MCID: CPL006
MIFTS: 53

Capillary Hemangioma

Categories: Cardiovascular diseases, Genetic diseases, Skin diseases

Aliases & Classifications for Capillary Hemangioma

MalaCards integrated aliases for Capillary Hemangioma:

Name: Capillary Hemangioma 12 6 15
Strawberry Nevus of Skin 12 70
Infantile Hemangioma 12 36
Cellular Hemangioma of Infancy 12
Congenital Vascular Hamartoma 12
Congenital Vascular Naevus 12
Strawberry Haemangioma 12
Hemangioma, Cavernous 70
Hemangioma, Capillary 44
Hemangioma Capillary 54
Juvenile Hemangioma 12
Strawberry Nevus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2725
KEGG 36 H01482
MeSH 44 D018324
NCIt 50 C7457
SNOMED-CT 67 56975005
ICD10 32 Q82.5
UMLS 70 C0018920 C0206733

Summaries for Capillary Hemangioma

KEGG : 36 Infantile hemangiomas (IH) are neoplastic proliferations of vascular endothelial cells (ECs), characterized by a period of growth after birth, and eventual spontaneous involution. Forty percent of the lesions are associated with complications such as ulceration, bleeding, infection, pain, cardiac failure, airway compromise or eye impairment. Pathogenesis of IH is still shrouded in mystery even though various theories have been postulated to explain its origin. Recent studies provide strong evidence for the conclusion that the VEGF receptor 2 (VEGFR2) and Tumor Endothelial Marker 8 (TEM8) mutations represent risk factor mutations for hemangioma formation. In the proliferating phase, constitutive VEGFR2 signaling in ECs from hemangioma lesions affects downstream processes, including EC proliferation and migration, providing a mechanistic explanation for the rapid endothelial proliferation seen in hemangioma.

MalaCards based summary : Capillary Hemangioma, also known as strawberry nevus of skin, is related to pyogenic granuloma and hemangioma, capillary infantile. An important gene associated with Capillary Hemangioma is ARID1B (AT-Rich Interaction Domain 1B), and among its related pathways/superpathways are VEGF signaling pathway and ERK Signaling. The drugs Captopril and Maleic acid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, skin and eye, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 73 A capillary hemangioma (also known as an Infantile hemangioma, Strawberry hemangioma, and Strawberry... more...

Related Diseases for Capillary Hemangioma

Diseases in the Capillary Hemangioma family:

Hemangioma, Capillary Infantile

Diseases related to Capillary Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 411)
# Related Disease Score Top Affiliating Genes
1 pyogenic granuloma 33.0 TEK GNA14
2 hemangioma, capillary infantile 31.8 KDR FLT4 ANTXR1
3 macular retinal edema 30.8 VEGFA KDR FLT1
4 cavernous hemangioma 30.6 PECAM1 KDR FGF2 CD34
5 central nervous system hemangioma 30.6 VEGFA PECAM1 CD34
6 hemangioendothelioma 30.5 FLT4 CD34
7 breast hemangioma 30.3 PECAM1 CD34
8 arteriovenous malformation 30.3 VEGFA TEK RASA1
9 angiolipoma 30.2 PECAM1 CD34
10 vascular cancer 30.1 VEGFA PECAM1 KDR FLT4 FLT1 FGF2
11 epithelioid hemangioendothelioma 30.1 VEGFA KDR FLT1
12 pericardial effusion 30.1 VEGFA FGF2 CD34
13 retinal artery occlusion 30.1 VEGFA KDR FLT1
14 hydrocele 30.1 VEGFA PECAM1 FLT4
15 meningioma, familial 30.1 VEGFA SLC2A1 RASA1 FLT1 CD34 AKT3
16 sturge-weber syndrome 30.0 SYNGAP1 RASA1 GNA14
17 neovascular glaucoma 29.9 VEGFA KDR FLT1 FGF2
18 clear cell renal cell carcinoma 29.9 VHL VEGFA SLC2A1 PECAM1 KDR FLT1
19 kaposiform hemangioendothelioma 29.8 PROX1 PECAM1 KDR GNA14 FLT4 CD34
20 wilms tumor 1 29.8 VHL VEGFA SLC2A1 FLT1 CD34
21 angiosarcoma 29.8 VEGFA TEK PROX1 PECAM1 KDR FLT4
22 placental insufficiency 29.7 VEGFA TEK KDR FLT1 FGF2
23 retinal vascular disease 29.7 VEGFA TEK KDR FLT1 FGF2
24 rhabdomyosarcoma 29.7 VEGFA PROM1 KDR FLT1 FGF2
25 microvascular complications of diabetes 5 29.7 VEGFA TEK KDR FLT1 FGF2
26 hemangioblastoma 29.7 VHL VEGFA SLC2A1 PROM1 PECAM1 KDR
27 hemangioma 29.7 VHL VEGFA TEK SLC2A1 PROX1 PROM1
28 intussusception 29.7 VEGFA TEK PECAM1 KDR FLT1 FGF2
29 pre-eclampsia 29.6 VEGFA PECAM1 KDR FLT1 ADRB2
30 intramuscular hemangioma 29.6 TEK PROX1 PECAM1 LYVE1 CD34
31 exudative vitreoretinopathy 1 29.6 VEGFA TEK PECAM1 KDR FLT1 FGF2
32 klippel-trenaunay-weber syndrome 29.5 TEK SYNGAP1 RASA1 FLT4
33 renal cell carcinoma, nonpapillary 29.4 VHL VEGFA TEK SLC2A1 PECAM1 KDR
34 lymphangioma 29.1 VEGFA PROX1 PECAM1 LYVE1 KDR FLT4
35 heart disease 28.8 VEGFA TEK PECAM1 KDR FLT4 FLT1
36 breast capillary hemangioma 11.4
37 capillary malformations, congenital 11.2
38 angioma, tufted 11.1
39 non-involuting congenital hemangioma 11.1
40 infantile hemangioma of rare localization 11.0
41 von hippel-lindau syndrome 10.5
42 retinal detachment 10.4
43 skin epithelioid hemangioma 10.4 PECAM1 CD34
44 aortic malignant tumor 10.4 PECAM1 CD34
45 central nervous system angiosarcoma 10.4 PECAM1 CD34
46 intravascular angioleiomyoma 10.4 PECAM1 CD34
47 suppression amblyopia 10.4
48 amblyopia 10.4
49 heart fibrosarcoma 10.4 PECAM1 CD34
50 ovarian angiosarcoma 10.4 PECAM1 CD34

Graphical network of the top 20 diseases related to Capillary Hemangioma:



Diseases related to Capillary Hemangioma

Symptoms & Phenotypes for Capillary Hemangioma

GenomeRNAi Phenotypes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 10.43 GNA14
2 Decreased viability GR00221-A-1 10.43 AKT3 KDR VHL
3 Decreased viability GR00221-A-2 10.43 AKT3 FLT1 FLT4 KDR VHL
4 Decreased viability GR00221-A-3 10.43 AKT3 KDR RASA1 TEK
5 Decreased viability GR00221-A-4 10.43 AKT3 KDR RASA1
6 Decreased viability GR00249-S 10.43 FGF2 KDR VEGFA VHL
7 Decreased viability GR00301-A 10.43 AKT3 VHL
8 Decreased viability GR00342-S-1 10.43 FLT4
9 Decreased viability GR00342-S-2 10.43 ADRB2 FLT4
10 Decreased viability GR00342-S-3 10.43 ADRB2 FLT4
11 Decreased viability GR00381-A-1 10.43 ADRB2 ARID1B GNA14 RASA1
12 Decreased viability GR00381-A-3 10.43 ADRB2
13 Decreased viability GR00386-A-1 10.43 FGF2 FLT4 GNA14 RASA1 SLC2A1 SYNGAP1
14 Decreased viability GR00402-S-2 10.43 TEK
15 Increased the percentage of infected cells GR00402-S-1 8.32 ADRB2

MGI Mouse Phenotypes related to Capillary Hemangioma:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.43 ADRB2 AKT3 ANTXR1 ARID1B FGF2 FLT1
2 cellular MP:0005384 10.41 ADRB2 AKT3 ANTXR1 CD34 FGF2 FLT1
3 growth/size/body region MP:0005378 10.37 ADRB2 AKT3 ANTXR1 ARID1B FLT1 FLT4
4 behavior/neurological MP:0005386 10.31 ADRB2 AKT3 ARID1B FGF2 FLT1 KDR
5 homeostasis/metabolism MP:0005376 10.3 ADRB2 AKT3 ARID1B CD34 FGF2 FLT1
6 hematopoietic system MP:0005397 10.29 ADRB2 AKT3 ARID1B CD34 FGF2 FLT1
7 immune system MP:0005387 10.28 ADRB2 AKT3 ANTXR1 ARID1B CD34 FLT1
8 mortality/aging MP:0010768 10.28 AKT3 ANTXR1 ARID1B FGF2 FLT1 FLT4
9 muscle MP:0005369 10.15 ADRB2 ARID1B FGF2 FLT1 FLT4 KDR
10 nervous system MP:0003631 10.07 ADRB2 AKT3 ARID1B FGF2 FLT1 KDR
11 neoplasm MP:0002006 9.87 AKT3 ANTXR1 CD34 FGF2 PROM1 VEGFA
12 no phenotypic analysis MP:0003012 9.76 ADRB2 ANTXR1 FLT4 KDR PROM1 RASA1
13 normal MP:0002873 9.61 AKT3 FLT1 FLT4 KDR PROM1 PROX1
14 vision/eye MP:0005391 9.32 ADRB2 FGF2 FLT1 KDR PROM1 PROX1

Drugs & Therapeutics for Capillary Hemangioma

Drugs for Capillary Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Captopril Approved Phase 4 62571-86-2 44093
2
Maleic acid Experimental Phase 4 110-16-7 444266
3 Anesthetics Phase 4
4 Ophthalmic Solutions Phase 4
5 Angiotensin-Converting Enzyme Inhibitors Phase 4
6
protease inhibitors Phase 4
7 HIV Protease Inhibitors Phase 4
8
Timolol Approved Phase 3 26839-75-8 33624 5478
9
Nadolol Approved Phase 3 42200-33-9 39147
10
Atenolol Approved Phase 3 29122-68-7 2249
11
tannic acid Approved Phase 3 1401-55-4
12
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
13
Propranolol Approved, Investigational Phase 2, Phase 3 525-66-6 4946
14
Acebutolol Approved, Investigational Phase 3 37517-30-9 1978
15 Sympatholytics Phase 3
16 Vasodilator Agents Phase 2, Phase 3
17 Sympathomimetics Phase 3
18 Adrenergic beta-1 Receptor Antagonists Phase 3
19
Bosentan Approved, Investigational Phase 2 147536-97-8 104865
20
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
21 Strawberry Approved Phase 2
22
Atorvastatin Approved Phase 1, Phase 2 134523-00-5 60823
23
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
24
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
25
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
26
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
27
Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
28
Ranitidine Approved, Withdrawn Phase 2 66357-35-5, 66357-59-3, 82530-72-1 3001055
29
Imiquimod Approved, Investigational Phase 2 99011-02-6 57469
30
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
31 Endothelin Receptor Antagonists Phase 2
32 Anticholesteremic Agents Phase 1, Phase 2
33 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
34 Antimetabolites Phase 1, Phase 2
35 Lipid Regulating Agents Phase 1, Phase 2
36 Hypolipidemic Agents Phase 1, Phase 2
37 Anti-Arrhythmia Agents Phase 2
38 Adrenergic Antagonists Phase 2
39 Antihypertensive Agents Phase 2
40 Neurotransmitter Agents Phase 2
41 Adrenergic beta-Antagonists Phase 2
42 Adrenergic Agents Phase 2
43 Hormone Antagonists Phase 2
44 Hormones Phase 2
45 Methylprednisolone Acetate Phase 2
46 glucocorticoids Phase 2
47 Antiviral Agents Phase 2
48 Anti-Inflammatory Agents Phase 2
49 Antineoplastic Agents, Hormonal Phase 2
50 Ranitidine bismuth citrate Phase 2

Interventional clinical trials:

(show top 50) (show all 87)
# Name Status NCT ID Phase Drugs
1 A Pilot Study of Hemoporfin Photodynamic Therapy in Children (7-14 Years Old) With Port-wine Stain Completed NCT03125057 Phase 4 Hemoporfin PDT
2 Evaluation of the Efficacy of Captopril Versus Propranolol and Timolol as a Treatment of Infantile Capillary Hemangioma Recruiting NCT04288700 Phase 4 oral propranolol;Oral Captopril;intralesional propranolol injection;topical Timolol maleate 0.5% eye drops
3 Postmarketing Safety Study of Hemoporfin in Patients With Port Wine Stain Recruiting NCT03181984 Phase 4 Hemoporfin
4 A Pilot Study of Hemoporfin Photodynamic Therapy in Children (2-7 Years Old) With Port-wine Stain Recruiting NCT04106258 Phase 4 Hemoporfin PDT
5 Comparative Study to Evaluate the Effectiveness of Atenolol and Propranolol in the Treatment of Infantile Hemangiomas Unknown status NCT03237637 Phase 3 oral propranolol;oral atenolol
6 Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel Unknown status NCT01272609 Phase 3 Timolol + LCP
7 Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma Completed NCT02342275 Phase 3 Propranolol;Atenolol
8 A Randomised, Controlled, Multidose, Multicentre, Adaptive Phase II/III Study in Infants With Proliferating Infantile Hemangiomas (IHs) Requiring Systemic Therapy to Compare 4 Regimens of Propranolol (1 or 3 mg/kg/Day for 3 or 6 Months) to Placebo (Double Blind). Completed NCT01056341 Phase 2, Phase 3 Propranolol;Placebo
9 Nadolol Versus Propranolol in Children With Infantile Hemangiomas: a Randomized, Controlled, Double-blinded Trial Completed NCT02505971 Phase 3 Nadolol;Propranolol
10 Double Blind, Randomised, Placebo-controlled Study of Propranolol in Infantile Capillary Hemangiomas Terminated NCT00744185 Phase 2, Phase 3 propranolol treatment;placebo treatment
11 Efficacy and Safety of Propranolol Versus Acebutolol on the Proliferative Phase of Infantile Hemangioma Terminated NCT01743885 Phase 3 Acebutolol;Propanolol
12 Treat_CCM Clinical Trial A Multicenter Randomized Clinical Trial on Propranolol in Cerebral Cavernous Malformation Unknown status NCT03589014 Phase 2 Propranolol
13 Nadolol for Proliferating Infantile Hemangiomas: A Prospective Open Label Study With a Historical Control Completed NCT01010308 Phase 2 Nadolol
14 Efficacy and Safety of Topical Timolol Maleate 0.5% Solution for Superficial Infantile Hemangioma in Early Proliferative Phase. A Randomized Clinical Trial Completed NCT02731287 Phase 2 Timolol;Placebo
15 A Comparative Study of the Use of Beta Blocker and Oral Corticosteroid in the Treatment of Proliferative and Involuting Cutaneous Infantile Hemangioma Completed NCT01072045 Phase 2 Propranolol;Prednisone
16 A Randomised, Double Blind, Controlled, Multicentre Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo. Completed NCT01512173 Phase 2 propranolol gel;Placebo
17 Efficacy, Safety, and Pharmacokinetics of Timolol in Infants With Infantile Hemangioma (IH) Completed NCT02913612 Phase 2 0.25% Timolol Maleate Gel Forming Solution;0.5% Timolol Maleate Gel Forming Solution
18 Topical Timolol Gel for the Treatment of Infantile Hemangiomas Completed NCT02145884 Phase 2 timolol maleate 0.5% gel
19 A Phase II Study of Imiquimod 5 % Cream for the Treatment of Hemangioma in Infancy Completed NCT00601016 Phase 2 Imiquimod 5% cream
20 Treatment of Port-wine Stains by Bosentan in Addition to Pulsed Dye Laser (PDL) in Children or Young Adults Who Previously Failed to Respond to PDL Alone: a Monocentric Pilot Study Completed NCT02317679 Phase 2 Bosentan
21 Phase II Clinical Trial is to Compare Epidermal Temperature Measurements During 1.Laser Treatment at Standard Treatment Energies 2.Cryogen Spray Cooling (CSC) Plus Laser Treatment. 3.Contact Cooling Plus Laser Treatment. Completed NCT00540917 Phase 2
22 Phase I-II Randomized, Placebo-Controlled, Single-Blinded, Single-Site Clinical Trial of Atorvastatin in the Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
23 Effect of Oral Propranolol on mRNA Expression in Symptomatice Caavernous Malformation Active, not recruiting NCT03474614 Phase 2 Propranolol
24 '' Efficacy of Propranolol in the Treatment of Infantile Hemangioma" Not yet recruiting NCT04684667 Phase 2 Propranolol Therapy for Infantile Hemangioma
25 A Phase II, Randomized, Double-Blind Comparison of Corticosteroid and Corticosteroids With Propranolol Treatment of Infantile Hemangiomas (IH) Terminated NCT01074437 Phase 2 Prednisolone (Corticosteroid);Propranolol;Placebo
26 The Effects of Aldara as an Adjunct to Laser Treatment of Port Wine Stains Terminated NCT00979550 Phase 2 Imiquimod;non-medicated petroleum cream
27 The Efficacy of Timolol 0.5% Gel Forming Solution for the Treatment of Ulcerated Hemangiomas Withdrawn NCT01408056 Phase 2 Timolol 0.5% Gel Forming Solution (GFS);Mupirocin 2% Ointment
28 Combined Use of Pulsed Dye Laser and Topical Antiangiogenic Agents for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00969397 Phase 1, Phase 2 Topical Antiangiogenic
29 Oral Propanolol for Surgically Inaccessible Cerebral and Spinal Cavernous Malformations Unknown status NCT03523650 Phase 1 Propranolol Oral Tablet;Placebo Oral Tablet
30 Novel Treatment for Port Wine Stain Birthmarks Completed NCT01924273 Phase 1 Talaporfin sodium
31 Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks: Comparison of 577 nm Versus 595 nm Wavelengths Completed NCT00573729 Phase 1
32 Optical Clearing of the Skin in Conjunction With Laser Treatments Completed NCT00580736 Phase 1
33 A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks. Completed NCT00830466 Phase 1 Laser and rapamycin versus laser alone
34 Phase I Combined Use of Pulsed Dye Laser and Rapamycin Completed NCT00800722 Phase 1 Rapamycin Treatment of Port Wine Stain
35 Influence of Matrix Metalloproteinase on Brain Arteriovenous Malformation Hemorrhage Completed NCT00783523 Phase 1 Doxycycline or Placebo
36 Phase 1 Study of Topical Beta Blocker to Prevent the Proliferative Stage of Infantile Hemangioma Terminated NCT01434849 Phase 1 topical 0.5% Timolol maleate;Control (placebo) group
37 Pilot Study on the Use of the Matrix Radiofrequency for Treatment of Port Wine Stain Birthmarks Withdrawn NCT01166919 Phase 1
38 Combined Alexandrite and Pulsed Dye Laser Treatment of Port Wine Stain Birthmarks Withdrawn NCT00580944 Phase 1
39 Combined Pulsed Dye Laser and Topical Ranibizumab for Treatment of Port Wine Stain Birthmarks Withdrawn NCT00667472 Phase 1 Ranibizumab
40 A Prospective Study on the Incidence and Related Risk Factors of Infantile Hemangioma in China Unknown status NCT03173352
41 Optimizing Timolol Maleate Treatment of Infantile Hemangioma by Doppler Ultrasound Examination: a Single Center, Open Cohort Study. Unknown status NCT03842631 Timolol Maleate 0.5% Oph Soln
42 The Angioma's Treatment Evaluation With Laser Doppler Imaging (LDI) Unknown status NCT01759082
43 Evaluation and Optimization of the Technical and Clinical Performance of the Lumenis ONE Platform Unknown status NCT00247299
44 French National Prospective Cohort of Children With Port Wine Stain on a Limb = "Cohorte Nationale d'Enfants Avec Angiome Plan de Membre inférieur" Unknown status NCT01364857
45 A Prospective Study Comparing the Incidence of Infantile Hemangiomas Following Normal Pregnancies Versus Pregnancies Complicated by Placental Abnormalities Unknown status NCT00490607
46 Clinical Characteristics and Complications of Infantile Hemangiomas Located in Lips Unknown status NCT02351245
47 Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care Completed NCT01431326 The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
48 Ontogeny and Quantitative Multimodal Skin Imaging of Infantile Hemangiomas Completed NCT02061735
49 Optical Tomographic Imaging of Infantile Hemangiomas Completed NCT01673971
50 Prescription of Hemangiol in the Treatment of Proliferative Infantile Hemangiomas Requiring Systemic Treatment: Post Marketing Surveillance Study Completed NCT04105517

Search NIH Clinical Center for Capillary Hemangioma

Cochrane evidence based reviews: hemangioma, capillary

Genetic Tests for Capillary Hemangioma

Anatomical Context for Capillary Hemangioma

MalaCards organs/tissues related to Capillary Hemangioma:

40
Endothelial, Skin, Eye, Spinal Cord, Retina, Testis, Trachea

Publications for Capillary Hemangioma

Articles related to Capillary Hemangioma:

(show top 50) (show all 1066)
# Title Authors PMID Year
1
Benign vascular proliferations--an immunohistochemical and comparative study. 54 61
15469208 2004
2
Regression of a juxtapapillary retinal capillary hemangioma after verteporfin photodynamic therapy. 61
33390253 2021
3
Paradoxical capillary hemangioma during treatment with ramucirumab. 61
33709515 2021
4
Intradural extramedullary capillary hemangioma of the cauda equina: case report of a rare spinal tumor. 61
33741893 2021
5
Ophthalmological Aspects of von-Hippel-Lindau Syndrome. 61
33780299 2021
6
Algorithmic Approach to Fibroinflammatory Sinonasal Tract Lesions. 61
33723762 2021
7
Rare lobular capillary hemangioma associated with azacitidine in high-risk myelodysplastic syndrome patient. 61
33594760 2021
8
Juxtapapillary retinal capillary hemangioma: A clinical and histopathological case report. 61
33485171 2021
9
Inflammatory lobular hemangioma: A vascular proliferation with a prominent lymphoid component. Review of a series of 19 cases. 61
32779250 2021
10
Maxillary Sinus Lobular Capillary Hemangioma in a 15-Year-Old Boy. 61
33559499 2021
11
A refractory pleural effusion caused by a pleural capillary hemangioma. 61
33763325 2021
12
Contrast-enhanced ultrasound features of breast capillary hemangioma: a case report and review of literature. 61
33409863 2021
13
Malignant Conversion of Eyelid Capillary Hemangioma to Cutaneous Angiosarcoma. 61
33481537 2021
14
Intracranial Capillary Hemangiomas: A Peripartum Presentation and Review of the Literature. 61
32920159 2021
15
[Solitary pulmonary capillary hemangioma of adult: a series of 10 cases]. 61
33412636 2021
16
Multiple Erythematous Nodules: An Intriguing Entity. 61
33768037 2021
17
Oral pyogenic granuloma: An 18-year retrospective clinicopathological and immunohistochemical study. 61
33486806 2021
18
Lobular capillary hemangioma of the trachea - A rare cause of stridor in elderly: A case report with review of literature. 61
33297712 2020
19
Lobular Capillary Hemangioma of the Lip. 61
32917445 2020
20
A Collision between Cavernous-Capillary Hemangioma with Stromal Luteinization and Serous Cystadenoma. 61
33415926 2020
21
A capillary hemangioma of lobular subtype (pyogenic granuloma) in the calvarium of a pregnant woman. 61
32240377 2020
22
Aesthetic Treatment Outcomes of Capillary Hemangioma, Venous Lake, and Venous Malformation of the Lip Using Different Surgical Procedures and Laser Wavelengths (Nd:YAG, Er,Cr:YSGG, CO2, and Diode 980 nm). 61
33266374 2020
23
Capillary Hemangioma: An Important Consideration in the Repertoire of Spinal Tumors. 61
33161914 2020
24
[Lombosacral epidural capillary hemangioma]. 61
33739758 2020
25
Proptosis due to intraorbital space-occupying lesions in children. 61
32676791 2020
26
Intravascular Lobular Capillary Hemangioma (Intravascular Pyogenic Granuloma): A Clinicopathologic Study of 40 Cases. 61
32496432 2020
27
Papillary Endothelial Hyperplasia of Scalp with Bone Erosion: A Case Report with Review of Literature. 61
33252296 2020
28
Tiny capillary hemangioma of the ileum as the cause of chronic anemia. 61
33102781 2020
29
Photodynamic Therapy in Ocular Oncology. 61
33133446 2020
30
Intussusceptive angiogenesis and its counterpart intussusceptive lymphangiogenesis. 61
32329808 2020
31
Airway obstruction as the primary manifestation of infantile thyroid hemangioma. 61
33076956 2020
32
Meyerson Phenomenon in Lobular Capillary Hemangioma. 61
33165403 2020
33
Pulmonary Capillary Hemangioma-like Pulmonary Artery Hypertension Associated With Interferon-Alpha Therapy. 61
31977566 2020
34
Pediatric Tracheal Lobular Capillary Hemangioma: A Case Report and Review of the Literature. 61
32918757 2020
35
Endobronchial capillary hemangioma a rare cause of hemoptysis. 61
32883908 2020
36
Progressively increasing density of the solid center of a ground-glass nodule in a solitary pulmonary capillary hemangioma: A case report. 61
32372500 2020
37
Swept Source OCT Angiography of Optic Nerve Head Retinal Capillary Hemangioma. 61
32768033 2020
38
Cutaneous intravascular epithelioid hemangioma. A clinicopathological and molecular study of 21 cases. 61
32094426 2020
39
Imaging features of pathologically proven pediatric splenic masses. 61
32495175 2020
40
Diode laser-assisted management of intraoral soft tissue overgrowth: a case series. 61
32597774 2020
41
Combined brachytherapy and vitreoretinal surgery for a large retinal capillary hemangioma with exudative retinal detachment. 61
32693625 2020
42
Severe rectal bleeding caused by a small polypoid lobular capillary hemangioma. 61
31863427 2020
43
Adult Primary Capillary Hemangioma of the Sclera: A Previously Undescribed Entity With a Review of Epibulbar Vascular Lesions. 61
31895731 2020
44
Spinal Capillary Hemangioma: A Rare Benign Extradural Tumor. 61
32213223 2020
45
Epidural angiolipoma with concomitant intradural extramedullary capillary hemangioma at the same spinal level: A case report. 61
32565948 2020
46
Spinal Epidural Capillary Hemangioma With Intrathoracic Extension: Case Report and Review of the Literature. 61
32850229 2020
47
[Differential diagnosis of papilledema and macular exudation-the exophytically growing juxtapapillary retinal capillary hemangioma]. 61
32577810 2020
48
Ocular and Periocular Tumors in Asian Indian Children and Adolescents. 61
32221055 2020
49
Juxtapapillary Capillary Retinal Angioma and Epiretinal Membrane Management in a Monocular Patient with Von Hippel-Lindau Syndrome. 61
32541428 2020
50
Histopathological analysis of biopsies of "peri-implant inflammatory lesions." Everything is not what it seems. 61
32378812 2020

Variations for Capillary Hemangioma

ClinVar genetic disease variations for Capillary Hemangioma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 ARID1B NM_020732.3(ARID1B):c.5968C>T (p.Arg1990Ter) SNV Pathogenic 210306 rs797045283 GRCh37: 6:157528243-157528243
GRCh38: 6:157207109-157207109
2 AKT3 NM_005465.7(AKT3):c.1393C>T (p.Arg465Trp) SNV Likely pathogenic 39814 rs587776935 GRCh37: 1:243668598-243668598
GRCh38: 1:243505296-243505296
3 NPC1 NM_000271.5(NPC1):c.1315A>G (p.Ile439Val) SNV Uncertain significance 816923 rs933640981 GRCh37: 18:21136218-21136218
GRCh38: 18:23556254-23556254

Expression for Capillary Hemangioma

Search GEO for disease gene expression data for Capillary Hemangioma.

Pathways for Capillary Hemangioma

Pathways related to Capillary Hemangioma according to KEGG:

36
# Name Kegg Source Accession
1 VEGF signaling pathway hsa04370

Pathways related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 VHL VEGFA TEK SYNGAP1 RASA1 KDR
2
Show member pathways
13.53 TEK KDR GNA14 FLT4 FLT1 FGF2
3
Show member pathways
13.51 VEGFA TEK KDR GNA14 FLT4 FLT1
4
Show member pathways
13.38 TEK KDR GNA14 FLT4 FLT1 FGF2
5
Show member pathways
13.27 TEK SLC2A1 KDR FLT4 FLT1 FGF2
6
Show member pathways
13.04 KDR GNA14 FLT4 FLT1 FGF2 AKT3
7
Show member pathways
12.95 VEGFA TEK KDR FLT4 FLT1 FGF2
8
Show member pathways
12.91 TEK KDR GNA14 FLT4 FLT1
9
Show member pathways
12.86 VEGFA KDR FLT4 FLT1 AKT3
10 12.81 VHL VEGFA SLC2A1 FLT4 FGF2 AKT3
11 12.75 VEGFA TEK RASA1 KDR FLT4 FLT1
12
Show member pathways
12.57 VHL VEGFA SLC2A1 KDR FGF2 AKT3
13
Show member pathways
12.47 VEGFA KDR FLT1 FGF2 AKT3
14
Show member pathways
12.46 KDR FLT4 FLT1 AKT3
15
Show member pathways
12.45 VEGFA TEK SYNGAP1 RASA1 KDR FLT4
16
Show member pathways
12.4 KDR FLT4 FLT1 AKT3
17
Show member pathways
12.4 VEGFA KDR FLT4 FLT1 AKT3
18
Show member pathways
12.37 TEK RASA1 KDR FLT4 FLT1 FGF2
19
Show member pathways
12.37 VEGFA KDR FLT4 FLT1 FGF2
20
Show member pathways
12.36 VEGFA RASA1 KDR AKT3
21 12.36 VEGFA KDR GNA14 FLT4 FLT1 FGF2
22 12.27 VEGFA KDR FGF2 AKT3
23
Show member pathways
12.22 TEK KDR FLT4 FLT1 AKT3
24 12.09 TEK KDR FLT4 FLT1 FGF2
25 12.08 VEGFA PECAM1 KDR AKT3
26 12.03 VEGFA PROX1 PROM1 KDR FGF2
27
Show member pathways
11.95 VEGFA KDR GNA14 FLT1 AKT3
28 11.92 VHL VEGFA TEK SLC2A1 FLT1 AKT3
29 11.83 VEGFA TEK FLT1
30
Show member pathways
11.8 KDR FLT4 FLT1 AKT3
31 11.76 VEGFA SLC2A1 PROM1 FGF2
32
Show member pathways
11.76 VHL VEGFA RASA1 KDR FLT4 FLT1
33 11.66 SYNGAP1 RASA1 GNA14
34 11.56 VHL VEGFA SLC2A1
35 11.51 VEGFA KDR FGF2
36 11.48 VEGFA KDR FGF2
37 11.4 VEGFA KDR FLT4 FLT1 FGF2
38
Show member pathways
11.32 KDR FLT4 FLT1
39 11.19 VHL VEGFA SLC2A1 KDR FLT1
40 11.17 VEGFA FLT1 FGF2
41 11.12 TEK PROX1 PECAM1 KDR FLT4 FLT1
42 11 TEK KDR GNA14 FLT4 FLT1 FGF2
43
Show member pathways
10.96 VEGFA KDR FLT4 FLT1
44 10.73 VEGFA TEK KDR FLT1 FGF2

GO Terms for Capillary Hemangioma

Cellular components related to Capillary Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.83 TEK SYNGAP1 SLC2A1 RASA1 PROM1 PECAM1
2 apical plasma membrane GO:0016324 9.65 TEK SLC2A1 PROM1 CD34 ADRB2
3 membrane raft GO:0045121 9.62 TEK SLC2A1 PECAM1 KDR
4 receptor complex GO:0043235 9.55 TEK KDR FLT4 FLT1 ADRB2
5 integral component of plasma membrane GO:0005887 9.32 TEK SLC2A1 PROM1 PECAM1 LYVE1 KDR

Biological processes related to Capillary Hemangioma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.27 VEGFA TEK SYNGAP1 RASA1 PECAM1 GNA14
2 multicellular organism development GO:0007275 10.21 VEGFA TEK PROX1 KDR FLT4 FLT1
3 positive regulation of cell proliferation GO:0008284 10.1 VEGFA PROX1 KDR FLT4 FLT1 FGF2
4 negative regulation of apoptotic process GO:0043066 10.08 VHL VEGFA TEK RASA1 KDR FLT4
5 negative regulation of gene expression GO:0010629 10.03 VHL VEGFA KDR FGF2 CD34
6 MAPK cascade GO:0000165 10.01 TEK SYNGAP1 RASA1 FGF2
7 positive regulation of cell migration GO:0030335 9.98 VEGFA PECAM1 KDR FLT1
8 protein autophosphorylation GO:0046777 9.96 TEK KDR FLT4 FLT1
9 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.96 VEGFA TEK KDR FLT4 FGF2
10 angiogenesis GO:0001525 9.95 VEGFA TEK KDR FLT4 FLT1 FGF2
11 peptidyl-tyrosine phosphorylation GO:0018108 9.93 TEK KDR FLT4 FLT1
12 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.92 TEK KDR FLT4 FLT1
13 lung development GO:0030324 9.88 VEGFA PROX1 FGF2
14 vasculogenesis GO:0001570 9.85 VEGFA RASA1 KDR
15 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFA TEK PECAM1 KDR FLT4 FGF2
16 hematopoietic progenitor cell differentiation GO:0002244 9.84 KDR FLT4 FLT1
17 positive regulation of kinase activity GO:0033674 9.84 TEK KDR FLT4 FLT1
18 positive regulation of MAP kinase activity GO:0043406 9.83 VEGFA FLT1 FGF2
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.83 VEGFA KDR FLT4 FLT1
20 positive regulation of blood vessel endothelial cell migration GO:0043536 9.81 VEGFA KDR FGF2 AKT3
21 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.8 VEGFA TEK KDR FLT1 FGF2
22 positive regulation of angiogenesis GO:0045766 9.8 VEGFA TEK KDR FLT1 FGF2 CD34
23 sprouting angiogenesis GO:0002040 9.77 VEGFA TEK FLT4
24 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.77 TEK FLT1 FGF2
25 blood vessel morphogenesis GO:0048514 9.76 RASA1 FLT4 FLT1
26 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.76 VEGFA KDR FGF2 AKT3
27 positive regulation of focal adhesion assembly GO:0051894 9.75 VEGFA TEK KDR
28 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.73 VEGFA KDR FLT4 FLT1
29 cell migration involved in sprouting angiogenesis GO:0002042 9.72 VEGFA KDR FGF2
30 positive regulation of DNA biosynthetic process GO:2000573 9.71 VEGFA FGF2
31 endothelial cell differentiation GO:0045446 9.7 PROX1 KDR
32 positive regulation of phospholipase C activity GO:0010863 9.7 FLT1 FGF2
33 positive regulation of vasculogenesis GO:2001214 9.7 KDR CD34
34 retina morphogenesis in camera-type eye GO:0060042 9.69 PROX1 PROM1
35 positive regulation of positive chemotaxis GO:0050927 9.69 VEGFA KDR
36 lymphangiogenesis GO:0001946 9.69 PROX1 FLT4
37 lymph vessel development GO:0001945 9.68 PROX1 FLT4
38 positive regulation of protein kinase C signaling GO:0090037 9.68 VEGFA FLT4
39 stem cell proliferation GO:0072089 9.68 FGF2 CD34
40 vascular wound healing GO:0061042 9.67 VEGFA KDR CD34
41 paracrine signaling GO:0038001 9.66 FGF2 CD34
42 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.65 VEGFA KDR
43 vascular endothelial growth factor receptor-2 signaling pathway GO:0036324 9.65 VEGFA KDR
44 endothelium development GO:0003158 9.64 KDR CD34
45 positive regulation of epithelial tube formation GO:1905278 9.64 VEGFA FGF2
46 positive regulation of endothelial cell migration GO:0010595 9.63 VEGFA TEK PROX1 KDR FLT4 FGF2
47 vascular endothelial growth factor signaling pathway GO:0038084 9.62 VEGFA KDR FLT4 FLT1
48 glomerular endothelium development GO:0072011 9.61 PECAM1 CD34
49 positive regulation of MAPK cascade GO:0043410 9.5 VEGFA TEK KDR FLT4 FLT1 FGF2
50 positive regulation of endothelial cell proliferation GO:0001938 9.17 VEGFA TEK PROX1 KDR FLT4 FGF2

Molecular functions related to Capillary Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.26 VHL VEGFA TEK SYNGAP1 SLC2A1 RASA1
2 protein kinase activity GO:0004672 9.77 TEK KDR FLT4 FLT1 AKT3
3 protein tyrosine kinase activity GO:0004713 9.62 TEK KDR FLT4 FLT1
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 TEK KDR FLT4 FLT1
5 growth factor binding GO:0019838 9.26 TEK KDR FLT4 FLT1
6 vascular endothelial growth factor-activated receptor activity GO:0005021 8.8 KDR FLT4 FLT1

Sources for Capillary Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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