CANOMAD stands for Chronic Ataxic Neuropathy Ophthalmoplegia IgM paraprotein Cold Agglutinins Disialosyl antibodies . Signs and symptoms of CANOMAD may include loss of muscle, tendon, and joint sensation, abnormal gait (walk), ataxia , tingling sensation on the skin around the mouth or extremities, paralysis of eye muscles, difficulty swallowing and speaking, and rarely respiratory muscle weakness. This condition is caused by the presence of anti-diasialosyl antibodies in the body. Oral or intravenous corticosteroids , ?-interferons, plasma exchange, intravenous immunoglobulin (IVIG), and cytotoxic drugs have all been used in treating CANOMAD with varying success.

MalaCards based summary : Canomad Syndrome, also known as chronic ataxic neuropathy-ophthalmoplegia-igm paraprotein-cold agglutinins-disialosyl antibodies syndrome, is related to ataxia and polyneuropathy, adult-onset and miller fisher syndrome, and has symptoms including ataxia and ophthalmoplegia. Affiliated tissues include eye, skin and testes.

Related Diseases for Canomad Syndrome

Diseases related to Canomad Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 ataxia and polyneuropathy, adult-onset 10.5
2 miller fisher syndrome 10.5
3 neuropathy 10.5
4 kearns-sayre syndrome 10.1

Symptoms & Phenotypes for Canomad Syndrome

UMLS symptoms related to Canomad Syndrome:


ataxia, ophthalmoplegia

Drugs & Therapeutics for Canomad Syndrome

Search Clinical Trials , NIH Clinical Center for Canomad Syndrome

Genetic Tests for Canomad Syndrome

Anatomical Context for Canomad Syndrome

MalaCards organs/tissues related to Canomad Syndrome:

40
Eye, Skin, Testes

Publications for Canomad Syndrome

Articles related to Canomad Syndrome:

# Title Authors PMID Year
1
Relapsing sensorimotor neuropathy with ophthalmoplegia, antidisialosyl antibodies, and extramembranous glomerulonephritis. 52
16258949 2006
2
Monosialosyl Antibody in a Case Mimicking CANOMAD Syndrome. 61
31453857 2019
3
Corrigendum to "A case of false positive cardiac troponin I in CANOMAD syndrome" [Int. J. Cardiol. 222 (2016) 359-360]. 61
29499853 2018
4
A case of false positive cardiac troponin I in CANOMAD syndrome. 61
27500764 2016
5
Comparison of commercial tests for detecting multiple anti-ganglioside autoantibodies in patients with well-characterized immune-mediated peripheral neuropathies. 61
24409662 2013
6
[Identification and characterization of a monoclonal IgM reacting with disialylated gangliosides recognizing the CANOMAD syndrome]. 61
21896416 2011
7
The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. 61
11571215 2001

Variations for Canomad Syndrome

Expression for Canomad Syndrome

Search GEO for disease gene expression data for Canomad Syndrome.

Pathways for Canomad Syndrome

GO Terms for Canomad Syndrome

Sources for Canomad Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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