MCID: CPL006
MIFTS: 53

Capillary Hemangioma

Categories: Cardiovascular diseases, Cancer diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Capillary Hemangioma

MalaCards integrated aliases for Capillary Hemangioma:

Name: Capillary Hemangioma 12 15
Strawberry Nevus of Skin 12 73
Infantile Hemangioma 12 37
Cellular Hemangioma of Infancy 12
Congenital Vascular Hamartoma 12
Congenital Vascular Naevus 12
Strawberry Haemangioma 12
Hemangioma, Cavernous 73
Hemangioma, Capillary 44
Hemangioma Capillary 55
Juvenile Hemangioma 12
Strawberry Nevus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2725
ICD10 33 Q82.5
MeSH 44 D018324
NCIt 50 C6645
KEGG 37 H01482
UMLS 73 C0206733

Summaries for Capillary Hemangioma

MalaCards based summary : Capillary Hemangioma, also known as strawberry nevus of skin, is related to pyogenic granuloma and hemangioma, capillary infantile. An important gene associated with Capillary Hemangioma is TEK (TEK Receptor Tyrosine Kinase), and among its related pathways/superpathways are VEGF signaling pathway and MAPK signaling pathway. The drugs Timolol and Ephedrine have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and spinal cord, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 A capillary hemangioma (also known as an Infantile hemangioma,Strawberry hemangioma, and Strawberry... more...

Related Diseases for Capillary Hemangioma

Diseases in the Capillary Hemangioma family:

Hemangioma, Capillary Infantile

Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 pyogenic granuloma 33.5 TEK VEGFA
2 hemangioma, capillary infantile 32.1 ANTXR1 KDR
3 clear cell renal cell carcinoma 29.2 KDR SLC2A1 VEGFA
4 hemangioma 27.9 ANTXR1 KDR PECAM1 PROX1 SLC2A1 TEK
5 breast capillary hemangioma 12.1
6 angioma, tufted 11.3
7 capillary malformations, congenital 11.2
8 cerebral cavernous malformations 11.0
9 intramuscular hemangioma 10.6 SLC2A1 TEK
10 retinitis 10.5
11 chronic myocardial ischemia 10.5 TEK VEGFA
12 pediatric angiosarcoma 10.4 HBA1 VEGFA
13 hypoglycemic coma 10.4 HBA1 VEGFA
14 glomeruloid hemangioma 10.4 HBA1 VEGFA
15 hemangioendothelioma 10.4 KDR PECAM1
16 hydrocele 10.4 PECAM1 VEGFA
17 pulmonary vein stenosis 10.4 KDR PECAM1
18 renal pelvis carcinoma 10.4 SLC2A1 VEGFA
19 capillary lymphangioma 10.4 HBA1 PROX1
20 acquired hemangioma 10.3 HBA1 PROX1
21 angiokeratoma of fordyce 10.3 HBA1 PROX1
22 venous malformations, multiple cutaneous and mucosal 10.3 RASA1 TEK
23 diabetic macular edema 10.3 TEK VEGFA
24 senile angioma 10.3 HBA1 KDR
25 interstitial emphysema 10.3 HBA1 PROX1
26 juvenile nasopharyngeal angiofibroma 10.3 PECAM1 VEGFA
27 cardiovascular organ benign neoplasm 10.2 HBA1 SLC2A1 TEK
28 benign perivascular tumor 10.2 HBA1 SLC2A1 TEK
29 glomangioma 10.2 HBA1 SLC2A1 TEK
30 telangiectasis 10.2 RASA1 VEGFA
31 kuhnt-junius degeneration 10.1 KDR VEGFA
32 acute hemorrhagic leukoencephalitis 10.1 KDR VEGFA
33 leukostasis 10.1 KDR VEGFA
34 coats disease 10.1 KDR VEGFA
35 retinal detachment 10.0
36 arteriovenous malformation 10.0 RASA1 VEGFA
37 cervicitis 10.0
38 degeneration of macula and posterior pole 10.0 KDR VEGFA
39 radiation proctitis 9.9 KDR PECAM1 VEGFA
40 renal cell carcinoma, nonpapillary 9.9
41 central nervous system hemangioma 9.9
42 mediastinitis 9.9
43 endotheliitis 9.9
44 epithelioid hemangioendothelioma 9.9 KDR PECAM1 VEGFA
45 corneal neovascularization 9.9 KDR TEK VEGFA
46 limb ischemia 9.9 KDR TEK VEGFA
47 epileptic encephalopathy, childhood-onset 9.9 KDR VEGFA
48 placental insufficiency 9.9 KDR TEK VEGFA
49 exudative vitreoretinopathy 1 9.9 KDR TEK VEGFA
50 microvascular complications of diabetes 5 9.9 KDR TEK VEGFA

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to Capillary Hemangioma

Symptoms & Phenotypes for Capillary Hemangioma

MGI Mouse Phenotypes related to Capillary Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 PECAM1 PROX1 RASA1 TEK VEGFA ANTXR1
2 cellular MP:0005384 9.7 PECAM1 PROX1 RASA1 SLC2A1 VEGFA ANTXR1
3 muscle MP:0005369 9.43 PECAM1 PROX1 RASA1 TEK VEGFA KDR
4 no phenotypic analysis MP:0003012 9.02 RASA1 SLC2A1 VEGFA ANTXR1 KDR

Drugs & Therapeutics for Capillary Hemangioma

Drugs for Capillary Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 137)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Timolol Approved Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 26839-75-8 33624 5478
2
Ephedrine Approved Phase 3 299-42-3 9294
3
Pseudoephedrine Approved Phase 3 90-82-4 7028
4
Propranolol Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 525-66-6 4946
5
Nadolol Approved Phase 3,Phase 2 42200-33-9 39147
6
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
7
Atenolol Approved Phase 3 29122-68-7 2249
8
Acebutolol Approved, Investigational Phase 3 37517-30-9 1978
9 tannic acid Approved, Nutraceutical Phase 3
10
Maleic acid Experimental Phase 3,Phase 2,Phase 1,Not Applicable 110-16-7 444266
11 Adrenergic Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Adrenergic Antagonists Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Adrenergic beta-Antagonists Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Anti-Arrhythmia Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Antihypertensive Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Autonomic Agents Phase 3,Phase 2
18 Nasal Decongestants Phase 3
19 Ophthalmic Solutions Phase 3,Not Applicable
20 Peripheral Nervous System Agents Phase 3,Phase 2
21 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
22 Respiratory System Agents Phase 3
23 Tetrahydrozoline Phase 3
24 Vasoconstrictor Agents Phase 3
25 Vasodilator Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
26 Sympatholytics Phase 3,Phase 2
27 Adrenergic beta-1 Receptor Antagonists Phase 3
28 Adrenergic Agonists Phase 3
29 Adrenergic alpha-2 Receptor Agonists Phase 3
30 Adrenergic alpha-Agonists Phase 3
31 Brimonidine Tartrate Phase 3 70359-46-5
32
Bosentan Approved, Investigational Phase 2 147536-97-8 104865
33
Prednisone Approved, Vet_approved Phase 2,Not Applicable 53-03-2 5865
34
Imiquimod Approved, Investigational Phase 2,Not Applicable 99011-02-6 57469
35
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
36
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
37
Everolimus Approved Phase 2,Phase 1,Not Applicable 159351-69-6 6442177
38
Miconazole Approved, Investigational, Vet_approved Phase 2,Phase 1,Not Applicable 22916-47-8 4189
39
Sirolimus Approved, Investigational Phase 2,Phase 1,Not Applicable 53123-88-9 5284616 6436030 46835353
40
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
41
Ranibizumab Approved Phase 1, Phase 2 347396-82-1 459903
42
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
43
Ranitidine Approved Phase 2 66357-59-3, 66357-35-5 3001055
44
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
45 Strawberry Approved, Nutraceutical Phase 2
46
Histidine Approved, Nutraceutical Phase 1, Phase 2 71-00-1 6274
47 Endothelin Receptor Antagonists Phase 2
48 Anti-Inflammatory Agents Phase 2,Not Applicable
49 Antineoplastic Agents, Hormonal Phase 2,Not Applicable
50 glucocorticoids Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 84)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Hemoporfin PDT in Children With Port-wine Stain Recruiting NCT03125057 Phase 4 Hemoporfin PDT
2 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Recruiting NCT03181984 Phase 4 Hemoporfin
3 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3 Timolol + LCP
4 Topical Timolol for Superficial Infantile Hemangioma Unknown status NCT01685398 Phase 3 0.5% timolol maleate eye drop;Normal saline
5 Study to Demonstrate the Efficacy and Safety of Propranolol Oral Solution in Infants With Proliferating Infantile Hemangiomas Requiring Systemic Therapy Completed NCT01056341 Phase 2, Phase 3 Propranolol;Placebo
6 Nadolol Versus Propranolol in Children With Infantile Hemangiomas Recruiting NCT02505971 Phase 3 Nadolol;Propranolol
7 Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas Recruiting NCT03237637 Phase 3 oral propranolol;oral atenolol
8 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Recruiting NCT02342275 Phase 3 Propranolol;Atenolol
9 Onreltea (Brimonidine) Gel In Pediatric Patients With Capillary Malformations Recruiting NCT02764411 Phase 3 Brimonidine 0.33% gel
10 MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients Not yet recruiting NCT02962947 Phase 2, Phase 3 Propranolol;Placebo
11 Effectiveness and Safety of Intense Pulsed Light in Patients With Meibomian Gland Dysfunction Not yet recruiting NCT03518398 Phase 3
12 Propranolol in Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3 propranolol treatment;placebo treatment
13 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3 Acebutolol;Propanolol
14 Topical Timolol for Infantile Hemangioma in Early Proliferative Phase Unknown status NCT02731287 Phase 2 Timolol;Placebo
15 Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo Completed NCT01512173 Phase 2 propranolol gel;Placebo
16 Treatment of Resistant Port-wine Stains With Bosentan and Pulsed Dye Laser: a Pilot Study Completed NCT02317679 Phase 2 Bosentan
17 Nadolol for Proliferating Infantile Hemangiomas Completed NCT01010308 Phase 2 Nadolol
18 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2 timolol maleate 0.5% gel
19 Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Infantile Hemangioma Completed NCT01072045 Phase 2 Propranolol;Prednisone
20 Measurement Skin Temperature During Pulsed Laser Exposure Completed NCT00540917 Phase 2
21 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream
22 Efficacy, Safety and Pharmacokinetics of Topical Timolol in Infants With Infantile Hemangioma (IH) Recruiting NCT02913612 Phase 2 0.25% Timolol Maleate Gel Forming Solution;0.5% Timolol Maleate Gel Forming Solution
23 Electrosclerotherapy for Capillary Malformations Recruiting NCT02883023 Phase 2 Intralesional bleomycin injection
24 A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab Active, not recruiting NCT02859441 Phase 1, Phase 2 Ranibizumab;E10030
25 Dose-Finding of Propranolol in Combination With Metronomic Fixed Oral Cyclophosphamide Based on Bivariate Efficacy-tolerability Outcome in Patients With Locally Advanced or Metastatic Angiosarcoma: A Collaborative and Innovative Phase I-II Sequential Tria Not yet recruiting NCT02732678 Phase 1, Phase 2 PROPRANOLOL
26 The Effects of Aldara as an Adjunct to Laser Treatment Terminated NCT00979550 Phase 2 Imiquimod;non-medicated petroleum cream
27 Corticosteroids With Placebo Versus Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH) Terminated NCT01074437 Phase 2 Prednisolone (Corticosteroid);Propranolol;Placebo
28 Clinical Trial of Vincristine vs. Prednisolone for Treatment of Complicated Hemangiomas Terminated NCT00555464 Phase 2 Vincristine;Prednisone
29 Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00969397 Phase 1, Phase 2 Topical Antiangiogenic
30 Timolol Option for Ulcerated Hemangiomas (TOUCH Trial) Withdrawn NCT01408056 Phase 2 Timolol 0.5% Gel Forming Solution (GFS);Mupirocin 2% Ointment
31 Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS) Withdrawn NCT01997255 Phase 2 Everolimus
32 A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks. Completed NCT00800722 Phase 1 Rapamycin Treatment of Port Wine Stain
33 A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks. Completed NCT00830466 Phase 1 Laser and rapamycin versus laser alone
34 Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths Completed NCT00573729 Phase 1
35 Treatment of Vascular Lesions With a Tandem 532/1064 nm Laser Completed NCT00585338 Phase 1
36 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
37 Novel Treatment for Port Wine Stain Birthmarks Recruiting NCT01924273 Phase 1 Talaporfin sodium
38 Timolol for the Prevention of Proliferation of Infantile Hemangioma (TiPPIH Trial) Terminated NCT01434849 Phase 1 topical 0.5% Timolol maleate;Control (placebo) group
39 Combined Alexandrite and Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks Withdrawn NCT00580944 Phase 1
40 Combined Pulsed Dye Laser and Topical Ranibizumab for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00667472 Phase 1 Ranibizumab
41 Pilot Study on the Use of the Matrix Radiofrequencyfor Treatment of Port Wine Stain Birthmarks Withdrawn NCT01166919 Phase 1
42 The Angioma's Treatment Evaluation With Laser Doppler Imaging (LDI) Unknown status NCT01759082
43 Evaluation and Optimization of the Technical and Clinical Performance of the Lumenis ONE Platform Unknown status NCT00247299 Not Applicable
44 Clinical Characteristics of Lip Hemangiomas Unknown status NCT02351245
45 A Prospective Study Comparing the Incidence of Infantile Hemangiomas Following Normal Pregnancies Versus Pregnancies Complicated by Placental Abnormalities Unknown status NCT00490607
46 Assessing the Effects of Air-cooling on Capillary Malformations Unknown status NCT01735734
47 Monitoring the Response of Port Wine Stain Birthmarks to Laser Therapy With Wide-field Functional Imaging Technologies Completed NCT01333553
48 Dynamic Epidermal Cooling During Pulsed Dye Laser Treatment of Port Wine Stain Birthmark at High Fluences Completed NCT00540371
49 Port Wine Stains Treatment Matrix RF Study Completed NCT01101360 Not Applicable
50 Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains Completed NCT00556946 Not Applicable Combined Photodynamic & Pulsed Dye Laser Treatment

Search NIH Clinical Center for Capillary Hemangioma

Cochrane evidence based reviews: hemangioma, capillary

Genetic Tests for Capillary Hemangioma

Anatomical Context for Capillary Hemangioma

MalaCards organs/tissues related to Capillary Hemangioma:

41
Skin, Endothelial, Spinal Cord, Testis, Lung, Bone, Liver

Publications for Capillary Hemangioma

Articles related to Capillary Hemangioma:

(show top 50) (show all 610)
# Title Authors Year
1
Lobular capillary hemangioma of the mandible: A case report. ( 29704808 )
2018
2
Prolonged growth of infantile hemangioma after pulsed dye laser and oral propranolol treatment. ( 29952019 )
2018
3
Role of thrombospondin-1 and nuclear factor-kappa B signaling pathways in anti-angiogenesis of infantile hemangioma. ( 29927834 )
2018
4
Tocolysis with the I^<sub>2</sub>-sympathomimetic fenoterol does not increase the occurrence of infantile hemangioma in preterm and term infants. ( 29938346 )
2018
5
Multimodal Imaging of Optic Nerve Head Capillary Hemangioma. ( 29864074 )
2018
6
Capillary hemangioma associated with dermal atrophy masquerading as a deep fungal infection. ( 29634891 )
2018
7
Cervical corpectomy for resection of ventral intramedullary capillary hemangioma with circumferential involvement of the anterior spinal artery: case report. ( 29726799 )
2018
8
Subcutaneous Lobular Capillary Hemangioma Presenting as a Facial Mass. ( 29854524 )
2018
9
Venous outlet syndrome caused by capillary hemangioma of the subclavian vein. ( 29444598 )
2018
10
Solitary Retinal Capillary Hemangioma with Nonlipid Exudative Retinal Detachment. ( 29389404 )
2018
11
Risk of infantile hemangiomas in the offspring of women with autoimmune disease and the pathogenic implications of these lesions. ( 29341431 )
2018
12
Treatment of retinal capillary hemangioma using 810 nm infrared laser. ( 29765174 )
2018
13
Curcumin induces apoptosis and inhibits proliferation in infantile hemangioma endothelial cells via downregulation of MCL-1 and HIF-1I+. ( 29443732 )
2018
14
I^-Adrenoceptor Blockade for Infantile Hemangioma Therapy: Do I^3-Adrenoceptors Play a Role? ( 29936502 )
2018
15
Long-Term Therapeutic Outcomes of Photodynamic Therapy-Based or Photocoagulation-Based Treatments on Retinal Capillary Hemangioma. ( 29068750 )
2018
16
Combined Oral and Topical Beta Blockers for the Treatment of Early Proliferative Superficial Periocular Infantile Capillary Hemangioma. ( 28991344 )
2018
17
Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma. ( 29561329 )
2018
18
Factors associated with delayed referral for infantile hemangioma necessitating propranolol. ( 29405477 )
2018
19
Capillary Hemangioma as an Unusual Cause of Doughnut Sign on Bone Scan. ( 29742594 )
2018
20
INTRAVITREAL INJECTION OF PROPRANOLOL FOR THE TREATMENT OF RETINAL CAPILLARY HEMANGIOMA IN A CASE OF VON HIPPEL-LINDAU. ( 29466252 )
2018
21
A Rare Case of Gallbladder and Common Bile Duct Benign Capillary Hemangioma in a Toddler. ( 29652727 )
2018
22
SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA. ( 28358746 )
2017
23
A Case of Giant Intradural Extramedullary Capillary Hemangioma. ( 28091424 )
2017
24
Current perspectives on the optimal management of infantile hemangioma. ( 29388636 )
2017
25
Expression and association of VEGF-Notch pathways in infantile hemangiomas. ( 29042972 )
2017
26
Lobular capillary hemangioma (pyogenic granuloma) of the oral cavity. ( 28719705 )
2017
27
In Vivo Microvascular Pattern of Solitary Juxtapapillary Capillary Hemangioma on OCT Angiography. ( 28728187 )
2017
28
Unusual Case of Acquired Capillary Hemangioma of the Eyelid in an Adult. ( 29264305 )
2017
29
Common Skin Conditions in Children: Congenital Melanocytic Nevi and Infantile Hemangiomas. ( 28196319 )
2017
30
Intradural-extramedullary capillary hemangioma with acute bleeding, case report and literature review. ( 28823662 )
2017
31
Pediatric Intranasal Lobular Capillary Hemangioma: A Rare Clinical Entity. ( 29215342 )
2017
32
Association of ATF4 Expression With Tissue Hypoxia and M2 Macrophage Infiltration in Infantile Hemangioma. ( 28438094 )
2017
33
Capillary Hemangioma of the Tympanic Membrane and External Auditory Canal. ( 28106702 )
2017
34
Mimickers of Infantile Hemangiomas. ( 28523875 )
2017
35
Capillary Hemangioma of the Tympanic Membrane. ( 28349759 )
2017
36
Capillary Hemangioma of Thoracic Spinal Cord: PET/CT and MR Findings. ( 28195909 )
2017
37
Capillary Hemangioma of the Tympanic Membrane and External Auditory Canal. ( 28468198 )
2017
38
Concurrent Sturge-Weber syndrome, facial infantile hemangioma, and cutis marmorata telangiectatica congenita. ( 29136059 )
2017
39
Nasal Lobular Capillary Hemangioma as a Complication after an Endoscopic Transsphenoidal Gonadotrophin-Producing Pituitary Adenoma Resection. ( 28326242 )
2017
40
Subcutaneous Lobular Capillary Hemangioma on 68Ga-PSMA PET/CT. ( 28114225 )
2017
41
Challenging Pitfalls and Mimickers in Diagnosing Anastomosing Capillary Hemangioma of the Kidney: Case Report and Literature Review. ( 28286335 )
2017
42
The pigment epithelium-derived factor (PEDF): an important potential therapeutic agent for infantile hemangioma. ( 28197761 )
2017
43
Spinal epidural capillary hemangioma: A rare case report with a review of literature. ( 28713627 )
2017
44
Localised longitudinal erythronychia caused by subungual capillary hemangioma. ( 28726279 )
2017
45
Rapidly enlarging acquired capillary hemangioma of the eyelid. ( 28400395 )
2017
46
Mechanisms of Action of MicroRNAs in Infantile Hemangioma Tissue and Vascular Endothelial Cells in Different Periods. ( 28862249 )
2017
47
A Rare Cause of Hemoptysis in Childhood: Tracheal Capillary Hemangioma. ( 29404177 )
2017
48
Congenital capillary hemangioma arising from palpebral conjunctiva of a neonate. ( 29133659 )
2017
49
Conjunctival Capillary Hemangioma. ( 29392104 )
2017
50
Prevalence and pattern of lobular capillary hemangioma in Eastern Madhya Pradesh, India: A clinicopathological analysis. ( 28836535 )
2017

Variations for Capillary Hemangioma

Cosmic variations for Capillary Hemangioma:

9
(show all 14)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM584 NRAS soft tissue,skin,haemangioma,capillary c.182A>G p.Q61R 1:114713908-114713908 7
2 COSM580 NRAS soft tissue,skin,haemangioma,capillary c.181C>A p.Q61K 1:114713909-114713909 7
3 COSM529 KRAS soft tissue,skin,haemangioma,capillary c.37G>C p.G13R 12:25245348-25245348 7
4 COSM521 KRAS soft tissue,skin,haemangioma,capillary c.35G>A p.G12D 12:25245350-25245350 7
5 COSM516 KRAS soft tissue,skin,haemangioma,capillary c.34G>T p.G12C 12:25245351-25245351 7
6 COSM487 HRAS soft tissue,skin,haemangioma,capillary c.37G>A p.G13S 11:534286-534286 7
7 COSM6503574 HRAS soft tissue,skin,haemangioma,capillary c.145G>A p.E49K 11:533911-533911 7
8 COSM486 HRAS soft tissue,skin,haemangioma,capillary c.37G>C p.G13R 11:534286-534286 7
9 COSM6503575 HRAS soft tissue,skin,haemangioma,capillary c.44G>A p.G15D 11:534279-534279 7
10 COSM499 HRAS soft tissue,skin,haemangioma,capillary c.182A>G p.Q61R 11:533874-533874 7
11 COSM6503576 HRAS soft tissue,skin,haemangioma,capillary c.100C>T p.P34S 11:534223-534223 7
12 COSM52975 GNAQ soft tissue,skin,haemangioma,capillary c.548G>A p.R183Q 9:77797577-77797577 7
13 COSM476 BRAF soft tissue,skin,haemangioma,capillary c.1799T>A p.V600E 7:140753336-140753336 7
14 COSM449 BRAF soft tissue,skin,haemangioma,capillary c.1391G>A p.G464E 7:140781617-140781617 7

Expression for Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for Capillary Hemangioma

Pathways related to Capillary Hemangioma according to KEGG:

37
# Name Kegg Source Accession
1 VEGF signaling pathway hsa04370

Pathways related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.46 KDR RASA1 TEK VEGFA
2
Show member pathways
12.38 KDR RASA1 TEK VEGFA
3
Show member pathways
12.09 KDR RASA1 VEGFA
4 11.8 KDR PECAM1 VEGFA
5 11.7 KDR PROX1 VEGFA
6
Show member pathways
11.6 KDR RASA1 VEGFA
7 11.5 SLC2A1 TEK VEGFA
8
Show member pathways
11.4 KDR RASA1 VEGFA
9 11.27 KDR VEGFA
10 11.27 HBA1 PECAM1
11 11.23 KDR VEGFA
12
Show member pathways
11.18 KDR VEGFA
13 11.17 KDR VEGFA
14 11.1 RASA1 TEK
15 11.08 SLC2A1 VEGFA
16 10.87 KDR PECAM1 PROX1 TEK
17 10.86 KDR SLC2A1 VEGFA
18
Show member pathways
10.66 KDR VEGFA
19 10.51 KDR TEK VEGFA

GO Terms for Capillary Hemangioma

Cellular components related to Capillary Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 KDR PECAM1 SLC2A1 TEK

Biological processes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.8 KDR RASA1 TEK VEGFA
2 angiogenesis GO:0001525 9.72 KDR TEK VEGFA
3 positive regulation of protein phosphorylation GO:0001934 9.65 KDR TEK VEGFA
4 regulation of cell shape GO:0008360 9.63 KDR RASA1 VEGFA
5 positive regulation of angiogenesis GO:0045766 9.61 KDR TEK VEGFA
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.57 KDR VEGFA
7 substrate adhesion-dependent cell spreading GO:0034446 9.56 ANTXR1 TEK
8 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 KDR TEK
9 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.52 KDR VEGFA
10 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.51 KDR VEGFA
11 vasculogenesis GO:0001570 9.43 KDR RASA1 VEGFA
12 cell migration involved in sprouting angiogenesis GO:0002042 9.4 KDR VEGFA
13 positive regulation of positive chemotaxis GO:0050927 9.37 KDR VEGFA
14 positive regulation of focal adhesion assembly GO:0051894 9.33 KDR TEK VEGFA
15 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.32 KDR VEGFA
16 positive regulation of endothelial cell proliferation GO:0001938 9.26 KDR PROX1 TEK VEGFA
17 positive regulation of endothelial cell migration GO:0010595 8.92 KDR PROX1 TEK VEGFA

Molecular functions related to Capillary Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 8.62 KDR TEK

Sources for Capillary Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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