SCLS
MCID: CPL003
MIFTS: 56

Capillary Leak Syndrome (SCLS)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Capillary Leak Syndrome

MalaCards integrated aliases for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 52 58 54 43 15 17 71
Systemic Capillary Leak Syndrome 52 58 17
Clarkson Disease 52 58
Scls 52 58
Capillary Leak Syndrome with Monoclonal Gammopathy 52
Periodic Systemic Capillary Leak Syndrome 52
Capillary Hyperpermeability Syndrome 58
Idiopathic Capillary Leak Syndrome 58

Characteristics:

Orphanet epidemiological data:

58
systemic capillary leak syndrome
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: adult;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases


Summaries for Capillary Leak Syndrome

NIH Rare Diseases : 52 Systemic capillary leak syndrome (SCLS) is a condition in which fluid and proteins leak out of tiny blood vessels, into surrounding tissues . This can result in dangerously low blood pressure (hypotensison), hypoalbuminemia , and a decrease in plasma volume (hemoconcentration ). Initial symptoms may include fatigue, nausea, abdominal pain, extreme thirst, and sudden increase in body weight. Episodes of SCLS vary in frequency, with some people having one episode in their lifetime, and others having several per year. The severity also varies, and the condition can be fatal. In many cases the cause is not known (idiopathic SCLS). Some people with SCLS report having had an infection (such as a virus ) before the episode. Some cases of capillary leak are associated with various conditions of the heart, kidney, or liver. Treatment during an episode may involve stabilizing the airway and breathing, and infusion of fluids, medications, or blood products. Periodic infusions or the use of certain medications may be used to prevent future episodes.

MalaCards based summary : Capillary Leak Syndrome, also known as systemic capillary leak syndrome, is related to dengue disease and hydrops, lactic acidosis, and sideroblastic anemia. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Pathways in cancer. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include endothelial, liver and kidney, and related phenotypes are leukocytosis and pedal edema

Wikipedia : 74 Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the... more...

Related Diseases for Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 dengue disease 32.0 ICOSLG CD8A ALB
2 hydrops, lactic acidosis, and sideroblastic anemia 31.1 SERPING1 C1S ALB
3 cardiogenic shock 31.0 IL6 ADM
4 myositis 31.0 IL6 IL2 ICOSLG CXCL8
5 interstitial lung disease 30.9 IL6 CXCL8 CSF2 ALB
6 fasciitis 30.7 IL6 IL2 CXCL8
7 toxic shock syndrome 30.6 IL6 IL2 EDNRA CXCL8 C1S
8 pericarditis 30.6 IL6 CXCL8 ALB
9 brucellosis 30.5 IL6 IL2 CXCL8
10 kawasaki disease 30.5 IL6 ELANE ALB ADM
11 angioedema 30.3 SERPING1 IL6 C4A C3 C1S
12 necrotizing fasciitis 30.2 IL6 IL2 CXCL8 ALB
13 endocarditis 30.2 IL6 CXCL8 ALB
14 acquired angioedema 30.2 SERPING1 C3 C1S
15 acute pancreatitis 30.1 IL6 ELANE CXCL8 ALB
16 respiratory failure 30.1 IL6 ELANE CXCL8 ALB ADM
17 childhood type dermatomyositis 30.1 IL6 ICOSLG CD8A
18 neutropenia 30.1 IL6 ELANE CSF3 CSF2
19 engraftment syndrome 30.0 CXCL8 CSF3 CSF2
20 neutrophilia, hereditary 30.0 IL6 CSF3 CSF2
21 vasculitis 30.0 IL6 ELANE C3 C1S
22 hypersplenism 30.0 CSF3 CSF2 ALB
23 hemolytic uremic syndrome, atypical 1 30.0 SERPING1 C4A C3 C1S
24 hereditary angioedema 29.9 SERPING1 C4A C1S ADM
25 glomerulonephritis 29.8 ELANE C4A C3 C1S ALB
26 cellulitis 29.8 IL6 ICOSLG CD8A
27 diarrhea 29.8 IL6 IL2 CXCL8 CSF3 C3 ALB
28 allergic hypersensitivity disease 29.8 IL2 ICOSLG CXCL8 CSF2
29 pulmonary hypertension 29.8 IL6 ELANE EDNRA CXCL8 ALB ADM
30 rhinitis 29.8 IL6 ICOSLG CXCL8 CSF2 ALB
31 lymphoma, hodgkin, classic 29.8 IL2 ICOSLG CSF3 CSF2
32 connective tissue disease 29.7 IL6 IL2 ICOSLG EDNRA CXCL8 CD8A
33 pneumocystosis 29.7 IL6 CSF3 CD8A ALB
34 pancreatic adenocarcinoma 29.6 IL6 IL2 CXCL8 CSF3 ALB
35 monoclonal gammopathy of uncertain significance 29.6 IL6 ICOSLG CD19
36 adult respiratory distress syndrome 29.6 IL6 ELANE CXCL8 CSF3 C4A
37 cerebral palsy 29.5 IL6 CXCL8 CSF3
38 thrombocytopenia 29.4 IL6 IL2 CXCL8 CSF3 CSF2 C3
39 thymoma 29.3 IL6 IL2 CSF3 CD8A
40 agammaglobulinemia 29.2 IL6 ICOSLG CD19
41 acute promyelocytic leukemia 29.2 IL6 ELANE CXCL8 CSF3 CSF2
42 deficiency anemia 29.2 IL6 CSF3 CSF2 CD19 ALB
43 aspergillosis 29.1 IL6 IL15 ELANE CXCL8 CSF3 CSF2
44 kidney cancer 29.1 IL2 CXCL8 CSF2 ALB
45 meningitis 29.1 IL6 IL2 CXCL8 CSF3 CSF2 C3
46 peripheral nervous system disease 29.0 IL6 IL2 ICOSLG CXCL8 CSF3 CD8A
47 autoimmune disease 28.6 IL6 IL2 IL15 ICOSLG CXCL8 CSF2
48 lung disease 28.6 IL6 IL15 ELANE CXCL8 CSF3 CSF2
49 leukemia, chronic myeloid 28.4 ELANE CSF3 CSF2 CD8A CD19
50 skin disease 28.4 SERPING1 IL6 IL2 ICOSLG CXCL8 CSF2

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

Human phenotypes related to Capillary Leak Syndrome:

58 31 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 leukocytosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001974
2 pedal edema 31 hallmark (90%) HP:0010741
3 hypotension 58 31 frequent (33%) Frequent (79-30%) HP:0002615
4 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
5 abdominal pain 58 31 frequent (33%) Frequent (79-30%) HP:0002027
6 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
7 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
8 pancreatitis 58 31 frequent (33%) Frequent (79-30%) HP:0001733
9 diarrhea 58 31 frequent (33%) Frequent (79-30%) HP:0002014
10 pulmonary edema 58 31 frequent (33%) Frequent (79-30%) HP:0100598
11 rhinorrhea 58 31 frequent (33%) Frequent (79-30%) HP:0031417
12 renal insufficiency 58 31 occasional (7.5%) Occasional (29-5%) HP:0000083
13 arrhythmia 58 31 occasional (7.5%) Occasional (29-5%) HP:0011675
14 pericarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0001701
15 cough 58 31 occasional (7.5%) Occasional (29-5%) HP:0012735
16 venous thrombosis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004936
17 myocarditis 58 31 occasional (7.5%) Occasional (29-5%) HP:0012819
18 pleural effusion 58 31 occasional (7.5%) Occasional (29-5%) HP:0002202
19 oliguria 58 31 occasional (7.5%) Occasional (29-5%) HP:0100520
20 cardiorespiratory arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0006543
21 multiple myeloma 58 31 occasional (7.5%) Occasional (29-5%) HP:0006775
22 abnormal renal tubule morphology 31 occasional (7.5%) HP:0000091
23 abnormality of the renal tubule 58 Occasional (29-5%)
24 edema of the lower limbs 58 Very frequent (99-80%)
25 constitutional symptom 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ALB C3 C4A CD22 CSF3 CXCL8

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 ADM ALB C3 CD19 CD22 CD8A
2 cardiovascular system MP:0005385 10.13 ADM ALB C3 CD19 CSF2 EDNRA
3 hematopoietic system MP:0005397 10.13 ADM C3 CD19 CD22 CD8A CSF2
4 immune system MP:0005387 10.1 ADM ALB C3 CD19 CD22 CD8A
5 endocrine/exocrine gland MP:0005379 10.07 ADM ALB C3 CD8A CSF2 EDNRA
6 mortality/aging MP:0010768 9.97 ADM ALB C3 CD19 CD22 CD8A
7 neoplasm MP:0002006 9.5 ALB CD19 CSF2 ELANE IL2 IL6
8 renal/urinary system MP:0005367 9.32 ADM ALB C3 CD19 CD8A CSF2

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
3
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
4
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
5
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
6
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
7 Anti-Infective Agents Phase 2
8 Immunotoxin HA22 Phase 2
9 Immunotoxins Phase 2
10 BB 1101 Phase 2
11 Immunologic Factors Phase 2
12 Antibodies, Monoclonal Phase 2
13 Anti-Retroviral Agents Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Analgesics Phase 2
16 Dermatologic Agents Phase 2
17 Ch14.18 monoclonal antibody Phase 2
18 Anti-HIV Agents Phase 2
19 Immunoglobulins Phase 2
20 Antibodies Phase 2
21 Interleukin-2 Phase 2
22 Antiviral Agents Phase 2
23 Keratolytic Agents Phase 2
24
Etoposide Approved Phase 1 33419-42-0 36462
25
Clofarabine Approved, Investigational Phase 1 123318-82-1 119182
26
rituximab Approved Phase 1 174722-31-7 10201696
27 Topoisomerase Inhibitors Phase 1
28 Alkylating Agents Phase 1
29 HIV Protease Inhibitors Phase 1
30 Antiemetics Phase 1
31 Gastrointestinal Agents Phase 1
32 Anti-Inflammatory Agents Phase 1
33
protease inhibitors Phase 1
34 Bendamustine Hydrochloride Phase 1
35 Etoposide phosphate Phase 1
36 glucocorticoids Phase 1
37 Antineoplastic Agents, Hormonal Phase 1
38 Hormone Antagonists Phase 1
39 Antimetabolites Phase 1
40 Hormones Phase 1
41 Antineoplastic Agents, Immunological Phase 1
42 Antirheumatic Agents Phase 1
43
Ciprofloxacin Approved, Investigational 85721-33-1 2764
44
Meropenem Approved, Investigational 119478-56-7, 96036-03-2 441130 64778
45
Amoxicillin Approved, Vet_approved 26787-78-0 33613
46
Clavulanate Approved, Vet_approved 58001-44-8 5280980
47
Tazobactam Approved 89786-04-9 123630
48
Piperacillin Approved 66258-76-2 43672
49
Vancomycin Approved 1404-90-6 441141 14969
50
Norepinephrine Approved 51-41-2 439260

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 A Phase II Study of the Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic Leukemia and Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT02338050 Phase 2
2 Randomized Phase 2 Trial Comparing Experimental Immunotherapy in Recurrent High Risk Neuroblastoma Patients With Standard Immunotherapy in Patients With Recurrent and Newly Diagnosed High Risk Neuroblastoma Terminated NCT02641782 Phase 2 antibody ch14.18;GM-CSF;IL-2 i.v.;IL-2 s.c.;Retinoic acid
3 A Phase I Trial of Bendamustine in Combination With Clofarabine and Etoposide in Pediatric Patients With Relapsed or Refractory Hematologic Malignancies Completed NCT01900509 Phase 1 Bendamustine;Clofarabine;Etoposide;Etoposide phosphate;Dexamethasone
4 A Phase I Study of DT2219ARL, A Bispecific Singe Chain Immunotoxin for the Treatment of Relapsed or Refractory CD19(+), CD22(+) B-Lineage Leukemia or Lymphoma Completed NCT00889408 Phase 1
5 A Phase I Study of Moxetumomab Pasudotox-tdfk (Lumoxiti (TM)) and Rituximab (Rituxan (R)) for Relapsed Hairy Cell Leukemia Recruiting NCT03805932 Phase 1 Moxetumomab Pasudotox-tdfk
6 Effects of Intraoperative Goal-Directed Fluid Therapy on the Incidence of Postoperative Complications Following Gastrointestinal Surgery Unknown status NCT02507557
7 Meropenem and Ciprofloxacin Dosing in the Critically Ill Patient With Septic Shock - a Single Center Pharmacokinetic Study Unknown status NCT02240277
8 Monitoring the IMmUological TOXicity of Drugs Completed NCT03480529 drug inducing arthritis, lupus, hepatitis, or capillary leak syndrom
9 Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients Completed NCT03410771 Monitor antibiotic exposure (PK profile)
10 Topical Autologous Serum Eye Drops Combined With Silicone Hydrogen Lenses for theTreatment of Corneal Epithelial Defects Completed NCT02291731 Continuous use of topical autologous serum
11 Serum Albumin, Colloid Osmotic Pressure and Endothelial Damage in Patients With End Stage Liver Disease Undergoing Orthotopic Liver Transplantation. A Retrospective Data Analysis. Completed NCT03448679
12 Contact Lens Assessment in Youth - Soft Contacts Observation of Risk and Education (CLAY-SCORE) Completed NCT03305484
13 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
14 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
15 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Recruiting NCT02965339
16 Vasoplegia During VA-ECMO for Refractory Cardiogenic Shock : Descriptive Analysis of a Retrospective Cohort Recruiting NCT03968926
17 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Active, not recruiting NCT02853682
18 US Post-Marketing Retrospective Observational Safety Study of Moxetumomab Pasudotox-tdfk (LUMOXITI)(TM) Not yet recruiting NCT04125290
19 Request to Conduct Research for Same Use of Stored Human Samples, Specimens, or Data Collected in a Terminated NCI-IRB Protocol Terminated NCT00904514

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

40
Endothelial, Liver, Kidney, Heart, Bone, Bone Marrow, Lung

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 667)
# Title Authors PMID Year
1
Intravenous Immunoglobulins Improve Survival in Monoclonal Gammopathy-Associated Systemic Capillary-Leak Syndrome. 61 52
28602874 2017
2
The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction. 61 54
18496242 2008
3
Left posterior fascicular block due to high-dose interleukin-2. 54 61
18664608 2008
4
Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). 61 54
17085290 2006
5
Validation of C1-esterase inhibitor therapy in severe capillary leak syndrome by monitoring of extravascular lung water. 61 54
14727019 2004
6
[Idiopathic anaphylaxis]. 54 61
15015747 2004
7
Managing toxicities of high-dose interleukin-2. 54 61
12469935 2002
8
Symptomatic neurological epidural metastasis with interleukin-2 therapy in metastatic renal cell carcinoma. 54 61
12400987 2002
9
Interleukin-2 as a therapeutic agent. 54 61
11837757 2001
10
Anticancer drug-induced kidney disorders. 61 54
11219485 2001
11
Relation of pro- and anti-inflammatory cytokines and the production of nitric oxide in patients receiving high-dose immunotherapy with interleukin-2. 54 61
11022123 2000
12
Pulmonary infiltrates after cytokine therapy for stem cell transplantation. Massive deposition of eosinophil major basic protein detected by immunohistochemistry. 61 54
10508829 1999
13
Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders. 61 54
10554800 1999
14
Interleukin-2-activated hematopoietic stem cell transplantation for breast cancer: investigation of dose level with clinical correlates. 61 54
9383227 1997
15
Administration of R24 monoclonal antibody and low-dose interleukin 2 for malignant melanoma. 54 61
9815532 1997
16
Phase I clinical trial with a human major histocompatibility complex nonrestricted cytotoxic T-cell line (TALL-104) in dogs with advanced tumors. 54 61
8674057 1996
17
Transcapillary forces of the subcutaneous tissue in patients treated with interleukin-2 and alpha-interferon: no capillary protein leak syndrome? 54 61
9414399 1996
18
The release of interleukin-8 during intravenous bolus treatment with interleukin-2. 61 54
7696165 1994
19
Phase Ib trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal cell carcinoma. 61 54
8012963 1994
20
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. 54 61
8110879 1994
21
Clinical observations on adoptive immunotherapy with vaccine-primed T-lymphocytes secondarily sensitized to tumor in vitro. 61 54
8439951 1993
22
[Anatomopathological findings correlated with high-dose recombinant interleukin-2. Review of the literature and description of 2 autopsy cases]. 61 54
1491889 1992
23
Interleukin-2 therapy enhances salicylate oxidation by blood granulocytes. 54 61
1954382 1991
24
Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer. 54 61
1884020 1991
25
[Interleukin immunotherapy of progression]. 61 54
1830670 1991
26
Production of tumor necrosis factor alpha and interferon gamma in interleukin-2-treated melanoma patients: correlation with clinical toxicity. 54 61
1760811 1991
27
Activation of the complement system during immunotherapy of cancer with interleukin-2: a possible explanation of the capillary leak syndrome. 61 54
2093734 1990
28
Capillary leak syndrome during low dose granulocyte-macrophage colony-stimulating factor (rh GM-CSF) treatment of a patient in a continuous febrile state. 54 61
2224143 1990
29
[The effect of corticosteroid on lymphokine-activated killer (LAK) activity and the change of membrane antigen phenotype on PBMC after IL2 incubation with reference to the evaluation in vitro]. 61 54
2376610 1990
30
Effect of human recombinant interleukin-2 on isolated rabbit femoral artery and porcine coronary artery and vein. 61 54
2282064 1990
31
Pathophysiology of cytokines. 61 54
2201818 1990
32
Successful Treatment of a Patient with Chronic Systemic Capillary Leak Syndrome, Neutropenia and Thymoma. 61
31802306 2019
33
Updates in Novel Therapies for Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). 61
31853773 2019
34
Systemic capillary leak syndrome: a rare disease becoming increasingly recognized. 61
31520774 2019
35
Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with nab-paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma. 61
31792036 2019
36
Predictors of Reopening the Sternum in Children After Cardiac Surgery. 61
31702705 2019
37
Plasmodium vivax Malaria Presenting with Acute Systemic Capillary Leak Syndrome. 61
31571465 2019
38
Moxetumomab pasudotox for hairy cell leukemia: preclinical development to FDA approval. 61
31594764 2019
39
Anasarca, steatorrhea, and hypoalbuminemia 18 years after total gastrectomy: a case report. 61
31650279 2019
40
Tagraxofusp, the first CD123-targeted therapy and first targeted treatment for blastic plasmacytoid dendritic cell neoplasm. 61
31465247 2019
41
Contextualizing the Use of Moxetumomab Pasudotox in the Treatment of Relapsed or Refractory Hairy Cell Leukemia. 61
31628266 2019
42
Moxetumomab pasudotox for the treatment of relapsed and/or refractory hairy cell leukemia. 61
31298972 2019
43
Systemic capillary leak syndrome following bosentan treatment in a patient with systemic sclerosis. 61
31012372 2019
44
FDA Approval Summary: Tagraxofusp-erzs For Treatment of Blastic Plasmacytoid Dendritic Cell Neoplasm. 61
31548341 2019
45
Key Regulatory Effect of Activated HIF-1α/VEGFA Signaling Pathway in Systemic Capillary Leak Syndrome Confirmed by Bioinformatics Analysis. 61
31545077 2019
46
Whole-Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome. 61
30289850 2019
47
Systemic Capillary Leak Syndrome Presenting With Fulminant Recurrent Cardiogenic Shock. 61
31345058 2019
48
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease). 61
31210423 2019
49
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 61
31409584 2019
50
Moxetumomab pasudotox-tdfk for relapsed/refractory hairy cell leukemia: a review of clinical considerations. 61
31134324 2019

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.84 IL6 IL2 IL15 ICOSLG ELANE CXCL8
2 12.77 IL6 IL2 IL15 EDNRA CXCL8
3
Show member pathways
12.66 IL6 IL2 IL15 ICOSLG CXCL8 CD8A
4 12.27 IL6 IL2 IL15 CSF2
5
Show member pathways
12.26 IL6 CXCL8 CSF3 CSF2
6
Show member pathways
12.26 IL6 IL2 IL15 CSF3 CSF2
7 12.18 IL6 ELANE CXCL8 CSF2
8 12.05 SERPING1 C4A C3 C1S
9 12.02 CD8A CD22 CD19 C3
10
Show member pathways
12 SERPING1 C4A C3 C1S
11
Show member pathways
11.88 SERPING1 C4A C3 C1S
12 11.82 IL6 IL15 CXCL8 CSF2
13
Show member pathways
11.81 IL6 CXCL8 CSF3 CSF2
14 11.74 IL6 IL2 CXCL8 CSF2
15 11.73 IL6 CSF3 CSF2 CD8A CD22 CD19
16 11.72 IL6 CXCL8 CSF2
17 11.72 IL2 IL15 CD8A
18
Show member pathways
11.69 IL2 CXCL8 CSF2
19 11.66 IL6 IL2 IL15 CSF2
20 11.64 IL6 IL2 CSF2 CD8A CD19
21
Show member pathways
11.58 IL6 IL2 CXCL8 CSF2
22 11.56 IL6 CXCL8 CSF3 CSF2
23 11.55 IL6 CXCL8 C3
24 11.48 IL6 CXCL8 CSF3
25 11.46 IL6 CSF3 CSF2
26 11.42 IL6 CXCL8 CSF3 CSF2
27 11.31 SERPING1 IL6 CXCL8 C4A C3 C1S
28 11.29 IL6 IL2 IL15 CSF3 CSF2 CD8A
29 11.02 IL6 IL2 IL15 CSF3 CSF2
30 10.95 IL6 IL2 IL15 CXCL8 CSF3 CSF2

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 SERPING1 IL6 IL2 IL15 ELANE CXCL8
2 blood microparticle GO:0072562 9.55 SERPING1 C4A C3 C1S ALB
3 extracellular space GO:0005615 9.44 SERPING1 IL6 IL2 IL15 ELANE CXCL8

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.88 IL6 IL2 IL15 CSF3 CSF2 ADM
2 immune system process GO:0002376 9.87 SERPING1 IL2 ICOSLG CD8A CD19 C4A
3 cellular protein metabolic process GO:0044267 9.85 IL6 C4A C3 ALB
4 cytokine-mediated signaling pathway GO:0019221 9.83 IL6 IL2 CXCL8 CSF3 CSF2
5 cellular response to lipopolysaccharide GO:0071222 9.8 IL6 CXCL8 CSF3 CSF2
6 complement activation, classical pathway GO:0006958 9.78 SERPING1 C4A C3 C1S
7 regulation of immune response GO:0050776 9.77 ICOSLG CD8A CD22 CD19 C3
8 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.76 IL6 IL15 CSF3
9 inflammatory response GO:0006954 9.73 IL6 IL15 CXCL8 C4A C3 ADM
10 positive regulation of T cell proliferation GO:0042102 9.71 IL6 IL2 IL15
11 positive regulation of immune response GO:0050778 9.58 IL15 ELANE
12 positive regulation of immunoglobulin secretion GO:0051024 9.57 IL6 IL2
13 neutrophil activation GO:0042119 9.56 IL15 CXCL8
14 positive regulation of apoptotic cell clearance GO:2000427 9.52 C4A C3
15 positive regulation of tissue remodeling GO:0034105 9.51 IL2 IL15
16 negative regulation of chemokine biosynthetic process GO:0045079 9.46 IL6 ELANE
17 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IL6 IL2 IL15 CSF2
18 regulation of complement activation GO:0030449 9.35 SERPING1 CD19 C4A C3 C1S
19 immune response GO:0006955 9.23 IL6 IL2 IL15 CXCL8 CSF3 CSF2

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.09 TPX2 SERPING1 IL6 IL2 IL15 ICOSLG
2 growth factor activity GO:0008083 9.26 IL6 IL2 CSF3 CSF2
3 cytokine activity GO:0005125 9.1 IL6 IL2 IL15 CXCL8 CSF3 CSF2

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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