Aliases & Classifications for Cardiac Arrhythmia

MalaCards integrated aliases for Cardiac Arrhythmia:

Name: Cardiac Arrhythmia 57 29 6 17
Adverse Event Associated with Cardiac Arrhythmia 71
Premature Cardiac Complex 71
Cardiac Arrhythmias 6
Extrasystoles 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant


HPO:

31
cardiac arrhythmia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 115000
ICD10 32 I49.8 I49.9
MedGen 41 C0003811
SNOMED-CT via HPO 68 263681008 26636000 88425004
UMLS 71 C0340464 C1560249

Summaries for Cardiac Arrhythmia

MalaCards based summary : Cardiac Arrhythmia, also known as adverse event associated with cardiac arrhythmia, is related to cardiac arrhythmia, ankyrin-b-related and long qt syndrome 14, and has symptoms including pulsus trigeminus and bigeminal pulse. An important gene associated with Cardiac Arrhythmia is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Cardiac conduction and cGMP-PKG signaling pathway. The drugs Moxifloxacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related phenotypes are abnormality of the nervous system and sudden death

More information from OMIM: 115000

Related Diseases for Cardiac Arrhythmia

Diseases related to Cardiac Arrhythmia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 576)
# Related Disease Score Top Affiliating Genes
1 cardiac arrhythmia, ankyrin-b-related 32.5 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 ANK2
2 long qt syndrome 14 31.9 SCN5A KCNQ1 KCNH2
3 long qt syndrome 11 31.9 KCNQ1 KCNE2 ANK2
4 arrhythmogenic right ventricular dysplasia, familial, 8 31.7 RYR2 PKP2 DSP
5 long qt syndrome 9 31.7 SCN5A KCNQ1 KCNH2 KCNE2 ANK2
6 ventricular fibrillation, paroxysmal familial, 1 31.7 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 DSP
7 long qt syndrome 12 31.7 SCN5A KCNQ1 KCNH2 KCNE2 ANK2
8 long qt syndrome 13 31.7 SCN5A KCNQ1 KCNH2 KCNE2 ANK2
9 long qt syndrome 5 31.7 SCN5A KCNQ1 KCNH2 KCNE2 ANK2
10 andersen cardiodysrhythmic periodic paralysis 31.5 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 ANK2
11 syncope 31.0 SCN5A RYR2 KCNQ1 KCNH2
12 atrioventricular block 30.9 SCN5A RYR2 KCNQ1 KCNH2 KCNE2
13 progressive familial heart block, type ia 30.8 SCN5A DSP ANK2
14 brugada syndrome 4 30.8 SCN5A KCNQ1 KCNH2
15 cardiac conduction defect 30.8 SCN5A SCN1B RYR2 KCNQ1 KCNH2 DSP
16 brugada syndrome 3 30.7 KCNE2 CACNA1C-AS1 ANK2
17 cardiac arrest 30.7 SCN5A RYR2 KCNQ1 KCNH2 DSP ANK2
18 atrial fibrillation 30.6 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
19 idiopathic ventricular fibrillation, non brugada type 30.6 SCN5A RYR2
20 brugada syndrome 1 30.5 SCN5A RYR2 LOC110121269 KCNH2
21 first-degree atrioventricular block 30.5 SCN5A KCNH2
22 left bundle branch hemiblock 30.4 SCN5A RYR2 PKP2 DSP
23 brugada syndrome 5 30.4 SCN5A SCN1B
24 familial short qt syndrome 30.4 KCNQ1 KCNH2
25 third-degree atrioventricular block 30.2 SCN5A SCN1B KCNH2
26 sick sinus syndrome 1 30.1 SCN5A LOC110121269
27 arrhythmogenic right ventricular cardiomyopathy 30.0 SCN5A RYR2 PKP2 KCNH2 DSP ANK2
28 noonan syndrome with multiple lentigines 30.0 SCN5A RYR2 KCNQ1 KCNH2
29 atrial standstill 1 30.0 SCN5A SCN1B RYR2 PKP2 DSP
30 heart disease 29.9 SCN5A RYR2 PKP2 KCNQ1 KCNH2 KCNE2
31 long qt syndrome 6 29.9 SCN5A KCNQ1 KCNH2 KCNE2 ANK2
32 short qt syndrome 29.7 SCN5A RYR2 KCNQ1OT1 KCNQ1-AS1 KCNQ1 KCNH2
33 familial long qt syndrome 29.7 SCN5A LOC110121269 KCNQ1OT1 KCNQ1-AS1 KCNQ1 KCNH2
34 second-degree atrioventricular block 29.6 SCN5A SCN3B
35 sick sinus syndrome 29.6 SCN5A SCN3B SCN1B RANGRF LOC110121269 ANK2
36 lipoprotein quantitative trait locus 29.5 SCN5A RYR2 PKP2 KCNQ1 KCNH2 KCNE2
37 hypertrophic cardiomyopathy 29.5 SCN5A RYR2 PKP2 KCNQ1 KCNH2 KCNE2
38 timothy syndrome 29.5 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 CACNA1C-AS1
39 dilated cardiomyopathy 29.4 SCN5A RYR2 PKP2 KCNQ1 KCNH2 KCNE2
40 jervell and lange-nielsen syndrome 1 29.3 SCN5A KCNQ1OT1 KCNQ1-AS1 KCNQ1 KCNH2 KCNE2
41 right bundle branch block 29.2 SCN5A SCN3B SCN1B RANGRF PKP2 KCNH2
42 sinoatrial node disease 29.2 SCN5A SCN3B SCN1B RYR2 RANGRF KCNQ1
43 long qt syndrome 3 29.2 SCN5A SCN3B SCN1B RYR2 LOC110121269 KCNQ1
44 long qt syndrome 2 29.1 SCN5A SCN3B SCN1B RYR2 PKP2 KCNQ1
45 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 29.1 SCN5A RYR2 PKP2 KCNQ1 KCNH2 DTNA
46 sudden infant death syndrome 29.1 SCN5A SCN3B SCN1B RYR2 LOC110121269 KCNQ1
47 early infantile epileptic encephalopathy 29.1 SCN5A SCN3B SCN1B KCNQ1 KCNH2
48 catecholaminergic polymorphic ventricular tachycardia 28.8 SCN5A SCN3B SCN1B RYR2 PKP2 KCNQ1
49 long qt syndrome 28.5 SCN5A SCN3B SCN1B RYR2 PKP2 LOC110121269
50 brugada syndrome 28.3 SCN5A SCN3B SCN1B RYR2 RANGRF PKP2

Comorbidity relations with Cardiac Arrhythmia via Phenotypic Disease Network (PDN):


Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Sinoatrial Node Disease

Graphical network of the top 20 diseases related to Cardiac Arrhythmia:



Diseases related to Cardiac Arrhythmia

Symptoms & Phenotypes for Cardiac Arrhythmia

Human phenotypes related to Cardiac Arrhythmia:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707
2 sudden death 31 HP:0001699
3 polymorphic and polytopic ventricular extrasystoles 31 HP:0006696

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Cardiac:
arrhythmia
polymorphic and polytopic ventricular extrasystoles

Neuro:
syncopal attacks

Misc:
sudden death

Clinical features from OMIM®:

115000 (Updated 05-Mar-2021)

UMLS symptoms related to Cardiac Arrhythmia:


pulsus trigeminus, bigeminal pulse

MGI Mouse Phenotypes related to Cardiac Arrhythmia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 CAPN3 DSP DTNA GNB5 KCNH2 KCNQ1
2 muscle MP:0005369 9.32 CAPN3 DSP DTNA GNB5 KCNH2 KCNQ1

Drugs & Therapeutics for Cardiac Arrhythmia

Drugs for Cardiac Arrhythmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
4
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
5
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
6
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
7
Ajmaline Approved, Experimental Phase 4 4360-12-7 441080
8
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
9
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
10
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
11
Procainamide Approved Phase 4 51-06-9 4913
12 Anti-Bacterial Agents Phase 4
13 Norgestimate, ethinyl estradiol drug combination Phase 4
14 Anti-Asthmatic Agents Phase 4
15 Adrenergic beta-Agonists Phase 4
16 Epinephryl borate Phase 4
17 Narcotics Phase 4
18 Mydriatics Phase 4
19 Analgesics, Opioid Phase 4
20 Anesthetics, Local Phase 4
21 Sympathomimetics Phase 4
22 Anesthetics, General Phase 4
23 Anesthetics, Intravenous Phase 4
24 Bronchodilator Agents Phase 4
25 Vasoconstrictor Agents Phase 4
26 Adrenergic alpha-Agonists Phase 4
27 Neurotransmitter Agents Phase 4
28 Analgesics Phase 4
29 Anesthetics Phase 4
30 Adrenergic Agents Phase 4
31 Adrenergic Agonists Phase 4
32 Sodium Channel Blockers Phase 4
33 Diuretics, Potassium Sparing Phase 4
34 Anti-Arrhythmia Agents Phase 4
35 Analgesics, Non-Narcotic Phase 4
36 Hypnotics and Sedatives Phase 4
37 Calcium, Dietary Phase 4
38 Anticonvulsants Phase 4
39 Cytochrome P-450 Enzyme Inhibitors Phase 4
40 Hormones Phase 4
41 Cytochrome P-450 CYP3A Inhibitors Phase 4
42 calcium channel blockers Phase 4
43 Vasodilator Agents Phase 4
44 Tocolytic Agents Phase 4
45 Potassium Channel Blockers Phase 4
46
Calcium Nutraceutical Phase 4 7440-70-2 271
47
Galantamine Approved Phase 3 357-70-0 9651
48
Ranolazine Approved, Investigational Phase 3 95635-55-5, 142387-99-3 56959
49
Warfarin Approved Phase 3 81-81-2 6691 54678486
50
Dalteparin Approved Phase 3 9005-49-6

Interventional clinical trials:

(show top 50) (show all 139)
# Name Status NCT ID Phase Drugs
1 Genetics of QT Response to Moxifloxacin Unknown status NCT01936480 Phase 4 Moxifloxacin 400mg once time;Placebo
2 Evaluation of Cardiac Arrhythmias in Patients Undergoing Kidney Cancer Surgery Depending on the Anaesthesia Method Completed NCT02988219 Phase 4 Bupivacaine-fentanyl
3 Hemodynamic and Electrocardiographic Effects of Hyaluronidase Associated With Local Anaesthetics: a Double-blind "Split-mouth" Controlled Trial. Completed NCT01719978 Phase 4 3.6mL 2% Mepivacaine with 1:100,000 epinephrine;Hyaluronidase;Placebo
4 CRYptogenic STroke And underLying AF Trial Completed NCT00924638 Phase 4
5 Ajmaline Utilization in the Diagnosis and Treatment of Cardiac Arrhythmias Completed NCT00702117 Phase 4 flecainide;ajmaline;procainamide
6 Multicenter Study for the Prevention of Post-Operative Cardiac Arrhythmias Not yet recruiting NCT04234906 Phase 4 Dexmedetomidine;Magnesium Sulfate;Amiodarone;Procainamide
7 Placebo-Controlled Evaluation of Galantamine in the Treatment of Alzheimer's Disease: A Cardiac Safety Study. Completed NCT00309725 Phase 3 galantamine
8 Influence of a Specific Micronutrient Combination on Symptom Awareness and Heart Rhythm in Patients With Cardiac Arrhythmia Completed NCT02652338 Phase 3
9 Cardiac Arrhythmia Suppression Trial (CAST) Completed NCT00000526 Phase 3 encainide;flecainide;moricizine
10 The Effect of Ranolazine on Cardiac Arrhythmias and Microvolt T- Wave Alternans in Patients With Significant Left Ventricular Dysfunction Completed NCT00998218 Phase 3 Ranolazine;Placebo
11 An Open-Label Randomized Control Trial of Pre-Operative Low Molecular Weight Heparin Versus Tapered Warfarin as Bridging Therapy for Patients With Implantation of Pacemaker or Defibrillator Terminated NCT02094157 Phase 3 Tapered warfarin regimen;Bridged regimen Low-molecular-weight heparin
12 Remote Intracardiac Catheter Target Acquisition Using the Magnetecs Catheter Guidance Control and Imaging (CGCI) System Unknown status NCT01222156 Phase 1, Phase 2
13 Sleep in Cardiac Patients With Implantable Cardioverter Defibrillators (ICD) Completed NCT02232204 Phase 2
14 Patient and Intimate Partner Intervention to Improve Outcomes After an ICD Completed NCT01252615 Phase 2
15 Cardiac Arrhythmia Pilot Study (CAPS) Completed NCT00000504 Phase 2 encainide;moricizine;flecainide;imipramine
16 Cardiac Arrhythmia Catheter Ablation Procedures Guided by x-Ray Imaging: N-Acetylcysteine Protection Against Radiation Induced Cellular damagE (CARAPACE Study) Recruiting NCT04154982 Phase 2 Acetyl cysteine
17 A Randomized, Placebo-controlled, Dose-range Finding Study to Assess the Pharmacokinetic and Pharmacodynamic Parameters, Safety, Tolerability, and Immunogenicity of MAA868 in Patients With Atrial Fibrillation Active, not recruiting NCT04213807 Phase 2
18 Clinical Evaluation of the CARTO™ XP EP Navigation System v9 and Biosense Webster SOUNDSTAR 3D Diagnostic Ultrasound. A Feasibility Study Withdrawn NCT00449085 Phase 2
19 STTR Phase II : Skin Sympathetic Nerve Activity and Cardiac Arrhythmias Withdrawn NCT02939469 Phase 2
20 Occurrence of Heart Arrhythmia During Restorative Dental Procedure Under Local Anesthesia , in Heart Failure Pacients. A Double-blind Study Unknown status NCT02228083 Lidocaine with epinephrine
21 Pilot Clinical Study of the Sleuth Implantable ECG Monitoring System Unknown status NCT00719277
22 Observational Study of the Sleuth Implantable ECG Monitoring System Unknown status NCT00717106
23 Documentation of Cardiac Arrhythmias After Open Heart Surgery Unknown status NCT02657590
24 A Prospective Randomized Study on the Effect of Oesophageal Temperature Monitoring on the Incidence of Esophageal Lesions After Left Atrial Ablation for the Treatment of Atrial Fibrillation. Unknown status NCT03645070
25 European Pediatric Catheter Ablation Registry Unknown status NCT01691573
26 ENHANCED Device Programming to Reduce Therapies and Improve Quality of Life in Implantable Cardioverter Defibrillator Patients: A Prospective, Single-arm Safety Monitoring Study (ENHANCED-ICD Study) Unknown status NCT01715116
27 Use of the Rhytmia System for Determining the Precise Location and Potential Mechanism of Premature Ventricular Contractions Unknown status NCT03460535
28 Optimizing Diagnostics And Therapy Of Arrhythmia And Syncope Events Using Intelligent Telemetric Solutions. Diagnostics Of Syncope In Children. Unknown status NCT01265290
29 Same Day Discharge Unknown status NCT02943512
30 Metabolism of Patients With Genetically Caused Cardiac Arrhythmia Unknown status NCT02775513
31 Identification of Predictors of Cardiac Arrhythmias and Sudden Death in Pediatric Patients Affected With Laminopathies Unknown status NCT02601066
32 Effect of High-dose Caffeine on Cardiac Arrhythmias in Patients With Heart Failure - a Randomized Clinical Trial Unknown status NCT02045992
33 Risk Assessment of Cardiac ARrhythmias in Patients With MYocarditis Unknown status NCT03801681
34 Effects of Endurance Training on Patients With Reduced LVEF and Cardiac Resynchronisation Therapy Especially for Cardiac Arrhythmias Unknown status NCT00472238
35 Post-Extrasystolic Potentiation as a Predictor of Ventricular Arrhythmias Unknown status NCT03631303
36 Development of a Novel Convolution Neural Network for Arrhythmia Classification for Shockable Cardiac Rhythms Completed NCT03662802
37 Esophageal 3D Mapping System for Cardiac Arrhythmias: Pilot Study to Establish Basis for Improved Arrhythmia Diagnostics Using the esoECG-3D Catheter Completed NCT03365440
38 MRI Assessment of Arrythmia Ablation Lesions Completed NCT02761343
39 Evaluating Myocardial Injury During ICD Implantation Using the Upper Limit of Vulnerability (ULV) Method vs. Standard Defibrillation Threshold Testing Completed NCT02111993
40 The Comparison of Serum Potassium Concentration, Antiarrhythmic Effect, and Myocardial Protective Effect Between Dexmedetomidine and Remifentanil Infusion in Patients Undergoing Coronary Artery Bypass Surgery Completed NCT01572454 Dexmedetomidine infusion;Remifentanil infusion
41 Prospective Registry on User Experience With The Mapping System For Ablation Procedures Completed NCT02698670
42 FREEDOM - A Frequent Optimization Study Using the QuickOpt Method Completed NCT00418314
43 Correlations Between Arrhythmias, Climatic Variables and Air Pollution in Patients With Pacemaker and ICD, Followed by Remote Monitoring. Completed NCT01723761
44 EnSite Precision™ Cardiac Mapping System and EnSite Precision™ Software v2.0 Observational Registry Completed NCT02757430
45 The Circadian Rhythm of Potassium and Cystatin c and the Day-to-day Variability Completed NCT01318746
46 4P Study: A Prospective Study on Predictive Quality Preferring PainFree Therapies Completed NCT01509378
47 The Efficacy of Adapted Yoga in Managing Psychosocial Risk in Implantable Cardioverter Defibrillator (ICD) Patients Completed NCT01716351
48 Electroanatomical Mapping of Patients Undergoing Catheter Ablation Procedures Using Rhythmia Mapping System and Catheter Completed NCT01642537
49 Clinical Utility and Validation of the Rhythmia Mapping System for the Treatment of Cardiac Arrhythmias Completed NCT03094221
50 Long Term Monitoring to Detect Risk of Sudden Death in Inherited Arrhythmia Patients Completed NCT04124237

Search NIH Clinical Center for Cardiac Arrhythmia

Genetic Tests for Cardiac Arrhythmia

Genetic tests related to Cardiac Arrhythmia:

# Genetic test Affiliating Genes
1 Cardiac Arrhythmia 29

Anatomical Context for Cardiac Arrhythmia

MalaCards organs/tissues related to Cardiac Arrhythmia:

40
Heart, Lung, Brain, Liver, Kidney, Thyroid, Skin

Publications for Cardiac Arrhythmia

Articles related to Cardiac Arrhythmia:

(show top 50) (show all 5795)
# Title Authors PMID Year
1
Familial paroxysmal ventricular tachycardia in two sisters. 57
4129426 1974
2
Fatal familial cardiac arrhythmias. Histologic observations on the cardiac conduction system. 57
5016833 1972
3
FAMILIAL POLYTOPIC AND POLYMORPHIC EXTRASYSTOLES. 57
14115011 1964
4
The focal adhesion protein Testin modulates KCNE2 potassium channel β subunit activity. 61
33464998 2021
5
Bedaquiline for multidrug-resistant tuberculosis and QTc prolongation in California. 61
33598568 2021
6
Ablation Success in Various Arrhythmias: When It Is Appropriate to Recommend Ablation? 61
33412347 2021
7
Influence of gamma radiation on Amphotericin B incorporated in PVP hydrogel as an alternative treatment for cutaneous leishmaniosis. 61
33387468 2021
8
The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. 61
33597309 2021
9
A Fatal Case of Cardiac Contusion After Blunt Chest Injury. 61
32732593 2021
10
Ionic basis of atrioventricular conduction: ion channel expression and sarcolemmal ion currents of the atrioventricular canal of the rainbow trout (Oncorhynchus mykiss) heart. 61
33575867 2021
11
Fitness to Drive After Syncope and/or in Cardiovascular Disease - An Overview and Practical Advice. 61
32888697 2021
12
The increased risk of atrial fibrillation in inflammatory arthritis: a systematic review and meta-analysis of cohort studies. 61
33563055 2021
13
High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice. 61
33525071 2021
14
Common Variants in KCNE1, KCNH2, and SCN5A May Impact Cardiac Arrhythmia Risk. 61
33517668 2021
15
Sarcopenia, sarcopenic overweight/obesity and risk of cardiovascular disease and cardiac arrhythmia: A cross-sectional study. 61
32593523 2021
16
Smoking Accelerates Atrioventricular Conduction in Humans Concordant with Increased Dopamine Release. 61
33043409 2021
17
Atrial fibrillation ablation: is common practice far from guidelines' world? The Italian experience from a national survey. 61
33566236 2021
18
Readmission and complications after robotic surgery: experience of 10,000 operations at a comprehensive cancer center. 61
32277400 2021
19
Fetal cardiomyocyte phenotype, ketone body metabolism, and mitochondrial dysfunction in the pathology of atrial fibrillation. 61
33188453 2021
20
Utility Decrements Associated With Diabetes and Related Complications: Estimates From a Population-Based Study in Germany. 61
33518034 2021
21
Using Medicare Data to Assess the Proarrhythmic Risk of Non-Cardiac Treatment Drugs that Prolong the QT Interval in Older Adults: An Observational Cohort Study. 61
33569737 2021
22
Disease-linked super-trafficking of a potassium channel. 61
33600800 2021
23
Challenges and opportunities for integrating genetic testing into a diagnostic workflow: heritable long QT syndrome as a model. 61
31287796 2021
24
Sodium channel β1 subunits participate in regulated intramembrane proteolysis-excitation coupling. 61
33411695 2021
25
Usefulness of Perioperative Laboratory Tests in Total Hip and Knee Arthroplasty: Are They Necessary for All Patients? 61
33553540 2021
26
Association of ACE2 variant rs4646188 with the risks of atrial fibrillation and cardioembolic stroke in Uygur patients with type 2 diabetes. 61
33602129 2021
27
[Fatal course of COVID-19 despite IL-6 receptor blockade in cytokine storm : Perimyocarditis and coagulopathy after administration of tocilizumab]. 61
33064176 2021
28
[Treatment of Heavily Calcified Coronary Lesions]. 61
33538631 2021
29
Reference values of electrographic and cardiac ultrasound parameters in Russian healthy children and adolescents. 61
33536510 2021
30
A standardized definition of near-fatal child maltreatment: Results of a multidisciplinary Delphi process. 61
33373847 2021
31
A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial. 61
33546739 2021
32
Nitric Oxide Produced by the Antioxidant Activity of Verapamil Improves the Acute Wound Healing Process. 61
33515165 2021
33
Spen deficiency interferes with Connexin 43 expression and leads to heart failure in zebrafish. 61
33549680 2021
34
Mitigating arrhythmia risk in Hydroxychloroquine and Azithromycin treated COVID-19 patients using arrhythmia risk management plan. 61
33335973 2021
35
Inhibition of Brainstem Endoplasmic Reticulum Stress Rescues Cardiorespiratory Dysfunction in High Output Heart Failure. 61
33307852 2021
36
Final-year nursing students' foundational knowledge and self-assessed confidence in interpreting cardiac arrhythmias: A cross-sectional study. 61
33341065 2021
37
Global epidemiology of atrial fibrillation: An increasing epidemic and public health challenge. 61
31955707 2021
38
Molecular dynamics of hERG channel: insights into understanding the binding of small molecules for detuning cardiotoxicity. 61
33494645 2021
39
Tracheostomy in patients with COVID-19: predictors and clinical features. 61
33386436 2021
40
Newer Diagnostic and Cost-Effective Ways to Identify Asymptomatic Atrial Fibrillation for the Prevention of Stroke. 61
33552757 2021
41
Actin-granule formation is an additional step in cardiac myofibroblast differentiation. 61
33569467 2021
42
Stereotactic Ablative radiation therapy (SABR) for cardiac arrhythmia: A new therapeutic option? 61
32405924 2021
43
Comparison of transvenous vs subcutaneous defibrillator therapy in patients with cardiac arrhythmia syndromes and genetic cardiomyopathies. 61
32871189 2021
44
Cardiac Arrhythmia During Early-Week and Mid-Week Dialysis in Hemodialysis Patients. 61
33470546 2021
45
Automated detection of arrhythmia from electrocardiogram signal based on new convolutional encoded features with bidirectional long short-term memory network classifier. 61
33405209 2021
46
Advances in the role and mechanism of BAG3 in dilated cardiomyopathy. 61
31808029 2021
47
Correcting hypophosphataemia in a paediatric patient with Sanjad-Sakati syndrome through a single oral dose of potassium phosphate intravenous solution. 61
33505699 2021
48
The role of calcium homeostasis remodeling in inherited cardiac arrhythmia syndromes. 61
33404893 2021
49
SARS-CoV-2: influence of phosphate and magnesium, moderated by vitamin D, on energy (ATP) metabolism and on severity of COVID-19. 61
33174766 2021
50
Cadherin-11 deficiency mitigates high-fat diet-induced inflammatory atrial remodeling and vulnerability to atrial fibrillation. 61
33452701 2021

Variations for Cardiac Arrhythmia

ClinVar genetic disease variations for Cardiac Arrhythmia:

6 (show top 50) (show all 1923)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 KCNQ1 NM_000218.2(KCNQ1):c.165_187del (p.Gly57fs) Deletion Pathogenic 200889 rs794728563 11:2466490-2466512 11:2445260-2445282
2 KCNH2 NM_000238.4(KCNH2):c.2966-2_2967dup Duplication Pathogenic 200691 rs794728464 7:150644600-150644601 7:150947512-150947513
3 KCNQ1 NM_000218.3(KCNQ1):c.153C>A (p.Tyr51Ter) SNV Pathogenic 933168 11:2466481-2466481 11:2445251-2445251
4 KCNH2 NM_000238.3(KCNH2):c.3096_3099dup (p.Pro1034fs) Duplication Pathogenic 200699 rs794728467 7:150644468-150644469 7:150947380-150947381
5 SCN3B NM_018400.3(SCN3B):c.423C>G (p.Ile141Met) SNV Pathogenic 224720 rs879253730 11:123513176-123513176 11:123642468-123642468
6 DSP NM_004415.4(DSP):c.2528C>A (p.Ser843Ter) SNV Pathogenic 374137 rs1057518920 6:7575619-7575619 6:7575386-7575386
7 KCNQ1 NM_000218.3(KCNQ1):c.1356del (p.Leu453fs) Deletion Pathogenic 922607 11:2610046-2610046 11:2588816-2588816
8 KCNQ1 NM_000218.3(KCNQ1):c.1043_1054delinsCA (p.Gly348fs) Indel Pathogenic 919956 11:2606452-2606463 11:2585222-2585233
9 KCNQ1-AS1 NM_181798.1(KCNQ1):c.1461_1463del (p.His487del) Deletion Pathogenic 53020 rs397508101 11:2869042-2869044 11:2847812-2847814
10 KCNQ1 NM_181798.1(KCNQ1):c.962del (p.Pro321fs) Deletion Pathogenic 52977 rs397508087 11:2610029-2610029 11:2588799-2588799
11 KCNH2 NM_172056.2(KCNH2):c.106del (p.Val36fs) Deletion Pathogenic 200807 rs794728507 7:150672000-150672000 7:150974912-150974912
12 KCNH2 NM_172056.2(KCNH2):c.100del (p.Ala34fs) Deletion Pathogenic 200805 rs794728506 7:150672006-150672006 7:150974918-150974918
13 KCNH2 NM_172056.2(KCNH2):c.2053del (p.Arg685fs) Deletion Pathogenic 200791 rs794728500 7:150648101-150648101 7:150951013-150951013
14 KCNH2 NM_172056.2(KCNH2):c.1815del (p.Ser606fs) Deletion Pathogenic 200789 rs794728499 7:150648666-150648666 7:150951578-150951578
15 KCNH2 NM_172056.2(KCNH2):c.1142del (p.Gly381fs) Deletion Pathogenic 200785 rs794728497 7:150649928-150649928 7:150952840-150952840
16 KCNH2 NM_172056.2(KCNH2):c.373_374insGTGG (p.Phe125fs) Insertion Pathogenic 200759 rs794728489 7:150656758-150656759 7:150959670-150959671
17 KCNH2 NM_172056.2(KCNH2):c.244_252dup (p.Ile82_Gln84dup) Duplication Pathogenic 200717 rs794728476 7:150671853-150671854 7:150974765-150974766
18 KCNH2 NM_000238.3(KCNH2):c.3136del (p.Gln1046fs) Deletion Pathogenic 200709 rs794728472 7:150644432-150644432 7:150947344-150947344
19 KCNH2 NM_000238.3(KCNH2):c.3079dup (p.Leu1027fs) Duplication Pathogenic 200695 rs794728465 7:150644488-150644489 7:150947400-150947401
20 KCNH2 NM_000238.3(KCNH2):c.2783_2789del (p.Gly928fs) Deletion Pathogenic 200676 rs794728457 7:150644870-150644876 7:150947782-150947788
21 KCNH2 NM_172056.2(KCNH2):c.1201_1204dup (p.His402fs) Duplication Pathogenic 200630 rs794728434 7:150649865-150649866 7:150952777-150952778
22 KCNH2 NM_172056.2(KCNH2):c.853_859del (p.Ala285fs) Deletion Pathogenic 200618 rs794728428 7:150655204-150655210 7:150958116-150958122
23 KCNH2 NM_172056.2(KCNH2):c.809_812delinsAAAAGC (p.Thr270fs) Indel Pathogenic 200614 rs794728426 7:150655251-150655254 7:150958163-150958166
24 KCNH2 NM_000238.3(KCNH2):c.3096_3099dup (p.Pro1034fs) Duplication Pathogenic 200699 rs794728467 7:150644468-150644469 7:150947380-150947381
25 KCNH2 NM_000238.3(KCNH2):c.2892del (p.Gly965fs) Deletion Pathogenic 418247 rs794728462 7:150644767-150644767 7:150947679-150947679
26 SCN5A NM_000335.5(SCN5A):c.3595dup (p.His1199fs) Duplication Pathogenic 924057 3:38616855-38616856 3:38575364-38575365
27 SCN5A NM_000335.5(SCN5A):c.127C>T (p.Arg43Ter) SNV Pathogenic 924596 3:38674672-38674672 3:38633181-38633181
28 KCNQ1 NM_000218.3(KCNQ1):c.1330del (p.Thr444fs) Deletion Pathogenic 925351 11:2610021-2610021 11:2588791-2588791
29 KCNQ1OT1 NM_000218.3(KCNQ1):c.1443_1461dup (p.Asp488fs) Duplication Pathogenic 926196 11:2683236-2683237 11:2662006-2662007
30 SCN5A NM_000335.5(SCN5A):c.189del (p.Lys63fs) Deletion Pathogenic 928434 3:38674610-38674610 3:38633119-38633119
31 KCNH2 NM_172056.2(KCNH2):c.735_754dup (p.Arg252fs) Duplication Pathogenic 200612 rs794728425 7:150655308-150655309 7:150958220-150958221
32 KCNH2 NM_000238.3(KCNH2):c.2777del (p.Pro926fs) Deletion Pathogenic 200674 rs794728456 7:150644882-150644882 7:150947794-150947794
33 KCNH2 NM_172057.2(KCNH2):c.2085_2092dup (p.Val698fs) Duplication Pathogenic 200705 rs794728470 7:150644455-150644456 7:150947367-150947368
34 KCNH2 NM_172056.2(KCNH2):c.154del (p.Cys52fs) Deletion Pathogenic 200809 rs794728508 7:150671952-150671952 7:150974864-150974864
35 TANGO2 NM_152906.7(TANGO2):c.460G>A (p.Gly154Arg) SNV Pathogenic 208823 rs752298579 22:20049061-20049061 22:20061538-20061538
36 TANGO2 NM_152906.7(TANGO2):c.146-3605_451+2245del Deletion Pathogenic 224772 22:20036383-20045781 22:20048860-20058258
37 CAPN3 NM_000070.3(CAPN3):c.1322del (p.Gly441fs) Deletion Pathogenic 281062 rs1555421871 15:42691815-42691815 15:42399617-42399617
38 PKP2 NM_004572.3(PKP2):c.14del (p.Gly5fs) Deletion Pathogenic 45027 rs397516996 12:33049652-33049652 12:32896718-32896718
39 PKP2 NM_004572.3(PKP2):c.2013del (p.Lys672fs) Deletion Pathogenic 202022 rs764817683 12:32974422-32974422 12:32821488-32821488
40 PKP2 NM_001005242.3(PKP2):c.235C>T (p.Arg79Ter) SNV Pathogenic 6754 rs121434420 12:33031955-33031955 12:32879021-32879021
41 PKP2 NM_001005242.3(PKP2):c.1211dup (p.Val406fs) Duplication Pathogenic 45015 rs397516989 12:33003866-33003867 12:32850932-32850933
42 DSP NM_004415.4(DSP):c.699G>A (p.Trp233Ter) SNV Pathogenic 44946 rs397516955 6:7562986-7562986 6:7562753-7562753
43 SCN5A NM_198056.2(SCN5A):c.1100G>A (p.Arg367His) SNV Pathogenic 9390 rs28937318 3:38648200-38648200 3:38606709-38606709
44 KCNQ1 NM_181798.1(KCNQ1):c.96+1G>A SNV Pathogenic 200874 rs762814879 11:2549249-2549249 11:2528019-2528019
45 KCNQ1 NM_181798.1(KCNQ1):c.121G>A (p.Gly41Arg) SNV Pathogenic 53052 rs179489 11:2591882-2591882 11:2570652-2570652
46 KCNH2 NM_172057.2(KCNH2):c.1765dup (p.Glu589fs) Duplication Pathogenic 200678 rs794728458 7:150644873-150644874 7:150947785-150947786
47 KCNQ1 NM_181798.1(KCNQ1):c.1385G>A (p.Gly462Asp) SNV Pathogenic 3140 rs120074190 11:2799239-2799239 11:2778009-2778009
48 KCNQ1 NM_181798.1(KCNQ1):c.188G>A (p.Arg63Gln) SNV Pathogenic 3117 rs120074178 11:2591949-2591949 11:2570719-2570719
49 SCN5A NM_000335.4(SCN5A):c.2548_2549GT[3] (p.Phe851fs) Microsatellite Pathogenic 201560 rs397514450 3:38627417-38627418 3:38585926-38585927
50 KCNQ1 NM_000218.3(KCNQ1):c.1552C>T (p.Arg518Ter) SNV Pathogenic 3131 rs17215500 11:2790111-2790111 11:2768881-2768881

Expression for Cardiac Arrhythmia

Search GEO for disease gene expression data for Cardiac Arrhythmia.

Pathways for Cardiac Arrhythmia

Pathways related to Cardiac Arrhythmia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.49 SCN5A SCN3B SCN1B RYR2 RANGRF KCNQ1
2
Show member pathways
12.23 SCN5A SCN1B RYR2 KCNQ1
3 12.06 KCNQ1 KCNH2 KCNE2 GNB5
4 11.93 SCN5A SCN3B RYR2 KCNQ1 KCNH2
5
Show member pathways
11.77 SCN5A SCN3B SCN1B ANK2
6
Show member pathways
11.31 SCN5A SCN3B SCN1B RANGRF KCNQ1 KCNE2
7 11.03 SCN5A SCN3B SCN1B ANK2
8 11.02 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2

GO Terms for Cardiac Arrhythmia

Cellular components related to Cardiac Arrhythmia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.21 SCN5A SCN3B SCN1B RYR2 RANGRF PKP2
2 sarcolemma GO:0042383 9.62 SCN5A RYR2 DTNA ANK2
3 voltage-gated potassium channel complex GO:0008076 9.58 KCNQ1 KCNH2 KCNE2
4 T-tubule GO:0030315 9.46 SCN5A SCN1B CAPN3 ANK2
5 voltage-gated sodium channel complex GO:0001518 9.43 SCN5A SCN3B SCN1B
6 Z disc GO:0030018 9.35 SCN5A SCN3B RYR2 CAPN3 ANK2
7 intercalated disc GO:0014704 9.1 SCN5A SCN1B RANGRF PKP2 DSP ANK2

Biological processes related to Cardiac Arrhythmia according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 10.15 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
2 ion transmembrane transport GO:0034220 10.04 SCN5A SCN3B SCN1B RYR2 KCNH2
3 regulation of ion transmembrane transport GO:0034765 9.93 SCN5A SCN3B SCN1B KCNQ1 KCNH2 KCNE2
4 sodium ion transport GO:0006814 9.88 SCN5A SCN3B SCN1B
5 sodium ion transmembrane transport GO:0035725 9.87 SCN5A SCN3B SCN1B
6 cellular response to drug GO:0035690 9.85 KCNQ1 KCNH2 KCNE2
7 cardiac conduction GO:0061337 9.85 SCN5A SCN3B SCN1B KCNQ1 KCNH2 KCNE2
8 regulation of heart rate GO:0002027 9.8 SCN5A RYR2 RANGRF ANK2
9 positive regulation of heart rate GO:0010460 9.79 SCN3B RYR2 KCNQ1
10 membrane depolarization GO:0051899 9.79 SCN5A SCN3B SCN1B
11 regulation of sodium ion transmembrane transporter activity GO:2000649 9.77 SCN3B SCN1B RANGRF
12 membrane depolarization during action potential GO:0086010 9.77 SCN5A SCN3B KCNH2
13 potassium ion export across plasma membrane GO:0097623 9.76 KCNQ1 KCNH2 KCNE2
14 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.75 KCNQ1 KCNH2 KCNE2
15 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.74 SCN5A SCN3B SCN1B
16 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.73 RYR2 PKP2 DSP
17 positive regulation of sodium ion transport GO:0010765 9.73 SCN5A SCN3B SCN1B PKP2
18 cardiac muscle contraction GO:0060048 9.73 SCN5A SCN3B SCN1B RYR2 KCNQ1 KCNH2
19 membrane repolarization GO:0086009 9.72 KCNQ1 KCNH2 KCNE2
20 cardiac muscle cell action potential involved in contraction GO:0086002 9.72 SCN5A SCN3B SCN1B PKP2 KCNE2
21 regulation of membrane repolarization GO:0060306 9.71 KCNQ1 KCNH2 KCNE2
22 atrial cardiac muscle cell action potential GO:0086014 9.71 SCN5A SCN3B KCNQ1 ANK2
23 regulation of cardiac muscle contraction GO:0055117 9.7 RYR2 ANK2
24 regulation of potassium ion transmembrane transport GO:1901379 9.7 KCNH2 KCNE2
25 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.7 KCNQ1 KCNE2
26 membrane repolarization during action potential GO:0086011 9.7 KCNQ1 KCNH2 KCNE2
27 positive regulation of potassium ion transmembrane transport GO:1901381 9.69 KCNQ1 KCNH2
28 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.69 RYR2 PKP2
29 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.69 SCN5A SCN3B SCN1B
30 regulation of cardiac muscle cell contraction GO:0086004 9.68 SCN5A ANK2
31 cellular response to epinephrine stimulus GO:0071872 9.68 RYR2 KCNQ1
32 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.68 KCNQ1 KCNH2
33 regulation of sodium ion transmembrane transport GO:1902305 9.67 SCN5A RANGRF
34 regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9.67 RYR2 ANK2
35 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.67 SCN5A SCN3B
36 negative regulation of voltage-gated potassium channel activity GO:1903817 9.66 KCNQ1 KCNE2
37 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.66 PKP2 DSP
38 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.65 SCN5A KCNQ1
39 desmosome organization GO:0002934 9.65 PKP2 DSP
40 membrane depolarization during SA node cell action potential GO:0086046 9.65 SCN5A ANK2
41 SA node cell action potential GO:0086015 9.65 SCN5A SCN3B ANK2
42 sarcoplasmic reticulum calcium ion transport GO:0070296 9.64 RYR2 ANK2
43 regulation of atrial cardiac muscle cell action potential GO:0098910 9.63 RYR2 ANK2
44 regulation of SA node cell action potential GO:0098907 9.63 RYR2 ANK2
45 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.63 SCN5A SCN1B KCNQ1 KCNH2 KCNE2 ANK2
46 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.62 SCN5A SCN1B
47 ventricular cardiac muscle cell action potential GO:0086005 9.56 SCN5A SCN3B RYR2 PKP2 KCNQ1 KCNH2
48 regulation of heart rate by cardiac conduction GO:0086091 9.28 SCN5A SCN3B SCN1B PKP2 KCNQ1 KCNH2

Molecular functions related to Cardiac Arrhythmia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 ion channel activity GO:0005216 9.8 SCN5A RYR2 KCNQ1 KCNH2
2 potassium channel activity GO:0005267 9.72 KCNQ1 KCNH2 KCNE2
3 voltage-gated potassium channel activity GO:0005249 9.7 KCNQ1 KCNH2 KCNE2
4 scaffold protein binding GO:0097110 9.67 SCN5A KCNQ1 KCNH2 DSP
5 sodium channel activity GO:0005272 9.63 SCN5A SCN3B SCN1B
6 delayed rectifier potassium channel activity GO:0005251 9.61 KCNQ1 KCNH2 KCNE2
7 voltage-gated sodium channel activity GO:0005248 9.58 SCN5A SCN1B
8 inward rectifier potassium channel activity GO:0005242 9.57 KCNH2 KCNE2
9 protein kinase A catalytic subunit binding GO:0034236 9.56 RYR2 KCNQ1
10 sodium channel regulator activity GO:0017080 9.56 SCN3B SCN1B RANGRF PKP2
11 sodium channel inhibitor activity GO:0019871 9.54 SCN3B SCN1B
12 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.51 KCNQ1 KCNH2
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 9.5 KCNQ1 KCNH2 KCNE2
14 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.48 PKP2 DSP
15 voltage-gated ion channel activity GO:0005244 9.43 SCN5A SCN3B SCN1B KCNQ1 KCNH2 KCNE2
16 voltage-gated sodium channel activity involved in Purkinje myocyte action potential GO:0086062 9.4 SCN5A SCN1B
17 voltage-gated sodium channel activity involved in cardiac muscle cell action potential GO:0086006 9.33 SCN5A SCN3B SCN1B
18 ion channel binding GO:0044325 9.28 SCN5A SCN3B SCN1B RYR2 RANGRF PKP2

Sources for Cardiac Arrhythmia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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