MCID: CRD005
MIFTS: 44

Cardia Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Cardia Cancer

MalaCards integrated aliases for Cardia Cancer:

Name: Cardia Cancer 12 15
Malignant Neoplasm of Cardia of Stomach 12
Ca Cardia - Stomach 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10548
ICD9CM 36 151.0
SNOMED-CT 69 93738008
ICD10 34 C16.0
UMLS 74 C0153417

Summaries for Cardia Cancer

MalaCards based summary : Cardia Cancer, also known as malignant neoplasm of cardia of stomach, is related to gastric cancer and esophageal cancer. An important gene associated with Cardia Cancer is MTHFR (Methylenetetrahydrofolate Reductase), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Oxaliplatin and Capecitabine have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and lymph node, and related phenotype is neoplasm.

Related Diseases for Cardia Cancer

Diseases related to Cardia Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 gastric cancer 29.5 GSTM1 GSTP1 GSTT1 MTHFR TP53 TYMS
2 esophageal cancer 28.0 CYP1A1 GSTM1 GSTP1 GSTT1 MDM2 PLCE1
3 hearing loss, noise-induced 10.3 GSTM1 GSTT1
4 hemifacial spasm 10.3 MTHFR TYMS
5 non-proliferative fibrocystic change of the breast 10.3 TP53 XRCC1
6 isolated cleft lip 10.3 GSTM1 GSTT1
7 oligoasthenoteratozoospermia 10.3 GSTM1 GSTP1
8 ring chromosome 7 10.2 MDM2 TP53
9 nondisjunction 10.2 MTHFR MTRR
10 zika virus infection 10.2 MDM2 TP53
11 actinic cheilitis 10.2 MDM2 TP53
12 cheilitis 10.2 MDM2 TP53
13 sclerosing liposarcoma 10.2 MDM2 TP53
14 lip cancer 10.2 MDM2 TP53
15 arteritic anterior ischemic optic neuropathy 10.2 GSTM1 GSTT1 MTHFR
16 ischemic optic neuropathy 10.2 GSTM1 GSTT1 MTHFR
17 sapho syndrome 10.2 MDM2 TP53
18 senile cataract 10.2 GSTM1 GSTT1 XRCC1
19 gastric cardia carcinoma 10.2 MTHFR TYMS XRCC1
20 periosteal osteogenic sarcoma 10.2 MDM2 TP53
21 oral leukoplakia 10.2 GSTM1 TP53 XRCC1
22 diffuse gastric cancer 10.1 GSTM1 GSTP1 GSTT1
23 asbestosis 10.1 GSTM1 GSTP1 GSTT1
24 mucositis 10.1 MTHFR TYMS XRCC1
25 gliomatosis cerebri 10.1 MDM2 TP53
26 soft tissue sarcoma 10.1 MDM2 TP53
27 dedifferentiated liposarcoma 10.1 MDM2 TP53
28 small cell sarcoma 10.1 MDM2 TP53
29 laryngeal disease 10.1 GSTM1 GSTT1 TP53
30 myxosarcoma 10.1 MDM2 TP53
31 helicobacter pylori infection 10.1
32 bladder disease 10.1 GSTM1 GSTT1 TP53
33 maxillary cancer 10.1 TP53 TYMS
34 basal cell carcinoma 10.0 GSTM1 GSTT1 TP53
35 toxic oil syndrome 10.0 CYP1A1 GSTM1
36 gastroschisis 10.0 CYP1A1 MTHFR
37 verrucous carcinoma 10.0 MDM2 TP53
38 adenocarcinoma 10.0
39 gastric cardia adenocarcinoma 10.0
40 dysphagia 10.0
41 embryonal sarcoma 10.0 MDM2 TP53
42 xeroderma pigmentosum, complementation group d 10.0 GSTM1 GSTP1 GSTT1 XRCC1
43 neural tube defects, folate-sensitive 10.0 MTHFR MTRR
44 gastrointestinal stromal tumor 10.0 MTHFR MTRR TP53
45 leukoplakia 10.0 CYP1A1 GSTM1 GSTT1
46 childhood leukemia 10.0 CYP1A1 MTHFR TP53
47 mutagen sensitivity 10.0 GSTM1 GSTT1 TP53 XRCC1
48 oral submucous fibrosis 10.0 CYP1A1 GSTM1 GSTT1
49 squamous cell carcinoma, head and neck 9.9 GSTM1 GSTP1 GSTT1 TP53
50 breast disease 9.9 CYP1A1 TP53 XRCC1

Graphical network of the top 20 diseases related to Cardia Cancer:



Diseases related to Cardia Cancer

Symptoms & Phenotypes for Cardia Cancer

MGI Mouse Phenotypes related to Cardia Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 CYP2E1 MDM2 PLCE1 TP53 XRCC1

Drugs & Therapeutics for Cardia Cancer

Drugs for Cardia Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 1, Phase 2 61825-94-3 6857599 5310940 9887054 43805
2
Capecitabine Approved, Investigational Phase 2,Phase 1 154361-50-9 60953
3
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
4
Carboplatin Approved Phase 1, Phase 2 41575-94-4 38904 10339178 498142
5
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
6
Fluorouracil Approved Phase 1, Phase 2,Phase 2 51-21-8 3385
7
Levoleucovorin Approved, Investigational Phase 1, Phase 2 68538-85-2
8
leucovorin Approved Phase 1, Phase 2,Phase 2 58-05-9 6006 143
9
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
10
Pertuzumab Approved Phase 2 380610-27-5, 145040-37-5 2540
11
Trastuzumab Approved, Investigational Phase 2 180288-69-1 9903
12
Calcium Approved, Nutraceutical Phase 1, Phase 2 7440-70-2 271
13
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 59-30-3 6037
14 Antimetabolites Phase 1, Phase 2,Phase 2
15 Nutrients Phase 1, Phase 2,Not Applicable
16 Trace Elements Phase 1, Phase 2,Not Applicable
17 Antimetabolites, Antineoplastic Phase 1, Phase 2,Phase 2
18 Micronutrients Phase 1, Phase 2,Not Applicable
19 Bone Density Conservation Agents Phase 1, Phase 2
20 Antidotes Phase 1, Phase 2
21 Hematinics Phase 1, Phase 2
22 Hormones Phase 1, Phase 2
23 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
24 Vitamin B Complex Phase 1, Phase 2
25 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
26 Vitamins Phase 1, Phase 2
27 Immunologic Factors Phase 1, Phase 2,Phase 2
28 Albumin-Bound Paclitaxel Phase 1, Phase 2
29 Antimitotic Agents Phase 1, Phase 2
30 Vitamin B9 Phase 1, Phase 2
31 Calcium, Dietary Phase 1, Phase 2
32 Folate Phase 1, Phase 2
33 Antineoplastic Agents, Phytogenic Phase 1, Phase 2
34 Protective Agents Phase 1, Phase 2
35
Epirubicin Approved Phase 1 56420-45-2 41867
36
Azacitidine Approved, Investigational Phase 1 320-67-2 9444
37 Anti-Bacterial Agents Phase 1
38 Topoisomerase Inhibitors Phase 1
39 Antibiotics, Antitubercular Phase 1
40
Acetaminophen Approved 103-90-2 1983
41
Iodine Approved, Investigational Not Applicable 7553-56-2 807
42
Sulfasalazine Approved 599-79-1 5353980 5359476
43
Octreotide Approved, Investigational 83150-76-9 6400441 383414
44
Somatostatin Approved, Investigational 38916-34-6, 51110-01-1 53481605
45 Analgesics, Non-Narcotic
46 Analgesics
47 Antipyretics
48 Peripheral Nervous System Agents
49 Anti-Infective Agents, Local Not Applicable
50 Lugol's solution Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Pembrolizumab, Combination Chemotherapy, and Radiation Therapy Before Surgery in Treating Adult Patients With Locally Advanced Gastroesophageal Junction or Gastric Cardia Cancer That Can Be Removed by Surgery Recruiting NCT02730546 Phase 1, Phase 2 Carboplatin;Fluorouracil;Leucovorin Calcium;Oxaliplatin;Paclitaxel
2 Neoadjuvant Study Using Trastuzumab or Trastuzumab With Pertuzumab in Gastric or Gastroesophageal Junction Adenocarcinoma Recruiting NCT02205047 Phase 2 Cisplatin;5-fluorouracil or Capecitabine;Trastuzumab;Pertuzumab
3 Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy for Resectable Esophageal Cancer Completed NCT01386346 Phase 1 Azacitidine;Oxaliplatin;Epirubicin;Capecitabine
4 Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer Unknown status NCT03032224
5 Quality of Life With Esophageal Stent Trial Unknown status NCT01044511 Not Applicable
6 Mediastinal Microdialysis in Patients With Oesophageal or Cardia Cancer Treated by Resection Completed NCT00686569
7 Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet Completed NCT02158286
8 Endoscopic Screening on Esophageal Cancer Completed NCT02094105 Not Applicable
9 Institut Paoli Calmettes Cardia Cancer Database Recruiting NCT02869477
10 Biomoleculars Markers of Sensitivity to Pre- and Post-operative Chemotherapy of Gastric and Cardia Adenocarcinomas: a Pilot Study Recruiting NCT02491840 Not Applicable
11 Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery Enrolling by invitation NCT03734627 Octreotide Acetate;Saline Solution;Paracetamol;Sulfasalazine

Search NIH Clinical Center for Cardia Cancer

Genetic Tests for Cardia Cancer

Anatomical Context for Cardia Cancer

MalaCards organs/tissues related to Cardia Cancer:

42
Bone, T Cells, Lymph Node, Lung, Heart, Spleen

Publications for Cardia Cancer

Articles related to Cardia Cancer:

(show top 50) (show all 85)
# Title Authors Year
1
Comparisons between 2 surgeries for cardia cancer: total gastrectomy vs. proximal gastrectomy. ( 30657285 )
2019
2
Analyses on K-ras mutations and fascin expression in patients with cardia cancer. ( 30675241 )
2019
3
A case report of cardia cancer complicated with idiopathic muscular hypertrophy of the oesophagus treated with thoracoscopic surgery. ( 29067940 )
2018
4
Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population. ( 29670922 )
2018
5
18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study. ( 29743108 )
2018
6
Gastric Cardia Cancer Masquerading as a Fundic Subepithelial Tumor. ( 29899434 )
2018
7
Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer. ( 28293089 )
2017
8
Three United Laparoscopic Surgery for the Treatment of Gastric Cardia Cancer-A Comparative Study with Laparotomy and Laparoscopy-Assisted Surgery. ( 27858518 )
2017
9
Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China. ( 28319273 )
2017
10
Hypoglycemia caused by co-secretion of insulin from lung tumor and cardia cancer: first case report. ( 29166433 )
2017
11
A specific role of endoscopic ultrasonography for therapeutic decision-making in patients with gastric cardia cancer. ( 26715019 )
2016
12
CA125 is a potential biomarker to predict surgically incurable gastric and cardia cancer: A retrospective study. ( 28002320 )
2016
13
The clinical utility of RFA in esophageal and cardia cancer patients with severe malignant obstruction. ( 26293899 )
2015
14
Serum selenium level in patients with gastric non-cardia cancer and functional dyspepsia. ( 25999620 )
2015
15
Pleural Metastasis as Initial Presentation of Occult Gastric Cardia Cancer: A Possible Role of PET-CT in Diagnosis. ( 25036578 )
2014
16
Status and prognosis of lymph node metastasis in patients with cardia cancer - a systematic review. ( 24953457 )
2014
17
Helicobacter pylori infection and gastric cardia cancer in Chaoshan region. ( 25038396 )
2014
18
A population-based case-control study on risk factors for gastric cardia cancer in rural areas of Linzhou. ( 23803050 )
2013
19
Diverging trends in the incidence of reflux-related and Helicobacter pylori-related gastric cardia cancer. ( 22914345 )
2013
20
Patrilineal background of esophageal cancer and gastric cardia cancer patients in a chaoshan high-risk area in china. ( 24339953 )
2013
21
Increased incidence and survival for oesophageal cancer but not for gastric cardia cancer in the Netherlands. ( 22317953 )
2012
22
Combined splenectomy does not improve survival in radical total gastrectomy for advanced gastric cardia cancer. ( 22580669 )
2012
23
Prevalence and clinicopathologic characteristics of gastric cardia cancer in South Korea. ( 22967119 )
2012
24
Gastric cardia cancer: how much is it from fat? ( 22915196 )
2012
25
Impact of concentration of oesophageal and gastric cardia cancer surgery on long-term population-based survival. ( 21509748 )
2011
26
Helicobacter pylori infection and gastric cardia cancer: systematic review and meta-analysis. ( 21184266 )
2011
27
Is cardia cancer aetiologically different from distal stomach cancer? ( 21150780 )
2011
28
The ratio of intra-tumoral regulatory T cells (Foxp3+)/helper T cells (CD4+) is a prognostic factor and associated with recurrence pattern in gastric cardia cancer. ( 21792941 )
2011
29
The prognosis of gastric cardia cancer after R0 resection. ( 19837398 )
2010
30
A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. ( 20699381 )
2010
31
A positive family history of esophageal/gastric cardia cancer with gastric cardia adenocarcinoma is associated with a younger age at onset and more likely with another synchronous esophageal/gastric cardia cancer in a Chinese high-risk area. ( 20603233 )
2010
32
Nurse-led follow-up of patients after oesophageal or gastric cardia cancer surgery: a randomised trial. ( 19066612 )
2009
33
An orthotopic nude mouse model for preclinical research of gastric cardia cancer. ( 18825389 )
2009
34
En bloc resection of cardia cancer and lipoma with endoscopic submucosal dissection. ( 18657491 )
2009
35
Video: minimally invasive Ivor-Lewis esophagogastrectomy for gastric cardia cancer. ( 19452220 )
2009
36
Risk factors for malnutrition after oesophageal and cardia cancer surgery. ( 18844265 )
2008
37
Subclassification of superficial cardia cancer in relation to the endoscopic esophagogastric junction. ( 19120911 )
2008
38
Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. ( 18287862 )
2008
39
Radiologist experience and CT examination quality determine metastasis detection in patients with esophageal or gastric cardia cancer. ( 18523774 )
2008
40
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer. ( 17965056 )
2008
41
A rising trend of gastric cardia cancer in Gansu Province of China. ( 18501504 )
2008
42
New design esophageal stents for the palliation of dysphagia from esophageal or gastric cardia cancer: a randomized trial. ( 17900325 )
2008
43
Patient demographics and lifestyle factors influencing long-term survival of oesophageal cancer and gastric cardia cancer in a nationwide study in Sweden. ( 18434132 )
2008
44
Critical role of Helicobacter pylori in the pattern of gastritis and carditis in residents of an area with high prevalence of gastric cardia cancer. ( 17492381 )
2008
45
Ultrasound, computed tomography, or the combination for the detection of supraclavicular lymph nodes in patients with esophageal or gastric cardia cancer: a comparative study. ( 17455243 )
2007
46
Detection of distant metastases in patients with oesophageal or gastric cardia cancer: a diagnostic decision analysis. ( 17848957 )
2007
47
Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer. ( 17383456 )
2007
48
Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. ( 17638920 )
2007
49
Spleen preservation in radical surgery for gastric cardia cancer. ( 17265118 )
2007
50
Two distinct aetiologies of cardia cancer; evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status. ( 17317788 )
2007

Variations for Cardia Cancer

Expression for Cardia Cancer

Search GEO for disease gene expression data for Cardia Cancer.

Pathways for Cardia Cancer

Pathways related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.81 CYP1A1 CYP2E1 GSTM1 GSTP1 GSTT1 MTHFR
2
Show member pathways
12.93 CYP1A1 CYP2E1 GSTM1 GSTP1 GSTT1 MTRR
3 12.56 GSTM1 GSTP1 GSTT1 MDM2 TP53
4
Show member pathways
12.54 GSTM1 GSTP1 GSTT1 TP53
5
Show member pathways
12.53 CYP1A1 CYP2E1 GSTM1 GSTP1 GSTT1
6
Show member pathways
12.15 MTHFR MTRR TP53
7 12.13 GSTP1 MDM2 TP53 TYMS XRCC1
8
Show member pathways
12.11 GSTM1 GSTP1 GSTT1
9 12.1 MDM2 PLCE1 TP53
10
Show member pathways
11.89 MTHFR MTRR TYMS
11 11.81 GSTM1 GSTP1 GSTT1 TP53
12 11.79 MDM2 PLCE1 TP53
13 11.76 MDM2 PLCE1 TP53
14
Show member pathways
11.7 CYP1A1 CYP2E1 MDM2
15 11.63 MDM2 TP53 TYMS
16
Show member pathways
11.45 CYP1A1 CYP2E1 GSTM1 GSTP1 GSTT1
17 11.22 GSTM1 GSTP1 GSTT1 MDM2 TP53
18
Show member pathways
11.16 CYP1A1 GSTM1
19 11.13 MDM2 TP53
20 11.1 MTHFR TYMS
21 11.1 MDM2 TP53
22 10.96 GSTM1 GSTP1 GSTT1
23 10.93 MDM2 TP53
24
Show member pathways
10.93 MDM2 TP53
25 10.73 GSTP1 GSTT1
26 10.4 CYP2E1 MTHFR
27 10.4 CYP1A1 CYP2E1 GSTM1 GSTP1 GSTT1
28 10.26 CYP2E1 GSTM1

GO Terms for Cardia Cancer

Cellular components related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.28 GSTM1 GSTP1 GSTT1 MDM2 MTHFR MTRR

Biological processes related to Cardia Cancer according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.77 CYP1A1 MTHFR XRCC1
2 response to ethanol GO:0045471 9.71 CYP2E1 GSTP1 TYMS
3 response to amino acid GO:0043200 9.62 GSTP1 MTHFR
4 negative regulation of fibroblast proliferation GO:0048147 9.61 GSTP1 TP53
5 cellular response to gamma radiation GO:0071480 9.61 MDM2 TP53
6 drug metabolic process GO:0017144 9.59 CYP1A1 CYP2E1
7 long-chain fatty acid biosynthetic process GO:0042759 9.58 CYP1A1 CYP2E1
8 epoxygenase P450 pathway GO:0019373 9.58 CYP1A1 CYP2E1
9 folic acid metabolic process GO:0046655 9.57 MTHFR MTRR
10 positive regulation of protein export from nucleus GO:0046827 9.56 MDM2 TP53
11 response to vitamin A GO:0033189 9.55 CYP1A1 TYMS
12 glutathione metabolic process GO:0006749 9.54 GSTM1 GSTP1 GSTT1
13 methionine biosynthetic process GO:0009086 9.52 MTHFR MTRR
14 tetrahydrofolate interconversion GO:0035999 9.51 MTHFR TYMS
15 tetrahydrofolate metabolic process GO:0046653 9.49 MTHFR TYMS
16 homocysteine metabolic process GO:0050667 9.48 MTHFR MTRR
17 response to folic acid GO:0051593 9.46 MTHFR TYMS
18 heterocycle metabolic process GO:0046483 9.43 CYP1A1 CYP2E1
19 response to antibiotic GO:0046677 9.43 CYP1A1 MDM2 TP53
20 methionine metabolic process GO:0006555 9.4 MTHFR MTRR
21 glutathione derivative biosynthetic process GO:1901687 9.33 GSTM1 GSTP1 GSTT1
22 cellular response to actinomycin D GO:0072717 9.32 MDM2 TP53
23 response to toxic substance GO:0009636 9.26 CYP1A1 GSTP1 MDM2 TYMS
24 response to drug GO:0042493 9.1 CYP1A1 CYP2E1 MDM2 MTHFR TYMS XRCC1

Molecular functions related to Cardia Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.73 CYP1A1 CYP2E1 MTHFR MTRR
2 oxygen binding GO:0019825 9.46 CYP1A1 CYP2E1
3 FAD binding GO:0071949 9.4 MTHFR MTRR
4 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.37 CYP1A1 CYP2E1
5 steroid hydroxylase activity GO:0008395 9.32 CYP1A1 CYP2E1
6 glutathione peroxidase activity GO:0004602 9.26 GSTP1 GSTT1
7 enzyme binding GO:0019899 9.17 CYP1A1 CYP2E1 GSTM1 MDM2 PLCE1 TP53
8 glutathione binding GO:0043295 9.16 GSTM1 GSTP1
9 glutathione transferase activity GO:0004364 9.13 GSTM1 GSTP1 GSTT1

Sources for Cardia Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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