MCID: CRD005
MIFTS: 43

Cardia Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cardia Cancer

MalaCards integrated aliases for Cardia Cancer:

Name: Cardia Cancer 12 15
Malignant Neoplasm of Cardia of Stomach 12
Ca Cardia - Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10548
ICD9CM 36 151.0
SNOMED-CT 69 93738008
ICD10 34 C16.0
UMLS 74 C0153417

Summaries for Cardia Cancer

MalaCards based summary : Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to gastric cancer and esophageal cancer. An important gene associated with Cardia Cancer is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Cytochrome P450 - arranged by substrate type and Drug metabolism - cytochrome P450. The drugs Capecitabine and Oxaliplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and breast, and related phenotype is Increased viability with MLN4924 (a NAE inhibitor).

Related Diseases for Cardia Cancer

Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 gastric cancer 29.6 GSTM1 GSTP1 GSTT1 MTHFR TP53 TYMS
2 esophageal cancer 27.8 CYP1A1 GSTM1 GSTP1 GSTT1 MDM2 PLCE1
3 hearing loss, noise-induced 10.3 GSTM1 GSTT1
4 hemifacial spasm 10.3 MTHFR TYMS
5 non-proliferative fibrocystic change of the breast 10.3 TP53 XRCC1
6 oligoasthenoteratozoospermia 10.3 GSTM1 GSTP1
7 isolated cleft lip 10.3 GSTM1 GSTT1
8 drug-induced hepatitis 10.2 GSTM1 GSTT1
9 ring chromosome 7 10.2 MDM2 TP53
10 zika virus infection 10.2 MDM2 TP53
11 nondisjunction 10.2 MTHFR MTRR
12 actinic cheilitis 10.2 MDM2 TP53
13 cheilitis 10.2 MDM2 TP53
14 sclerosing liposarcoma 10.2 MDM2 TP53
15 sister chromatid exchange, frequency of 10.2 GSTM1 GSTT1 XRCC1
16 lip cancer 10.2 MDM2 TP53
17 arteritic anterior ischemic optic neuropathy 10.2 GSTM1 GSTT1 MTHFR
18 ischemic optic neuropathy 10.2 GSTM1 GSTT1 MTHFR
19 senile cataract 10.2 GSTM1 GSTT1 XRCC1
20 gastric cardia carcinoma 10.2 MTHFR TYMS XRCC1
21 sapho syndrome 10.2 MDM2 TP53
22 differentiated thyroid carcinoma 10.2 MTHFR TP53 XRCC1
23 periosteal osteogenic sarcoma 10.2 MDM2 TP53
24 oral leukoplakia 10.2 GSTM1 TP53 XRCC1
25 diffuse gastric cancer 10.2 GSTM1 GSTP1 GSTT1
26 asbestosis 10.1 GSTM1 GSTP1 GSTT1
27 mucositis 10.1 MTHFR TYMS XRCC1
28 gliomatosis cerebri 10.1 MDM2 TP53
29 soft tissue sarcoma 10.1 MDM2 TP53
30 dedifferentiated liposarcoma 10.1 MDM2 TP53
31 small cell sarcoma 10.1 MDM2 TP53
32 laryngeal disease 10.1 GSTM1 GSTT1 TP53
33 helicobacter pylori infection 10.1
34 bladder disease 10.1 GSTM1 GSTT1 TP53
35 myxosarcoma 10.1 MDM2 TP53
36 bladder transitional cell papilloma 10.1 PARP1 TP53
37 maxillary cancer 10.1 TP53 TYMS
38 basal cell carcinoma 10.0 GSTM1 GSTT1 TP53
39 verrucous carcinoma 10.0 MDM2 TP53
40 adenocarcinoma 10.0
41 gastric cardia adenocarcinoma 10.0
42 dysphagia 10.0
43 embryonal sarcoma 10.0 MDM2 TP53
44 xeroderma pigmentosum, complementation group d 10.0 GSTM1 GSTP1 GSTT1 XRCC1
45 neural tube defects, folate-sensitive 10.0 MTHFR MTRR
46 gastrointestinal stromal tumor 10.0 MTHFR MTRR TP53
47 mutagen sensitivity 10.0 GSTM1 GSTT1 TP53 XRCC1
48 toxic oil syndrome 9.9 CYP1A1 GSTM1
49 gastroschisis 9.9 CYP1A1 MTHFR
50 squamous cell carcinoma, head and neck 9.9 GSTM1 GSTP1 GSTT1 TP53

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to Cardia Cancer

Symptoms & Phenotypes for Cardia Cancer

GenomeRNAi Phenotypes related to Cardia Cancer according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 MDM2 PARP1 TP53 TYMS XRCC1

Drugs & Therapeutics for Cardia Cancer

Drugs for Cardia Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Capecitabine Approved, Investigational Phase 2,Phase 1 154361-50-9 60953
2
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 43805 6857599 5310940 9887054
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Pertuzumab Approved Phase 2 380610-27-5, 145040-37-5 2540
5
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
6
Fluorouracil Approved Phase 2,Phase 1 51-21-8 3385
7
leucovorin Approved Phase 1, Phase 2,Phase 2 58-05-9 143 6006
8
Carboplatin Approved Phase 1, Phase 2 41575-94-4 10339178 38904 498142
9
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
10
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2
11
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
12
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
13
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
14 Antimetabolites Phase 2,Phase 1
15 Antimetabolites, Antineoplastic Phase 2,Phase 1
16 Nutrients Phase 1, Phase 2,Not Applicable
17 Trace Elements Phase 1, Phase 2,Not Applicable
18 Micronutrients Phase 1, Phase 2,Not Applicable
19 Antineoplastic Agents, Immunological Phase 2,Phase 1
20 Immunologic Factors Phase 2,Phase 1
21 Immunosuppressive Agents Phase 2,Phase 1
22 Hormones Phase 1, Phase 2
23 Bone Density Conservation Agents Phase 1, Phase 2
24 Antidotes Phase 1, Phase 2
25 Albumin-Bound Paclitaxel Phase 1, Phase 2
26 Vitamin B Complex Phase 1, Phase 2
27 Antimitotic Agents Phase 1, Phase 2
28 Vitamins Phase 1, Phase 2
29 Hematinics Phase 1, Phase 2
30 Folate Phase 1, Phase 2
31 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
32 Vitamin B9 Phase 1, Phase 2
33 Protective Agents Phase 1, Phase 2
34 Calcium, Dietary Phase 1, Phase 2
35
Epirubicin Approved Phase 1 56420-45-2 41867
36
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
37 Anti-Bacterial Agents Phase 1
38 Topoisomerase Inhibitors Phase 1
39 Antibiotics, Antitubercular Phase 1
40
Acetaminophen Approved 103-90-2 1983
41
Iodine Approved, Investigational Not Applicable 7553-56-2 807
42
Sulfasalazine Approved 599-79-1 5359476 5353980
43
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
44
Octreotide Approved, Investigational 83150-76-9 6400441 383414
45 Analgesics, Non-Narcotic
46 Analgesics
47 Peripheral Nervous System Agents
48 Antipyretics
49 Anti-Infective Agents, Local Not Applicable
50 Anti-Infective Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Neoadjuvant Study Using Trastuzumab or Trastuzumab With Pertuzumab in Gastric or Gastroesophageal Junction Adenocarcinoma Recruiting NCT02205047 Phase 2 Cisplatin;5-fluorouracil or Capecitabine;Trastuzumab;Pertuzumab
2 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Suspended NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
3 Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy for Resectable Esophageal Cancer Completed NCT01386346 Phase 1 Azacitidine;Oxaliplatin;Epirubicin;Capecitabine
4 Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer Unknown status NCT03032224
5 Quality of Life With Esophageal Stent Trial Unknown status NCT01044511 Not Applicable
6 Mediastinal Microdialysis in Patients With Oesophageal or Cardia Cancer Treated by Resection Completed NCT00686569
7 Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet Completed NCT02158286
8 Endoscopic Screening on Esophageal Cancer Completed NCT02094105 Not Applicable
9 Institut Paoli Calmettes Cardia Cancer Database Recruiting NCT02869477
10 Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study Recruiting NCT02491840 Not Applicable
11 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine

Search NIH Clinical Center for Cardia Cancer

Genetic Tests for Cardia Cancer

Anatomical Context for Cardia Cancer

MalaCards organs/tissues related to Cardia Cancer:

42
Lung, Bone, Breast, Heart, T Cells, Lymph Node, Spleen

Publications for Cardia Cancer

Articles related to Cardia Cancer:

(show top 50) (show all 86)
# Title Authors Year
1
Transhiatal distal esophagectomy for Siewert type II cardia cancer can be a treatment option in selected patients. ( 31005469 )
2019
2
Analyses on K-ras mutations and fascin expression in patients with cardia cancer. ( 30675241 )
2019
3
Comparisons between 2 surgeries for cardia cancer: total gastrectomy vs. proximal gastrectomy. ( 30657285 )
2019
4
Gastric Cardia Cancer Masquerading as a Fundic Subepithelial Tumor. ( 29899434 )
2018
5
18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study. ( 29743108 )
2018
6
Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. ( 29670922 )
2018
7
A case report of cardia cancer complicated with idiopathic muscular hypertrophy of the oesophagus treated with thoracoscopic surgery. ( 29067940 )
2018
8
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report. ( 29166433 )
2017
9
Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China. ( 28319273 )
2017
10
Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer. ( 28293089 )
2017
11
Three United Laparoscopic Surgery for the Treatment of Gastric Cardia Cancer-A Comparative Study with Laparotomy and Laparoscopy-Assisted Surgery. ( 27858518 )
2017
12
CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study. ( 28002320 )
2016
13
A specific role of endoscopic ultrasonography for therapeutic decision-making in patients with gastric cardia cancer. ( 26715019 )
2016
14
The clinical utility of RFA in esophageal and cardia cancer patients with severe malignant obstruction. ( 26293899 )
2016
15
Serum selenium level in patients with gastric non-cardia cancer and functional dyspepsia. ( 25999620 )
2015
16
Helicobacter pylori infection and gastric cardia cancer in Chaoshan region. ( 25038396 )
2014
17
Pleural Metastasis as Initial Presentation of Occult Gastric Cardia Cancer: A Possible Role of PET-CT in Diagnosis. ( 25036578 )
2014
18
Status and prognosis of lymph node metastasis in patients with cardia cancer - a systematic review. ( 24953457 )
2014
19
Patrilineal background of esophageal cancer and gastric cardia cancer patients in a Chaoshan high-risk area in China. ( 24339953 )
2013
20
A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. ( 23803050 )
2013
21
Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer. ( 22914345 )
2013
22
Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. ( 22967119 )
2012
23
Gastric cardia cancer: how much is it from fat? ( 22915196 )
2012
24
Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer. ( 22580669 )
2012
25
Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. ( 22317953 )
2012
26
Is cardia cancer aetiologically different from distal stomach cancer? ( 21150780 )
2011
27
The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. ( 21792941 )
2011
28
Impact of concentration of oesophageal and gastric cardia cancer surgery on long-term population-based survival. ( 21509748 )
2011
29
Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. ( 21184266 )
2011
30
The prognosis of gastric cardia cancer after R0 resection. ( 19837398 )
2010
31
A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area. ( 20603233 )
2010
32
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. ( 20699381 )
2010
33
En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection. ( 18657491 )
2009
34
An orthotopic nude mouse model for preclinical research of gastric cardia cancer. ( 18825389 )
2009
35
Nurse-led follow-up of patients after oesophageal or gastric cardia cancer surgery: a randomised trial. ( 19066612 )
2009
36
Video: minimally invasive Ivor-Lewis esophagogastrectomy for gastric cardia cancer. ( 19452220 )
2009
37
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. ( 17965056 )
2008
38
Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. ( 18287862 )
2008
39
Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. ( 18434132 )
2008
40
A rising trend of gastric cardia cancer in Gansu Province of China. ( 18501504 )
2008
41
Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer. ( 18523774 )
2008
42
Risk factors for malnutrition after oesophageal and cardia cancer surgery. ( 18844265 )
2008
43
Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction. ( 19120911 )
2008
44
New design esophageal stents for the palliation of dysphagia from esophageal or gastric cardia cancer: a randomized trial. ( 17900325 )
2008
45
Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer. ( 17492381 )
2008
46
Detection of distant metastases in patients with oesophageal or gastric cardia cancer: a diagnostic decision analysis. ( 17848957 )
2007
47
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. ( 17638920 )
2007
48
Ultrasound, computed tomography, or the combination for the detection of supraclavicular lymph nodes in patients with esophageal or gastric cardia cancer: a comparative study. ( 17455243 )
2007
49
Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. ( 17383456 )
2007
50
Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. ( 17317788 )
2007

Variations for Cardia Cancer

Expression for Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for Cardia Cancer

Pathways related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 CYP1A1 GSTM1 GSTP1 GSTT1 MTRR
2
Show member pathways
12.62 CYP1A1 GSTM1 GSTP1 GSTT1
3
Show member pathways
12.53 GSTM1 GSTP1 GSTT1 TP53
4 12.53 GSTM1 GSTP1 GSTT1 MDM2 TP53
5
Show member pathways
12.46 MDM2 PARP1 TP53 XRCC1
6 12.13 GSTP1 MDM2 TP53 TYMS XRCC1
7
Show member pathways
12.11 GSTM1 GSTP1 GSTT1
8 12.09 MDM2 PLCE1 TP53
9
Show member pathways
11.85 MTHFR MTRR TYMS
10
Show member pathways
11.81 PARP1 PLCE1 TP53
11 11.81 GSTM1 GSTP1 GSTT1 TP53
12 11.74 MDM2 PLCE1 TP53
13 11.7 MDM2 PLCE1 TP53
14 11.55 MDM2 TP53 TYMS
15
Show member pathways
11.35 CYP1A1 GSTM1 GSTP1 GSTT1
16
Show member pathways
11.16 CYP1A1 GSTM1
17 11.12 MDM2 TP53
18 11.1 MTHFR TYMS
19 11.09 MDM2 TP53
20 11.05 PARP1 PLCE1 TP53
21 10.96 GSTM1 GSTP1 GSTT1
22 10.92 MDM2 TP53
23
Show member pathways
10.91 MDM2 TP53
24 10.88 GSTM1 GSTP1 GSTT1 MDM2 TP53
25 10.69 GSTP1 GSTT1
26 10.64 CYP1A1 GSTM1 GSTP1 GSTT1

GO Terms for Cardia Cancer

Cellular components related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.28 GSTM1 GSTP1 GSTT1 MDM2 MTHFR MTRR

Biological processes related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.74 CYP1A1 MTHFR XRCC1
2 response to amino acid GO:0043200 9.6 GSTP1 MTHFR
3 negative regulation of fibroblast proliferation GO:0048147 9.59 GSTP1 TP53
4 response to gamma radiation GO:0010332 9.58 PARP1 TP53
5 cellular response to gamma radiation GO:0071480 9.58 MDM2 TP53
6 glutathione metabolic process GO:0006749 9.58 GSTM1 GSTP1 GSTT1
7 folic acid metabolic process GO:0046655 9.56 MTHFR MTRR
8 positive regulation of protein export from nucleus GO:0046827 9.55 MDM2 TP53
9 response to drug GO:0042493 9.55 CYP1A1 MDM2 MTHFR TYMS XRCC1
10 response to vitamin A GO:0033189 9.54 CYP1A1 TYMS
11 methionine biosynthetic process GO:0009086 9.52 MTHFR MTRR
12 tetrahydrofolate interconversion GO:0035999 9.51 MTHFR TYMS
13 tetrahydrofolate metabolic process GO:0046653 9.49 MTHFR TYMS
14 homocysteine metabolic process GO:0050667 9.48 MTHFR MTRR
15 response to folic acid GO:0051593 9.46 MTHFR TYMS
16 methionine metabolic process GO:0006555 9.43 MTHFR MTRR
17 response to antibiotic GO:0046677 9.43 CYP1A1 MDM2 TP53
18 cellular response to actinomycin D GO:0072717 9.37 MDM2 TP53
19 positive regulation of single strand break repair GO:1903518 9.32 PARP1 XRCC1
20 glutathione derivative biosynthetic process GO:1901687 9.13 GSTM1 GSTP1 GSTT1
21 response to toxic substance GO:0009636 8.92 CYP1A1 GSTP1 MDM2 TYMS

Molecular functions related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.43 MDM2 PARP1 TP53
2 FAD binding GO:0071949 9.37 MTHFR MTRR
3 glutathione peroxidase activity GO:0004602 9.32 GSTP1 GSTT1
4 enzyme binding GO:0019899 9.17 CYP1A1 GSTM1 MDM2 PARP1 PLCE1 TP53
5 glutathione binding GO:0043295 9.16 GSTM1 GSTP1
6 glutathione transferase activity GO:0004364 9.13 GSTM1 GSTP1 GSTT1

Sources for Cardia Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....