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MCID: CPL005
MIFTS: 36

Capillary Disease

Categories: Cardiovascular diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Capillary Disease

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MalaCards integrated aliases for Capillary Disease:

Name: Capillary Disease 12 15
Disease of Capillaries 12 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1271
ICD9CM 34 448
SNOMED-CT 67 58729003
ICD10 32 I78 I78.9
UMLS 71 C0155765
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Summaries for Capillary Disease

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Disease Ontology : 12 A vascular disease that is located in the capillaries.

MalaCards based summary : Capillary Disease, also known as disease of capillaries, is related to capillary leak syndrome and blood protein disease, and has symptoms including petechiae of skin An important gene associated with Capillary Disease is SLC2A1 (Solute Carrier Family 2 Member 1), and among its related pathways/superpathways are Akt Signaling and CREB Pathway. Affiliated tissues include capillaries, skin and lung, and related phenotypes are cellular and cardiovascular system

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Related Diseases for Capillary Disease

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Diseases related to Capillary Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 capillary leak syndrome 30.1 TPX2 SERPING1 IL2 ICOSLG CSF2 CD22
2 blood protein disease 30.0 VEGFA ICOSLG CD34 ALB
3 capillary malformations, congenital 11.0
4 skin epithelioid hemangioma 10.7 PECAM1 CD34
5 aortic malignant tumor 10.6 PECAM1 CD34
6 central nervous system angiosarcoma 10.6 PECAM1 CD34
7 intravascular angioleiomyoma 10.6 PECAM1 CD34
8 heart fibrosarcoma 10.6 PECAM1 CD34
9 ovarian angiosarcoma 10.6 PECAM1 CD34
10 conventional angiosarcoma 10.6 PECAM1 CD34
11 angiomyoma 10.6 PECAM1 CD34
12 gallbladder melanoma 10.6 SLC2A1 PECAM1 IL2
13 septate uterus 10.6 KDR FLT1
14 prostate angiosarcoma 10.6 VEGFA PECAM1 CD34
15 gallbladder leiomyosarcoma 10.6 PECAM1 CD34
16 glomangiosarcoma 10.6 PECAM1 CD34
17 central nervous system hemangioma 10.6 VEGFA PECAM1 CD34
18 pacinian tumor 10.6 SLC2A1 CD34
19 pediatric angiosarcoma 10.6 VEGFA PECAM1 CD34
20 thyroid sarcoma 10.6 PECAM1 CD34
21 retroperitoneal hemangiopericytoma 10.6 VEGFA PECAM1 CD34
22 bacillary angiomatosis 10.6 VEGFA PECAM1 CD34
23 lymphangiosarcoma 10.6 VEGFA PECAM1 CD34
24 liposarcoma of bone 10.6 PECAM1 CD34
25 hemangioma of spleen 10.6 PECAM1 CD34
26 angiokeratoma of mibelli 10.6 KDR FLT1
27 liver leiomyoma 10.5 PECAM1 CD34
28 kaposiform hemangioendothelioma 10.5 PECAM1 KDR CD34
29 colonic lymphangioma 10.5 PECAM1 CD34
30 microcystic meningioma 10.5 VEGFA FLT1
31 mast cell neoplasm 10.5 IL2 ICOSLG CD34
32 hemorrhagic cystitis 10.5 IL2 CD34 ALB
33 pulmonary vein stenosis 10.5 PECAM1 KDR
34 juvenile nasopharyngeal angiofibroma 10.5 VEGFA PECAM1 FGF2
35 poems syndrome 10.5 VEGFA IL2 FGF2
36 mucosal melanoma 10.5 VEGFA KDR IL2
37 autoimmune disease of blood 10.5 IL2 ICOSLG ALB
38 hydrops, lactic acidosis, and sideroblastic anemia 10.5 VEGFA SERPING1 ALB
39 familial glomangioma 10.5 TEK FGF2
40 sarcomatoid squamous cell skin carcinoma 10.5 PECAM1 CD34
41 coccidiosis 10.5 IL2 ICOSLG ALB
42 conjunctival disease 10.5 IL2 ICOSLG ALB
43 hepatic vascular disease 10.5 VEGFA CD34 ALB
44 hobnail hemangioma 10.5 PECAM1 CD34
45 hypertensive encephalopathy 10.5 VEGFA FLT1 ALB
46 epithelioid hemangioendothelioma 10.5 VEGFA KDR FLT1
47 rectal disease 10.5 IL2 ICOSLG ALB
48 breast hemangioma 10.5 PECAM1 CD34
49 spinal cord disease 10.5 IL2 ICOSLG ALB
50 lung non-squamous non-small cell carcinoma 10.5 VEGFA KDR FLT1

Graphical network of the top 20 diseases related to Capillary Disease:



Diseases related to Capillary Disease
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Symptoms & Phenotypes for Capillary Disease

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UMLS symptoms related to Capillary Disease:


petechiae of skin

MGI Mouse Phenotypes related to Capillary Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 ALB ANGPT2 ANTXR1 CD22 CD34 CSF2
2 cardiovascular system MP:0005385 10.25 ALB ANGPT2 ANTXR1 CSF2 FGF2 FLT1
3 hematopoietic system MP:0005397 10.15 CD22 CD34 CSF2 FGF2 FLT1 IL2
4 homeostasis/metabolism MP:0005376 10.13 ALB ANGPT2 CD34 CSF2 FGF2 FLT1
5 immune system MP:0005387 10.07 ALB ANGPT2 ANTXR1 CD22 CD34 CSF2
6 mortality/aging MP:0010768 10 ALB ANGPT2 ANTXR1 CD22 CSF2 FGF2
7 muscle MP:0005369 9.61 ALB FGF2 FLT1 KDR PECAM1 RYR1
8 neoplasm MP:0002006 9.23 ALB ANTXR1 CD34 CSF2 FGF2 IL2
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Drugs & Therapeutics for Capillary Disease

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Search Clinical Trials , NIH Clinical Center for Capillary Disease

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Genetic Tests for Capillary Disease

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Anatomical Context for Capillary Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Capillary Disease:

19
Capillaries

MalaCards organs/tissues related to Capillary Disease:

40
Skin, Lung, Endothelial, Pancreatic Islet
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Publications for Capillary Disease

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Articles related to Capillary Disease:

(show all 14)
# Title Authors PMID Year
1
Right ventricular outflow tract velocity time integral-to-pulmonary artery systolic pressure ratio: a non-invasive metric of pulmonary arterial compliance differs across the spectrum of pulmonary hypertension. 61
30880577 2019
2
Hemodynamic heterogeneity of connective tissue disease patients with borderline mean pulmonary artery pressure and its distinctive characters from those with normal pulmonary artery pressure: a retrospective study. 61
29777409 2018
3
["Lace-like" occlusive retinal vasculitis with capillary disease on ultra-wide field imaging]. 61
29910130 2018
4
Central and peripheral pulmonary vascular resistance: Implications for who should undergo pulmonary thromboendarterectomy. 61
25997984 2015
5
Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis--Evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis. 61
25363217 2014
6
Imaging in pulmonary hypertension. 61
21163459 2010
7
Endoneurial capillary abnormalities in mild human diabetic neuropathy. 61
1640230 1992
8
Half-life of cotton-wool spots in the acquired immunodeficiency syndrome. 61
2092789 1990
9
Effects of pancreatic islet implantation on the morphology of retinal capillaries in alloxan diabetic mice. 61
6407274 1983
10
[Peripheral retinal ischemic capillary disease and indications for photocoagulation]. 61
527204 1979
11
The role of capillary wall in the histogenesis of glomerular diseases. 61
129690 1975
12
Growth hormone, sorbitol, and diabetic capillary disease. 61
4102056 1971
13
Growth hormone, sorbitol, and diabetic capillary disease. 61
4100908 1971
14
[Two blood protein disorders associated with diabetic capillary disease]. 61
14901773 1951
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Variations for Capillary Disease

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Expression for Capillary Disease

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Search GEO for disease gene expression data for Capillary Disease.
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Pathways for Capillary Disease

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Pathways related to Capillary Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Akt Signaling 63
Show member pathways
 13.34 TEK KDR IL2 FLT1 FGF2 CSF2
2
CREB Pathway 63
Show member pathways
 13.24 TEK RYR3 RYR1 KDR IL2 FLT1
3
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.24 VEGFA TEK SERPING1 PECAM1 IL2 CSF2
4
PAK Pathway 63
Show member pathways
 13.22 TEK SLC2A1 KDR IL2 FLT1 FGF2
5
PI3K-Akt signaling pathway 36
Show member pathways
 12.86 VEGFA TEK KDR IL2 FLT1 FGF2
6
MAPK signaling pathway 36 1
12.67 VEGFA TEK KDR FLT1 FGF2 ANGPT2
7
Ras signaling pathway 36
Show member pathways
 12.62 VEGFA TEK KDR FLT1 FGF2 ANGPT2
8
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.32 TEK KDR IL2 FLT1 FGF2
9
RhoGDI Pathway 63
Show member pathways
 12.31 VEGFA KDR FLT1 FGF2
10
Cell adhesion molecules (CAMs) 36
12.06 PECAM1 ICOSLG CD34 CD22
11
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
12 VEGFA KDR FGF2 ALB
12
Tyrosine Kinases / Adaptors 4
11.97 TEK KDR FLT1 FGF2 ANGPT2
13
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.93 IL2 CSF2 CD34 CD22
14
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.78 VEGFA KDR FLT1
15
Rheumatoid arthritis 36
11.78 VEGFA TEK FLT1 CSF2
16
Neural Stem Cells and Lineage-specific Markers 64
11.7 VEGFA SLC2A1 FGF2
17
HIF-1 signaling pathway 36
11.69 VEGFA TEK SLC2A1 FLT1 ANGPT2
18
Dendritic Cells Developmental Lineage Pathway 64
11.66 IL2 CSF2 CD34
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.58 VEGFA IL2 CSF2
20
Integrins in angiogenesis 1
11.44 VEGFA KDR FGF2
21
Angiogenesis (CST) 4
11.38 TEK PECAM1 KDR FLT1 FGF2 ANGPT2
22
Cell adhesion_Plasmin signaling 22
11.36 VEGFA SERPING1 KDR FGF2
23
Photodynamic therapy-induced HIF-1 survival signaling 1
11.33 VEGFA SLC2A1 ANGPT2
24
Vemurafenib Pathway, Pharmacodynamics 60
11.26 VEGFA KDR FLT1 FGF2
25
Glypican 1 network 1
11.13 VEGFA FLT1 FGF2
26
HIF-2-alpha transcription factor network 1
10.99 VEGFA SLC2A1 KDR FLT1
27
G-protein signaling_Rap2B regulation pathway 22
10.88 TEK KDR IL2 FLT1 FGF2 CSF2
28
VEGF binds to VEGFR leading to receptor dimerization 65
Show member pathways
 10.84 VEGFA KDR FLT1
29
Cell-type Dependent Selectivity of CCK2R Signaling 1
10.75 RYR3 RYR1
30
Angiogenesis (WikiPathways) 1
10.4 VEGFA TEK KDR FLT1 FGF2
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GO Terms for Capillary Disease

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Cellular components related to Capillary Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.76 TEK SLC2A1 RYR1 PECAM1 KDR FLT1
2 membrane raft GO:0045121 9.67 TEK SLC2A1 PECAM1 KDR
3 external side of plasma membrane GO:0009897 9.65 PECAM1 ICOSLG CD34 CD22 ANTXR1
4 extracellular space GO:0005615 9.61 VEGFA SERPING1 PECAM1 IL2 FLT1 FGF2
5 platelet alpha granule lumen GO:0031093 9.5 VEGFA SERPING1 ALB
6 extracellular region GO:0005576 9.36 VEGFA TEK SERPING1 KDR IL2 FLT1

Biological processes related to Capillary Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.2 VEGFA TEK RYR1 KDR FLT1 FGF2
2 negative regulation of apoptotic process GO:0043066 10.08 VEGFA TEK KDR IL2 ALB
3 positive regulation of cell proliferation GO:0008284 10.05 VEGFA KDR IL2 FLT1 FGF2 CSF2
4 MAPK cascade GO:0000165 9.99 TEK IL2 FGF2 CSF2
5 positive regulation of cell migration GO:0030335 9.97 VEGFA PECAM1 KDR FLT1
6 leukocyte migration GO:0050900 9.94 TEK PECAM1 CD34 ANGPT2
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.85 TEK KDR FLT1
8 platelet degranulation GO:0002576 9.85 VEGFA SERPING1 PECAM1 ALB
9 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFA TEK PECAM1 KDR IL2
10 positive regulation of MAPK cascade GO:0043410 9.84 TEK KDR FLT1 FGF2
11 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 VEGFA KDR FLT1
12 positive regulation of MAP kinase activity GO:0043406 9.82 VEGFA FLT1 FGF2
13 positive regulation of endothelial cell migration GO:0010595 9.81 VEGFA TEK KDR
14 release of sequestered calcium ion into cytosol GO:0051209 9.8 RYR3 RYR1 FGF2
15 positive regulation of blood vessel endothelial cell migration GO:0043536 9.79 VEGFA KDR FGF2
16 positive regulation of kinase activity GO:0033674 9.78 TEK KDR IL2 FLT1
17 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.76 VEGFA KDR FGF2
18 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 VEGFA KDR FLT1
19 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 VEGFA PECAM1 IL2 CSF2
20 response to hypoxia GO:0001666 9.72 VEGFA TEK SLC2A1 RYR1 ANGPT2
21 positive regulation of endothelial cell proliferation GO:0001938 9.71 VEGFA TEK KDR FGF2
22 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.7 TEK FLT1 FGF2
23 positive regulation of focal adhesion assembly GO:0051894 9.69 VEGFA TEK KDR
24 positive regulation of phospholipase C activity GO:0010863 9.68 FLT1 FGF2
25 positive regulation of vasculogenesis GO:2001214 9.67 KDR CD34
26 positive regulation of positive chemotaxis GO:0050927 9.67 VEGFA KDR
27 cell migration involved in sprouting angiogenesis GO:0002042 9.67 VEGFA KDR FGF2
28 cellular response to caffeine GO:0071313 9.66 RYR3 RYR1
29 stem cell proliferation GO:0072089 9.66 FGF2 CD34
30 paracrine signaling GO:0038001 9.64 FGF2 CD34
31 endothelium development GO:0003158 9.63 KDR CD34
32 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.61 VEGFA KDR
33 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.61 VEGFA KDR
34 glomerulus vasculature development GO:0072012 9.6 TEK ANGPT2
35 Tie signaling pathway GO:0048014 9.59 TEK ANGPT2
36 glomerular endothelium development GO:0072011 9.57 PECAM1 CD34
37 vascular endothelial growth factor signaling pathway GO:0038084 9.54 VEGFA KDR FLT1
38 angiogenesis GO:0001525 9.5 VEGFA TEK PECAM1 KDR FLT1 FGF2
39 sprouting angiogenesis GO:0002040 9.46 VEGFA TEK KDR FLT1
40 vascular wound healing GO:0061042 9.43 VEGFA KDR CD34
41 positive regulation of angiogenesis GO:0045766 9.17 VEGFA TEK KDR FLT1 FGF2 CD34

Molecular functions related to Capillary Disease according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.39 VEGFA TPX2 TEK SLC2A1 SERPING1 RYR3
2 identical protein binding GO:0042802 10.04 VEGFA TEK SLC2A1 KDR ICOSLG FGF2
3 cytokine activity GO:0005125 9.78 VEGFA IL2 FGF2 CSF2
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.5 TEK KDR FLT1
5 calcium-release channel activity GO:0015278 9.46 RYR3 RYR1
6 growth factor activity GO:0008083 9.46 VEGFA IL2 FGF2 CSF2
7 growth factor binding GO:0019838 9.43 TEK KDR FLT1
8 vascular endothelial growth factor binding GO:0038085 9.4 KDR FLT1
9 vascular endothelial growth factor-activated receptor activity GO:0005021 9.37 KDR FLT1
10 calcium-induced calcium release activity GO:0048763 8.96 RYR3 RYR1
11 ryanodine-sensitive calcium-release channel activity GO:0005219 8.62 RYR3 RYR1
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Sources for Capillary Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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