MCID: CPL004
MIFTS: 29

Caplan's Syndrome

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Caplan's Syndrome

MalaCards integrated aliases for Caplan's Syndrome:

Name: Caplan's Syndrome 12 76 15
Caplan Syndrome 12 44 73
Rheumatoid Pneumoconiosis 12
Caplan's Disease 12
Caplans Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10326
MeSH 44 D002205
UMLS 73 C0006915

Summaries for Caplan's Syndrome

Disease Ontology : 12 A pneumoconiosis that results in humans that also have rheumatoid arthritis.

MalaCards based summary : Caplan's Syndrome, also known as caplan syndrome, is related to pneumoconiosis and stevens-johnson syndrome/toxic epidermal necrolysis. An important gene associated with Caplan's Syndrome is FAS (Fas Cell Surface Death Receptor), and among its related pathways/superpathways are Allograft rejection and Influenza A. Affiliated tissues include bone, heart and eye.

Wikipedia : 76 Caplan''s syndrome (or Caplan disease or rheumatoid pneumoconiosis) is a combination of rheumatoid... more...

Related Diseases for Caplan's Syndrome

Graphical network of the top 20 diseases related to Caplan's Syndrome:



Diseases related to Caplan's Syndrome

Symptoms & Phenotypes for Caplan's Syndrome

Drugs & Therapeutics for Caplan's Syndrome

Search Clinical Trials , NIH Clinical Center for Caplan's Syndrome

Cochrane evidence based reviews: caplan syndrome

Genetic Tests for Caplan's Syndrome

Anatomical Context for Caplan's Syndrome

MalaCards organs/tissues related to Caplan's Syndrome:

41
Bone, Heart, Eye, T Cells

Publications for Caplan's Syndrome

Articles related to Caplan's Syndrome:

(show all 32)
# Title Authors Year
1
A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. ( 30023036 )
2018
2
Rheumatoid pneumoconiosis (Caplan's syndrome). ( 20493416 )
2010
3
Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation. ( 19820822 )
2009
4
Severe mitral regurgitation in a patient with a bluish right sclera: an 'extension' of Caplan's syndrome to the heart and eye. ( 19237064 )
2009
5
Parkinsonism in Caplan's syndrome. ( 16688603 )
2006
6
Caplan's syndrome. ( 1810363 )
1991
7
Caplan's syndrome. ( 2661027 )
1989
8
HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome. ( 6577907 )
1983
9
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up. ( 483218 )
1979
10
Prevalence of rheumatoid pneumoconiosis (Caplan's syndrome) in metal miners. ( 455199 )
1979
11
HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome. ( 91226 )
1979
12
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis. ( 746502 )
1978
13
Caplan's syndrome in miners. ( 413171 )
1977
14
Pneumoconiosis and Rheumatoid arthritis (Caplan's syndrome). ( 326283 )
1977
15
Rheumatoid pericarditis possibly associated with Caplan's syndrome. ( 1049236 )
1976
16
Caplan's syndrome - a clinical study of 13 cases. ( 1221495 )
1975
17
Caplan's syndrome in association with asbestosis. Report of a case. ( 5161827 )
1971
18
Caplan's syndrome. ( 6081295 )
1967
19
Caplan's syndrome. ( 5937655 )
1966
20
CAPLAN'S SYNDROME IN A SLATE MINER. ( 14114886 )
1964
21
Rheumatoid pneumoconiosis. A case of Caplan's syndrome in a chalk-mine worker. ( 13928349 )
1963
22
A broader concept of Caplan's syndrome related to rheumatoid factors. ( 13876317 )
1962
23
Serum protein changes in Caplan's syndrome. ( 13900595 )
1962
24
Rheumatoid pneumoconiosis (Caplan's syndrome). A discussion of the disease and a report of a case in a European Witwatersrand gold miner. ( 13692590 )
1961
25
Rheumatoid pneumoconiosis (Caplan's syndrome) in an asbestos worker. ( 13920165 )
1961
26
Caplan's syndrome, An interesting clinico-pathological occurrence. ( 14475979 )
1961
27
A case of Caplan's syndrome in a roof tile maker. ( 14400322 )
1960
28
Pneumoconiosis in makers of artificial grinding wheels, including a case of Caplan's syndrome. ( 14434374 )
1960
29
Rheumatoid disease and pneumoconiosis (Caplan's syndrome). ( 13807528 )
1959
30
A case of Caplan's syndrome in a boiler-scaler. ( 13580970 )
1958
31
Caplan's syndrome: a perplexing pneumoconiosis with rheumatoid arthritis. ( 13559659 )
1958
32
Pathological studies of modified pneumoconiosis in coal-miners with rheumatoid arthritis; Caplan's syndrome. ( 14373655 )
1955

Variations for Caplan's Syndrome

Expression for Caplan's Syndrome

Search GEO for disease gene expression data for Caplan's Syndrome.

Pathways for Caplan's Syndrome

GO Terms for Caplan's Syndrome

Cellular components related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 FAS HLA-A TNFRSF10A

Biological processes related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.32 FAS TNFRSF10A
2 cellular response to mechanical stimulus GO:0071260 9.26 FAS TNFRSF10A
3 extrinsic apoptotic signaling pathway GO:0097191 9.16 FAS TNFRSF10A
4 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 8.96 FAS TNFRSF10A
5 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 8.62 TNFRSF10A FAS

Sources for Caplan's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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