MCID: CPL004
MIFTS: 31

Caplan's Syndrome

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Caplan's Syndrome

MalaCards integrated aliases for Caplan's Syndrome:

Name: Caplan's Syndrome 12 74 15 17
Caplan Syndrome 12 44 71
Rheumatoid Pneumoconiosis 12
Caplan's Disease 12
Caplans Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10326
MeSH 44 D002205
SNOMED-CT 67 111280008
UMLS 71 C0006915

Summaries for Caplan's Syndrome

Disease Ontology : 12 A pneumoconiosis that results in humans that also have rheumatoid arthritis.

MalaCards based summary : Caplan's Syndrome, also known as caplan syndrome, is related to pneumoconiosis and rheumatoid arthritis. An important gene associated with Caplan's Syndrome is FAS (Fas Cell Surface Death Receptor), and among its related pathways/superpathways are Th17 cell differentiation and Human T-cell leukemia virus 1 infection. Affiliated tissues include eye and t cells.

Wikipedia : 74 Caplan's syndrome (or Caplan disease or rheumatoid pneumoconiosis) is a combination of rheumatoid... more...

Related Diseases for Caplan's Syndrome

Diseases related to Caplan's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 30.8 MUC5B HLA-DRB1 FAS
2 rheumatoid arthritis 29.1 HLA-DRB1 FOXP3 FAS CD4
3 anthracosis 10.6
4 silicosis 10.4
5 postinflammatory pulmonary fibrosis 10.1 MUC5B ELMOD2
6 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 HLA-A FAS
7 asbestosis 10.1
8 asbestos intoxication 10.1
9 guillain-barre syndrome 10.1 HLA-DRB1 FAS
10 tropical spastic paraparesis 10.1 HLA-A FOXP3
11 postherpetic neuralgia 10.0 HLA-DRB1 HLA-A
12 htlv-1 associated myelopathy/tropical spastic paraparesis 10.0 HLA-DRB1 HLA-A
13 nontuberculous mycobacterial lung disease 10.0 HLA-DRB1 HLA-A
14 mental retardation, autosomal dominant 40 10.0 HLA-DRB1 HLA-A
15 pityriasis rosea 10.0 HLA-DRB1 HLA-A
16 subacute lymphocytic thyroiditis 10.0 FAS CD4
17 pars planitis 10.0 HLA-DRB1 HLA-A
18 human cytomegalovirus infection 10.0 HLA-A FAS
19 red cell aplasia 10.0 HLA-DRB1 HLA-A
20 bird fancier's lung 10.0 SPPL2C CD4
21 alveolar echinococcosis 10.0 HLA-DRB1 HLA-A
22 paraneoplastic pemphigus 10.0 HLA-DRB1 HLA-A
23 autoimmune atherosclerosis 10.0 FOXP3 CD4
24 pure red-cell aplasia 10.0 HLA-DRB1 HLA-A
25 autoimmune gastritis 10.0 HLA-DRB1 HLA-A
26 hemopericardium 10.0
27 pericardium cancer 10.0
28 arthritis 10.0
29 acute myocarditis 10.0 FAS CD4
30 autoimmune neuropathy 9.9 FOXP3 CD4
31 dacryoadenitis 9.9 FOXP3 CD4
32 immunodeficiency 41 with lymphoproliferation and autoimmunity 9.9 FOXP3 CD4
33 orchitis 9.9 FOXP3 CD4
34 filarial elephantiasis 9.9 FOXP3 CD4
35 legume allergy 9.9 FOXP3 CD4
36 relapsing-remitting multiple sclerosis 9.9 HLA-DRB1 FOXP3 FAS
37 renal cell carcinoma, nonpapillary 9.9
38 parkinsonism 9.9
39 mitral valve insufficiency 9.9
40 pericarditis 9.9
41 enthesopathy 9.9
42 adenocarcinoma 9.9
43 pulmonary fibrosis 9.9
44 systemic scleroderma 9.9
45 lung disease 9.9
46 vasculitis 9.9
47 amyloidosis 9.9
48 amyloidosis aa 9.9
49 fruit allergy 9.9 FOXP3 CD4
50 t-cell adult acute lymphocytic leukemia 9.9 FOXP3 CD4

Graphical network of the top 20 diseases related to Caplan's Syndrome:



Diseases related to Caplan's Syndrome

Symptoms & Phenotypes for Caplan's Syndrome

Drugs & Therapeutics for Caplan's Syndrome

Search Clinical Trials , NIH Clinical Center for Caplan's Syndrome

Cochrane evidence based reviews: caplan syndrome

Genetic Tests for Caplan's Syndrome

Anatomical Context for Caplan's Syndrome

MalaCards organs/tissues related to Caplan's Syndrome:

40
Eye, T Cells

Publications for Caplan's Syndrome

Articles related to Caplan's Syndrome:

(show top 50) (show all 119)
# Title Authors PMID Year
1
Synchronous Caplan's syndrome, pulmonary adenocarcinoma and carcinoid tumorlet. 61
32789928 2020
2
Amyloid A amyloidosis in a patient with Caplan's syndrome, with special reference to genetic predisposition. 61
33087017 2020
3
Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome. 61
31653636 2019
4
A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. 61
30023036 2018
5
Erasmus Syndrome: Association of Silicosis and Systemic Sclerosis. 61
29854640 2018
6
[Guideline (S2k, AWMF) of the Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin and the Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin "Diagnostics and Expert Opinion in the Occupational Disease No. 4101 Silicosis (Including Coal Worker's Pneumoconiosis)"]. 61
27931056 2016
7
An interesting finding of multiple calcified pulmonary nodules in a patient with rheumatoid arthritis. 61
30364404 2016
8
What to do with all of these lung nodules? 61
24914609 2014
9
[Caplan's syndrome: rarely presenting as <<pulmorenal>> syndrome]. 61
24568764 2014
10
Environmental factors producing autoimmune dysregulation--chronic activation of T cells caused by silica exposure. 61
22226303 2012
11
[Rheumatoid arthritis and interstitial lung alterations - a clear case, isn't it?]. 61
21614765 2011
12
Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients. 61
21329560 2011
13
Rheumatoid pneumoconiosis (Caplan's syndrome). 61
20493416 2010
14
Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation. 61
19820822 2009
15
[Caplan's syndrome in marble workers as occupational disease]. 61
19899255 2009
16
Severe mitral regurgitation in a patient with a bluish right sclera: an 'extension' of Caplan's syndrome to the heart and eye. 61
19237064 2009
17
Immunological effects of silica and asbestos. 61
17764616 2007
18
Parkinsonism in Caplan's syndrome. 61
16688603 2006
19
[New possibilities of making the diagnosis of Caplan syndrome]. 61
17278785 2006
20
[Caplan's syndrome: case report]. 61
16808317 2005
21
[Effects on the lung due to underground coal mining work]. 61
14961440 2004
22
Computed tomography findings of Caplan syndrome. 61
14501367 2003
23
[Caplan's syndrome]. 61
10422515 1998
24
[Changes in the respiratory system of patients with rheumatoid arthritis--personal observations]. 61
9658882 1998
25
[Pleural and pulmonary changes within the scope of rheumatoid arthritis]. 61
8975281 1996
26
Case report: recurrent pneumothorax in a patient with rheumatoid arthritis. 61
8074134 1994
27
[Biventricular inflow tract compression by chronic organized hemopericardium in Caplan syndrome]. 61
7927126 1994
28
[Silicosis and Caplan's syndrome]. 61
8152046 1994
29
[Pleuropulmonary manifestations of rheumatoid arthritis. A casuistic reminder]. 61
8460435 1993
30
Unusual occupational rheumatologic and musculoskeletal disorders. 61
1496427 1992
31
Small airway disease in rheumatoid arthritis. 61
1306077 1992
32
Caplan's syndrome. 61
1810363 1991
33
[A case of Caplan's syndrome in a miner]. 61
2333604 1990
34
[Errors in the evaluation of osteoarticular symptoms]. 61
2800390 1989
35
Caplan's syndrome. 61
2661027 1989
36
Pleuropulmonary necrobiotic rheumatoid nodules. A review and clinicopathological study of six patients. 61
3713605 1986
37
[Structure of rheumatic diseases among the workers of an industrial enterprise (based on epidemiological research data)]. 61
2938299 1986
38
Kaolinosis: a radiological review. 61
4064542 1985
39
[Caplan's syndrome. A case without persistent pneumoconiosis or symptom producing rheumatoid arthritis]. 61
6730051 1984
40
HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome. 61
6577907 1983
41
HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome. 61
91226 1979
42
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up. 61
483218 1979
43
Prevalence of rheumatoid pneumoconiosis (Caplan's syndrome) in metal miners. 61
455199 1979
44
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis. 61
746502 1978
45
[Caplan's syndrome (2 personal cases)]. 61
756257 1977
46
Pneumoconiosis and Rheumatoid arthritis (Caplan's syndrome). 61
326283 1977
47
[Caplan's syndrome in miners (author's transl)]. 61
844061 1977
48
[Caplan's syndrome]. 61
613004 1977
49
Caplan's syndrome in miners. 61
413171 1977
50
Rheumatoid pericarditis possibly associated with Caplan's syndrome. 61
1049236 1976

Variations for Caplan's Syndrome

Expression for Caplan's Syndrome

Search GEO for disease gene expression data for Caplan's Syndrome.

Pathways for Caplan's Syndrome

Pathways related to Caplan's Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 HLA-DRB1 FOXP3 CD4
2 11.84 HLA-DRB1 HLA-A CD4
3
Show member pathways
11.76 HLA-DRB1 HLA-A FOXP3 FAS CD4
4 11.61 HLA-DRB1 HLA-A CD4
5
Show member pathways
11.39 HLA-DRB1 CD4
6
Show member pathways
11.38 HLA-DRB1 HLA-A CD4
7 11.31 MUC5B ELMOD2
8
Show member pathways
11.17 HLA-DRB1 HLA-A CD4
9 11.14 FOXP3 CD4
10
Show member pathways
11.01 FOXP3 FAS
11 10.87 HLA-DRB1 CD4
12 10.82 HLA-DRB1 CD4

GO Terms for Caplan's Syndrome

Cellular components related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.56 SPPL2C HLA-DRB1 HLA-A CD4
2 cell surface GO:0009986 9.26 HLA-DRB1 HLA-A FAS CD4
3 ER to Golgi transport vesicle membrane GO:0012507 9.16 HLA-DRB1 HLA-A
4 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 SPPL2C HLA-DRB1 HLA-A

Biological processes related to Caplan's Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 HLA-DRB1 HLA-A FAS CD4
2 positive regulation of protein phosphorylation GO:0001934 9.63 HLA-DRB1 FAS CD4
3 T cell activation GO:0042110 9.52 FOXP3 CD4
4 antigen processing and presentation GO:0019882 9.51 HLA-DRB1 HLA-A
5 negative regulation of T cell proliferation GO:0042130 9.49 HLA-DRB1 FOXP3
6 negative regulation of interferon-gamma production GO:0032689 9.48 HLA-DRB1 FOXP3
7 positive regulation of T cell mediated cytotoxicity GO:0001916 9.43 HLA-DRB1 HLA-A
8 macrophage differentiation GO:0030225 9.4 HLA-DRB1 CD4
9 positive regulation of viral entry into host cell GO:0046598 9.32 HLA-DRB1 CD4
10 detection of bacterium GO:0016045 9.26 HLA-DRB1 HLA-A
11 positive regulation of monocyte differentiation GO:0045657 9.16 HLA-DRB1 CD4
12 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831 8.96 HLA-DRB1 FOXP3
13 T cell receptor signaling pathway GO:0050852 8.92 HLA-DRB1 HLA-A FOXP3 CD4

Molecular functions related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DRB1 HLA-A
2 MHC class II protein complex binding GO:0023026 8.96 HLA-DRB1 CD4
3 T cell receptor binding GO:0042608 8.62 HLA-DRB1 HLA-A

Sources for Caplan's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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