MCID: CPL002
MIFTS: 25

Capillary Lymphangioma

Categories: Cancer diseases, Cardiovascular diseases, Immune diseases, Skin diseases

Aliases & Classifications for Capillary Lymphangioma

MalaCards integrated aliases for Capillary Lymphangioma:

Name: Capillary Lymphangioma 12 15 72
Cutaneous Lymphangioma 12
Lymphangioma of Skin 72

Classifications:



External Ids:

Disease Ontology 12 DOID:2286
NCIt 50 C27509
UMLS 72 C0334543 C1333176

Summaries for Capillary Lymphangioma

MalaCards based summary : Capillary Lymphangioma, also known as cutaneous lymphangioma, is related to lymphangioma and lymphatic malformations. An important gene associated with Capillary Lymphangioma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways is Angiogenesis (CST). Affiliated tissues include skin and tongue, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Capillary Lymphangioma

Graphical network of the top 20 diseases related to Capillary Lymphangioma:



Diseases related to Capillary Lymphangioma

Symptoms & Phenotypes for Capillary Lymphangioma

MGI Mouse Phenotypes related to Capillary Lymphangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 FLT4 LYVE1 PECAM1 PROX1 VWF
2 digestive/alimentary MP:0005381 9.46 FLT4 PECAM1 PROX1 VWF
3 hematopoietic system MP:0005397 9.43 CD34 LYVE1 NTRK1 PECAM1 PROX1 VWF
4 immune system MP:0005387 9.17 CD34 FLT4 LYVE1 NTRK1 PECAM1 PROX1

Drugs & Therapeutics for Capillary Lymphangioma

Search Clinical Trials , NIH Clinical Center for Capillary Lymphangioma

Genetic Tests for Capillary Lymphangioma

Anatomical Context for Capillary Lymphangioma

MalaCards organs/tissues related to Capillary Lymphangioma:

41
Skin, Tongue

Publications for Capillary Lymphangioma

Articles related to Capillary Lymphangioma:

# Title Authors PMID Year
1
[Diagnosis and surgical treatment of cervical lymphangioma]. 38
20223116 2009
2
Lymphangioma circumscriptum of the vulva: a review of the literature. 38
12738156 2003
3
[Surgical analysis of mediastinal lymphangioma--analysis of 7 cases]. 38
1613288 1992
4
[A capillary lymphangioma of the vestibular portion of the larynx]. 38
5161795 1971
5
Lymphangioma of skin. A review of 65 cases. 38
5484713 1970
6
Capillary lymphangioma of the tongue complicated by glossitis. 38
13753050 1961
7
[Surgical failure in Torok's congenital varicose capillary lymphangioma]. 38
14405823 1959

Variations for Capillary Lymphangioma

Expression for Capillary Lymphangioma

Search GEO for disease gene expression data for Capillary Lymphangioma.

Pathways for Capillary Lymphangioma

Pathways related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 VWF PROX1 PECAM1 FLT4

GO Terms for Capillary Lymphangioma

Cellular components related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.26 NTRK1 LYVE1 FLT4 CD34
2 cell periphery GO:0071944 8.8 PECAM1 LYVE1 CD34

Biological processes related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.56 VWF PECAM1 LYVE1 CD34
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.49 NTRK1 FLT4
3 circadian rhythm GO:0007623 9.48 PROX1 NTRK1
4 response to wounding GO:0009611 9.46 VWF LYVE1
5 positive regulation of endothelial cell proliferation GO:0001938 9.43 PROX1 FLT4
6 response to nutrient levels GO:0031667 9.4 PROX1 NTRK1
7 negative regulation of neuron death GO:1901215 9.37 NTRK1 CD34
8 positive regulation of endothelial cell migration GO:0010595 9.32 PROX1 FLT4
9 lymphangiogenesis GO:0001946 9.16 PROX1 FLT4
10 lymph vessel development GO:0001945 8.96 PROX1 FLT4
11 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Molecular functions related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.26 VWF PECAM1 NTRK1 FLT4
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 NTRK1 FLT4
3 transmembrane signaling receptor activity GO:0004888 8.32 LYVE1

Sources for Capillary Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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