MCID: CPL004
MIFTS: 32

Caplan's Syndrome

Categories: Bone diseases, Respiratory diseases

Aliases & Classifications for Caplan's Syndrome

MalaCards integrated aliases for Caplan's Syndrome:

Name: Caplan's Syndrome 12 74 15 17
Caplan Syndrome 12 43 71
Rheumatoid Pneumoconiosis 12
Caplan's Disease 12
Caplans Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10326
MeSH 43 D002205
SNOMED-CT 67 398640008
UMLS 71 C0006915

Summaries for Caplan's Syndrome

Disease Ontology : 12 A pneumoconiosis that results in humans that also have rheumatoid arthritis.

MalaCards based summary : Caplan's Syndrome, also known as caplan syndrome, is related to pneumoconiosis and rheumatoid arthritis. An important gene associated with Caplan's Syndrome is FAS (Fas Cell Surface Death Receptor), and among its related pathways/superpathways are Human T-cell leukemia virus 1 infection and Allograft rejection. Affiliated tissues include lung, eye and heart, and related phenotype is endocrine/exocrine gland.

Wikipedia : 74 Caplan's syndrome (or Caplan disease or rheumatoid pneumoconiosis) is a combination of rheumatoid... more...

Related Diseases for Caplan's Syndrome

Diseases related to Caplan's Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 pneumoconiosis 30.7 MUC5B HLA-DRB1 FAS
2 rheumatoid arthritis 28.7 HLA-DRB1 FOXP3 FAS CD4
3 anthracosis 10.7
4 silicosis 10.5
5 arthritis 10.4
6 asbestosis 10.2
7 asbestos intoxication 10.2
8 stevens-johnson syndrome/toxic epidermal necrolysis 10.2 HLA-A FAS
9 type ii mixed cryoglobulinemia 10.1 HLA-DRB1 FAS
10 hemopericardium 10.1
11 pericardium cancer 10.1
12 renal cell carcinoma, nonpapillary 10.1
13 mitral valve insufficiency 10.1
14 pericarditis 10.1
15 enthesopathy 10.1
16 pulmonary fibrosis 10.1
17 systemic scleroderma 10.1
18 lung disease 10.1
19 vasculitis 10.1
20 postherpetic neuralgia 10.0 HLA-DRB1 HLA-A
21 cytomegalovirus infection 10.0 HLA-A FAS
22 moyamoya angiopathy 10.0 HLA-DRB1 HLA-A
23 nontuberculous mycobacterial lung disease 10.0 HLA-DRB1 HLA-A
24 mental retardation, autosomal dominant 40 10.0 HLA-DRB1 HLA-A
25 idiopathic bronchiectasis 10.0 HLA-DRB1 HLA-A
26 subacute lymphocytic thyroiditis 10.0 FAS CD4
27 pityriasis rosea 10.0 HLA-DRB1 HLA-A
28 guillain-barre syndrome 10.0 HLA-DRB1 FAS
29 red cell aplasia 10.0 HLA-DRB1 HLA-A
30 pars planitis 9.9 HLA-DRB1 HLA-A
31 paraneoplastic pemphigus 9.9 HLA-DRB1 HLA-A
32 alveolar echinococcosis 9.9 HLA-DRB1 HLA-A
33 pure red-cell aplasia 9.9 HLA-DRB1 HLA-A
34 acute myocarditis 9.9 FAS CD4
35 autoimmune neuropathy 9.9 FOXP3 CD4
36 egg allergy 9.9 FOXP3 CD4
37 orchitis 9.9 FOXP3 CD4
38 interstitial pneumonitis, desquamative, familial 9.9 SPPL2C MUC5B ELMOD2
39 legume allergy 9.9 FOXP3 CD4
40 fruit allergy 9.9 FOXP3 CD4
41 filarial elephantiasis 9.9 FOXP3 CD4
42 autoimmune disease of eyes, ear, nose and throat 9.9 FOXP3 CD4
43 t-cell adult acute lymphocytic leukemia 9.8 FOXP3 CD4
44 primary thrombocytopenia 9.8 FOXP3 CD4
45 thrombocytopenia due to platelet alloimmunization 9.8 FOXP3 CD4
46 relapsing-remitting multiple sclerosis 9.8 HLA-DRB1 FOXP3 FAS
47 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.8 FOXP3 CD4
48 cowpox 9.8 FAS CD4
49 anemia, autoimmune hemolytic 9.8 FOXP3 CD4
50 hashimoto thyroiditis 9.8 HLA-DRB1 FOXP3 FAS

Graphical network of the top 20 diseases related to Caplan's Syndrome:



Diseases related to Caplan's Syndrome

Symptoms & Phenotypes for Caplan's Syndrome

MGI Mouse Phenotypes related to Caplan's Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.1 CD4 FAS FOXP3 HLA-A PIWIL2 SPPL2C

Drugs & Therapeutics for Caplan's Syndrome

Search Clinical Trials , NIH Clinical Center for Caplan's Syndrome

Cochrane evidence based reviews: caplan syndrome

Genetic Tests for Caplan's Syndrome

Anatomical Context for Caplan's Syndrome

MalaCards organs/tissues related to Caplan's Syndrome:

40
Lung, Eye, Heart, T Cells

Publications for Caplan's Syndrome

Articles related to Caplan's Syndrome:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Atypical presentation of rheumatoid arthritis: a case of massive bilateral pleural effusions in a patient with Caplan syndrome. 61
31653636 2019
2
A case of Caplan syndrome in a recently diagnosed patient with silicosis: A case report. 61
30023036 2018
3
Erasmus Syndrome: Association of Silicosis and Systemic Sclerosis. 61
29854640 2018
4
[Guideline (S2k, AWMF) of the Deutsche Gesellschaft für Pneumologie und Beatmungsmedizin and the Deutsche Gesellschaft für Arbeitsmedizin und Umweltmedizin "Diagnostics and Expert Opinion in the Occupational Disease No. 4101 Silicosis (Including Coal Worker's Pneumoconiosis)"]. 61
27931056 2016
5
An interesting finding of multiple calcified pulmonary nodules in a patient with rheumatoid arthritis. 61
30364404 2016
6
What to do with all of these lung nodules? 61
24914609 2014
7
[Caplan's syndrome: rarely presenting as <<pulmorenal>> syndrome]. 61
24568764 2014
8
Environmental factors producing autoimmune dysregulation--chronic activation of T cells caused by silica exposure. 61
22226303 2012
9
[Rheumatoid arthritis and interstitial lung alterations - a clear case, isn't it?]. 61
21614765 2011
10
Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients. 61
21329560 2011
11
Rheumatoid pneumoconiosis (Caplan's syndrome). 61
20493416 2010
12
Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation. 61
19820822 2009
13
[Caplan's syndrome in marble workers as occupational disease]. 61
19899255 2009
14
Severe mitral regurgitation in a patient with a bluish right sclera: an 'extension' of Caplan's syndrome to the heart and eye. 61
19237064 2009
15
Immunological effects of silica and asbestos. 61
17764616 2007
16
Parkinsonism in Caplan's syndrome. 61
16688603 2006
17
[New possibilities of making the diagnosis of Caplan syndrome]. 61
17278785 2006
18
[Caplan's syndrome: case report]. 61
16808317 2005
19
[Effects on the lung due to underground coal mining work]. 61
14961440 2004
20
Computed tomography findings of Caplan syndrome. 61
14501367 2003
21
[Caplan's syndrome]. 61
10422515 1998
22
[Changes in the respiratory system of patients with rheumatoid arthritis--personal observations]. 61
9658882 1998
23
[Pleural and pulmonary changes within the scope of rheumatoid arthritis]. 61
8975281 1996
24
Case report: recurrent pneumothorax in a patient with rheumatoid arthritis. 61
8074134 1994
25
[Biventricular inflow tract compression by chronic organized hemopericardium in Caplan syndrome]. 61
7927126 1994
26
[Silicosis and Caplan's syndrome]. 61
8152046 1994
27
[Pleuropulmonary manifestations of rheumatoid arthritis. A casuistic reminder]. 61
8460435 1993
28
Unusual occupational rheumatologic and musculoskeletal disorders. 61
1496427 1992
29
Small airway disease in rheumatoid arthritis. 61
1306077 1992
30
Caplan's syndrome. 61
1810363 1991
31
[A case of Caplan's syndrome in a miner]. 61
2333604 1990
32
[Errors in the evaluation of osteoarticular symptoms]. 61
2800390 1989
33
Caplan's syndrome. 61
2661027 1989
34
Pleuropulmonary necrobiotic rheumatoid nodules. A review and clinicopathological study of six patients. 61
3713605 1986
35
[Structure of rheumatic diseases among the workers of an industrial enterprise (based on epidemiological research data)]. 61
2938299 1986
36
Kaolinosis: a radiological review. 61
4064542 1985
37
[Caplan's syndrome. A case without persistent pneumoconiosis or symptom producing rheumatoid arthritis]. 61
6730051 1984
38
HLA-A, B and DR antigens and properdin factor B allotypes in Caplan's syndrome. 61
6577907 1983
39
HLA-A and B antigen frequencies in Welsh coalworkers with pneumoconiosis and Caplan's syndrome. 61
91226 1979
40
Rheumatoid "pneumoconiosis" (Caplan's syndrome) in an asbestos worker: a 17 years' follow-up. 61
483218 1979
41
Prevalence of rheumatoid pneumoconiosis (Caplan's syndrome) in metal miners. 61
455199 1979
42
Pulmonary function in coal workers with Caplan's syndrome and non-rheumatoid complicated pneumosoniosis. 61
746502 1978
43
[Caplan's syndrome (2 personal cases)]. 61
756257 1977
44
Pneumoconiosis and Rheumatoid arthritis (Caplan's syndrome). 61
326283 1977
45
[Caplan's syndrome in miners (author's transl)]. 61
844061 1977
46
Caplan's syndrome in miners. 61
413171 1977
47
[Caplan's syndrome]. 61
613004 1977
48
Rheumatoid pericarditis possibly associated with Caplan's syndrome. 61
1049236 1976
49
[Caplan's syndrome appearing after 20 years following exposure to silica]. 61
175409 1976
50
[Case of fulminant, HB antigen-associated hepatitis probably caused by blood transfusion during the clinical course of Caplan's syndrome]. 61
1238669 1975

Variations for Caplan's Syndrome

Expression for Caplan's Syndrome

Search GEO for disease gene expression data for Caplan's Syndrome.

Pathways for Caplan's Syndrome

Pathways related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 HLA-DRB1 HLA-A CD4
2
Show member pathways
11.76 HLA-DRB1 HLA-A FOXP3 FAS CD4
3 11.6 HLA-DRB1 HLA-A CD4
4
Show member pathways
11.39 HLA-DRB1 CD4
5
Show member pathways
11.38 HLA-DRB1 HLA-A CD4
6
Show member pathways
11.17 HLA-DRB1 HLA-A CD4
7 11.14 FOXP3 CD4
8
Show member pathways
11.01 FOXP3 FAS
9 10.83 HLA-DRB1 CD4
10 10.77 HLA-DRB1 CD4

GO Terms for Caplan's Syndrome

Cellular components related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 HLA-DRB1 HLA-A FAS CD4
2 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.8 SPPL2C HLA-DRB1 HLA-A

Biological processes related to Caplan's Syndrome according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.62 HLA-DRB1 HLA-A FAS CD4
2 positive regulation of protein phosphorylation GO:0001934 9.58 HLA-DRB1 FAS CD4
3 T cell activation GO:0042110 9.51 FOXP3 CD4
4 negative regulation of T cell proliferation GO:0042130 9.49 HLA-DRB1 FOXP3
5 antigen processing and presentation GO:0019882 9.48 HLA-DRB1 HLA-A
6 cytokine production GO:0001816 9.46 FOXP3 CD4
7 negative regulation of interferon-gamma production GO:0032689 9.43 HLA-DRB1 FOXP3
8 macrophage differentiation GO:0030225 9.37 HLA-DRB1 CD4
9 detection of bacterium GO:0016045 9.26 HLA-DRB1 HLA-A
10 positive regulation of monocyte differentiation GO:0045657 9.16 HLA-DRB1 CD4
11 positive regulation of viral entry into host cell GO:0046598 8.96 HLA-DRB1 CD4
12 T cell receptor signaling pathway GO:0050852 8.92 HLA-DRB1 HLA-A FOXP3 CD4

Molecular functions related to Caplan's Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.62 HLA-DRB1 HLA-A

Sources for Caplan's Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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