MCID: CRD005
MIFTS: 37

Cardia Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cardia Cancer

MalaCards integrated aliases for Cardia Cancer:

Name: Cardia Cancer 12 15
Malignant Neoplasm of Cardia of Stomach 12
Ca Cardia - Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10548
ICD9CM 34 151.0
SNOMED-CT 67 93738008
ICD10 32 C16.0
UMLS 70 C0153417

Summaries for Cardia Cancer

MalaCards based summary : Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to gastric cardia carcinoma and gastrointestinal carcinoma. An important gene associated with Cardia Cancer is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Drug metabolism - cytochrome P450 and Pathways in cancer. The drugs Acetaminophen and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and thyroid, and related phenotypes are growth/size/body region and neoplasm

Related Diseases for Cardia Cancer

Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 gastric cardia carcinoma 30.3 XRCC1 MTHFR
2 gastrointestinal carcinoma 30.3 TYMS TP53 KRT19
3 gastric cardia adenocarcinoma 29.8 SLC52A3 SEMA3B-AS1 PLCE1 MTHFR
4 squamous cell carcinoma 29.7 XRCC1 TP53 KRT19 GSTP1 CYP1A1
5 lung cancer susceptibility 3 29.5 TP53 PARP1 MIR17 KRT19 CYP1A1
6 gastric cancer 29.2 XRCC1 TYMS TP53 S100A8 MTHFR MIR17
7 esophageal cancer 28.8 XRCC1 TYMS TP53 SLC52A3 PLCE1 MTHFR
8 hemifacial spasm 10.4 TYMS MTHFR
9 ring chromosome 7 10.4 TP53 MDM2
10 nondisjunction 10.4 MTRR MTHFR
11 actinic cheilitis 10.4 TP53 MDM2
12 esophagus verrucous carcinoma 10.4 TP53 MDM2
13 hearing loss, noise-induced 10.3 GSTT1 GSTM1
14 undifferentiated embryonal sarcoma of the liver 10.3 TP53 MDM2
15 pediatric liposarcoma 10.3 TP53 MDM2
16 methotrexate toxicity 10.3 TYMS MTRR MTHFR
17 periosteal osteogenic sarcoma 10.3 TP53 MDM2
18 thyroid tumor 10.3 GSTT1 GSTM1
19 multiple chemical sensitivity 10.3 MTHFR GSTP1 GSTM1
20 maxillary sinus adenocarcinoma 10.3 TP53 MDM2
21 helicobacter pylori infection 10.3
22 dysphagia 10.3
23 trimethoprim allergy 10.3 GSTM1 CYP2E1
24 mucositis 10.3 XRCC1 TYMS MTHFR
25 exfoliation syndrome 10.3 MTHFR GSTP1 GSTM1
26 female breast cancer 10.3 XRCC1 TP53 CYP1A1
27 peripheral osteosarcoma 10.3 TP53 MDM2
28 acetaminophen metabolism 10.3 GSTP1 CYP2E1 CYP1A1
29 oral leukoplakia 10.3 XRCC1 GSTT1 GSTM1
30 adenocarcinoma 10.3
31 beta-thalassemia major 10.3 MTHFR GSTT1 GSTM1
32 oral submucous fibrosis 10.3 TP53 GSTM1 CYP1A1
33 soft tissue sarcoma 10.3 TP53 MDM2
34 alcoholic pancreatitis 10.3 GSTP1 GSTM1 CYP2E1
35 senile cataract 10.3 XRCC1 GSTT1 GSTM1
36 parameningeal embryonal rhabdomyosarcoma 10.3 TP53 MDM2
37 leukoplakia 10.2 GSTT1 GSTM1 CYP1A1
38 asbestosis 10.2 GSTT1 GSTP1 GSTM1
39 isolated cleft lip 10.2 GSTT1 GSTM1
40 diffuse gastric cancer 10.2 GSTT1 GSTP1 GSTM1
41 paratesticular lipoma 10.2 MDM2 KRT19
42 lipoma of spermatic cord 10.2 MDM2 KRT19
43 fallopian tube disease 10.2 TP53 TLR4 MTRR
44 anus disease 10.2 TP53 TLR4 MTRR
45 rectal disease 10.2 TP53 TLR4 MTRR
46 xeroderma pigmentosum, complementation group a 10.2 XRCC1 TP53 PARP1
47 toxic oil syndrome 10.2 GSTM1 CYP1A1
48 pleural cancer 10.2 TYMS TP53 MIR17
49 eccrine sweat gland cancer 10.2 TP53 KRT19
50 sporadic breast cancer 10.2 XRCC1 TP53 PARP1

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to Cardia Cancer

Symptoms & Phenotypes for Cardia Cancer

MGI Mouse Phenotypes related to Cardia Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.8 CYP1A1 CYP2E1 GSTP1 KRT19 MDM2 MTHFR
2 neoplasm MP:0002006 9.23 CYP2E1 GSTP1 KRT19 MDM2 PLCE1 TLR4

Drugs & Therapeutics for Cardia Cancer

Drugs for Cardia Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2 Analgesics, Non-Narcotic
3 Analgesics
4 Antipyretics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Validation of Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet to Golden Standard, to Scintigraphy. A Pilot Study Completed NCT02158286
2 Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study Recruiting NCT02491840
3 Institut Paoli Calmettes Cardia Cancer Database Recruiting NCT02869477

Search NIH Clinical Center for Cardia Cancer

Genetic Tests for Cardia Cancer

Anatomical Context for Cardia Cancer

MalaCards organs/tissues related to Cardia Cancer:

40
Liver, Breast, Thyroid, Lymph Node, Spleen, T Cells, Bone

Publications for Cardia Cancer

Articles related to Cardia Cancer:

(show top 50) (show all 425)
# Title Authors PMID Year
1
Calcium channel blockers are associated with lower gastric cancer risk: A territory-wide study with propensity score analysis. 61
33152125 2021
2
A novel method for π-shaped esophagojejunostomy and double-tract reconstruction (DTR) as an alternative in totally laparoscopic or robotic proximal gastrectomy for treating upper third proximal early gastric cancer. 61
33576931 2021
3
Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies. 61
33554339 2021
4
Alcohol Consumption and Risk of Gastric Cancer: The Japan Collaborative Cohort Study. 61
31902851 2021
5
Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages. 61
33747975 2021
6
Is cardia cancer a special type of gastric cancer? A differential analysis of early cardia cancer and non-cardia cancer. 61
33758614 2021
7
Sex difference in the incidence of cardia and non-cardia gastric cancer in the United States, 1992-2014. 61
33308167 2020
8
Management of Tumor- and Nontumor-related Aorto-esophageal and Aorto-bronchial Fistulas. 61
33227472 2020
9
Influence of Tumor Location on Lymph Node Metastasis and Survival for Early Gastric Cancer: a Population-Based Study. 61
31463650 2020
10
Use of Acid-Suppressant Medications After Diagnosis Increases Mortality in a Subset of Gastrointestinal Cancer Patients. 61
31802383 2020
11
A transcriptomic study for identifying cardia- and non-cardia-specific gastric cancer prognostic factors using genetic algorithm-based methods. 61
32649057 2020
12
Development and validation of a nomogram to predict the prognosis of patients with gastric cardia cancer. 61
32839498 2020
13
Contrasting Prognostic Effects of Tumor-Infiltrating Lymphocyte Density in Cardia and Non-cardia Gastric Adenocarcinomas. 61
32596002 2020
14
Risk factors and prognosis of bone metastases in newly diagnosed gastric cancer. 61
32285687 2020
15
Somatic gene mutation signatures predict cancer type and prognosis in multiple cancers with pan-cancer 1000 gene panel. 61
31765737 2020
16
Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China. 61
32477927 2020
17
No Difference in Survival between Neo-Adjuvant Chemotherapy and Neo-Adjuvant Chemoradiation Therapy in Gastric Cardia Cancer Patients: A Contemporary View from the National Cancer Database. 61
31340206 2020
18
Effects of propofol on proliferation and apoptosis of cardia cancer cells via MAPK/ERK signaling pathway. 61
31957857 2020
19
Anthropometry, body fat composition and reproductive factors and risk of oesophageal and gastric cancer by subtype and subsite in the UK Biobank cohort. 61
33079929 2020
20
Changing Disparity of Gastric Cancer Incidence by Histological Types in US Race-Specific Populations. 61
33297759 2020
21
Five Serum Trace Elements Associated with Risk of Cardia and Noncardia Gastric Cancer in a Matched Case-Control Study. 61
32606938 2020
22
Ternary cancer comprising prostatic cancer, esophageal cancer, and gastric cardia cancer: a case report and literature review. 61
33425119 2020
23
Prognostic effect of different etiologies in patients with gastric cardia cancer. 61
31852158 2019
24
[A Case of Curative Resection of Locally Advanced Gastric Cancer after Nutrition Therapy and Chemotherapy with S-1 and Oxaliplatin Using Elemental Diet Tube]. 61
32156952 2019
25
[Efficacy of a novel fully covered radioactive stent for advanced esophageal and gastric cardia cancer: a retrospective controlled study]. 61
31874491 2019
26
Cardia cancer surgery: total gastrectomy versus proximal gastrectomy. 61
30657285 2019
27
Transhiatal distal esophagectomy for Siewert type II cardia cancer can be a treatment option in selected patients. 61
31005469 2019
28
Minimal length of proximal resection margin in adenocarcinoma of the esophagogastric junction: a systematic review of the literature. 61
31243725 2019
29
Diabetes Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-Wide Study With Propensity Score Analysis. 61
31296646 2019
30
Epstein Barr virus antibody reactivity and gastric cancer: A population-based case-control study. 61
31154081 2019
31
Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China. 61
31423187 2019
32
Risk and Predictors of Esophageal and Stomach Cancers in HIV-Infected Veterans: A Matched Cohort Study. 61
30939533 2019
33
Targeted regulation of miR-17-5p on TMOD1 promotes the development of cardia cancer. 61
31364131 2019
34
Survival Trends of Patients With Surgically Resected Gastric Cardia Cancer From 1988 to 2015: A Population-based Study in the United States. 61
31157623 2019
35
Estimation of Cost for Endoscopic Screening for Esophageal Cancer in a High-Risk Population in Rural China: Results from a Population-Level Randomized Controlled Trial. 61
30809788 2019
36
Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry. 61
30733056 2019
37
Obesity and cancer risk: Emerging biological mechanisms and perspectives. 61
30445141 2019
38
Analyses on K-ras mutations and fascin expression in patients with cardia cancer. 61
30675241 2019
39
PLCE1 Polymorphisms and Risk of Esophageal and Gastric Cancer in a Northwestern Chinese Population. 61
30931333 2019
40
Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer: a systematic review. 61
30988695 2019
41
Race/Ethnicity-, Socioeconomic Status-, and Anatomic Subsite-Specific Risks for Gastric Cancer. 61
30267713 2019
42
Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study. 61
30873873 2019
43
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report. 61
29166433 2019
44
Relationship between the Body Mass Index and Tumor Site Postoperative Complications and Prognosis in Gastric Adenocarcinoma. 61
30606340 2018
45
Robotic total gastrectomy with π-shaped esophagojejunostomy using a linear stapler as a novel technique. 61
30577805 2018
46
Gastric Cardia Cancer Masquerading as a Fundic Subepithelial Tumor. 61
29899434 2018
47
Chronological Changes in the Gastric Cancer Subsite in Akita, Japan: The Trends from the Data of a Hospital-Based Registration System. 61
30369514 2018
48
Risk of gastric cancer among patients with gastric intestinal metaplasia. 61
29707766 2018
49
Physical activity, sedentary behaviour and risk of oesophago-gastric cancer: A prospective cohort study within UK Biobank. 61
30288276 2018
50
Body fatness at a young age and risks of eight types of cancer: systematic review and meta-analysis of observational studies. 61
30047231 2018

Variations for Cardia Cancer

Expression for Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for Cardia Cancer

Pathways related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 GSTT1 GSTP1 GSTM1 CYP2E1 CYP1A1
2 12.63 TP53 MDM2 GSTT1 GSTP1 GSTM1
3 12.19 TP53 TLR4 PLCE1 MDM2
4 12.19 XRCC1 TYMS TP53 MDM2 GSTP1
5 12.05 TP53 TLR4 PLCE1 MDM2
6 11.81 TP53 GSTT1 GSTP1 GSTM1
7
Show member pathways
11.69 MDM2 CYP2E1 CYP1A1
8 11.64 TYMS TP53 MDM2
9
Show member pathways
11.53 TYMS TP53 MTHFR
10
Show member pathways
11.45 GSTT1 GSTP1 GSTM1 CYP2E1 CYP1A1
11 11.22 TP53 MDM2 GSTT1 GSTP1 GSTM1
12 10.9 GSTT1 GSTP1 GSTM1
13 10.73 GSTT1 GSTP1
14 10.4 GSTT1 GSTP1 GSTM1 CYP2E1 CYP1A1
15 10.36 MTHFR CYP2E1
16 10.18 GSTM1 CYP2E1

GO Terms for Cardia Cancer

Cellular components related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 TYMS TP53 TMOD1 TLR4 SLC52A3 S100A8

Biological processes related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.67 TYMS S100A8 GSTP1 CYP2E1
2 glutathione metabolic process GO:0006749 9.61 GSTT1 GSTP1 GSTM1
3 cardiac septum morphogenesis GO:0060411 9.59 TP53 MDM2
4 methionine biosynthetic process GO:0009086 9.58 MTRR MTHFR
5 tetrahydrofolate metabolic process GO:0046653 9.58 TYMS MTHFR
6 tetrahydrofolate interconversion GO:0035999 9.57 TYMS MTHFR
7 response to folic acid GO:0051593 9.56 TYMS MTHFR
8 hepoxilin biosynthetic process GO:0051122 9.55 GSTP1 GSTM1
9 homocysteine metabolic process GO:0050667 9.54 MTRR MTHFR
10 cellular response to UV-C GO:0071494 9.52 TP53 MDM2
11 heterocycle metabolic process GO:0046483 9.51 CYP2E1 CYP1A1
12 response to antibiotic GO:0046677 9.5 TP53 MDM2 CYP1A1
13 methionine metabolic process GO:0006555 9.49 MTRR MTHFR
14 lipid hydroxylation GO:0002933 9.48 CYP2E1 CYP1A1
15 mitochondrial DNA repair GO:0043504 9.46 TP53 PARP1
16 cellular response to actinomycin D GO:0072717 9.4 TP53 MDM2
17 glutathione derivative biosynthetic process GO:1901687 9.33 GSTT1 GSTP1 GSTM1
18 positive regulation of single strand break repair GO:1903518 9.26 XRCC1 PARP1
19 response to toxic substance GO:0009636 9.26 TYMS MDM2 GSTP1 CYP1A1
20 response to drug GO:0042493 9.17 XRCC1 TYMS TP53 MTHFR MDM2 CYP2E1

Molecular functions related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.23 XRCC1 TP53 PLCE1 PARP1 MDM2 GSTM1
2 glutathione binding GO:0043295 9.16 GSTP1 GSTM1
3 glutathione transferase activity GO:0004364 9.13 GSTT1 GSTP1 GSTM1

Sources for Cardia Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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