MCID: CPL002
MIFTS: 26

Capillary Lymphangioma

Categories: Cancer diseases, Cardiovascular diseases, Immune diseases, Skin diseases

Aliases & Classifications for Capillary Lymphangioma

MalaCards integrated aliases for Capillary Lymphangioma:

Name: Capillary Lymphangioma 12 15 74
Cutaneous Lymphangioma 12
Lymphangioma of Skin 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2286
NCIt 51 C27509

Summaries for Capillary Lymphangioma

MalaCards based summary : Capillary Lymphangioma, also known as cutaneous lymphangioma, is related to microcystic lymphatic malformation and glossitis. An important gene associated with Capillary Lymphangioma is PROX1 (Prospero Homeobox 1), and among its related pathways/superpathways is Angiogenesis (CST). The drugs Miconazole and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, endothelial and tongue, and related phenotype is cardiovascular system.

Related Diseases for Capillary Lymphangioma

Diseases related to Capillary Lymphangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 microcystic lymphatic malformation 11.9
2 glossitis 9.9
3 lymphangioma 9.9
4 noonan syndrome 1 9.9
5 thrombocytopenia 9.9
6 hypopyon 9.9
7 lymphangiectasis 9.9
8 lymphangiomatosis 9.9
9 pseudo-turner syndrome 9.9
10 acquired hemangioma 9.8 LYVE1 PROX1
11 lymphangiosarcoma 9.7 LYVE1 PROX1
12 kaposiform hemangioendothelioma 9.6 PECAM1 PROX1
13 angiosarcoma 9.4 PECAM1 PROX1
14 hemangioma 9.4 LYVE1 PECAM1 PROX1

Graphical network of the top 20 diseases related to Capillary Lymphangioma:



Diseases related to Capillary Lymphangioma

Symptoms & Phenotypes for Capillary Lymphangioma

MGI Mouse Phenotypes related to Capillary Lymphangioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 8.8 LYVE1 PECAM1 PROX1

Drugs & Therapeutics for Capillary Lymphangioma

Drugs for Capillary Lymphangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 5284616 6436030
3
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
4 Anti-Bacterial Agents Phase 2
5 Anti-Infective Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Immunologic Factors Phase 2
8 Antibiotics, Antitubercular Phase 2
9 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy Study of Sirolimus in Complicated Vascular Anomalies Active, not recruiting NCT00975819 Phase 2 sirolimus

Search NIH Clinical Center for Capillary Lymphangioma

Genetic Tests for Capillary Lymphangioma

Anatomical Context for Capillary Lymphangioma

MalaCards organs/tissues related to Capillary Lymphangioma:

42
Skin, Endothelial, Tongue

Publications for Capillary Lymphangioma

Articles related to Capillary Lymphangioma:

(show all 18)
# Title Authors Year
1
Cutaneous lymphangioma circumscriptum: The relevance of clinical, dermoscopic, radiological, and histological assessments. ( 30997047 )
2019
2
Dermoscopy of cutaneous lymphangioma circumscriptum. ( 28515992 )
2017
3
Cutaneous Lymphangioma circumscriptum - dermoscopic features. ( 25831002 )
2015
4
Cutaneous lymphangioma circumscriptum with marked blood presence: histopathologic evaluation of the endothelial cells. ( 24556333 )
2014
5
What is your diagnosis? Cutaneous lymphangioma. ( 23402405 )
2013
6
Hypopyon-like features: new dermoscopic criteria in the differential diagnosis of cutaneous lymphangioma circumscriptum and haemangiomas? ( 21645121 )
2012
7
Identification of equine cutaneous lymphangioma by application of a lymphatic endothelial cell marker. ( 20042195 )
2010
8
Cutaneous lymphangioma as a diagnostic clue for thoracic lymphangiomatosis. ( 20500793 )
2010
9
Cutaneous lymphangioma circumscriptum: frog spawn on the skin. ( 19930489 )
2009
10
Dermoscopic-histopathologic correlation of cutaneous lymphangioma circumscriptum. ( 19075163 )
2008
11
Dermoscopic features of cutaneous lymphangioma circumscriptum. ( 16792655 )
2006
12
"Occult cutaneous lymphangiectasis": an unusual case of cutaneous lymphangioma. ( 12361133 )
2002
13
Cutaneous lymphangioma in a young Standardbred mare. ( 10661392 )
2000
14
Cutaneous lymphangioma and amegakaryocytic thrombocytopenia in Noonan syndrome. ( 2036745 )
1991
15
Cutaneous lymphangioma in a young dog. ( 17423917 )
1991
16
Cutaneous lymphangioma. ( 831620 )
1977
17
CUTANEOUS LYMPHANGIOMA. ( 14104374 )
1964
18
Capillary lymphangioma of the tongue complicated by glossitis. ( 13753050 )
1961

Variations for Capillary Lymphangioma

Expression for Capillary Lymphangioma

Search GEO for disease gene expression data for Capillary Lymphangioma.

Pathways for Capillary Lymphangioma

Pathways related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.57 PECAM1 PROX1

GO Terms for Capillary Lymphangioma

Cellular components related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 LYVE1 PECAM1

Biological processes related to Capillary Lymphangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 8.62 LYVE1 PECAM1

Sources for Capillary Lymphangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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