Cardiac Arrest

Categories: Blood diseases, Cardiovascular diseases, Respiratory diseases

Aliases & Classifications for Cardiac Arrest

MalaCards integrated aliases for Cardiac Arrest:

Name: Cardiac Arrest 12 74 29 54 6 42 15 17 71 32
Cardiopulmonary Arrest 12 54 71
Circulatory Arrest 12 15 71
Heart Arrest 44


External Ids:

Disease Ontology 12 DOID:0060319
ICD9CM 34 427.5
MeSH 44 D006323
SNOMED-CT 67 30298009
ICD10 32 I46 I46.0 I46.9
UMLS 71 C0018790 C0444720 C0600228

Summaries for Cardiac Arrest

MedlinePlus : 42 The heart has an internal electrical system that controls the rhythm of the heartbeat. Problems can cause abnormal heart rhythms, called arrhythmias. There are many types of arrhythmia. During an arrhythmia, the heart can beat too fast, too slow, or it can stop beating. Sudden cardiac arrest (SCA) occurs when the heart develops an arrhythmia that causes it to stop beating. This is different than a heart attack, where the heart usually continues to beat but blood flow to the heart is blocked. There are many possible causes of SCA. They include coronary heart disease, physical stress, and some inherited disorders. Sometimes there is no known cause for the SCA. Without medical attention, the person will die within a few minutes. People are less likely to die if they have early defibrillation. Defibrillation sends an electric shock to restore the heart rhythm to normal. You should give cardiopulmonary resuscitation (CPR) to a person having SCA until defibrillation can be done. If you have had an SCA, an implantable cardiac defibrillator (ICD) reduces the chance of dying from a second SCA. NIH: National Heart, Lung, and Blood Institute

MalaCards based summary : Cardiac Arrest, also known as cardiopulmonary arrest, is related to post-cardiac arrest syndrome and ventricular fibrillation, paroxysmal familial, 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Cardiac Arrest is DSP (Desmoplakin), and among its related pathways/superpathways are cGMP-PKG signaling pathway and Cardiac conduction. The drugs Valproic acid and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and liver, and related phenotypes are cardiovascular system and embryo

Disease Ontology : 12 A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all.

Wikipedia : 74 Cardiac arrest is a sudden loss of blood flow resulting from the failure of the heart to pump... more...

Related Diseases for Cardiac Arrest

Diseases in the Cardiac Arrest family:

Post-Cardiac Arrest Syndrome

Diseases related to Cardiac Arrest via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 888)
# Related Disease Score Top Affiliating Genes
1 post-cardiac arrest syndrome 33.1 S100B ENO2
2 ventricular fibrillation, paroxysmal familial, 1 32.7 TNNT2 SCN5A RYR2 KCNH2 DSP
3 ventricular tachycardia, catecholaminergic polymorphic, 3 32.4 RYR2 CASQ2
4 jervell and lange-nielsen syndrome 1 32.3 SCN5A KCNH2 CASQ2
5 ventricular tachycardia, catecholaminergic polymorphic, 2 32.1 TRDN RYR2 CASQ2
6 long qt syndrome 15 32.1 TRDN CALM1
7 wolff-parkinson-white syndrome 32.0 TNNT2 SCN5A MYH7 MYBPC3 CASQ2
8 short qt syndrome 32.0 SCN5A RYR2 KCNH2 CASQ2
9 cardiac arrhythmia, ankyrin-b-related 32.0 SCN5A RYR2 KCNH2
10 long qt syndrome 14 32.0 TRDN SCN5A KCNH2 CALM1
11 timothy syndrome 32.0 TRDN SCN5A RYR2 KCNH2 CASQ2
12 cardiac conduction defect 31.8 SCN5A RYR2 MYH7 MYBPC3 KCNH2 DSP
13 malignant hyperthermia 31.7 TRDN SCN5A RYR2 MYH7 KCNH2 CASQ2
14 arrhythmogenic right ventricular cardiomyopathy 31.7 SCN5A RYR2 PLN MYH7 KCNH2 DSP
15 syncope 31.6 TNNT2 SCN5A RYR2 KCNH2
16 long qt syndrome 31.6 TRDN SCN5A RYR2 MYH7 MYBPC3 KCNH2
17 myocardial infarction 31.6 TNNT2 SCN5A S100B MYH7 CYCS CKB
18 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 31.5 TRDN SCN5A RYR2 MYH7 KCNH2 DSP
19 progressive familial heart block 31.4 TNNT2 SCN5A RYR2 MYH7 MYBPC3 KCNH2
20 long qt syndrome 1 31.4 TRDN TNNT2 SCN5A RYR2 MYH7 MYBPC3
21 head injury 31.3 S100B ENO2
22 catecholaminergic polymorphic ventricular tachycardia 31.3 TRDN TNNT2 SCN5A RYR2 MYH7 MYBPC3
23 progressive familial heart block, type ia 31.3 SCN5A DSP
24 brugada syndrome 31.3 TRDN TNNT2 SCN5A RYR2 PLN MYH7
25 cardiac arrhythmia 31.2 SCN5A RYR2 KCNH2 DSP
26 traumatic brain injury 31.1 S100B ENO2
27 left bundle branch hemiblock 31.0 TNNT2 SCN5A RYR2 DSP ACE
28 right bundle branch block 31.0 SCN5A KCNH2 ACE
29 atrioventricular block 31.0 SCN5A RYR2 MYH7 KCNH2 ACE
30 congestive heart failure 30.9 TNNT2 SCN5A RYR2 PLN MYH7 ACE
31 familial long qt syndrome 30.9 SCN5A KCNH2 DSP CALM1
32 atrial standstill 1 30.8 TNNT2 SLC25A20 SCN5A RYR2 MYH7 MYBPC3
33 peripartum cardiomyopathy 30.7 SCN5A MYH7 ACE
34 lipoprotein quantitative trait locus 30.7 TNNT2 SCN5A RYR2 MYH7 MYBPC3 KCNH2
35 third-degree atrioventricular block 30.7 SCN5A KCNH2 ACE
36 atrial heart septal defect 30.6 TNNT2 SCN5A MYH7 ACE
37 sinoatrial node disease 30.5 SCN5A RYR2 KCNH2
38 atrial fibrillation 30.5 SCN5A RYR2 MYH7 MYBPC3 KCNH2 ACE
39 mitral valve insufficiency 30.5 TNNT2 MYH7 MYBPC3 CKB ACE
40 hypertrophic cardiomyopathy 30.4 TNNT2 SCN5A RYR2 PLN MYH7 MYBPC3
41 pericarditis 30.4 TNNT2 ENO2 ACE
42 aortic valve disease 2 30.4 TNNT2 MYH7 MYBPC3 ACE
43 horner's syndrome 30.4 RYR2 ENO2
44 long qt syndrome 13 30.3 SCN5A KCNH2
45 tetralogy of fallot 30.3 TNNT2 SCN5A RYR2 KCNH2 ENO2 ACE
46 asphyxia neonatorum 30.3 S100B ENO2
47 heart disease 30.3 TNNT2 SCN5A S100B RYR2 MYH7 MYBPC3
48 peripheral nervous system disease 30.2 S100B MIR122 ENO2 CYCS ACE
49 neonatal hypoxic and ischemic brain injury 30.2 ENO2 CKB
50 dilated cardiomyopathy 30.1 TRDN TNNT2 SCN5A RYR2 PLN MYH7

Comorbidity relations with Cardiac Arrest via Phenotypic Disease Network (PDN): (show all 30)

Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Myocardial Infarction
Aortic Aneurysm Aortic Valve Disease 1
Bronchitis Cardiogenic Shock
Decubitus Ulcer Deficiency Anemia
Disseminated Intravascular Coagulation Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Syndrome Intermediate Coronary Syndrome
Kidney Disease Mitral Valve Disease
Ocular Motor Apraxia Peripheral Vascular Disease
Progressive Familial Heart Block, Type Ia Protein-Energy Malnutrition
Pulmonary Hypertension, Primary, 1 Respiratory Failure
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to Cardiac Arrest:

Diseases related to Cardiac Arrest

Symptoms & Phenotypes for Cardiac Arrest

UMLS symptoms related to Cardiac Arrest:

angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Cardiac Arrest:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.9 ACE CASQ2 CYCS DSP KCNH2 MYBPC3
2 embryo MP:0005380 9.61 ACE CASQ2 CYCS DSP KCNH2 RYR2
3 muscle MP:0005369 9.28 CASQ2 DSP KCNH2 MYBPC3 MYH7 RYR2

Drugs & Therapeutics for Cardiac Arrest

Drugs for Cardiac Arrest (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 236)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Remifentanil Approved Phase 4 132875-61-7 60815
Zinc Approved, Investigational Phase 4 7440-66-6 32051
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
Clavulanate Approved, Vet_approved Phase 4 58001-44-8 5280980
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Meperidine Approved Phase 4 57-42-1 4058
Ticagrelor Approved Phase 4 274693-27-5 9871419
Cangrelor Approved Phase 4 163706-06-7 9854012
Sulfamethazine Approved, Investigational, Vet_approved Phase 4 57-68-1 5327
Etomidate Approved Phase 4 33125-97-2 36339 667484
Racepinephrine Approved Phase 4 329-65-7 838
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
21 Kava Approved, Investigational, Nutraceutical Phase 4 9000-38-8
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
23 Anticonvulsants Phase 4
24 GABA Modulators Phase 4
25 Methylprednisolone Acetate Phase 4
26 Liver Extracts Phase 4
27 Hemostatics Phase 4
28 Arginine Vasopressin Phase 4
29 Vasopressins Phase 4
30 Coagulants Phase 4
31 Anti-Infective Agents Phase 4
32 Dermatologic Agents Phase 4
33 Analgesics, Non-Narcotic Phase 4
34 Analgesics Phase 4
35 Narcotics Phase 4
36 Analgesics, Opioid Phase 4
37 Epoetin alfa Phase 4 113427-24-0
38 Keratolytic Agents Phase 4
39 Pyrithione zinc Phase 4
40 Antibiotics, Antitubercular Phase 4
41 Amoxicillin-Potassium Clavulanate Combination Phase 4
42 Anti-Bacterial Agents Phase 4
43 beta-Lactamase Inhibitors Phase 4
44 Hematinics Phase 4
45 Pharmaceutical Solutions Phase 4
46 Prasugrel hydrochloride Phase 4 389574-19-0
47 Purinergic P2Y Receptor Antagonists Phase 4
48 Cardioplegic Solutions Phase 4
49 Mineralocorticoid Receptor Antagonists Phase 4
50 Mineralocorticoids Phase 4

Interventional clinical trials:

(show top 50) (show all 727)
# Name Status NCT ID Phase Drugs
1 Does the Early Use of Sodium Bicarbonate Improve Results of Cardiopulmonary Resuscitation Following Out-of-Hospital Cardiac Arrest - a Prospective, Controlled Clinical Trial Unknown status NCT01377337 Phase 4 sodium bicarbonate
2 Hyperinvasive Approach to out-of Hospital Cardiac Arrest Using Mechanical Chest Compression Device, Prehospital Intraarrest Cooling, Extracorporeal Life Support and Early Invasive Assessment Compared to Standard of Care. A Randomized Parallel Groups Comparative Study. "Prague OHCA Study" Unknown status NCT01511666 Phase 4
3 Combining Propofol With Therapeutic Hypothermia for Improving Survival and Neurological Prognoses in Patients Resuscitated From Cardiac Arrest Unknown status NCT02367755 Phase 4 Propofol;Lorazepam
4 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
5 Comparison of the Effect of Vasopressin, Steroid, and Epinephrine Treatment in Patients With Out-of-hospital Cardiac Arrest: Multi-center, Double Blind, Randomized, Placebo-controlled Study Unknown status NCT03317197 Phase 4 Control Group;Experimental Group 1;Experimental Group 2;Experimental Group 3
6 Effects of Preconditioning With Sevoflurane During Organ Procurement From Brain Dead Donors: Impact on Early Function of Liver Allografts Unknown status NCT02341833 Phase 4 Sevoflurane
7 Evaluation of the Effects and Plasma Concentration of the Potent Platelet Inhibitor Ticagrelor, After Crushed and Non-crushed Intake, After Semi-urgent Coronary Bypass and in Patients After Cardiac Arrest. Unknown status NCT02341729 Phase 4 ticagrelor
8 Trial Of Continuous Compressions Versus Standard CPR In Patients With Out-Of-Hospital Cardiac Arrest Completed NCT01372748 Phase 4
9 Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial Completed NCT00667043 Phase 4 remifentanil and propofol;fentanyl and midazolam
10 Immediate Unselected Coronary Angiography Versus Delayed Triage in Survivors of Out-of-hospital Cardiac Arrest Without ST-segment Elevation Completed NCT02750462 Phase 4
11 Transthoracic Incremental Monophasic Versus Biphasic by Emergency Responders (TIMBER) Completed NCT00101881 Phase 4
12 Is Extensive Electrophysiological Testing Before, During and After ICD-Implantation Still Necessary in Patients After Survived Cardiac Arrest? A Prospective Randomised Multi-centre Trial. Completed NCT00180362 Phase 4
13 Comparison of Epinephrine Associated With Vasopressin vs Epinephrine Alone in the Treatment of Out-of-Hospital Cardiac Arrests Completed NCT00127907 Phase 4 epinephrine (1 mg/1 mL);arginine-vasopressin (40 UI/2 mL)
14 Clinical Evaluation of Intraosseous and Intravenous Access for Cardiac Arrest Treatment in Emergency Ambulances In Singapore Completed NCT02088736 Phase 4
15 Out-of-Hospital Intubation in Emergency Conditions With Either Metal Single Use or Reusable Laryngoscope Blades : Impact on Intubation Difficulties Completed NCT00644722 Phase 4
16 Comparison of Antiplatelet Therapy With Clopidogrel and Ticagrelor in Patients After Cardiac Arrest Treated With Therapeutic Hypothermia Completed NCT02224274 Phase 4 Clopidogrel;Ticagrelor
17 Prophylactic Versus Clinically-driven Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest Completed NCT02899507 Phase 4 Amoxicillin-Clavulanic acid
18 Interest for a Relative of Seeing Himself Proposing to Witness Resuscitation of a Family Member Victim of a Cardiac Arrest Completed NCT01009606 Phase 4
19 Clinical and Neurological Outcome With Two Different Cooling Methods (Invasive and Non-invasive) After Sudden Cardiac Arrest Completed NCT00843297 Phase 4
20 A Phased Prospective Clinical Study Comparing Controlled Therapeutic Hypothermia Post Resuscitation After Cardiac Arrest Using External and Internal Cooling to Standard Intensive Care Unit Therapy Completed NCT00827957 Phase 4
21 Pilot Randomized Clinical Trial Comparing the Efficacy of Two Different Hypothermia Temperatures for Treatment of Comatose Patients Recovered From an Out-of-hospital Cardiac Arrest Completed NCT01155622 Phase 4
22 Prevention of Acute Kidney Injury by Erythropoietin in Patients Undergoing Thoracic Aorta Surgery With Hypothermic Cardiac Arrest Completed NCT01369732 Phase 4 recombinant human erythropoietin;saline
23 Clinical Interest of Endovascular Cooling in the Management of Cardiac Arrest: Impact on Mortality in a Randomized Medico-economical Trial (the ICEREA Study) Completed NCT00392639 Phase 4
24 Effect of Intraoperative Dexmedetomidine on Lung Protection Following Thoracic Aorta Surgery With Hypothermic Circulatory Arrest: a Randomized Clinical Trial Completed NCT02678728 Phase 4 Dexmedetomidine;normal saline
25 Is There Any Effect of Meperidine on the Length of Duration of Labor? A Prospective Randomized Controlled Trial. Completed NCT01555671 Phase 4 Placebo;Meperidine
26 Pharmacokinetic/Pharmacodynamic Effects of add-on Antiplatelet Therapy With Parenteral Cangrelor as Compared to Standard Dual Antiplatelet Treatment in Patients With ST-elevation Myocardial Infarction Complicated by Out-of-hospital Cardiac Arrest and Treated With Targeted Temperature Management Recruiting NCT03273075 Phase 4 Cangrelor;Placebo;Prasugrel;Ticagrelor
27 Platelet Inhibition With Cangrelor in Comatose Survivors of Out-of-hospital Cardiac Arrest Undergoing Primary Percutaneous Coronary Intervention Recruiting NCT04005729 Phase 4 Cangrelor 50 MG
28 Randomized Multicentric Trial to Compare Efficacy and Security of Bucberg vs Del Nido Cardioplegic Solutions in Isolated Aortic Valve Replacement. Recruiting NCT04259515 Phase 4 Del Nido;Buckberg
29 Arrhythmia Prevention in High Risk Cardiovascular Patients Using Targeted Potassium Levels Recruiting NCT03833089 Phase 4
30 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial Active, not recruiting NCT02643381 Phase 4 Etomidate;Ketamine
31 CanROC Epinephrine Dose: Optimal Versus Standard Evaluation Trial (CanROC EpiDOSE Trial) Not yet recruiting NCT03826524 Phase 4 Epinephrine
32 Prehospital Laryngeal Tube vs. Bag-Valve Mask Ventilation Used by Paramedics During CPR- A Prospective, Controlled, Randomised, Multi-center Trial Terminated NCT01718795 Phase 4
33 Mild Induced Hypothermia to Treat Severe Community Acquired Meningitis in Adults Admitted to Intensive Care Unit Terminated NCT00774631 Phase 4
34 Neuroprotective Effect of Desflurane in the Experimental Study: the Impact if Desflurane Preconditioning on the Content of the Phosphorylated Form of GSK-3b in the Neurons of the Rat's Brain in the Model of Ischemia/Reperfusion Withdrawn NCT04287842 Phase 4 Desflurane;Sevoflurane
35 Pre Hospital Evaluation of Video Laryngoscopy : a Comparative Study of Macintosh and GLIDESCOPE Ranger® Withdrawn NCT01374061 Phase 4
36 LUcas Continuous Chest Compressions in Out-of-hospital Cardiac Arrest Treatment. The LUCAT Trial Unknown status NCT01521208 Phase 3
37 Hemodynamic Efficiency of an Hemodialysis Treatment With High Permeability (HDHP) During the Early Period of Post-resuscitation Shock Unknown status NCT00780299 Phase 3
38 A Multicentre Prospective Randomised Study Comparing the Efficacy of High Versus Low Biphasic Energy Defibrillation in Patients With Cardiac Arrest Unknown status NCT00429611 Phase 3
39 Arrested Versus Beating Heart Techniques in Coronary Revascularisation: Randomized Clinical Trial in Unselected Patients Unknown status NCT00999089 Phase 3
40 CYclosporine A in Non-shockable Out-of-hospital Cardiac Arrest ResUScitation Completed NCT01595958 Phase 3 Cyclosporine A
41 A Pilot Randomized Controlled Trial to Compare Fixed Versus Escalating Energy Regimens for Biphasic Waveform Defibrillation Completed NCT00212992 Phase 3
42 Automated External Defibrillator (AED) Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute" Completed NCT00139542 Phase 3
43 InterLeukine Ancillary Study of the Therapeutic Hypothermia After Nonshockable Cardiac Arrest Trial. Completed NCT02711098 Phase 3
44 Study of the Use of Mild Hypothermia in Out-of-hospital Cardiac Arrest Using a Rapid Infusion of 2 Liters of Cold Normal Saline Completed NCT00391469 Phase 2, Phase 3 Rapid infusion of cold normal saline
45 Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation (VF) or Ventricular Tachycardia (VT) Completed NCT01401647 Phase 3 amiodarone;Lidocaine
46 Fluid Shift in Patients Treated With Therapeutic Hypothermia After Cardiac Arrest, and How do They Manage Life Afterwards? Completed NCT00347477 Phase 3 HyperHAES vs. RA-solution/NaCl
47 Reduction of no Flow Time During Out of Hospital Cardiac Arrest by Using Laryngeal Tube for Airway Management by Nurses. Completed NCT01295749 Phase 3
48 Requirement of Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest - a Pilot Study Completed NCT01719770 Phase 3 rocuronium
49 Randomized Trial of Dispatcher-Assisted CPR:Chest Compression Alone Versus Chest Compression Plus Ventilation Completed NCT00219687 Phase 3
50 Therapeutic Hypothermia After Pediatric Cardiac Arrest (Out of Hospital) Completed NCT00878644 Phase 3

Search NIH Clinical Center for Cardiac Arrest

Inferred drug relations via UMLS 71 / NDF-RT 51 :

Atropine Sulfate
Calcium Chloride
Calcium gluceptate
Calcium Gluconate
epinephrine bitartrate
epinephrine hydrochloride
epinephryl borate
Methylatropine nitrate
Racepinephrine Hydrochloride
Sodium Bicarbonate

Cochrane evidence based reviews: heart arrest

Genetic Tests for Cardiac Arrest

Genetic tests related to Cardiac Arrest:

# Genetic test Affiliating Genes
1 Cardiac Arrest 29

Anatomical Context for Cardiac Arrest

MalaCards organs/tissues related to Cardiac Arrest:

Heart, Brain, Liver, Kidney, Spinal Cord, Endothelial, Thyroid

Publications for Cardiac Arrest

Articles related to Cardiac Arrest:

(show top 50) (show all 35522)
# Title Authors PMID Year
COVID-19, hydroxychloroquine and sudden cardiac death: implications for clinical practice in patients with rheumatic diseases. 42 61
33386447 2021
Cardiac arrest in older adult patients. 61 42
33369933 2021
Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial. 61 42
33433575 2021
Interpreting secondary cardiac disease variants in an exome cohort. 6
23861362 2013
Familial evaluation in arrhythmogenic right ventricular cardiomyopathy: impact of genetics and revised task force criteria. 6
21606390 2011
Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human. 6
12639993 2003
Neuron specific enolase and S-100B as predictors of outcome after cardiac arrest and induced hypothermia. 54 61
19467754 2009
Neuron-specific enolase and S-100B are associated with neurologic outcome after pediatric cardiac arrest. 54 61
19307814 2009
Predictive power of serum NSE and OHCA score regarding 6-month neurologic outcome after out-of-hospital ventricular fibrillation and therapeutic hypothermia. 54 61
18954930 2009
Serum neuron specific enolase to predict neurological outcome after cardiopulmonary resuscitation: a critically appraised topic. 54 61
19131859 2009
[Role of neuron specific enolase and S100 protein in evaluation of brain damage in patients resuscitated from cardiac arrest]. 54 61
18093437 2007
Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation. 54 61
17482335 2007
Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100. 61 54
17502328 2007
2006 Curt P. Richter award winner: Social influences on stress responses and health. 61 54
17590276 2007
Carnitine-acylcarnitine translocase deficiency in three neonates presenting with rapid deterioration and cardiac arrest. 54 61
17277394 2007
Oxidative stress reversibly inactivates myocardial enzymes during cardiac arrest. 54 61
16920803 2007
Cardiac ryanodine receptor gene (hRyR2) mutation underlying catecholaminergic polymorphic ventricular tachycardia in a Chinese adolescent presenting with sudden cardiac arrest and cardiac syncope. 54 61
17199967 2006
Allelic variants of SCN5A and risk of sudden cardiac arrest in patients with coronary artery disease. 54 61
16731473 2006
Disorders of carnitine transport and the carnitine cycle. 61 54
16602102 2006
Changes of cytoskeletal proteins in ischaemic brain under cardiac arrest and reperfusion conditions. 54 61
16823696 2006
Serum neuron-specific enolase as early predictor of outcome after in-hospital cardiac arrest: a cohort study. 61 54
16978415 2006
Ability of neuron-specific enolase to predict survival to hospital discharge after successful cardiopulmonary resuscitation. 54 61
17175624 2006
Outcome after cardiac arrest: predictive values and limitations of the neuroproteins neuron-specific enolase and protein S-100 and the Glasgow Coma Scale. 54 61
15797275 2005
Pulmonary haemorrhage and cardiac dysfunction in a neonate with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency. 54 61
15858970 2005
Up-regulation of a growth arrest and DNA damage protein (GADD34) in the ischaemic human brain: implications for protein synthesis regulation and DNA repair. 61 54
15541008 2004
[Stem cell mobilization after coronary artery bypass grafting]. 61 54
15253141 2004
Serum neuron-specific enolase and S-100B protein in cardiac arrest patients treated with hypothermia. 54 61
14631087 2003
Natural history of Brugada syndrome: insights for risk stratification and management. 54 61
11901046 2002
Serum levels of the brain-derived proteins S-100 and NSE predict long-term outcome after cardiac arrest. 54 61
11382525 2001
Apical hypertrophic cardiomyopathy due to a de novo mutation Arg719Trp of the beta-myosin heavy chain gene and cardiac arrest in childhood. A case report and family study. 54 61
10957787 2000
Time course of serum neuron-specific enolase. A predictor of neurological outcome in patients resuscitated from cardiac arrest. 61 54
10436107 1999
Monitoring of extracellular aspartate aminotransferase and troponin T by microdialysis during and after cardioplegic heart arrest. 54 61
10754346 1999
Creatine kinase-mb fraction and cardiac troponin T to diagnose acute myocardial infarction after cardiopulmonary resuscitation. 54 61
8890819 1996
Corticosteroid and immune responses to cardiac surgery. 61 54
8837293 1996
Creatine kinase and creatine kinase-MB release after nontraumatic cardiac arrest. 61 54
8610606 1996
[Hypoxic brain damage after prolonged cardiac arrest during anesthesia--changes in CT and serum NSE concentration]. 61 54
7933514 1994
CSF and serum brain-specific creatine kinase isoenzyme (CK-BB), neuron-specific enolase (NSE) and neural cell adhesion molecule (NCAM) as prognostic markers for hypoxic brain injury after cardiac arrest in man. 54 61
8509798 1993
Determinants of elevated creatine kinase activity and creatine kinase MB-fraction following cardiopulmonary resuscitation. 61 54
1582302 1992
Evaluation of hypoxic brain injury with spinal fluid enzymes, lactate, and pyruvate. 61 54
1541099 1992
Changes of neuron-specific enolase concentration in plasma after cardiac arrest and resuscitation. 61 54
1958265 1991
Effects of extreme temperatures, fine particles and ozone on hourly ambulance dispatches. 61
33071137 2021
Review of Hypothermia Protocol and Timing of the Echocardiogram. 61
33516091 2021
Present cum future of SARS-CoV-2 virus and its associated control of virus-laden air pollutants leading to potential environmental threat - A global review. 61
33462561 2021
Beating-heart total arch replacement for an octogenarian patient with severe heart failure. 61
33416189 2021
Factors Affecting Early Mortality and 1-Year Outcomes in Young Women With ST-Segment-Elevation Myocardial Infarction Aged Less Than or Equal to 45 Years. 61
31047713 2021
Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs. 61
33136260 2021
Brachiocephalic artery dissection is a marker of stroke after acute type A aortic dissection repair. 61
33442891 2021
MLWAVE: A novel algorithm to classify primary versus secondary asphyxia-associated ventricular fibrillation. 61
33569548 2021
Volumetric Capnography Monitoring and Effects of Epinephrine on Volume of Carbon Dioxide Elimination during Resuscitation after Cardiac Arrest in a Swine Pediatric Ventricular Fibrillatory Arrest. 61
33585059 2021
Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Before and During COVID in New York. 61
33301770 2021

Variations for Cardiac Arrest

ClinVar genetic disease variations for Cardiac Arrest:

6 (show all 37)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 DSP NM_004415.4(DSP):c.2821C>T (p.Arg941Ter) SNV Likely pathogenic 180326 rs730880082 6:7577219-7577219 6:7576986-7576986
2 CEP85L NM_002667.5(PLN):c.116T>G (p.Leu39Ter) SNV Likely pathogenic 13637 rs111033560 6:118880200-118880200 6:118559037-118559037
3 RYR2 NM_001035.3(RYR2):c.13759A>C (p.Ile4587Leu) SNV Uncertain significance 180504 rs730880198 1:237955600-237955600 1:237792300-237792300
4 VCL NM_014000.2(VCL):c.1559G>A (p.Arg520Gln) SNV Uncertain significance 222888 rs757009736 10:75855429-75855429 10:74095671-74095671
5 DSP NM_004415.4(DSP):c.2260G>A (p.Glu754Lys) SNV Uncertain significance 180323 rs730880080 6:7574448-7574448 6:7574215-7574215
6 MYH6 NM_002471.3(MYH6):c.4713G>T (p.Lys1571Asn) SNV Uncertain significance 180427 rs730880151 14:23855770-23855770 14:23386561-23386561
7 NSUN6 NM_201596.3(CACNB2):c.1642G>A (p.Gly548Ser) SNV Uncertain significance 180290 rs730880059 10:18828312-18828312 10:18539383-18539383
8 NSUN6 NM_201596.3(CACNB2):c.1206+3A>T SNV Uncertain significance 180291 rs200174877 10:18823159-18823159 10:18534230-18534230
9 AKAP9 NM_005751.4(AKAP9):c.1099G>A (p.Val367Met) SNV Uncertain significance 180260 rs138161478 7:91630330-91630330 7:92001016-92001016
10 AKAP9 NM_005751.4(AKAP9):c.11378C>G (p.Ser3793Cys) SNV Uncertain significance 180266 rs730880044 7:91735039-91735039 7:92105725-92105725
11 ANK2 NM_001148.6(ANK2):c.6206G>A (p.Arg2069His) SNV Uncertain significance 180270 rs149645600 4:114275980-114275980 4:113354824-113354824
12 AKAP9 NM_005751.4(AKAP9):c.1067A>T (p.Asp356Val) SNV Uncertain significance 222487 rs533277424 7:91630298-91630298 7:92000984-92000984
13 NSUN6 NM_201596.3(CACNB2):c.1594T>G (p.Ser532Ala) SNV Uncertain significance 222520 rs869025371 10:18828264-18828264 10:18539335-18539335
14 SCN5A NM_198056.2(SCN5A):c.559A>G (p.Thr187Ala) SNV Uncertain significance 222801 rs869025517 3:38662386-38662386 3:38620895-38620895
15 HCN4 NM_005477.3(HCN4):c.2197G>A (p.Val733Ile) SNV Uncertain significance 222648 rs376631391 15:73616237-73616237 15:73323896-73323896
16 ANK2 NM_001148.6(ANK2):c.5509G>A (p.Ala1837Thr) SNV Uncertain significance 222498 rs199527708 4:114275283-114275283 4:113354127-113354127
17 SLMAP NM_007159.4(SLMAP):c.1918+1G>A SNV Uncertain significance 222824 rs869025527 3:57898429-57898429 3:57912702-57912702
18 DSG2 NM_001943.5(DSG2):c.437G>T (p.Arg146Leu) SNV Uncertain significance 44317 rs113451409 18:29101120-29101120 18:31521157-31521157
19 TRPM4 NM_017636.4(TRPM4):c.1069C>T (p.Arg357Trp) SNV Uncertain significance 222852 rs764690335 19:49675284-49675284 19:49172027-49172027
20 DSG2 NM_001943.5(DSG2):c.1063G>A (p.Ala355Thr) SNV Uncertain significance 191629 rs201046640 18:29110998-29110998 18:31531035-31531035
21 DSP NM_004415.4(DSP):c.2047G>A (p.Glu683Lys) SNV Uncertain significance 222574 rs775181391 6:7572218-7572218 6:7571985-7571985
22 ANK2 NM_001148.6(ANK2):c.7458C>G (p.His2486Gln) SNV Uncertain significance 222502 rs776972443 4:114277232-114277232 4:113356076-113356076
23 DSP NM_004415.4(DSP):c.7249G>T (p.Asp2417Tyr) SNV Uncertain significance 222585 rs760501352 6:7584744-7584744 6:7584511-7584511
24 MYOM1 NM_003803.3(MYOM1):c.3708C>A (p.Ser1236Arg) SNV Uncertain significance 222745 rs869025489 18:3100176-3100176 18:3100178-3100178
25 RYR2 NM_001035.3(RYR2):c.378T>A (p.Ser126Arg) SNV Uncertain significance 222783 rs869025507 1:237532902-237532902 1:237369602-237369602
26 KCNJ8 NM_004982.4(KCNJ8):c.83G>C (p.Arg28Pro) SNV Uncertain significance 222678 rs768851540 12:21926468-21926468 12:21773534-21773534
27 DSG2-AS1 NM_001943.5(DSG2):c.2188A>G (p.Thr730Ala) SNV Uncertain significance 222564 rs780650226 18:29122669-29122669 18:31542706-31542706
28 AKAP9 NM_005751.4(AKAP9):c.11276C>T (p.Pro3759Leu) SNV Uncertain significance 222492 rs869025356 7:91732086-91732086 7:92102772-92102772
29 ANK2 NM_001148.6(ANK2):c.7577C>T (p.Ser2526Leu) SNV Uncertain significance 222503 rs762909298 4:114277351-114277351 4:113356195-113356195
30 SCN5A NM_001099404.1(SCN5A):c.5075T>C (p.Phe1692Ser) SNV Uncertain significance 222813 rs869025521 3:38592788-38592788 3:38551297-38551297
31 DPP6 NM_130797.4(DPP6):c.1039G>A (p.Ala347Thr) SNV Uncertain significance 222554 rs770646362 7:154564555-154564555 7:154772845-154772845
32 TTN NM_001267550.2(TTN):c.29230C>T (p.Arg9744Cys) SNV Likely benign 46820 rs375266859 2:179571371-179571371 2:178706644-178706644
33 CACNA2D1 NM_000722.4(CACNA2D1):c.2264G>C (p.Ser755Thr) SNV Likely benign 180288 rs151327713 7:81599241-81599241 7:81969925-81969925
34 DSC2 NM_024422.6(DSC2):c.1073C>T (p.Thr358Ile) SNV Likely benign 46160 rs139399951 18:28662896-28662896 18:31082930-31082930
35 MYBPC3 NM_000256.3(MYBPC3):c.3392T>C (p.Ile1131Thr) SNV Likely benign 42711 rs370890951 11:47354463-47354463 11:47332912-47332912
36 SCN5A NM_000335.5(SCN5A):c.1715C>A (p.Ala572Asp) SNV Likely benign 67683 rs36210423 3:38645378-38645378 3:38603887-38603887
37 RBM20 NM_001134363.3(RBM20):c.2662G>A (p.Asp888Asn) SNV Benign 43995 rs201370621 10:112581039-112581039 10:110821281-110821281

Expression for Cardiac Arrest

Search GEO for disease gene expression data for Cardiac Arrest.

Pathways for Cardiac Arrest

Pathways related to Cardiac Arrest according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
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GO Terms for Cardiac Arrest

Cellular components related to Cardiac Arrest according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.67 SCN5A RYR2 MYH7 CASQ2
2 sarcoplasmic reticulum GO:0016529 9.56 TRDN RYR2 PLN CASQ2
3 calcium channel complex GO:0034704 9.5 RYR2 CASQ2 CALM1
4 myosin filament GO:0032982 9.46 MYH7 MYBPC3
5 sarcoplasmic reticulum lumen GO:0033018 9.43 TRDN CASQ2
6 cardiac myofibril GO:0097512 9.4 TNNT2 MYBPC3
7 junctional sarcoplasmic reticulum membrane GO:0014701 9.33 TRDN RYR2 CASQ2
8 sarcoplasmic reticulum membrane GO:0033017 9.26 TRDN RYR2 PLN CASQ2
9 sarcomere GO:0030017 9.02 TNNT2 RYR2 MYH7 MYBPC3 CALM1

Biological processes related to Cardiac Arrest according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.89 TRDN SCN5A RYR2 KCNH2 CASQ2
2 cellular calcium ion homeostasis GO:0006874 9.81 TRDN RYR2 PLN
3 muscle contraction GO:0006936 9.78 TRDN TNNT2 MYH7 CALM1
4 regulation of cardiac conduction GO:1903779 9.71 TRDN RYR2 CASQ2
5 regulation of heart rate by cardiac conduction GO:0086091 9.7 SCN5A KCNH2 DSP
6 muscle filament sliding GO:0030049 9.69 TNNT2 MYH7 MYBPC3
7 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.64 PLN CALM1
8 regulation of release of sequestered calcium ion into cytosol GO:0051279 9.64 TRDN CASQ2
9 membrane depolarization during action potential GO:0086010 9.63 SCN5A KCNH2
10 heart contraction GO:0060047 9.62 TRDN ACE
11 striated muscle contraction GO:0006941 9.62 MYH7 CASQ2
12 regulation of cardiac muscle cell contraction GO:0086004 9.61 SCN5A PLN
13 negative regulation of ATPase activity GO:0032780 9.61 TNNT2 PLN
14 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.61 TNNT2 MYH7 MYBPC3
15 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.6 RYR2 DSP
16 regulation of membrane repolarization GO:0060306 9.59 KCNH2 CASQ2
17 cellular response to caffeine GO:0071313 9.58 RYR2 CASQ2
18 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.58 TRDN CALM1
19 ventricular cardiac muscle cell action potential GO:0086005 9.58 SCN5A RYR2 KCNH2
20 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 9.57 TRDN RYR2
21 regulation of cell communication by electrical coupling GO:0010649 9.56 TRDN CASQ2
22 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.56 RYR2 PLN CASQ2 CALM1
23 regulation of cardiac muscle cell membrane potential GO:0086036 9.55 TRDN PLN
24 detection of calcium ion GO:0005513 9.54 RYR2 CASQ2 CALM1
25 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 TRDN CASQ2 CALM1
26 Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 9.46 RYR2 CASQ2
27 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.46 TRDN PLN CASQ2 CALM1
28 regulation of heart rate GO:0002027 9.35 SCN5A RYR2 MYH7 CASQ2 CALM1
29 cardiac muscle contraction GO:0060048 9.17 TNNT2 SCN5A RYR2 MYH7 MYBPC3 KCNH2

Molecular functions related to Cardiac Arrest according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TRDN TNNT2 SLC25A20 SCN5A S100B RYR2
2 nitric-oxide synthase binding GO:0050998 9.37 SCN5A CALM1
3 calcium-dependent protein binding GO:0048306 9.33 S100B CASQ2 CALM1
4 titin binding GO:0031432 9.32 MYBPC3 CALM1
5 scaffold protein binding GO:0097110 9.13 SCN5A KCNH2 DSP
6 ion channel binding GO:0044325 8.92 TRDN SCN5A RYR2 CALM1

Sources for Cardiac Arrest

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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