Aliases & Classifications for Carbuncle

MalaCards integrated aliases for Carbuncle:

Name: Carbuncle 12 45 15 17 74
Carbuncle and Furuncle of Any Part of Face Except Eye 12
Carbuncle and Furuncle of Upper Arm and Forearm 12
Carbuncle and Furuncle of Leg Except Foot 12
Carbuncle and Furuncle of Gluteal Region 12
Carbuncle and Furuncle of Buttock 12
Carbuncle and Furuncle of Trunk 12
Carbuncle and Furuncle of Face 12
Carbuncle and Furuncle of Foot 12
Carbuncle and Furuncle of Hand 12
Carbuncle and Furuncle of Neck 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2176
ICD9CM 36 680.9
MeSH 45 D002270

Summaries for Carbuncle

MalaCards based summary : Carbuncle, also known as carbuncle and furuncle of any part of face except eye, is related to lung cancer and pyoderma. An important gene associated with Carbuncle is SPAG1 (Sperm Associated Antigen 1), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Iodine and Povidone have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and kidney, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Wikipedia : 77 A carbuncle is a cluster of boils caused by bacterial infection, most commonly with Staphylococcus... more...

Related Diseases for Carbuncle

Diseases related to Carbuncle via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 lung cancer 28.6 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
2 pyoderma 11.1
3 cornea cancer 10.2 CDK4 FGF2
4 impetigo 10.1
5 pasteurellosis 10.1 ALB MPO
6 griscelli syndrome, type 1 10.1 CASP9 CDK4 CYCS
7 diffuse glomerulonephritis 10.0 ALB FGF2
8 nephrolithiasis 10.0
9 erysipelas 10.0
10 pyelonephritis 10.0
11 nephrotic syndrome 10.0
12 melanoma 10.0
13 cellulitis 10.0
14 folliculitis 10.0
15 acute pyelonephritis 10.0
16 peritonitis 10.0
17 intestinal obstruction 10.0
18 headache 10.0
19 adamantinoma of long bones 9.9 BAX CASP9 CDK4 FGF2
20 myasthenic syndrome, congenital, 9, associated with acetylcholine receptor deficiency 9.9 BCL2L1 CYCS
21 acute promyelocytic leukemia 9.9 BAX CASP9 CYCS MPO
22 breast adenocarcinoma 9.8 BAX BCL2L1 CASP9 CYCS
23 decubitus ulcer 9.8 ALB FGF2
24 nasopharyngeal carcinoma 9.8 BCL2L1 CASP9 CDK4 NFKBIA
25 squamous cell carcinoma, head and neck 9.7 BCL2L1 CASP9 CDK4 FGF2
26 cervical cancer 9.7 BAX CASP9 CDK2 CYCS MAPK3
27 proteasome-associated autoinflammatory syndrome 1 9.7 ALB MAPK14 MPO
28 lung cancer susceptibility 3 9.7 BCL2L1 CASP9 CDK4 CYCS
29 mantle cell lymphoma 9.6 BCL2L1 CDK4 SPN
30 myeloma, multiple 9.5 ALB BCL2L1 CASP9 CDK4 FGF2
31 ewing sarcoma 9.2 ALB CASP9 CDK2 CDK4 CYCS FGF2
32 large intestine cancer 9.1 ALB BCL2L1 CASP9 CDK2 CDK4 CYCS
33 esophageal cancer 9.1 ALB BAX BCL2L1 CASP9 CDK4 FGF2
34 hepatocellular carcinoma 9.1 ALB BAX BCL2L1 CASP9 CDK4 FGF2
35 prostate cancer 8.9 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
36 breast cancer 8.5 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS

Graphical network of the top 20 diseases related to Carbuncle:



Diseases related to Carbuncle

Symptoms & Phenotypes for Carbuncle

GenomeRNAi Phenotypes related to Carbuncle according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.9 CDK2 MAPK3
2 Decreased substrate adherent cell growth GR00193-A-2 9.9 CDK2 CDK4 MAPK14 MAPK3
3 Decreased substrate adherent cell growth GR00193-A-3 9.9 CDK2 CDK4 MAPK3
4 Decreased substrate adherent cell growth GR00193-A-4 9.9 CDK2 CDK4
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 BAX BCL2L1 CASP9 CDK2 MAPK3 MPO
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 BAX BCL2L1 CASP9 CDK2 MAPK3 MPO
7 Decreased viability with paclitaxel GR00179-A-1 9.35 BCL2L1 MAPK3
8 Decreased viability with paclitaxel GR00179-A-2 9.35 BCL2L1
9 Decreased viability with paclitaxel GR00179-A-3 9.35 BCL2L1 MAPK3

MGI Mouse Phenotypes related to Carbuncle:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 ALB BAX BCL2L1 CASP9 CDK2 CDK4
2 endocrine/exocrine gland MP:0005379 10.17 ALB BAX BCL2L1 CASP9 CDK2 CDK4
3 hematopoietic system MP:0005397 10.15 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
4 cardiovascular system MP:0005385 10.13 CASP9 CDK2 CDK4 CYCS FGF2 MAPK14
5 homeostasis/metabolism MP:0005376 10.13 ALB BAX BCL2L1 CDK2 CDK4 FGF2
6 growth/size/body region MP:0005378 10.1 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
7 immune system MP:0005387 10 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
8 mortality/aging MP:0010768 9.97 ALB BAX BCL2L1 CASP9 CDK2 CDK4
9 muscle MP:0005369 9.56 ALB BAX CDK2 CDK4 FGF2 MAPK14
10 neoplasm MP:0002006 9.28 ALB BAX BCL2L1 CDK2 CDK4 FGF2

Drugs & Therapeutics for Carbuncle

Drugs for Carbuncle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4 7553-56-2 807
2
Povidone Approved Phase 4 9003-39-8
3
Povidone-iodine Approved Phase 4 25655-41-8
4 Anti-Infective Agents, Local Phase 4
5 cadexomer iodine Phase 4
6 Anti-Infective Agents Phase 4,Not Applicable
7 Plasma Substitutes Phase 4
8 Blood Substitutes Phase 4
9
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
10
Sulfamethoxazole Approved Not Applicable 723-46-6 5329
11
Cephalexin Approved, Investigational, Vet_approved Not Applicable 15686-71-2 27447
12
leucovorin Approved Not Applicable 58-05-9 6006 143
13
Trimethoprim Approved, Vet_approved Not Applicable 738-70-5 5578
14
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
15 methicillin ,Not Applicable
16 Anti-Bacterial Agents ,Not Applicable
17 Cytochrome P-450 Enzyme Inhibitors Not Applicable
18 Vitamin B Complex Not Applicable
19 Antimalarials Not Applicable
20 Antiprotozoal Agents Not Applicable
21 Folic Acid Antagonists Not Applicable
22 Renal Agents Not Applicable
23 Clindamycin phosphate Not Applicable
24 Clindamycin palmitate Not Applicable
25 Antiparasitic Agents Not Applicable
26 Antibiotics, Antitubercular Not Applicable
27 Anti-Infective Agents, Urinary Not Applicable
28 Vitamin B9 Not Applicable
29 Folate Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Skin and Soft Tissue Infection (SSTI) Study Completed NCT02600871 Phase 4 Provodine
2 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
3 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
4 Effective Antibiotic Treatment of MRSA Completed NCT00388310 Not Applicable

Search NIH Clinical Center for Carbuncle

Cochrane evidence based reviews: carbuncle

Genetic Tests for Carbuncle

Anatomical Context for Carbuncle

MalaCards organs/tissues related to Carbuncle:

42
Eye, Skin, Kidney, Colon, Lung, Liver

Publications for Carbuncle

Articles related to Carbuncle:

(show top 50) (show all 95)
# Title Authors Year
1
Neck carbuncle associated with methicillin-susceptible Staphylococcus aureus bacteraemia. ( 30366898 )
2018
2
An Unusually Large Carbuncle of the Temporofacial Region Demonstrating Remarkable Post-debridement Wound Healing Process: A Case Report. ( 28448262 )
2017
3
Carbuncle due to Salmonella Enteritidis: a novel presentation. ( 28912837 )
2017
4
Facial carbuncle - a new method of conservative surgical management plus irrigation with antibiotic-containing solution. ( 28412984 )
2017
5
'Carbuncle in diabetes': a problem even today! ( 28630227 )
2017
6
Forehead carbuncle with intractable headache. ( 25848276 )
2015
7
Granulicatella adiacens--an unusual causative agent for carbuncle. ( 23455831 )
2012
8
Excision of carbuncle with primary split thickness skin grafting as a new treatment modality. ( 22883561 )
2012
9
Kidney metastasis of lung cancer presenting as renal carbuncle. ( 10368265 )
1999
10
The valgus and the carbuncle. ( 27517372 )
1999
11
A polypous carbuncle. ( 9585897 )
1998
12
A case of carbuncle caused by a catalase-negative strain of staphylococcus aureus. ( 8831037 )
1996
13
Case study: carbuncle of the neck with extensive tunnelling. ( 8489687 )
1993
14
Renal carbuncle presenting as acute peritonitis in pregnancy. ( 1884151 )
1991
15
Carbuncle--a conservative approach. ( 3681747 )
1987
16
Oral antibiotics and the renal carbuncle. ( 3775488 )
1986
17
Conservative approach in treating acute renal carbuncle. ( 3884550 )
1985
18
Renal carbuncle: comparison between surgical open drainage and closed percutaneous drainage. ( 3881871 )
1985
19
Management of "acute renal carbuncle". ( 7171951 )
1982
20
Renal carbuncle: diagnosis and management. ( 7222317 )
1981
21
A case of renal carbuncle-the role of radionuclides. ( 7388292 )
1980
22
Management of renal carbuncle. ( 671594 )
1978
23
Renal carbuncle in a neonate with congenital nephrotic syndrome. ( 349130 )
1978
24
A case of renal carbuncle. ( 388281 )
1978
25
Renal carbuncle: the use of ultrasound in its diagnosis and treatment. ( 916041 )
1977
26
Antibiotic treatment of renal carbuncle. ( 900675 )
1977
27
Acute renal carbuncle. ( 926263 )
1977
28
Renal carbuncle: simulation of tumor response to epinephrine. ( 601943 )
1977
29
Renal carbuncle: unusual cause of postpartum febrile morbidity. ( 943542 )
1976
30
Renal carbuncle: early diagnosis by retroperitoneal ultrasound. ( 1246759 )
1976
31
Diabetic carbuncle. ( 1075009 )
1975
32
Acute renal carbuncle: the importance of preoperative angiography. ( 4830871 )
1974
33
Carbuncle: discussion and a report of two cases. ( 4207521 )
1974
34
Renal carbuncle. ( 4723824 )
1973
35
Renal carbuncle. ( 4717842 )
1973
36
Renal carbuncle: antibiotic therapy governed by ultrasonically guided aspiration. ( 4699670 )
1973
37
Acute renal carbuncle. The roentgenographic clarification of a medical enigma. ( 4566089 )
1972
38
Segmental acute pyelonephritis. A precursor to renal carbuncle or abscess? ( 5070143 )
1972
39
Arteriography and antibiotic therapy of a renal carbuncle. ( 5014349 )
1972
40
The roentgen features of renal carbuncle. ( 5082732 )
1972
41
[Renal carbuncle with xanthogranulomatous change: report of a case]. ( 5465187 )
1970
42
Carbuncle of the kidney. ( 5943895 )
1966
43
MALIGNANT MELANOMA DEVELOPING IN A URETHRAL CARBUNCLE. ( 14204613 )
1964
44
Renal carbuncle with perforation into the peritoneal cavity. ( 13760235 )
1960
45
Renal carbuncle; report of a response to modern treatment. ( 13452010 )
1957
46
Carbuncle of the kidney. ( 13230543 )
1955
47
Chronic renal carbuncle with gross fibrous reaction. ( 13280695 )
1955
48
Renal carbuncle. ( 13125928 )
1953
49
Carbuncle caused by Gaffkya tetragena treated with oxytetracycline (terramycin). ( 13091374 )
1953
50
Renal carbuncle: a report of five cases, with some remarks on aetiology and treatment. ( 13070966 )
1953

Variations for Carbuncle

Expression for Carbuncle

Search GEO for disease gene expression data for Carbuncle.

Pathways for Carbuncle

Pathways related to Carbuncle according to GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 BAX BCL2L1 CASP9 CYCS FGF2 MAPK14
2
Show member pathways
13.88 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
3
Show member pathways
13.32 ALB CDK2 MAPK14 MAPK3 PTPN1 SPN
4
Show member pathways
13.31 BAX CASP9 FGF2 MAPK3 NFKBIA PTPN1
5
Show member pathways
13.04 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
6
Show member pathways
13.01 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
7
Show member pathways
12.86 BAX BCL2L1 CASP9 CYCS MAPK3 NFKBIA
8
Show member pathways
12.82 BAX BCL2L1 CDK2 CDK4 FGF2 MAPK3
9
Show member pathways
12.77 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
10
Show member pathways
12.76 BAX CASP9 CDK2 CDK4 CYCS MAPK14
11
Show member pathways
12.71 CASP9 CYCS MAPK14 MAPK3 NFKBIA
12
Show member pathways
12.71 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
13
Show member pathways
12.66 CASP9 CYCS MAPK14 MAPK3 NFKBIA
14
Show member pathways
12.65 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
15
Show member pathways
12.64 CASP9 CDK2 CDK4 CYCS MAPK14 MAPK3
16
Show member pathways
12.64 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
17
Show member pathways
12.63 BCL2L1 CASP9 MAPK14 MAPK3 NFKBIA
18
Show member pathways
12.63 BAX BCL2L1 CASP9 CDK2 CDK4 FGF2
19 12.63 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
20
Show member pathways
12.61 BAX BCL2L1 CASP9 CYCS MAPK3
21
Show member pathways
12.6 BCL2L1 MAPK14 MAPK3 NFKBIA
22
Show member pathways
12.56 BAX BCL2L1 MAPK14 MAPK3 NFKBIA PTPN1
23
Show member pathways
12.52 CASP9 CYCS MAPK14 MAPK3
24
Show member pathways
12.51 BAX BCL2L1 CASP9 MAPK14 NFKBIA
25
Show member pathways
12.5 BCL2L1 FGF2 MAPK14 MAPK3 NFKBIA
26
Show member pathways
12.46 CDK4 MAPK14 MAPK3 NFKBIA
27
Show member pathways
12.46 BAX BCL2L1 CASP9 FGF2 MAPK14 MAPK3
28
Show member pathways
12.45 BCL2L1 MAPK14 MAPK3 NFKBIA
29
Show member pathways
12.44 BAX BCL2L1 CASP9 MAPK14 MAPK3 NFKBIA
30
Show member pathways
12.43 CASP9 MAPK14 MAPK3 NFKBIA
31
Show member pathways
12.43 CASP9 MAPK14 MAPK3 NFKBIA
32
Show member pathways
12.42 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
33 12.39 BAX BCL2L1 CDK4 NFKBIA
34
Show member pathways
12.37 BCL2L1 MAPK14 MAPK3 NFKBIA
35
Show member pathways
12.37 BCL2L1 MAPK14 MAPK3 NFKBIA
36 12.37 BAX CDK2 CDK4 MAPK3 NFKBIA
37
Show member pathways
12.34 FGF2 MAPK14 MAPK3 NFKBIA
38 12.3 BAX CASP9 CYCS MAPK14 MAPK3
39
Show member pathways
12.29 CDK2 MAPK14 MAPK3 NFKBIA
40 12.29 BAX BCL2L1 CASP9 CYCS
41
Show member pathways
12.27 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK3
42
Show member pathways
12.27 BCL2L1 CASP9 CYCS MAPK14 MAPK3 NFKBIA
43 12.23 BAX BCL2L1 CASP9 MAPK3
44
Show member pathways
12.23 BAX BCL2L1 CASP9 CDK2 CDK4 MAPK14
45 12.21 CDK2 CDK4 MAPK14 MAPK3
46 12.21 BAX BCL2L1 CASP9 CDK2 CDK4
47 12.19 BAX CASP9 CDK2 CDK4
48
Show member pathways
12.19 BAX CASP9 CYCS MAPK3
49
Show member pathways
12.17 CASP9 CYCS MAPK14 NFKBIA
50
Show member pathways
12.14 BCL2L1 CASP9 CYCS MAPK14 MAPK3

GO Terms for Carbuncle

Cellular components related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.73 BAX BCL2L1 CASP9 CDK2 CDK4 CYCS
2 protein-containing complex GO:0032991 9.72 ALB CASP9 CDK4 MAPK3 PTPN1
3 cytoplasm GO:0005737 9.47 ALB BAX BCL2L1 CASP9 CDK2 CDK4
4 Bcl-2 family protein complex GO:0097136 9.16 BAX BCL2L1
5 nucleus GO:0005634 10.07 ALB BAX BCL2L1 CASP9 CDK2 CDK4

Biological processes related to Carbuncle according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.88 BAX CASP9 CDK2 MAPK14 MAPK3
2 regulation of gene expression GO:0010468 9.8 CDK4 MAPK14 MAPK3 NFKBIA
3 activation of MAPK activity GO:0000187 9.77 FGF2 MAPK14 MAPK3
4 response to toxic substance GO:0009636 9.74 BAX CDK4 MAPK3
5 apoptotic process GO:0006915 9.7 BAX BCL2L1 CASP9 CYCS MAPK14 MAPK3
6 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.63 BAX BCL2L1 CASP9
7 response to muscle stretch GO:0035994 9.59 MAPK14 NFKBIA
8 positive regulation of macrophage chemotaxis GO:0010759 9.58 MAPK14 MAPK3
9 regulation of ossification GO:0030278 9.58 MAPK14 MAPK3
10 cellular response to organic substance GO:0071310 9.58 BAX MAPK14 MAPK3
11 response to muramyl dipeptide GO:0032495 9.56 MAPK14 NFKBIA
12 signal transduction in response to DNA damage GO:0042770 9.55 CASP9 MAPK14
13 regulation of insulin receptor signaling pathway GO:0046626 9.54 CDK4 PTPN1
14 positive regulation of cytokine secretion involved in immune response GO:0002741 9.52 MAPK14 MAPK3
15 positive regulation of IRE1-mediated unfolded protein response GO:1903896 9.51 BAX PTPN1
16 lipopolysaccharide-mediated signaling pathway GO:0031663 9.5 MAPK14 MAPK3 NFKBIA
17 positive regulation of metallopeptidase activity GO:1905050 9.43 MAPK14 MAPK3
18 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 BAX BCL2L1 CASP9
19 positive regulation of cyclase activity GO:0031281 9.37 MAPK14 MAPK3
20 response to lipopolysaccharide GO:0032496 9.35 CASP9 MAPK14 MAPK3 MPO NFKBIA
21 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 8.8 BAX CASP9 CYCS

Molecular functions related to Carbuncle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAP kinase kinase activity GO:0004708 9.16 MAPK14 MAPK3
2 MAP kinase activity GO:0004707 8.96 MAPK14 MAPK3
3 BH3 domain binding GO:0051434 8.62 BAX BCL2L1

Sources for Carbuncle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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