MCID: CRD016
MIFTS: 34

Cardiac Rupture

Categories: Rare diseases

Aliases & Classifications for Cardiac Rupture

MalaCards integrated aliases for Cardiac Rupture:

Name: Cardiac Rupture 20 54
Myocardial Rupture 70

Classifications:



External Ids:

UMLS 70 C0018813

Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to cardiogenic shock and anterolateral myocardial infarction. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Fluid shear stress and atherosclerosis. Affiliated tissues include heart, bone marrow and monocytes, and related phenotypes are cardiovascular system and muscle

Wikipedia : 73 Myocardial rupture is a laceration of the ventricles or atria of the heart, of the interatrial or... more...

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 386)
# Related Disease Score Top Affiliating Genes
1 cardiogenic shock 30.7 TNF PLAT
2 anterolateral myocardial infarction 30.4 PLAT CHKB
3 pericarditis 30.2 TNF CXCL8 CRP
4 compartment syndrome 29.7 TNF CRP CHKB
5 toxic shock syndrome 29.7 TNF CXCL8 CRP
6 endocarditis 29.5 TNF PLAT CXCL8 CRP
7 cerebrovascular disease 29.4 TNF PLAT MMP9 CRP
8 gastric ulcer 29.3 TNF S100A8 MMP9 CXCL8
9 lipoprotein quantitative trait locus 29.2 TNF PLAT MMP9 CXCL8 CRP CHKB
10 hypertrophic cardiomyopathy 28.9 TNF PMM2 MMP9 FLNC FHL2
11 systemic lupus erythematosus 28.4 TNF S100A9 S100A8 MMP9 ELANE CXCL8
12 acute myocardial infarction 10.7
13 myocardial infarction 10.6
14 cardiac tamponade 10.6
15 hemopericardium 10.6
16 pericardial effusion 10.4
17 ligneous conjunctivitis 10.4 PLAT ELANE
18 acute cor pulmonale 10.4 PLAT CRP
19 slow-channel congenital myasthenic syndrome 10.4 CXCL8 CRP
20 lateral ventricle meningioma 10.3 MMP9 CRP
21 suppurative periapical periodontitis 10.3 CXCL8 CRP
22 intracranial embolism 10.3 PLAT CRP
23 acute transverse myelitis 10.3 MMP9 CXCL8
24 systemic autoimmune disease 10.3 MMP9 CRP
25 internal hemorrhoid 10.3 MMP9 CRP
26 otitis externa 10.3 ELANE CRP
27 hereditary angioedema with normal c1inh 10.3 PLAT ELANE
28 croup 10.3 CXCL8 CRP
29 pyuria 10.3 CXCL8 CRP
30 ankylosing spondylitis 3 10.3 PRF1 CRP
31 central retinal artery occlusion 10.3 PLAT CRP
32 peptic ulcer perforation 10.3 S100A8 CRP
33 heart septal defect 10.3
34 mycetoma 10.3 MMP9 CXCL8
35 ventricular septal defect 10.2
36 chronic venous insufficiency 10.2 PLAT MMP9 CRP
37 venous insufficiency 10.2 PLAT MMP9 CRP
38 hereditary angioedema 10.2 PLAT ELANE CRP
39 erythema elevatum diutinum 10.2 S100A9 CXCL8
40 hellp syndrome 10.2 PLAT CXCL8 CRP
41 carotid artery disease 10.2 PLAT MMP9 CRP
42 moyamoya disease 1 10.2 PLAT MMP9 CRP
43 drug reaction with eosinophilia and systemic symptoms 10.2 TNF CRP
44 status asthmaticus 10.2 MMP9 ELANE CXCL8
45 enterocolitis 10.2 TNF CXCL8
46 brain edema 10.2 PLAT MMP9 CRP
47 atrial standstill 1 10.2
48 anterior scleritis 10.2 TNF CRP
49 idiopathic anterior uveitis 10.2 TNF CXCL8
50 rheumatoid arthritis interstitial lung disease 10.2 TNF CRP

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 CRP FHL2 FLNC MMP9 PLAT PMM2
2 muscle MP:0005369 9.17 CHKB FLNC MMP9 PLAT PMM2 TNF

Drugs & Therapeutics for Cardiac Rupture

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Development and Validation of a Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction Completed NCT02484326

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

40
Heart, Bone Marrow, Monocytes, Smooth Muscle, Myeloid, T Cells, Endothelial

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 1310)
# Title Authors PMID Year
1
Postinfarction cardiac rupture despite immediate reperfusion therapy in a patient with severe aortic valve stenosis. 61 54
16440151 2006
2
Early use of beta-blockers is associated with attenuation of serum C-reactive protein elevation and favorable short-term prognosis after acute myocardial infarction. 54 61
12589122 2003
3
[A rare case of coronary artery perforation by a PTCA guide wire complicating with postinfarction cardiac rupture after thrombolytic therapy]. 54 61
7594850 1995
4
Direct cardiac rupture associated with sternal fracture following blunt trauma: A report of two case. 61
33665322 2021
5
Cardiac Rupture-The Most Serious Complication of Takotsubo Syndrome: A Series of Five Cases and a Systematic Review. 61
33806583 2021
6
Transesophageal Echocardiographic Diagnosis of Cardiac Rupture During Extracorporeal Membrane Oxygenation-Assisted Percutaneous Coronary Intervention. 61
32682736 2021
7
The triple-layer patch technique for post-infarction ventricular septal rupture. 61
33745902 2021
8
Isolated Right Atrial Rupture From Blunt Chest Trauma in Motor Vehicle Collisions: Mechanisms of Injury and Outcomes. 61
32649316 2021
9
Cardiac lymphoma with early response to chemotherapy: A case report and review of the literature. 61
33709334 2021
10
Unusual presentations of cardiac rupture during COVID-19 pandemic. 61
33599346 2021
11
Fatal Takotsubo syndrome in critical COVID-19 related pneumonia. 61
33259936 2021
12
Myocardial rupture after percutaneous coronary intervention of an unstable RCA lesion in myocardial infarction and concomitant stroke treated with intravenous fibrinolytic agents: A case report. 61
33768816 2021
13
Myocardial Infarction Induces Cardiac Fibroblast Transformation within Injured and Noninjured Regions of the Mouse Heart. 61
33789425 2021
14
Post-myocardial infarction left ventricular septal dissecting aneurysm: a case report. 61
33638712 2021
15
Nuclear Receptor Nur77 Controls Cardiac Fibrosis through Distinct Actions on Fibroblasts and Cardiomyocytes. 61
33562500 2021
16
Successful Conservative Treatment of Cardiac Rupture Associated with Takotsubo Syndrome. 61
33551402 2021
17
Liraglutide preconditioning attenuates myocardial ischemia/ reperfusion injury via homer1 activation. 61
33535171 2021
18
Coronary artery perforation secondary to lifesaving pericardiocentesis for cardiac tamponade: a case report. 61
33509075 2021
19
Myocardial rupture and systemic lupus erythematosus: a case report. 61
33554016 2021
20
Heart Rate Reduction with Ivabradine Prevents Cardiac Rupture after Myocardial Infarction in Mice. 61
33411111 2021
21
Phosphodiesterase-5a Knock-out Suppresses Inflammation by Down-Regulating Adhesion Molecules in Cardiac Rupture Following Myocardial Infarction. 61
33496888 2021
22
Association between acute myocardial infarction-to-cardiac rupture time and in-hospital mortality risk: a retrospective analysis of multicenter registry data from the Cardiovascular Research Consortium-8 Universities (CIRC-8U). 61
33452916 2021
23
[Surgical treatment of rupture of the anterior wall of the left ventricle in the apical region with the formation of a false aneurysm in the acute stage of myocardial infarction]. 61
33487161 2020
24
Traumatic right atrial rupture bridge to definitive repair with extra-corporeal life support. 61
33299923 2020
25
Severe aortic regurgitation following blunt chest trauma due to home accident. 61
33153276 2020
26
The effects of multimedia education on postoperative delirium in patients undergoing coronary artery bypass graft: A randomized clinical trial. 61
31532055 2020
27
Legumain is a predictor of all-cause mortality and potential therapeutic target in acute myocardial infarction. 61
33243972 2020
28
Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction. 61
32886000 2020
29
Post-infarct left ventricular thrombosis is mechanistically related to ventricular wall rupture. 61
32570160 2020
30
A successful off-pump cardiac repair following blunt cardiac rupture - A case report. 61
32875048 2020
31
Correction to: Cardiac rupture complicating acute myocardial infarction: the clinical features from an observational study and animal experiment. 61
33032539 2020
32
Cardiac rupture with conservative treatment and survival in takotsubo cardiomyopathy. 61
33082063 2020
33
Experience in treating a case of the cardiac rupture during transcatheter aortic valve implantation procedure. 61
32925283 2020
34
Lgr4 Governs a Pro-Inflammatory Program in Macrophages to Antagonize Post-Infarction Cardiac Repair. 61
32600176 2020
35
Cardiac rupture complicating acute myocardial infarction: the clinical features from an observational study and animal experiment. 61
32912149 2020
36
Subtle sings of contained cardiac rupture following myocardial infarction. 61
30733115 2020
37
Combination of eosinophil percentage and high-sensitivity C-reactive protein predicts in-hospital major adverse cardiac events in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. 61
32441412 2020
38
Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture After Myocardial Infarction. 61
32489148 2020
39
A real-world analysis of cardiac rupture on incidence, risk factors and in-hospital outcomes in 4190 ST-elevation myocardial infarction patients from 2004 to 2015. 61
32168044 2020
40
False negative of pericardial effusion using focused assessment with sonography for trauma and enhanced CT following traumatic cardiac rupture; A case report. 61
32671173 2020
41
Biomechanics of infarcted left ventricle: a review of modelling. 61
32864174 2020
42
Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin-induced cardiotoxicity. 61
32618439 2020
43
Heart rupture repair during huge mediastinal mass resection - case report. 61
32631449 2020
44
Serious takotsubo cardiomyopathy: an autopsy case presenting severe irreversible myocardial damage after frequent episodes of recurrence. 61
32693809 2020
45
Incomplete myocardial rupture following inferolateral myocardial infarction. 61
32728374 2020
46
IL-33 induces type-2-cytokine phenotype but exacerbates cardiac remodeling post-myocardial infarction with eosinophil recruitment, worsened systolic dysfunction, and ventricular wall rupture. 61
32432676 2020
47
Free Wall Myocardial Rupture and Ventricular Septal Defect in an Ambulatory Patient. 61
32642375 2020
48
Late atrioventricular groove disruption presenting 7 years after mitral valve replacement: a case report. 61
32617464 2020
49
Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than DoxilⓇ. 61
32636956 2020
50
A First Report: Two Cases of Survival and Full Recovery After Blunt Cardiac Rupture Requiring Emergency Department Thoracotomy. 61
32684024 2020

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1 11.84 PLAT MMP9 ELANE CXCL8
2 11.81 TNF PLAT MMP9
3 11.73 TNF MMP9 CXCL8
4 11.69 TNF MMP9 CXCL8
5
Show member pathways
11.69 TNF S100A9 S100A8 MMP9 CXCL8
6
Show member pathways
11.6 TNF MMP9 ELANE
7
Show member pathways
11.38 TNF MMP9 CXCL8
8 11.34 TNF MMP9 CXCL8
9 11.28 PLAT MMP9 CXCL8
10 10.61 TNF CXCL8 CRP
11 10.61 TNF PLAT MMP9 ELANE

GO Terms for Cardiac Rupture

Cellular components related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 TNF S100A9 S100A8 PLAT MMP9 ELANE
2 Z disc GO:0030018 9.43 TRIM54 FLNC FHL2
3 collagen-containing extracellular matrix GO:0062023 9.35 S100A9 S100A8 PLAT MMP9 ELANE
4 extracellular region GO:0005576 9.28 TNF S100A9 S100A8 PRF1 PLAT MMP9

Biological processes related to Cardiac Rupture according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.78 TNF S100A9 S100A8 ELANE
2 positive regulation of inflammatory response GO:0050729 9.73 TNF S100A9 S100A8
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.72 TNF S100A9 S100A8
4 regulation of inflammatory response GO:0050727 9.71 TNF S100A9 S100A8
5 neutrophil chemotaxis GO:0030593 9.67 S100A9 S100A8 CXCL8
6 inflammatory response GO:0006954 9.65 TNF S100A9 S100A8 CXCL8 CRP
7 antimicrobial humoral response GO:0019730 9.61 S100A9 S100A8 ELANE
8 embryonic digestive tract development GO:0048566 9.58 TNF CXCL8
9 astrocyte development GO:0014002 9.57 S100A9 S100A8
10 negative regulation of lipid storage GO:0010888 9.52 TNF CRP
11 chronic inflammatory response GO:0002544 9.51 S100A9 S100A8
12 autocrine signaling GO:0035425 9.46 S100A9 S100A8
13 chemokine production GO:0032602 9.4 S100A9 S100A8
14 peptidyl-cysteine S-nitrosylation GO:0018119 9.37 S100A9 S100A8
15 defense response to fungus GO:0050832 9.33 S100A9 S100A8 ELANE
16 sequestering of zinc ion GO:0032119 9.32 S100A9 S100A8
17 neutrophil aggregation GO:0070488 8.96 S100A9 S100A8
18 leukocyte migration involved in inflammatory response GO:0002523 8.8 S100A9 S100A8 ELANE

Molecular functions related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RAGE receptor binding GO:0050786 9.16 S100A9 S100A8
2 arachidonic acid binding GO:0050544 8.96 S100A9 S100A8
3 Toll-like receptor 4 binding GO:0035662 8.62 S100A9 S100A8

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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