Aliases & Classifications for Cardiac Arrhythmia

MalaCards integrated aliases for Cardiac Arrhythmia:

Name: Cardiac Arrhythmia 56 29 6 17
Adverse Event Associated with Cardiac Arrhythmia 71
Premature Cardiac Complex 71
Extrasystoles 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
cardiac arrhythmia:
Clinical modifier sudden death
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 115000
ICD10 32 I49.8 I49.9
MedGen 41 C0003811
SNOMED-CT via HPO 68 263681008 26636000 88425004
UMLS 71 C0340464 C1560249

Summaries for Cardiac Arrhythmia

MalaCards based summary : Cardiac Arrhythmia, also known as adverse event associated with cardiac arrhythmia, is related to cardiac conduction defect and familial short qt syndrome, and has symptoms including pulsus trigeminus and bigeminal pulse. An important gene associated with Cardiac Arrhythmia is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Transmission across Chemical Synapses and Cardiac conduction. The drugs Diphenhydramine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are abnormality of the nervous system and polymorphic and polytopic ventricular extrasystoles

More information from OMIM: 115000

Related Diseases for Cardiac Arrhythmia

Diseases related to Cardiac Arrhythmia via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 558, show less)
# Related Disease Score Top Affiliating Genes
1 cardiac conduction defect 32.4 SCN5A RYR2 KCNQ1 KCNH2
2 familial short qt syndrome 31.6 KCNQ1 KCNJ2 KCNH2
3 arrhythmogenic right ventricular dysplasia, familial, 8 31.3 RYR2 PKP2 JUP
4 ventricular fibrillation, paroxysmal familial, 1 31.2 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 KCNE1
5 progressive familial heart block, type ia 31.2 SCN5A ANK2
6 brugada syndrome 5 31.1 TANGO2 SCN5A
7 sick sinus syndrome 31.0 SCN5A RANGRF KCNJ2 CACNA1C ANK2
8 syncope 30.7 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2
9 long qt syndrome 6 30.5 SCN5A KCNQ1 KCNJ2 KCNH2 KCNE2 KCNE1
10 brugada syndrome 3 30.4 KCNE2 CACNA1C-AS1 CACNA1C ANK2
11 brugada syndrome 4 30.4 SCN5A KCNQ1 KCNJ2 KCNH2 CACNA1C
12 sudden infant death syndrome 30.4 SCN5A RYR2 KCNQ1 KCNH2
13 brugada syndrome 1 30.2 SCN5A RYR2 KCNH2 AKAP9
14 atrial fibrillation 30.2 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
15 third-degree atrioventricular block 30.2 SCN5A KCNJ2
16 congestive heart failure 30.0 SCN5A RYR2 KCNQ1 KCNJ2 KCNE2 CACNA1C
17 long qt syndrome 12 29.9 SCN5A KCNQ1 KCNH2 KCNE2 KCNE1 ANK2
18 atrial standstill 1 29.9 SCN5A RYR2 PKP2 JUP
19 left bundle branch hemiblock 29.9 SCN5A RYR2 PKP2 JUP
20 long qt syndrome 9 29.8 SCN5A KCNQ1 KCNJ2 KCNE2 KCNE1 CACNA1C
21 wolff-parkinson-white syndrome 29.8 SCN5A KCNQ1 KCNJ2 KCNH2 KCNE2 KCNE1
22 right bundle branch block 29.8 SCN5A RANGRF PKP2 KCNH2 CACNA1C
23 hyperkalemic periodic paralysis 29.7 SCN5A KCNJ2
24 atrioventricular block 29.7 SCN5A RYR2 KCNQ1 KCNH2 KCNE2 KCNE1
25 cardiac arrest 29.7 SCN5A RYR2 KCNQ1 KCNH2 ANK2 AKAP9
26 long qt syndrome 11 29.6 KCNQ1 KCNJ2 KCNE2 KCNE1 CACNA1C ANK2
27 long qt syndrome 13 29.5 SCN5A KCNQ1 KCNJ2 KCNH2 KCNE2 KCNE1
28 familial long qt syndrome 29.3 SCN5A KCNQ1 KCNJ2 KCNH2 KCNE2 KCNE1
29 long qt syndrome 3 29.3 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
30 long qt syndrome 2 29.3 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
31 hypokalemic periodic paralysis, type 1 29.2 SCN5A KCNJ2 KCNE1 CACNA1C
32 andersen cardiodysrhythmic periodic paralysis 29.2 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
33 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 28.8 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
34 long qt syndrome 5 28.7 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
35 sinoatrial node disease 28.7 SCN5A RYR2 RANGRF KCNQ1 KCNJ2 KCNH2
36 leopard syndrome 28.7 PKP2 KCNQ1 KCNH2 JUP CACNA1C
37 long qt syndrome 1 28.4 SCN5A RYR2 RANGRF PKP2 KCNQ1 KCNJ2
38 heart disease 28.2 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
39 jervell and lange-nielsen syndrome 1 28.0 SCN5A KCNQ1 KCNJ2 KCNH2 KCNE2 KCNE1
40 short qt syndrome 27.8 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
41 arrhythmogenic right ventricular cardiomyopathy 27.4 SCN5A RYR2 PKP2 KCNH2 KCNE1 JUP
42 long qt syndrome 27.1 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
43 brugada syndrome 26.8 SCN5A RYR2 RANGRF PKP2 KCNQ1 KCNJ2
44 catecholaminergic polymorphic ventricular tachycardia 26.6 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
45 dilated cardiomyopathy 26.6 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
46 timothy syndrome 26.5 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
47 familial atrial fibrillation 26.1 SCN5A RYR2 RANGRF PKP2 KCNQ1 KCNJ2
48 metabolic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 12.8
49 intellectual developmental disorder with cardiac arrhythmia 12.8
50 language delay and attention deficit-hyperactivity disorder/cognitive impairment with or without cardiac arrhythmia 12.7
51 cardiac arrhythmia, ankyrin-b-related 12.7
52 extrasystoles, multiform ventricular, with short stature, hyperpigmentation and microcephaly 12.3
53 extrasystoles short stature hyperpigmentation microcephaly 12.2
54 muscular dystrophy, limb-girdle, autosomal recessive 25 12.1
55 ogden syndrome 11.9
56 tango2-related metabolic encephalopathy and arrhythmias 11.8
57 guillain-barre syndrome 11.4
58 long qt syndrome 8 11.4
59 myotonic dystrophy 1 11.4
60 spondylometaphyseal dysplasia, sedaghatian type 11.4
61 myotonic dystrophy 2 11.4
62 hand and foot deformity with flat facies 11.3
63 carnitine palmitoyltransferase ii deficiency, lethal neonatal 11.3
64 chronic atrial and intestinal dysrhythmia 11.3
65 thyrotoxic periodic paralysis 11.3
66 ventricular extrasystoles with syncope, perodactyly, and robin sequence 11.1
67 pseudohypoaldosteronism, type i, autosomal recessive 11.1
68 refsum disease, classic 11.1
69 heterotaxy, visceral, 1, x-linked 11.1
70 cardiomyopathy, infantile histiocytoid 11.1
71 hypomagnesemia 1, intestinal 11.1
72 ventricular fibrillation, paroxysmal familial, 2 11.1
73 glycogen storage disease xv 11.1
74 congenital heart defects, multiple types, 4 11.1
75 congenital heart defects, multiple types, 5 11.1
76 progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5 11.1
77 distal renal tubular acidosis 11.1
78 his bundle tachycardia 11.1
79 brugada syndrome 2 10.9
80 familial sick sinus syndrome 10.8
81 acute myocardial infarction 10.6
82 sleep apnea 10.6
83 hypokalemia 10.6
84 brugada syndrome 6 10.6
85 brugada syndrome 7 10.6
86 brugada syndrome 8 10.6
87 torsade de pointes, short-coupled variant 10.6
88 brugada syndrome 9 10.6
89 coronary heart disease 1 10.5
90 myocardial infarction 10.5
91 hypertrophic cardiomyopathy 10.4
92 ischemia 10.4
93 hypoglycemia 10.4
94 idiopathic ventricular fibrillation, non brugada type 10.4
95 pulmonary disease, chronic obstructive 10.4
96 kidney disease 10.4
97 orthostatic intolerance 10.4
98 second-degree atrioventricular block 10.4
99 heart valve disease 10.3
100 epilepsy 10.3
101 myocarditis 10.3
102 progressive familial heart block, type ib 10.3
103 multifocal atrial tachycardia 10.3
104 respiratory failure 10.3
105 angina pectoris 10.3
106 coronary artery anomaly 10.3
107 hyperthyroidism 10.3
108 seizure disorder 10.3
109 periodic paralysis 10.3
110 arteries, anomalies of 10.2
111 hyperlipoproteinemia, type iii 10.2
112 visual epilepsy 10.2
113 autonomic dysfunction 10.2
114 ventricular tachycardia, catecholaminergic polymorphic, 3 10.2 RYR2 KCNJ2
115 atrioventricular dissociation 10.2
116 hypothyroidism 10.2
117 heart septal defect 10.2
118 cerebrovascular disease 10.2
119 end stage renal failure 10.2
120 lung disease 10.2
121 apnea, obstructive sleep 10.2
122 graves disease 1 10.2
123 pulmonary hypertension 10.2
124 atrial heart septal defect 10.2
125 myotonic dystrophy 10.2
126 stroke, ischemic 10.1
127 resting heart rate, variation in 10.1
128 hypertensive heart disease 10.1
129 diarrhea 10.1
130 liver disease 10.1
131 muscular dystrophy 10.1
132 47,xyy 10.1
133 48,xyyy 10.1
134 hypoxia 10.1
135 arrhythmogenic right ventricular dysplasia, familial, 3 10.1 RYR2 PKP2
136 migraine with or without aura 1 10.1
137 pheochromocytoma 10.1
138 sarcoidosis 1 10.1
139 scleroderma, familial progressive 10.1
140 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
141 branchiootic syndrome 1 10.1
142 anxiety 10.1
143 rheumatic heart disease 10.1
144 adrenal gland pheochromocytoma 10.1
145 non-alcoholic fatty liver disease 10.1
146 hemopericardium 10.1
147 pericardial effusion 10.1
148 chagas disease 10.1
149 tuberous sclerosis 10.1
150 chronic kidney disease 10.1
151 intracranial hypertension 10.1
152 fatty liver disease 10.1
153 aneurysm 10.1
154 alcohol dependence 10.1
155 autoimmune disease 10.1
156 fibrosis of extraocular muscles, congenital, 1 10.1
157 hypertension, essential 10.1
158 hydrops fetalis, nonimmune 10.1
159 asthma 10.1
160 early repolarization associated with ventricular fibrillation 10.1
161 spastic paraplegia, intellectual disability, nystagmus, and obesity 10.1
162 metabolic acidosis 10.1
163 coronary artery vasospasm 10.1
164 pericarditis 10.1
165 glomerulonephritis 10.1
166 acute kidney failure 10.1
167 myopathy 10.1
168 dystonia 10.1
169 intermediate coronary syndrome 10.1
170 traumatic brain injury 10.1
171 pierre robin syndrome 10.1
172 pyelonephritis 10.1
173 isolated pierre robin sequence 10.1
174 anhidrosis, isolated, with normal sweat glands 10.0 RYR2 CACNA1C
175 long qt syndrome 14 10.0 KCNE1 ANK2
176 pulmonary hypertension, primary, 1 10.0
177 supravalvular aortic stenosis 10.0
178 volvulus of midgut 10.0
179 hemochromatosis, type 1 10.0
180 rett syndrome 10.0
181 aging 10.0
182 anorexia nervosa 10.0
183 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
184 hydrops, lactic acidosis, and sideroblastic anemia 10.0
185 hypophosphatemia 10.0
186 first-degree atrioventricular block 10.0
187 peripheral artery disease 10.0
188 dextro-looped transposition of the great arteries 10.0
189 endocarditis 10.0
190 cardiac tamponade 10.0
191 mitral valve insufficiency 10.0
192 autonomic neuropathy 10.0
193 hemosiderosis 10.0
194 polyneuropathy 10.0
195 alcohol use disorder 10.0
196 bronchiolitis 10.0
197 lipid metabolism disorder 10.0
198 central nervous system disease 10.0
199 bronchitis 10.0
200 nervous system disease 10.0
201 subacute delirium 10.0
202 central sleep apnea 10.0
203 meningitis 10.0
204 systolic heart failure 10.0
205 brain injury 10.0
206 head injury 10.0
207 rare hereditary hemochromatosis 10.0
208 familial periodic paralysis 10.0 SCN5A KCNJ2 CACNA1C
209 naxos disease 9.9 PKP2 JUP
210 arrhythmogenic right ventricular dysplasia, familial, 13 9.9 RYR2 PKP2
211 spondyloarthropathy 1 9.9
212 huntington disease 9.9
213 tetralogy of fallot 9.9
214 acrocallosal syndrome 9.9
215 cystic fibrosis 9.9
216 glycogen storage disease ii 9.9
217 heart block, congenital 9.9
218 body mass index quantitative trait locus 11 9.9
219 fabry disease 9.9
220 body mass index quantitative trait locus 9 9.9
221 body mass index quantitative trait locus 8 9.9
222 body mass index quantitative trait locus 4 9.9
223 body mass index quantitative trait locus 10 9.9
224 body mass index quantitative trait locus 7 9.9
225 syndactyly, mesoaxial synostotic, with phalangeal reduction 9.9
226 body mass index quantitative trait locus 12 9.9
227 body mass index quantitative trait locus 14 9.9
228 muscle hypertrophy 9.9
229 body mass index quantitative trait locus 18 9.9
230 leukemia, acute lymphoblastic 3 9.9
231 carbonic anhydrase va deficiency, hyperammonemia due to 9.9
232 body mass index quantitative trait locus 19 9.9
233 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.9
234 body mass index quantitative trait locus 20 9.9
235 peripheral vascular disease 9.9
236 diffuse large b-cell lymphoma 9.9
237 infective endocarditis 9.9
238 inguinal hernia 9.9
239 hemiplegia 9.9
240 anhidrosis 9.9
241 inflammatory spondylopathy 9.9
242 goiter 9.9
243 pyloric stenosis 9.9
244 dementia 9.9
245 patent foramen ovale 9.9
246 toxic shock syndrome 9.9
247 glossopharyngeal neuralgia 9.9
248 ventricular septal defect 9.9
249 mitral valve stenosis 9.9
250 vascular disease 9.9
251 opiate dependence 9.9
252 idiopathic interstitial pneumonia 9.9
253 testicular cancer 9.9
254 gastric dilatation 9.9
255 pulmonary fibrosis 9.9
256 acute myocarditis 9.9
257 hyperglycemia 9.9
258 coronary stenosis 9.9
259 aortic valve insufficiency 9.9
260 panic disorder 9.9
261 mitral valve disease 9.9
262 spondylitis 9.9
263 b-cell lymphoma 9.9
264 vascular dementia 9.9
265 amyloidosis 9.9
266 diabetes mellitus 9.9
267 status asthmaticus 9.9
268 pulmonary embolism 9.9
269 drug dependence 9.9
270 binswanger's disease 9.9
271 paroxysmal ventricular fibrillation 9.9
272 pulmonary vein stenosis 9.9
273 pure autonomic failure 9.9
274 single ventricular heart 9.9
275 depression 9.9
276 anoxia 9.9
277 encephalopathy 9.9
278 headache 9.9
279 spinal cord injury 9.9
280 atrial standstill 9.9
281 rapidly involuting congenital hemangioma 9.9
282 digitalis poisoning 9.9
283 pik3ca-related overgrowth syndrome 9.9
284 cardiogenic shock 9.9
285 atrial septal aneurysm 9.9
286 cleft palate, isolated 9.9
287 marfan syndrome 9.9
288 dowling-degos disease 1 9.9
289 neural tube defects 9.9
290 transposition of the great arteries, dextro-looped 1 9.9
291 mental retardation, autosomal dominant 44 9.9
292 brachydactyly 9.9
293 isolated growth hormone deficiency 9.9
294 microcephaly 9.9
295 depersonalization disorder 9.9
296 cholecystolithiasis 9.9
297 choledocholithiasis 9.9
298 hepatitis c 9.9
299 collagen disease 9.9
300 lupus erythematosus 9.9
301 heterotaxy 9.9
302 broken heart syndrome 9.9
303 dwarfism 9.9
304 polymyositis 9.9
305 fainting 9.9
306 interatrial communication 9.9
307 univentricular heart 9.9
308 malignant hyperthermia 9.9 SCN5A RYR2 CACNA1C
309 arrhythmogenic right ventricular dysplasia, familial, 1 9.8 RYR2 PKP2 JUP
310 arrhythmogenic right ventricular dysplasia, familial, 6 9.8 RYR2 PKP2 JUP
311 arrhythmogenic right ventricular dysplasia, familial, 4 9.8 RYR2 PKP2 JUP
312 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 9.8 RYR2 PKP2 JUP
313 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 9.8 RYR2 PKP2 JUP
314 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 9.8 RYR2 PKP2 JUP
315 arrhythmogenic right ventricular dysplasia, familial, 11 9.8 RYR2 PKP2 JUP
316 arrhythmogenic right ventricular dysplasia, familial, 10 9.8 RYR2 PKP2 JUP
317 arrhythmogenic right ventricular dysplasia, familial, 5 9.8 RYR2 PKP2 JUP
318 cardiomyopathy, dilated, with woolly hair and keratoderma 9.8 RYR2 PKP2 JUP
319 arrhythmogenic right ventricular dysplasia, familial, 2 9.8 RYR2 PKP2 JUP
320 atherosclerosis susceptibility 9.8
321 gastroesophageal reflux 9.8
322 hepatocellular carcinoma 9.8
323 hypercalcemia, infantile, 1 9.8
324 hypercholesterolemia, familial, 1 9.8
325 hypertelorism 9.8
326 multiple system atrophy 1 9.8
327 leukemia, chronic lymphocytic 9.8
328 lipomatosis, multiple 9.8
329 myositis 9.8
330 nevus, epidermal 9.8
331 sick sinus syndrome 2 9.8
332 oculodentodigital dysplasia 9.8
333 parkinson disease, late-onset 9.8
334 pectus excavatum 9.8
335 normokalemic periodic paralysis 9.8
336 platelet aggregation, spontaneous 9.8
337 schistosoma mansoni infection, susceptibility/ 9.8
338 spondyloepimetaphyseal dysplasia, strudwick type 9.8
339 chromosome 2q35 duplication syndrome 9.8
340 cardiomyopathy, familial hypertrophic, 1 9.8
341 right atrial isomerism 9.8
342 central hypoventilation syndrome, congenital 9.8
343 lung cancer 9.8
344 lymphoma, hodgkin, classic 9.8
345 netherton syndrome 9.8
346 neuraminidase deficiency 9.8
347 ocular motor apraxia 9.8
348 asplenia, isolated congenital 9.8
349 danon disease 9.8
350 arts syndrome 9.8
351 leber optic atrophy 9.8
352 linear skin defects with multiple congenital anomalies 1 9.8
353 emery-dreifuss muscular dystrophy 1, x-linked 9.8
354 simpson-golabi-behmel syndrome, type 1 9.8
355 ataxia and polyneuropathy, adult-onset 9.8
356 epilepsy, idiopathic generalized 9.8
357 homocysteinemia 9.8
358 sickle cell anemia 9.8
359 lymphoma, non-hodgkin, familial 9.8
360 tricuspid atresia 9.8
361 hypertension, early-onset, autosomal dominant, with severe exacerbation in pregnancy 9.8
362 leukemia, chronic myeloid 9.8
363 sick sinus syndrome 1 9.8
364 severe cutaneous adverse reaction 9.8
365 lipodystrophy, congenital generalized, type 1 9.8
366 malaria 9.8
367 kawasaki disease 9.8
368 ventricular tachycardia, catecholaminergic polymorphic, 2 9.8
369 diabetes mellitus, ketosis-prone 9.8
370 acute promyelocytic leukemia 9.8
371 microvascular complications of diabetes 3 9.8
372 microvascular complications of diabetes 4 9.8
373 microvascular complications of diabetes 6 9.8
374 microvascular complications of diabetes 7 9.8
375 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 9.8
376 muscular dystrophy, congenital, lmna-related 9.8
377 fatty liver disease, nonalcoholic 1 9.8
378 lipodystrophy, congenital generalized, type 4 9.8
379 cyanosis, transient neonatal 9.8
380 beta-thalassemia 9.8
381 epileptic encephalopathy, early infantile, 13 9.8
382 leptin deficiency or dysfunction 9.8
383 ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness 9.8
384 atrial fibrillation, familial, 15 9.8
385 helix syndrome 9.8
386 deficiency anemia 9.8
387 aspiration pneumonia 9.8
388 erythema multiforme 9.8
389 epidemic typhus 9.8
390 exanthem 9.8
391 congenital generalized lipodystrophy 9.8
392 early infantile epileptic encephalopathy 9.8
393 withdrawal disorder 9.8
394 thrombosis 9.8
395 meningococcal meningitis 9.8
396 myofibrillar myopathy 9.8
397 benign teratoma 9.8
398 migraine with aura 9.8
399 pleomorphic lipoma 9.8
400 aortic atherosclerosis 9.8
401 thalassemia 9.8
402 siderosis 9.8
403 lymphocytic leukemia 9.8
404 charcot-marie-tooth disease 9.8
405 thrombotic thrombocytopenic purpura 9.8
406 tooth disease 9.8
407 amnestic disorder 9.8
408 spastic hemiplegia 9.8
409 spotted fever 9.8
410 rabies 9.8
411 plummer's disease 9.8
412 mobitz type ii atrioventricular block 9.8
413 pulmonary edema 9.8
414 constrictive pericarditis 9.8
415 bronchial disease 9.8
416 hepatorenal syndrome 9.8
417 allergic hypersensitivity disease 9.8
418 low compliance bladder 9.8
419 oligohydramnios 9.8
420 alcoholic hepatitis 9.8
421 graves' disease 9.8
422 bronchopneumonia 9.8
423 complex partial epilepsy 9.8
424 hypertrophic pyloric stenosis 9.8
425 leiomyoma 9.8
426 diabetic polyneuropathy 9.8
427 thyroid crisis 9.8
428 plasmodium vivax malaria 9.8
429 transient global amnesia 9.8
430 periventricular leukomalacia 9.8
431 nodular goiter 9.8
432 cardiac sarcoidosis 9.8
433 hairy tongue 9.8
434 hyperparathyroidism 9.8
435 schistosomiasis 9.8
436 root caries 9.8
437 neuronal ceroid lipofuscinosis 9.8
438 lymphangioma 9.8
439 panniculitis 9.8
440 rheumatic disease 9.8
441 thrombocytopenia 9.8
442 keratosis 9.8
443 pneumothorax 9.8
444 richter's syndrome 9.8
445 status epilepticus 9.8
446 impotence 9.8
447 viral hepatitis 9.8
448 optic nerve disease 9.8
449 hyperuricemia 9.8
450 cholecystitis 9.8
451 rectum adenocarcinoma 9.8
452 hyperinsulinism 9.8
453 constipation 9.8
454 dental caries 9.8
455 focal epilepsy 9.8
456 hepatitis 9.8
457 transient cerebral ischemia 9.8
458 keratopathy 9.8
459 leptospirosis 9.8
460 acromegaly 9.8
461 hemangioma 9.8
462 benign mesothelioma 9.8
463 cystic teratoma 9.8
464 bilirubin metabolic disorder 9.8
465 glycogen storage disease 9.8
466 bronchiolitis obliterans 9.8
467 pulmonary tuberculosis 9.8
468 substance abuse 9.8
469 complex regional pain syndrome 9.8
470 purpura 9.8
471 temporal lobe epilepsy 9.8
472 glycoproteinosis 9.8
473 palmoplantar keratosis 9.8
474 unverricht-lundborg syndrome 9.8
475 aortic aneurysm 9.8
476 craniopharyngioma 9.8
477 lung squamous cell carcinoma 9.8
478 systemic scleroderma 9.8
479 intracranial embolism 9.8
480 bartter disease 9.8
481 neurotic disorder 9.8
482 sleep disorder 9.8
483 mature teratoma 9.8
484 subvalvular aortic stenosis 9.8
485 adenosine deaminase deficiency 9.8
486 hemolytic anemia 9.8
487 inferior myocardial infarction 9.8
488 agoraphobia 9.8
489 plasma cell neoplasm 9.8
490 peptic ulcer disease 9.8
491 placenta disease 9.8
492 carotid artery occlusion 9.8
493 interstitial myocarditis 9.8
494 periodontitis 9.8
495 polyhydramnios 9.8
496 measles 9.8
497 duodenitis 9.8
498 neuropathy 9.8
499 achalasia 9.8
500 pemphigus 9.8
501 homocystinuria 9.8
502 priapism 9.8
503 scotoma 9.8
504 bronchiectasis 9.8
505 babesiosis 9.8
506 toxic myocarditis 9.8
507 heart aneurysm 9.8
508 diastolic heart failure 9.8
509 alopecia 9.8
510 hypoplastic left heart syndrome 9.8
511 limb-girdle muscular dystrophy 9.8
512 berardinelli-seip congenital lipodystrophy 9.8
513 depdc5-related epilepsy 9.8
514 kcnq2-related disorders 9.8
515 kcnq3-related disorders 9.8
516 mitochondrial disorders 9.8
517 scn8a-related epilepsy with encephalopathy 9.8
518 trichorhinophalangeal syndrome 9.8
519 alopecia totalis 9.8
520 bidirectional tachycardia 9.8
521 bronchogenic cyst 9.8
522 chaotic atrial tachycardia 9.8
523 chromosomal triplication 9.8
524 chronic thromboembolic pulmonary hypertension 9.8
525 growth hormone deficiency 9.8
526 heart tumor 9.8
527 mitral valve prolapse, familial, x-linked 9.8
528 pemphigus foliaceus 9.8
529 simpson-golabi-behmel syndrome 9.8
530 cerebral atrophy 9.8
531 cerebral hypoxia 9.8
532 chronic pain 9.8
533 dysautonomia 9.8
534 dysphagia 9.8
535 febrile seizures 9.8
536 hypertonia 9.8
537 myoclonus 9.8
538 tremor 9.8
539 systemic autoimmune disease 9.8
540 rare lymphatic malformation 9.8
541 congenital hemangioma 9.8
542 erythema multiforme major 9.8
543 benign idiopathic neonatal seizures 9.8
544 cirrhotic cardiomyopathy 9.8
545 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.8
546 rare disease in surgical orthopedic 9.8
547 rare surgical neurologic disease 9.8
548 overgrowth syndrome 9.8
549 hereditary optic neuropathy 9.8
550 arrhythmogenic right ventricular dysplasia, familial, 9 9.7 RYR2 PKP2 JUP
551 arrhythmogenic right ventricular dysplasia, familial, 12 9.7 RYR2 PKP2 KCNH2 JUP
552 restrictive cardiomyopathy 9.3 CACNA1C-AS1 CACNA1C AKAP9
553 long qt syndrome 10 9.3 SCN5A KCNQ1 KCNH2 KCNE2 ANK2 AKAP9
554 myasthenic syndrome, congenital, 5 8.8 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
555 congenital myasthenic syndrome 8.8 SCN5A RYR2 KCNQ1 KCNJ2 KCNH2 KCNE2
556 left ventricular noncompaction 8.6 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
557 heart conduction disease 8.3 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2
558 intrinsic cardiomyopathy 7.3 SCN5A RYR2 PKP2 KCNQ1 KCNJ2 KCNH2

Comorbidity relations with Cardiac Arrhythmia via Phenotypic Disease Network (PDN): (showing 7, show less)


Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Mitral Valve Disease
Sinoatrial Node Disease

Graphical network of the top 20 diseases related to Cardiac Arrhythmia:



Diseases related to Cardiac Arrhythmia

Symptoms & Phenotypes for Cardiac Arrhythmia

Human phenotypes related to Cardiac Arrhythmia:

31 (showing 2, show less)
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707
2 polymorphic and polytopic ventricular extrasystoles 31 HP:0006696

Symptoms via clinical synopsis from OMIM:

56
Cardiac:
arrhythmia
polymorphic and polytopic ventricular extrasystoles

Neuro:
syncopal attacks

Misc:
sudden death

Clinical features from OMIM:

115000

UMLS symptoms related to Cardiac Arrhythmia:


pulsus trigeminus, bigeminal pulse

MGI Mouse Phenotypes related to Cardiac Arrhythmia:

45 (showing 2, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 CACNA1C GNB5 JUP KCNH2 KCNJ2 KCNQ1
2 muscle MP:0005369 9.28 CACNA1C GNB5 JUP KCNH2 KCNJ2 KCNQ1

Drugs & Therapeutics for Cardiac Arrhythmia

Drugs for Cardiac Arrhythmia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 301, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
2
Histamine Approved, Investigational Phase 4 51-45-6 774
3
Promethazine Approved, Investigational Phase 4 60-87-7 4927
4
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
5
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
6
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
7
Racepinephrine Approved Phase 4 329-65-7 838
8
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
9
leucovorin Approved Phase 4 58-05-9 6006 143
10
Ibutilide Approved Phase 4 122647-31-8, 122647-32-9 60753
11
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
12
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
14
Methadone Approved Phase 4 76-99-3 4095
15
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
16
Morphine Approved, Investigational Phase 4 57-27-2 5288826
17
Adenosine Approved, Investigational Phase 4 58-61-7 60961
18
Terlipressin Approved, Investigational Phase 4 14636-12-5 72081
19
Bisoprolol Approved Phase 4 66722-44-9 2405
20
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
21
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
22
Metformin Approved Phase 4 657-24-9 14219 4091
23
Insulin glargine Approved Phase 4 160337-95-1
24
Glucagon Approved Phase 4 16941-32-5
25
Insulin lispro Approved Phase 4 133107-64-9
26
Insulin aspart Approved Phase 4 116094-23-6 16132418
27
Zinc Approved, Investigational Phase 4 7440-66-6 32051
28
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
29
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
30
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
31
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
32
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
33
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
34
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
35
nivolumab Approved Phase 4 946414-94-4
36
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
37
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
38
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
39
Cysteine Approved, Nutraceutical Phase 4 52-90-4 5862
40 Tocotrienol Investigational Phase 4 6829-55-6
41 Antiemetics Phase 4
42 Dermatologic Agents Phase 4
43 Antipruritics Phase 4
44 Histamine H1 Antagonists Phase 4
45 Histamine Antagonists Phase 4
46
Histamine Phosphate Phase 4 51-74-1 65513
47 Anti-Allergic Agents Phase 4
48 Antipsychotic Agents Phase 4
49 Dopamine Agents Phase 4
50 Dopamine D2 Receptor Antagonists Phase 4
51 Serotonin 5-HT1 Receptor Agonists Phase 4
52 Dopamine Antagonists Phase 4
53 Dopamine agonists Phase 4
54 Serotonin 5-HT2 Receptor Antagonists Phase 4
55 Serotonin Antagonists Phase 4
56 Quetiapine Fumarate Phase 4 111974-72-2
57 Epinephryl borate Phase 4
58 Neurotransmitter Agents Phase 4
59 Vasoconstrictor Agents Phase 4
60 Adrenergic Agonists Phase 4
61 Adrenergic Agents Phase 4
62 Mydriatics Phase 4
63 Vitamins Phase 4
64 Adrenergic alpha-2 Receptor Agonists Phase 4
65 Adjuvants, Anesthesia Phase 4
66 Anesthetics, General Phase 4
67 Anesthetics, Intravenous Phase 4
68 Hawthorn Phase 4
69 Vitamin B Complex Phase 4
70 Vitamin B9 Phase 4
71 Antioxidants Phase 4
72 Tocopherols Phase 4
73 Tocotrienols Phase 4
74 Folate Phase 4
75 Omega 3 Fatty Acid Phase 4
76 Hormones Phase 4
77 Free Radical Scavengers Phase 4
78 Antiviral Agents Phase 4
79 N-monoacetylcystine Phase 4
80 Antidotes Phase 4
81 Expectorants Phase 4
82 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
83 Antitussive Agents Phase 4
84 Antihypertensive Agents Phase 4
85 Hormone Antagonists Phase 4
86 Hypoglycemic Agents Phase 4
87 Insulin, Globin Zinc Phase 4
88 insulin Phase 4
89 Hydrocortisone hemisuccinate Phase 4
90 Hydrocortisone-17-butyrate Phase 4
91 Hydrocortisone 17-butyrate 21-propionate Phase 4
92 Anti-Obesity Agents Phase 4
93 Incretins Phase 4
94 Glucagon-Like Peptide 1 Phase 4
95 Tocolytic Agents Phase 4
96 Anticonvulsants Phase 4
97 Sympatholytics Phase 4
98 Cholinergic Agents Phase 4
99 Neuromuscular Agents Phase 4
100 Neuromuscular Blocking Agents Phase 4
101 Neuromuscular Nondepolarizing Agents Phase 4
102 Cholinesterase Inhibitors Phase 4
103 Analgesics, Non-Narcotic Phase 4
104 Analgesics Phase 4
105 Anti-Inflammatory Agents Phase 4
106 Fibrinolytic Agents Phase 4
107 Platelet Aggregation Inhibitors Phase 4
108 Anti-Inflammatory Agents, Non-Steroidal Phase 4
109 Antipyretics Phase 4
110 Cyclooxygenase Inhibitors Phase 4
111 Antineoplastic Agents, Immunological Phase 4
112 Anesthetics, Local Phase 4
113 Central Nervous System Depressants Phase 4
114 HIV Protease Inhibitors Phase 4
115
protease inhibitors Phase 4
116 Antithrombins Phase 4
117 Serine Proteinase Inhibitors Phase 4
118 Antithrombin III Phase 4
119 Coagulants Phase 4
120
Serine Investigational, Nutraceutical Phase 4 56-45-1 5951
121
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
122
Dexmedetomidine Approved, Vet_approved Phase 3 113775-47-6 68602 5311068
123
Imipramine Approved Phase 3 50-49-7 3696
124
Perindopril Approved Phase 3 107133-36-8, 82834-16-0 107807
125
Digoxin Approved Phase 3 20830-75-5 30322 2724385
126
Mexiletine Approved, Investigational Phase 3 31828-71-4 4178
127
Procainamide Approved Phase 3 51-06-9 4913
128
Quinidine Approved, Investigational Phase 3 56-54-2 441074
129
Verapamil Approved Phase 3 52-53-9 2520
130
Disopyramide Approved Phase 3 3737-09-5 3114
131
Colchicine Approved Phase 3 64-86-8 6167 2833
132
Ethanol Approved Phase 3 64-17-5 702