MCID: CPL003
MIFTS: 45

Capillary Leak Syndrome

Categories: Cardiovascular diseases, Rare diseases, Bone diseases

Aliases & Classifications for Capillary Leak Syndrome

MalaCards integrated aliases for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 55 44 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:14400
MeSH 44 D019559
NCIt 50 C62578
SNOMED-CT 68 87730004
UMLS 73 C0343084

Summaries for Capillary Leak Syndrome

MalaCards based summary : Capillary Leak Syndrome is related to perinatal necrotizing enterocolitis and kawasaki disease. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Amoxicillin and Clavulanic Acid have been mentioned in the context of this disorder. Affiliated tissues include endothelial, b cells and kidney, and related phenotype is neoplasm.

Wikipedia : 76 Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the... more...

Related Diseases for Capillary Leak Syndrome

Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 226)
# Related Disease Score Top Affiliating Genes
1 perinatal necrotizing enterocolitis 30.2 CXCL8 IL6
2 kawasaki disease 29.9 ALB ELANE IL6
3 peritonitis 29.8 ALB CXCL8 IL6
4 meningitis 29.8 ALB CXCL8 IL6
5 brucellosis 29.8 CXCL8 IL2 IL6
6 adult respiratory distress syndrome 28.9 C4A CXCL8 ELANE IL6
7 myeloma, multiple 27.5 ALB CSF2 CXCL8 IL2 IL6
8 systemic capillary leak syndrome 12.7
9 dengue disease 11.0
10 pyuria 10.6 ALB CXCL8
11 noma 10.6 ALB CXCL8
12 euthyroid sick syndrome 10.6 ALB IL6
13 transient arthritis 10.6 ALB IL6
14 recurrent corneal erosion 10.5 CXCL8 IL6
15 bagassosis 10.5 CXCL8 IL6
16 acute transverse myelitis 10.5 CXCL8 IL6
17 hemorrhagic fever 10.5 ALB IL6
18 pasteurellosis 10.5 ALB ELANE
19 denture stomatitis 10.5 CXCL8 IL6
20 hand, foot and mouth disease 10.5 C4A IL6
21 papillary conjunctivitis 10.5 CXCL8 IL6
22 funisitis 10.5 CXCL8 IL6
23 prediabetes syndrome 10.5 ALB IL6
24 hydrarthrosis 10.5 C4A IL6
25 vaginal disease 10.5 CXCL8 IL6
26 louse-borne relapsing fever 10.5 CXCL8 IL6
27 preterm premature rupture of the membranes 10.5 CXCL8 IL6
28 endometrial disease 10.5 CXCL8 IL6
29 transverse myelitis 10.5 CXCL8 IL6
30 vaginitis 10.5 CXCL8 IL6
31 toxicodendron dermatitis 10.5 CXCL8 IL2
32 pure red-cell aplasia 10.5 ALB IL2
33 bacteriuria 10.4 CXCL8 IL6
34 hemorrhagic fever with renal syndrome 10.4 ALB IL6
35 radiculopathy 10.4 CXCL8 IL6
36 membranoproliferative glomerulonephritis 10.4 ALB C4A
37 protein-energy malnutrition 10.4 ALB IL6
38 cowpox 10.4 CXCL8 IL6
39 trichomoniasis 10.4 CXCL8 IL2
40 cytomegalovirus infection 10.4 CXCL8 IL6
41 meningoencephalitis 10.4 ALB IL6
42 pulpitis 10.4 CXCL8 IL6
43 clonorchiasis 10.4 CXCL8 IL2
44 cardiac rupture 10.4 CXCL8 ELANE
45 crohn's colitis 10.4 CXCL8 IL2
46 status asthmaticus 10.4 CXCL8 ELANE
47 keratoconjunctivitis sicca 10.4 ALB IL6
48 fasciitis 10.4 CXCL8 IL6
49 extramedullary plasmacytoma 10.4 IL2 IL6
50 immunodeficiency due to a classical component pathway complement deficiency 10.4 C1S C4A

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CSF2 ELANE IL2 IL6 ALB

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 83)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2 Clavulanic Acid Phase 4
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4,Phase 3,Phase 2
6 Antitubercular Agents Phase 4
7 Amoxicillin-Potassium Clavulanate Combination Phase 4
8 beta-Lactamase Inhibitors Phase 4
9
Isotretinoin Approved Phase 3,Phase 2 4759-48-2 5538 5282379
10
Aldesleukin Approved Phase 3,Phase 2,Phase 1 85898-30-2, 110942-02-4
11
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
12
Acetaminophen Approved Phase 3 103-90-2 1983
13
Ibuprofen Approved Phase 3 15687-27-1 3672
14
Metoclopramide Approved, Investigational Phase 3 364-62-5 4168
15
Codeine Approved, Illicit Phase 3 76-57-3 5284371
16
Ondansetron Approved Phase 3 99614-02-5 4595
17
Guaifenesin Approved, Investigational, Vet_approved Phase 3 93-14-1 3516
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354
19
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
20
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 2 302-79-4 5538 444795
21 Interleukin-2 Phase 3,Phase 2,Phase 1
22 Analgesics Phase 3,Phase 2
23 Retinol palmitate Phase 3
24 Analgesics, Non-Narcotic Phase 3,Phase 2
25 Dermatologic Agents Phase 3,Phase 2
26 Peripheral Nervous System Agents Phase 3,Phase 2
27 Vitamins Phase 3
28 Antibodies Phase 3,Phase 2,Phase 1
29 Immunoglobulins Phase 3,Phase 2,Phase 1
30 Antibodies, Monoclonal Phase 3,Phase 1
31 Anti-HIV Agents Phase 3,Phase 2
32 Keratolytic Agents Phase 3,Phase 2
33 Anti-Retroviral Agents Phase 3,Phase 2
34 Antiviral Agents Phase 3,Phase 2
35 Respiratory System Agents Phase 3
36 Central Nervous System Depressants Phase 3
37 Chlorpheniramine, phenylpropanolamine drug combination Phase 3
38 Serotonin Agents Phase 3
39 Serotonin Antagonists Phase 3
40 Gastrointestinal Agents Phase 3
41 Narcotics Phase 3
42 Neurotransmitter Agents Phase 3
43 Cyclooxygenase Inhibitors Phase 3
44 Analgesics, Opioid Phase 3
45 Tranquilizing Agents Phase 3
46 Anti-Anxiety Agents Phase 3
47 Dopamine Agents Phase 3
48 Dopamine Antagonists Phase 3
49 Dopamine D2 Receptor Antagonists Phase 3
50 Antiemetics Phase 3

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Routine Antibiotic vs. Directed Antibiotic Treatment in Snake Bite Recruiting NCT02570347 Phase 4 Co-amoxiclav
2 Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma Completed NCT01041638 Phase 3 Isotretinoin
3 Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy Terminated NCT00147355 Phase 3 ondansetron, ibuprofen, paracetamol;Ondansetron, ibuprofen, paracetamol;metoclopramide, ibuprofen, paracetamol;Metoclopramide, codeine phosphate, ibuprofen, paracetamol
4 Safety Study of CAT-8015 to Treat Advanced B-cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia (NHL or CLL) Completed NCT01030536 Phase 1, Phase 2 CAT-8015 20 mcg/kg;CAT-8015 30 mcg/kg;CAT-8015 40 mcg/kg;CAT-8015 50 mcg/kg;CAT-8015 60 mcg/kg
5 Mesenchymal Stromal Cells in Living Donor Kidney Transplantation Recruiting NCT03478215 Phase 2 Tacrolimus;Mycophenolate Mofetil;Basiliximab
6 NB2013-HR German (GPOH) / Dutch (DCOG) Trial Terminated NCT02641782 Phase 2 antibody ch14.18;GM-CSF;IL-2 i.v.;IL-2 s.c.;Retinoic acid
7 Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic Leukemia and Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT02338050 Phase 2
8 CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploid Donor Natural Killer Cell Treatment in Older AML in First Complete Remission Withdrawn NCT01639456 Phase 2 Cyclophosphamide;Fludarabine;Aldesleukin
9 DT2219ARL for Relapsed or Refractory CD19 (+), CD 22 (+) B-Lineage Leukemia Or Lymphoma Completed NCT00889408 Phase 1
10 CAT-8015 in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma Completed NCT00659425 Phase 1 CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox);CAT-8015 (Moxetumomab Pasudotox)
11 Human Leukocyte Antigen (HLA) Class I Haplotype Mismatched Natural Killer Cell Infusions Completed NCT00660166 Phase 1
12 Combination Chemotherapy, Monoclonal Antibody, and Natural Killer Cells in Treating Young Patients With Recurrent or Refractory Neuroblastoma Active, not recruiting NCT01576692 Phase 1 Chemotherapy
13 Monitoring the IMmUological TOXicity of Drugs Completed NCT03480529 drug inducing arthritis, lupus or capillary leak syndrom
14 Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients Completed NCT03410771 Monitor antibiotic exposure (PK profile)
15 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Completed NCT03135496
16 Donor Lymphocyte Infusion (DLI) for Relapsed (Post Transplant) Leukemia Completed NCT00167167 Not Applicable
17 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
18 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Recruiting NCT02853682
19 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Recruiting NCT02965339
20 Observational Study of Blinatumomab Recruiting NCT03117621

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

41
Endothelial, B Cells, Kidney, Bone Marrow, Bone, T Cells, Lung

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 256)
# Title Authors Year
1
The Role of Failing Autonomic Nervous System on Life-Threatening Idiopathic Systemic Capillary Leak Syndrome. ( 29732372 )
2018
2
Capillary Leak Syndrome Aggravated by Influenza Type A Infection. ( 29974010 )
2018
3
Intravenous immunoglobulin therapy for dengue capillary leak syndrome in a renal allograft recipient. ( 29925559 )
2018
4
Recognition and management of idiopathic systemic capillary leak syndrome: an evidence-based review. ( 29564922 )
2018
5
Idiopathic systemic capillary leak syndrome (Clarkson syndrome) in childhood: systematic literature review. ( 29936591 )
2018
6
Capillary leak syndrome as a complication of antibody-mediated rejection treatment: a case report. ( 29344912 )
2018
7
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease). ( 29360169 )
2018
8
Idiopathic Systemic Capillary Leak Syndrome. ( 29910550 )
2018
9
A Viral Polymyositis Masquerade: Life-Threatening Case of Juvenile Dermatomyositis Complicated by Systemic Capillary Leak Syndrome. ( 29720802 )
2018
10
Idiopathic systemic capillary leak syndrome presenting as septic shock: A case report. ( 29779703 )
2018
11
Raised Serum Levels of Syndecan-1 (CD138), in a Case of Acute Idiopathic Systemic Capillary Leak Syndrome (SCLS) (Clarkson's Disease). ( 29449526 )
2018
12
Capillary leak syndrome and aseptic meningitis in a patient with Kawasaki disease: A case report. ( 29879013 )
2018
13
Myocardial dysfunction is frequent in systemic capillary-leak syndrome (Clarkson disease) severe episodes. ( 29477581 )
2018
14
Capillary leak syndrome in Daboia russelii bite-a complication associated with poor outcome. ( 29584906 )
2018
15
Anesthetic Considerations for a Patient With Chronic Systemic Capillary Leak Syndrome: A Case Report. ( 29894349 )
2018
16
How relevant are vascular endothelial growth factor and intercellular adhesion molecule in the systemic capillary leak syndrome of psoriasis? ( 29364440 )
2017
17
Capillary Leak Syndrome Following Snakebite Envenomation. ( 29142382 )
2017
18
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: reply. ( 28182327 )
2017
19
Clinical Presentation, Management, and Prognostic Factors of Idiopathic Systemic Capillary Leak Syndrome: A Systematic Review. ( 28939140 )
2017
20
A p190BRhoGAP mutation and prolonged RhoB activation in fatal systemic capillary leak syndrome. ( 29097442 )
2017
21
The Clinical Picture of Severe Systemic Capillary-Leak Syndrome Episodes Requiring ICU Admission. ( 28622216 )
2017
22
Capillary leak syndrome: etiologies, pathophysiology, and management. ( 28318633 )
2017
23
Life-threatening systemic capillary leak syndrome in juvenile dermatomyositis. ( 28957546 )
2017
24
Capillary leak syndrome in neuromyelitis optica treated with rituximab. ( 28755680 )
2017
25
Mimicker of hereditary angioedema: Idiopathic systemic capillary leak syndrome successfully treated with intravenous immunoglobulin. ( 28377172 )
2017
26
Gemcitabine-induced chronic systemic capillary leak syndrome. ( 28855215 )
2017
27
Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. ( 28602874 )
2017
28
Microangiopathic hemolytic anemia due to ADAMTS-13 loss in idiopathic systemic capillary leak syndrome: comment. ( 28122158 )
2017
29
Distributive Shock in the Emergency Department: Sepsis, Anaphylaxis, or Capillary Leak Syndrome? ( 28238385 )
2017
30
Epidemiology, risk factors, and prognosis of capillary leak syndrome in pediatric recipients of stem cell transplants: a retrospective single-center cohort study. ( 27734564 )
2016
31
Severe cerebral involvement due to idiopathic systemic capillary leak syndrome. ( 27099745 )
2016
32
Idiopathic systemic capillary leak syndrome (Clarkson disease). ( 28012935 )
2016
33
Subcutaneous Immunoglobulin Therapy Prevents Systemic Capillary Leak Syndrome Attack. ( 27059380 )
2016
34
Fulminant capillary leak syndrome in a patient with systemic sclerosis treated with imatinib mesylate. ( 27338086 )
2016
35
Sudden cardiac arrest in a 73-year-old woman caused by systemic capillary leak syndrome. ( 27056382 )
2016
36
Microangiopathic Hemolytic Anemia Due to ADAMTS-13 Loss in Idiopathic Systemic Capillary Leak Syndrome. ( 27622772 )
2016
37
Isoform D of vascular endothelial growth factor in systemic capillary leak syndrome: a case report. ( 27386947 )
2016
38
A Systemic Capillary Leak Syndrome (Clarkson Syndrome) in a Patient with Chronic Lymphocytic Leukemia: A Case Report in an Out-of-Hospital Setting. ( 27069700 )
2016
39
Compartment Syndrome as a Result of Systemic Capillary Leak Syndrome. ( 27688917 )
2016
40
Rhabdomyolysis and capillary leak syndrome in a patient treated with topical imiquimod. ( 27061736 )
2016
41
Scrub typhus presenting as capillary leak syndrome. ( 27728427 )
2016
42
Systemic capillary leak syndrome and autoimmune diseases: A case series. ( 27637319 )
2016
43
Fatal Primary Capillary Leak Syndrome in a Late Preterm Newborn. ( 27142601 )
2016
44
Idiopathic Systemic Capillary Leak Syndrome: A Case Report. ( 27195144 )
2016
45
A Case of Refractory Systemic Capillary Leak Syndrome (Clarkson's Disease) during Pregnancy. ( 28003676 )
2016
46
1197: ACUTE THERAPY WITH IVIG IN A PEDIATRIC PATIENT WITH IDIOPATHIC SYSTEMIC CAPILLARY LEAK SYNDROME. ( 26570858 )
2015
47
A fatal case of acute progression of generalized edema and simultaneous flash pulmonary edema in a patient with idiopathic systemic capillary leak syndrome: a case report. ( 25928289 )
2015
48
A case report of idiopathic systemic capillary leak syndrome that occurred during the postoperative period of abdominoperineal resection for colorectal cancer. ( 25594640 )
2015
49
An uncommon cause of distributive shock: Lessons from two consecutive cases of idiopathic systemic capillary leak syndrome (Clarkson's disease). ( 26300309 )
2015
50
Clinical and pathological findings of a fatal systemic capillary leak syndrome (Clarkson disease): a case report. ( 25738482 )
2015

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 C1S C4A CSF2 CXCL8 ELANE IL2
2
Show member pathways
12.63 C4A CXCL8 IL2 IL6
3
Show member pathways
12.35 CSF2 CXCL8 IL6
4
Show member pathways
12.33 CSF2 CXCL8 IL2 IL6
5
Show member pathways
12.21 CSF2 IL2 IL6
6 12.21 CSF2 IL2 IL6
7
Show member pathways
12.11 ALB IL2 IL6
8
Show member pathways
12.11 CSF2 CXCL8 IL6
9 11.96 C4A CXCL8 IL6
10 11.89 CSF2 CXCL8 ELANE IL6
11 11.81 CXCL8 IL2 IL6
12 11.79 CSF2 IL2 IL6
13 11.69 CSF2 CXCL8 IL6
14
Show member pathways
11.67 CSF2 CXCL8 IL6
15 11.64 CSF2 CXCL8 IL6
16 11.61 CSF2 CXCL8 IL6
17
Show member pathways
11.53 CSF2 CXCL8 IL2
18 11.5 CSF2 IL2 IL6
19 11.38 CSF2 CXCL8 IL6
20 11.37 CSF2 CXCL8 IL2 IL6
21 11.36 CXCL8 IL6
22 11.36 IL2 IL6
23 11.34 CXCL8 IL6
24 11.32 ELANE IL6
25 11.32 CSF2 IL6
26 11.3 CXCL8 IL6
27 11.23 CSF2 CXCL8 IL6
28 11.15 CXCL8 IL6
29 11.14 C1S C4A CXCL8 IL6
30 11.13 CSF2 CXCL8
31 10.91 CSF2 IL2 IL6
32 10.85 CXCL8 IL6
33
Show member pathways
10.72 CSF2 CXCL8 IL2 IL6

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ALB C1S C4A CSF2 CXCL8 ELANE
2 endoplasmic reticulum lumen GO:0005788 9.43 ALB C4A IL6
3 blood microparticle GO:0072562 9.33 ALB C1S C4A
4 extracellular space GO:0005615 9.23 ALB C1S C4A CSF2 CXCL8 ELANE

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.71 CSF2 CXCL8 IL2 IL6
2 cellular protein metabolic process GO:0044267 9.63 ALB C4A IL6
3 regulation of signaling receptor activity GO:0010469 9.62 CSF2 CXCL8 IL2 IL6
4 cellular response to lipopolysaccharide GO:0071222 9.54 CSF2 CXCL8 IL6
5 cytokine-mediated signaling pathway GO:0019221 9.46 CSF2 CXCL8 IL2 IL6
6 positive regulation of leukocyte chemotaxis GO:0002690 9.43 CXCL8 IL6
7 positive regulation of immunoglobulin secretion GO:0051024 9.26 IL2 IL6
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 CSF2 IL2 IL6
9 negative regulation of chemokine biosynthetic process GO:0045079 8.62 ELANE IL6

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.33 C1S C4A ELANE
2 growth factor activity GO:0008083 9.13 CSF2 IL2 IL6
3 cytokine activity GO:0005125 8.92 CSF2 CXCL8 IL2 IL6

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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