MCID: CPL003
MIFTS: 42

Capillary Leak Syndrome

Categories: Bone diseases, Cardiovascular diseases, Immune diseases, Rare diseases

Aliases & Classifications for Capillary Leak Syndrome

MalaCards integrated aliases for Capillary Leak Syndrome:

Name: Capillary Leak Syndrome 12 55 44 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:14400
MeSH 44 D019559
NCIt 50 C62578
SNOMED-CT 68 87730004
UMLS 72 C0343084

Summaries for Capillary Leak Syndrome

MalaCards based summary : Capillary Leak Syndrome is related to hydrops, lactic acidosis, and sideroblastic anemia and fasciitis. An important gene associated with Capillary Leak Syndrome is IL2 (Interleukin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and bone marrow, and related phenotype is neoplasm.

Wikipedia : 75 Capillary leak syndrome is characterized by the escape of blood plasma through capillary walls, from the... more...

Related Diseases for Capillary Leak Syndrome

Diseases in the Capillary Leak Syndrome family:

Systemic Capillary Leak Syndrome

Diseases related to Capillary Leak Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 276)
# Related Disease Score Top Affiliating Genes
1 hydrops, lactic acidosis, and sideroblastic anemia 31.0 C1S ALB
2 fasciitis 30.8 IL6 CXCL8
3 perinatal necrotizing enterocolitis 30.5 IL6 CXCL8
4 acute respiratory distress syndrome 30.4 IL6 ELANE CXCL8
5 exanthem 30.4 IL6 IL2
6 kawasaki disease 30.2 IL6 ELANE ALB
7 respiratory failure 30.1 ELANE CXCL8 ALB
8 meningitis 30.1 IL6 CXCL8 ALB
9 endocarditis 30.1 IL6 CXCL8 ALB
10 brucellosis 30.1 IL6 IL2 CXCL8
11 engraftment syndrome 29.9 CXCL8 CSF2
12 necrotizing fasciitis 29.8 IL6 IL2 CXCL8
13 neutrophilia, hereditary 29.8 IL6 CSF2
14 pneumonia 29.8 IL6 ELANE CXCL8
15 acute pancreatitis 29.8 IL6 ELANE CXCL8
16 toxic shock syndrome 29.8 IL6 IL2 CXCL8 C1S
17 adult respiratory distress syndrome 29.4 IL6 ELANE CXCL8 C4A
18 myeloma, multiple 28.8 IL6 IL2 CXCL8 CSF2 ALB
19 systemic capillary leak syndrome 13.0
20 dengue disease 11.3
21 compartment syndrome 10.6
22 pyuria 10.5 CXCL8 ALB
23 noma 10.5 CXCL8 ALB
24 euthyroid sick syndrome 10.5 IL6 ALB
25 recurrent corneal erosion 10.5 IL6 CXCL8
26 pulmonary edema 10.5
27 bagassosis 10.5 IL6 CXCL8
28 acute transverse myelitis 10.5 IL6 CXCL8
29 transverse myelitis 10.5 IL6 CXCL8
30 papillary conjunctivitis 10.5 IL6 CXCL8
31 denture stomatitis 10.5 IL6 CXCL8
32 funisitis 10.4 IL6 CXCL8
33 transient arthritis 10.4 IL6 ALB
34 louse-borne relapsing fever 10.4 IL6 CXCL8
35 pyelitis 10.4 IL6 CXCL8
36 vaginitis 10.4 IL6 CXCL8
37 hand, foot and mouth disease 10.4 IL6 C4A
38 vaginal disease 10.4 IL6 CXCL8
39 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.4
40 endometrial disease 10.4 IL6 CXCL8
41 prediabetes syndrome 10.4 IL6 ALB
42 cowpox 10.4 IL6 CXCL8
43 pasteurellosis 10.4 ELANE ALB
44 radiculopathy 10.4 IL6 CXCL8
45 viral meningitis 10.4 IL6 CXCL8
46 bacteriuria 10.4 IL6 CXCL8
47 chronic ulcer of skin 10.4 ELANE ALB
48 toxicodendron dermatitis 10.4 IL2 CXCL8
49 renal hypertension 10.4 ALB ADM
50 pulpitis 10.4 IL6 CXCL8

Graphical network of the top 20 diseases related to Capillary Leak Syndrome:



Diseases related to Capillary Leak Syndrome

Symptoms & Phenotypes for Capillary Leak Syndrome

MGI Mouse Phenotypes related to Capillary Leak Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 ALB CSF2 ELANE IL2 IL6

Drugs & Therapeutics for Capillary Leak Syndrome

Drugs for Capillary Leak Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
4
Aldesleukin Approved Phase 2 85898-30-2, 110942-02-4
5
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
6
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
7 Anti-Infective Agents Phase 2
8 Peripheral Nervous System Agents Phase 2
9 BB 1101 Phase 2
10 Immunotoxin HA22 Phase 2
11 Immunotoxins Phase 2
12 Analgesics Phase 2
13 Analgesics, Non-Narcotic Phase 2
14 Antibodies Phase 2
15 Ch14.18 monoclonal antibody Phase 2
16 Immunologic Factors Phase 2
17 Keratolytic Agents Phase 2
18 Immunoglobulins Phase 2
19 Anti-HIV Agents Phase 2
20 Dermatologic Agents Phase 2
21 Anti-Retroviral Agents Phase 2
22 Antibodies, Monoclonal Phase 2
23 Antiviral Agents Phase 2
24 Interleukin-2 Phase 2
25
Clofarabine Approved, Investigational Phase 1 123318-82-1 119182
26
Etoposide Approved Phase 1 33419-42-0 36462
27
rituximab Approved Phase 1 174722-31-7 10201696
28 Topoisomerase Inhibitors Phase 1
29 Antiemetics Phase 1
30 Anti-Inflammatory Agents Phase 1
31 Alkylating Agents Phase 1
32 Gastrointestinal Agents Phase 1
33 HIV Protease Inhibitors Phase 1
34 Antineoplastic Agents, Phytogenic Phase 1
35 glucocorticoids Phase 1
36 Hormones Phase 1
37
protease inhibitors Phase 1
38 Antineoplastic Agents, Hormonal Phase 1
39 Hormone Antagonists Phase 1
40 Etoposide phosphate Phase 1
41 Antineoplastic Agents, Alkylating Phase 1
42 Antimetabolites, Antineoplastic Phase 1
43 Antimetabolites Phase 1
44 Bendamustine Hydrochloride Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
46 Antineoplastic Agents, Immunological Phase 1
47 Antirheumatic Agents Phase 1
48
Ciprofloxacin Approved, Investigational 85721-33-1 2764
49
Meropenem Approved, Investigational 119478-56-7, 96036-03-2 64778 441130
50
Clavulanate Approved, Vet_approved 58001-44-8 5280980

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Phase II Study of the Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox (CAT-8015, HA22) in Children With B-lineage Acute Lymphoblastic Leukemia and Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation Terminated NCT02338050 Phase 2
2 Randomized Phase 2 Trial Comparing Experimental Immunotherapy in Recurrent High Risk Neuroblastoma Patients With Standard Immunotherapy in Patients With Recurrent and Newly Diagnosed High Risk Neuroblastoma Terminated NCT02641782 Phase 2 antibody ch14.18;GM-CSF;IL-2 i.v.;IL-2 s.c.;Retinoic acid
3 A Phase I Trial of Bendamustine in Combination With Clofarabine and Etoposide in Pediatric Patients With Relapsed or Refractory Hematologic Malignancies Completed NCT01900509 Phase 1 Bendamustine;Clofarabine;Etoposide;Etoposide phosphate;Dexamethasone
4 A Phase I Study of DT2219ARL, A Bispecific Singe Chain Immunotoxin for the Treatment of Relapsed or Refractory CD19(+), CD22(+) B-Lineage Leukemia or Lymphoma Completed NCT00889408 Phase 1
5 A Phase I Study of Moxetumomab Pasudotox-tdfk (Lumoxiti) and Rituximab (Rituxan (R)) for Relapsed Hairy Cell Leukemia Not yet recruiting NCT03805932 Phase 1 Moxetumomab Pasudotox-tdfk
6 Meropenem and Ciprofloxacin Dosing in the Critically Ill Patient With Septic Shock - a Single Center Pharmacokinetic Study Unknown status NCT02240277
7 Effects of Intraoperative Goal-Directed Fluid Therapy on the Incidence of Postoperative Complications Following Gastrointestinal Surgery Unknown status NCT02507557
8 Monitoring the IMmUological TOXicity of Drugs Completed NCT03480529 drug inducing arthritis, lupus, hepatitis, or capillary leak syndrom
9 Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients Completed NCT03410771 Monitor antibiotic exposure (PK profile)
10 Serum Albumin, Colloid Osmotic Pressure and Endothelial Damage in Patients With End Stage Liver Disease Undergoing Orthotopic Liver Transplantation. A Retrospective Data Analysis. Completed NCT03448679
11 Studies in the Pathogenesis of Systemic Capillary Leak Syndrome Recruiting NCT00936325
12 Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass Recruiting NCT02965339
13 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
14 Characterization of Endothelial Dysfunction as a Function of Hyperaemia of the Brachial Artery During Cardiac Surgery Active, not recruiting NCT02853682
15 Vasoplegia During VA-ECMO for Refractory Cardiogenic Shock : Descriptive Analysis of a Retrospective Cohort Not yet recruiting NCT03968926
16 Request to Conduct Research for Same Use of Stored Human Samples, Specimens, or Data Collected in a Terminated NCI-IRB Protocol Terminated NCT00904514

Search NIH Clinical Center for Capillary Leak Syndrome

Cochrane evidence based reviews: capillary leak syndrome

Genetic Tests for Capillary Leak Syndrome

Anatomical Context for Capillary Leak Syndrome

MalaCards organs/tissues related to Capillary Leak Syndrome:

41
Endothelial, Bone, Bone Marrow, Liver, Lung, T Cells, Kidney

Publications for Capillary Leak Syndrome

Articles related to Capillary Leak Syndrome:

(show top 50) (show all 651)
# Title Authors PMID Year
1
The response of antithrombin III activity after supplementation decreases in proportion to the severity of sepsis and liver dysfunction. 9 38
18496242 2008
2
Left posterior fascicular block due to high-dose interleukin-2. 9 38
18664608 2008
3
Cytokine-associated angioedema syndromes including episodic angioedema with eosinophilia (Gleich's Syndrome). 9 38
17085290 2006
4
Validation of C1-esterase inhibitor therapy in severe capillary leak syndrome by monitoring of extravascular lung water. 9 38
14727019 2004
5
[Idiopathic anaphylaxis]. 9 38
15015747 2004
6
Managing toxicities of high-dose interleukin-2. 9 38
12469935 2002
7
Symptomatic neurological epidural metastasis with interleukin-2 therapy in metastatic renal cell carcinoma. 9 38
12400987 2002
8
Interleukin-2 as a therapeutic agent. 9 38
11837757 2001
9
Anticancer drug-induced kidney disorders. 9 38
11219485 2001
10
Relation of pro- and anti-inflammatory cytokines and the production of nitric oxide in patients receiving high-dose immunotherapy with interleukin-2. 9 38
11022123 2000
11
Pulmonary infiltrates after cytokine therapy for stem cell transplantation. Massive deposition of eosinophil major basic protein detected by immunohistochemistry. 9 38
10508829 1999
12
Activation of endothelium by immunotherapy with interleukin-2 in patients with malignant disorders. 9 38
10554800 1999
13
Interleukin-2-activated hematopoietic stem cell transplantation for breast cancer: investigation of dose level with clinical correlates. 9 38
9383227 1997
14
Administration of R24 monoclonal antibody and low-dose interleukin 2 for malignant melanoma. 9 38
9815532 1997
15
Phase I clinical trial with a human major histocompatibility complex nonrestricted cytotoxic T-cell line (TALL-104) in dogs with advanced tumors. 9 38
8674057 1996
16
Transcapillary forces of the subcutaneous tissue in patients treated with interleukin-2 and alpha-interferon: no capillary protein leak syndrome? 9 38
9414399 1996
17
The release of interleukin-8 during intravenous bolus treatment with interleukin-2. 9 38
7696165 1994
18
Phase Ib trial of pentoxifylline and ciprofloxacin in patients treated with interleukin-2 and lymphokine-activated killer cell therapy for metastatic renal cell carcinoma. 9 38
8012963 1994
19
Capillary leak syndrome associated with elevated IL-2 serum levels after allogeneic bone marrow transplantation. 9 38
8110879 1994
20
Clinical observations on adoptive immunotherapy with vaccine-primed T-lymphocytes secondarily sensitized to tumor in vitro. 9 38
8439951 1993
21
[Anatomopathological findings correlated with high-dose recombinant interleukin-2. Review of the literature and description of 2 autopsy cases]. 9 38
1491889 1992
22
Interleukin-2 therapy enhances salicylate oxidation by blood granulocytes. 9 38
1954382 1991
23
Administration of interleukin-2 (IL-2) results in increased plasma concentrations of IL-5 and eosinophilia in patients with cancer. 9 38
1884020 1991
24
[Interleukin immunotherapy of progression]. 9 38
1830670 1991
25
Production of tumor necrosis factor alpha and interferon gamma in interleukin-2-treated melanoma patients: correlation with clinical toxicity. 9 38
1760811 1991
26
Activation of the complement system during immunotherapy of cancer with interleukin-2: a possible explanation of the capillary leak syndrome. 9 38
2093734 1990
27
Capillary leak syndrome during low dose granulocyte-macrophage colony-stimulating factor (rh GM-CSF) treatment of a patient in a continuous febrile state. 9 38
2224143 1990
28
[The effect of corticosteroid on lymphokine-activated killer (LAK) activity and the change of membrane antigen phenotype on PBMC after IL2 incubation with reference to the evaluation in vitro]. 9 38
2376610 1990
29
Effect of human recombinant interleukin-2 on isolated rabbit femoral artery and porcine coronary artery and vein. 9 38
2282064 1990
30
Pathophysiology of cytokines. 9 38
2201818 1990
31
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 38
31409584 2019
32
Handling shock in idiopathic systemic capillary leak syndrome (Clarkson's disease): less is more. 38
31154613 2019
33
Moxetumomab pasudotox for the treatment of relapsed and/or refractory hairy cell leukemia. 38
31298972 2019
34
Moxetumomab pasudotox-tdfk for relapsed/refractory hairy cell leukemia: a review of clinical considerations. 38
31134324 2019
35
Whole-Exome Sequencing of Adult and Pediatric Cohorts of the Rare Vascular Disorder Systemic Capillary Leak Syndrome. 38
30289850 2019
36
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease). 38
31210423 2019
37
Systemic Capillary Leak Syndrome Presenting With Fulminant Recurrent Cardiogenic Shock. 38
31345058 2019
38
Chemotherapy-induced skin toxicity and capillary leak syndrome. 38
30847892 2019
39
Handling shock in idiopathic systemic capillary leak syndrome (Clarkson's disease) less is more: reply. 38
31342454 2019
40
Handling shock in idiopathic systemic capillary leak syndrome (Clarkson's disease): less is more-comment. 38
31273675 2019
41
Real-world safety experience of tevagrastim/ratiograstim/biograstim and tbo-filgrastim, short-acting recombinant human granulocyte colony-stimulating factors. 38
30443809 2019
42
C1 esterase inhibitor in pediatric cardiac surgery with cardiopulmonary bypass plays a vital role in activation of the complement system. 38
31278424 2019
43
Panophthalmitis in a patient with dengue fever. 38
31164382 2019
44
Dengue: Uncommon Neurological Presentations of a Common Tropical Illness. 38
31435146 2019
45
[Clinical analysis of secondary hemophagocytic lymphohistiocytosis complicated with capillary leak syndrome]. 38
31340624 2019
46
Systemic Capillary Leak Syndrome (Clarkson's Disease) as a Complication of Anti-Programmed Death 1 Immunotherapy. 38
31122567 2019
47
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies. 38
31097308 2019
48
Capillary leak syndrome: a cytokine and catecholamine storm? 38
31010471 2019
49
Capillary leak syndrome with tamponade. 38
31149829 2019
50
Colchicine: An Impressive Effect on Posttransplant Capillary Leak Syndrome and Renal Failure. 38
31000685 2019

Variations for Capillary Leak Syndrome

Expression for Capillary Leak Syndrome

Search GEO for disease gene expression data for Capillary Leak Syndrome.

Pathways for Capillary Leak Syndrome

Pathways related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.76 IL6 IL2 ELANE CXCL8 CSF2 C4A
2
Show member pathways
12.65 IL6 IL2 CXCL8 C4A
3
Show member pathways
12.36 IL6 IL2 CSF2
4 12.15 IL6 IL2 CSF2
5
Show member pathways
12.13 IL6 IL2 ALB
6
Show member pathways
12.12 IL6 CXCL8 CSF2
7 11.98 IL6 CXCL8 C4A
8 11.94 IL6 ELANE CXCL8 CSF2
9
Show member pathways
11.85 IL6 CSF2 C1S
10 11.82 IL6 IL2 CXCL8
11 11.8 IL6 IL2 CSF2
12 11.73 IL6 CXCL8 CSF2
13
Show member pathways
11.68 IL6 CXCL8 CSF2
14 11.67 IL6 CXCL8 CSF2
15 11.6 IL6 CXCL8 CSF2
16
Show member pathways
11.55 IL2 CXCL8 CSF2
17 11.52 IL6 IL2 CSF2
18 11.48 IL6 IL2 CSF2
19 11.41 IL6 CXCL8 CSF2
20 11.37 IL6 IL2 CXCL8 CSF2
21 11.27 IL6 CXCL8 CSF2
22 11.16 IL6 CXCL8
23 11.15 CXCL8 CSF2
24 11.14 IL6 CXCL8 C4A C1S
25 10.9 IL6 IL2 CSF2
26 10.86 IL6 CXCL8
27 10.85 IL6 IL2 CXCL8 CSF2
28 10.8 IL6 IL2 CXCL8 CSF2
29
Show member pathways
10.72 IL6 IL2 CXCL8 CSF2

GO Terms for Capillary Leak Syndrome

Cellular components related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 IL6 IL2 ELANE CXCL8 CSF2 C4A
2 blood microparticle GO:0072562 9.33 C4A C1S ALB
3 extracellular space GO:0005615 9.28 IL6 IL2 ELANE CXCL8 CSF2 C4A

Biological processes related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 IL6 IL2 CSF2 ADM
2 immune response GO:0006955 9.62 IL6 IL2 CXCL8 CSF2
3 cellular protein metabolic process GO:0044267 9.61 IL6 C4A ALB
4 cellular response to lipopolysaccharide GO:0071222 9.54 IL6 CXCL8 CSF2
5 receptor internalization GO:0031623 9.46 CXCL8 ADM
6 cytokine-mediated signaling pathway GO:0019221 9.46 IL6 IL2 CXCL8 CSF2
7 positive regulation of immunoglobulin secretion GO:0051024 9.26 IL6 IL2
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.13 IL6 IL2 CSF2
9 negative regulation of chemokine biosynthetic process GO:0045079 8.62 IL6 ELANE

Molecular functions related to Capillary Leak Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.16 ELANE C1S
2 growth factor activity GO:0008083 9.13 IL6 IL2 CSF2
3 cytokine activity GO:0005125 8.92 IL6 IL2 CXCL8 CSF2

Sources for Capillary Leak Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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