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MCID: CRB016
MIFTS: 39

Carbuncle

Categories: Eye diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Carbuncle

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MalaCards integrated aliases for Carbuncle:

Name: Carbuncle 12 15 17 71
Carbuncle and Furuncle of Any Part of Face Except Eye 12
Carbuncle and Furuncle of Upper Arm and Forearm 12
Carbuncle and Furuncle of Leg Except Foot 12
Carbuncle and Furuncle of Gluteal Region 12
Carbuncle and Furuncle of Buttock 12
Carbuncle and Furuncle of Trunk 12
Carbuncle and Furuncle of Face 12
Carbuncle and Furuncle of Foot 12
Carbuncle and Furuncle of Hand 12
Carbuncle and Furuncle of Neck 12

Classifications:

MalaCards categories:
Anatomical: Skin diseases Eye diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2176
ICD9CM 34 680.9
UMLS 71 C0007078 C0007079
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Summaries for Carbuncle

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MalaCards based summary : Carbuncle, also known as carbuncle and furuncle of any part of face except eye, is related to pyelonephritis and peritonitis. An important gene associated with Carbuncle is MT-TH (Mitochondrially Encoded TRNA-His (CAU/C)), and among its related pathways/superpathways are PAK Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs Anti-Infective Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, eye and skin, and related phenotype is hematopoietic system.

Wikipedia : 74 A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus... more...

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Related Diseases for Carbuncle

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Diseases related to Carbuncle via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 401)
# Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.1 TNF IL6 IL1B
2 peritonitis 30.0 TNF IL6 IL1B
3 erysipelas 29.9 TNF IL6 IL1B
4 osteomyelitis 29.9 TNF IL6 IL1B
5 appendicitis 29.9 TNF IL6 IL1B
6 acute cystitis 29.9 TNF IL6 IL1B
7 staphylococcal toxic shock syndrome 10.3 TNF IL1B
8 vulvar vestibulitis syndrome 10.3 TNF IL1B
9 palladium allergic contact dermatitis 10.3 TNF IL1B
10 kashin-beck disease 10.3 TNF IL1B
11 discitis 10.3 TXNDC12 TST
12 arachnoiditis 10.3 TNF IL1B
13 cerebritis 10.3 TNF IL1B
14 actinic prurigo 10.3 TNF IL1B
15 congenital cytomegalovirus 10.2 TNF IL1B
16 external pathological resorption 10.2 TNF IL6
17 pemphigoid 10.2 TNF IL1B
18 chemical colitis 10.2 TNF IL1B
19 enterocolitis 10.2 TNF IL6
20 scorpion envenomation 10.2 TNF IL6
21 palindromic rheumatism 10.2 TNF IL1B
22 prosthetic joint infection 10.2 IL6 IL1B
23 dental pulp necrosis 10.2 TNF IL1B
24 periodontitis, chronic 10.2 IL6 IL1B
25 idiopathic anterior uveitis 10.2 TNF IL6
26 streptococcal toxic-shock syndrome 10.2 TNF IL6
27 anthrax disease 10.2
28 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 TNF IL6
29 ritter's disease 10.2 TST SCIN
30 pneumonic tularemia 10.2 TNF IL1B
31 uremic pruritus 10.2 IL6 IL1B
32 indolent plasma cell myeloma 10.2 IL6 IL1B
33 cardiogenic shock 10.2 TNF IL6
34 back pain 10.2 IL6 IL1B
35 anaerobic pneumonia 10.2 IL6 IL1B
36 transient arthritis 10.2 IL6 IL1B
37 null-cell leukemia 10.2 TNF IL6
38 shigellosis 10.2 TNF NFKBIA IL1B
39 systemic onset juvenile idiopathic arthritis 10.2 TNF IL6
40 glomeruloid hemangioma 10.2 IL6 IL1B
41 suppurative periapical periodontitis 10.2 IL6 IL1B
42 posterior urethral valves 10.1 TNF IL6
43 tungiasis 10.1 TNF IL1B
44 diabetic encephalopathy 10.1 IL1B CASP3
45 newcastle disease 10.1 TNF NFKBIA CASP3
46 post-transplant lymphoproliferative disease 10.1 TNF IL6
47 superficial basal cell carcinoma 10.1 TNF IL6
48 coronary aneurysm 10.1 TNF IL6
49 lymphadenitis 10.1 TNF IL1B CASP3
50 chondromalacia 10.1 TNF IL6

Graphical network of the top 20 diseases related to Carbuncle:



Diseases related to Carbuncle
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Symptoms & Phenotypes for Carbuncle

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MGI Mouse Phenotypes related to Carbuncle:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.32 ACHE ACTB CASP3 CYCS IL1B IL6
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Drugs & Therapeutics for Carbuncle

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Drugs for Carbuncle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Early Phase 1
2 Anti-Bacterial Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Wound Packing Following Incision and Drainage of Superficial Skin Abscesses in the Pediatric Emergency Department Completed NCT00746109 Phase 4
2 The Treatment Effect of Chinese Medicine Formula on Uremic Pruritus Not yet recruiting NCT04650750 Early Phase 1 Xiao-Feng-San+Shian-Fang-Hwa-Ming-Yiin;Placebo

Search NIH Clinical Center for Carbuncle

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Genetic Tests for Carbuncle

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Anatomical Context for Carbuncle

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MalaCards organs/tissues related to Carbuncle:

40
Kidney, Eye, Skin, Breast, Colon, Myeloid
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Publications for Carbuncle

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Articles related to Carbuncle:

(show top 50) (show all 296)
# Title Authors PMID Year
1
Integrated strategy of LC-MS and network pharmacology for predicting active constituents and pharmacological mechanisms of Ranunculus japonicus Thunb. for treating rheumatoid arthritis. 61
33465444 2021
2
Medical conditions of Omer Seyfettin (1884-1920), the father of Turkish short stories, enshrined as a mystery. 61
32924736 2020
3
Buttock carbuncle with severe hypothermia and disturbed consciousness: When os odontoideum is the answer. 61
32526484 2020
4
Multiscale kinetic inviscid flux extracted from a gas-kinetic scheme for simulating incompressible and compressible flows. 61
33075992 2020
5
Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. 61
32446927 2020
6
[VSD technique combined with Bing Shi Yu Shang Ointment for the treatment of foot skin defects]. 61
32959578 2020
7
Severe bacterial skin infections. 61
32507327 2020
8
Satisfactory response of a back carbuncle to 5-aminolevulinic acid (ALA) photodynamic therapy: A case report. 61
31841685 2020
9
[Study on literature of Echinacea purpurea and discussion on its herbalization]. 61
32237435 2020
10
Ethanol extract of Elephantopus scaber Linn. Attenuates inflammatory response via the inhibition of NF-κB signaling by dampening p65-DNA binding activity in lipopolysaccharide-activated macrophages. 61
31877363 2020
11
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 61
32049716 2020
12
Traditional uses, phytochemistry, and pharmacology of Persicaria orientalis (L.) Spach - A review. 61
31751652 2020
13
Effect of Lonicerae japonicae Flos Carbonisata-Derived Carbon Dots on Rat Models of Fever and Hypothermia Induced by Lipopolysaccharide. 61
32606669 2020
14
[Bilateral acute purulent destructive pyelonephritis after retrograde ureteroscopy and lithotripsy]. 61
31808644 2019
15
β-Caryophyllene in the Essential Oil from Chrysanthemum Boreale Induces G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells. 61
31635244 2019
16
The first complete chloroplast genome of Liparis nervosa and its phylogenetic position within Orchidaceae. 61
33366174 2019
17
Development of multicomponent lattice Boltzmann flux solver for simulation of compressible viscous reacting flows. 61
31639947 2019
18
Pharmacognostical study of Desmodium caudatum. 61
31241702 2019
19
Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells. 61
29921888 2019
20
A review of the ethnopharmacology, phytochemistry, and pharmacology of Changium smyrnioides Wolff. 61
30182179 2019
21
[Systematic review and comment on modern study of Xiaojin Pills]. 61
30717523 2018
22
[Application of delayed skin-stretching device in treatment of skin and soft tissue defects]. 61
30215495 2018
23
Neck carbuncle associated with methicillin-susceptible Staphylococcus aureus bacteraemia. 61
30366898 2018
24
[Anti-inflammatory mechanism of heat-clearing and detoxifying Chinese herbs]. 61
30384547 2018
25
The chemistry and pharmacology of Ligularia przewalskii: A review. 61
29526703 2018
26
Deep Neck Space Infections-A Study in Diabetic Population in a Tertiary Care Centre. 61
29456938 2018
27
Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. 61
28887216 2018
28
Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine. 61
29433390 2018
29
Pressure- and dose-controlled transcutaneous pneumatic injection of hypertonic glucose solution for the treatment of atrophic skin disorders. 61
28665146 2017
30
Influence of low-level laser on pain and inflammation in type 2 diabetes mellitus with diabetic dermopathy - A case report. 61
28494177 2017
31
Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution. 61
28412984 2017
32
'Carbuncle in diabetes': a problem even today! 61
28630227 2017
33
An Unusually Large Carbuncle of the Temporofacial Region Demonstrating Remarkable Post-debridement Wound Healing Process: A Case Report. 61
28448262 2017
34
Carbuncle due to Salmonella Enteritidis: a novel presentation. 61
28912837 2017
35
Uncommon Odontogenic Orocutaneous Fistula of the Jaw Treated with Platelet-Rich Fibrin. 61
28458932 2017
36
Bioactive alkaloids from the aerial parts of Houttuynia cordata. 61
27840258 2017
37
The Genus Patrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies. 61
28595500 2017
38
Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. 61
27082059 2016
39
Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice. 61
27023331 2016
40
Anti-inflammatory effects, nuclear magnetic resonance identification, and high-performance liquid chromatography isolation of the total flavonoids from Artemisia frigida. 61
28911593 2016
41
Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child. 61
26868410 2016
42
Gleditsia species: An ethnomedical, phytochemical and pharmacological review. 61
26643065 2016
43
Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings. 61
26520575 2015
44
Myeloid Sarcoma Masquerading as Granulation Tissue: A Diagnostic Pitfall. 61
26063639 2015
45
Who leaves the hospital against medical advice in the orthopaedic setting? 61
25187333 2015
46
Forehead carbuncle with intractable headache. 61
25848276 2015
47
[Renal carbuncle and perirenal abscess in children and adolescents]. 61
25190305 2014
48
Infection of the Beard area. Kerion: a review of 2 cases. 61
25226722 2014
49
Study on anti-osteosarcoma activity of ethanol extract of Venenum bufonis in vitro. 61
24653556 2014
50
Excision of carbuncle with primary split-thickness skin grafting as a new treatment modality. 61
22883561 2013
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Variations for Carbuncle

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Expression for Carbuncle

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Search GEO for disease gene expression data for Carbuncle.
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Pathways for Carbuncle

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Pathways related to Carbuncle according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 63
Show member pathways
 13.25 TNF NFKBIA IL6 IL1B CASP3 ACTB
2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 65
Show member pathways
 13.24 TNF IL6 IL1B CYCS CASP3 ACTB
3
TNFR1 Pathway 63
Show member pathways
 13.03 TNF NFKBIA IL6 CYCS CASP3 ACTB
4
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 13 TNF NFKBIA IL6 IL1B CYCS CASP3
5
Human cytomegalovirus infection 36
Show member pathways
 12.84 TNF NFKBIA IL6 IL1B CYCS CASP3
6
Prion disease 36
Show member pathways
 12.8 TNF IL6 IL1B CYCS CASP3
7
Allograft rejection 36 1
Show member pathways
 12.74 TNF IL6 IL1B CYCS CASP3 ACTB
8
Apoptosis Modulation and Signaling 1
Show member pathways
 12.68 TNF NFKBIA CYCS CASP3 ACTB
9
Herpes simplex virus 1 infection 36
12.67 TNF NFKBIA IL6 IL1B CYCS CASP3
10
nNOS Signaling in Skeletal Muscle 63
Show member pathways
 12.63 TNF CYCS CASP3 ACTB
11
4-1BB Pathway 63
Show member pathways
 12.63 TNF NFKBIA IL1B CASP3
12
T cell receptor signaling pathway 36
Show member pathways
 12.57 TNF NFKBIA IL6 IL1B
13
Th17 cell differentiation 36
Show member pathways
 12.56 TNF NFKBIA IL6 IL1B
14
Immune response IL-23 signaling pathway 23
Show member pathways
 12.55 TNF NFKBIA IL6 IL1B
15
TRAF Pathway 63
Show member pathways
 12.51 TNF NFKBIA IL1B CYCS CASP3
16
Measles 36
Show member pathways
 12.51 TNF NFKBIA IL6 IL1B CYCS CASP3
17
Toll Comparative Pathway 63
Show member pathways
 12.3 TNF NFKBIA IL6 IL1B
18
Shigellosis 36
12.3 TNF NFKBIA IL1B CYCS ACTB
19
NOD-like receptor signaling pathway 36
12.22 TNF NFKBIA IL6 IL1B
20
IL-17 Family Signaling Pathways 64
Show member pathways
 12.21 TNF NFKBIA IL6 IL1B CASP3
21
C-type lectin receptor signaling pathway 36
Show member pathways
 12.19 TNF NFKBIA IL6 IL1B
22
Apoptosis and survival Caspase cascade 23
Show member pathways
 12.17 TNF CYCS CASP3 ACTB
23
Bacterial infections in CF airways 23
Show member pathways
 12.15 TNF NFKBIA IL6 IL1B
24
Salmonella infection (KEGG) 36
Show member pathways
 12.15 TNF NFKBIA IL6 IL1B CYCS CASP3
25
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
12.14 TNF IL6 IL1B CASP3
26
Toxoplasmosis 36
Show member pathways
 12.11 TNF NFKBIA IL1B CYCS CASP3
27
Alzheimers Disease 1
12.09 TNF IL1B CYCS CASP3
28
Osteoclast differentiation 36
12.02 TNF NFKBIA IL1B
29
Tuberculosis 36
12.02 TNF IL6 IL1B CYCS CASP3
30
Ceramide Pathway 63
Show member pathways
 12 TNF CYCS CASP3
31
Interleukin-4 and 13 signaling 65
11.96 TNF IL6 IL1B
32
Insulin resistance 36
Show member pathways
 11.94 TNF NFKBIA IL6
33
Spinal Cord Injury 1
11.94 TNF IL6 IL1B CASP3
34
NF-kappa B signaling pathway 36
11.91 TNF NFKBIA IL1B
35
Hematopoietic cell lineage 36
11.88 TNF IL6 IL1B
36
Amoebiasis 36
11.86 TNF IL6 IL1B CASP3
37
Yersinia infection 36
11.86 TNF NFKBIA IL6 IL1B ACTB
38
Rheumatoid arthritis 36
11.85 TNF IL6 IL1B
39
Small cell lung cancer 36
11.84 NFKBIA CYCS CASP3
40
AGE-RAGE signaling pathway in diabetic complications 36
11.84 TNF IL6 IL1B CASP3
41
LT-BetaR Pathway 63
Show member pathways
 11.8 NFKBIA CYCS CASP3
42
Th1 Differentiation Pathway 64
Show member pathways
 11.75 TNF IL6 IL1B
43
Dendritic Cells Developmental Lineage Pathway 64
11.74 TNF IL6 IL1B
44
AGE/RAGE pathway 1
11.69 NFKBIA CYCS CASP3
45
LPA receptor mediated events 1
11.68 NFKBIA IL6 CASP3
46
Lung fibrosis 1
11.66 TNF IL6 IL1B
47
Pertussis 36
11.64 TNF IL6 IL1B CASP3
48
TNF signaling pathway 36
11.6 TNF NFKBIA IL6 IL1B CASP3
49
Malaria 36
11.55 TNF IL6 IL1B
50
Interleukin-10 signaling 65
11.54 TNF IL6 IL1B
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GO Terms for Carbuncle

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Biological processes related to Carbuncle according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.91 TNF SCIN IL6 CASP3
2 cytokine-mediated signaling pathway GO:0019221 9.86 TNF IL6 IL1B CASP3
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.75 TNF IL6 IL1B
4 positive regulation of inflammatory response GO:0050729 9.74 TNF NFKBIA IL1B
5 positive regulation of interleukin-6 production GO:0032755 9.72 TNF IL6 IL1B
6 regulation of insulin secretion GO:0050796 9.7 TNF IL6 IL1B
7 cellular response to organic cyclic compound GO:0071407 9.69 TNF IL1B CASP3
8 response to glucocorticoid GO:0051384 9.67 TNF IL6 CASP3
9 positive regulation of interleukin-8 production GO:0032757 9.65 TNF IL6 IL1B
10 negative regulation of lipid catabolic process GO:0050995 9.61 TNF IL1B
11 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.6 TNF IL1B
12 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.59 TNF IL1B
13 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.58 TNF IL6
14 regulation of establishment of endothelial barrier GO:1903140 9.54 TNF IL1B
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TNF NFKBIA IL1B
16 negative regulation of neurogenesis GO:0050768 9.5 TNF IL6 IL1B
17 positive regulation of fever generation GO:0031622 9.46 TNF IL1B
18 sequestering of triglyceride GO:0030730 9.43 TNF IL1B
19 positive regulation of glial cell proliferation GO:0060252 9.43 TNF IL6 IL1B
20 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.4 TNF IL1B
21 positive regulation of neuroinflammatory response GO:0150078 9.33 TNF IL6 IL1B
22 negative regulation of lipid storage GO:0010888 9.13 TNF NFKBIA IL6
23 vascular endothelial growth factor production GO:0010573 8.8 TNF IL6 IL1B
Sources

Sources for Carbuncle

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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