Aliases & Classifications for Cardiac Rupture

MalaCards integrated aliases for Cardiac Rupture:

Name: Cardiac Rupture 53 55
Myocardial Rupture 73

Classifications:



External Ids:

UMLS 73 C0018813

Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and pericardial effusion. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cell adhesion_ECM remodeling. The drugs Abciximab and Reteplase have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and lung, and related phenotypes are cardiovascular system and muscle

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.7 CHKB CRP PLAT
2 pericardial effusion 29.6 CHKB CRP
3 coronary artery anomaly 29.4 CHKB CRP PLAT
4 cardiogenic shock 10.7 CRP PLAT
5 dressler's syndrome 10.7 CRP PLAT
6 ligneous conjunctivitis 10.7 ELANE PLAT
7 rapidly progressive glomerulonephritis 10.7 CRP ELANE
8 intermediate coronary syndrome 10.7 CRP PLAT
9 dirofilariasis 10.6 CRP PLAT
10 venous insufficiency 10.6 CRP PLAT
11 slow-channel congenital myasthenic syndrome 10.6 CRP CXCL8
12 pyuria 10.6 CRP CXCL8
13 louse-borne relapsing fever 10.6 CRP CXCL8
14 felty syndrome 10.6 CXCL8 ELANE
15 myocardial infarction 10.6
16 cyclic neutropenia 10.6 CXCL8 ELANE
17 capillary leak syndrome 10.6 CXCL8 ELANE
18 lung abscess 10.6 CRP FLNC
19 status asthmaticus 10.5 CXCL8 ELANE
20 pharyngitis 10.5 CRP CXCL8
21 septic arthritis 10.5 CRP CXCL8
22 periodontosis 10.5 CXCL8 ELANE
23 acute cystitis 10.5 CRP CXCL8
24 pulmonary aspergilloma 10.5 CRP FLNC
25 acute pyelonephritis 10.5 CRP CXCL8
26 wells syndrome 10.5 CRP CXCL8
27 lipid pneumonia 10.5 CRP FLNC
28 perinatal necrotizing enterocolitis 10.5 CRP CXCL8
29 viral meningitis 10.5 CRP CXCL8
30 pleurisy 10.5 CRP CXCL8
31 alpha-1-antitrypsin deficiency 10.4 CXCL8 ELANE
32 uterine anomalies 10.4 CRP CXCL8
33 bronchopulmonary dysplasia 10.4 CXCL8 ELANE
34 leptospirosis 10.4 CRP CXCL8
35 acute respiratory distress syndrome 10.4 CXCL8 ELANE
36 brucellosis 10.3 CRP CXCL8
37 leukocyte disease 10.3 CRP ELANE
38 pyelonephritis 10.3 CRP CXCL8
39 invasive aspergillosis 10.3 CXCL8 FLNC
40 appendicitis 10.3 CRP CXCL8
41 endocarditis 10.3 CRP CXCL8 PLAT
42 gingivitis 10.2 CXCL8 ELANE PLAT
43 chorioamnionitis 10.2 CRP CXCL8 ELANE
44 autoinflammation, lipodystrophy, and dermatosis syndrome 10.2 CRP CXCL8 ELANE
45 acute pancreatitis 10.2 CRP CXCL8 ELANE
46 respiratory failure 10.2 CRP CXCL8 ELANE
47 wegener granulomatosis 10.2 CRP CXCL8 ELANE
48 periodontal disease 10.2 CRP CXCL8 ELANE
49 pneumonia 10.2 CRP CXCL8 ELANE
50 pulmonary disease, chronic obstructive 10.2 CRP CXCL8 ELANE

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP FHL2 FLNC PLAT PMM2 PRF1
2 muscle MP:0005369 9.02 CHKB FLNC PLAT PMM2 TRIM54

Drugs & Therapeutics for Cardiac Rupture

Drugs for Cardiac Rupture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 3 143653-53-6
2
Reteplase Approved, Investigational Phase 3 133652-38-7 65820
3
Exenatide Approved, Investigational Phase 3 141758-74-9 15991534
4
Apixaban Approved Phase 3 503612-47-3 10182969
5
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
6 Fibrinolytic Agents Phase 3
7 Tissue Plasminogen Activator Phase 3
8 Immunoglobulin Fab Fragments Phase 3
9 Antibodies Phase 3
10 Immunoglobulins Phase 3
11 Antibodies, Monoclonal Phase 3
12 Plasminogen Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Anticoagulants Phase 3
15 glucagon Phase 3
16 Glucagon-Like Peptide 1 Phase 3
17 Hormone Antagonists Phase 3
18 Hormones Phase 3
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
20 Hypoglycemic Agents Phase 3
21 Incretins Phase 3
22
protease inhibitors Phase 3
23 Serine Proteinase Inhibitors Phase 3
24 HIV Protease Inhibitors Phase 3
25 Factor Xa Inhibitors Phase 3
26 Antithrombin III Phase 3
27 Antithrombins Phase 3
28
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
29 Adjuvants, Immunologic Phase 1, Phase 2
30 Pharmaceutical Solutions Phase 2,Not Applicable
31
Alginic acid Approved, Investigational Not Applicable 9005-32-7
32 Coagulants Not Applicable
33 Hemostatics Not Applicable
34 Protective Agents Not Applicable
35 Radiation-Protective Agents Not Applicable
36 Calcium, Dietary Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) Completed NCT00046228 Phase 3 abciximab placebo; reteplase placebo, abciximab, abciximab;Abciximab; reteplase; abciximab placebo; abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;abciximab placebo; reteplase placebo, abciximab, abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;Abciximab; reteplase; abciximab placebo; abciximab
2 COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial Recruiting NCT02404376 Phase 3 Exenatide;Placebo
3 Phase III Acute Coronary Syndrome Terminated NCT00831441 Phase 3 Apixaban;Placebo
4 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
5 A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction Completed NCT00215124 Phase 1, Phase 2 Filgrastim
6 The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation Completed NCT01442129 Phase 2
7 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
8 Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy Unknown status NCT02843464 Not Applicable
9 Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy Unknown status NCT03018873 Not Applicable
10 Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction Completed NCT02484326
11 IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Completed NCT01226563 Not Applicable
12 Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study) Recruiting NCT03152240
13 Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect Recruiting NCT02097758 Not Applicable

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

41
Heart, Testes, Lung, Liver, Brain

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 344)
# Title Authors Year
1
Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction. ( 29364896 )
2018
2
Association of the SYNTAX Score II with cardiac rupture in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. ( 29028739 )
2018
3
Cardiac rupture during acute myocardial infarction diagnosed clinically. ( 29394186 )
2018
4
Cardiac rupture caused by traffic accident: Case reports and a literature review. ( 29457746 )
2018
5
Cardiac Rupture in a Young Male Cocaine User. ( 29326020 )
2018
6
Delayed Cardiac Rupture Induced by Traumatic Myocardial Infarction: Consequence of a 45-Magnum Blast Injury; A Comprehensive Case Review. ( 29379803 )
2018
7
Ultrasound diagnosis of cardiac rupture caused by mechanical chest compression. ( 29922738 )
2018
8
S100A8/A9 promotes MMP-9 expression in the fibroblasts from cardiac rupture after myocardial infarction by inducing macrophages secreting TNFI+. ( 29949169 )
2018
9
Intramyocardial contrast in a STEMI patient early direct evidence of cardiac rupture. ( 28967573 )
2017
10
Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture. ( 28204966 )
2017
11
Development and validation of clinical risk score to predict the cardiac rupture in patients with STEMI. ( 28132793 )
2017
12
Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture. ( 28396614 )
2017
13
Autotransplantation for Threatened Cardiac Rupture After Left Ventricular Repair. ( 28109380 )
2017
14
Extracorporeal cardiopulmonary resuscitation for blunt cardiac rupture: A case report. ( 28801040 )
2017
15
Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice. ( 29121663 )
2017
16
Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials. ( 28109576 )
2017
17
Long-term outcome and risk prediction in patients suffering acute myocardial infarction complicated by post-infarction cardiac rupture. ( 27847155 )
2017
18
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. ( 27601324 )
2016
19
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. ( 27079251 )
2016
20
Successful surgical repair of a triple cardiac rupture using modified cohesive double patch technique. ( 27385145 )
2016
21
Late Cardiac Rupture after Amplatzer Septal Occluder Implantation. ( 28100979 )
2016
22
Cardiac rupture in takotsubo cardiomyopathy treated surgically. ( 27625696 )
2016
23
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. ( 27342873 )
2016
24
Blunt Cardiac Rupture: A Diagnostic Challenge. ( 28050441 )
2016
25
Cardiac Rupture: New Features of the Old Disease. ( 26761195 )
2016
26
Deletion of CD28 Co-stimulatory Signals Exacerbates Left Ventricular Remodeling and Increases Cardiac Rupture After Myocardial Infarction. ( 27396441 )
2016
27
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. ( 27769998 )
2016
28
Blunt Traumatic Cardiac Rupture: Single-Institution Experiences over 14 Years. ( 27965920 )
2016
29
Commonalities of cardiac rupture (left ventricular free wall or ventricular septum or papillary muscle) during acute myocardial infarction secondary to atherosclerotic coronary artery disease. ( 25456862 )
2015
30
Magnetic resonance imaging-based management of silent cardiac rupture. ( 25483899 )
2015
31
False negative pericardial Focused Assessment with Sonography for Trauma examination following cardiac rupture from blunt thoracic trauma: a case report. ( 26152189 )
2015
32
Echocardiography and Cardiac Rupture: Is Contrast Extravasation an Indication for Surgery? ( 26299914 )
2015
33
Use of intra-aortic balloon pump support for oozing-type cardiac rupture after acute myocardial infarction. ( 26145582 )
2015
34
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture. ( 26511228 )
2015
35
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. ( 25450231 )
2015
36
Cardiac rupture delayed for a week in an asymptomatic child following blunt trauma. ( 26311363 )
2015
37
Cardiac rupture from blunt chest trauma diagnosed on transesophageal echocardiography. ( 25602449 )
2015
38
Cardiac rupture with giant left ventricular pseudoaneurysm following inferior wall myocardial infarction: A rare complication. ( 26458029 )
2015
39
Olmesartan prevents cardiac rupture in mice with myocardial infarction by modulating growth differentiation factor 15 and p53. ( 24749959 )
2014
40
Triple cardiac rupture. ( 24876216 )
2014
41
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. ( 24130190 )
2014
42
Thymosin-I^4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. ( 25015963 )
2014
43
Successful emergency department thoracotomy for traumatic cardiac rupture: effective utilization of a fret sternum saw. ( 24936846 )
2014
44
Predictive factors of cardiac rupture in patients with ST-elevation myocardial infarction. ( 25471834 )
2014
45
Trends in the clinical and pathological characteristics of cardiac rupture in patients with acute myocardial infarction over 35 years. ( 25332178 )
2014
46
Decreased myocardial dendritic cells is associated with impaired reparative fibrosis and development of cardiac rupture after myocardial infarction in Humans. ( 24895162 )
2014
47
Cardiac rupture due to blunt chest trauma: postmortem findings in two cases. ( 24887870 )
2014
48
Complete cardiac rupture associated with closed chest cardiac massage: case report and review of the literature. ( 24749147 )
2014
49
Cardiac rupture in a patient with Takotsubo syndrome triggered by acute myocardial infarction: two messages. ( 25499367 )
2014
50
Right massive haemothorax as the presentation of blunt cardiac rupture: the pitfall of coexisting pericardial laceration. ( 24218497 )
2014

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CXCL8 ELANE PLAT
2 11.04 CXCL8 PLAT
3 10.84 ELANE PLAT
4 9.9 CRP CXCL8

GO Terms for Cardiac Rupture

Cellular components related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 FHL2 FLNC TRIM54

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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