Aliases & Classifications for Carbuncle

MalaCards integrated aliases for Carbuncle:

Name: Carbuncle 12 44 15 73
Carbuncle and Furuncle of Any Part of Face Except Eye 12
Carbuncle and Furuncle of Upper Arm and Forearm 12
Carbuncle and Furuncle of Leg Except Foot 12
Carbuncle and Furuncle of Gluteal Region 12
Carbuncle and Furuncle of Buttock 12
Carbuncle and Furuncle of Trunk 12
Carbuncle and Furuncle of Face 12
Carbuncle and Furuncle of Foot 12
Carbuncle and Furuncle of Hand 12
Carbuncle and Furuncle of Neck 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2176
ICD9CM 35 680.9
MeSH 44 D002270

Summaries for Carbuncle

MalaCards based summary : Carbuncle, also known as carbuncle and furuncle of any part of face except eye, is related to lung cancer and pyoderma. An important gene associated with Carbuncle is SPAG1 (Sperm Associated Antigen 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Povidone and Iodine have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and kidney, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 76 A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus... more...

Related Diseases for Carbuncle

Diseases related to Carbuncle via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 lung cancer 29.0 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
2 pyoderma 11.1
3 impetigo 10.1
4 cornea cancer 10.0 CDK4 FGF2
5 griscelli syndrome, type 1 10.0 CASP9 CDK4 CYCS
6 diffuse glomerulonephritis 10.0 FGF2 LYZ
7 aleukemic leukemia cutis 10.0 LYZ MPO SPN
8 nephrolithiasis 10.0
9 erysipelas 10.0
10 pyelonephritis 10.0
11 nephrotic syndrome 10.0
12 melanoma 10.0
13 folliculitis 10.0
14 acute pyelonephritis 10.0
15 peritonitis 10.0
16 intestinal obstruction 10.0
17 headache 10.0
18 adamantinoma of long bones 9.9 BAX CASP9 CDK4 FGF2
19 acute promyelocytic leukemia 9.9 BAX CASP9 CYCS MPO
20 breast adenocarcinoma 9.9 BAX BCL2L1 CASP9 CYCS
21 myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency 9.8 BCL2L1 CYCS
22 myeloma, multiple 9.8 BCL2L1 CASP9 CDK4 FGF2
23 squamous cell carcinoma, head and neck 9.8 BCL2L1 CASP9 CDK4 FGF2
24 cervical cancer 9.8 BAX CASP9 CDK2 CYCS MAPK3
25 lung cancer susceptibility 3 9.8 BCL2L1 CASP9 CDK4 CYCS
26 mantle cell lymphoma 9.7 BCL2L1 CDK4 SPN
27 nasopharyngeal carcinoma 9.7 BCL2L1 CASP9 CDK4 CYCS NFKBIA
28 ewing sarcoma 9.6 CASP9 CDK2 CDK4 CYCS FGF2 MAPK3
29 large intestine cancer 9.6 BCL2L1 CASP9 CDK2 CDK4 CYCS MAPK3
30 esophageal cancer 9.6 BAX BCL2L1 CASP9 CDK4 FGF2 MAPK3
31 prostate cancer 9.2 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
32 breast cancer 9.0 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS

Graphical network of the top 20 diseases related to Carbuncle:



Diseases related to Carbuncle

Symptoms & Phenotypes for Carbuncle

GenomeRNAi Phenotypes related to Carbuncle according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.9 CDK2 MAPK3
2 Decreased substrate adherent cell growth GR00193-A-2 9.9 CDK2 CDK4 MAPK14 MAPK3
3 Decreased substrate adherent cell growth GR00193-A-3 9.9 CDK2 CDK4 MAPK3
4 Decreased substrate adherent cell growth GR00193-A-4 9.9 CDK2 CDK4
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 BAX BCL2L1 CASP9 CDK2 MAPK3 MPO
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 BAX BCL2L1 CASP9 CDK2 MAPK3 MPO
7 Decreased viability with paclitaxel GR00179-A-1 9.35 BCL2L1 MAPK3
8 Decreased viability with paclitaxel GR00179-A-2 9.35 BCL2L1
9 Decreased viability with paclitaxel GR00179-A-3 9.35 BCL2L1 MAPK3

MGI Mouse Phenotypes related to Carbuncle:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.25 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
2 cellular MP:0005384 10.24 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3 endocrine/exocrine gland MP:0005379 10.22 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
4 homeostasis/metabolism MP:0005376 10.22 BAX BCL2L1 CDK2 CDK4 FGF2 LYZ
5 cardiovascular system MP:0005385 10.21 CASP9 CDK2 CDK4 CYCS FGF2 LYZ
6 growth/size/body region MP:0005378 10.2 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
7 immune system MP:0005387 10.15 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
8 mortality/aging MP:0010768 10.13 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
9 neoplasm MP:0002006 9.81 BAX BCL2L1 CDK2 CDK4 FGF2 LYZ
10 muscle MP:0005369 9.8 BAX CDK2 CDK4 FGF2 MAPK14 MAPK3
11 nervous system MP:0003631 9.65 BAX BCL2L1 CASP9 CDK4 CYCS FGF2
12 skeleton MP:0005390 9.23 BAX CYCS FGF2 LYZ MAPK14 MAPK3

Drugs & Therapeutics for Carbuncle

Drugs for Carbuncle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 4 9003-39-8
2
Iodine Approved, Investigational Phase 4 7553-56-2 807
3
Povidone-iodine Approved Phase 4 25655-41-8
4 Anti-Infective Agents Phase 4,Not Applicable
5 Blood Substitutes Phase 4
6 Plasma Substitutes Phase 4
7 cadexomer iodine Phase 4
8 Anti-Infective Agents, Local Phase 4
9
leucovorin Approved Not Applicable 58-05-9 6006 143
10
Cephalexin Approved, Investigational, Vet_approved Not Applicable 15686-71-2 27447
11
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
12
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
13
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
14
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
15 Anti-Bacterial Agents ,Not Applicable
16 methicillin ,Not Applicable
17 Vitamin B9 Not Applicable
18 Antiparasitic Agents Not Applicable
19 Antibiotics, Antitubercular Not Applicable
20 Anti-Infective Agents, Urinary Not Applicable
21 Clindamycin palmitate Not Applicable
22 Clindamycin phosphate Not Applicable
23 Vitamin B Complex Not Applicable
24 Cytochrome P-450 Enzyme Inhibitors Not Applicable
25 Folic Acid Antagonists Not Applicable
26 Renal Agents Not Applicable
27 Antimalarials Not Applicable
28 Antiprotozoal Agents Not Applicable
29 Folate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Skin and Soft Tissue Infection (SSTI) Study Completed NCT02600871 Phase 4 Provodine
2 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
3 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
4 Effective Antibiotic Treatment of MRSA Completed NCT00388310 Not Applicable

Search NIH Clinical Center for Carbuncle

Cochrane evidence based reviews: carbuncle

Genetic Tests for Carbuncle

Anatomical Context for Carbuncle

MalaCards organs/tissues related to Carbuncle:

41
Eye, Skin, Kidney, Lung, Bone, Breast, Prostate

Publications for Carbuncle

Articles related to Carbuncle:

(show top 50) (show all 95)
# Title Authors Year
1
Neck carbuncle associated with methicillin-susceptible Staphylococcus aureus bacteraemia. ( 30366898 )
2018
2
An Unusually Large Carbuncle of the Temporofacial Region Demonstrating Remarkable Post-debridement Wound Healing Process: A Case Report. ( 28448262 )
2017
3
Carbuncle due to Salmonella Enteritidis: a novel presentation. ( 28912837 )
2017
4
Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution. ( 28412984 )
2017
5
'Carbuncle in diabetes': a problem even today! ( 28630227 )
2017
6
Forehead carbuncle with intractable headache. ( 25848276 )
2015
7
Granulicatella adiacens--an unusual causative agent for carbuncle. ( 23455831 )
2012
8
Excision of carbuncle with primary split thickness skin grafting as a new treatment modality. ( 22883561 )
2012
9
Kidney metastasis of lung cancer presenting as renal carbuncle. ( 10368265 )
1999
10
The valgus and the carbuncle. ( 27517372 )
1999
11
A polypous carbuncle. ( 9585897 )
1998
12
A case of carbuncle caused by a catalase-negative strain of staphylococcus aureus. ( 8831037 )
1996
13
Case study: carbuncle of the neck with extensive tunnelling. ( 8489687 )
1993
14
Renal carbuncle presenting as acute peritonitis in pregnancy. ( 1884151 )
1991
15
Carbuncle--a conservative approach. ( 3681747 )
1987
16
Oral antibiotics and the renal carbuncle. ( 3775488 )
1986
17
Conservative approach in treating acute renal carbuncle. ( 3884550 )
1985
18
Renal carbuncle: comparison between surgical open drainage and closed percutaneous drainage. ( 3881871 )
1985
19
Management of "acute renal carbuncle". ( 7171951 )
1982
20
Renal carbuncle: diagnosis and management. ( 7222317 )
1981
21
A case of renal carbuncle-the role of radionuclides. ( 7388292 )
1980
22
Management of renal carbuncle. ( 671594 )
1978
23
Renal carbuncle in a neonate with congenital nephrotic syndrome. ( 349130 )
1978
24
A case of renal carbuncle. ( 388281 )
1978
25
Renal carbuncle: the use of ultrasound in its diagnosis and treatment. ( 916041 )
1977
26
Antibiotic treatment of renal carbuncle. ( 900675 )
1977
27
Acute renal carbuncle. ( 926263 )
1977
28
Renal carbuncle: simulation of tumor response to epinephrine. ( 601943 )
1977
29
Renal carbuncle: unusual cause of postpartum febrile morbidity. ( 943542 )
1976
30
Renal carbuncle: early diagnosis by retroperitoneal ultrasound. ( 1246759 )
1976
31
Diabetic carbuncle. ( 1075009 )
1975
32
Acute renal carbuncle: the importance of preoperative angiography. ( 4830871 )
1974
33
Carbuncle: discussion and a report of two cases. ( 4207521 )
1974
34
Renal carbuncle. ( 4723824 )
1973
35
Renal carbuncle. ( 4717842 )
1973
36
Renal carbuncle: antibiotic therapy governed by ultrasonically guided aspiration. ( 4699670 )
1973
37
Acute renal carbuncle. The roentgenographic clarification of a medical enigma. ( 4566089 )
1972
38
Segmental acute pyelonephritis. A precursor to renal carbuncle or abscess? ( 5070143 )
1972
39
Arteriography and antibiotic therapy of a renal carbuncle. ( 5014349 )
1972
40
The roentgen features of renal carbuncle. ( 5082732 )
1972
41
[Renal carbuncle with xanthogranulomatous change: report of a case]. ( 5465187 )
1970
42
Carbuncle of the kidney. ( 5943895 )
1966
43
MALIGNANT MELANOMA DEVELOPING IN A URETHRAL CARBUNCLE. ( 14204613 )
1964
44
Renal carbuncle with perforation into the peritoneal cavity. ( 13760235 )
1960
45
Renal carbuncle; report of a response to modern treatment. ( 13452010 )
1957
46
Carbuncle of the kidney. ( 13230543 )
1955
47
Chronic renal carbuncle with gross fibrous reaction. ( 13280695 )
1955
48
Renal carbuncle. ( 13125928 )
1953
49
Carbuncle caused by Gaffkya tetragena treated with oxytetracycline (terramycin). ( 13091374 )
1953
50
Renal carbuncle: a report of five cases, with some remarks on aetiology and treatment. ( 13070966 )
1953

Variations for Carbuncle

Expression for Carbuncle

Search GEO for disease gene expression data for Carbuncle.

Pathways for Carbuncle

Pathways related to Carbuncle according to GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 BAX BCL2L1 CASP9 CYCS FGF2 MAPK14
2
Show member pathways
13.88 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3
Show member pathways
13.31 BAX CASP9 FGF2 MAPK3 NFKBIA PTPN1
4
Show member pathways
13.05 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
5
Show member pathways
13.01 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
6
Show member pathways
12.87 BAX BCL2L1 CASP9 CYCS MAPK3 NFKBIA
7
Show member pathways
12.85 CASP9 CDK2 CDK4 CYCS MAPK14 MAPK3
8
Show member pathways
12.82 BAX BCL2L1 CDK2 CDK4 FGF2 MAPK3
9
Show member pathways
12.77 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
10
Show member pathways
12.76 BAX CASP9 CDK2 CDK4 CYCS MAPK14
11
Show member pathways
12.74 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
12
Show member pathways
12.73 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
13
Show member pathways
12.72 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
14
Show member pathways
12.71 CASP9 CYCS MAPK14 MAPK3 NFKBIA
15
Show member pathways
12.67 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
16
Show member pathways
12.66 CASP9 CYCS MAPK14 MAPK3 NFKBIA
17
Show member pathways
12.63 BCL2L1 CASP9 MAPK14 MAPK3 NFKBIA
18 12.63 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
19
Show member pathways
12.62 BAX BCL2L1 CASP9 CYCS MAPK3
20
Show member pathways
12.61 BCL2L1 MAPK14 MAPK3 NFKBIA
21
Show member pathways
12.56 BAX BCL2L1 MAPK14 MAPK3 NFKBIA PTPN1
22
Show member pathways
12.52 CASP9 CYCS MAPK14 MAPK3
23
Show member pathways
12.51 BAX BCL2L1 CASP9 MAPK14 NFKBIA
24
Show member pathways
12.5 BCL2L1 FGF2 MAPK14 MAPK3 NFKBIA
25
Show member pathways
12.46 CDK4 MAPK14 MAPK3 NFKBIA
26
Show member pathways
12.46 BAX BCL2L1 CASP9 FGF2 MAPK14 MAPK3
27
Show member pathways
12.45 BCL2L1 MAPK14 MAPK3 NFKBIA
28 12.45 BAX BCL2L1 CDK4 NFKBIA
29
Show member pathways
12.45 BAX BCL2L1 CASP9 MAPK14 MAPK3 NFKBIA
30
Show member pathways
12.43 CASP9 MAPK14 MAPK3 NFKBIA
31
Show member pathways
12.43 CASP9 MAPK14 MAPK3 NFKBIA
32
Show member pathways
12.43 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
33
Show member pathways
12.38 BCL2L1 MAPK14 MAPK3 NFKBIA
34
Show member pathways
12.37 BCL2L1 MAPK14 MAPK3 NFKBIA
35 12.37 BAX CDK2 CDK4 MAPK3 NFKBIA
36
Show member pathways
12.34 FGF2 MAPK14 MAPK3 NFKBIA
37 12.31 BAX CASP9 CYCS MAPK14 MAPK3
38
Show member pathways
12.3 CDK2 MAPK14 MAPK3 NFKBIA
39 12.29 BAX BCL2L1 CASP9 CYCS
40
Show member pathways
12.29 BCL2L1 CASP9 CYCS MAPK14 MAPK3 NFKBIA
41
Show member pathways
12.27 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK3
42
Show member pathways
12.25 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK14
43 12.25 BAX CASP9 CDK2 CDK4 CYCS MAPK14
44 12.24 BAX BCL2L1 CASP9 MAPK3
45 12.22 CDK2 CDK4 MAPK14 MAPK3
46 12.21 BAX BCL2L1 CASP9 CDK2 CDK4
47 12.2 BAX CASP9 CDK2 CDK4
48
Show member pathways
12.19 BAX CASP9 CYCS MAPK3
49
Show member pathways
12.17 CASP9 CYCS MAPK14 NFKBIA
50
Show member pathways
12.14 BCL2L1 CASP9 CYCS MAPK14 MAPK3

GO Terms for Carbuncle

Cellular components related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.97 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK14
2 cytosol GO:0005829 9.4 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3 Bcl-2 family protein complex GO:0097136 8.96 BAX BCL2L1

Biological processes related to Carbuncle according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 BAX CASP9 CDK2 MAPK14 MAPK3
2 regulation of gene expression GO:0010468 9.8 CDK4 MAPK14 MAPK3 NFKBIA
3 cellular response to tumor necrosis factor GO:0071356 9.78 MAPK14 MAPK3 NFKBIA
4 activation of MAPK activity GO:0000187 9.77 FGF2 MAPK14 MAPK3
5 response to toxic substance GO:0009636 9.74 BAX CDK4 MAPK3
6 apoptotic process GO:0006915 9.7 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 BAX BCL2L1 CASP9
8 response to muscle stretch GO:0035994 9.59 MAPK14 NFKBIA
9 positive regulation of macrophage chemotaxis GO:0010759 9.58 MAPK14 MAPK3
10 regulation of ossification GO:0030278 9.58 MAPK14 MAPK3
11 cellular response to organic substance GO:0071310 9.58 BAX MAPK14 MAPK3
12 response to muramyl dipeptide GO:0032495 9.56 MAPK14 NFKBIA
13 signal transduction in response to DNA damage GO:0042770 9.55 CASP9 MAPK14
14 regulation of insulin receptor signaling pathway GO:0046626 9.54 CDK4 PTPN1
15 positive regulation of cytokine secretion involved in immune response GO:0002741 9.52 MAPK14 MAPK3
16 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.51 BAX PTPN1
17 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 MAPK14 MAPK3 NFKBIA
18 positive regulation of metallopeptidase activity GO:1905050 9.43 MAPK14 MAPK3
19 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 BAX BCL2L1 CASP9
20 positive regulation of cyclase activity GO:0031281 9.37 MAPK14 MAPK3
21 response to lipopolysaccharide GO:0032496 9.35 CASP9 MAPK14 MAPK3 MPO NFKBIA
22 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 8.8 BAX CASP9 CYCS

Molecular functions related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.16 MAPK14 MAPK3
2 MAP kinase activity GO:0004707 8.96 MAPK14 MAPK3
3 BH3 domain binding GO:0051434 8.62 BAX BCL2L1

Sources for Carbuncle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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