MCID: CPL005
MIFTS: 37

Capillary Disease

Categories: Cardiovascular diseases

Aliases & Classifications for Capillary Disease

MalaCards integrated aliases for Capillary Disease:

Name: Capillary Disease 12 15
Disease of Capillaries 12 70

Classifications:



External Ids:

Disease Ontology 12 DOID:1271
ICD9CM 34 448
SNOMED-CT 67 58729003
ICD10 32 I78 I78.9
UMLS 70 C0155765

Summaries for Capillary Disease

Disease Ontology : 12 A vascular disease that is located in the capillaries.

MalaCards based summary : Capillary Disease, also known as disease of capillaries, is related to blood protein disease and capillary malformations, congenital, and has symptoms including petechiae of skin An important gene associated with Capillary Disease is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and Akt Signaling. Affiliated tissues include capillaries, skin and breast, and related phenotypes are cellular and cardiovascular system

Related Diseases for Capillary Disease

Diseases related to Capillary Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 blood protein disease 30.0 VEGFA ICOSLG CD34 ALB
2 capillary malformations, congenital 10.9
3 skin epithelioid hemangioma 10.5 PECAM1 CD34
4 aortic malignant tumor 10.5 PECAM1 CD34
5 central nervous system angiosarcoma 10.5 PECAM1 CD34
6 intravascular angioleiomyoma 10.5 PECAM1 CD34
7 heart fibrosarcoma 10.5 PECAM1 CD34
8 ovarian angiosarcoma 10.5 PECAM1 CD34
9 riedel's fibrosing thyroiditis 10.5 CD34 ALB
10 pacinian tumor 10.5 SLC2A1 CD34
11 conventional angiosarcoma 10.4 PECAM1 CD34
12 gallbladder leiomyosarcoma 10.4 PECAM1 CD34
13 thyroid sarcoma 10.4 PECAM1 CD34
14 angiomyoma 10.4 PECAM1 CD34
15 gallbladder melanoma 10.4 SLC2A1 PECAM1 IL2
16 septate uterus 10.4 KDR FLT1
17 glomangiosarcoma 10.4 PECAM1 CD34
18 breast hemangioma 10.4 PECAM1 CD34
19 hemangioma of spleen 10.4 PECAM1 CD34
20 liposarcoma of bone 10.4 PECAM1 CD34
21 prostate angiosarcoma 10.4 VEGFA PECAM1 CD34
22 colonic lymphangioma 10.4 PECAM1 CD34
23 perivascular tumor 10.4 SLC2A1 PECAM1 CD34
24 central nervous system hemangioma 10.4 VEGFA PECAM1 CD34
25 pediatric angiosarcoma 10.4 VEGFA PECAM1 CD34
26 retroperitoneal hemangiopericytoma 10.4 VEGFA PECAM1 CD34
27 microcystic meningioma 10.4 VEGFA FLT1
28 bacillary angiomatosis 10.4 VEGFA PECAM1 CD34
29 angiokeratoma of mibelli 10.4 KDR FLT1
30 liver leiomyoma 10.4 PECAM1 CD34
31 hobnail hemangioma 10.4 PECAM1 CD34
32 bartonellosis 10.4 VEGFA PECAM1 CD34
33 erythema elevatum diutinum 10.4 PECAM1 CD34
34 malignant ciliary body melanoma 10.4 KDR FLT1
35 pulmonary vein stenosis 10.4 PECAM1 KDR
36 breast angiosarcoma 10.4 PECAM1 KDR CD34
37 kaposiform hemangioendothelioma 10.4 PECAM1 KDR CD34
38 anca-associated vasculitis 10.4 IL2 ANGPT2
39 angiomatous meningioma 10.4 VEGFA CD34
40 sarcomatoid squamous cell skin carcinoma 10.4 PECAM1 CD34
41 juvenile nasopharyngeal angiofibroma 10.4 VEGFA PECAM1 FGF2
42 pericardium disease 10.4 VEGFA CD34 ALB
43 plague 10.4 PECAM1 IL2 ALB
44 chickenpox 10.4 IL2 ICOSLG ALB
45 heart sarcoma 10.4 PECAM1 CD34
46 thymus gland disease 10.4 IL2 ICOSLG CD34
47 coccidiosis 10.4 IL2 ICOSLG ALB
48 mucosal melanoma 10.4 VEGFA KDR IL2
49 hypertensive encephalopathy 10.4 VEGFA FLT1 ALB
50 skin sarcoma 10.4 PECAM1 CD34

Graphical network of the top 20 diseases related to Capillary Disease:



Diseases related to Capillary Disease

Symptoms & Phenotypes for Capillary Disease

UMLS symptoms related to Capillary Disease:


petechiae of skin

MGI Mouse Phenotypes related to Capillary Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 ADRB2 ALB ANGPT2 ANTXR1 CD22 CD34
2 cardiovascular system MP:0005385 10.28 ADRB2 ALB ANGPT2 ANTXR1 CSF2 FGF2
3 hematopoietic system MP:0005397 10.21 ADRB2 ANGPT2 CD22 CD34 CSF2 FGF2
4 homeostasis/metabolism MP:0005376 10.17 ADRB2 ALB ANGPT2 CD34 CSF2 FGF2
5 immune system MP:0005387 10.1 ADRB2 ALB ANGPT2 ANTXR1 CD22 CD34
6 mortality/aging MP:0010768 10 ALB ANGPT2 ANTXR1 CD22 CSF2 FGF2
7 muscle MP:0005369 9.65 ADRB2 ALB FGF2 FLT1 KDR PECAM1
8 neoplasm MP:0002006 9.23 ALB ANTXR1 CD34 CSF2 FGF2 IL2

Drugs & Therapeutics for Capillary Disease

Search Clinical Trials , NIH Clinical Center for Capillary Disease

Genetic Tests for Capillary Disease

Anatomical Context for Capillary Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Capillary Disease:

19
Capillaries

MalaCards organs/tissues related to Capillary Disease:

40
Skin, Breast, Bone, Heart, Eye, Brain, Thyroid

Publications for Capillary Disease

Articles related to Capillary Disease:

(show all 15)
# Title Authors PMID Year
1
Incidence and risk factors of vascular complications in people with impaired fasting glucose: a national cohort study in Korea. 61
33177611 2020
2
Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension. 61
30880577 2019
3
Hemodynamic heterogeneity of connective tissue disease patients with borderline mean pulmonary artery pressure and its distinctive characters from those with normal pulmonary artery pressure: a retrospective study. 61
29777409 2018
4
["Lace-like" occlusive retinal vasculitis with capillary disease on ultra-wide field imaging]. 61
29910130 2018
5
Central and peripheral pulmonary vascular resistance: Implications for who should undergo pulmonary thromboendarterectomy. 61
25997984 2015
6
Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis--Evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis. 61
25363217 2014
7
Imaging in pulmonary hypertension. 61
21163459 2010
8
Endoneurial capillary abnormalities in mild human diabetic neuropathy. 61
1640230 1992
9
Half-life of cotton-wool spots in the acquired immunodeficiency syndrome. 61
2092789 1990
10
Effects of pancreatic islet implantation on the morphology of retinal capillaries in alloxan diabetic mice. 61
6407274 1983
11
[Peripheral retinal ischemic capillary disease and indications for photocoagulation]. 61
527204 1979
12
The role of capillary wall in the histogenesis of glomerular diseases. 61
129690 1975
13
Growth hormone, sorbitol, and diabetic capillary disease. 61
4102056 1971
14
Growth hormone, sorbitol, and diabetic capillary disease. 61
4100908 1971
15
[Two blood protein disorders associated with diabetic capillary disease]. 61
14901773 1951

Variations for Capillary Disease

Expression for Capillary Disease

Search GEO for disease gene expression data for Capillary Disease.

Pathways for Capillary Disease

Pathways related to Capillary Disease according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 TEK RYR3 RYR1 KDR IL2 FLT1
2
Show member pathways
13.35 TEK KDR IL2 FLT1 FGF2 CSF2
3
Show member pathways
13.25 VEGFA TEK SERPING1 PECAM1 IL2 CSF2
4
Show member pathways
13.24 TEK RYR3 RYR1 KDR IL2 FLT1
5
Show member pathways
13.23 TEK SLC2A1 KDR IL2 FLT1 FGF2
6
Show member pathways
12.87 VEGFA TEK KDR IL2 FLT1 FGF2
7 12.68 VEGFA TEK KDR FLT1 FGF2 ANGPT2
8
Show member pathways
12.63 VEGFA TEK KDR FLT1 FGF2 ANGPT2
9
Show member pathways
12.33 VEGFA KDR FLT1 FGF2
10
Show member pathways
12.33 TEK KDR IL2 FLT1 FGF2
11
Show member pathways
12.27 VEGFA KDR FLT1 FGF2
12 12.08 VEGFA RYR3 RYR1 KDR FLT1 FGF2
13 12.07 PECAM1 ICOSLG CD34 CD22
14 12.01 VEGFA KDR FGF2 ALB
15 12 TEK KDR FLT1 FGF2 ANGPT2
16 11.94 IL2 CSF2 CD34 CD22
17
Show member pathways
11.79 VEGFA KDR FLT1
18 11.79 VEGFA TEK FLT1 CSF2
19 11.76 VEGFA TEK SLC2A1 FLT1 ANGPT2
20 11.72 VEGFA SLC2A1 FGF2
21 11.67 IL2 CSF2 CD34
22
Show member pathways
11.59 VEGFA IL2 CSF2
23 11.44 VEGFA KDR FGF2
24 11.4 VEGFA SERPING1 KDR FGF2
25 11.38 TEK PECAM1 KDR FLT1 FGF2 ANGPT2
26 11.34 VEGFA SLC2A1 ANGPT2
27 11.3 VEGFA KDR FLT1 FGF2
28 11.14 VEGFA FLT1 FGF2
29 11.09 VEGFA SLC2A1 KDR FLT1
30 10.9 TEK KDR IL2 FLT1 FGF2 CSF2
31
Show member pathways
10.86 VEGFA KDR FLT1
32 10.76 RYR3 RYR1
33 10.4 VEGFA TEK KDR FLT1 FGF2

GO Terms for Capillary Disease

Cellular components related to Capillary Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.07 TEK SLC2A1 RYR3 RYR1 PECAM1 KDR
2 extracellular space GO:0005615 9.81 VEGFA SERPING1 PECAM1 IL2 FLT1 FGF2
3 membrane raft GO:0045121 9.71 TEK SLC2A1 PECAM1 KDR
4 extracellular region GO:0005576 9.7 VEGFA TEK SERPING1 KDR IL2 FLT1
5 receptor complex GO:0043235 9.67 TEK KDR FLT1 ADRB2
6 platelet alpha granule lumen GO:0031093 9.5 VEGFA SERPING1 ALB
7 integral component of plasma membrane GO:0005887 9.28 TEK SLC2A1 RYR1 PECAM1 KDR FLT1

Biological processes related to Capillary Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.19 VEGFA TEK RYR1 KDR FLT1 FGF2
2 negative regulation of apoptotic process GO:0043066 10.08 VEGFA TEK KDR IL2 ALB
3 positive regulation of cell proliferation GO:0008284 10.04 VEGFA KDR IL2 FLT1 FGF2 CSF2
4 positive regulation of cell migration GO:0030335 9.97 VEGFA PECAM1 KDR FLT1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 VEGFA TEK KDR FGF2
6 leukocyte migration GO:0050900 9.95 TEK PECAM1 CD34 ANGPT2
7 platelet degranulation GO:0002576 9.85 VEGFA SERPING1 PECAM1 ALB
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 VEGFA IL2 CSF2
9 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 VEGFA KDR FLT1
10 positive regulation of MAP kinase activity GO:0043406 9.81 VEGFA FLT1 FGF2
11 positive regulation of blood vessel endothelial cell migration GO:0043536 9.81 VEGFA KDR FGF2
12 positive regulation of kinase activity GO:0033674 9.8 TEK KDR IL2 FLT1
13 response to hypoxia GO:0001666 9.8 VEGFA TEK SLC2A1 RYR1 ANGPT2
14 angiogenesis GO:0001525 9.8 VEGFA TEK KDR FLT1 FGF2 ANGPT2
15 release of sequestered calcium ion into cytosol GO:0051209 9.77 RYR3 RYR1 FGF2
16 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.76 VEGFA KDR FGF2
17 positive regulation of endothelial cell proliferation GO:0001938 9.76 VEGFA TEK KDR FGF2
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.75 VEGFA KDR FLT1
19 positive regulation of endothelial cell migration GO:0010595 9.73 VEGFA TEK KDR FGF2
20 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.71 TEK FLT1 FGF2
21 positive regulation of focal adhesion assembly GO:0051894 9.7 VEGFA TEK KDR
22 cell migration involved in sprouting angiogenesis GO:0002042 9.69 VEGFA KDR FGF2
23 positive regulation of phospholipase C activity GO:0010863 9.68 FLT1 FGF2
24 positive regulation of vasculogenesis GO:2001214 9.68 KDR CD34
25 positive regulation of positive chemotaxis GO:0050927 9.68 VEGFA KDR
26 cellular response to caffeine GO:0071313 9.67 RYR3 RYR1
27 stem cell proliferation GO:0072089 9.66 FGF2 CD34
28 vascular endothelial growth factor signaling pathway GO:0038084 9.65 VEGFA KDR FLT1
29 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 VEGFA TEK KDR FLT1 FGF2
30 paracrine signaling GO:0038001 9.64 FGF2 CD34
31 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.63 VEGFA KDR
32 positive regulation of protein phosphorylation GO:0001934 9.63 VEGFA TEK PECAM1 KDR IL2 FGF2
33 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.62 VEGFA KDR
34 endothelium development GO:0003158 9.62 KDR CD34
35 positive regulation of epithelial tube formation GO:1905278 9.61 VEGFA FGF2
36 glomerulus vasculature development GO:0072012 9.61 TEK ANGPT2
37 Tie signaling pathway GO:0048014 9.6 TEK ANGPT2
38 glomerular endothelium development GO:0072011 9.56 PECAM1 CD34
39 vascular wound healing GO:0061042 9.54 VEGFA KDR CD34
40 positive regulation of MAPK cascade GO:0043410 9.43 VEGFA TEK KDR FLT1 FGF2 ADRB2
41 positive regulation of angiogenesis GO:0045766 9.17 VEGFA TEK KDR FLT1 FGF2 CD34

Molecular functions related to Capillary Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 10.03 VEGFA TEK SLC2A1 KDR ICOSLG FGF2
2 cytokine activity GO:0005125 9.78 VEGFA IL2 FGF2 CSF2
3 growth factor activity GO:0008083 9.62 VEGFA IL2 FGF2 CSF2
4 protein binding GO:0005515 9.62 VEGFA TPX2 TEK SLC2A1 SERPING1 RYR3
5 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.54 TEK KDR FLT1
6 calcium-release channel activity GO:0015278 9.46 RYR3 RYR1
7 growth factor binding GO:0019838 9.43 TEK KDR FLT1
8 vascular endothelial growth factor-activated receptor activity GO:0005021 9.4 KDR FLT1
9 calcium-induced calcium release activity GO:0048763 9.16 RYR3 RYR1
10 ryanodine-sensitive calcium-release channel activity GO:0005219 8.96 RYR3 RYR1

Sources for Capillary Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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