MCID: CPL003
MIFTS: 46

Capillary Leak Syndrome

Categories: Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Capillary Leak Syndrome

MalaCards integrated aliases for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 56 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:14400
MeSH 45 D019559
NCIt 51 C62578
SNOMED-CT 69 87730004
UMLS 74 C0343084

Summaries for Capillary Leak Syndrome

MalaCards based summary : Capillary Leak Syndrome is related to perinatal necrotizing enterocolitis and brucellosis. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. The drugs Clavulanate and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include endothelial, breast and skin, and related phenotype is neoplasm.

Wikipedia : 77 Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the... more...

Related Diseases for Capillary Leak Syndrome

Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 230)
# Related Disease Score Top Affiliating Genes
1 perinatal necrotizing enterocolitis 30.1 CXCL8 IL6
2 brucellosis 30.1 CXCL8 IL2 IL6
3 meningitis 30.0 ALB CXCL8 IL6
4 kawasaki disease 29.8 ALB ELANE IL6
5 adult respiratory distress syndrome 29.3 C4A CXCL8 ELANE IL6
6 myeloma, multiple 29.0 ALB CSF2 CXCL8 IL2 IL6
7 systemic capillary leak syndrome 12.7
8 dengue disease 11.2
9 compartment syndrome 10.4
10 influenza 10.4
11 hemorrhagic fever 10.3 ALB IL6
12 pyuria 10.3 ALB CXCL8
13 fasciitis 10.3 CXCL8 IL6
14 lymphoma 10.3
15 euthyroid sick syndrome 10.3 ALB IL6
16 noma 10.3 ALB CXCL8
17 recurrent corneal erosion 10.3 CXCL8 IL6
18 bagassosis 10.3 CXCL8 IL6
19 acute transverse myelitis 10.3 CXCL8 IL6
20 transverse myelitis 10.3 CXCL8 IL6
21 complement deficiency 10.3 C3 C4A
22 orthostatic proteinuria 10.3 ALB C3
23 denture stomatitis 10.3 CXCL8 IL6
24 papillary conjunctivitis 10.3 CXCL8 IL6
25 funisitis 10.3 CXCL8 IL6
26 psoriasis 10.3
27 proliferative glomerulonephritis 10.3 C3 IL6
28 transient arthritis 10.3 ALB IL6
29 ascending cholangitis 10.3 ALB C3
30 louse-borne relapsing fever 10.3 CXCL8 IL6
31 endometrial disease 10.3 CXCL8 IL6
32 vaginal disease 10.3 CXCL8 IL6
33 pediatric systemic lupus erythematosus 10.3 C3 C4A
34 hand, foot and mouth disease 10.3 C4A IL6
35 vaginitis 10.3 CXCL8 IL6
36 pyelitis 10.2 CXCL8 IL6
37 immunodeficiency due to a classical component pathway complement deficiency 10.2 C1S C4A
38 viral meningitis 10.2 CXCL8 IL6
39 hypersensitivity vasculitis 10.2 C3 C4A
40 prediabetes syndrome 10.2 ALB IL6
41 toxicodendron dermatitis 10.2 CXCL8 IL2
42 radiculopathy 10.2 CXCL8 IL6
43 cowpox 10.2 CXCL8 IL6
44 bacteriuria 10.2 CXCL8 IL6
45 pure red-cell aplasia 10.2 ALB IL2
46 trichomoniasis 10.2 CXCL8 IL2
47 clonorchiasis 10.2 CXCL8 IL2
48 pulpitis 10.2 CXCL8 IL6
49 retinitis pigmentosa 44 10.2 CXCL8 IL2
50 crohn's colitis 10.2 CXCL8 IL2

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 ALB CSF2 ELANE IL2 IL6

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 95)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3 Anti-Bacterial Agents Phase 4,Phase 2
4 Anti-Infective Agents Phase 4,Phase 3,Phase 2
5 Antibiotics, Antitubercular Phase 4,Phase 2
6 Antitubercular Agents Phase 4,Phase 2
7 Amoxicillin-Potassium Clavulanate Combination Phase 4
8 beta-Lactamase Inhibitors Phase 4
9
Aldesleukin Approved Phase 3,Phase 2,Phase 1 85898-30-2, 110942-02-4
10
Sargramostim Approved, Investigational Phase 3,Phase 2,Phase 1 123774-72-1, 83869-56-1
11
Isotretinoin Approved Phase 3,Phase 2 4759-48-2 5538 5282379
12
Codeine Approved, Illicit Phase 3 76-57-3 5284371
13
Dopamine Approved Phase 3 62-31-7, 51-61-6 681
14
Ondansetron Approved Phase 3 99614-02-5 4595
15
Acetaminophen Approved Phase 3 103-90-2 1983
16
Ibuprofen Approved Phase 3 15687-27-1 3672
17
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
18
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
19
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538 444795
20
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
21
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
22 Analgesics Phase 3,Phase 2
23 Anti-Retroviral Agents Phase 3,Phase 2
24 Keratolytic Agents Phase 3,Phase 2
25 Antibodies Phase 3,Phase 2,Phase 1
26 Immunologic Factors Phase 3,Phase 2,Phase 1
27 Dermatologic Agents Phase 3,Phase 2
28 Interleukin-2 Phase 3,Phase 2,Phase 1
29 Analgesics, Non-Narcotic Phase 3,Phase 2
30 Anti-HIV Agents Phase 3,Phase 2
31 Ch14.18 monoclonal antibody Phase 3,Phase 2
32 retinol Phase 3
33 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Immunological Phase 3
35 Vitamins Phase 3
36 Antiviral Agents Phase 3,Phase 2
37 Retinol palmitate Phase 3
38 Peripheral Nervous System Agents Phase 3,Phase 2
39 Immunoglobulins Phase 3,Phase 2,Phase 1
40 Dopamine Agents Phase 3
41 Central Nervous System Depressants Phase 3
42 Dopamine D2 Receptor Antagonists Phase 3
43 Anti-Inflammatory Agents Phase 3
44 Analgesics, Opioid Phase 3
45 Narcotics Phase 3
46 Serotonin Agents Phase 3
47 Serotonin Antagonists Phase 3
48 Anti-Inflammatory Agents, Non-Steroidal Phase 3
49 Antipyretics Phase 3
50 Neurotransmitter Agents Phase 3

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite Recruiting NCT02570347 Phase 4 Co-amoxiclav
2 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed NCT01041638 Phase 3 Isotretinoin
3 Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy Terminated NCT00147355 Phase 3 ondansetron, ibuprofen, paracetamol;Ondansetron, ibuprofen, paracetamol;metoclopramide, ibuprofen, paracetamol;Metoclopramide, codeine phosphate, ibuprofen, paracetamol
4 Safety Study of CAT-8015 to Treat Advanced B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia (NHL or CLL) Completed NCT01030536 Phase 1, Phase 2 CAT-8015 20 mcg/kg;CAT-8015 30 mcg/kg;CAT-8015 40 mcg/kg;CAT-8015 50 mcg/kg;CAT-8015 60 mcg/kg
5 A Study Of The Safety And Effects Of One Or More Doses Of HSP-130 Injected Under The Skin In Women With Breast Cancer That Has Not Spread To Distant Sites In The Body. Completed NCT02650193 Phase 2 HSP-130
6 Mesenchymal Stromal Cells in Living Donor Kidney Transplantation Recruiting NCT03478215 Phase 2
7 NB2013-HR German (GPOH) / Dutch (DCOG) Trial Terminated NCT02641782 Phase 2 antibody ch14.18;GM-CSF;IL-2 i.v.;IL-2 s.c.;Retinoic acid
8 Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic Leukemia and Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT02338050 Phase 2
9 CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploid Donor Natural Killer Cell Treatment in Older AML in First Complete Remission Withdrawn NCT01639456 Phase 2 Cyclophosphamide;Fludarabine;Aldesleukin
10 DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma Completed NCT00889408 Phase 1
11 Combination Chemotherapy, Monoclonal Antibody, and Natural Killer Cells in Treating Young Patients With Recurrent or Refractory Neuroblastoma Completed NCT01576692 Phase 1 Chemotherapy
12 CAT-8015 in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma Completed NCT00659425 Phase 1 CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox)
13 Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions Completed NCT00660166 Phase 1
14 Monitoring the IMmUological TOXicity of Drugs Completed NCT03480529 drug inducing arthritis, lupus, hepatitis, or capillary leak syndrom
15 Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients Completed NCT03410771 Monitor antibiotic exposure (PK profile)
16 Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia Completed NCT00167167 Not Applicable
17 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
18 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
19 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Recruiting NCT02965339
20 Observational Study of Blinatumomab Recruiting NCT03117621
21 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Active, not recruiting NCT02853682

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

42
Endothelial, Breast, Skin, Kidney, B Cells, Bone, Bone Marrow

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 272)
# Title Authors Year
1
Clinical communication: systemic capillary leak syndrome due to mast cell activation? ( 30639435 )
2019
2
Myocardial oedema in an 8-year-old Chinese boy with Idiopathic systemic capillary leak syndrome. ( 30665393 )
2019
3
Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis. ( 30691103 )
2019
4
First experience with Tolvaptan for the treatment of neonates and infants with capillary leak syndrome after cardiac surgery. ( 30755181 )
2019
5
Chemotherapy-induced skin toxicity and capillary leak syndrome. ( 30847892 )
2019
6
Capillary leak-syndrome triggered by Maripa virus in French Guiana: case report and implication for pathogenesis. ( 30876401 )
2019
7
The Role of Failing Autonomic Nervous System on Life-Threatening Idiopathic Systemic Capillary Leak Syndrome. ( 29732372 )
2018
8
Capillary Leak Syndrome Aggravated by Influenza Type A Infection. ( 29974010 )
2018
9
Intravenous immunoglobulin therapy for dengue capillary leak syndrome in a renal allograft recipient. ( 29925559 )
2018
10
Recognition and management of idiopathic systemic capillary leak syndrome: an evidence-based review. ( 29564922 )
2018
11
Idiopathic systemic capillary leak syndrome (Clarkson syndrome) in childhood: systematic literature review. ( 29936591 )
2018
12
Capillary leak syndrome as a complication of antibody-mediated rejection treatment: a case report. ( 29344912 )
2018
13
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease). ( 29360169 )
2018
14
Idiopathic Systemic Capillary Leak Syndrome. ( 29910550 )
2018
15
A Viral Polymyositis Masquerade: Life-Threatening Case of Juvenile Dermatomyositis Complicated by Systemic Capillary Leak Syndrome. ( 29720802 )
2018
16
Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report. ( 29779703 )
2018
17
Raised Serum Levels of Syndecan-1 (CD138), in a Case of Acute Idiopathic Systemic Capillary Leak Syndrome (SCLS) (Clarkson's Disease). ( 29449526 )
2018
18
Capillary leak syndrome and aseptic meningitis in a patient with Kawasaki disease: A case report. ( 29879013 )
2018
19
Myocardial dysfunction is frequent in systemic capillary-leak syndrome (Clarkson disease) severe episodes. ( 29477581 )
2018
20
Capillary leak syndrome in Daboia russelii bite-a complication associated with poor outcome. ( 29584906 )
2018
21
Anesthetic Considerations for a Patient With Chronic Systemic Capillary Leak Syndrome: A Case Report. ( 29894349 )
2018
22
Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection. ( 30158273 )
2018
23
Sjögren's syndrome concurrent with protein-losing gastroenteropathy with secondary systemic capillary leak syndrome : A case report. ( 30214773 )
2018
24
Correction: Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection. ( 30287629 )
2018
25
Probable Mechanisms Involved in Immunotoxin Mediated Capillary Leak Syndrome (CLS) and Recently Developed Countering Strategies. ( 30289072 )
2018
26
Whole Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome. ( 30289850 )
2018
27
Systemic Capillary Leak Syndrome (Clarkson Syndrome) in Cancer Patients: A Systematic Review. ( 30404164 )
2018
28
Chronic systemic capillary leak syndrome treatment with intravenous immune globulin: Case report and review of the literature
. ( 30431430 )
2018
29
How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis? ( 29364440 )
2017
30
Capillary Leak Syndrome Following Snakebite Envenomation. ( 29142382 )
2017
31
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. ( 28182327 )
2017
32
Clinical Presentation, Management, and Prognostic Factors of Idiopathic Systemic Capillary Leak Syndrome: A Systematic Review. ( 28939140 )
2017
33
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome. ( 29097442 )
2017
34
The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission. ( 28622216 )
2017
35
Capillary leak syndrome: etiologies, pathophysiology, and management. ( 28318633 )
2017
36
Life-threatening systemic capillary leak syndrome in juvenile dermatomyositis. ( 28957546 )
2017
37
Capillary leak syndrome in neuromyelitis optica treated with rituximab. ( 28755680 )
2017
38
Mimicker of hereditary angioedema: Idiopathic systemic capillary leak syndrome successfully treated with intravenous immunoglobulin. ( 28377172 )
2017
39
Gemcitabine-induced chronic systemic capillary leak syndrome. ( 28855215 )
2017
40
Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. ( 28602874 )
2017
41
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. ( 28122158 )
2017
42
Distributive Shock in the Emergency Department: Sepsis, Anaphylaxis, or Capillary Leak Syndrome? ( 28238385 )
2017
43
Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study. ( 27734564 )
2016
44
Severe cerebral involvement due to idiopathic systemic capillary leak syndrome. ( 27099745 )
2016
45
Idiopathic systemic capillary leak syndrome (Clarkson disease). ( 28012935 )
2016
46
Subcutaneous Immunoglobulin Therapy Prevents Systemic Capillary Leak Syndrome Attack. ( 27059380 )
2016
47
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate. ( 27338086 )
2016
48
Sudden cardiac arrest in a 73-year-old woman caused by systemic capillary leak syndrome. ( 27056382 )
2016
49
Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. ( 27622772 )
2016
50
Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. ( 27386947 )
2016

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 C1S C3 C4A CSF2 CXCL8 ELANE
2
Show member pathways
12.99 C3 CXCL8 IL2 IL6
3
Show member pathways
12.77 C3 CSF2 CXCL8 IL6
4
Show member pathways
12.61 C3 C4A CXCL8 IL2 IL6
5
Show member pathways
12.42 C3 CXCL8 IL2 IL6
6
Show member pathways
12.26 CSF2 IL2 IL6
7 12.19 CSF2 IL2 IL6
8
Show member pathways
12.17 ALB IL2 IL6
9
Show member pathways
12.16 CSF2 CXCL8 IL6
10 12.03 C4A CXCL8 IL6
11
Show member pathways
11.97 C1S C3 C4A
12 11.94 C1S C3 C4A
13
Show member pathways
11.92 C1S C3 C4A
14
Show member pathways
11.89 C1S CSF2 IL6
15 11.89 CSF2 CXCL8 ELANE IL6
16 11.86 CXCL8 IL2 IL6
17 11.84 CSF2 IL2 IL6
18
Show member pathways
11.79 C1S C3 C4A
19 11.74 CSF2 CXCL8 IL6
20
Show member pathways
11.72 CSF2 CXCL8 IL6
21 11.7 CSF2 CXCL8 IL6
22 11.67 CSF2 CXCL8 IL6
23
Show member pathways
11.59 CSF2 CXCL8 IL2
24 11.57 CSF2 IL2 IL6
25 11.54 CSF2 IL2 IL6
26 11.47 CSF2 CXCL8 IL6
27 11.47 C1S C3 C4A
28 11.37 CSF2 CXCL8 IL2 IL6
29 11.35 C3 CXCL8 IL6
30 11.27 CSF2 CXCL8 IL6
31 11.19 CXCL8 IL6
32 11.18 CSF2 CXCL8
33
Show member pathways
11.06 CSF2 CXCL8 IL2 IL6
34 10.92 CXCL8 IL6
35 10.9 CSF2 CXCL8 IL2 IL6
36 10.9 CSF2 IL2 IL6
37 10.9 C1S C3 C4A CXCL8 IL6
38 10.85 CSF2 CXCL8 IL2 IL6

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ALB C1S C3 C4A CSF2 CXCL8
2 endoplasmic reticulum lumen GO:0005788 9.56 ALB C3 C4A IL6
3 blood microparticle GO:0072562 9.46 ALB C1S C3 C4A
4 extracellular space GO:0005615 9.28 ALB C1S C3 C4A CSF2 CXCL8

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 C1S C3 C4A ELANE
2 regulation of signaling receptor activity GO:0010469 9.81 CSF2 CXCL8 IL2 IL6
3 inflammatory response GO:0006954 9.76 C3 C4A CXCL8 IL6
4 cellular response to lipopolysaccharide GO:0071222 9.71 CSF2 CXCL8 IL6
5 post-translational protein modification GO:0043687 9.71 ALB C3 C4A IL6
6 complement activation, classical pathway GO:0006958 9.7 C1S C3 C4A
7 cytokine-mediated signaling pathway GO:0019221 9.67 CSF2 CXCL8 IL2 IL6
8 regulation of complement activation GO:0030449 9.65 C1S C3 C4A
9 complement activation GO:0006956 9.61 C1S C3 C4A
10 positive regulation of immunoglobulin secretion GO:0051024 9.49 IL2 IL6
11 cellular protein metabolic process GO:0044267 9.46 ALB C3 C4A IL6
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 CSF2 IL2 IL6
13 positive regulation of apoptotic cell clearance GO:2000427 9.32 C3 C4A
14 immune response GO:0006955 9.02 C3 CSF2 CXCL8 IL2 IL6
15 negative regulation of chemokine biosynthetic process GO:0045079 8.96 ELANE IL6

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 CSF2 IL2 IL6
2 endopeptidase inhibitor activity GO:0004866 9.26 C3 C4A
3 serine-type endopeptidase activity GO:0004252 9.26 C1S C3 C4A ELANE
4 cytokine activity GO:0005125 8.92 CSF2 CXCL8 IL2 IL6

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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