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MCID: CRD119
MIFTS: 62

Cardiac Arrest

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Cardiac Arrest

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MalaCards integrated aliases for Cardiac Arrest:

Name: Cardiac Arrest 12 76 29 55 6 43 15 73
Cardiopulmonary Arrest 12 55 73
Circulatory Arrest 12 73
Heart Arrest 44

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 33


Sources

Summaries for Cardiac Arrest

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MedlinePlus : 43 The heart has an internal electrical system that controls the rhythm of the heartbeat. Problems can cause abnormal heart rhythms, called arrhythmias. There are many types of arrhythmia. During an arrhythmia, the heart can beat too fast, too slow, or it can stop beating. Sudden cardiac arrest (SCA) occurs when the heart develops an arrhythmia that causes it to stop beating. This is different than a heart attack, where the heart usually continues to beat but blood flow to the heart is blocked. There are many possible causes of SCA. They include coronary heart disease, physical stress, and some inherited disorders. Sometimes there is no known cause for the SCA. Without medical attention, the person will die within a few minutes. People are less likely to die if they have early defibrillation. Defibrillation sends an electric shock to restore the heart rhythm to normal. You should give cardiopulmonary resuscitation (CPR) to a person having SCA until defibrillation can be done. If you have had an SCA, an implantable cardiac defibrillator (ICD) reduces the chance of dying from a second SCA. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Cardiac Arrest, also known as cardiopulmonary arrest, is related to arrhythmogenic right ventricular cardiomyopathy and ventricular fibrillation, paroxysmal familial, 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Cardiac Arrest is PLN (Phospholamban), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Clonazepam and Valproic Acid have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and breast, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all.

Wikipedia : 76 Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively... more...

Sources

Related Diseases for Cardiac Arrest

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Diseases related to Cardiac Arrest via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 arrhythmogenic right ventricular cardiomyopathy 31.9 DSP PLN RYR2 SCN5A
2 ventricular fibrillation, paroxysmal familial, 1 31.4 DSP KCNQ1 RYR2 SCN5A TNNT2
3 cardiac conduction defect 30.9 DSP KCNQ1 MYBPC3 PLN RYR2 SCN5A
4 myocardial infarction 30.4 ACE ALB CKB S100B TNNT2
5 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 30.3 CALM1 CASQ2 DSP KCNQ1 RYR2 SCN5A
6 long qt syndrome 1 30.3 CALM1 CASQ2 DSP KCNQ1 RYR2 SCN5A
7 cardiac arrhythmia 30.0 KCNQ1 RYR2 SCN5A
8 arteries, anomalies of 29.9 ACE ALB TNNT2
9 long qt syndrome 29.6 CALM1 KCNQ1 MYBPC3 RYR2 SCN5A
10 catecholaminergic polymorphic ventricular tachycardia 29.5 CALM1 CASQ2 MYBPC3 RYR2 SCN5A TECRL
11 hypertrophic cardiomyopathy 29.1 ACE DSP MYBPC3 PLN RYR2 TNNT2
12 acute myocardial infarction 28.9 ACE CKB TNNT2
13 atrial fibrillation 28.8 ACE KCNQ1 MYBPC3 RYR2 SCN5A
14 left ventricular noncompaction 28.4 DSP KCNQ1 MYBPC3 RYR2 SCN5A TNNT2
15 atrial standstill 1 28.2 ACE DSP MYBPC3 PLN SCN5A SLC25A20
16 heart disease 27.2 ACE ALB DSP KCNQ1 MYBPC3 RYR2
17 dilated cardiomyopathy 26.0 ACE ALB DSP KCNQ1 MYBPC3 PLN
18 hypoxia 11.2
19 wolff-parkinson-white syndrome 11.2
20 orthostatic intolerance 11.2
21 pulmonary edema 11.2
22 anoxia 11.2
23 cerebral hypoxia 11.2
24 eclampsia 11.2
25 cyanide poisoning 11.2
26 cardiomyopathy, infantile histiocytoid 11.1
27 jervell and lange-nielsen syndrome 1 11.0
28 ventricular tachycardia, catecholaminergic polymorphic, 3 11.0
29 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.9 DSP RYR2
30 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.9 DSP RYR2
31 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.9 DSP RYR2
32 coronary artery dissection, spontaneous 10.8
33 ventricular tachycardia, catecholaminergic polymorphic, 2 10.8
34 ventricular tachycardia, catecholaminergic polymorphic, 4 10.8
35 ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness 10.8
36 sudden cardiac failure, infantile 10.8
37 sudden cardiac failure, alcohol-induced 10.8
38 myocarditis 10.8
39 arrhythmogenic right ventricular dysplasia, familial, 2 10.8 CASQ2 RYR2
40 idiopathic ventricular fibrillation, non brugada type 10.8 DPP6 SCN5A
41 paroxysmal ventricular fibrillation 10.8 DPP6 SCN5A
42 intracranial cysts 10.7 ENO2 S100B
43 bednar tumor 10.7 ENO2 S100B
44 epithelioid malignant peripheral nerve sheath tumor 10.7 ENO2 S100B
45 arrhythmogenic right ventricular dysplasia, familial, 9 10.6 DSP PLN RYR2
46 middle cerebral artery infarction 10.6 ENO2 S100B
47 plexiform schwannoma 10.6 DSP ENO2
48 ossifying fibromyxoid tumor 10.6 ENO2 S100B
49 head injury 10.5 ENO2 S100B
50 neonatal hypoxic and ischemic brain injury 10.5 CKB ENO2

Comorbidity relations with Cardiac Arrest via Phenotypic Disease Network (PDN): (show all 33)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Aortic Aneurysm Aortic Valve Disease 1
Bronchitis Cardiogenic Shock
Chronic Kidney Failure Chronic Myocardial Ischemia
Decubitus Ulcer Deficiency Anemia
Disseminated Intravascular Coagulation Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Intermediate Coronary Syndrome
Ischemic Heart Disease Kidney Disease
Mitral Valve Disease Ocular Motor Apraxia
Peripheral Vascular Disease Progressive Familial Heart Block, Type Ia
Protein-Energy Malnutrition Pulmonary Hypertension, Primary, 1
Respiratory Failure Sinoatrial Node Disease
Third-Degree Atrioventricular Block Tricuspid Valve Disease
Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Cardiac Arrest:



Diseases related to Cardiac Arrest
Sources

Symptoms & Phenotypes for Cardiac Arrest

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UMLS symptoms related to Cardiac Arrest:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Cardiac Arrest:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ACE CKB CYCS ENO2 KCNQ1 MYBPC3
2 cardiovascular system MP:0005385 9.96 ACE CASQ2 CYCS DSP KCNQ1 MYBPC3
3 growth/size/body region MP:0005378 9.9 CASQ2 CKB CYCS DSP ENO2 KCNQ1
4 muscle MP:0005369 9.61 ALB CASQ2 DSP KCNQ1 MYBPC3 RYR2
5 nervous system MP:0003631 9.32 TNNT2 CKB CYCS DPP6 DSP ENO2
Sources

Drugs & Therapeutics for Cardiac Arrest

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Drugs for Cardiac Arrest (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 736)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
2
Valproic Acid Approved, Investigational Phase 4,Not Applicable 99-66-1 3121
3
Lorazepam Approved Phase 4,Not Applicable 846-49-1 3958
4
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
5
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
6
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
7
Ticagrelor Approved Phase 4 274693-27-5 9871419
8
Meperidine Approved Phase 4 57-42-1 4058
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
11
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
12
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
13
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
14
Ofloxacin Approved Phase 4 82419-36-1 4583
15
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
16
Menthol Approved Phase 4,Phase 3,Not Applicable 2216-51-5 16666
17
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
18
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 772 46507594
19
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
20
Mannitol Approved, Investigational Phase 4,Phase 2 69-65-8 453 6251
21
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 10102-43-9 145068 160954
22
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Not Applicable 437-38-7 3345
23
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
24
Remifentanil Approved Phase 4,Phase 3,Not Applicable 132875-61-7 60815
25
Misoprostol Approved Phase 4,Phase 1 59122-46-2 5282381
26
Oxytocin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 50-56-6 439302 53477758
27
Dobutamine Approved Phase 4,Phase 3,Not Applicable 34368-04-2 36811
28
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
29
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-41-2 439260
30
Oxymetazoline Approved, Investigational Phase 4,Phase 3,Phase 2 1491-59-4 4636
31
Phenylephrine Approved Phase 4,Phase 3,Phase 2 59-42-7 6041
32
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
33
Ticlopidine Approved Phase 4 55142-85-3 5472
34
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 16590-41-3 5360515
35
Nifedipine Approved Phase 4,Phase 2 21829-25-4 4485
36
Ritodrine Approved, Investigational Phase 4 26652-09-5 33572
37
Atropine Approved, Vet_approved Phase 4,Phase 2 5908-99-6, 51-55-8 174174
38
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
39
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
40
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757
41 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 979-32-8
42
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
43
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
44
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
45
Polyestradiol phosphate Approved Phase 4,Phase 2,Phase 3 28014-46-2
46
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
47
Haloperidol Approved Phase 4,Phase 3 52-86-8 3559
48
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
49
Perphenazine Approved Phase 4,Phase 3 58-39-9 4748
50
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073

Interventional clinical trials:

(show top 50) (show all 1522)
# Name Status NCT ID Phase Drugs
1 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
2 Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest Unknown status NCT02367755 Phase 4 Propofol;Lorazepam
3 Sodium Bicarbonate in Cardiopulmonary Resuscitation Unknown status NCT01377337 Phase 4 sodium bicarbonate
4 Effects and Plasma Concentration of Ticagrelor, After Crushed and Non-crushed Intake, After Acute Coronary Syndrome Unknown status NCT02341729 Phase 4 ticagrelor
5 Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women Unknown status NCT01555671 Phase 4 Placebo;Meperidine
6 Early Feeding Following Ligation of Acute Bleeding Varices Unknown status NCT01287702 Phase 4
7 Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome Unknown status NCT00815100 Phase 4 Ivabradine;Placebo
8 IRIS : Use of Implantable Defibrillator in High-Risk Patients Early After Acute Myocardial Infarction Unknown status NCT00157768 Phase 4
9 Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts Unknown status NCT02341833 Phase 4 Sevoflurane
10 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
11 Arrhythmia Restart Prevention and RatE STabilization in Atrial Fibrillation Unknown status NCT00224341 Phase 4
12 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
13 Low Dose Prolonged Infusion of Tissue Type Plasminogen Activator Therapy in Massive Pulmonary Embolism Unknown status NCT02029456 Phase 4 25 mg Actilyse ( Boehringer Ingelheim, Germany) infusion in 6 hours
14 Ultrasound Guided Pectoral Nerve I and II Blocks in Multimodal Analgesia for Breast Surgery Unknown status NCT02672813 Phase 4
15 The Effect of Chest Tubes Using Active Clearance Technology® on the Incidence of Postoperative Atrial Fibrillation Unknown status NCT02808897 Phase 4
16 Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest Completed NCT02899507 Phase 4 Amoxicillin-Clavulanic acid
17 Continuous Chest Compressions vs AHA Standard CPR of 30:2 Completed NCT01372748 Phase 4
18 Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest Completed NCT00127907 Phase 4 epinephrine (1 mg/1 mL);arginine-vasopressin (40 UI/2 mL)
19 Comparing Therapeutic Hypothermia Using External and Internal Cooling for Post-Cardiac Arrest Patients Completed NCT00827957 Phase 4
20 Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study) Completed NCT00392639 Phase 4
21 Antiplatelet Therapy After Cardiac Arrest Completed NCT02224274 Phase 4 Clopidogrel;Ticagrelor
22 Trial of Different Hypothermia Temperatures in Patients Recovered From Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
23 COOL-Trial: Outcome With Invasive and Non-invasive Cooling After Cardiac Arrest Completed NCT00843297 Phase 4
24 Prevention of Acute Kidney Injury by Erythropoietin in Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4 recombinant human erythropoietin;saline
25 Cardiopulmonary Resuscitation Witnessing by a Relative Completed NCT01009606 Phase 4
26 Beating Versus Arrested Heart for Mitral Valve Replacement Completed NCT01641614 Phase 4
27 A Study of VIVITROL in the Prevention of Re-arrest and Re-incarceration Completed NCT01453374 Phase 4 VIVITROL 380mg
28 Quick ICD Study: Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary ? Completed NCT00180362 Phase 4
29 Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER) Completed NCT00101881 Phase 4
30 The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Completed NCT02953886 Phase 4
31 Multicenter Automatic Defibrillator Implantation Trial - Reduce Inappropriate Therapy Completed NCT00947310 Phase 4
32 Randomized Trial of Pulsatile vs Non Pulsatile Perfusion on Short Term Changes in Kidney Function Using an Intra-Aortic Ballooon Pump During Cardioplegic Arrest in Patients Undergoing Myocardial Reperfusion Completed NCT00454428 Phase 4
33 Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor Completed NCT03040752 Phase 4 Nifedipine 20 Mg;Ritodrine Oral Tablet
34 ISSUE3: International Study on Syncope of Uncertain Etiology 3 Completed NCT00359203 Phase 4
35 Atropine for Prevention of Dysrhythmias Caused by Percutaneous Ethanol Instillation for Hepatoma Therapy Completed NCT00575523 Phase 4 Atropine;Placebo
36 The ENIGMA II Trial:Nitrous Oxide Anaesthesia and Cardiac Morbidity After Major Surgery: a Randomised Controlled Trial Completed NCT00430989 Phase 4 Nitrous Oxide;Nitrous Oxide
37 Atorvastatin Versus Simvastatin In The Prevention Of Coronary Heart Disease (CHD) In Patients With Known CHD Completed NCT00159835 Phase 4 atorvastatin;simvastatin
38 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
39 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated Completed NCT01157351 Phase 4 paliperidone;risperidone;haloperidole;perphenazine;aripiprazole;quetiapine;paliperidone palmitate;olanzapine
40 Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades Completed NCT00644722 Phase 4
41 Fluvastatin in the Therapy of Acute Coronary Syndrome Completed NCT00171275 Phase 4 Fluvastatin
42 Heart Outcomes Prevention Evaluation-3 Completed NCT00468923 Phase 4 Candesartan/HCT;Rosuvastatin
43 Preventive and Therapeutic Proximal Sealants Completed NCT02338180 Phase 4
44 Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke Completed NCT00147602 Phase 4 atorvastatin
45 Steroids in Fulminant Hepatic Failure in the Pediatric Age Group Completed NCT02375867 Phase 4 prednisolone;methylprednisolone
46 Evaluation of Statin Mechanism Preventing Cardiovascular Disease by Post-hoc Analysis of Treating to New Targets Study Completed NCT03073863 Phase 4 Atorvastatin
47 CARDS Is Designed To Show If Lowering Cholesterol With Atorvastatin In Type 2 Diabetics Without CV Disease Reduces The Risk Of CV Events Completed NCT00327418 Phase 4 Atorvastatin
48 The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting Completed NCT03251599 Phase 4 Glyceryl trinitrate 0.2;Glyceryl trinitrate 0.5
49 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
50 Addition of Dexmedetomidine to Ropivacaine-induced Supraclavicular Block (ADRIB Trial) Completed NCT02630290 Phase 4 Ropivacaine;Ropivacaine + Dexmedetomidine

Search NIH Clinical Center for Cardiac Arrest

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: heart arrest

Sources

Genetic Tests for Cardiac Arrest

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Genetic tests related to Cardiac Arrest:

# Genetic test Affiliating Genes
1 Cardiac Arrest 29
Sources

Anatomical Context for Cardiac Arrest

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MalaCards organs/tissues related to Cardiac Arrest:

41
Heart, Brain, Breast, Lung, Testes, Kidney, Bone
Sources

Publications for Cardiac Arrest

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Articles related to Cardiac Arrest:

(show top 50) (show all 657)
# Title Authors Year
1
Expanded Criteria Donor-Related Hyperkalemia and Postreperfusion Cardiac Arrest During Liver Transplantation: A Case Report and Literature Review. ( 29967315 )
2018
2
Out-of-Hospital Cardiac Arrest in the Presence of Ischemic Heart Disease: What Is the Long-term Arrhythmic Risk After Revascularization? ( 29958725 )
2018
3
Outcomes and healthcare-associated costs one year after intensive care-treated cardiac arrest. ( 29958958 )
2018
4
Delphi Analysis of Science Gaps in the 2015 American Heart Association Cardiac Arrest Guidelines. ( 29960986 )
2018
5
The Use of ECMO for the Treatment of Refractory Cardiac Arrest or Postarrest Cardiogenic Shock Following In-Hospital Cardiac Arrest: A 10-Year Experience. ( 29303029 )
2018
6
"Resuscitation time bias"-A unique challenge for observational cardiac arrest research. ( 29425975 )
2018
7
Ocular bobbing/dipping after cardiac arrest may be a post-anoxic myoclonus. ( 29307541 )
2018
8
Successful Resuscitation with Extracorporeal Membrane Oxygenation in a Case with Prolonged Cardiac Arrest. ( 29976283 )
2018
9
Is Distance to the Nearest Registered Public Automated Defibrillator Associated with the Probability of Bystander Shock for Victims of Out-of-Hospital Cardiac Arrest? ( 29433603 )
2018
10
Activation of Sigma-1 Receptor by Cutamesine Attenuates Neuronal Apoptosis by Inhibiting Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in a Rat Model of Asphyxia Cardiac Arrest. ( 29424796 )
2018
11
Association Between Early Hyperoxia Exposure After Resuscitation from Cardiac Arrest and Neurological Disability: A Prospective Multi-Center Protocol-Directed Cohort Study. ( 29437118 )
2018
12
Non-invasive characterization of hemodynamics in adult out-of-hospital cardiac arrest patients soon after return of spontaneous circulation. ( 29425976 )
2018
13
Epidemiology of Pediatric Out-of-Hospital Cardiac Arrest at Schoola88- An Investigation of a Nationwide Registry in Japan. ( 29445066 )
2018
14
Looking for CO<sub>2</sub>: Exploring the Novel Finding of Low Respiratory Quotient After Cardiac Arrest. ( 29959139 )
2018
15
EEG Factors After Pediatric Cardiac Arrest. ( 29438177 )
2018
16
Severe metabolic acidosis after out-of-hospital cardiac arrest: risk factors and association with outcome. ( 29740777 )
2018
17
Survival after in-hospital cardiac arrest among cerebrovascular disease patients. ( 29789199 )
2018
18
Effects of dispatcher-assisted bystander cardiopulmonary resuscitation on neurological recovery in paediatric patients with out-of-hospital cardiac arrest based on the pre-hospital emergency medical service response time interval. ( 29960075 )
2018
19
Successful Treatment of Refractory Cardiac Arrest With I^-Blockade and Extracorporeal Life Support in a Pediatric Patient With Catecholaminergic Polymorphic Ventricular Tachycardia: A Case Report. ( 29634558 )
2018
20
The Role of Cranial Temperature in Neuroprotection by Sodium Hydrogen Sulfide After Cardiac Arrest in Mice. ( 29431591 )
2018
21
Variation in Sedation and Neuromuscular Blockade Regimens on Outcome After Cardiac Arrest. ( 29979225 )
2018
22
Protective effects of nicorandil against cerebral injury in a swine cardiac arrest model. ( 29977355 )
2018
23
Late heartbeat-evoked potentials are associated with survival after cardiac arrest. ( 29447999 )
2018
24
Design of DISCO-Direct or Subacute Coronary Angiography in Out-of-Hospital Cardiac Arrest study. ( 29447784 )
2018
25
Changes in left ventricular systolic and diastolic function on serial echocardiography after out-of-hospital cardiac arrest. ( 29438721 )
2018
26
Characteristics of Neighbourhoods with High Incidence of Out-of-Hospital Cardiac Arrest and Low Bystander Cardiopulmonary Resuscitation Rates in England. ( 29961881 )
2018
27
Effect of target temperature management at 32-34a8^A^C in cardiac arrest patients considering assessment by regional cerebral oxygen saturation: A multicenter retrospective cohort study. ( 29432783 )
2018
28
Sudden cardiac arrest during marathon training in a young adult with short QT syndrome. ( 29876509 )
2018
29
Dissociated Oxygen Consumption and Carbon Dioxide Production in the Post-Cardiac Arrest Rat: A Novel Metabolic Phenotype. ( 29959138 )
2018
30
Optimal platelet inhibition with cangrelor in comatose survivors of out-of-hospital cardiac arrest undergoing primary percutaneous coronary intervention. ( 29969644 )
2018
31
Atherothrombotic out-of hospital cardiac arrest: watch out for a second train. ( 29437817 )
2018
32
Survival after out-of-hospital cardiac arrest in nursing homes - A nationwide study. ( 29425977 )
2018
33
Cardiac arrest and ventricular arrhythmia in adults with Ebstein anomaly and left ventricular non-compaction. ( 29305187 )
2018
34
Cyanide poisoning is a possible cause of cardiac arrest among fire victims, and empiric antidote treatment may improve outcomes. ( 29395761 )
2018
35
Perioperative Cardiac Arrest: Focus on Malignant Hyperthermia (MH): Erratum. ( 29517572 )
2018
36
Comparative Safety of Sulfonylureas and the Risk of Sudden Cardiac Arrest and Ventricular Arrhythmia. ( 29437823 )
2018
37
Stability of Early EEG Background Patterns After Pediatric Cardiac Arrest. ( 29443794 )
2018
38
Survival factors of hospitalized out-of-hospital cardiac arrest patients in Taiwan: A retrospective study. ( 29420551 )
2018
39
Perioperative Cardiac Arrest: Focus on Malignant Hyperthermia (MH). ( 29461317 )
2018
40
Quantitative Assessment of Pupillary Light Reflex for Early Prediction of Outcomes After Out-of-Hospital Cardiac Arrest: A Multicentre Prospective Observational Study. ( 29958957 )
2018
41
Novel relocation methods for automatic external defibrillator improve out-of-hospital cardiac arrest coverage under limited resources. ( 29414670 )
2018
42
Unusual congenital coronary artery anomaly in a young adult presenting as sudden cardiac arrest. ( 29691271 )
2018
43
Is atrial fibrillation a risk factor for in-hospital cardiac arrest?: a Swedish retrospective cohort study. ( 29961035 )
2018
44
Cardiac arrest related to anaesthesia in Williams-Beuren syndrome. ( 29246395 )
2017
45
Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population. ( 28943016 )
2017
46
Clinical Significance of J Waves in Patients Undergoing Therapeutic Hypothermia for Out-of-Hospital Cardiac Arrest. ( 27943347 )
2017
47
Cardiac arrest caused by rapidly increasing ascites in a patient with TAFRO syndrome: a case report. ( 29123888 )
2017
48
Rosuvastatin improves myocardial and neurological outcomes after asphyxial cardiac arrest and cardiopulmonary resuscitation in rats. ( 28076830 )
2017
49
Multistate 5-Year Initiative to Improve Care for Out-of-Hospital Cardiac Arrest: Primary Results From the HeartRescue Project. ( 28939711 )
2017
50
Quick epinephrine administration induces favorable neurological outcomes in out-of-hospital cardiac arrest patients. ( 28087097 )
2017
Sources

Variations for Cardiac Arrest

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ClinVar genetic disease variations for Cardiac Arrest:

6
(show top 50) (show all 60)
# Gene Variation Type Significance SNP ID Assembly Location
1 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh37 Chromosome 6, 118880200: 118880200
2 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh38 Chromosome 6, 118559037: 118559037
3 RYR2 NM_001035.2(RYR2): c.13759A> C (p.Ile4587Leu) single nucleotide variant Uncertain significance rs730880198 GRCh37 Chromosome 1, 237955600: 237955600
4 RYR2 NM_001035.2(RYR2): c.13759A> C (p.Ile4587Leu) single nucleotide variant Uncertain significance rs730880198 GRCh38 Chromosome 1, 237792300: 237792300
5 ANK2 NM_001148.4(ANK2): c.6206G> A (p.Arg2069His) single nucleotide variant Likely benign rs149645600 GRCh37 Chromosome 4, 114275980: 114275980
6 ANK2 NM_001148.4(ANK2): c.6206G> A (p.Arg2069His) single nucleotide variant Likely benign rs149645600 GRCh38 Chromosome 4, 113354824: 113354824
7 DSP NM_004415.3(DSP): c.2260G> A (p.Glu754Lys) single nucleotide variant Uncertain significance rs730880080 GRCh37 Chromosome 6, 7574448: 7574448
8 DSP NM_004415.3(DSP): c.2260G> A (p.Glu754Lys) single nucleotide variant Uncertain significance rs730880080 GRCh38 Chromosome 6, 7574215: 7574215
9 DSP NM_004415.3(DSP): c.2821C> T (p.Arg941Ter) single nucleotide variant Pathogenic/Likely pathogenic rs730880082 GRCh38 Chromosome 6, 7576986: 7576986
10 DSP NM_004415.3(DSP): c.2821C> T (p.Arg941Ter) single nucleotide variant Pathogenic/Likely pathogenic rs730880082 GRCh37 Chromosome 6, 7577219: 7577219
11 CACNA2D1 NM_000722.3(CACNA2D1): c.2264G> C (p.Ser755Thr) single nucleotide variant Benign/Likely benign rs151327713 GRCh38 Chromosome 7, 81969925: 81969925
12 CACNA2D1 NM_000722.3(CACNA2D1): c.2264G> C (p.Ser755Thr) single nucleotide variant Benign/Likely benign rs151327713 GRCh37 Chromosome 7, 81599241: 81599241
13 AKAP9 NM_005751.4(AKAP9): c.1099G> A (p.Val367Met) single nucleotide variant Likely benign rs138161478 GRCh37 Chromosome 7, 91630330: 91630330
14 AKAP9 NM_005751.4(AKAP9): c.1099G> A (p.Val367Met) single nucleotide variant Likely benign rs138161478 GRCh38 Chromosome 7, 92001016: 92001016
15 AKAP9 NM_005751.4(AKAP9): c.11378C> G (p.Ser3793Cys) single nucleotide variant Uncertain significance rs730880044 GRCh37 Chromosome 7, 91735039: 91735039
16 AKAP9 NM_005751.4(AKAP9): c.11378C> G (p.Ser3793Cys) single nucleotide variant Uncertain significance rs730880044 GRCh38 Chromosome 7, 92105725: 92105725
17 CACNB2 NM_201571.3(CACNB2): c.1122+3A> T single nucleotide variant Uncertain significance rs200174877 GRCh37 Chromosome 10, 18823159: 18823159
18 CACNB2 NM_201571.3(CACNB2): c.1122+3A> T single nucleotide variant Uncertain significance rs200174877 GRCh38 Chromosome 10, 18534230: 18534230
19 CACNB2 NM_201571.3(CACNB2): c.1558G> A (p.Gly520Ser) single nucleotide variant Likely pathogenic rs730880059 GRCh37 Chromosome 10, 18828312: 18828312
20 CACNB2 NM_201571.3(CACNB2): c.1558G> A (p.Gly520Ser) single nucleotide variant Likely pathogenic rs730880059 GRCh38 Chromosome 10, 18539383: 18539383
21 MYH6 NM_002471.3(MYH6): c.4713G> T (p.Lys1571Asn) single nucleotide variant Uncertain significance rs730880151 GRCh37 Chromosome 14, 23855770: 23855770
22 MYH6 NM_002471.3(MYH6): c.4713G> T (p.Lys1571Asn) single nucleotide variant Uncertain significance rs730880151 GRCh38 Chromosome 14, 23386561: 23386561
23 DSG2 NM_001943.4(DSG2): c.1063G> A (p.Ala355Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201046640 GRCh37 Chromosome 18, 29110998: 29110998
24 DSG2 NM_001943.4(DSG2): c.1063G> A (p.Ala355Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201046640 GRCh38 Chromosome 18, 31531035: 31531035
25 RYR2 NM_001035.2(RYR2): c.378T> A (p.Ser126Arg) single nucleotide variant Uncertain significance rs869025507 GRCh37 Chromosome 1, 237532902: 237532902
26 RYR2 NM_001035.2(RYR2): c.378T> A (p.Ser126Arg) single nucleotide variant Uncertain significance rs869025507 GRCh38 Chromosome 1, 237369602: 237369602
27 SCN5A NM_001099404.1(SCN5A): c.5075T> C (p.Phe1692Ser) single nucleotide variant Uncertain significance rs869025521 GRCh37 Chromosome 3, 38592788: 38592788
28 SCN5A NM_001099404.1(SCN5A): c.5075T> C (p.Phe1692Ser) single nucleotide variant Uncertain significance rs869025521 GRCh38 Chromosome 3, 38551297: 38551297
29 SCN5A NM_198056.2(SCN5A): c.559A> G (p.Thr187Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs869025517 GRCh38 Chromosome 3, 38620895: 38620895
30 SCN5A NM_198056.2(SCN5A): c.559A> G (p.Thr187Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs869025517 GRCh37 Chromosome 3, 38662386: 38662386
31 SLMAP NM_007159.4(SLMAP): c.1918+1G> A single nucleotide variant Uncertain significance rs869025527 GRCh38 Chromosome 3, 57912702: 57912702
32 SLMAP NM_007159.4(SLMAP): c.1918+1G> A single nucleotide variant Uncertain significance rs869025527 GRCh37 Chromosome 3, 57898429: 57898429
33 ANK2 NM_001148.4(ANK2): c.5509G> A (p.Ala1837Thr) single nucleotide variant Uncertain significance rs199527708 GRCh37 Chromosome 4, 114275283: 114275283
34 ANK2 NM_001148.4(ANK2): c.5509G> A (p.Ala1837Thr) single nucleotide variant Uncertain significance rs199527708 GRCh38 Chromosome 4, 113354127: 113354127
35 ANK2 NM_001148.4(ANK2): c.7458C> G (p.His2486Gln) single nucleotide variant Uncertain significance rs776972443 GRCh37 Chromosome 4, 114277232: 114277232
36 ANK2 NM_001148.4(ANK2): c.7458C> G (p.His2486Gln) single nucleotide variant Uncertain significance rs776972443 GRCh38 Chromosome 4, 113356076: 113356076
37 ANK2 NM_001148.4(ANK2): c.7577C> T (p.Ser2526Leu) single nucleotide variant Uncertain significance rs762909298 GRCh37 Chromosome 4, 114277351: 114277351
38 ANK2 NM_001148.4(ANK2): c.7577C> T (p.Ser2526Leu) single nucleotide variant Uncertain significance rs762909298 GRCh38 Chromosome 4, 113356195: 113356195
39 DSP NM_004415.3(DSP): c.2047G> A (p.Glu683Lys) single nucleotide variant Uncertain significance rs775181391 GRCh37 Chromosome 6, 7572218: 7572218
40 DSP NM_004415.3(DSP): c.2047G> A (p.Glu683Lys) single nucleotide variant Uncertain significance rs775181391 GRCh38 Chromosome 6, 7571985: 7571985
41 DSP NM_004415.3(DSP): c.7249G> T (p.Asp2417Tyr) single nucleotide variant Uncertain significance rs760501352 GRCh37 Chromosome 6, 7584744: 7584744
42 DSP NM_004415.3(DSP): c.7249G> T (p.Asp2417Tyr) single nucleotide variant Uncertain significance rs760501352 GRCh38 Chromosome 6, 7584511: 7584511
43 DPP6 NM_001039350.2(DPP6): c.847G> A (p.Ala283Thr) single nucleotide variant Uncertain significance rs770646362 GRCh38 Chromosome 7, 154772845: 154772845
44 DPP6 NM_001039350.2(DPP6): c.847G> A (p.Ala283Thr) single nucleotide variant Uncertain significance rs770646362 GRCh37 Chromosome 7, 154564555: 154564555
45 AKAP9 NM_005751.4(AKAP9): c.1067A> T (p.Asp356Val) single nucleotide variant Uncertain significance rs533277424 GRCh37 Chromosome 7, 91630298: 91630298
46 AKAP9 NM_005751.4(AKAP9): c.1067A> T (p.Asp356Val) single nucleotide variant Uncertain significance rs533277424 GRCh38 Chromosome 7, 92000984: 92000984
47 AKAP9 NM_005751.4(AKAP9): c.11276C> T (p.Pro3759Leu) single nucleotide variant Uncertain significance rs869025356 GRCh38 Chromosome 7, 92102772: 92102772
48 AKAP9 NM_005751.4(AKAP9): c.11276C> T (p.Pro3759Leu) single nucleotide variant Uncertain significance rs869025356 GRCh37 Chromosome 7, 91732086: 91732086
49 CACNB2 NM_000724.3(CACNB2): c.1429T> G (p.Ser477Ala) single nucleotide variant Uncertain significance rs869025371 GRCh38 Chromosome 10, 18539335: 18539335
50 CACNB2 NM_000724.3(CACNB2): c.1429T> G (p.Ser477Ala) single nucleotide variant Uncertain significance rs869025371 GRCh37 Chromosome 10, 18828264: 18828264
Sources

Expression for Cardiac Arrest

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Search GEO for disease gene expression data for Cardiac Arrest.
Sources

Pathways for Cardiac Arrest

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Pathways related to Cardiac Arrest according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.66 ALB CALM1 KCNQ1 PLN RYR2 SCN5A
2
Cardiac conduction 66
Show member pathways
 12.29 CALM1 KCNQ1 MYBPC3 PLN RYR2 SCN5A
3
Ion channel transport 66
Show member pathways
 12.23 CALM1 PLN RYR2 TRDN
4
Myometrial Relaxation and Contraction Pathways 1
Show member pathways
 12.2 CALM1 CASQ2 PLN RYR2
5
Dilated cardiomyopathy (DCM) 37
Show member pathways
 11.79 ACE MYBPC3 PLN RYR2 TNNT2
6
Ca, cAMP and Lipid Signaling 4
11.73 ALB CALM1 PLN S100B
7
Phase 0 - rapid depolarisation 66
Show member pathways
 11.42 CALM1 KCNQ1 SCN5A
8
Antiarrhythmic Pathway, Pharmacodynamics 61
10.85 CASQ2 DSP KCNQ1 PLN RYR2 SCN5A
Sources

GO Terms for Cardiac Arrest

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Cellular components related to Cardiac Arrest according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.67 CASQ2 MYBPC3 RYR2 SCN5A
2 sarcoplasmic reticulum GO:0016529 9.56 CASQ2 PLN RYR2 TRDN
3 calcium channel complex GO:0034704 9.5 CALM1 CASQ2 RYR2
4 striated muscle thin filament GO:0005865 9.48 MYBPC3 TNNT2
5 junctional membrane complex GO:0030314 9.46 CASQ2 TRDN
6 sarcomere GO:0030017 9.46 CALM1 MYBPC3 RYR2 TNNT2
7 cardiac myofibril GO:0097512 9.43 MYBPC3 TNNT2
8 sarcoplasmic reticulum lumen GO:0033018 9.4 CASQ2 TRDN
9 junctional sarcoplasmic reticulum membrane