Aliases & Classifications for Carbuncle

MalaCards integrated aliases for Carbuncle:

Name: Carbuncle 12 15 17 71
Carbuncle and Furuncle of Any Part of Face Except Eye 12
Carbuncle and Furuncle of Upper Arm and Forearm 12
Carbuncle and Furuncle of Leg Except Foot 12
Carbuncle and Furuncle of Gluteal Region 12
Carbuncle and Furuncle of Buttock 12
Carbuncle and Furuncle of Trunk 12
Carbuncle and Furuncle of Face 12
Carbuncle and Furuncle of Foot 12
Carbuncle and Furuncle of Hand 12
Carbuncle and Furuncle of Neck 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2176
ICD9CM 34 680.9
UMLS 71 C0007078 C0007079

Summaries for Carbuncle

MalaCards based summary : Carbuncle, also known as carbuncle and furuncle of any part of face except eye, is related to pyelonephritis and intestinal obstruction. An important gene associated with Carbuncle is XIRP1 (Xin Actin Binding Repeat Containing 1), and among its related pathways/superpathways are PAK Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The drugs leucovorin and Sulfamethoxazole have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and eye, and related phenotypes are Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) and cardiovascular system

Wikipedia : 74 A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus... more...

Related Diseases for Carbuncle

Diseases related to Carbuncle via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 pyelonephritis 30.1 TNF IL6 IL1B
2 intestinal obstruction 29.8 TNF IL6 ACHE
3 appendicitis 29.8 TNF IL6 IL1B
4 cellulitis 29.8 TNF IL6 IL1B
5 peritonitis 29.5 TNF IL6 IL1B
6 erysipelas 29.2 TNF IL6 IL1B CAT
7 physiological polycythemia 10.5 TNF IL1B
8 systemic onset juvenile idiopathic arthritis 10.4 TNF IL1B
9 staphylococcal toxic shock syndrome 10.4 TNF IL1B
10 anthrax disease 10.4
11 vulvar vestibulitis syndrome 10.4 TNF IL1B
12 palladium allergic contact dermatitis 10.4 TNF IL1B
13 kashin-beck disease 10.4 TNF IL1B
14 congenital cytomegalovirus 10.3 TNF IL1B
15 jejunoileitis 10.3 TNF IL1B
16 diabetes mellitus 10.3
17 metal allergy 10.3 TNF IL1B
18 actinic prurigo 10.3 TNF IL1B
19 discitis 10.3 TXNDC12 TST
20 pyomyositis 10.2 TST NR4A1
21 thrombosis 10.2
22 hidradenitis 10.2
23 impetigo 10.2
24 shigellosis 10.2 TNF NFKBIA IL1B
25 staphyloenterotoxemia 10.2 TST NR4A1
26 helicobacter pylori infection 10.2 NFKBIA IL1B CASP3
27 newcastle disease 10.1 TNF NFKBIA CASP3
28 external pathological resorption 10.1 TNF IL6
29 scorpion envenomation 10.1 TNF IL6
30 lung cancer 10.1
31 melanoma, cutaneous malignant 10 10.1
32 nephrotic syndrome 10.1
33 melanoma 10.1
34 agammaglobulinemia 10.1
35 familial nephrotic syndrome 10.1
36 kidney cancer 10.1
37 cavernous sinus thrombosis 10.1
38 folliculitis 10.1
39 acute pyelonephritis 10.1
40 nephrolithiasis 10.1
41 pemphigus 10.1
42 neurofibroma 10.1
43 exfoliative dermatitis 10.1
44 headache 10.1
45 lymphadenitis 10.0 TNF IL1B CASP3
46 transient cerebral ischemia 10.0 IL1B CASP3 ACHE
47 prosthetic joint infection 10.0 IL6 IL1B
48 periodontitis, chronic 10.0 IL6 IL1B
49 idiopathic anterior uveitis 10.0 TNF IL6
50 streptococcal toxic-shock syndrome 10.0 TNF IL6

Graphical network of the top 20 diseases related to Carbuncle:



Diseases related to Carbuncle

Symptoms & Phenotypes for Carbuncle

GenomeRNAi Phenotypes related to Carbuncle according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 8.92 CASP3 CAT MAPK8 TNF

MGI Mouse Phenotypes related to Carbuncle:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 CASP3 CYCS DDIAS IL1B IL6 MAPK8
2 endocrine/exocrine gland MP:0005379 9.76 CASP3 CYCS IL6 MAPK8 NFKBIA NR4A1
3 hematopoietic system MP:0005397 9.7 ACHE CASP3 CYCS DDIAS IL1B IL6
4 neoplasm MP:0002006 9.1 CAT IL1B IL6 MAPK8 NR4A1 TNF

Drugs & Therapeutics for Carbuncle

Drugs for Carbuncle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 4 58-05-9 6006 143
2
Sulfamethoxazole Approved Phase 4 723-46-6 5329
3
Simethicone Approved Phase 4 8050-81-5
4
Trimethoprim Approved, Vet_approved Phase 4 738-70-5 5578
5
Iodine Approved, Investigational Phase 4 7553-56-2 807
6
Povidone-iodine Approved Phase 4 25655-41-8
7
Povidone Approved Phase 4 9003-39-8
8
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Anti-Infective Agents Phase 4
11 Folic Acid Antagonists Phase 4
12 Aluminum hydroxide, magnesium hydroxide, drug combination Phase 4
13 Anti-Bacterial Agents Phase 4
14 Vitamin B Complex Phase 4
15 Emollients Phase 4
16 Antiparasitic Agents Phase 4
17 Folate Phase 4
18 Antiprotozoal Agents Phase 4
19 Trimethoprim, Sulfamethoxazole Drug Combination Phase 4
20 Dermatologic Agents Phase 4
21 Antibiotics, Antitubercular Phase 4
22 Vitamin B9 Phase 4
23 Antimalarials Phase 4
24 Anti-Infective Agents, Local Phase 4
25 Plasma Substitutes Phase 4
26 Blood Substitutes Phase 4
27 cadexomer iodine Phase 4
28
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
29
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
30 Trace Elements
31 Micronutrients
32 Vitamins
33 Hormones
34 Nutrients
35 Calcium, Dietary
36 Calciferol
37
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Double Blinded Randomized Controlled Trial for the Management of Pediatric Community Acquired Skin Abscesses - To Treat or Not to Treat With Antibiotics Completed NCT00679302 Phase 4 Trimethoprim-sulfamethoxazole;Placebo group
2 Randomized Clinical Trial of Wound Packing Following Incision and Drainage of Superficial Skin Abscesses in the Pediatric Emergency Department Completed NCT00746109 Phase 4
3 Skin and Soft Tissue Infection (SSTI) Study Completed NCT02600871 Phase 4 Provodine
4 Effectiveness of Vitamin D Supplementation to Reduce Injury and Illness in the UK Armed Forces With Specific Reference to Stress Fracture Risk Reduction Recruiting NCT03963128
5 Therapeutic Efficacy of Homoeopathic Mother Tincture of "Abroma Agusta" in Changing the Level of Glycated Hb (HbA1c %) in Diabetes Mellitus Type II (NIDDM Available NCT02065674 Abroma Augusta Q (mother tincture)

Search NIH Clinical Center for Carbuncle

Genetic Tests for Carbuncle

Anatomical Context for Carbuncle

MalaCards organs/tissues related to Carbuncle:

40
Skin, Kidney, Eye, Lung, Breast, Heart, Colon

Publications for Carbuncle

Articles related to Carbuncle:

(show top 50) (show all 282)
# Title Authors PMID Year
1
Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. 61
32446927 2020
2
Satisfactory response of a back carbuncle to 5-aminolevulinic acid (ALA) photodynamic therapy: A case report. 61
31841685 2020
3
Buttock carbuncle with severe hypothermia and disturbed consciousness: When os odontoideum is the answer. 61
32526484 2020
4
Severe bacterial skin infections. 61
32507327 2020
5
Ethanol extract of Elephantopus scaber Linn. Attenuates inflammatory response via the inhibition of NF-κB signaling by dampening p65-DNA binding activity in lipopolysaccharide-activated macrophages. 61
31877363 2020
6
Association of Atopic Dermatitis With Bacterial, Fungal, Viral, and Sexually Transmitted Skin Infections. 61
32049716 2020
7
[Study on literature of Echinacea purpurea and discussion on its herbalization]. 61
32237435 2020
8
Traditional uses, phytochemistry, and pharmacology of Persicaria orientalis (L.) Spach - A review. 61
31751652 2020
9
[Bilateral acute purulent destructive pyelonephritis after retrograde ureteroscopy and lithotripsy]. 61
31808644 2019
10
β-Caryophyllene in the Essential Oil from Chrysanthemum Boreale Induces G1 Phase Cell Cycle Arrest in Human Lung Cancer Cells. 61
31635244 2019
11
Development of multicomponent lattice Boltzmann flux solver for simulation of compressible viscous reacting flows. 61
31639947 2019
12
Pharmacognostical study of Desmodium caudatum. 61
31241702 2019
13
Silk fibroin peptide suppresses proliferation and induces apoptosis and cell cycle arrest in human lung cancer cells. 61
29921888 2019
14
A review of the ethnopharmacology, phytochemistry, and pharmacology of Changium smyrnioides Wolff. 61
30182179 2019
15
[Systematic review and comment on modern study of Xiaojin Pills]. 61
30717523 2018
16
[Application of delayed skin-stretching device in treatment of skin and soft tissue defects]. 61
30215495 2018
17
Neck carbuncle associated with methicillin-susceptible Staphylococcus aureus bacteraemia. 61
30366898 2018
18
[Anti-inflammatory mechanism of heat-clearing and detoxifying Chinese herbs]. 61
30384547 2018
19
The chemistry and pharmacology of Ligularia przewalskii: A review. 61
29526703 2018
20
Deep Neck Space Infections-A Study in Diabetic Population in a Tertiary Care Centre. 61
29456938 2018
21
Phytochemistry, pharmacology, quality control and future research of Forsythia suspensa (Thunb.) Vahl: A review. 61
28887216 2018
22
Ethnomedicine, Phytochemistry and Pharmacology of Smilax glabra: An Important Traditional Chinese Medicine. 61
29433390 2018
23
Pressure- and dose-controlled transcutaneous pneumatic injection of hypertonic glucose solution for the treatment of atrophic skin disorders. 61
28665146 2017
24
Influence of low-level laser on pain and inflammation in type 2 diabetes mellitus with diabetic dermopathy - A case report. 61
28494177 2017
25
Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution. 61
28412984 2017
26
'Carbuncle in diabetes': a problem even today! 61
28630227 2017
27
An Unusually Large Carbuncle of the Temporofacial Region Demonstrating Remarkable Post-debridement Wound Healing Process: A Case Report. 61
28448262 2017
28
Uncommon Odontogenic Orocutaneous Fistula of the Jaw Treated with Platelet-Rich Fibrin. 61
28458932 2017
29
Bioactive alkaloids from the aerial parts of Houttuynia cordata. 61
27840258 2017
30
Carbuncle due to Salmonella Enteritidis: a novel presentation. 61
28912837 2017
31
The Genus Patrinia: A Review of Traditional Uses, Phytochemical and Pharmacological Studies. 61
28595500 2017
32
Apoptotic effects of extract from Cnidium monnieri (L.) Cusson by adenosine monosphosphate-activated protein kinase-independent pathway in HCT116 colon cancer cells. 61
27082059 2016
33
Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice. 61
27023331 2016
34
Anti-inflammatory effects, nuclear magnetic resonance identification, and high-performance liquid chromatography isolation of the total flavonoids from Artemisia frigida. 61
28911593 2016
35
Genome Sequence of Bacillus pumilus Strain Bonn, Isolated from an Anthrax-Like Necrotic Skin Infection Site of a Child. 61
26868410 2016
36
Gleditsia species: An ethnomedical, phytochemical and pharmacological review. 61
26643065 2016
37
Investigation of the mechanisms of Angelica dahurica root extract-induced vasorelaxation in isolated rat aortic rings. 61
26520575 2015
38
Myeloid Sarcoma Masquerading as Granulation Tissue: A Diagnostic Pitfall. 61
26063639 2015
39
Who leaves the hospital against medical advice in the orthopaedic setting? 61
25187333 2015
40
Forehead carbuncle with intractable headache. 61
25848276 2015
41
[Renal carbuncle and perirenal abscess in children and adolescents]. 61
25190305 2014
42
Infection of the Beard area. Kerion: a review of 2 cases. 61
25226722 2014
43
Study on anti-osteosarcoma activity of ethanol extract of Venenum bufonis in vitro. 61
24653556 2014
44
Excision of carbuncle with primary split-thickness skin grafting as a new treatment modality. 61
22883561 2013
45
First imported case of skin infection caused by PVL-positive ST30 community-associated methicillin-resistant Staphylococcus aureus clone in a returning Korean traveler from the Philippines. 61
23853497 2013
46
Complete Genome Sequence of Propionibacterium avidum Strain 44067, Isolated from a Human Skin Abscess. 61
23792747 2013
47
Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells. 61
23381601 2013
48
Evaluation of anti-bacterial and wound healing activity of the fruits of Amorpha fruticosa L. 61
24146475 2013
49
Granulicatella adiacens--an unusual causative agent for carbuncle. 61
23455831 2012
50
Fournier's gangrene -- analysis of management and outcome in south-eastern Nigeria. 61
22353315 2012

Variations for Carbuncle

Expression for Carbuncle

Search GEO for disease gene expression data for Carbuncle.

Pathways for Carbuncle

Pathways related to Carbuncle according to GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.31 TNF NFKBIA MAPK8 IL6 IL1B CASP3
2
Show member pathways
13.3 TNF MAPK8 IL6 IL1B CYCS CASP3
3
Show member pathways
13.19 TNF MAPK8 IL6 IL1B CYCS CASP3
4
Show member pathways
13.1 TNF NFKBIA MAPK8 IL6 CYCS CASP3
5
Show member pathways
13.02 TNF NFKBIA MAPK8 IL6 IL1B CYCS
6
Show member pathways
12.89 TNF NFKBIA MAPK8 IL6 IL1B CYCS
7
Show member pathways
12.88 TNF IL6 IL1B CYCS CASP3
8 12.87 NFKBIA MAPK8 IL6 CYCS CASP3
9 12.79 TNF NR4A1 MAPK8 IL1B CASP3
10 12.79 TNF NFKBIA IL6 IL1B CYCS CASP3
11
Show member pathways
12.76 TNF NFKBIA MAPK8 IL6 IL1B
12
Show member pathways
12.76 TNF NFKBIA MAPK8 IL6 IL1B CYCS
13
Show member pathways
12.73 TNF NFKBIA MAPK8 CYCS CASP3
14
Show member pathways
12.69 TNF NFKBIA MAPK8 IL1B CASP3
15
Show member pathways
12.63 TNF NFKBIA MAPK8 IL6 IL1B
16
Show member pathways
12.62 TNF NFKBIA MAPK8 IL6 IL1B
17
Show member pathways
12.61 TNF NFKBIA MAPK8 IL6 IL1B
18 12.58 TNF NR4A1 NFKBIA IL1B
19
Show member pathways
12.54 TNF NFKBIA MAPK8 IL1B CYCS CASP3
20
Show member pathways
12.51 NFKBIA MAPK8 IL1B CASP3
21
Show member pathways
12.47 NFKBIA MAPK8 IL1B CASP3
22 12.39 TNF NFKBIA MAPK8 IL1B CYCS
23 12.38 TNF NFKBIA MAPK8 IL6
24
Show member pathways
12.36 TNF IL6 IL1B CAT
25
Show member pathways
12.33 TNF NFKBIA MAPK8 IL6 IL1B
26 12.29 TNF NR4A1 CYCS CASP3
27
Show member pathways
12.24 TNF MAPK8 CYCS CASP3
28
Show member pathways
12.24 TNF NFKBIA MAPK8 IL6 IL1B CASP3
29 12.23 TNF NFKBIA MAPK8 IL6 IL1B
30
Show member pathways
12.22 TNF NFKBIA IL6 IL1B
31 12.21 TNF IL6 IL1B CASP3
32
Show member pathways
12.19 TNF NFKBIA MAPK8 IL6 IL1B
33 12.16 TNF IL1B CYCS CASP3
34
Show member pathways
12.16 TNF NFKBIA MAPK8 IL1B CYCS CASP3
35 12.07 TNF NFKBIA MAPK8 IL1B
36
Show member pathways
12.05 TNF MAPK8 CYCS CASP3
37 12.05 TNF MAPK8 IL6 IL1B CYCS CASP3
38 12.01 TNF NFKBIA MAPK8 IL6 IL1B CYCS
39 12 TNF IL6 IL1B
40
Show member pathways
12 NFKBIA MAPK8 IL1B
41
Show member pathways
11.99 TNF NFKBIA MAPK8 IL6
42 11.97 TNF NFKBIA MAPK8 IL6 IL1B
43
Show member pathways
11.96 TNF IL6 IL1B
44 11.95 TNF NFKBIA IL1B
45 11.95 TNF IL6 IL1B CASP3
46 11.95 TNF NR4A1 IL6 IL1B CASP3
47 11.93 TNF IL6 IL1B
48 11.9 TNF IL6 IL1B
49 11.9 TNF CYCS CAT CASP3
50 11.89 NFKBIA CYCS CASP3

GO Terms for Carbuncle

Biological processes related to Carbuncle according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.02 TNF NR4A1 NFKBIA IL6 IL1B
2 negative regulation of apoptotic process GO:0043066 9.99 NFKBIA MAPK8 IL6 CAT CASP3
3 apoptotic process GO:0006915 9.93 NR4A1 NFKBIA IL1B DDIAS CYCS CASP3
4 cytokine-mediated signaling pathway GO:0019221 9.91 TNF IL6 IL1B CASP3
5 cellular response to lipopolysaccharide GO:0071222 9.84 TNF MAPK8 IL6 IL1B
6 response to lipopolysaccharide GO:0032496 9.81 NR4A1 NFKBIA IL1B CASP3
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 TNF IL6 IL1B CAT
8 positive regulation of inflammatory response GO:0050729 9.77 TNF NFKBIA IL1B
9 cellular response to organic cyclic compound GO:0071407 9.75 TNF IL1B CASP3
10 response to glucocorticoid GO:0051384 9.74 TNF IL6 CASP3
11 positive regulation of interleukin-6 production GO:0032755 9.73 TNF IL6 IL1B
12 response to UV GO:0009411 9.7 MAPK8 CAT CASP3
13 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.64 TNF IL1B
14 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.63 TNF IL1B
15 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.63 TNF IL1B
16 positive regulation of apoptotic process GO:0043065 9.63 TNF SCIN NR4A1 MAPK8 IL6 CASP3
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.62 TNF IL6
18 positive regulation of chemokine biosynthetic process GO:0045080 9.61 TNF IL1B
19 regulation of establishment of endothelial barrier GO:1903140 9.58 TNF IL1B
20 cellular response to organic substance GO:0071310 9.58 NR4A1 IL1B CASP3
21 positive regulation of fever generation GO:0031622 9.55 TNF IL1B
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.54 TNF NFKBIA IL1B
23 negative regulation of neurogenesis GO:0050768 9.5 TNF IL6 IL1B
24 sequestering of triglyceride GO:0030730 9.49 TNF IL1B
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.43 TNF IL1B
26 positive regulation of glial cell proliferation GO:0060252 9.43 TNF IL6 IL1B
27 positive regulation of neuroinflammatory response GO:0150078 9.13 TNF IL6 IL1B
28 negative regulation of lipid storage GO:0010888 8.8 TNF NFKBIA IL6

Sources for Carbuncle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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