Aliases & Classifications for Carbuncle

MalaCards integrated aliases for Carbuncle:

Name: Carbuncle 12 15 73
Carbuncle and Furuncle of Any Part of Face Except Eye 12
Carbuncle and Furuncle of Upper Arm and Forearm 12
Carbuncle and Furuncle of Leg Except Foot 12
Carbuncle and Furuncle of Gluteal Region 12
Carbuncle and Furuncle of Buttock 12
Carbuncle and Furuncle of Trunk 12
Carbuncle and Furuncle of Face 12
Carbuncle and Furuncle of Foot 12
Carbuncle and Furuncle of Hand 12
Carbuncle and Furuncle of Neck 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2176
ICD9CM 35 680.9

Summaries for Carbuncle

MalaCards based summary : Carbuncle, also known as carbuncle and furuncle of any part of face except eye, is related to lung cancer and griscelli syndrome, type 1. An important gene associated with Carbuncle is SPAG1 (Sperm Associated Antigen 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and kidney, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus... more...

Related Diseases for Carbuncle

Graphical network of the top 20 diseases related to Carbuncle:



Diseases related to Carbuncle

Symptoms & Phenotypes for Carbuncle

GenomeRNAi Phenotypes related to Carbuncle according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 10.06 CDK2 MAPK3
2 Decreased substrate adherent cell growth GR00193-A-2 10.06 CDK2 CDK4 MAPK14 MAPK3
3 Decreased substrate adherent cell growth GR00193-A-3 10.06 CDK2 CDK4 MAPK3
4 Decreased substrate adherent cell growth GR00193-A-4 10.06 CDK2 CDK4
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.83 MAPK8 CDK2 MPO NFKBIA BAX MAPK3
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.83 MAPK8 CDK2 MPO NFKBIA BAX MAPK3
7 Decreased viability with paclitaxel GR00179-A-1 9.55 BCL2L1 MAPK3
8 Decreased viability with paclitaxel GR00179-A-2 9.55 BCL2L1
9 Decreased viability with paclitaxel GR00179-A-3 9.55 BCL2L1 MAPK3
10 Decreased telomerase activity GR00156-A 9.43 MAPK8 MAPK14 MAPK3
11 Increased cell viability after pRB stimulation GR00230-A-1 9.26 MAPK8 CDK2 CDK4 MAPK14

MGI Mouse Phenotypes related to Carbuncle:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.32 CYCS MAPK14 FGF2 LYZ MAPK3 CDK4
2 cellular MP:0005384 10.3 LYZ CYCS MAPK14 FGF2 BCL2L1 CDK4
3 homeostasis/metabolism MP:0005376 10.3 LYZ MAPK14 FGF2 BCL2L1 CDK4 BAX
4 endocrine/exocrine gland MP:0005379 10.29 MAPK3 CYCS MAPK14 LYZ BCL2L1 CDK4
5 cardiovascular system MP:0005385 10.28 LYZ CYCS MAPK14 FGF2 CDK4 CASP9
6 growth/size/body region MP:0005378 10.27 LYZ CYCS MAPK14 BCL2L1 CDK4 CASP9
7 behavior/neurological MP:0005386 10.25 CDK4 LYZ CYCS FGF2 MAPK14 BCL2L1
8 immune system MP:0005387 10.25 LYZ CYCS MAPK14 BCL2L1 CDK4 CASP9
9 mortality/aging MP:0010768 10.21 LYZ CYCS MAPK14 FGF2 BCL2L1 CDK4
10 integument MP:0010771 10.01 LYZ MAPK14 CDK2 BCL2L1 CDK4 MAPK3
11 neoplasm MP:0002006 9.96 MAPK14 FGF2 LYZ MAPK3 CDK4 BAX
12 muscle MP:0005369 9.92 MAPK14 FGF2 CDK4 BAX CDK2 MPO
13 nervous system MP:0003631 9.85 CDK4 LYZ CYCS FGF2 MAPK14 BCL2L1
14 reproductive system MP:0005389 9.56 CDK4 LYZ FGF2 MAPK14 CDK2 BCL2L1
15 skeleton MP:0005390 9.23 LYZ CYCS FGF2 MAPK14 BAX MAPK3

Drugs & Therapeutics for Carbuncle

Drugs for Carbuncle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4 7553-56-2 807
2
Povidone Approved Phase 4 9003-39-8
3
Povidone-iodine Approved Phase 4 25655-41-8
4 Anti-Infective Agents Phase 4,Not Applicable
5 Anti-Infective Agents, Local Phase 4
6 Blood Substitutes Phase 4
7 cadexomer iodine Phase 4
8 Plasma Substitutes Phase 4
9
Cephalexin Approved, Investigational, Vet_approved Not Applicable 15686-71-2 27447
10
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
11
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
12
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
13
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
14
leucovorin Approved, Nutraceutical Not Applicable 58-05-9 143 6006
15 Anti-Bacterial Agents ,Not Applicable
16 methicillin ,Not Applicable
17 Antibiotics, Antitubercular Not Applicable
18 Antimalarials Not Applicable
19 Antiparasitic Agents Not Applicable
20 Antiprotozoal Agents Not Applicable
21 Clindamycin palmitate Not Applicable
22 Clindamycin phosphate Not Applicable
23 Cytochrome P-450 Enzyme Inhibitors Not Applicable
24 Folic Acid Antagonists Not Applicable
25 Renal Agents Not Applicable
26 Vitamin B Complex Not Applicable
27 Folate Nutraceutical Not Applicable
28 Vitamin B9 Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Skin and Soft Tissue Infection (SSTI) Study Completed NCT02600871 Phase 4 Provodine
2 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
3 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
4 Effective Antibiotic Treatment of MRSA Completed NCT00388310 Not Applicable

Search NIH Clinical Center for Carbuncle

Genetic Tests for Carbuncle

Anatomical Context for Carbuncle

MalaCards organs/tissues related to Carbuncle:

41
Eye, Skin, Kidney, Colon, Lung

Publications for Carbuncle

Articles related to Carbuncle:

(show top 50) (show all 77)
# Title Authors Year
1
An Unusually Large Carbuncle of the Temporofacial Region Demonstrating Remarkable Post-debridement Wound Healing Process: A Case Report. ( 28448262 )
2017
2
Carbuncle due to Salmonella Enteritidis: a novel presentation. ( 28912837 )
2017
3
Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution. ( 28412984 )
2017
4
'Carbuncle in diabetes': a problem even today! ( 28630227 )
2017
5
Forehead carbuncle with intractable headache. ( 25848276 )
2015
6
Granulicatella adiacens--an unusual causative agent for carbuncle. ( 23455831 )
2012
7
Excision of carbuncle with primary split thickness skin grafting as a new treatment modality. ( 22883561 )
2012
8
Kidney metastasis of lung cancer presenting as renal carbuncle. ( 10368265 )
1999
9
The valgus and the carbuncle. ( 27517372 )
1999
10
A polypous carbuncle. ( 9585897 )
1998
11
Picture of the month. Folliculitis, furunculosis, and carbuncles. ( 9193252 )
1997
12
A case of carbuncle caused by a catalase-negative strain of staphylococcus aureus. ( 8831037 )
1996
13
Case study: carbuncle of the neck with extensive tunnelling. ( 8489687 )
1993
14
Renal carbuncle presenting as acute peritonitis in pregnancy. ( 1884151 )
1991
15
Carbuncle--a conservative approach. ( 3681747 )
1987
16
Oral antibiotics and the renal carbuncle. ( 3775488 )
1986
17
Conservative approach in treating acute renal carbuncle. ( 3884550 )
1985
18
Renal carbuncle: comparison between surgical open drainage and closed percutaneous drainage. ( 3881871 )
1985
19
Renal carbuncle: diagnosis and management. ( 7222317 )
1981
20
A case of renal carbuncle-the role of radionuclides. ( 7388292 )
1980
21
Management of renal carbuncle. ( 671594 )
1978
22
Renal carbuncle in a neonate with congenital nephrotic syndrome. ( 349130 )
1978
23
A case of renal carbuncle. ( 388281 )
1978
24
Renal carbuncle: the use of ultrasound in its diagnosis and treatment. ( 916041 )
1977
25
Antibiotic treatment of renal carbuncle. ( 900675 )
1977
26
Acute renal carbuncle. ( 926263 )
1977
27
Renal carbuncle: simulation of tumor response to epinephrine. ( 601943 )
1977
28
Renal carbuncle: unusual cause of postpartum febrile morbidity. ( 943542 )
1976
29
Renal carbuncle: early diagnosis by retroperitoneal ultrasound. ( 1246759 )
1976
30
Diabetic carbuncle. ( 1075009 )
1975
31
Acute renal carbuncle: the importance of preoperative angiography. ( 4830871 )
1974
32
Carbuncle: discussion and a report of two cases. ( 4207521 )
1974
33
Renal carbuncle. ( 4723824 )
1973
34
Renal carbuncle. ( 4717842 )
1973
35
Renal carbuncle: antibiotic therapy governed by ultrasonically guided aspiration. ( 4699670 )
1973
36
Acute renal carbuncle. The roentgenographic clarification of a medical enigma. ( 4566089 )
1972
37
Segmental acute pyelonephritis. A precursor to renal carbuncle or abscess? ( 5070143 )
1972
38
Arteriography and antibiotic therapy of a renal carbuncle. ( 5014349 )
1972
39
The roentgen features of renal carbuncle. ( 5082732 )
1972
40
[Renal carbuncle with xanthogranulomatous change: report of a case]. ( 5465187 )
1970
41
How I treat furuncles, carbuncles and impetigo. ( 6044109 )
1967
42
Carbuncle of the kidney. ( 5943895 )
1966
43
MALIGNANT MELANOMA DEVELOPING IN A URETHRAL CARBUNCLE. ( 14204613 )
1964
44
Renal carbuncle with perforation into the peritoneal cavity. ( 13760235 )
1960
45
Boils, carbuncles and impetigo. ( 13844889 )
1960
46
Renal carbuncle; report of a response to modern treatment. ( 13452010 )
1957
47
Carbuncle of the kidney. ( 13230543 )
1955
48
Chronic renal carbuncle with gross fibrous reaction. ( 13280695 )
1955
49
Renal carbuncle. ( 13125928 )
1953
50
Carbuncle caused by Gaffkya tetragena treated with oxytetracycline (terramycin). ( 13091374 )
1953

Variations for Carbuncle

Expression for Carbuncle

Search GEO for disease gene expression data for Carbuncle.

Pathways for Carbuncle

Pathways related to Carbuncle according to GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 BAX BCL2L1 CASP9 CYCS FGF2 MAPK14
2
Show member pathways
13.94 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3
Show member pathways
13.39 BAX CASP9 FGF2 MAPK3 MAPK8 NFKBIA
4
Show member pathways
13.22 CDK2 CDK4 CYCS MAPK14 MAPK3 MAPK8
5
Show member pathways
13.07 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
6
Show member pathways
13.02 CASP9 CYCS MAPK14 MAPK3 MAPK8 NFKBIA
7
Show member pathways
12.94 CASP9 MAPK14 MAPK3 MAPK8 NFKBIA
8
Show member pathways
12.91 BAX BCL2L1 CASP9 CYCS MAPK3 MAPK8
9
Show member pathways
12.91 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
10
Show member pathways
12.9 BAX CYCS MAPK14 MAPK3 MAPK8 NFKBIA
11
Show member pathways
12.88 CASP9 CDK2 CDK4 CYCS MAPK14 MAPK3
12
Show member pathways
12.87 BAX BCL2L1 CDK2 CDK4 FGF2 MAPK3
13 12.86 CASP9 FGF2 MAPK14 MAPK3 MAPK8
14
Show member pathways
12.82 BCL2L1 FGF2 MAPK14 MAPK3 MAPK8
15
Show member pathways
12.81 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
16
Show member pathways
12.79 BAX CASP9 CDK2 CDK4 CYCS MAPK14
17
Show member pathways
12.78 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
18
Show member pathways
12.77 CASP9 CYCS MAPK14 MAPK3 MAPK8 NFKBIA
19
Show member pathways
12.7 BCL2L1 CASP9 MAPK14 MAPK3 MAPK8 NFKBIA
20
Show member pathways
12.69 BAX BCL2L1 CASP9 CYCS MAPK3 MAPK8
21
Show member pathways
12.69 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
22 12.68 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
23
Show member pathways
12.61 CASP9 CYCS MAPK14 MAPK3 MAPK8
24
Show member pathways
12.61 CASP9 CYCS MAPK14 MAPK3 MAPK8 NFKBIA
25
Show member pathways
12.59 CASP9 MAPK3 MAPK8 NFKBIA
26
Show member pathways
12.58 MAPK14 MAPK3 MAPK8 PTPN1
27
Show member pathways
12.58 BAX BCL2L1 MAPK14 MAPK3 MAPK8 NFKBIA
28
Show member pathways
12.56 BCL2L1 FGF2 MAPK14 MAPK3 MAPK8 NFKBIA
29
Show member pathways
12.55 BAX BCL2L1 CASP9 MAPK14 MAPK8 NFKBIA
30
Show member pathways
12.54 CDK4 MAPK14 MAPK3 MAPK8 NFKBIA
31
Show member pathways
12.53 BCL2L1 MAPK14 MAPK3 MAPK8 NFKBIA
32 12.53 BAX BCL2L1 CDK4 MAPK8 NFKBIA
33
Show member pathways
12.52 MAPK14 MAPK3 MAPK8 NFKBIA
34
Show member pathways
12.52 BCL2L1 MAPK14 MAPK3 NFKBIA
35
Show member pathways
12.52 CASP9 MAPK14 MAPK3 MAPK8 NFKBIA
36
Show member pathways
12.51 BAX BCL2L1 CASP9 FGF2 MAPK14 MAPK3
37
Show member pathways
12.48 CASP9 MAPK14 MAPK3 NFKBIA
38
Show member pathways
12.48 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
39
Show member pathways
12.47 MAPK14 MAPK3 MAPK8 NFKBIA
40
Show member pathways
12.44 CDK2 MAPK14 MAPK3 MAPK8
41
Show member pathways
12.44 BCL2L1 MAPK14 MAPK3 MAPK8 NFKBIA
42
Show member pathways
12.42 MAPK14 MAPK3 MAPK8 NFKBIA
43 12.41 CDK2 MAPK14 MAPK8 NFKBIA SPN
44 12.41 BAX CDK2 CDK4 MAPK3 NFKBIA
45
Show member pathways
12.4 MAPK14 MAPK3 MAPK8 NFKBIA
46
Show member pathways
12.39 CASP9 MAPK14 MAPK3 MAPK8
47
Show member pathways
12.37 MAPK14 MAPK3 MAPK8 NFKBIA
48 12.35 BAX BCL2L1 CASP9 CYCS
49 12.35 BAX CASP9 CYCS MAPK14 MAPK3 MAPK8
50
Show member pathways
12.35 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK14

GO Terms for Carbuncle

Cellular components related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.56 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
2 cytosol GO:0005829 9.44 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3 Bcl-2 family protein complex GO:0097136 9.16 BAX BCL2L1
4 cytoplasm GO:0005737 10.13 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK14
5 nucleus GO:0005634 10.07 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS

Biological processes related to Carbuncle according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.97 BAX CASP9 CDK2 MAPK14 MAPK3
2 apoptotic process GO:0006915 9.91 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
3 positive regulation of apoptotic process GO:0043065 9.88 BAX BCL2L1 CASP9 CDK4 MAPK8
4 response to toxic substance GO:0009636 9.8 BAX CDK4 MAPK3
5 peptidyl-serine phosphorylation GO:0018105 9.8 CDK2 MAPK14 MAPK3 MAPK8
6 Ras protein signal transduction GO:0007265 9.75 CDK2 FGF2 MAPK14
7 response to lipopolysaccharide GO:0032496 9.72 CASP9 MAPK14 MAPK3 MPO NFKBIA
8 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.7 BAX BCL2L1 CASP9
9 response to muscle stretch GO:0035994 9.63 MAPK14 NFKBIA
10 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.63 BAX BCL2L1 CASP9
11 regulation of ossification GO:0030278 9.62 MAPK14 MAPK3
12 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.61 MAPK3 PTPN1
13 response to muramyl dipeptide GO:0032495 9.61 MAPK14 NFKBIA
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 MAPK14 MAPK3 NFKBIA
15 positive regulation of macrophage chemotaxis GO:0010759 9.6 MAPK14 MAPK3
16 signal transduction in response to DNA damage GO:0042770 9.59 CASP9 MAPK14
17 regulation of insulin receptor signaling pathway GO:0046626 9.58 CDK4 PTPN1
18 regulation of DNA binding transcription factor activity GO:0051090 9.58 MAPK14 MAPK3 MAPK8
19 obsolete activation of signaling protein activity involved in unfolded protein response GO:0006987 9.56 BAX PTPN1
20 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.55 BAX PTPN1
21 positive regulation of cytokine secretion involved in immune response GO:0002741 9.54 MAPK14 MAPK3
22 positive regulation of metallopeptidase activity GO:1905050 9.51 MAPK14 MAPK3
23 cellular response to organic substance GO:0071310 9.46 BAX MAPK14 MAPK3 MAPK8
24 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 9.43 BAX CASP9 CYCS
25 regulation of gene expression GO:0010468 9.43 CDK2 CDK4 MAPK14 MAPK3 MAPK8 NFKBIA
26 positive regulation of cyclase activity GO:0031281 8.8 MAPK14 MAPK3 MAPK8
27 protein phosphorylation GO:0006468 10.03 CDK2 CDK4 MAPK14 MAPK3 MAPK8

Molecular functions related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.72 CDK2 CDK4 MAPK14 MAPK3 MAPK8
2 protein serine/threonine kinase activity GO:0004674 9.65 CDK2 CDK4 MAPK14 MAPK3 MAPK8
3 nucleotide binding GO:0000166 9.55 CDK2 CDK4 MAPK14 MAPK3 MAPK8
4 MAP kinase kinase activity GO:0004708 9.37 MAPK14 MAPK3
5 BH3 domain binding GO:0051434 8.96 BAX BCL2L1
6 MAP kinase activity GO:0004707 8.8 MAPK14 MAPK3 MAPK8

Sources for Carbuncle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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