MCID: CRD016
MIFTS: 36

Cardiac Rupture

Categories: Rare diseases

Aliases & Classifications for Cardiac Rupture

MalaCards integrated aliases for Cardiac Rupture:

Name: Cardiac Rupture 54 56
Myocardial Rupture 74

Classifications:



External Ids:

UMLS 74 C0018813

Summaries for Cardiac Rupture

MalaCards based summary : Cardiac Rupture, also known as myocardial rupture, is related to acute myocardial infarction and pericardial effusion. An important gene associated with Cardiac Rupture is PLAT (Plasminogen Activator, Tissue Type), and among its related pathways/superpathways are Transcriptional misregulation in cancer and Cell adhesion_ECM remodeling. The drugs Reteplase and Abciximab have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and liver, and related phenotypes are cardiovascular system and muscle

Wikipedia : 77 Myocardial rupture is a laceration of the ventricles or atria of the heart, of the interatrial or... more...

Related Diseases for Cardiac Rupture

Diseases related to Cardiac Rupture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 acute myocardial infarction 30.7 CHKB CRP PLAT
2 pericardial effusion 29.5 CHKB CRP
3 myocardial infarction 10.7
4 ligneous conjunctivitis 10.3 ELANE PLAT
5 capillary leak syndrome 10.3 CXCL8 ELANE
6 status asthmaticus 10.3 CXCL8 ELANE
7 farmer's lung 10.3 ELANE FLNC
8 periodontosis 10.3 CXCL8 ELANE
9 cyclic neutropenia 10.3 CXCL8 ELANE
10 myasthenic syndrome, congenital, 1a, slow-channel 10.3 CRP CXCL8
11 invasive aspergillosis 10.3 CXCL8 FLNC
12 dressler's syndrome 10.3 CRP PLAT
13 pyuria 10.3 CRP CXCL8
14 louse-borne relapsing fever 10.3 CRP CXCL8
15 pyelitis 10.2 CRP CXCL8
16 bronchopulmonary dysplasia 10.2 CXCL8 ELANE
17 acute respiratory distress syndrome 10.2 CXCL8 ELANE
18 pulmonary aspergilloma 10.2 CRP FLNC
19 viral meningitis 10.2 CRP CXCL8
20 newborn respiratory distress syndrome 10.2 CXCL8 ELANE
21 intermediate coronary syndrome 10.2 CRP PLAT
22 anterolateral myocardial infarction 10.2 CHKB PLAT
23 pharyngitis 10.2 CRP CXCL8
24 lipid pneumonia 10.2 CRP FLNC
25 septic arthritis 10.2 CRP CXCL8
26 rapidly progressive glomerulonephritis 10.2 CRP ELANE
27 alpha-1-antitrypsin deficiency 10.2 CXCL8 ELANE
28 angina pectoris 10.2 CRP PLAT
29 acute cystitis 10.2 CRP CXCL8
30 acute pyelonephritis 10.2 CRP CXCL8
31 pyelonephritis 10.2 CRP CXCL8
32 wells syndrome 10.2 CRP CXCL8
33 venous insufficiency 10.2 CRP PLAT
34 perinatal necrotizing enterocolitis 10.2 CRP CXCL8
35 peptic ulcer perforation 10.2 CRP ELANE
36 hemorrhagic fever with renal syndrome 10.2 CRP CXCL8
37 pleurisy 10.2 CRP CXCL8
38 vaginal disease 10.2 CXCL8 PRF1
39 vaginitis 10.2 CXCL8 PRF1
40 leptospirosis 10.2 CRP CXCL8
41 gingivitis 10.2 CXCL8 ELANE PLAT
42 adult respiratory distress syndrome 10.1 CXCL8 ELANE
43 preterm premature rupture of the membranes 10.1 CRP CXCL8
44 bacteriuria 10.1 CXCL8 PRF1
45 brucellosis 10.1 CRP CXCL8
46 appendicitis 10.1 CRP CXCL8
47 bronchial disease 10.1 CXCL8 ELANE FLNC
48 disseminated intravascular coagulation 10.1 ELANE PLAT
49 severe acute respiratory syndrome 10.1 CRP CXCL8
50 endocarditis 10.1 CRP CXCL8 PLAT

Graphical network of the top 20 diseases related to Cardiac Rupture:



Diseases related to Cardiac Rupture

Symptoms & Phenotypes for Cardiac Rupture

MGI Mouse Phenotypes related to Cardiac Rupture:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CRP FHL2 FLNC PLAT PMM2 PRF1
2 muscle MP:0005369 9.02 CHKB FLNC PLAT PMM2 TRIM54

Drugs & Therapeutics for Cardiac Rupture

Drugs for Cardiac Rupture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Reteplase Approved, Investigational Phase 3 133652-38-7 65820
2
Abciximab Approved Phase 3 143653-53-6
3
Exenatide Approved, Investigational Phase 3 141758-74-9 15991534
4
Glucagon Approved Phase 3 16941-32-5
5
Apixaban Approved Phase 3 503612-47-3 10182969
6
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
7 Fibrinolytic Agents Phase 3
8 Plasminogen Phase 3
9 Tissue Plasminogen Activator Phase 3
10 Anticoagulants Phase 3
11 Platelet Aggregation Inhibitors Phase 3
12 Hormones Phase 3,Not Applicable
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Hormone Antagonists Phase 3
15 Anti-Obesity Agents Phase 3
16 Incretins Phase 3
17 Glucagon-Like Peptide 1 Phase 3
18 Hypoglycemic Agents Phase 3
19 HIV Protease Inhibitors Phase 3
20
protease inhibitors Phase 3
21 Antithrombins Phase 3
22 Antithrombin III Phase 3
23 Factor Xa Inhibitors Phase 3
24 Serine Proteinase Inhibitors Phase 3
25
Lenograstim Approved, Investigational Phase 1, Phase 2 135968-09-1
26 Immunologic Factors Phase 1, Phase 2
27 Adjuvants, Immunologic Phase 1, Phase 2
28 Pharmaceutical Solutions Phase 2,Not Applicable
29
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
30 Calcium, Dietary Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Study of Abciximab and Reteplase When Administered Prior to Catherization After a Myocardial Infarction (Finesse) Completed NCT00046228 Phase 3 abciximab placebo; reteplase placebo, abciximab, abciximab;Abciximab; reteplase; abciximab placebo; abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;abciximab placebo; reteplase placebo, abciximab, abciximab;abciximab; reteplase placebo; abciximab placebo; abciximab;Abciximab; reteplase; abciximab placebo; abciximab
2 COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial Recruiting NCT02404376 Phase 3 Exenatide;Placebo
3 Phase III Acute Coronary Syndrome Terminated NCT00831441 Phase 3 Apixaban;Placebo
4 Safety and Feasibility of the Injectable BL-1040 Implant Unknown status NCT00557531 Phase 1, Phase 2
5 A Phase I - II Safety Study of Filgrastim (Neupogen) to Improve Left Ventricular Function After Severe Acute Myocardial Infarction Completed NCT00215124 Phase 1, Phase 2 Filgrastim
6 The Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Myocardial Function in Patients Undergoing LVAD Implantation Completed NCT01442129 Phase 2
7 Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD Terminated NCT00927784 Phase 2 Cryoprotective media alone
8 Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy Unknown status NCT02843464 Not Applicable
9 Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy Unknown status NCT03018873 Not Applicable
10 Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction Completed NCT02484326
11 Coronary Anatomy Study and Times Since the Onset of Acute Myocardial Infarction Symptoms in Women Until the Opening of the Artery (TAPAC Study) Completed NCT03152240
12 IK-5001 for the Prevention of Remodeling of the Ventricle and Congestive Heart Failure After Acute Myocardial Infarction Completed NCT01226563 Not Applicable
13 Efficacy of Three Dimensional Transesophageal Echocardiography for Percutaneous Device Closure in Atrial Septal Defect Recruiting NCT02097758 Not Applicable
14 Mechanical Complications of Acute Myocardial Infarction Not yet recruiting NCT03848429

Search NIH Clinical Center for Cardiac Rupture

Genetic Tests for Cardiac Rupture

Anatomical Context for Cardiac Rupture

MalaCards organs/tissues related to Cardiac Rupture:

42
Heart, Testes, Liver, Lung, Brain

Publications for Cardiac Rupture

Articles related to Cardiac Rupture:

(show top 50) (show all 450)
# Title Authors Year
1
A risk score model for predicting cardiac rupture after acute myocardial infarction. ( 30829714 )
2019
2
Subtle sings of contained cardiac rupture following myocardial infarction. ( 30733115 )
2019
3
Ischemic posterior wall cardiac rupture: early intervention is key for success. ( 30889964 )
2019
4
Ac-SDKP decreases mortality and cardiac rupture after acute myocardial infarction. ( 29364896 )
2018
5
Association of the SYNTAX Score II with cardiac rupture in patients with ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention. ( 29028739 )
2018
6
Cardiac rupture during acute myocardial infarction diagnosed clinically. ( 29394186 )
2018
7
Cardiac rupture caused by traffic accident: Case reports and a literature review. ( 29457746 )
2018
8
Cardiac Rupture in a Young Male Cocaine User. ( 29326020 )
2018
9
Delayed Cardiac Rupture Induced by Traumatic Myocardial Infarction: Consequence of a 45-Magnum Blast Injury; A Comprehensive Case Review. ( 29379803 )
2018
10
Ultrasound diagnosis of cardiac rupture caused by mechanical chest compression. ( 29922738 )
2018
11
S100A8/A9 promotes MMP-9 expression in the fibroblasts from cardiac rupture after myocardial infarction by inducing macrophages secreting TNFI+. ( 29949169 )
2018
12
IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF-κB signaling pathway in a mouse model of acute myocardial infarction. ( 30536946 )
2018
13
Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction. ( 30275441 )
2018
14
Myocardial rupture after small acute myocardial infarction in the absence of coronary artery disease. ( 30223140 )
2018
15
Trimetazidine suppresses oxidative stress, inhibits MMP-2 and MMP-9 expression, and prevents cardiac rupture in mice with myocardial infarction. ( 30019466 )
2018
16
Endogenous muscle atrophy F-box is involved in the development of cardiac rupture after myocardial infarction. ( 30408466 )
2018
17
Severe Cardiac Rupture by Only One Blow to the Chest in a Young Boy: An Autopsy Case. ( 30462838 )
2018
18
Risk factors for cardiac rupture complicating myocardial infarction: a PRISMA meta-analysis and systematic review. ( 30487185 )
2018
19
Myocardial Rupture Due to Metastasis of Urothelial Carcinoma. ( 30224587 )
2018
20
Intramyocardial contrast in a STEMI patient early direct evidence of cardiac rupture. ( 28967573 )
2017
21
Inhibition of the Renin-Angiotensin System Post Myocardial Infarction Prevents Inflammation-Associated Acute Cardiac Rupture. ( 28204966 )
2017
22
Development and validation of clinical risk score to predict the cardiac rupture in patients with STEMI. ( 28132793 )
2017
23
Can takotsubo cardiomyopathy be diagnosed by autopsy? Report of a presumed case presenting as cardiac rupture. ( 28396614 )
2017
24
Autotransplantation for Threatened Cardiac Rupture After Left Ventricular Repair. ( 28109380 )
2017
25
Extracorporeal cardiopulmonary resuscitation for blunt cardiac rupture: A case report. ( 28801040 )
2017
26
Apoptosis inhibitor of macrophage depletion decreased M1 macrophage accumulation and the incidence of cardiac rupture after myocardial infarction in mice. ( 29121663 )
2017
27
Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials. ( 28109576 )
2017
28
Long-term outcome and risk prediction in patients suffering acute myocardial infarction complicated by post-infarction cardiac rupture. ( 27847155 )
2017
29
Successful Use of Targeted Temperature Management After Repair of Myocardial Rupture from Blunt Chest Trauma: A Case Report. ( 27875660 )
2017
30
Confirmed early myocardial rupture in a patient with pulseless electrical activity (PEA) following late presentation of ST elevation myocardial infarction. ( 28420670 )
2017
31
Haploinsufficiency of Hand1 improves mice survival after acute myocardial infarction through preventing cardiac rupture. ( 27601324 )
2016
32
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture. ( 27079251 )
2016
33
Successful surgical repair of a triple cardiac rupture using modified cohesive double patch technique. ( 27385145 )
2016
34
Late Cardiac Rupture after Amplatzer Septal Occluder Implantation. ( 28100979 )
2016
35
Cardiac rupture in takotsubo cardiomyopathy treated surgically. ( 27625696 )
2016
36
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis. ( 27342873 )
2016
37
Blunt Cardiac Rupture: A Diagnostic Challenge. ( 28050441 )
2016
38
Cardiac Rupture: New Features of the Old Disease. ( 26761195 )
2016
39
Deletion of CD28 Co-stimulatory Signals Exacerbates Left Ventricular Remodeling and Increases Cardiac Rupture After Myocardial Infarction. ( 27396441 )
2016
40
Toll-like receptor 9 prevents cardiac rupture after myocardial infarction in mice independently of inflammation. ( 27769998 )
2016
41
Blunt Traumatic Cardiac Rupture: Single-Institution Experiences over 14 Years. ( 27965920 )
2016
42
Allergy to transdermal fentanyl resulting in Staphylococcus aureus sepsis and fatal endocarditis with myocardial rupture. ( 27132207 )
2016
43
Commonalities of cardiac rupture (left ventricular free wall or ventricular septum or papillary muscle) during acute myocardial infarction secondary to atherosclerotic coronary artery disease. ( 25456862 )
2015
44
Magnetic resonance imaging-based management of silent cardiac rupture. ( 25483899 )
2015
45
False negative pericardial Focused Assessment with Sonography for Trauma examination following cardiac rupture from blunt thoracic trauma: a case report. ( 26152189 )
2015
46
Echocardiography and Cardiac Rupture: Is Contrast Extravasation an Indication for Surgery? ( 26299914 )
2015
47
Use of intra-aortic balloon pump support for oozing-type cardiac rupture after acute myocardial infarction. ( 26145582 )
2015
48
Cardiac Arrest Triggered by Subepicardial Aneurysm Without Cardiac Rupture. ( 26511228 )
2015
49
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis. ( 25450231 )
2015
50
Cardiac rupture delayed for a week in an asymptomatic child following blunt trauma. ( 26311363 )
2015

Variations for Cardiac Rupture

Expression for Cardiac Rupture

Search GEO for disease gene expression data for Cardiac Rupture.

Pathways for Cardiac Rupture

Pathways related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 CXCL8 ELANE PLAT
2 11.04 CXCL8 PLAT
3 10.84 ELANE PLAT
4 9.9 CRP CXCL8

GO Terms for Cardiac Rupture

Cellular components related to Cardiac Rupture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 8.8 FHL2 FLNC TRIM54

Sources for Cardiac Rupture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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