MCID: CRD016
MIFTS: 35

Cardiac Rupture

Categories: Rare diseases

Aliases & Classifications for Cardiac Rupture

MalaCards integrated aliases for Cardiac Rupture:

Name: Cardiac Rupture 54 56
Myocardial Rupture 74

Classifications:



External Ids:

UMLS 74 C0018813

Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and pericardial effusion. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cell adhesion_ECM remodeling. The drugs Abciximab and Reteplase have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and testes, and related phenotypes are cardiovascular system and muscle

Wikipedia : 77 Myocardial rupture is a laceration of the ventricles or atria of the heart, of the interatrial or... more...

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.8 CHKB CRP PLAT
2 pericardial effusion 29.6 CHKB CRP
3 myocardial infarction 10.7
4 dressler's syndrome 10.4 CRP PLAT
5 pulmonary aspergilloma 10.3 CRP FLNC
6 intermediate coronary syndrome 10.3 CRP PLAT
7 lipid pneumonia 10.3 CRP FLNC
8 ligneous conjunctivitis 10.3 ELANE PLAT
9 angina pectoris 10.3 CRP PLAT
10 venous insufficiency 10.3 CRP PLAT
11 rapidly progressive glomerulonephritis 10.3 CRP ELANE
12 farmer's lung 10.3 ELANE FLNC
13 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
14 pyuria 10.3 CRP CXCL8
15 peptic ulcer perforation 10.3 CRP ELANE
16 louse-borne relapsing fever 10.3 CRP CXCL8
17 pyelitis 10.3 CRP CXCL8
18 viral meningitis 10.2 CRP CXCL8
19 anterolateral myocardial infarction 10.2 CHKB PLAT
20 pharyngitis 10.2 CRP CXCL8
21 septic arthritis 10.2 CRP CXCL8
22 acute cystitis 10.2 CRP CXCL8
23 acute pyelonephritis 10.2 CRP CXCL8
24 pyelonephritis 10.2 CRP CXCL8
25 wells syndrome 10.2 CRP CXCL8
26 perinatal necrotizing enterocolitis 10.2 CRP CXCL8
27 capillary leak syndrome 10.2 CXCL8 ELANE
28 status asthmaticus 10.2 CXCL8 ELANE
29 endocardium disease 10.2 CRP PRF1
30 periodontosis 10.2 CXCL8 ELANE
31 invasive aspergillosis 10.2 CXCL8 FLNC
32 cyclic neutropenia 10.2 CXCL8 ELANE
33 hemorrhagic fever with renal syndrome 10.2 CRP CXCL8
34 pleurisy 10.2 CRP CXCL8
35 leptospirosis 10.2 CRP CXCL8
36 bronchopulmonary dysplasia 10.2 CXCL8 ELANE
37 preterm premature rupture of the membranes 10.1 CRP CXCL8
38 acute respiratory distress syndrome 10.1 CXCL8 ELANE
39 newborn respiratory distress syndrome 10.1 CXCL8 ELANE
40 brucellosis 10.1 CRP CXCL8
41 vaginal disease 10.1 CXCL8 PRF1
42 vaginitis 10.1 CXCL8 PRF1
43 alpha-1-antitrypsin deficiency 10.1 CXCL8 ELANE
44 appendicitis 10.1 CRP CXCL8
45 bacteriuria 10.1 CXCL8 PRF1
46 severe acute respiratory syndrome 10.1 CRP CXCL8
47 endocarditis 10.1 CRP CXCL8 PLAT
48 disseminated intravascular coagulation 10.1 ELANE PLAT
49 obstructive jaundice 10.1 CRP CXCL8
50 bacterial vaginosis 10.1 CXCL8 PRF1

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP FHL2 FLNC PLAT PMM2 PRF1
2 muscle MP:0005369 9.02 CHKB FLNC PLAT PMM2 TRIM54

Drugs & Therapeutics for Cardiac Rupture

Drugs for Cardiac Rupture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 3 143653-53-6
2
Reteplase Approved, Investigational Phase 3 133652-38-7 65820
3
Glucagon Approved Phase 3 16941-32-5
4
Exenatide Approved, Investigational Phase 3 141758-74-9 15991534
5
Apixaban Approved Phase 3 503612-47-3 10182969
6
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
7 Plasminogen Phase 3
8 Anticoagulants Phase 3
9 Fibrinolytic Agents Phase 3
10 Tissue Plasminogen Activator Phase 3
11 Platelet Aggregation Inhibitors Phase 3
12 Hormones Phase 3,Not Applicable
13 Glucagon-Like Peptide 1 Phase 3
14 Hormone Antagonists Phase 3
15 Hypoglycemic Agents Phase 3
16 Incretins Phase 3
17 Anti-Obesity Agents Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
19 Antithrombins Phase 3
20 Antithrombin III Phase 3
21 HIV Protease Inhibitors Phase 3
22
protease inhibitors Phase 3
23 Serine Proteinase Inhibitors Phase 3
24 Factor Xa Inhibitors Phase 3
25
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
26 Immunologic Factors Phase 1, Phase 2
27 Adjuvants, Immunologic Phase 1, Phase 2
28 Pharmaceutical Solutions Phase 2,Not Applicable
29
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
30 Calcium, Dietary Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) Completed NCT00046228 Phase 3 abciximab placebo; reteplase placebo, abciximab, abciximab;Abciximab; reteplase; abciximab placebo; abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;abciximab placebo; reteplase placebo, abciximab, abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;Abciximab; reteplase; abciximab placebo; abciximab
2 COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial Active, not recruiting NCT02404376 Phase 3 Exenatide;Placebo
3 Phase III Acute Coronary Syndrome Terminated NCT00831441 Phase 3 Apixaban;Placebo
4 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
5 A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction Completed NCT00215124 Phase 1, Phase 2 Filgrastim
6 The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation Completed NCT01442129 Phase 2
7 Allogeneic Stem Cells Implantation Combined With Coronary Bypass Grafting in Patients With Ischemic Cardiomyopathy Completed NCT01753440 Phase 2
8 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
9 Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy Unknown status NCT02843464 Not Applicable
10 Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy Unknown status NCT03018873 Not Applicable
11 Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction Completed NCT02484326
12 Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study) Completed NCT03152240
13 IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Completed NCT01226563 Not Applicable
14 Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect Recruiting NCT02097758 Not Applicable
15 Mechanical Complications of Acute Myocardial Infarction Not yet recruiting NCT03848429

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

42
Heart, Lung, Testes, Liver, Brain

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 458)
# Title Authors Year
1
A risk score model for predicting cardiac rupture after acute myocardial infarction. ( 30829714 )
2019
2
IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF-κB signaling pathway in a mouse model of acute myocardial infarction. ( 30536946 )
2019
3
Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. ( 30408466 )
2019
4
Risk factors for cardiac rupture complicating myocardial infarction: a PRISMA meta-analysis and systematic review. ( 30487185 )
2019
5
Subtle sings of contained cardiac rupture following myocardial infarction. ( 30733115 )
2019
6
Ischemic posterior wall cardiac rupture: early intervention is key for success. ( 30889964 )
2019
7
Myocardial Rupture Due to Metastasis of Urothelial Carcinoma. ( 30224587 )
2019
8
Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction. ( 30275441 )
2018
9
Myocardial rupture after small acute myocardial infarction in the absence of coronary artery disease. ( 30223140 )
2018
10
Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction. ( 29364896 )
2018
11
Cardiac rupture during acute myocardial infarction diagnosed clinically. ( 29394186 )
2018
12
Intramyocardial contrast in a STEMI patient early direct evidence of cardiac rupture. ( 28967573 )
2018
13
Association of the SYNTAX Score II with cardiac rupture in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. ( 29028739 )
2018
14
Cardiac Rupture in a Young Male Cocaine User. ( 29326020 )
2018
15
Delayed Cardiac Rupture Induced by Traumatic Myocardial Infarction: Consequence of a 45-Magnum Blast Injury; A Comprehensive Case Review. ( 29379803 )
2018
16
Cardiac rupture caused by traffic accident: Case reports and a literature review. ( 29457746 )
2018
17
Ultrasound diagnosis of cardiac rupture caused by mechanical chest compression. ( 29922738 )
2018
18
S100A8/A9 promotes MMP-9 expression in the fibroblasts from cardiac rupture after myocardial infarction by inducing macrophages secreting TNFα. ( 29949169 )
2018
19
Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction. ( 30019466 )
2018
20
Severe Cardiac Rupture by Only One Blow to the Chest in a Young Boy: An Autopsy Case. ( 30462838 )
2018
21
Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials. ( 28109576 )
2017
22
Long-term outcome and risk prediction in patients suffering acute myocardial infarction complicated by post-infarction cardiac rupture. ( 27847155 )
2017
23
Autotransplantation for Threatened Cardiac Rupture After Left Ventricular Repair. ( 28109380 )
2017
24
Development and validation of clinical risk score to predict the cardiac rupture in patients with STEMI. ( 28132793 )
2017
25
Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture. ( 28204966 )
2017
26
Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture. ( 28396614 )
2017
27
Extracorporeal cardiopulmonary resuscitation for blunt cardiac rupture. ( 28801040 )
2017
28
Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice. ( 29121663 )
2017
29
Comparison of distinctive clinical and cardiac magnetic resonance features between ST elevation myocardial infarction patients with incomplete myocardial rupture and those with moderate to severe pericardial effusion. ( 28730842 )
2017
30
Successful Use of Targeted Temperature Management After Repair of Myocardial Rupture from Blunt Chest Trauma: A Case Report. ( 27875660 )
2017
31
NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. ( 28052262 )
2017
32
Confirmed early myocardial rupture in a patient with pulseless electrical activity (PEA) following late presentation of ST elevation myocardial infarction. ( 28420670 )
2017
33
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. ( 27601324 )
2016
34
Use of intra-aortic balloon pump support for oozing-type cardiac rupture after acute myocardial infarction. ( 26145582 )
2016
35
Echocardiography and Cardiac Rupture: Is Contrast Extravasation an Indication for Surgery? ( 26299914 )
2016
36
Cardiac rupture delayed for a week in an asymptomatic child following blunt trauma. ( 26311363 )
2016
37
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture. ( 26511228 )
2016
38
Cardiac Rupture: New Features of the Old Disease. ( 26761195 )
2016
39
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. ( 27079251 )
2016
40
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. ( 27342873 )
2016
41
Successful surgical repair of a triple cardiac rupture using modified cohesive double patch technique. ( 27385145 )
2016
42
Deletion of CD28 Co-stimulatory Signals Exacerbates Left Ventricular Remodeling and Increases Cardiac Rupture After Myocardial Infarction. ( 27396441 )
2016
43
Cardiac rupture in takotsubo cardiomyopathy treated surgically. ( 27625696 )
2016
44
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. ( 27769998 )
2016
45
Blunt Traumatic Cardiac Rupture: Single-Institution Experiences over 14 Years. ( 27965920 )
2016
46
Blunt Cardiac Rupture: A Diagnostic Challenge. ( 28050441 )
2016
47
Late Cardiac Rupture after Amplatzer Septal Occluder Implantation. ( 28100979 )
2016
48
Allergy to transdermal fentanyl resulting in Staphylococcus aureus sepsis and fatal endocarditis with myocardial rupture. ( 27132207 )
2016
49
Myocardial Rupture in Acute Myocardial Infarction: Mechanistic Explanation Based on the Ventricular Myocardial Band Hypothesis. ( 26696336 )
2015
50
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. ( 25450231 )
2015

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CXCL8 ELANE PLAT
2 11.04 CXCL8 PLAT
3 10.84 ELANE PLAT
4 9.9 CRP CXCL8

GO Terms for Cardiac Rupture

Cellular components related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 FHL2 FLNC TRIM54

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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