MCID: CRD119
MIFTS: 71

Cardiac Arrest

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Cardiac Arrest

MalaCards integrated aliases for Cardiac Arrest:

Name: Cardiac Arrest 12 75 29 55 6 43 15 17 72 33
Cardiopulmonary Arrest 12 55 72
Circulatory Arrest 12 15 72
Heart Arrest 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0060319
ICD9CM 35 427.5
MeSH 44 D006323
SNOMED-CT 68 30298009
ICD10 33 I46 I46.0 I46.9
UMLS 72 C0018790 C0444720 C0600228

Summaries for Cardiac Arrest

MedlinePlus : 43 The heart has an internal electrical system that controls the rhythm of the heartbeat. Problems can cause abnormal heart rhythms, called arrhythmias. There are many types of arrhythmia. During an arrhythmia, the heart can beat too fast, too slow, or it can stop beating. Sudden cardiac arrest (SCA) occurs when the heart develops an arrhythmia that causes it to stop beating. This is different than a heart attack, where the heart usually continues to beat but blood flow to the heart is blocked. There are many possible causes of SCA. They include coronary heart disease, physical stress, and some inherited disorders. Sometimes there is no known cause for the SCA. Without medical attention, the person will die within a few minutes. People are less likely to die if they have early defibrillation. Defibrillation sends an electric shock to restore the heart rhythm to normal. You should give cardiopulmonary resuscitation (CPR) to a person having SCA until defibrillation can be done. If you have had an SCA, an implantable cardiac defibrillator (ICD) reduces the chance of dying from a second SCA. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Cardiac Arrest, also known as cardiopulmonary arrest, is related to ventricular fibrillation, paroxysmal familial, 1 and arrhythmogenic right ventricular cardiomyopathy, and has symptoms including angina pectoris, edema and chest pain. An important gene associated with Cardiac Arrest is PLN (Phospholamban), and among its related pathways/superpathways are Aldosterone synthesis and secretion and DREAM Repression and Dynorphin Expression. The drugs Clonazepam and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are behavior/neurological and cardiovascular system

Disease Ontology : 12 A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all.

Wikipedia : 75 Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to effectively... more...

Related Diseases for Cardiac Arrest

Diseases in the Cardiac Arrest family:

Post-Cardiac Arrest Syndrome

Diseases related to Cardiac Arrest via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 840)
# Related Disease Score Top Affiliating Genes
1 ventricular fibrillation, paroxysmal familial, 1 33.2 TNNT2 SCN5A RYR2 KCNQ1 DSP
2 arrhythmogenic right ventricular cardiomyopathy 33.1 SCN5A RYR2 PLN DSP
3 progressive familial heart block 32.7 TNNT2 SCN5A DSP
4 cardiac conduction defect 32.6 SCN5A RYR2 PLN MYBPC3 KCNQ1 DSP
5 long qt syndrome 32.5 SCN5A RYR2 MYBPC3 KCNQ1 CALM3 CALM1
6 catecholaminergic polymorphic ventricular tachycardia 32.4 TRDN SCN5A RYR2 MYBPC3 DSP CASQ2
7 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 32.3 TRDN SCN5A RYR2 KCNQ1 DSP CASQ2
8 long qt syndrome 1 32.3 TRDN SCN5A RYR2 KCNQ1 DSP CASQ2
9 myocardial infarction 32.2 TNNT2 S100B CKB ALB ACE
10 cardiac arrhythmia 31.4 SCN5A RYR2 KCNQ1
11 head injury 31.2 S100B ENO2
12 atrial standstill 1 30.9 TNNT2 SLC25A20 SCN5A PLN MYBPC3 DSP
13 hypertrophic cardiomyopathy 30.8 TNNT2 SCN5A RYR2 PLN MYBPC3 DSP
14 paroxysmal ventricular fibrillation 30.7 SCN5A DPP6
15 long qt syndrome 15 30.6 CALM3 CALM1
16 long qt syndrome 2 30.5 SCN5A RYR2 KCNQ1
17 long qt syndrome 13 30.5 SCN5A KCNQ1
18 atrial fibrillation 30.5 SCN5A RYR2 MYBPC3 KCNQ1 ACE
19 neonatal hypoxic and ischemic brain injury 30.4 ENO2 CKB
20 bacterial meningitis 30.1 S100B CKB ALB
21 middle cerebral artery infarction 30.0 S100B ENO2
22 left ventricular noncompaction 29.8 TNNT2 SCN5A RYR2 MYBPC3 KCNQ1 DSP
23 heart disease 29.8 TNNT2 SCN5A S100B RYR2 MYBPC3 KCNQ1
24 dilated cardiomyopathy 29.6 TRDN TNNT2 SCN5A RYR2 PLN MYBPC3
25 post-cardiac arrest syndrome 12.8
26 wolff-parkinson-white syndrome 11.6
27 jervell and lange-nielsen syndrome 1 11.6
28 ventricular tachycardia, catecholaminergic polymorphic, 3 11.6
29 anoxia 11.5
30 brugada syndrome 11.5
31 hypokalemia 11.5
32 myocarditis 11.5
33 pulmonary edema 11.5
34 cerebral hypoxia 11.5
35 hypoxia 11.5
36 orthostatic intolerance 11.5
37 coronary artery dissection, spontaneous 11.5
38 sick sinus syndrome 11.5
39 eclampsia 11.5
40 timothy syndrome 11.5
41 short qt syndrome 11.5
42 sudden cardiac failure, infantile 11.5
43 sudden cardiac failure, alcohol-induced 11.5
44 cyanide poisoning 11.5
45 cardiomyopathy, infantile histiocytoid 11.4
46 congenital disorder of glycosylation, type it 11.3
47 glycogen storage disease type 0 11.3
48 carnitine deficiency, systemic primary 11.1
49 cardiac arrhythmia, ankyrin-b-related 11.1
50 aromatic l-amino acid decarboxylase deficiency 11.1

Comorbidity relations with Cardiac Arrest via Phenotypic Disease Network (PDN): (show all 30)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Aortic Aneurysm Aortic Valve Disease 1
Bronchitis Cardiogenic Shock
Decubitus Ulcer Deficiency Anemia
Disseminated Intravascular Coagulation Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Intermediate Coronary Syndrome
Kidney Disease Mitral Valve Disease
Ocular Motor Apraxia Peripheral Vascular Disease
Progressive Familial Heart Block, Type Ia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Cardiac Arrest:



Diseases related to Cardiac Arrest

Symptoms & Phenotypes for Cardiac Arrest

UMLS symptoms related to Cardiac Arrest:


angina pectoris, edema, chest pain

MGI Mouse Phenotypes related to Cardiac Arrest:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 ACE CKB CYCS ENO2 KCNQ1 MYBPC3
2 cardiovascular system MP:0005385 9.85 ACE CASQ2 CYCS DSP KCNQ1 MYBPC3
3 growth/size/body region MP:0005378 9.7 ACE CASQ2 CKB CYCS DSP ENO2
4 muscle MP:0005369 9.28 ALB CASQ2 DSP KCNQ1 MYBPC3 RYR2

Drugs & Therapeutics for Cardiac Arrest

Drugs for Cardiac Arrest (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 443)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
2
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
4
Eplerenone Approved Phase 4 107724-20-9 150310 443872
5
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
6
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
7
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
8
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
9
Quinapril Approved, Investigational Phase 4 85441-61-8 54892
10
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
11
Parecoxib Approved Phase 4 198470-84-7
12
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
13
Thrombin Approved, Investigational Phase 4
14
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
15
Etomidate Approved Phase 4 33125-97-2 36339 667484
16
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
17
Ticagrelor Approved Phase 4 274693-27-5 9871419
18
Cangrelor Approved Phase 4 163706-06-7 9854012
19
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
20
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
21
Sodium citrate Approved, Investigational Phase 4 68-04-2
22
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
23
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
24
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
25 GABA Agents Phase 4
26 GABA Modulators Phase 4
27 Antimanic Agents Phase 4
28 Adrenergic alpha-2 Receptor Agonists Phase 4
29 HIV Protease Inhibitors Phase 4
30
protease inhibitors Phase 4
31 Calamus Phase 4
32 Analgesics, Non-Narcotic Phase 4
33 Cyclooxygenase Inhibitors Phase 4
34 Anti-Inflammatory Agents, Non-Steroidal Phase 4
35 Amoxicillin-Potassium Clavulanate Combination Phase 4
36 Hematinics Phase 4
37 Epoetin alfa Phase 4 113427-24-0
38 Antipyretics Phase 4
39 Sympatholytics Phase 4
40 Omega 3 Fatty Acid Phase 4
41 Sodium-Glucose Transporter 2 Inhibitors Phase 4
42 Antigen-Antibody Complex Phase 4
43 Cyclooxygenase 2 Inhibitors Phase 4
44 Ketorolac Tromethamine Phase 4
45 Parenteral Nutrition Solutions Phase 4
46 Fat Emulsions, Intravenous Phase 4
47 Prasugrel hydrochloride Phase 4 389574-19-0
48 Pharmaceutical Solutions Phase 4
49 Oxytocics Phase 4
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 1121)
# Name Status NCT ID Phase Drugs
1 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
2 Hyperinvasive Approach to out-of Hospital Cardiac Arrest Using Mechanical Chest Compression Device, Prehospital Intraarrest Cooling, Extracorporeal Life Support and Early Invasive Assessment Compared to Standard of Care. A Randomized Parallel Groups Comparative Study. "Prague OHCA Study" Unknown status NCT01511666 Phase 4
3 Immediate Unselected Coronary Angiography Versus Delayed Triage in Survivors of Out-of-hospital Cardiac Arrest Without ST-segment Elevation Unknown status NCT02750462 Phase 4
4 Combining Propofol With Therapeutic Hypothermia for Improving Survival and Neurological Prognoses in Patients Resuscitated From Cardiac Arrest Unknown status NCT02367755 Phase 4 Propofol;Lorazepam
5 Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial Unknown status NCT01377337 Phase 4 sodium bicarbonate
6 Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts Unknown status NCT02341833 Phase 4 Sevoflurane
7 Comparison of Enteral Versus Intravenous Potassium Supplementation in Hypokalemia in Post Cardiac Surgery Pediatric Cardiac Intensive Care Patients - Prospective Open Label Randomized Control Trial Unknown status NCT02015962 Phase 4 Intravenous potassium chloride;Oral potassium chloride
8 A Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Intra-articular Catheter (IAC) Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
9 Evaluation of the Effects and Plasma Concentration of the Potent Platelet Inhibitor Ticagrelor, After Crushed and Non-crushed Intake, After Semi-urgent Coronary Bypass and in Patients After Cardiac Arrest. Unknown status NCT02341729 Phase 4 ticagrelor
10 Comparing Heated Humidified High-flow Nasal Cannula Therapy and Nasal Continuous Positive Airway Pressure (nCPAP) Ventilation Methods for the Prevention of Extubation Failure in Preterm Infants Less Than 32 Weeks' Gestational Age: Randomized Clinical Trial Unknown status NCT02887846 Phase 4
11 A Double-Blinded Randomized Controlled Trial Comparing the Adductor Canal Catheter (ACC) and Local Infiltration of Analgesia (LIA) Following Primary Total Knee Arthroplasty Unknown status NCT02603900 Phase 4 ropivacaine;bupivacaine
12 A Randomised, Double-Blinded, Placebo-Controlled Trial Using Cardiovascular Magnetic Resonance (CMR) Scanning to Assess Remodelling and Regression of Fibrosis in Cardiomyopathy With Eplerenone Unknown status NCT00401856 Phase 4 Eplerenone;Placebo
13 Safety and Efficacy of Intranasal Dexmedetomidine as a Sedative in Pediatric Dentistry: a Randomized, Double-blind Clinical Study Unknown status NCT02985697 Phase 4 Dexmedetomidine;Midazolam Hydrochloride;Nitrous Oxide
14 Pilot Randomized Clinical Trial Comparing the Efficacy of Two Different Hypothermia Temperatures for Treatment of Comatose Patients Recovered From an Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
15 Clinical Interest of Endovascular Cooling in the Management of Cardiac Arrest: Impact on Mortality in a Randomized Medico-economical Trial (the ICEREA Study) Completed NCT00392639 Phase 4
16 Comparison of Antiplatelet Therapy With Clopidogrel and Ticagrelor in Patients After Cardiac Arrest Treated With Therapeutic Hypothermia Completed NCT02224274 Phase 4 Clopidogrel;Ticagrelor
17 Prophylactic Versus Clinically-driven Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest Completed NCT02899507 Phase 4 Amoxicillin-Clavulanic acid
18 Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER) Completed NCT00101881 Phase 4
19 Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-Hospital Cardiac Arrests Completed NCT00127907 Phase 4 epinephrine (1 mg/1 mL);arginine-vasopressin (40 UI/2 mL)
20 Clinical and Neurological Outcome With Two Different Cooling Methods (Invasive and Non-invasive) After Sudden Cardiac Arrest Completed NCT00843297 Phase 4
21 Clinical Evaluation of Intraosseous and Intravenous Access for Cardiac Arrest Treatment in Emergency Ambulances In Singapore Completed NCT02088736 Phase 4
22 Interest for a Relative of Seeing Himself Proposing to Witness Resuscitation of a Family Member Victim of a Cardiac Arrest Completed NCT01009606 Phase 4
23 Prevention of Acute Kidney Injury by Erythropoietin in Patients Undergoing Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4 recombinant human erythropoietin;saline
24 A Phased Prospective Clinical Study Comparing Controlled Therapeutic Hypothermia Post Resuscitation After Cardiac Arrest Using External and Internal Cooling to Standard Intensive Care Unit Therapy Completed NCT00827957 Phase 4
25 Trial Of Continuous Compressions Versus Standard CPR In Patients With Out-Of-Hospital Cardiac Arrest Completed NCT01372748 Phase 4
26 Out-of-Hospital Intubation in Emergency Conditions With Either Metal Single Use or Reusable Laryngoscope Blades : Impact on Intubation Difficulties Completed NCT00644722 Phase 4
27 Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary in Patients After Survived Cardiac Arrest? A Prospective Randomised Multi-centre Trial. Completed NCT00180362 Phase 4
28 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
29 Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial Completed NCT00667043 Phase 4 remifentanil and propofol;fentanyl and midazolam
30 Clinical Outcomes and Long Term Effects of Sodium-glucose Co-transporter 2 Inhibitors in Diabetes Mellitus and Failing Heart Patients With Implantable Cardioverter Defibrillator Undergoing Trans-catheter Ablation for Ventricular Arrhythmias. Completed NCT03977116 Phase 4 SLGT2;Placebo
31 The Ischemia Management With Accupril Post Bypass Graft Via Inhibition of the coNverting Enzyme (IMAGINE) Trial Completed NCT00269243 Phase 4 Quinapril
32 Comparison of Topical Analgesic With Saline Rinses in Post Extraction Healing Among Hypertensive and Non-hypertensive Subjects Completed NCT02921165 Phase 4 analgesic mouth rinses (dissolved Aspirin);Normal saline rinses.
33 Effects of OctaplasLG® on Endothelial Integrity in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Single-blinded Investigator-initiated Pilot Trial Completed NCT02253082 Phase 4 OctaplasLG®
34 Modulation of Remifentanil-induced Analgesia and Postinfusion Hyperalgesia by Parecoxib or Ketorolac in Humans Completed NCT00785863 Phase 4 Remifentanil;Ketorolac and remifentanil;Parecoxib and remifentanil
35 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement in Japan Completed NCT01221649 Phase 4
36 Clopidogrel Or Metoprolol in Myocardial Infarction Trial Completed NCT00222573 Phase 4 clopidogrel and metoprolol
37 Clinical Trial: Evaluation of 2 Different Protocols of Blood Derivates Transfusion in Acute Trauma Patients in a Brazilian Tertiary Hospital Completed NCT02416817 Phase 4
38 Monitoring of Fluid Status in Heart Failure Patients by Intrathoracic Impedance Measurement Completed NCT00711360 Phase 4
39 Effects of Treatment With Omacor for 6 Weeks on Preprandial and Postprandial Endothelial Function Following a High Fat Meal in Patients With Type 2 Diabetes Mellitus Completed NCT00328536 Phase 4 Omacor
40 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation: The PrePARE Trial Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
41 Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
42 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
43 An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol. Completed NCT02924454 Phase 4 metoprolol;intravenous lipid emulsion;Sodium chloride 0.9% solution - lipid emulsion dummy;Sodium chloride 0.9% solution - metoprolol dummy
44 Prophylactic Ephedrine to Reduce Fetal Bradycardia After Combined Spinal Epidural Labor Analgesia: a Randomized Double Blind Placebo-controlled Study Completed NCT02062801 Phase 4 Ephedrine;Placebo
45 Pharmacokinetic/Pharmacodynamic Effects of add-on Antiplatelet Therapy With Parenteral Cangrelor as Compared to Standard Dual Antiplatelet Treatment in Patients With ST-elevation Myocardial Infarction Complicated by Out-of-hospital Cardiac Arrest and Treated With Targeted Temperature Management Recruiting NCT03273075 Phase 4 Cangrelor;Placebo;Prasugrel;Ticagrelor
46 Comparison of the Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest: Multi-center, Double Blind, Randomized, Placebo-controlled Study Recruiting NCT03317197 Phase 4 Control Group;Experimental Group 1;Experimental Group 2;Experimental Group 3
47 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Recruiting NCT02643381 Phase 4 Etomidate;Ketamine
48 Preventing Cardiovascular Collapse With Administration of Fluid Resuscitation During Induction and Intubation (PREPARE II Trial) Recruiting NCT03787732 Phase 4 Fluid Bolus
49 The Effects of Hyperoxia on Organ Dysfunction and Outcome in Critically Ill Patients With SIRS Recruiting NCT02321072 Phase 4 Oxygen
50 Continued Versus Discontinued Oxytocin Stimulation of Labour in a Double-blind Randomised Controlled Trial Recruiting NCT02553226 Phase 4 Oxytocin;Placebo

Search NIH Clinical Center for Cardiac Arrest

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Atropine
Atropine Sulfate
Calcium Chloride
Calcium gluceptate
Calcium Gluconate
CALCIUM GLUCONATE PWDR
Epinephrine
epinephrine bitartrate
epinephrine hydrochloride
epinephryl borate
Isoprenaline
Methylatropine nitrate
Racepinephrine Hydrochloride
Sodium Bicarbonate
SODIUM BICARBONATE PWDR

Cochrane evidence based reviews: heart arrest

Genetic Tests for Cardiac Arrest

Genetic tests related to Cardiac Arrest:

# Genetic test Affiliating Genes
1 Cardiac Arrest 29

Anatomical Context for Cardiac Arrest

MalaCards organs/tissues related to Cardiac Arrest:

41
Heart, Brain, Lung, Liver, Kidney, Testes, Spinal Cord

Publications for Cardiac Arrest

Articles related to Cardiac Arrest:

(show top 50) (show all 35232)
# Title Authors PMID Year
1
A comparison of intravascular and surface cooling devices for targeted temperature management after out-of-hospital cardiac arrest: A nationwide observational study. 38 17
31348276 2019
2
Ventricular Arrhythmias. 17
31378332 2019
3
Sudden Cardiac Death: Who Is at Risk? 17
31378334 2019
4
Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest. 9 38
19307814 2009
5
Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia. 9 38
19467754 2009
6
Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. 9 38
18954930 2009
7
Serum neuron specific enolase to predict neurological outcome after cardiopulmonary resuscitation: a critically appraised topic. 9 38
19131859 2009
8
[Role of neuron specific enolase and S100 protein in evaluation of brain damage in patients resuscitated from cardiac arrest]. 9 38
18093437 2007
9
Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation. 9 38
17482335 2007
10
Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100. 9 38
17502328 2007
11
2006 Curt P. Richter award winner: Social influences on stress responses and health. 9 38
17590276 2007
12
Carnitine-acylcarnitine translocase deficiency in three neonates presenting with rapid deterioration and cardiac arrest. 9 38
17277394 2007
13
Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrest. 9 38
16920803 2007
14
Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope. 9 38
17199967 2006
15
Allelic variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease. 9 38
16731473 2006
16
Disorders of carnitine transport and the carnitine cycle. 9 38
16602102 2006
17
Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia. 9 38
16337513 2006
18
Serum neuron-specific enolase as early predictor of outcome after in-hospital cardiac arrest: a cohort study. 9 38
16978415 2006
19
Changes of cytoskeletal proteins in ischaemic brain under cardiac arrest and reperfusion conditions. 9 38
16823696 2006
20
Ability of neuron-specific enolase to predict survival to hospital discharge after successful cardiopulmonary resuscitation. 9 38
17175624 2006
21
Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale. 9 38
15797275 2005
22
Pulmonary haemorrhage and cardiac dysfunction in a neonate with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. 9 38
15858970 2005
23
Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. 9 38
15541008 2004
24
[Stem cell mobilization after coronary artery bypass grafting]. 9 38
15253141 2004
25
Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia. 9 38
14631087 2003
26
Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia. 9 38
12605885 2003
27
Sialic acid or troponin T to detect perioperative myocardial damage in patients undergoing elective coronary artery bypass grafting. 9 38
12419933 2002
28
Natural history of Brugada syndrome: insights for risk stratification and management. 9 38
11901046 2002
29
Variable expression of long QT syndrome among gene carriers from families with five different HERG mutations. 9 38
11844290 2002
30
Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. 9 38
11382525 2001
31
Apical hypertrophic cardiomyopathy due to a de novo mutation Arg719Trp of the beta-myosin heavy chain gene and cardiac arrest in childhood. A case report and family study. 9 38
10957787 2000
32
Time course of serum neuron-specific enolase. A predictor of neurological outcome in patients resuscitated from cardiac arrest. 9 38
10436107 1999
33
Monitoring of extracellular aspartate aminotransferase and troponin T by microdialysis during and after cardioplegic heart arrest. 9 38
10754346 1999
34
Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage. 9 38
9732976 1998
35
Serum neuron-specific enolase levels do not increase after electroconvulsive therapy. 9 38
9268247 1997
36
Creatine kinase-mb fraction and cardiac troponin T to diagnose acute myocardial infarction after cardiopulmonary resuscitation. 9 38
8890819 1996
37
Corticosteroid and immune responses to cardiac surgery. 9 38
8837293 1996
38
Creatine kinase and creatine kinase-MB release after nontraumatic cardiac arrest. 9 38
8610606 1996
39
[Hypoxic brain damage after prolonged cardiac arrest during anesthesia--changes in CT and serum NSE concentration]. 9 38
7933514 1994
40
Serum corticosteroid-binding globulin levels in children undergoing heart surgery. 9 38
8273117 1993
41
CSF and serum brain-specific creatine kinase isoenzyme (CK-BB), neuron-specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man. 9 38
8509798 1993
42
Determinants of elevated creatine kinase activity and creatine kinase MB-fraction following cardiopulmonary resuscitation. 9 38
1582302 1992
43
Evaluation of hypoxic brain injury with spinal fluid enzymes, lactate, and pyruvate. 9 38
1541099 1992
44
Changes of neuron-specific enolase concentration in plasma after cardiac arrest and resuscitation. 9 38
1958265 1991
45
MicroRNA expression in the hippocampal CA1 region under deep hypothermic circulatory arrest. 38
31290459 2019
46
The incidence of acute kidney injury following cardiac arrest and cardiopulmonary resuscitation in a rat model. 38
31014141 2019
47
Editorial commentary: The challenge of sudden cardiac arrest in patients with structural heart disease: Still a long way to go. 38
30553704 2019
48
Mesenchymal stem cells derived from induced pluripotent stem cells play a key role in immunomodulation during cardiopulmonary resuscitation. 38
31201814 2019
49
App-based learning as an alternative for instructors in teaching basic life support to school children: a randomized control trial. 38
30105946 2019
50
Predictors of Acute Kidney Injury Following Aortic Arch Surgery. 38
31063910 2019

Variations for Cardiac Arrest

ClinVar genetic disease variations for Cardiac Arrest:

6 (show all 35)
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 PLN NM_002667.5(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic/Likely pathogenic rs111033560 6:118880200-118880200 6:118559037-118559037
2 DSP NM_004415.4(DSP): c.2821C> T (p.Arg941Ter) single nucleotide variant Pathogenic/Likely pathogenic rs730880082 6:7577219-7577219 6:7576986-7576986
3 TTN NM_001267550.2(TTN): c.29230C> T (p.Arg9744Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs375266859 2:179571371-179571371 2:178706644-178706644
4 CACNB2 NM_201590.3(CACNB2): c.1480G> A (p.Gly494Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs730880059 10:18828312-18828312 10:18539383-18539383
5 DSG2 NM_001943.5(DSG2): c.437G> T (p.Arg146Leu) single nucleotide variant Conflicting interpretations of pathogenicity rs113451409 18:29101120-29101120 18:31521157-31521157
6 SCN5A NM_000335.4(SCN5A): c.559A> G (p.Thr187Ala) single nucleotide variant Conflicting interpretations of pathogenicity rs869025517 3:38662386-38662386 3:38620895-38620895
7 DSG2 NM_001943.5(DSG2): c.1063G> A (p.Ala355Thr) single nucleotide variant Conflicting interpretations of pathogenicity rs201046640 18:29110998-29110998 18:31531035-31531035
8 RYR2 NM_001035.3(RYR2): c.378T> A (p.Ser126Arg) single nucleotide variant Uncertain significance rs869025507 1:237532902-237532902 1:237369602-237369602
9 SCN5A NM_000335.4(SCN5A): c.5072T> C (p.Phe1691Ser) single nucleotide variant Uncertain significance rs869025521 3:38592788-38592788 3:38551297-38551297
10 SLMAP NM_007159.4(SLMAP): c.1918+1G> A single nucleotide variant Uncertain significance rs869025527 3:57898429-57898429 3:57912702-57912702
11 ANK2 NM_001148.6(ANK2): c.5509G> A (p.Ala1837Thr) single nucleotide variant Uncertain significance rs199527708 4:114275283-114275283 4:113354127-113354127
12 ANK2 NM_001148.6(ANK2): c.7458C> G (p.His2486Gln) single nucleotide variant Uncertain significance rs776972443 4:114277232-114277232 4:113356076-113356076
13 ANK2 NM_001148.6(ANK2): c.7577C> T (p.Ser2526Leu) single nucleotide variant Uncertain significance rs762909298 4:114277351-114277351 4:113356195-113356195
14 DSP NM_004415.4(DSP): c.2047G> A (p.Glu683Lys) single nucleotide variant Uncertain significance rs775181391 6:7572218-7572218 6:7571985-7571985
15 DSP NM_004415.4(DSP): c.7249G> T (p.Asp2417Tyr) single nucleotide variant Uncertain significance rs760501352 6:7584744-7584744 6:7584511-7584511
16 DPP6 NM_001039350.3(DPP6): c.847G> A (p.Ala283Thr) single nucleotide variant Uncertain significance rs770646362 7:154564555-154564555 7:154772845-154772845
17 AKAP9 NM_005751.4(AKAP9): c.1067A> T (p.Asp356Val) single nucleotide variant Uncertain significance rs533277424 7:91630298-91630298 7:92000984-92000984
18 AKAP9 NM_005751.4(AKAP9): c.11276C> T (p.Pro3759Leu) single nucleotide variant Uncertain significance rs869025356 7:91732086-91732086 7:92102772-92102772
19 CACNB2 NM_201590.3(CACNB2): c.1432T> G (p.Ser478Ala) single nucleotide variant Uncertain significance rs869025371 10:18828264-18828264 10:18539335-18539335
20 KCNJ8 NM_004982.4(KCNJ8): c.83G> C (p.Arg28Pro) single nucleotide variant Uncertain significance rs768851540 12:21926468-21926468 12:21773534-21773534
21 HCN4 NM_005477.3(HCN4): c.2197G> A (p.Val733Ile) single nucleotide variant Uncertain significance rs376631391 15:73616237-73616237 15:73323896-73323896
22 MYOM1 NM_003803.3(MYOM1): c.3708C> A (p.Ser1236Arg) single nucleotide variant Uncertain significance rs869025489 18:3100176-3100176 18:3100178-3100178
23 DSG2 NM_001943.5(DSG2): c.2188A> G (p.Thr730Ala) single nucleotide variant Uncertain significance rs780650226 18:29122669-29122669 18:31542706-31542706
24 TRPM4 NM_017636.4(TRPM4): c.1069C> T (p.Arg357Trp) single nucleotide variant Uncertain significance rs764690335 19:49675284-49675284 19:49172027-49172027
25 DSP NM_004415.4(DSP): c.2260G> A (p.Glu754Lys) single nucleotide variant Uncertain significance rs730880080 6:7574448-7574448 6:7574215-7574215
26 RYR2 NM_001035.3(RYR2): c.13759A> C (p.Ile4587Leu) single nucleotide variant Uncertain significance rs730880198 1:237955600-237955600 1:237792300-237792300
27 AKAP9 NM_005751.4(AKAP9): c.11378C> G (p.Ser3793Cys) single nucleotide variant Uncertain significance rs730880044 7:91735039-91735039 7:92105725-92105725
28 MYH6 NM_002471.3(MYH6): c.4713G> T (p.Lys1571Asn) single nucleotide variant Uncertain significance rs730880151 14:23855770-23855770 14:23386561-23386561
29 CACNB2 NM_201590.3(CACNB2): c.1044+3A> T single nucleotide variant Uncertain significance rs200174877 10:18823159-18823159 10:18534230-18534230
30 AKAP9 NM_005751.4(AKAP9): c.1099G> A (p.Val367Met) single nucleotide variant Likely benign rs138161478 7:91630330-91630330 7:92001016-92001016
31 ANK2 NM_001148.6(ANK2): c.6206G> A (p.Arg2069His) single nucleotide variant Likely benign rs149645600 4:114275980-114275980 4:113354824-113354824
32 MYBPC3 NM_000256.3(MYBPC3): c.3392T> C (p.Ile1131Thr) single nucleotide variant Likely benign rs370890951 11:47354463-47354463 11:47332912-47332912
33 DSC2 NM_004949.5(DSC2): c.1073C> T (p.Thr358Ile) single nucleotide variant Benign/Likely benign rs139399951 18:28662896-28662896 18:31082930-31082930
34 SCN5A NM_000335.4(SCN5A): c.1715C> A (p.Ala572Asp) single nucleotide variant Benign/Likely benign rs36210423 3:38645378-38645378 3:38603887-38603887
35 CACNA2D1 NM_000722.4(CACNA2D1): c.2264G> C (p.Ser755Thr) single nucleotide variant Benign/Likely benign rs151327713 7:81599241-81599241 7:81969925-81969925

Expression for Cardiac Arrest

Search GEO for disease gene expression data for Cardiac Arrest.

Pathways for Cardiac Arrest

Pathways related to Cardiac Arrest according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 TNNT2 SCN5A RYR2 PLN KCNQ1 CALM3
2
Show member pathways
12.43 RYR2 CYCS CALM3 CALM1
3
Show member pathways
12.35 TRDN RYR2 PLN CALM3 CALM1
4
Show member pathways
12.34 TRDN TNNT2 SCN5A RYR2 PLN MYBPC3
5
Show member pathways
12.32 RYR2 PLN CASQ2 CALM3 CALM1
6 12.13 RYR2 PLN CALM3 CALM1
7
Show member pathways
12.07 RYR2 PLN CALM3 CALM1
8
Show member pathways
11.92 TNNT2 RYR2 PLN MYBPC3 ACE
9 11.77 S100B PLN CALM1 ALB
10 11.53 CALM3 CALM1 ACE
11
Show member pathways
11.5 SCN5A KCNQ1 CALM3 CALM1
12 11.12 CYCS CALM3 CALM1
13 10.85 SCN5A RYR2 PLN KCNQ1 DSP CASQ2
14 10.64 CALM3 CALM1

GO Terms for Cardiac Arrest

Cellular components related to Cardiac Arrest according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.71 SCN5A RYR2 MYBPC3 CASQ2
2 voltage-gated potassium channel complex GO:0008076 9.69 KCNQ1 DPP6 CALM3
3 sarcoplasmic reticulum GO:0016529 9.67 TRDN RYR2 PLN CASQ2
4 catalytic complex GO:1902494 9.49 CALM3 CALM1
5 sarcoplasmic reticulum lumen GO:0033018 9.48 TRDN CASQ2
6 junctional membrane complex GO:0030314 9.46 TRDN CASQ2
7 sarcoplasmic reticulum membrane GO:0033017 9.46 TRDN RYR2 PLN CASQ2
8 cardiac myofibril GO:0097512 9.43 TNNT2 MYBPC3
9 junctional sarcoplasmic reticulum membrane GO:0014701 9.43 TRDN RYR2 CASQ2
10 myelin sheath GO:0043209 9.32 CALM3 CALM1
11 calcium channel complex GO:0034704 9.26 RYR2 CASQ2 CALM3 CALM1
12 sarcomere GO:0030017 9.02 TNNT2 RYR2 MYBPC3 CALM3 CALM1

Biological processes related to Cardiac Arrest according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.86 TRDN RYR2 PLN
2 calcium-mediated signaling GO:0019722 9.84 RYR2 CALM3 CALM1
3 muscle contraction GO:0006936 9.84 TRDN TNNT2 MYBPC3 CALM1
4 response to calcium ion GO:0051592 9.81 TNNT2 CALM3 CALM1
5 substantia nigra development GO:0021762 9.77 CKB CALM3 CALM1
6 sarcomere organization GO:0045214 9.76 TNNT2 MYBPC3 CASQ2
7 regulation of cardiac conduction GO:1903779 9.75 TRDN RYR2 CASQ2
8 regulation of heart rate by cardiac conduction GO:0086091 9.74 SCN5A KCNQ1 DSP
9 regulation of heart contraction GO:0008016 9.73 TNNT2 PLN KCNQ1
10 ion transmembrane transport GO:0034220 9.73 TRDN SCN5A RYR2 CASQ2
11 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.69 CALM3 CALM1
12 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.68 CALM3 CALM1
13 heart contraction GO:0060047 9.68 TRDN ACE
14 regulation of cardiac muscle cell contraction GO:0086004 9.68 SCN5A PLN
15 negative regulation of ATPase activity GO:0032780 9.67 TNNT2 PLN
16 cellular response to epinephrine stimulus GO:0071872 9.67 RYR2 KCNQ1
17 regulation of cardiac muscle contraction GO:0055117 9.67 RYR2 CALM3 CALM1
18 detection of calcium ion GO:0005513 9.67 RYR2 CASQ2 CALM3 CALM1
19 regulation of synaptic vesicle endocytosis GO:1900242 9.66 CALM3 CALM1
20 regulation of membrane repolarization GO:0060306 9.66 KCNQ1 CASQ2
21 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.65 RYR2 DSP
22 establishment of protein localization to membrane GO:0090150 9.65 CALM3 CALM1
23 cellular response to caffeine GO:0071313 9.65 RYR2 CASQ2
24 ventricular cardiac muscle cell action potential GO:0086005 9.65 SCN5A RYR2 KCNQ1
25 regulation of heart rate GO:0002027 9.65 SCN5A RYR2 CASQ2 CALM3 CALM1
26 atrial cardiac muscle cell action potential GO:0086014 9.64 SCN5A KCNQ1
27 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.64 CALM3 CALM1
28 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.63 TRDN RYR2
29 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.63 PLN CALM3 CALM1
30 regulation of high voltage-gated calcium channel activity GO:1901841 9.62 CALM3 CALM1
31 regulation of cardiac muscle cell membrane potential GO:0086036 9.62 TRDN PLN
32 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.62 TRDN CASQ2 CALM3 CALM1
33 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.61 SCN5A KCNQ1
34 regulation of cell communication by electrical coupling GO:0010649 9.61 TRDN CASQ2
35 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.6 CALM3 CALM1
36 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.58 TRDN CALM3 CALM1
37 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 9.55 CALM3 CALM1
38 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.55 TRDN PLN CASQ2 CALM3 CALM1
39 Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 9.52 RYR2 CASQ2
40 establishment of protein localization to mitochondrial membrane GO:0090151 9.51 CALM3 CALM1
41 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.35 RYR2 PLN CASQ2 CALM3 CALM1
42 cardiac muscle contraction GO:0060048 9.1 TNNT2 SCN5A RYR2 MYBPC3 KCNQ1 CASQ2

Molecular functions related to Cardiac Arrest according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.91 TNNT2 S100B RYR2 CASQ2 CALM3 CALM1
2 scaffold protein binding GO:0097110 9.63 SCN5A KCNQ1 DSP
3 dipeptidyl-peptidase activity GO:0008239 9.55 DPP6 ACE
4 protein kinase A catalytic subunit binding GO:0034236 9.54 RYR2 KCNQ1
5 adenylate cyclase binding GO:0008179 9.52 CALM3 CALM1
6 protein binding, bridging GO:0030674 9.51 TRDN TNNT2
7 protein phosphatase activator activity GO:0072542 9.49 CALM3 CALM1
8 nitric-oxide synthase regulator activity GO:0030235 9.48 CALM3 CALM1
9 nitric-oxide synthase binding GO:0050998 9.43 SCN5A CALM3 CALM1
10 adenylate cyclase activator activity GO:0010856 9.4 CALM3 CALM1
11 N-terminal myristoylation domain binding GO:0031997 9.37 CALM3 CALM1
12 titin binding GO:0031432 9.33 MYBPC3 CALM3 CALM1
13 type 3 metabotropic glutamate receptor binding GO:0031800 9.32 CALM3 CALM1
14 calcium-dependent protein binding GO:0048306 9.26 S100B CASQ2 CALM3 CALM1
15 ion channel binding GO:0044325 9.1 TRDN SCN5A RYR2 KCNQ1 CALM3 CALM1

Sources for Cardiac Arrest

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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